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Information on EC 2.3.1.85 - fatty-acid synthase system and Organism(s) Homo sapiens and UniProt Accession P49327

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.85 fatty-acid synthase system
IUBMB Comments
The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase. cf. EC 2.3.1.86, fatty-acyl-CoA synthase system.
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This record set is specific for:
Homo sapiens
UNIPROT: P49327
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
+
7
+
14
+
14
=
+
8
+
7
+
14
+
6
Synonyms
fasii, fatty-acid synthase, fas-ii, type ii fatty acid synthase, yeast fatty acid synthase, fatty acid synthase ii, fatty acid synthase i, type 2 fatty acid synthase, fatty acid synthase type 2, f09e10.3 protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
fatty acid synthase
-
-
fatty-acid synthase
-
-
-
-
yeast fatty acid synthase
-
-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
-
-
-
-
redox reaction
-
-
-
-
Acyl group transfer
-
-
-
-
thioester hydrolysis
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase. cf. EC 2.3.1.86, fatty-acyl-CoA synthase system.
CAS REGISTRY NUMBER
COMMENTARY hide
9045-77-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
show the reaction diagram
-
-
-
?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
show the reaction diagram
additional information
?
-
-
fatty acid synthase-dependent palmitoylation of epidermal growth factor receptor is required for epidermal growth factor receptor dimerization and kinase activation. Inhibition of fatty acid synthase or palmitoyl acyltransferases reduces the activity and down-regulated the levels of epidermal growth factor receptor, and sensitizes cancer cells to epidermal growth factor receptor tyrosine kinase inhibitors
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
show the reaction diagram
-
multifunctional enzyme, involved in animal fat synthesis
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4'-phosphopantetheine
-
requirement, 1 mol associated with 1 mol subunit
NADPH
additional information
-
no requirement for FMN
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-[(Z)-[2-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]pyridine
good inhibition activity against two enzyme overexpressing cancer cell lines. IC50 value for MDA-MB-468 cell 0.0083 mM, for SW-480 cell 0.0015 mM
3-hydroxynaphthalen-1-yl 3,4,5-trihydroxybenzoate
analog of (-)-epigallocatechin 3-gallate. Compound displays moderate to high cytotoxicity and significantly blocks FASN activity, diminishes FASN protein expression levels and induces apoptosis
4-hydroxynaphthalen-2-yl 3,4,5-trihydroxybenzoate
analog of (-)-epigallocatechin 3-gallate. Compound displays moderate to high cytotoxicity and significantly blocks FASN activity, diminishes FASN protein expression levels and induces apoptosis
naphthalene-1,3-diyl bis(3,4,5-trihydroxybenzoate)
analog of (-)-epigallocatechin 3-gallate. Compound displays moderate to high cytotoxicity and significantly blocks FASN activity, diminishes FASN protein expression levels
[1,1'-biphenyl]-4,4'-diyl bis(3,4,5-trihydroxybenzoate)
analog of (-)-epigallocatechin 3-gallate. Compound displays moderate to high cytotoxicity and significantly blocks FASN activity
(10E,12Z)-octadec-10,12-dienoic acid
-
more potent inhibitor than (9Z,11E)-octadec-9,11-dienoic acid
(9Z,11E)-octadec-9,11-dienoic acid
-
-
1,2,3,4,6-penta-O-galloyl-beta-D-glucose
-
compound is transported across cancer cell membrane to further down-regulate FAS and activate caspase-3 in MDA-MB-231 cells. Compared with other FAS inhibitors, including catechin gallate and morin, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose involves a higher reversible fast-binding inhibition with an irreversible slow-binding inhibition, i.e. saturation kinetics with a dissociation constant of 0.59 microM and a limiting rate constant of 0.16 per min. The major reacting site of PGG is on the beta-ketoacyl reduction domain of FAS. Compound exhibits different types of inhibitions against the three substrates in the FAS overall reaction
1,3-Dibromo-2-propanone
-
-
adriamycin
-
cytotoxic activity against cancer cells, IC50 value for MCF-7 cell 0.0035 mM, for A-549 cell 0.0018 mM, for HL-60 cell 0.0008 mM
C75
-
FASN inhibitor
cerulenin
diisopropylfluorophosphate
-
-
dutasteride
-
at clinically relevant levels, inhibits FASN mRNA, protein expression and enzymatic activity in prostate cancer cells
epigallocatechin-3-gallate
-
-
ginkgolic acid C15:1
-
DELTA8 and DELTA10 isomers, at ratio 1:2. Cytotoxic activity against cancer cells, IC50 value for MCF-7 cell 0.146 mM, for A-549 cell 0.066 mM, for HL-60 cell 0.005 mM
ginkgolic acid C17:1
-
double bond positions not specified. Cytotoxic activity against cancer cells, IC50 value for MCF-7 cell 0.093 mM, for A-549 cell 0.050 mM, for HL-60 cell 0.004 mM
ginkgolic acid C17:2
-
double bond positions not specified. Cytotoxic activity against cancer cells, IC50 value for MCF-7 cell 0.108 mM, for A-549 cell 0.056 mM, for HL-60 cell 0.004 mM
iodoacetamide
-
beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects
PMSF
-
-
procyanidin
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procyanidins isolated from seeds of Hippophae rhamnoides inhibits the activity of FAS and reduces MDA-MB-231 cell viability with an IC50 value of 37.5 microg/ml. Procyanidins induce MDA-MB-231 cell apoptosis
pyridoxal 5'-phosphate
-
enoyl reductase activity, NADPH protects
tetrahydrolipstatin
-
i.e. orlistat
trans-4-carboxy-5-octyl-3-methylenebutyrolactone
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-
triclosan
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-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0005 - 0.008
acetyl-CoA
0.001 - 0.02
malonyl-CoA
0.005 - 0.4
NADPH
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.3 - 2.7
acetyl-CoA
0.3 - 2.7
malonyl-CoA
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0127
2-[(Z)-[2-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]pyridine
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0016
1,2,3,4,6-penta-O-galloyl-beta-D-glucose
Homo sapiens
-
37°C, pH not specified in the publication
additional information
procyanidin
Homo sapiens
-
IC50 value is 0.087 microg/ml, 37°C, pH not specified in the publication
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.6
-
NADPH
additional information
-
specific activities of subdomains
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.5 - 6.7
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
FAS is overexpressed significantly in pathologic and normal mucosa of patients with ulcerative colitis, mainly in the acute phase
Manually annotated by BRENDA team
-
LNCaP prostate cancer cell
Manually annotated by BRENDA team
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oral squamous carcinoma cell lines SCC-4, SCC-9, SCC-15, SCC-25, differential expression of enzyme being highest in SCC-9 followed by SCC-25
Manually annotated by BRENDA team
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at clinically relevant levels, inhibits FASN mRNA, protein expression and enzymatic activity in prostate cancer cells
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
FASN produces phospholipids for membrane microdomains that accommodate receptor tyrosine kinases including epidermal growth factor-receptor ErbB1 and ErbB2
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FAS_HUMAN
2511
0
273427
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
236000
-
SDS-PAGE
265000
-
SDS-PAGE
272000
-
SDS-PAGE
272500
-
calculated from nucleotide sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
high-resolution crystal structure of a large part of human fatty acid synthase that encompasses the tandem domain of beta-oxoacyl synthase KS connected by a linker domain to the malonyltransferase domain MAT, to 2.15 A resolution. Hinge regions that allow for substantial flexibility of the subdomains are defined. The KS domain forms the canonical dimer, and its substrate-binding site geometry differs markedly from that of bacterial homologues but is similar to that of the porcine orthologue. The didomain structure reveals a possible way to generate a small and compact KS domain by omitting a large part of the linker and MAT domains, which could greatly aid in rapid screening of KS inhibitors. In the crystal, the MAT domain exhibits two closed conformations that differ significantly by rigid-body plasticity
of thioesterase domain, which comprises two dissimilar subdomains A and B
pharmacophore modeling based on crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase domain, PDB entry 3HHD
molecular dynamic simulation based binding free energy calculation and access tunnels analysis. The C16 acyl tail fatty acid, the major product of FAS, fits to the active site on beta-ketoacyl synthase domain better than any other substrates. The geometric shape of active site on beta-ketoacyl synthase domain might explain the product ratio of FAS
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A2419L
97% reduction of thioesterase activity
A2419M
92% reduction of thioesterase activity
F2371W
20% reduction of thioesterase activity
F2423A
67% reduction of thioesterase activity
F2423W
24% reduction of thioesterase activity
I2250W
97% reduction of thioesterase activity
K2426A
99% reduction of thioesterase activity
S2422A
7% reduction of thioesterase activity
K1699A
-
specific activity is 10% of wild-type value
K1699Q
-
specific activity is 7.5% of wild-type value
S2151A
-
inactive enzyme
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
dissociation of native enzyme leads to loss of activity
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
fusion protein with maltose-binding protein
-
near homogeneity
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
full length cDNA, cDNA encoding domain I and cDNA encoding domains II and III
-
wild-type and mutant enzymes are expressed in Sf9 cells
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
(10E,12Z)-octadec-10,12-dienoic acid downregulates FAS expression in a concnetration-dependent manner, while (9Z,11E)-octadec-9,11-dienoic acid has no effect. (10E,12Z)-octadec-10,12-dienoic acid at 0.05 mM decreases FAS expression in MCF-7 cells by 52%, at 0.1 mM (10E,12Z)-octadec-10,12-dienoic acid, FAS protein is downregulated in MCF-7 (80%), LnCaP (27%), and HT-29 (61%) cells
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17beta-estradiol increases FAS expression, estrogen induces FAS expression
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C75 downregulates FASN mRNA in A2780 with an IC50 after 3d of 0.00525 mg/ml and an IT50 (time required for 50% inhibition) at 0.007 mg/ml of 21.5 h. This corresponds with FASN protein downregulation (IC50 = 0.00415 mg/ml), although the dynamics are slower (IT50 = 40 h). Pelitinib, given for 3d, abrogates FASN mRNA and protein in A-2780 cellsat doses as low as 0.003 mM
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fatty acid synthase is overexpressed in ovarian cancer
-
isoleucine, whey, leucine, valine, skim milk, and casein downregulate the expression of fatty acid synthase in a concentration-dependent manner, a plateau is reached at 1.0% (w/v) skim milk and casein corresponding to about 40% inhibition of FAS expression, whey leads to 54% inhibition of FAS expression at 2.0%(w/v)
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mithramycin inhibits FAS expression, transfection of transcription factor Sp1 siRNA suppresses FAS expression
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the stromal cell-derived factor-1 alpha/CXCR4 axis induces the expression of fatty acid synthase via sterol regulatory element binding protein-1 activation in cancer cells. Sterol regulatory element-binding protein-1 is a major modulator of fatty acid synthase transcription. Also recombinant stromal cell-derived factor-1 alpha-induced phosphatidylinositol-3'-kinase/protein kinase B (Akt) phosphorylation is involved in the expression or activities of fatty acid synthase
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transcription factor Sp3 and Sp4 siRNAs do not affect FAS expression
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
-
targeted liquid chromatography-mass spectroscopy method to directly measure endogenous levels of malonyl-CoA to drive a drug development structure-activity relationship screening cascade. The assay is amenable to multiplexing cellular endpoints, has a typical Z' of >0.6, and has high reproducibility of EC50 values
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wakil, S.J.; Stoops, J.K.; Joshi, V.C.
Fatty acid synthesis and its regulation
Annu. Rev. Biochem.
52
537-579
1983
Anser sp., Bos taurus, Canis lupus familiaris, Gallus gallus, Columba sp., Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Jayakumar, A.; Huang, W.Y.; Raetz, B.; Chirala, S.S.; Wakil, S.J.
Cloning and expression of the multifunctional human fatty acid synthase and its subdomains in Escherichia coli
Proc. Natl. Acad. Sci. USA
93
14509-14514
1996
Homo sapiens
Manually annotated by BRENDA team
Jayakumar, A.; Tai, M.H.; Huang, W.Y.; Al-Feel, W.; Hsu, M.; Abu-Elheiga, L.; Chirala, S.S.; Wakil, S.J.
Human fatty acid synthase: properties and molecular cloning
Proc. Natl. Acad. Sci. USA
92
8695-8699
1995
Homo sapiens
Manually annotated by BRENDA team
Wagle, S.; Bui, A.; Ballard, P.L.; Shuman, H.; Gonzales, J.; Gonzales, L.W.
Hormonal regulation and cellular localization of fatty acid synthase in human fetal lung
Am. J. Physiol.
277
L381-L390
1999
Homo sapiens
Manually annotated by BRENDA team
Swinnen, J.V.; Van Veldhoven, P.P.; Timmermans, L.; De Schrijver, E.; Brusselmans, K.; Vanderhoydonc, F.; Van de Sande, T.; Heemers, H.; Heyns, W.; Verhoeven, G.
Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains
Biochem. Biophys. Res. Commun.
302
898-903
2003
Homo sapiens
Manually annotated by BRENDA team
Agostini, M.; Silva, S.D.; Zecchin, K.G.; Coletta, R.D.; Jorge, J.; Loda, M.; Graner, E.
Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells
Oral Oncol.
40
728-735
2004
Homo sapiens
Manually annotated by BRENDA team
Chakravarty, B.; Gu, Z.; Chirala, S.S.; Wakil, S.J.; Quiocho, F.A.
Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain
Proc. Natl. Acad. Sci. USA
101
15567-15572
2004
Homo sapiens (P49327)
Manually annotated by BRENDA team
Carlisle-Moore, L.; Gordon, C.R.; Machutta, C.A.; Miller, W.T.; Tonge, P.J.
Substrate recognition by the human fatty-acid synthase
J. Biol. Chem.
280
42612-42618
2005
Homo sapiens
Manually annotated by BRENDA team
Asturias, F.J.
Mammalian fatty acid synthase: X-ray structure of a molecular assembly line
ACS Chem. Biol.
1
135-138
2006
Homo sapiens
Manually annotated by BRENDA team
Consolazio, A.; Alo, P.L.; Rivera, M.; Iacopini, F.; Paoluzi, O.A.; Crispino, P.; Pica, R.; Paoluzi, P.
Overexpression of fatty acid synthase in ulcerative colitis
Am. J. Clin. Pathol.
126
113-118
2006
Homo sapiens
Manually annotated by BRENDA team
Lupu, R.; Menendez, J.A.
Pharmacological inhibitors of fatty acid synthase (FASN)-catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?
Curr. Pharm. Biotechnol.
7
483-494
2006
Homo sapiens
Manually annotated by BRENDA team
van de Sande, T.; Roskams, T.; Lerut, E.; Joniau, S.; Van Poppel, H.; Verhoeven, G.; Swinnen, J.V.
High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB
J. Pathol.
206
214-219
2005
Homo sapiens
Manually annotated by BRENDA team
Wang, H.Q.; Altomare, D.A.; Skele, K.L.; Poulikakos, P.I.; Kuhajda, F.P.; Di Cristofano, A.; Testa, J.R.
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
Oncogene
24
3574-3582
2005
Homo sapiens
Manually annotated by BRENDA team
Schmidt, L.J.; Ballman, K.V.; Tindall, D.J.
Inhibition of fatty acid synthase activity in prostate cancer cells by dutasteride
Prostate
67
1111-1120
2007
Homo sapiens
Manually annotated by BRENDA team
Grunt, T.W.; Wagner, R.; Grusch, M.; Berger, W.; Singer, C.F.; Marian, B.; Zielinski, C.C.; Lupu, R.
Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells
Biochem. Biophys. Res. Commun.
385
454-459
2009
Homo sapiens
Manually annotated by BRENDA team
Kim, K.J.; Kim, H.Y.; Cho, H.K.; Kim, K.H.; Cheong, J.
The SDF-1alpha/CXCR4 axis induces the expression of fatty acid synthase via sterol regulatory element binding protein-1 activation in cancer cells
Carcinogenesis
31
679-686
2010
Homo sapiens
Manually annotated by BRENDA team
Lu, S.; Archer, M.C.
Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells
Int. J. Cancer
126
416-425
2010
Homo sapiens
Manually annotated by BRENDA team
Lau, D.S.; Archer, M.C.
The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells
Nutr. Cancer
62
116-121
2010
Homo sapiens
Manually annotated by BRENDA team
Chen, Q.; Reimer, R.A.
Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro
Nutrition
25
340-349
2009
Homo sapiens
Manually annotated by BRENDA team
Zeng, X.F.; Li, W.W.; Fan, H.J.; Wang, X.Y.; Ji, P.; Wang, Z.R.; Ma, S.; Li, L.L.; Ma, X.F.; Yang, S.Y.
Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain
Bioorg. Med. Chem. Lett.
21
4742-4744
2011
Homo sapiens (P49327)
Manually annotated by BRENDA team
Oh, J.; Hwang, I.H.; Hong, C.E.; Lyu, S.Y.; Na, M.
Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity
J. Enzyme Inhib. Med. Chem.
28
565-568
2013
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Pappenberger, G.; Benz, J.; Gsell, B.; Hennig, M.; Ruf, A.; Stihle, M.; Thoma, R.; Rudolph, M.G.
Structure of the human fatty acid synthase KS-MAT didomain as a framework for inhibitor design
J. Mol. Biol.
397
508-519
2010
Homo sapiens (P49327)
Manually annotated by BRENDA team
Zhao, W.; Wang, Y.; Hao, W.; Zhao, M.; Peng, S.
In vitro inhibition of fatty acid synthase by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose plays a vital role in anti-tumour activity
Biochem. Biophys. Res. Commun.
445
346-351
2014
Homo sapiens
Manually annotated by BRENDA team
Cui, W.; Liang, Y.; Tian, W.; Ji, M.; Ma, X.
Regulating effect of beta-ketoacyl synthase domain of fatty acid synthase on fatty acyl chain length in de novo fatty acid synthesis
Biochim. Biophys. Acta
1861
149-155
2016
Homo sapiens
Manually annotated by BRENDA team
Hopperton, K.E.; Duncan, R.E.; Bazinet, R.P.; Archer, M.C.
Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity
Exp. Cell Res.
320
302-310
2014
Homo sapiens
Manually annotated by BRENDA team
Hopcroft, P.; Fisher, D.
Development of a medium-throughput targeted LCMS assay to detect endogenous cellular levels of malonyl-CoA to screen fatty acid synthase inhibitors
J. Biomol. Screen.
21
111-116
2016
Homo sapiens
Manually annotated by BRENDA team
Liu, H.; Wu, X.; Dong, Z.; Luo, Z.; Zhao, Z.; Xu, Y.; Zhang, J.T.
Fatty acid synthase causes drug resistance by inhibiting TNF-alpha and ceramide production
J. Lipid Res.
54
776-785
2013
Homo sapiens
Manually annotated by BRENDA team
Bollu, L.R.; Katreddy, R.R.; Blessing, A.M.; Pham, N.; Zheng, B.; Wu, X.; Weihua, Z.
Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation
Oncotarget
6
34992-35003
2015
Homo sapiens
Manually annotated by BRENDA team
Wang, Y.; Nie, F.; Ouyang, J.; Wang, X.; Ma, X.
Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells
Tumour Biol.
35
9563-9569
2014
Homo sapiens
Manually annotated by BRENDA team
Crous-Maso, J.; Palomeras, S.; Relat, J.; Camo, C.; Martinez-Garza, U.; Planas, M.; Feliu, L.; Puig, T.
(-)-Epigallocatechin 3-gallate synthetic analogues inhibit fatty acid synthase and show anticancer activity in triple negative breast cancer
Molecules
23
1160
2018
Homo sapiens (P49327)
Manually annotated by BRENDA team