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The expected taxonomic range for this enzyme is: Rattus norvegicus
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3-sn-phosphatidylcholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol
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Acyl group transfer
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3-sn-phosphatidylcholine:dolichol O-acyltransferase
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3-sn-phosphatidylcholine + dolichol
1-acyl-sn-glycero-3-phosphocholine + acyldolichol
3-sn-phosphatidylcholine + dolichol
1-acyl-sn-glycero-3-phosphocholine + acyldolichol
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dolichols with 16-22 isopren units, no substrates are phosphatidylethanolamine, lysophosphatidylcholine, sphingomyelin and palmitoyl-CoA
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3-sn-phosphatidylcholine + dolichol
1-acyl-sn-glycero-3-phosphocholine + acyldolichol
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dolichols with 16-22 isopren units, no substrates are phosphatidylethanolamine, lysophosphatidylcholine, sphingomyelin and palmitoyl-CoA
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additional information
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no requirement for CoA, ATP and Mg2+, separately or together
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additional information
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no Mg2+ required
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Triton X-100
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high concentration, stimulation at low concentration
additional information
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not inhibited by retinol
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Triton X-100
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1%, several fold activation, inhibition at 3%
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4.8 - 7.5
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approx. half-maximal activity at pH 4.8 and 7.5
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female, Sprague-Dawley strain
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female, Sprague-Dawley strain
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predominant
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predominant
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predominant, subcellular distribution
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predominant, subcellular distribution
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and below, inactivation
487554
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additional information
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inactivation at room temperature and above
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Keenan, R.W.; Kruczek, M.E.
The esterification of dolichol by rat liver microsomes
Biochemistry
15
1586-1591
1976
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
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