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EC Tree
IUBMB Comments The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
The taxonomic range for the selected organisms is: Glycine max The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
chalcone synthase, ascl1, ascl2, chs-1, chs_h1, gmirchs, flavanone synthase, ripks4, chs-7, 6'-deoxychalcone synthase,
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naringenin-chalcone synthase 6
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6'-deoxychalcone synthase
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chalcone synthase
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chalcone synthetase
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flavanone synthase
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flavanone synthetase
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naringenin-chalcone synthase
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synthase, flavanone
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Acyl group transfer
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malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
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4-coumaroyl-CoA + 3 malonyl-CoA
naringenin chalcone + 4 CoA + 3 CO2
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?
3 malonyl-CoA + 4-coumaroyl-CoA
4 CoA + naringenin chalcone + 3 CO2
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caffeoyl-CoA + 3 malonyl-CoA
eriodictyol + 4 CoA + 3 CO2
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cinnamoyl-CoA + malonyl-CoA
5,7-dihydroxyflavanone + CoA + CO2
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15% of the reaction rate with 4-coumaroyl-CoA
i.e. pinocembrin
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ferulyl-CoA + malonyl-CoA
homoeriodictyol + CoA + CO2
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reaction gives one major and 3 minor reaction products, none of those is identical with homoeriodictyol
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malonyl CoA + 4-coumaroyl-CoA + NADH
6'-deoxychalcone + CoA + CO2 + NAD+
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the formation of this product requires an additional reductase
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malonyl-CoA + 4-coumaroyl-CoA
naringenin chalcone + CoA + CO2
malonyl-CoA + 4-coumaroyl-CoA + NADPH
5'-deoxyflavanone + CoA + CO2 + NADP+
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the formation of this product requires an additional reductase
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additional information
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malonyl-CoA + 4-coumaroyl-CoA
naringenin chalcone + CoA + CO2
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malonyl-CoA + 4-coumaroyl-CoA
naringenin chalcone + CoA + CO2
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malonyl-CoA + 4-coumaroyl-CoA
naringenin chalcone + CoA + CO2
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additional information
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GmIRCHS is the I gene that inhibits pigmentation over the entire seed coat, resulting in a uniform yellow color of mature harvested seeds
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additional information
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GmIRCHS is the I gene that inhibits pigmentation over the entire seed coat, resulting in a uniform yellow color of mature harvested seeds
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3 malonyl-CoA + 4-coumaroyl-CoA
4 CoA + naringenin chalcone + 3 CO2
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additional information
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additional information
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GmIRCHS is the I gene that inhibits pigmentation over the entire seed coat, resulting in a uniform yellow color of mature harvested seeds
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additional information
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GmIRCHS is the I gene that inhibits pigmentation over the entire seed coat, resulting in a uniform yellow color of mature harvested seeds
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additional information
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type IV chalcone isomerase-like protein (CHIL) binds to the enzyme to serve as a rectifier - rather than an activator - of promiscuous enzyme; it enhances enzyme-catalyzed THC production and diminishes CTAL formation without enhancing total polyketide production, thereby facilitating the efficient influx of substrates from the general phenylpropanoid pathway to the flavonoid pathway
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SwissProt
brenda
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hairy roots, transformed with the soybean chalcone synthase (CHS6) or isoflavone synthase (IFS2) genes, with dramatically decreased capacity to synthesize isoflavones are produced to determine what effects these changes would have on susceptibility to a fungal pathogen. Blockage of isoflavone synthesis by constitutive expression of two key genes in the isoflavonoid pathway, chalcone synthase and isoflavone synthase leads to the inability to synthesize glyceollin in soybean hairy roots on root resistance to Fusarium solani f. sp. glycines
brenda
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brenda
expression patterns is higher at 70 d after pollination in both the cultivars. Expression of the gene coincides with the onset of accumulation of isoflavonoids in the embryos. CHS7 is expressed at significantly greater level in RCAT Angora than in Harovinton
brenda
expression patterns is higher at 70 d after pollination in both the cultivars. Expression of the gene coincides with the onset of accumulation of isoflavonoids in the embryos. CHS8 is expressed at significantly greater level in RCAT Angora than in Harovinton
brenda
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CHS6_SOYBN
388
0
42532
Swiss-Prot
other Location (Reliability: 3 )
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40000
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2 * 40000, SDS-PAGE
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dimer
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2 * 40000, SDS-PAGE
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hairy roots, transformed with the soybean chalcone synthase (CHS6) or isoflavone synthase (IFS2) genes, with dramatically decreased capacity to synthesize isoflavones are produced to determine what effects these changes would have on susceptibility to a fungal pathogen
expressed in Escherichia coli BL21 cells
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Welle, R.; Grisebach, H.
Isolation of a novel NADPH-dependent reductase which coacts with chalcone synthase in the biosynthesis of 6'-deoxychalcone
FEBS Lett.
236
221-225
1988
Glycine max
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brenda
Schrder, J.; Schrder, G.
Stilbene and chalcone synthases: Related enzymes with key functions in plant-specific pathways
Z. Naturforsch. C
45c
1-8
1990
Arabidopsis thaliana, Glycine max, Sinapis alba
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brenda
Welle, R.; Grisebach, H.
Purification and properties of chalcone synthase from cell suspension cultures of soybean
Z. Naturforsch. C
42c
1200-1206
1987
Glycine max
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brenda
Dhaubhadel, S.; Gijzen, M.; Moy, P.; Farhangkhoee, M.
Transcriptome analysis reveals a critical role of CHS7 and CHS8 genes for isoflavonoid synthesis in soybean seeds
Plant Physiol.
143
326-338
2007
Glycine max (P30081), Glycine max (Q84V87), Glycine max
brenda
Lozovaya, V.V.; Lygin, A.V.; Zernova, O.V.; Ulanov, A.V.; Li, S.; Hartman, G.L.; Widholm, J.M.
Modification of phenolic metabolism in soybean hairy roots through down regulation of chalcone synthase or isoflavone synthase
Planta
225
665-679
2007
Glycine max (P30080), Glycine max
brenda
Kasai, A.; Kasai, K.; Yumoto, S.; Senda, M.
Structural features of GmIRCHS, candidate of the I gene inhibiting seed coat pigmentation in soybean: implications for inducing endogenous RNA silencing of chalcone synthase genes
Plant Mol. Biol.
64
467-479
2007
Glycine max (Q6X0M8), Glycine max
brenda
Waki, T.; Mameda, R.; Nakano, T.; Yamada, S.; Terashita, M.; Ito, K.; Tenma, N.; Li, Y.; Fujino, N.; Uno, K.; Yamashita, S.; Aoki, Y.; Denessiouk, K.; Kawai, Y.; Sugawara, S.; Saito, K.; Yonekura-Sakakibara, K.; Morita, Y.; Hoshino, A.; Takahashi, S.; Nakayama, T.
A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity
Nat. Commun.
11
870
2020
Antirrhinum majus, Glycine max
brenda