Information on EC 2.3.1.62 - 2-acylglycerophosphocholine O-acyltransferase

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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
2.3.1.62
-
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RECOMMENDED NAME
GeneOntology No.
2-acylglycerophosphocholine O-acyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine = CoA + phosphatidylcholine
show the reaction diagram
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Glycerophospholipid metabolism
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-
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
64295-73-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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-
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Manually annotated by BRENDA team
male Wistar strain
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
NT-1
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-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
show the reaction diagram
arachidonoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-arachidonoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
arachidonoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-arachidonoyl-2-palmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
gamma-linolenoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-gamma-linolenoyl-2-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
linoleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-linoleoyl-2-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
linoleoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-linoleoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
linoleoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-linoleoyl-2-palmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
myristoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-myristoyl-2-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
oleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
oleoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
oleoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
palmitoleoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoleoyl-2-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
palmitoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
show the reaction diagram
palmitoyl-CoA + 2-linolenoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-linolenoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 2-linoleoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 2-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
show the reaction diagram
palmitoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
palmitoyl-CoA + 2-stearoyl-sn-glycero-3-phosphocholine
CoA + 1-palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine
show the reaction diagram
stearoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-acyl-sn-glycero-3-phosphocholine
show the reaction diagram
stearoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
show the reaction diagram
stearoyl-CoA + 2-linolenoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-linolenoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
stearoyl-CoA + 2-linoleoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
stearoyl-CoA + 2-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
stearoyl-CoA + 2-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1-stearoyl-2-palmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
stearoyl-CoA + 2-stearoyl-sn-glycero-3-phosphocholine
CoA + 1,2-distearoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine
CoA + phosphatidylcholine
show the reaction diagram
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
enhanced activity by 75%
additional information
-
Ca2+ does not affect activity
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,5'-dithiobis-(2-nitrobenzoic acid)
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0.5 mM 76% activity
dithiothreitol
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0.5 mM 47% activity
N-ethylmaleimide
p-chloromercuribenzoate
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above 2.0 mM
palmitoyl-CoA
stearoyl-CoA
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above 0.064 mM
additional information
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
bovine serum albumin
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fatty acid deficient, 2 mg per ml
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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specific activities of microsomal preparations from cells grown at different temperatures
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-70°C, membrane preparation, at least 2 months
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LINKS TO OTHER DATABASES (specific for EC-Number 2.3.1.62)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)