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Information on EC 2.3.1.6 - choline O-acetyltransferase and Organism(s) Danio rerio and UniProt Accession B2ZGJ1

for references in articles please use BRENDA:EC2.3.1.6
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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.6 choline O-acetyltransferase
IUBMB Comments
Propanoyl-CoA can act, more slowly, in place of acetyl-CoA.
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This record set is specific for:
Danio rerio
UNIPROT: B2ZGJ1
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Word Map
The taxonomic range for the selected organisms is: Danio rerio
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
choline acetyltransferase, choline acetyl transferase, pchat, choline-acetyltransferase, cchat, choline acetylase, choline o-acetyltransferase, acetyl-coa:choline o-acetyltransferase, peripheral type of choline acetyltransferase, acetyl-coa:choline-o-acetyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
choline acetyltransferase
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acetyl CoA:choline-O-acetyltransferase
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acetyl-CoA:choline-O-acetyltransferase
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acetyltransferase, choline
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chAcT
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choline acetyl transferase
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choline acetylase
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choline acetyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:choline O-acetyltransferase
Propanoyl-CoA can act, more slowly, in place of acetyl-CoA.
CAS REGISTRY NUMBER
COMMENTARY hide
9012-78-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CLAT_DANRE
637
0
71840
Swiss-Prot
other Location (Reliability: 2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
S102R
mutation in the catalytic domain and in the vicinity of the active site of the enzyme. The change affects protein structure and has a direct impact on the catalytic domain of the protein which abolishes embryo motility almost completely. Mutant fish display reduced embryonic motility from 24 hours post-fertilization onwards. The heart beats at normal rate at 48 hours post-fertilization but decreases over time and ceases around 5 days post-fertilization, resulting in death. The swim bladder fails to inflate. Heterozygotes do not exhibit any mobility or other obvious defects and become healthy adults
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wang, M.; Wen, H.; Brehm, P.
Function of neuromuscular synapses in the zebrafish choline-acetyltransferase mutant bajan
J. Neurophysiol.
100
1995-2004
2008
Danio rerio (B2ZGJ1), Danio rerio
Manually annotated by BRENDA team
Joshi, S.; Virdi, S.; Etard, C.; Geisler, R.; Straehle, U.
Mutation of a serine near the catalytic site of the choline acetyltransferase a gene almost completely abolishes motility of the zebrafish embryo
PLoS ONE
13
e0207747
2018
Danio rerio (B2ZGJ1), Danio rerio
Manually annotated by BRENDA team