Information on EC 2.3.1.52 - 2-acylglycerol-3-phosphate O-acyltransferase

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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
2.3.1.52
-
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RECOMMENDED NAME
GeneOntology No.
2-acylglycerol-3-phosphate O-acyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + 2-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
-
-
Glycerophospholipid metabolism
-
-
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase
Saturated acyl-CoA thioesters are the most effective acyl donors.
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CAS REGISTRY NUMBER
COMMENTARY hide
51901-17-8
-
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
C57BL strain
-
-
Manually annotated by BRENDA team
C57BL strain
-
-
Manually annotated by BRENDA team
pea, cv. Kleine Rheinlaenderin
-
-
Manually annotated by BRENDA team
spinach, cv. Subito
-
-
Manually annotated by BRENDA team
WH-14
-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
-
initial step in glycerophospholipid synthesis
-
-
?
arachidonoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-arachidonoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
poor acyl donor
-
-
?
lauroyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-lauroyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
poor acyl donor
-
-
?
linoleoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-linoleoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
poor acyl donor
-
-
?
myristoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-myristoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
poor acyl donor
-
-
?
oleoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
palmitoleoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-palmitoleoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
poor acyl donor
-
-
?
palmitoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-palmitoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
stearoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-stearoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
most effective acyl donor
-
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
-
initial step in glycerophospholipid synthesis
-
-
?
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.073
-
partially purified
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
etiolated
Manually annotated by BRENDA team
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
top print hide
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-70°C, membrane preparation, at least 2 months
-
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial, solubilized with Triton X-100
-
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LINKS TO OTHER DATABASES (specific for EC-Number 2.3.1.52)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)