Information on EC 2.3.1.52 - 2-acylglycerol-3-phosphate O-acyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
2.3.1.52
-
RECOMMENDED NAME
GeneOntology No.
2-acylglycerol-3-phosphate O-acyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
acyl-CoA + 2-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Acyl group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Glycerophospholipid metabolism
-
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase
Saturated acyl-CoA thioesters are the most effective acyl donors.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
2-acylglycerophosphate acyltransferase
-
-
-
-
acyl-CoA:2-monoacyl-sn-glycerol 3-phosphate acyltransferase
-
-
-
-
acyltransferase, 2-acylglycerol phosphate
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
51901-17-8
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
C57BL strain
-
-
Manually annotated by BRENDA team
Mus musculus C57BL
C57BL strain
-
-
Manually annotated by BRENDA team
pea, cv. Kleine Rheinlaenderin
-
-
Manually annotated by BRENDA team
Wistar strain, pregnant female
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae OC-2
OC-2
-
-
Manually annotated by BRENDA team
spinach, cv. Subito
-
-
Manually annotated by BRENDA team
Tetrahymena pyriformis WH-14
WH-14
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
-
initial step in glycerophospholipid synthesis
-
-
?
arachidonoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-arachidonoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
poor acyl donor
-
-
?
lauroyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-lauroyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
poor acyl donor
-
-
?
linoleoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-linoleoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
poor acyl donor
-
-
?
myristoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-myristoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
poor acyl donor
-
-
?
oleoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
-
?
oleoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
-
?
oleoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
-
?
oleoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
preferred substrate
-
-
?
oleoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
poor
-
-
?
oleoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
poor
-
-
?
oleoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
Mus musculus C57BL
-
preferred substrate
-
-
?
palmitoleoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-palmitoleoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
poor acyl donor
-
-
?
palmitoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-palmitoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-palmitoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-palmitoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-palmitoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-palmitoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
preferred substrate
-
-
?
palmitoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-palmitoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
predominant selectivity for saturated acyl-CoA thioesters
-
-
?
palmitoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-palmitoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
Mus musculus C57BL
-
-
-
-
?
stearoyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1-stearoyl-2-acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
most effective acyl donor
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 2-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
-
initial step in glycerophospholipid synthesis
-
-
?
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
0.073
-
-
partially purified
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
25
-
-
assay at
37
-
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Mus musculus C57BL, Tetrahymena pyriformis WH-14
-
-
-
-
Manually annotated by BRENDA team
Tetrahymena pyriformis WH-14
-
to a lesser extent
-
Manually annotated by BRENDA team
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
-70°C, membrane preparation, at least 2 months
-
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
partial, solubilized with Triton X-100
-