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Information on EC 2.3.1.51 - 1-acylglycerol-3-phosphate O-acyltransferase and Organism(s) Homo sapiens and UniProt Accession Q99943

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EC Tree
IUBMB Comments
Acyl-[acyl-carrier protein] can also act as an acyl donor. The animal enzyme is specific for the transfer of unsaturated fatty acyl groups.
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This record set is specific for:
Homo sapiens
UNIPROT: Q99943
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
abhd5, agpat2, lpaat, lysophosphatidic acid acyltransferase, lpaat-beta, agpat1, 1-acylglycerol-3-phosphate o-acyltransferase, agpat3, lpa acyltransferase, agpat4, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-acyl-sn-glycero-3-phosphate acyltransferase 1
-
1-acyl-sn-glycerol-3-phosphate acyltransferase
-
lysophosphatidic acid acyltransferase
-
1-acyl-sn-glycero-3-phosphate acyltransferase
-
-
-
-
1-acyl-sn-glycero-3-phosphate acyltransferase 9
-
1-acyl-sn-glycerol 3-phosphate acyltransferase
-
-
-
-
1-acyl-sn-glycerol-3-phosphate acyltransferase
1-acylglycero-3-phosphate acyltransferase
-
-
-
-
1-acylglycerol-3-phosphate acyltransferase
-
-
1-acylglycerol-3-phosphate-O-acyltransferase
1-acylglycerol-3-phosphate-O-acyltransferase 2
-
-
1-acylglycerol-3-phosphate-O-acyltransferase isoform10/glycerol-3-phosphate acyltransferase isoform 3
-
-
1-acylglycerolphosphate acyltransferase
1-acylglycerophosphate acyltransferase
-
-
-
-
acyltransferase, 1-acylglycerol phosphate
-
-
-
-
AGPAT
AGPAT10/GPAT3
-
-
AGPAT2
AGPAT3
AGPAT6/GPAT4
-
-
cgi-58 protein
-
-
CGI-58/ABHD5
-
-
coenzyme A-dependent lysophosphatidic acid
-
-
LPAAT
LPAAT-beta
-
-
LPAAT3
-
-
LPAATbeta
-
lysophosphatidic acid acyltransferase
lysophosphatidic acid acyltransferase 3
-
-
lysophosphatidic acid acyltransferase beta
-
-
lysophosphatidic acid ayltransferase
-
-
lysophosphatidic acid-acyltransferase
-
-
-
-
lysophosphatidic acid–specific acyltransferase
-
-
additional information
-
the enzyme belongs to the alpha/beta-hydrolase family
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
Acyl-[acyl-carrier protein] can also act as an acyl donor. The animal enzyme is specific for the transfer of unsaturated fatty acyl groups.
CAS REGISTRY NUMBER
COMMENTARY hide
51901-16-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1,2-diacyl-lysophosphatidic acid
show the reaction diagram
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
acyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 2-acyl-1-oleoyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
?
alpha-linolenoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-alpha-linolenoyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
?
arachidoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-arachidoyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
?
lauroyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-lauroyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
?
lignoceroyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-lignoceroyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
?
linolenoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-linolenoyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
?
linoleoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-linoleoyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
linoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-linoleoyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
?
linoleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-linoleoyl-sn-glycerol 3-phosphate
show the reaction diagram
linoleoyl-CoA is second best acyl-CoA substrate
-
-
?
myristoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-myristoyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
myristoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-myristoyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
?
oleoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-oleoyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
oleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-oleoyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
?
oleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1,2-dioleoyl-sn-glycerol 3-phosphate
show the reaction diagram
both substrates are preferred
-
-
?
palmitoleoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-palmitoleoyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
palmitoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-palmitoleoyl-sn-glycerol 3-phosphate
show the reaction diagram
palmitoleoyl-CoA is a good substrate
-
?
palmitoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-palmitoyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
show the reaction diagram
pentadecanoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-pentadecanoyl-sn-glycerol 3-phosphate
show the reaction diagram
rate is similar to oleoyl-CoA and linoleoyl-CoA
-
-
?
stearoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-stearoyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
stearoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-stearoyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
?
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1,2-diacyl-lysophosphatidic acid
show the reaction diagram
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
arachidonoyl-CoA + 1-oleoyl-glycerol-3-phosphate
1-oleoyl-2-arachidonoyl-glycerol-3-phosphate + CoA
show the reaction diagram
-
-
-
-
?
arachidonoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-arachidonoyl-sn-glycerol 3-phosphate
show the reaction diagram
about half of the rate with oleoyl-CoA
-
-
?
heptadecanoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-heptadecanoyl-sn-glycerol 3-phosphate
show the reaction diagram
linoleoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-linoleoyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
linoleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-linoleoyl-sn-glycerol 3-phosphate
show the reaction diagram
myristoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-myristoyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
myristoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-myristoyl-sn-glycerol 3-phosphate
show the reaction diagram
-
about 25% of the activity with oleoyl-CoA by AGPAT10/GPAT3
-
-
?
oleoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-oleoyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
oleoyl-CoA + 1-oleoyl-2-lysophosphatidylcholine
CoA + 1,2-dioleoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
about 10% of the activity with 1-oleoyl-2-lysophopshatidic acid by AGPAT10/GPAT3
-
-
?
oleoyl-CoA + 1-oleoyl-2-lysophosphatidylethanolamine
CoA + 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
show the reaction diagram
-
about 10% of the activity with 1-oleoyl-2-lysophopshatidic acid by AGPAT10/GPAT3
-
-
?
oleoyl-CoA + 1-oleoyl-2-lysophosphatidylglycerol
CoA + 1,2-dioleoyl-sn-glycero-3-phosphate
show the reaction diagram
-
about 10% of the activity with 1-oleoyl-2-lysophopshatidic acid by AGPAT10/GPAT3
-
-
?
oleoyl-CoA + 1-oleoyl-2-lysophosphatidylinositol
CoA + 1,2-dioleoyl-sn-phosphatidylinositol
show the reaction diagram
oleoyl-CoA + 1-oleoyl-2-lysophosphatidylserine
CoA + 1,2-dioleoyl-sn-glycerol-3-phospho-L-serine
show the reaction diagram
-
about 10% of the activity with 1-oleoyl-2-lysophopshatidic acid by AGPAT10/GPAT3
-
-
?
oleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1,2-dioleoyl-sn-glycerol 3-phosphate
show the reaction diagram
oleoyl-CoA + 1-oleoyl-sn-glycerol-3-phosphate
CoA + 1,2-dioleoyl-sn-glycerol 3-phosphate
show the reaction diagram
palmitoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-palmitoyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-palmitoyl-sn-glycerol 3-phosphate
show the reaction diagram
pentadecanoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-pentadecanoyl-sn-glycerol 3-phosphate
show the reaction diagram
50% of the rate with oleoyl-CoA and linoleoyl-CoA
-
-
?
stearoyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1-acyl-2-stearoyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
stearoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
CoA + 1-oleoyl-2-stearoyl-sn-glycerol 3-phosphate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1,2-diacyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidic acid
CoA + 1,2-diacyl-lysophosphatidic acid
show the reaction diagram
-
-
-
?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
oleoyl-CoA + 1-oleoyl-2-lysophosphatidylinositol
CoA + 1,2-dioleoyl-sn-phosphatidylinositol
show the reaction diagram
-
-
-
-
?
additional information
?
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
CI-976
-
inhibits LPAAT and stimulates Golgi tubules
lysophosphatidylcholine
-
inhibits 68% of the enzyme activity at 30 microM
Phospholipids
-
activity inhibited by high concentrations of
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0053 - 0.0342
1-acyl-sn-glycerol 3-phosphate
0.0036 - 0.0083
palmitoyl-CoA
0.0048 - 0.0092
1-oleoyl-sn-glycerol 3-phosphate
0.0027 - 0.0215
oleoyl-CoA
0.012
palmitoyl-CoA
-
stearoyl-CoA as an acyl donor reveals only 33% of the activity observed under the standard assay conditions
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
22
oleoyl-CoA
-
pH 7.4, 37°C, recombinant AGPAT10/GPAT3
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
assay at
7.4
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
activity assay at
30
-
activity assay at
37
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
cDNA library
Manually annotated by BRENDA team
expression of AGPAT7
Manually annotated by BRENDA team
-
mature
Manually annotated by BRENDA team
expression of AGPAT7
Manually annotated by BRENDA team
expression of AGPAT7
Manually annotated by BRENDA team
expression of AGPAT7
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
white adipose tissue of mice, precise role of cgi-58 protein in the cytoplasm unknown
Manually annotated by BRENDA team
-
integral enzyme
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
the successive acylation of glycerol-3-phosphate (G3P) by glycerol-3-phosphate acyltransferases and acylglycerol-3-phosphate acyltransferases produces phosphatidic acid (PA), a precursor for CDP-diacylglycerol-dependent phospholipid synthesis. PA is further dephosphorylated by LIPINs to produce diacylglycerol (DG), a substrate for the synthesis of triglyceride (TG) by DG acyltransferases and a precursor for phospholipid synthesis via the CDP-choline and CDP-ethanolamine (Kennedy) pathways. The channeling of fatty acids into TG for storage in lipid droplets and secretion in lipoproteins or phospholipids for membrane biogenesis is dependent on isoform expression, activity and localization of G3P pathway enzymes, as well as dietary and hormonal and tissue-specific factors. Mechanisms that control partitioning of substrates into lipid products of the G3P pathway, glycerol-3-phosphate biosynthetic pathway, overview. Substrate channeling in the glycerol-3-phosphate pathway regulates the synthesis, storage and secretion of glycerolipids
physiological function
while isozymes AGPAT1 and 2 show strict acyl acceptor specificity for lysophosphatidic acid, other isoforms utilize lyso-PC, -PE and -phosphatidylserine (PS) as acyl acceptors. Isozymes AGPAT3, AGPAT4, and AGPAT5 have LPAAT activity with oleoyl-CoA as the acyl donor, but also have LPLAT activity with a preference for polyunsaturated acyl-CoAs, suggesting a dual role in glycerolipid synthesis and remodeling
malfunction
metabolism
the successive acylation of glycerol-3-phosphate (G3P) by glycerol-3-phosphate acyltransferases and acylglycerol-3-phosphate acyltransferases produces phosphatidic acid (PA), a precursor for CDP-diacylglycerol-dependent phospholipid synthesis. PA is further dephosphorylated by LIPINs to produce diacylglycerol (DG), a substrate for the synthesis of triglyceride (TG) by DG acyltransferases and a precursor for phospholipid synthesis via the CDP-choline and CDP-ethanolamine (Kennedy) pathways. The channeling of fatty acids into TG for storage in lipid droplets and secretion in lipoproteins or phospholipids for membrane biogenesis is dependent on isoform expression, activity and localization of G3P pathway enzymes, as well as dietary and hormonal and tissue-specific factors. Mechanisms that control partitioning of substrates into lipid products of the G3P pathway, glycerol-3-phosphate biosynthetic pathway, overview. Substrate channeling in the glycerol-3-phosphate pathway regulates the synthesis, storage and secretion of glycerolipids
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PLCA_HUMAN
283
3
31717
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
43380
x * 43380, claculated
additional information
-
45 kDa protein in Western Blot and mass spectrometry analysis, subcellular fractions of white adipose tissue
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 43380, claculated
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
I208A
mutant of human AGPAT1
P207L
mutant of human AGPAT1
R149K
mutant of human AGPAT1
T180S
mutant of human AGPAT1
140delF
-
34.8% of wild-type activity
221delGT
-
5% of wild-type activity
252delMRT
-
3.2% of wild-type activity
A239V
-
90% of wild-type activity
D168R
-
site-directed mutagenesis, the mutant shows slightly increased activity compared to the wild-type AGPAT8
D180fsX251
-
7.7% of wild-type activity
E260K
-
site-directed mutagenesis, mutation found in Chanarin-Dorfman syndrome patients, mutation without significant effect on acyltransferase activity
G136R
-
40.3% of wild-type activity
L228P
-
23.7% of wild-type activity
Q130P
-
site-directed mutagenesis, mutation found in Chanarin-Dorfman syndrome patients, mutation without significant effect on acyltransferase activity
R68X
-
14.2% of wild-type activity
V167fsX228
-
14.9% of wild-type activity
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
gel filtration, wild-type and mutant protein
gel filtration and SDS-PAGE, recombinant protein, mutant and wild-type
-
recombinant enzyme partially from CHO-K1 cell microsomes
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Baculovirus-Sf9 insect cells, pESC-URA yeast expression vector with a c-myc-epitope, transformation into Escherichia coli after site-directed mutagenesis
expression in insect and mammalian cell lines. The enzyme gene is located in the MHC class III region
expression via recombinant adenoviruses in Agpat2 -/- mice
AGPAT10/GPAT3, expression in CHO cells endoplasmic reticulum, and as AGPAT-active enzyme in HEK-293 cells via transfection with an adenoviral vector, overexpression of the AGPAT-active enzyme in Huh-7 cells depleted of endogenous AGPAT activity by shRNA-AGPAT2-lentivirus
-
expressed in Escherichia coli, plasmids pCR2.1, pDrive, pcDNA 3.1(C)neo, construction of the wild-type fusion protein with GFP, overexpression in CHO-cells, coexpression in CHO-cells with AGPAT1
expression in Chineses hamster ovary cells
-
expression in CHO cell, HeLa cell and HEK-293 cell
expression in HEK-293 cell
expression in osteosarcoma cell
expression via recombinant adenoviruses in Agpat2 -/- mice
gene AGPAT2, expression of C-terminally HA-tagged AGPAT2 in CHO-K1 cells
gene AGPAT7, DNA and amino acid sequence determination and analysis, chromosomal mapping to 15q14, expression analysis
gene AGPAT8, DNA and amino acid sequence determination and analysis, localization on chromosome 2p23.1, genetic structure, expression analysis, stable expression of wild-type and mutant enzymes in CHO cells
-
overexpressed in Escherichia coli BL21 (DE3), pCMV-SPORT6 vector, overexpressed in Saccharomyces cerevisiae, pYES2 vector
-
stable functional expression of GFP-tagged LPAAT3 in HeLa cells and in Rattus norvegicus hepatocytes with localization in the Golgi membranes
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
AGPAT2 expression is increased during adipocyte differentiation and mutations cause congenital generalised lipodystrophy (CGL) type 1
expression of isoform AGPAT11 mRNA is significantly upregulated in human breast, cervical, and colorectal cancer tissues
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
the role of isoforms AGPAT1 or AGPAT2 in liver lipogenesis is minimal and accumulation of liver fat is primarily a consequence of insulin resistance and loss of adipose tissue in Agpat2 -/- mice
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mizuno, M.; Sugiura, Y.; Okuyama, H.
Properties of acyl-coenzyme A:1-acylglycerophosphate acyltransferase and lipases in porcine erythrocyte membranes
J. Lipid Res.
25
843-850
1984
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Aguado, B.; Campbell, R.D.
Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex
J. Biol. Chem.
273
4096-4105
1998
Homo sapiens (Q99943), Homo sapiens
Manually annotated by BRENDA team
Haque, W.; Garg, A.; Agarwal, A.K.
Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy
Biochem. Biophys. Res. Commun.
327
446-453
2005
Homo sapiens
Manually annotated by BRENDA team
Agarwal, A.K.; Barnes, R.I.; Garg, A.
Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity
Arch. Biochem. Biophys.
449
64-76
2006
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Ye, G.M.; Chen, C.; Huang, S.; Han, D.D.; Guo, J.H.; Wan, B.; Yu, L.
Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7
DNA Seq.
16
386-390
2005
Homo sapiens (Q643R3), Homo sapiens
Manually annotated by BRENDA team
Gale, S.E.; Frolov, A.; Han, X.; Bickel, P.E.; Cao, L.; Bowcock, A.; Schaffer, J.E.; Ory, D.S.
A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation
J. Biol. Chem.
281
11082-11089
2006
Homo sapiens (O15120)
Manually annotated by BRENDA team
Yamashita, A.; Nakanishi, H.; Suzuki, H.; Kamata, R.; Tanaka, K.; Waku, K.; Sugiura, T.
Topology of acyltransferase motifs and substrate specificity and accessibility in 1-acyl-sn-glycero-3-phosphate acyltransferase 1
Biochim. Biophys. Acta
1771
1202-1215
2007
Homo sapiens (Q99943), Homo sapiens
Manually annotated by BRENDA team
Ghosh, A.K.; Ramakrishnan, G.; Chandramohan, C.; Rajasekharan, R.
CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid
J. Biol. Chem.
283
24525-24533
2008
Homo sapiens
Manually annotated by BRENDA team
Agarwal, A.K.; Sukumaran, S.; Bartz, R.; Barnes, R.I.; Garg, A.
Functional characterization of human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 9: cloning, tissue distribution, gene structure, and enzymatic activity
J. Endocrinol.
193
445-457
2007
Homo sapiens (Q8NF37), Homo sapiens
Manually annotated by BRENDA team
Schmidt, J.A.; Brown, W.J.
Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function
J. Cell Biol.
186
211-218
2009
Homo sapiens
Manually annotated by BRENDA team
Montero-Moran, G.; Caviglia, J.M.; McMahon, D.; Rothenberg, A.; Subramanian, V.; Xu, Z.; Lara-Gonzalez, S.; Storch, J.; Carman, G.M.; Brasaemle, D.L.
CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase
J. Lipid Res.
51
709-719
2009
Homo sapiens, Mus musculus, Mus musculus (Q9DBL9)
Manually annotated by BRENDA team
Sukumaran, S.; Barnes, R.I.; Garg, A.; Agarwal, A.K.
Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3
J. Mol. Endocrinol.
42
469-478
2009
Homo sapiens
Manually annotated by BRENDA team
Agarwal, A.K.; Sukumaran, S.; Cortes, V.A.; Tunison, K.; Mizrachi, D.; Sankella, S.; Gerard, R.D.; Horton, J.D.; Garg, A.
Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice
J. Biol. Chem.
286
37676-37691
2011
Homo sapiens (O15120), Homo sapiens (Q99943), Homo sapiens
Manually annotated by BRENDA team
Agarwal, A.K.; Garg, A.
Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers
J. Lipid Res.
51
2143-2152
2010
Homo sapiens (Q7L5N7), Homo sapiens
Manually annotated by BRENDA team
Prasad, S.S.; Garg, A.; Agarwal, A.K.
Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria
J. Lipid Res.
52
451-462
2011
Homo sapiens (Q9NRZ7), Homo sapiens (Q9NUQ2), Homo sapiens
Manually annotated by BRENDA team
Rastegar, F.; Gao, J.L.; Shenaq, D.; Luo, Q.; Shi, Q.; Kim, S.H.; Jiang, W.; Wagner, E.R.; Huang, E.; Gao, Y.; Shen, J.; Yang, K.; He, B.C.; Chen, L.; Zuo, G.W.; Luo, J.; Luo, X.; Bi, Y.; Liu, X.; Li, M.; Hu, N.; Wang, L.; Luther, G.; Luu, H.H.; Haydon, R.C.; He, T.C.
Lysophosphatidic acid acyltransferase beta (LPAATbeta) promotes the tumor growth of human osteosarcoma
PLoS ONE
5
e14182
2010
Homo sapiens (O15120), Homo sapiens
Manually annotated by BRENDA team
Blaskovich, M.A.; Yendluri, V.; Lawrence, H.R.; Lawrence, N.J.; Sebti, S.M.; Springett, G.M.
Lysophosphatidic acid acyltransferase beta regulates mTOR signaling
PLoS ONE
8
e78632
2013
Homo sapiens
Manually annotated by BRENDA team
Lee, J.; Ridgway, N.
Substrate channeling in the glycerol-3-phosphate pathway regulates the synthesis, storage and secretion of glycerolipids
Biochim. Biophys. Acta
1865
158438-158448
2020
Homo sapiens (O15120), Homo sapiens (Q99943), Homo sapiens (Q9NRZ5), Homo sapiens (Q9NRZ7), Homo sapiens (Q9NUQ2), Mus musculus (O35083), Mus musculus (Q8K3K7)
Manually annotated by BRENDA team