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acyl-CoA + dihydroxyacetone phosphate
CoA + acyldihydroxyacetone phosphate
acyl-CoA + glycerone phosphate
CoA + acylglycerone phosphate
palmitoyl-CoA + dihydroxyacetone phosphate
CoA + monopalmitoyldihydroxyacetone phosphate
recombinant in Saccharomyces cerevisiae cells
-
-
?
acyl-CoA + dihydroxyacetone phosphate
CoA + acyldihydroxyacetone phosphate
acyl-CoA + glycerone phosphate
CoA + acylglycerone phosphate
cis-9-hexadecenoyl-CoA + dihydroxyacetone phosphate
CoA + cis-9-hexadecenoyldihydroxyacetone phosphate
-
-
-
-
?
palmitoyl-CoA + dihydroxyacetone phosphate
CoA + monopalmitoyldihydroxyacetone phosphate
stearoyl-CoA + dihydroxyacetone phosphate
CoA + stearoyldihydroxyacetone phosphate
-
-
-
-
ir
tetradecanoyl-CoA + dihydroxyacetone phosphate
CoA + tetradecanoyldihydroxyacetone phosphate
-
i.e. myristoyl-CoA
-
-
?
additional information
?
-
acyl-CoA + dihydroxyacetone phosphate
CoA + acyldihydroxyacetone phosphate
-
-
?
acyl-CoA + dihydroxyacetone phosphate
CoA + acyldihydroxyacetone phosphate
-
-
-
?
acyl-CoA + glycerone phosphate
CoA + acylglycerone phosphate
-
-
-
?
acyl-CoA + glycerone phosphate
CoA + acylglycerone phosphate
-
-
-
-
?
acyl-CoA + dihydroxyacetone phosphate
CoA + acyldihydroxyacetone phosphate
-
-
-
?
acyl-CoA + dihydroxyacetone phosphate
CoA + acyldihydroxyacetone phosphate
-
-
-
?
acyl-CoA + dihydroxyacetone phosphate
CoA + acyldihydroxyacetone phosphate
-
-
-
ir
acyl-CoA + dihydroxyacetone phosphate
CoA + acyldihydroxyacetone phosphate
-
no acyl-acceptor is glycerol 3-phosphate
i.e. acylglycerone phosphate
?
acyl-CoA + glycerone phosphate
CoA + acylglycerone phosphate
-
-
-
-
?
acyl-CoA + glycerone phosphate
CoA + acylglycerone phosphate
-
enzyme is essential for biosynthesis of plasmalogens and nonetherlipids, the peroxisomal isozymes does not contribute to nonetherlipid biosynthesis
-
-
?
palmitoyl-CoA + dihydroxyacetone phosphate
CoA + monopalmitoyldihydroxyacetone phosphate
-
-
-
-
?
palmitoyl-CoA + dihydroxyacetone phosphate
CoA + monopalmitoyldihydroxyacetone phosphate
-
-
-
-
ir
palmitoyl-CoA + dihydroxyacetone phosphate
CoA + monopalmitoyldihydroxyacetone phosphate
-
best substrate
-
-
?
palmitoyl-CoA + dihydroxyacetone phosphate
CoA + monopalmitoyldihydroxyacetone phosphate
-
obligate precursor in ether lipids biosynthesis
-
ir
palmitoyl-CoA + dihydroxyacetone phosphate
CoA + monopalmitoyldihydroxyacetone phosphate
-
reaction in phosphatidic acid biosynthesis
-
ir
palmitoyl-CoA + dihydroxyacetone phosphate
CoA + monopalmitoyldihydroxyacetone phosphate
-
peroxisomal enzyme involved in ether lipid biosynthesis
-
-
?
additional information
?
-
-
enzyme activity is reduced with disorders: neonatal adrenoleukodystrophy, infantile Refsum disease, and hyperpipecolic acidemia
-
-
?
additional information
?
-
-
enzyme amount is reduced by 90% in Zellweger syndrome
-
-
?
additional information
?
-
-
enzyme amount is reduced by 90% in Zellweger syndrome
-
-
?
additional information
?
-
-
patients affected with rhizomelic chondrodysplasia punctata show reduced enzyme activity due to a defect in peroxisomal targeting
-
-
?
additional information
?
-
-
patients affected with rhizomelic chondrodysplasia punctata show reduced enzyme activity due to a defect in peroxisomal targeting
-
-
?
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Adrenoleukodystrophy
Dihydroxyacetone phosphate acyltransferase and alkyldihydroxyacetone phosphate synthase activities in rat liver subcellular fractions and human skin fibroblasts.
Carcinoma, Hepatocellular
Lipid composition of hepatitis B virus surface antigen particles and the particle-producing human hepatoma cell lines.
Carcinoma, Hepatocellular
Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis.
Chondrodysplasia Punctata
Abnormal myelination in peroxisomal isolated dihydroxyacetonephosphate acyltransferase deficiency.
Chondrodysplasia Punctata
Chondrodysplasia punctata with a mild clinical course.
Chondrodysplasia Punctata
X-linked dominant chondrodysplasia punctata with decreased dihydroxyacetone phosphate acyltransferase activity.
Chondrodysplasia Punctata, Rhizomelic
A new GNPAT variant of foetal rhizomelic chondrodysplasia punctata.
Chondrodysplasia Punctata, Rhizomelic
Chondrodysplasia punctata with a mild clinical course.
Chondrodysplasia Punctata, Rhizomelic
Clinical, biochemical, and molecular characterization of mild (nonclassic) rhizomelic chondrodysplasia punctata.
Chondrodysplasia Punctata, Rhizomelic
Dihydroxyacetone phosphate acyltransferase and alkyldihydroxyacetone phosphate synthase activities in rat liver subcellular fractions and human skin fibroblasts.
Chondrodysplasia Punctata, Rhizomelic
Drosophila Courtship Conditioning As a Measure of Learning and Memory.
Chondrodysplasia Punctata, Rhizomelic
Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities.
Chondrodysplasia Punctata, Rhizomelic
Functional characterization of novel mutations in GNPAT and AGPS, causing rhizomelic chondrodysplasia punctata (RCDP) types 2 and 3.
Chondrodysplasia Punctata, Rhizomelic
Genetic relationship between the Zellweger syndrome and other peroxisomal disorders characterized by an impairment in the assembly of peroxisomes.
Chondrodysplasia Punctata, Rhizomelic
Isolated dihydroxyacetonephosphate acyltransferase deficiency presenting with developmental delay.
Chondrodysplasia Punctata, Rhizomelic
Rhizomelic chondrodysplasia punctata with isolated DHAP-AT deficiency.
Chondrodysplasia Punctata, Rhizomelic
Rhizomelic chrondrodysplasia punctata type 2 resulting from paternal isodisomy of chromosome 1.
Demyelinating Diseases
Leukodystrophy caused by plasmalogen deficiency rescued by glyceryl 1-myristyl ether treatment.
glycerone-phosphate o-acyltransferase deficiency
Abnormal myelination in peroxisomal isolated dihydroxyacetonephosphate acyltransferase deficiency.
glycerone-phosphate o-acyltransferase deficiency
Etherphospholipid biosynthesis and dihydroxyactetone-phosphate acyltransferase: resolution of the genomic organization of the human gnpat gene and its use in the identification of novel mutations.
glycerone-phosphate o-acyltransferase deficiency
Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload.
glycerone-phosphate o-acyltransferase deficiency
Human dihydroxyacetonephosphate acyltransferase deficiency: a new peroxisomal disorder.
glycerone-phosphate o-acyltransferase deficiency
Isolated dihydroxyacetonephosphate acyltransferase deficiency presenting with developmental delay.
glycerone-phosphate o-acyltransferase deficiency
Isolated dihydroxyacetonephosphate-acyl-transferase deficiency in rhizomelic chondrodysplasia punctata: clinical presentation, metabolic and histological findings.
glycerone-phosphate o-acyltransferase deficiency
Neonatal punctate calcifications associated with maternal mixed connective tissue disorder (MCTD).
glycerone-phosphate o-acyltransferase deficiency
Rhizomelic chondrodysplasia punctata with isolated DHAP-AT deficiency.
glycerone-phosphate o-acyltransferase deficiency
Transformation and characterization of mutant human fibroblasts defective in peroxisome assembly.
Glycogen Storage Disease
Glycerolphosphate acyltransferase, dihydroxyacetonephosphate acyltransferase and carnitine palmitoyltransferase in a glycogen storage disease (gsd/gsd) rat.
Hemochromatosis
Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression.
Hemochromatosis
Further support for the association of GNPAT variant rs11558492 with severe iron overload in hemochromatosis.
Hemochromatosis
Glyceronephosphate O-acyltransferase as a hemochromatosis modifier gene: Another iron in the fire?
Hemochromatosis
GNPAT rs11558492 is not a Major Modifier of Iron Status: Study of Italian Hemochromatosis Patients and Blood Donors.
Hemochromatosis
GNPAT variant (D519G) is not associated with an elevated serum ferritin or iron removed by phlebotomy in patients referred for C282Y-linked hemochromatosis.
Hemochromatosis
GNPAT variant associated with severe iron overload in HFE hemochromatosis.
Hemochromatosis
Increased frequency of GNPAT p.D519G in compound HFE p.C282Y/p.H63D heterozygotes with elevated serum ferritin levels.
Hemochromatosis
The D519G Polymorphism of Glyceronephosphate O-Acyltransferase Is a Risk Factor for Familial Porphyria Cutanea Tarda.
Hemochromatosis
GNPAT variant (D519G) is not associated with an elevated serum ferritin or iron removed by phlebotomy in patients referred for C282Y-linked hemochromatosis.
Hepatomegaly
Effects of two peroxisome proliferators (ciprofibrate and fenofibrate) on peroxisomal membrane proteins and dihydroxyacetone-phosphate acyl-transferase activity in rat liver.
Hepatomegaly
Zellweger syndrome: diagnostic assays, syndrome delineation, and potential therapy.
Hyperferritinemia
GNPAT variant (D519G) is not associated with an elevated serum ferritin or iron removed by phlebotomy in patients referred for C282Y-linked hemochromatosis.
Hyperferritinemia
Increased frequency of GNPAT p.D519G in compound HFE p.C282Y/p.H63D heterozygotes with elevated serum ferritin levels.
Infertility, Male
Comparative studies of mitochondrial proteomics reveal an intimate protein network of male sterility in wheat (Triticum aestivum L.).
Infertility, Male
Using Transcriptome Analysis to Screen for Key Genes and Pathways Related to Cytoplasmic Male Sterility in Cotton (Gossypium hirsutum L.).
Iron Overload
Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression.
Iron Overload
Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload.
Iron Overload
Further support for the association of GNPAT variant rs11558492 with severe iron overload in hemochromatosis.
Iron Overload
GNPAT variant (D519G) is not associated with an elevated serum ferritin or iron removed by phlebotomy in patients referred for C282Y-linked hemochromatosis.
Iron Overload
GNPAT variant associated with severe iron overload in HFE hemochromatosis.
Iron Overload
GNPAT variant is not associated with severe iron overload in Irish C282Y homozygotes.
Iron Overload
Increased frequency of GNPAT p.D519G in compound HFE p.C282Y/p.H63D heterozygotes with elevated serum ferritin levels.
Iron Overload
GNPAT variant (D519G) is not associated with an elevated serum ferritin or iron removed by phlebotomy in patients referred for C282Y-linked hemochromatosis.
Liver Cirrhosis
GNPAT rs11558492 is not a Major Modifier of Iron Status: Study of Italian Hemochromatosis Patients and Blood Donors.
Melanoma
Identification of unique sensitizing targets for anti-inflammatory CDDO-Me in metastatic melanoma by a large-scale synthetic lethal RNAi screening.
Muscle Hypotonia
Zellweger syndrome: diagnostic assays, syndrome delineation, and potential therapy.
Neoplasms
Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis.
Neoplasms
Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism.
Neurologic Manifestations
Abnormal myelination in peroxisomal isolated dihydroxyacetonephosphate acyltransferase deficiency.
Parasitic Diseases
Peroxisomal function is altered during leishmania infection.
Peroxisomal Disorders
Congenital rubella syndrome associated with calcific epiphyseal stippling and peroxisomal dysfunction.
Peroxisomal Disorders
Developmental delay and growth failure caused by a peroxisomal disorder, dihydroxyacetonephosphate acyltransferase (DHAP-AT) deficiency.
Peroxisomal Disorders
Dihydroxyacetone phosphate acyltransferase.
Peroxisomal Disorders
Human dihydroxyacetonephosphate acyltransferase deficiency: a new peroxisomal disorder.
Peroxisomal Disorders
Measurement of dihydroxyacetone-phosphate acyltransferase (DHAPAT) in chorionic villous samples, blood cells and cultured cells.
Peroxisomal Disorders
Neonatal punctate calcifications associated with maternal mixed connective tissue disorder (MCTD).
Peroxisomal Disorders
[Chondrodysplasia punctata (the Conradi-Hünermann syndrome). A clinical case report and review of the literature]
Porphyria Cutanea Tarda
The D519G Polymorphism of Glyceronephosphate O-Acyltransferase Is a Risk Factor for Familial Porphyria Cutanea Tarda.
Porphyrias
The D519G Polymorphism of Glyceronephosphate O-Acyltransferase Is a Risk Factor for Familial Porphyria Cutanea Tarda.
Protein Deficiency
Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities.
Refsum Disease
Dihydroxyacetone phosphate acyltransferase and alkyldihydroxyacetone phosphate synthase activities in rat liver subcellular fractions and human skin fibroblasts.
Refsum Disease
Partial deficiency of dihydroxyacetone phosphate acyltransferase activity in both classical and infantile Refsum's diseases.
Refsum Disease, Infantile
Partial deficiency of dihydroxyacetone phosphate acyltransferase activity in both classical and infantile Refsum's diseases.
Starvation
A study of the glycerol phosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activities in rat liver mitochondrial and microsomal fractions. Relative distribution in parenchymal and non-parenchymal cells, effects of N-ethylmaleimide, palmitoyl-coenzyme A concentration, starvation, adrenalectomy and anti-insulin serum treatment.
Starvation
The activities of lipoprotein lipase and of enzymes involved in triacylglycerol synthesis in rat adipose tissue. Effects of starvation, dietary modification and of corticotropin injection.
Tuberculosis
The three-dimensional structure of N-succinyldiaminopimelate aminotransferase from Mycobacterium tuberculosis.
Zellweger Syndrome
A prenatal test for the cerebro-hepato-renal (Zellweger) syndrome by demonstration of the absence of catalase-containing particles (peroxisomes) in cultured amniotic fluid cells.
Zellweger Syndrome
Acyl-CoA oxidase, peroxisomal thiolase and dihydroxyacetone phosphate acyltransferase: aberrant subcellular localization in Zellweger syndrome.
Zellweger Syndrome
Biochemical and morphologic aspects of peroxisomes in the human rectal mucosa: diagnosis of Zellweger syndrome simplified by rectal biopsy.
Zellweger Syndrome
Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome, and rhizomelic chondrodysplasia punctata.
Zellweger Syndrome
Deficiency of enzymes catalyzing the biosynthesis of glycerol-ether lipids in Zellweger syndrome. A new category of metabolic disease involving the absence of peroxisomes.
Zellweger Syndrome
Diagnosis of Zellweger syndrome by rectal biopsy: immunoblot of peroxisomal beta-oxidation enzyme and activity of dihydroxyacetone phosphate acyltransferase in rectal mucosa.
Zellweger Syndrome
Neonatal punctate calcifications associated with maternal mixed connective tissue disorder (MCTD).
Zellweger Syndrome
Partial deficiency of dihydroxyacetone phosphate acyltransferase activity in both classical and infantile Refsum's diseases.
Zellweger Syndrome
Properties of the enzymes catalyzing the biosynthesis of lysophosphatidate and its ether analog in cultured fibroblasts from Zellweger syndrome patients and normal controls.
Zellweger Syndrome
Purification of peroxisomal acyl-CoA: dihydroxyacetonephosphate acyltransferase from human placenta.
Zellweger Syndrome
The cerebro-hepato-renal (Zellweger) syndrome: prenatal detection based on impaired biosynthesis of plasmalogens.
Zellweger Syndrome
Zellweger syndrome: diagnostic assays, syndrome delineation, and potential therapy.
Zellweger Syndrome
Zellweger-like syndrome with detectable hepatic peroxisomes: a variant form of peroxisomal disorder.
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Schutgens, R.B.H.; Romeyn, G.J.; Ofman, R.; Van den Bosch, H.; Tager, J.M.; Wanders, R.J.A.
Acyl-CoA:dihydroxyacetone phosphate acyltransferase in human skin fibroblasts: study of its properties using a new assay method [published erratum appears in Biochim Biophys Acta 1987 Sep 25;921(2):415]
Biochim. Biophys. Acta
879
286-291
1986
Homo sapiens
brenda
De Vet, E.C.J.M.; Ijlst, L.; Oostheim, W.; Dekker, C.; Moser, H.W.; Van den Bosch, H.; Wanders, R.J.A.
Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities
J. Lipid Res.
40
1998-2003
1999
Homo sapiens
brenda
Ofman, R.; Wanders, R.J.A.
Purification of peroxisomal acyl-CoA:dihydroxyacetonephosphate acyltransferase from human placenta
Biochim. Biophys. Acta
1206
27-34
1994
Homo sapiens
brenda
Thai, T.P.; Heid, H.; Rackwitz, H.R.; Hunziker, A.; Gorgas, K.; Just, W.W.
Ether lipid biosynthesis: isolation and molecular characterization of human dihydroxyacetonephosphate acyltransferase
FEBS Lett.
420
205-211
1997
Homo sapiens (O15228), Homo sapiens, Oryctolagus cuniculus
brenda
Hajra, A.K.
Dihydroxyacetone phosphate acyltransferase
Biochim. Biophys. Acta
1348
27-34
1997
Saccharomyces cerevisiae, Cavia porcellus, Oryctolagus cuniculus, Homo sapiens, no activity in Schizosaccharomyces pombe, Rattus norvegicus, Saccharomyces pastorianus
brenda
Ofman, R.; Hogenhout, E.M.; Wanders, R.J.
Identification and characterization of the mouse cDNA encoding acyl-CoA:dihydroxyacetone phosphate acyltransferase
Biochim. Biophys. Acta
1439
89-94
1999
Homo sapiens (O15228), Homo sapiens, Mus musculus
brenda
Liu, D.; Nagan, N.; Just, W.W.; Rodemer, C.; Thai, T.P.; Zoeller, R.A.
Role of dihydroxyacetonephosphate acyltransferase in the biosynthesis of plasmalogens and nonether glycerolipids
J. Lipid Res.
46
727-735
2005
Cricetulus griseus, Homo sapiens
brenda
Ebberink, M.S.; Mooyer, P.A.; Koster, J.; Dekker, C.J.; Eyskens, F.J.; Dionisi-Vici, C.; Clayton, P.T.; Barth, P.G.; Wanders, R.J.; Waterham, H.R.
Genotype-phenotype correlation in PEX5-deficient peroxisome biogenesis defective cell lines
Hum. Mutat.
30
93-98
2009
Homo sapiens
brenda
Piano, V.; Nenci, S.; Magnani, F.; Aliverti, A.; Mattevi, A.
Recombinant human dihydroxyacetonephosphate acyl-transferase characterization as an integral monotopic membrane protein
Biochem. Biophys. Res. Commun.
481
51-58
2016
Homo sapiens (O15228)
brenda
Gu, L.; Zhu, Y.; Lin, X.; Li, Y.; Cui, K.; Prochownik, E.; Li, Y.
Amplification of glyceronephosphate O-acyltransferase and recruitment of USP30 stabilize DRP1 to promote hepatocarcinogenesis
Cancer Res.
78
5808-5819
2018
Homo sapiens (O15228), Homo sapiens
brenda