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Information on EC 2.3.1.26 - sterol O-acyltransferase and Organism(s) Homo sapiens and UniProt Accession P35610
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2.3.1.26 sterol O-acyltransferaseIUBMB Comments
The enzyme catalyses the formation of sterol esters from a sterol and long-chain fatty acyl-coenzyme A. The enzyme from yeast, but not from mammals, prefers monounsaturated acyl-CoA. In mammals the enzyme acts mainly on cholesterol and forms cholesterol esters that are stored in cytosolic droplets, which may serve to protect cells from the toxicity of free cholesterol. In macrophages, the accumulation of cytosolic droplets of cholesterol esters results in the formation of `foam cells', a hallmark of early atherosclerotic lesions. In hepatocytes and enterocytes, cholesterol esters can be incorporated into apolipoprotein B-containing lipoproteins for secretion from the cell.
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Word Map
- 2.3.1.26
- keratinocytes
- lipoprotein
-
immortalize
- tnf
- dermal
- esterification
- psoriasis
-
esterify
- erk
- mapks
- chemokine
- collagen
-
atopic
-
uvb-induced
- nanoparticles
- atherosclerosis
- keratin
-
cosmetic
- dermatitis
- caspase-3
- drug development
-
radiation-induced
-
photoaging
-
macrophage-derived
- cox-2
- filaggrin
-
7alpha-hydroxylase
- hairless
-
sunscreen
- nutrition
-
scratch
- pharmacology
- sunburn
-
antiatherosclerotic
- phototoxicity
-
hypocholesterolemic
-
foam
- hmg-coa
-
photoprotective
-
desmogleins
-
dermatology
-
keratinocyte-derived
-
ad-like
-
suprabasal
- medicine
-
cholesterol-fed
-
hyperproliferation
-
transdermal
- mmp-1
- analysis
- imiquimod
-
uvb-irradiated
- involucrin
-
cyclobutane
-
re-epithelialization
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
hacat, acat1, acat2, acyl-coa:cholesterol acyltransferase, acat-1, acyl-coa cholesterol acyltransferase, soat1, cholesterol acyltransferase, acyl-coenzyme a:cholesterol acyltransferase, acat-2, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ACAT
ACAT-2
ACAT2
acyl coenzyme A-cholesterol-O-acyltransferase
-
-
-
-
acyl-CoA:cholesterol acyltransferase
acyl-CoA:cholesterol acyltransferase 2
acylcoenzyme A:cholesterol O-acyltransferase
-
-
-
-
acyltransferase, cholesterol
-
-
-
-
cholesterol acyltransferase
-
-
-
-
cholesterol ester synthase
-
-
-
-
cholesterol ester synthetase
-
-
-
-
cholesteryl ester synthetase
-
-
-
-
hACAT-2
Soat2
sterol-ester synthase
-
-
-
-
sterol-ester synthetase
-
-
-
-
ACAT
-
-
-
-
acyl-CoA:cholesterol acyltransferase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
Acyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
long-chain acyl-CoA:sterol O-acyltransferase
The enzyme catalyses the formation of sterol esters from a sterol and long-chain fatty acyl-coenzyme A. The enzyme from yeast, but not from mammals, prefers monounsaturated acyl-CoA. In mammals the enzyme acts mainly on cholesterol and forms cholesterol esters that are stored in cytosolic droplets, which may serve to protect cells from the toxicity of free cholesterol. In macrophages, the accumulation of cytosolic droplets of cholesterol esters results in the formation of `foam cells', a hallmark of early atherosclerotic lesions. In hepatocytes and enterocytes, cholesterol esters can be incorporated into apolipoprotein B-containing lipoproteins for secretion from the cell.
CAS REGISTRY NUMBER
COMMENTARY
9027-63-8
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 24(S)-hydroxycholesterol
CoA + acyl (24S)-24-hydroxycholesterol
-
-
-
?
pregnenolone + oleoyl-CoA
20-oxopregn-5-en-3beta-yl (9Z)-octadec-9-enoate + CoA
without cholesterol, pregnenolone is a poor ACAT substrate, with cholesterol, the Vmax for PREG esterification increases by 100fold
-
-
?
docosahexaenoyl-CoA + cholesterol
CoA + cholesteryl docosahexaenoate
-
rate of cholesteryl ester formation is faster and more cholesteryl ester is formed with oleic acid compared to docosahexanoic acid. Docosahexanoic acid substantially reduces cholesteryl ester formation when given in combination with oleic acid
-
-
?
oleoyl-CoA + 5alpha,6alpha-epoxycholesterol
CoA + 5alpha,6alpha-epoxycholesteryl oleate
-
activity comparable to cholesterol
-
-
?
oleoyl-CoA + 7alpha-hydroxycholesterol
CoA + 7alpha-hydroxycholesteryl oleate
-
activity comparable to cholesterol
-
-
?
pregnenolone + oleoyl-CoA
20-oxopregn-5-en-3beta-yl (9Z)-octadec-9-enoate + CoA
without cholesterol, pregnenolone is a poor ACAT substrate, with cholesterol, the Vmax for pregnenolone esterification increases by 100fold
-
-
?
acyl-CoA + cholesterol
CoA + cholesterol ester
ACAT-1 plays an important role in the formation of macrophage-derived foam cells in atherosclerotic lesions
-
-
?
acyl-CoA + cholesterol
CoA + cholesterol ester
cholesterol is the preferred acceptor substrate, and for ACAT1, the preferred fatty acyl-CoA is oleoyl coenzyme A
-
-
?
oleoyl-CoA + cholesterol
CoA + cholesteryl oleate
cholesterol is the preferred acceptor substrate, and for ACAT1, the preferred fatty acyl-CoA is oleoyl coenzyme A
-
-
?
acyl-CoA + cholesterol
CoA + cholesterol ester
-
-
684773, 684780, 684786, 684799, 684800, 684882, 685566, 685611, 685899, 686600, 688060, 688139, 688767, 689426, 736937
-
-
?
acyl-CoA + cholesterol
CoA + cholesterol ester
cholesterol is the preferred acceptor substrate
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
may play an important role in regulation of the accumulation of cholesterol esters within smooth muscle cells of the artery wall during atherogenesis and in synthesis of cholesterol esters during hepatic very low-density lipoprotein synthesis and secretion
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
responsible for cellular synthesis of cholesterol esters in various cell types
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
the enzyme is relevant for cellular cholesterol esterification in vivo, the regulation in human mononuclear phagocytes indicates that the enzyme is also involved in foam cell formation during early atherogenesis
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
the high activity of intestinal enzyme renders it possible that the enzyme plays a role in cholesterol absorption
-
?
oleoyl-CoA + cholesterol
?
-
activity assay
-
-
?
oleoyl-CoA + cholesterol
CoA + cholesteryl oleate
-
recombinant enzyme
-
?
oleoyl-CoA + cholesterol
CoA + cholesteryl oleate
-
the dimeric enzyme responds to cholesterol in essentially the same manner as the tetrameric enzyme
-
?
oleoyl-CoA + cholesterol
CoA + cholesteryl oleate
-
rate of cholesteryl ester formation is faster and more cholesteryl ester is formed with oleic acid compared to docosahexanoic acid. Docosahexanoic acid substantially reduces cholesteryl ester formation when given in combination with oleic acid
-
-
?
oleoyl-CoA + cholesterol
CoA + cholesteryl oleate
-
intrinsic fluorescence spectroscopy is used to study the binding between the enzyme and its substrates in CHAPS/phospholipid mixed micelles. Results show that oleoyl-CoA binds to ACAT1 with Kd=1.9 µM and elicits significant structural changes of the protein as manifested by the significantly positive changes in its fluorescence spectrum
-
-
?
oleoyl-CoA + ergosterol
CoA + ergosteryl oleate
-
recombinant enzyme: restores ergosteryl oleate formation in vivo to only approximately 8% of that catalysed by yeast enzyme in wild-type cells
-
-
?
additional information
?
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
when assayed in reconstituted liposomes or in mixed micelles, the purified recombinant enzyme responds to cholesterol as its substrate in a sigmoidal manner. When pregnenolone and cholesterol (or other sterol analogues) are both present, binding of cholesterol at site A causes conformational changes, enabling the enzyme to increase the rate of esterification reaction much more efficiently
-
-
?
additional information
?
-
when assayed in reconstituted liposomes or in mixed micelles, the purified recombinant enzyme responds to cholesterol as its substrate in a sigmoidal manner. When pregnenolone and cholesterol (or other sterol analogues) are both present, binding of cholesterol at site A causes conformational changes, enabling the enzyme to increase the rate of esterification reaction much more efficiently
-
-
?
additional information
?
-
-
when assayed in reconstituted liposomes or in mixed micelles, the purified recombinant enzyme responds to cholesterol as its substrate in a sigmoidal manner. When pregnenolone and cholesterol (or other sterol analogues) are both present, binding of cholesterol at site A causes conformational changes, enabling the enzyme to increase the rate of esterification reaction much more efficiently
-
-
?
additional information
?
-
-
oleic acid is not incorporated into cholesterol esters by placental microsomes even in the presence of ATP, CoA and MgCl2
-
-
?
additional information
?
-
-
enzyme activity is regulated by the acyl-CoA binding protein ACBP
-
-
?
additional information
?
-
-
stereochemistry of 3-hydroxyl group at steroid ring is a critical structural feature for ACAT1 isoform
-
-
?
additional information
?
-
-
very poor substrates: 7-ketocholesterol, 7beta-hydroxycholesterol, 5beta,6beta-epoxycholesterol, 24(S),25-epoxycholesterol
-
-
?
additional information
?
-
ACAT2 plays an important role in intestinal cholesterol absorption
-
-
?
additional information
?
-
-
ACAT2 plays an important role in intestinal cholesterol absorption
-
-
?
additional information
?
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acyl-CoA + cholesterol
CoA + cholesterol ester
ACAT-1 plays an important role in the formation of macrophage-derived foam cells in atherosclerotic lesions
-
-
?
acyl-CoA + cholesterol
CoA + cholesterol ester
-
-
684773, 684780, 684786, 684799, 684800, 684882, 685566, 685611, 685899, 686600, 688060, 688139, 688767, 689426, 736937
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
-
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
may play an important role in regulation of the accumulation of cholesterol esters within smooth muscle cells of the artery wall during atherogenesis and in synthesis of cholesterol esters during hepatic very low-density lipoprotein synthesis and secretion
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
responsible for cellular synthesis of cholesterol esters in various cell types
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
the enzyme is relevant for cellular cholesterol esterification in vivo, the regulation in human mononuclear phagocytes indicates that the enzyme is also involved in foam cell formation during early atherogenesis
-
?
long-chain fatty acyl-CoA + cholesterol
CoA + cholesteryl long-chain fatty acyl ester
-
the high activity of intestinal enzyme renders it possible that the enzyme plays a role in cholesterol absorption
-
?
additional information
?
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
additional information
?
-
-
the enzyme contains two different binding sites for steroidal molecules. In addition to cholesterol, other sterols that possess the 3-beta OH at C-3, including pregnenolone, oxysterols such as 24(S)-hydroxycholesterol and 27-hydroxycholesterol, etc., and various plant sterols, can all be ACAT substrates. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-2-(2-methoxyphenyl)-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
-
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-chlorobenzoate
-
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-cyanobenzoate
-
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-fluorobenzoate
-
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-methoxybenzoate
-
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-bromobenzoate
-
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-chlorobenzoate
-
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-cyanobenzoate
-
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-fluorobenzoate
-
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-methoxybenzoate
-
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-bromobenzoate
-
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-chlorobenzoate
-
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-formylbenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-methoxybenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-nitrobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(naphthalen-2-yl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,4-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,6-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2-fluorophenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-(propanoyloxy)-4-[(propanoyloxy)methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-12-hydroxy-4,6a,12b-trimethyl-3-[(2-methylpropanoyl)oxy]-4-[[(2-methylpropanoyl)oxy]methyl]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-(propylcarbamoyl)-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-[(propanoyloxy)methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-[[(3-phenylpropanoyl)oxy]methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-4-[[(2-methylpropanoyl)oxy]methyl]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4-[(2-methoxy-2-oxoethyl)carbamoyl]-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(2-ethoxy-2-oxoethyl)carbamoyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2,3,4-trifluorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-chlorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-fluorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-iodobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-methoxybenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-methylbenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-(methylsulfanyl)benzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-bromobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-chlorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-ethenylbenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-methoxybenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-methylbenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-nitrobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-iodobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-methoxybenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-methylbenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(2lambda~5~-triaza-1,2-dien-2-yl)benzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(methylsulfanyl)benzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-aminobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromo-2-fluorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromo-3-fluorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-chloro-2-iodobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-chlorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyano-3-fluorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-ethenylbenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-ethylbenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-fluorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-hydroxybenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-iodobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-methoxybenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-nitrobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[[(2,4-dimethoxyphenyl)methyl]carbamoyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-6-[(4-cyanobenzoyl)oxy]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-carboxylic acid
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(benzoyloxy)-4-[(benzoyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(hexanoyloxy)-4-[(hexanoyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-(propanoyloxy)-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-[(phenylacetyl)oxy]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-3-[(2-methylpropanoyl)oxy]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl 2-methylpropanoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl 3-phenylpropanoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl propanoate
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(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2,2-difluoro-2H-1,3-benzodioxole-5-carboxylate
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(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(1-benzothiophen-2-yl)benzoate
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(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-methylbenzoate
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(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 5,8-dihydronaphthalene-2-carboxylate
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(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl benzoate
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(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl naphthalene-1-carboxylate
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(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl [1,1'-biphenyl]-4-carboxylate
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2-[(2E,6Z,8E,10E)-dodeca-2,6,8,10-tetraenoylamino]-1,1-dimethylethyl acetate
IC50: 0.0281 mM
5-(1-butoxy-2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}propyl)-1,3-benzodioxole
IC50: 0.017 mM
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-ethoxypropyl)-1,3-benzodioxole
IC50: 0.031 mM
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-methoxypropyl)-1,3-benzodioxole
IC50: 0.035 mM
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-propoxypropyl)-1,3-benzodioxole
IC50: 0.014 mM
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(heptyloxy)propyl]-1,3-benzodioxole
IC50: 0.05 mM
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(hexyloxy)propyl]-1,3-benzodioxole
IC50: 0.034 mM
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(nonyloxy)propyl]-1,3-benzodioxole
0.125 mM, 25% inhibition
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(octyloxy)propyl]-1,3-benzodioxole
0.125 mM: 44% inhibition
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(pentyloxy)propyl]-1,3-benzodioxole
IC50: 0.02 mM
beauveriolide I
selectively inhibits isoform SOAT1 in a cell-based assay, and shows dual inhibition of SOAT1 and SOAT2 in the enzyme-based assay
beauveriolide III
selectively inhibits isoform SOAT1 in a cell-based assay, and shows dual inhibition of SOAT1 and SOAT2 in the enzyme-based assay . Beauveriolide III binds to a putative active site responsible for SOAT1 that is located on the cytosolic side of the ER, while Beauveriolide III is not accessible to the corresponding active site for SOAT2 located on the luminal side
biseokeaniamide B
exhibits moderate cytotoxicity against HeLa cancer cells
celludinone A1
an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay
celludinone A2
an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay
celludinone B
an indanone produced by Talaromyces cellulolyticus BF-0307, selectively inhibits the SOAT2 isoform
methyl (3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-6-[(4-cyanobenzoyl)oxy]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-carboxylate
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octyl beta-D-glucopyranoside
presence of octylglucoside dissociates ACAT1 to form a dimeric species
Triton X-100
presence of Triton X-100 dissociates ACAT1 to form a dimeric species
[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl 2-methylpropanoate
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[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl 3-phenylpropanoate
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[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl propanoate
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(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl (9Z,12E)-octadeca-9,12-dienoate
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(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 3-methylbutanoate
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(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl benzoate
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(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl butanoate
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(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pent-4-enoate
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(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pentanoate
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(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl propanoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-2-(2-methoxyphenyl)-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-chlorobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-fluorobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-methoxybenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-bromobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-chlorobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-fluorobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-methoxybenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-bromobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-chlorobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-formylbenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-methoxybenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-nitrobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(naphthalen-2-yl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,4-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,6-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2-fluorophenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
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(2S)-2-[(5aR,6R,8R,9aR,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]propane-1,2-diyl diacetate
compound exhibits potent activity against isoform ACAT2 and greater selectivity for ACAT2 than for ACAT1, ratio of IC50 value for ACTA1/ACAT2 is above 1000
(3S,4aR,6S,6aS,12R,12aS,12bS)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-(propanoyloxy)-4-[(propanoyloxy)methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-12-hydroxy-4,6a,12b-trimethyl-3-[(2-methylpropanoyl)oxy]-4-[[(2-methylpropanoyl)oxy]methyl]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-(propylcarbamoyl)-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-[(propanoyloxy)methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-[[(3-phenylpropanoyl)oxy]methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-4-[[(2-methylpropanoyl)oxy]methyl]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4-[(2-methoxy-2-oxoethyl)carbamoyl]-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(2-ethoxy-2-oxoethyl)carbamoyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2,3,4-trifluorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-chlorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-fluorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-iodobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-methoxybenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-methylbenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-(methylsulfanyl)benzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-bromobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-chlorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-cyanobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-ethenylbenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-methoxybenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-methylbenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-nitrobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-iodobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-methoxybenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-methylbenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(2lambda~5~-triaza-1,2-dien-2-yl)benzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(methylsulfanyl)benzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-aminobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromo-2-fluorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromo-3-fluorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-chloro-2-iodobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-chlorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyano-3-fluorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-ethenylbenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-ethylbenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-fluorobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-hydroxybenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-iodobenzoate
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(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-methoxybenzoate
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-nitrobenzoate
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[[(2,4-dimethoxyphenyl)methyl]carbamoyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-6-[(4-cyanobenzoyl)oxy]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-carboxylic acid
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(benzoyloxy)-4-[(benzoyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(hexanoyloxy)-4-[(hexanoyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-(propanoyloxy)-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-[(phenylacetyl)oxy]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-3-[(2-methylpropanoyl)oxy]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl 2-methylpropanoate
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl 3-phenylpropanoate
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl propanoate
-
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2,2-difluoro-2H-1,3-benzodioxole-5-carboxylate
-
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(1-benzothiophen-2-yl)benzoate
-
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-methylbenzoate
-
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 5,8-dihydronaphthalene-2-carboxylate
-
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl benzoate
-
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl naphthalene-1-carboxylate
-
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl [1,1'-biphenyl]-4-carboxylate
-
2,3,6,8-tetramethoxy-5-(piperidin-1-ylsulfonyl)-1,4-dihydro-9H-xanthen-9-one
-
10 microgram/ml, 10.53% inhibition
2,3,6,8-tetramethoxy-5-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)sulfonyl]-1,4-dihydro-9H-xanthen-9-one
-
10 microgram/ml, 51.34% inhibition
2,3,6,8-tetramethoxy-5-{[4-(3-methylphenyl)piperazin-1-yl]sulfonyl}-1,4-dihydro-9H-xanthen-9-one
-
10 microgram/ml, 64.8% inhibition
2,3,6,8-tetramethoxy-5-{[4-(4-methoxyphenyl)piperazin-1-yl]sulfonyl}-1,4-dihydro-9H-xanthen-9-one
-
10 microgram/ml, 36.92% inhibition
2,3,6,8-tetramethoxy-5-{[4-(pyridin-2-yl)piperazin-1-yl]sulfonyl}-1,4-dihydro-9H-xanthen-9-one
-
10 microgram/ml, 43.56% inhibition
2,3,6,8-tetramethoxy-9-oxo-N-(2-phenylpropyl)-4,9-dihydro-1H-xanthene-5-sulfonamide
-
10 microgram/ml, 10.78% inhibition
2,3,6,8-tetramethoxy-N-(naphthalen-2-ylmethyl)-9-oxo-4,9-dihydro-1H-xanthene-5-sulfonamide
-
10 microgram/ml, 25% inhibition
2-[(2E,6Z,8E,10E)-dodeca-2,6,8,10-tetraenoylamino]-1,1-dimethylethyl acetate
IC50: 0.0875 mM
2-[(5aR,6R,8R,9aR,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
-
-
2-[(5aR,6R,8R,9aR,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
-
-
2-[(5aS,6S,8S,9aS)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
-
-
2-[(5aS,6S,8S,9aS,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
-
-
2-[(5aS,6S,8S,9aS,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
-
-
2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide
-
K-604
2alpha,3beta,23-trihydroxyolean-12-en-28-oic acid
-
arjunolic acid, at 0.1 mg/ml, 60.8% inhibition of isoform ACAT1, 5.3% inhibition of isoform ACAT2
2alpha,3beta-dihydroxyolean-12-en-28-oic acid
-
maslinic acid, at 0.1 mg/ml, 46.2% inhibition of isoform ACAT1, 17.3% inhibition of isoform ACAT2
2alpha,3beta-dihydroxyurs-12-en-28-oic acid
-
corosolic acid, at 0.1 mg/ml, 46.7% inhibition of isoform ACAT1, 3% inhibition of isoform ACAT2
3beta,23-dihydroxyurs-12-en-28-oic acid
-
23-hydroxyursolic acid, at 0.1 mg/ml, 41.5% inhibition of isoform ACAT1, 22.2% inhibition of isoform ACAT2
3beta-hydroxyolean-12-en-28-oic acid
-
oleanoic acid, at 0.1 mg/ml, 22.6% inhibition of isoform ACAT1, 10.2% inhibition of isoform ACAT2
3beta-hydroxyurs-12-en-28-al
-
ursolic aldehyde, at 0.1 mg/ml, 21.8% inhibition of isoform ACAT1, 13% inhibition of isoform ACAT2
3beta-hydroxyurs-12-en-28-oic acid
-
ursolic acid, at 0.1 mg/ml, 23.1% inhibition of isoform ACAT1, 16.7% inhibition of isoform ACAT2
5-(1-butoxy-2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}propyl)-1,3-benzodioxole
0.125 mM, 28% inhibition
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-ethoxypropyl)-1,3-benzodioxole
0.125 mM, 29% inhibition
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-methoxypropyl)-1,3-benzodioxole
0.125 mM, 45% inhibition
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-propoxypropyl)-1,3-benzodioxole
0.125 mM, 33% inhibition
5-[(4-aminopiperazin-1-yl)sulfonyl]-2,3,6,8-tetramethoxy-1,4-dihydro-9H-xanthen-9-one
-
10 microgram/ml, 14.5% inhibition
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(heptyloxy)propyl]-1,3-benzodioxole
0.125 mM, 26% inhibition
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(hexyloxy)propyl]-1,3-benzodioxole
0.125 mM, 33% inhibition
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(nonyloxy)propyl]-1,3-benzodioxole
0.125 mM, 10% inhibition
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(octyloxy)propyl]-1,3-benzodioxole
0.125 mM: 19% inhibition
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(pentyloxy)propyl]-1,3-benzodioxole
0.125 mM, 33% inhibition
5-{[(2R,6S)-2,6-dimethylmorpholin-4-yl]sulfonyl}-2,3,6,8-tetramethoxy-1,4-dihydro-9H-xanthen-9-one
-
10 microgram/ml, 8.84% inhibition
5-{[3-(dimethylamino)pyrrolidin-1-yl]sulfonyl}-2,3,6,8-tetramethoxy-1,4-dihydro-9H-xanthen-9-one
-
10 microgram/ml, 20.96% inhibition
biseokeaniamide B
exhibits moderate cytotoxicity against HeLa cancer cells
celludinone A1
an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay
celludinone A2
an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay
celludinone B
an indanone produced by Talaromyces cellulolyticus BF-0307, selectively inhibits the SOAT2 isoform
ethyl 1-[(2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthen-5-yl)sulfonyl]piperidine-3-carboxylate
-
10 microgram/ml, 7.99% inhibition
ethyl N-methyl-N-[(2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthen-5-yl)sulfonyl]glycinate
-
10 microgram/ml, 16.79% inhibition
methyl (3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-6-[(4-cyanobenzoyl)oxy]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-carboxylate
-
methyl N-[(2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthen-5-yl)sulfonyl]glycinate
-
10 microgram/ml, 5.13% inhibition
N,N-diethyl-1-[(2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthen-5-yl)sulfonyl]piperidine-3-carboxamide
-
10 microgram/ml, 12.59% inhibition
N-(3-chlorobenzyl)-2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthene-5-sulfonamide
-
10 microgram/ml, 15.76% inhibition
N-(4,6-dimethyl-1-pentylindolin-7-yl)-2,2-dimethylpropanamide
-
KY-455, an anti-oxidative ACAT inhibitor
N-(4-amino-2, 6-diisopropylphenyl)-N'-[1-butyl-4-[3-(3-hydroxypropoxy) phenyl]-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl] urea hydrochloride monohydrate
-
SMP-797
N-(4-fluorobenzyl)-2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthene-5-sulfonamide
-
10 microgram/ml, 10.24% inhibition
N-(benzyloxy)-2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthene-5-sulfonamide
-
10 microgram/ml, 16.76% inhibition
N-[2-(3,4-dimethylphenyl)ethyl]-2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthene-5-sulfonamide
-
10 microgram/ml, 11.86% inhibition
N-[3-(3,4-dimethoxyphenyl)propyl]-2,3,6,8-tetramethoxy-N-methyl-9-oxo-4,9-dihydro-1H-xanthene-5-sulfonamide
-
10 microgram/ml, 30.06% inhibition
naphthalene-1-carboxylic acid [3-(6-bromo-imidazo[1,2-a]pyridin-2-yl)-phenyl]-amide
-
48% inhibition at 0.025 mg/ml
naphthalene-2-carboxylic acid (3-[6-(2,4-difluoro-phenyl)-imidazo[1,2-a]pyridin-2-yl]-phenyl)-amide
-
23.6% inhibition at 0.025 mg/ml
naphthalene-2-carboxylic acid [3-(6-bromo-imidazo[1,2-a]pyridin-2-yl)-phenyl]-amide
-
56% inhibition at 0.025 mg/ml
naphthalene-2-carboxylic acid [3-(6-naphtalen-2-yl-imidazo-[1,2-a]pyridin-2-yl)-phenyl]-amide
-
7.1% inhibition at 0.025 mg/ml
p-chloromercuribenzene sulfonic acid
-
50% inhibition of ACAT1 at 0.01 mM, Cys467 is one of the major targets for inhibition
[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl 2-methylpropanoate
-
[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl 3-phenylpropanoate
-
[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl propanoate
-
[4-(2-(3-[(naphthalene-2-carbonyl)-amino]-phenyl)-imidazo[1,2-a]pyridin-6-yl)-phenoxy]-acetic acid
-
15% inhibition at 0.025 mg/ml
[4-(2-(3-[(naphthalene-2-carbonyl)-amino]-phenyl)-imidazo[1,2-a]pyridin-6-yl)-phenoxy]-acetic acid ethyl ester
-
8.7% inhibition at 0.025 mg/ml
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
-
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
-
CI-976
-
cell-free extract of sat1 and sat2 cells: more than 95% inhibition at 0.2 mM, intact sat1 and sat2 cells: approximately 75-80% inhibition at 0.2 mM
DuP 128
-
50% inhibition at 0.00013 mM for HisACAT1, 50% inhibition at 0.0001 mM for the mutants HisACAT1/p64 and HisACAT1/1-65
additional information
development of potent and isozyme-selective inhibitors toward acyl-CoA:cholesterol acyltransferase 2, ACAT2, synthesis of pyripyropene A derivatives with a 7-O-substituted benzoyl substituent that significantly exhibit more potent ACAT2 inhibitory activity and higher ACAT2 isozyme selectivity than pyripyropene A, structure-activity relationship of pyripyropene A derivatives as potent and selective ACAT2 inhibitors, overview
-
additional information
development of potent and isozyme-selective inhibitors toward acyl-CoA:cholesterol acyltransferase 2, ACAT2, synthesis of pyripyropene A derivatives with a 7-O-substituted benzoyl substituent that significantly exhibit more potent ACAT2 inhibitory activity and higher ACAT2 isozyme selectivity than pyripyropene A, structure-activity relationship of pyripyropene A derivatives as potent and selective ACAT2 inhibitors, overview
-
additional information
development of potent and isozyme-selective inhibitors toward acyl-CoA:cholesterol acyltransferase 2, ACAT2, synthesis of pyripyropene A derivatives with a 7-O-substituted benzoyl substituent that significantly exhibit more potent ACAT2 inhibitory activity and higher ACAT2 isozyme selectivity than pyripyropene A, structure-activity relationship of pyripyropene A derivatives as potent and selective ACAT2 inhibitors, overview
-
additional information
development of potent and isozyme-selective inhibitors toward acyl-CoA:cholesterol acyltransferase 2, ACAT2, synthesis of pyripyropene A derivatives with a 7-O-substituted benzoyl substituent that significantly exhibit more potent ACAT2 inhibitory activity and higher ACAT2 isozyme selectivity than pyripyropene A, structure-activity relationship of pyripyropene A derivatives as potent and selective ACAT2 inhibitors, overview
-
additional information
synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase inhibitors, overview
-
additional information
synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase inhibitors, overview
-
additional information
-
corticosterone, cortisol and estriol have little effect, enzyme activity in placenta may be regulated by endogenously synthesized steroid hormones
-
additional information
-
design and synthesis of simple, potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2), overview. Natural product pyripyropene A (PPPA) and its analogues are the only chemical type ACAT2-specific inhibitors and are isolated from the fungal strain Aspergillus fumigatus strain FO-12897
-
additional information
development of potent and isozyme-selective inhibitors toward acyl-CoA:cholesterol acyltransferase 2, ACAT2, synthesis of pyripyropene A derivatives with a 7-O-substituted benzoyl substituent that significantly exhibit more potent ACAT2 inhibitory activity and higher ACAT2 isozyme selectivity than pyripyropene A, structure-activity relationship of pyripyropene A derivatives as potent and selective ACAT2 inhibitors, overview
-
additional information
development of potent and isozyme-selective inhibitors toward acyl-CoA:cholesterol acyltransferase 2, ACAT2, synthesis of pyripyropene A derivatives with a 7-O-substituted benzoyl substituent that significantly exhibit more potent ACAT2 inhibitory activity and higher ACAT2 isozyme selectivity than pyripyropene A, structure-activity relationship of pyripyropene A derivatives as potent and selective ACAT2 inhibitors, overview
-
additional information
development of potent and isozyme-selective inhibitors toward acyl-CoA:cholesterol acyltransferase 2, ACAT2, synthesis of pyripyropene A derivatives with a 7-O-substituted benzoyl substituent that significantly exhibit more potent ACAT2 inhibitory activity and higher ACAT2 isozyme selectivity than pyripyropene A, structure-activity relationship of pyripyropene A derivatives as potent and selective ACAT2 inhibitors, overview
-
additional information
development of potent and isozyme-selective inhibitors toward acyl-CoA:cholesterol acyltransferase 2, ACAT2, synthesis of pyripyropene A derivatives with a 7-O-substituted benzoyl substituent that significantly exhibit more potent ACAT2 inhibitory activity and higher ACAT2 isozyme selectivity than pyripyropene A, structure-activity relationship of pyripyropene A derivatives as potent and selective ACAT2 inhibitors, overview
-
additional information
synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors, overview
-
additional information
synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors, overview
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
6-ketocholestanol
-
added at high concentration causes modest increase in enzyme activity
7-ketocholesterol
-
added at high concentration causes modest increase in enzyme activity
liver fatty acid binding protein/bovine serum albumin
-
small increase in activity
-
cholesterol
-
addition of cholesterol to frozen microsomes prepared from unfrozen liver tissue increases the enzyme activity
cholesterol
-
serves as an enzyme activator in vitro, in addition to its role as an enzyme substrate
cholesterol
-
exogenous cholesterol in the liposomes is absolutely necessary for activity of the reconstituted enzyme
cholesterol
-
addition of cholesterol to microsomes prepared from frozen liver tissue does not further increase the enzyme activity
cholesterol
-
presence of cholesterol stimulates reaction of ACAT1 with sitosterol up to 3fold, reaction of ACAT2 is only moderately activated
cholesterol
-
significant activation of reaction with 7-ketocholesterol as substrate, decrease in Hill coefficient from 3.0 without cholesterol to 1.1 with cholesterol
additional information
enzyme ACAT1 can be activated by a variety of sterols. All sterols that possess the iso-octyl side chain including cholesterol, oxysterols, various plant sterols can all be activators of ACAT. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates. When pregnenolone and cholesterol (or other sterol analogues) are both present, binding of cholesterol at site A causes conformational changes, enabling the enzyme to increase the rate of esterification reaction much more efficiently
-
additional information
enzyme ACAT1 can be activated by a variety of sterols. All sterols that possess the iso-octyl side chain including cholesterol, oxysterols, various plant sterols can all be activators of ACAT. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates. When pregnenolone and cholesterol (or other sterol analogues) are both present, binding of cholesterol at site A causes conformational changes, enabling the enzyme to increase the rate of esterification reaction much more efficiently
-
additional information
-
enzyme ACAT1 can be activated by a variety of sterols. All sterols that possess the iso-octyl side chain including cholesterol, oxysterols, various plant sterols can all be activators of ACAT. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates. When pregnenolone and cholesterol (or other sterol analogues) are both present, binding of cholesterol at site A causes conformational changes, enabling the enzyme to increase the rate of esterification reaction much more efficiently
-
additional information
enzyme ACAT1 can be activated by a variety of sterols. All sterols that possess the iso-octyl side chain including cholesterol, oxysterols, various plant sterols can all be activators of ACAT. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
additional information
enzyme ACAT1 can be activated by a variety of sterols. All sterols that possess the iso-octyl side chain including cholesterol, oxysterols, various plant sterols can all be activators of ACAT. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
additional information
-
enzyme ACAT1 can be activated by a variety of sterols. All sterols that possess the iso-octyl side chain including cholesterol, oxysterols, various plant sterols can all be activators of ACAT. Pregnenolone can only be an ACAT substrate because it lacks the iso-octyl side chain required to be an ACAT activator. The unnatural cholesterol analogs epi-cholesterol (with 3-alpha OH in steroid ring B) and ent-cholesterol (the mirror image of cholesterol) contain the iso-octyl side chain but do not have the 3-beta OH at C-3. Thus, they can only serve as activators and cannot serve as substrates
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0012
pregnenolone
pH 7.4, 37°C, with cholesterol (0.32 mM). Without cholesterol, the Km for pregnenolone is too high to be measurable
additional information
additional information
ACAT1 is an allosteric enzyme, modeling, overview. When assayed in reconstituted liposomes or in mixed micelles, the purified recombinant enzyme responds to cholesterol as its substrate in a sigmoidal manner, kinetic analysis
-
additional information
additional information
ACAT1 is an allosteric enzyme, modeling, overview. When assayed in reconstituted liposomes or in mixed micelles, the purified recombinant enzyme responds to cholesterol as its substrate in a sigmoidal manner, kinetic analysis
-
additional information
additional information
-
ACAT1 is an allosteric enzyme, modeling, overview. When assayed in reconstituted liposomes or in mixed micelles, the purified recombinant enzyme responds to cholesterol as its substrate in a sigmoidal manner, kinetic analysis
-
additional information
additional information
-
for the various Cys-deficient mutant ACAT1s, the Km value for oleoyl-coenzyme A is approximately 2fold higher than the value for the wild-type enzyme, ranging between 0.012 und 0.015 mM
-
additional information
additional information
ACAT2 is an allosteric enzyme, modeling, overview. The enzyme responds to cholesterol as its substrate in a sigmoidal manner, kinetic analysis
-
additional information
additional information
ACAT2 is an allosteric enzyme, modeling, overview. The enzyme responds to cholesterol as its substrate in a sigmoidal manner, kinetic analysis
-
additional information
additional information
-
ACAT2 is an allosteric enzyme, modeling, overview. The enzyme responds to cholesterol as its substrate in a sigmoidal manner, kinetic analysis
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.000378
2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide
-
inhibition is competitive with respect to oleoyl-coenzyme A
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.071
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-2-(2-methoxyphenyl)-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00178
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-chlorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00079
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0027
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-fluorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0034
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-methoxybenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0043
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-bromobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0027
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-chlorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0022
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.003
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-fluorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0043
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-methoxybenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0069
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-bromobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0058
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-chlorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0028
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0062
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0055
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-formylbenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0069
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-methoxybenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0139
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-nitrobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0728
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0139
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00373
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00951
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00811
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00554
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0691
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(naphthalen-2-yl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.01
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,4-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0712
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,6-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00033
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2-fluorophenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00276
(3S,4aR,6S,6aS,12R,12aS,12bS)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-(propanoyloxy)-4-[(propanoyloxy)methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0049
(3S,4aR,6S,6aS,12R,12aS,12bS)-12-hydroxy-4,6a,12b-trimethyl-3-[(2-methylpropanoyl)oxy]-4-[[(2-methylpropanoyl)oxy]methyl]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00364
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-(propylcarbamoyl)-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00666
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-[(propanoyloxy)methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00092
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-[[(3-phenylpropanoyl)oxy]methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00915
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-4-[[(2-methylpropanoyl)oxy]methyl]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.014
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4-[(2-methoxy-2-oxoethyl)carbamoyl]-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0138
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(2-ethoxy-2-oxoethyl)carbamoyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00143
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2,3,4-trifluorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.001
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-chlorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00162
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.001
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-fluorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00019
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-iodobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00269
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-methoxybenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00042
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-methylbenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00011
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-(methylsulfanyl)benzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00012
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-bromobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00021
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-chlorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00223
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00015
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-ethenylbenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00096
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-methoxybenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00043
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-methylbenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00414
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-nitrobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00023
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00025
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-iodobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00015
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-methoxybenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00065
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-methylbenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00066
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(2lambda~5~-triaza-1,2-dien-2-yl)benzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00054
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(methylsulfanyl)benzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0051
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-aminobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00115
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromo-2-fluorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00049
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromo-3-fluorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00083
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00089
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-chloro-2-iodobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00069
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-chlorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00065
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyano-3-fluorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00416
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.00071
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-ethenylbenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00019
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-ethylbenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00079
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-fluorobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0028
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-hydroxybenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00117
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-iodobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00051
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-methoxybenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00741
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-nitrobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.1263
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[[(2,4-dimethoxyphenyl)methyl]carbamoyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0152
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-6-[(4-cyanobenzoyl)oxy]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-carboxylic acid
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.063
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(benzoyloxy)-4-[(benzoyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0639
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(hexanoyloxy)-4-[(hexanoyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00206
(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-(propanoyloxy)-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00039
(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-[(phenylacetyl)oxy]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00199
(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-3-[(2-methylpropanoyl)oxy]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0136
(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl 2-methylpropanoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00286
(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl 3-phenylpropanoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0273
(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl propanoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00046
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2,2-difluoro-2H-1,3-benzodioxole-5-carboxylate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0038
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(1-benzothiophen-2-yl)benzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00027
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-methylbenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00071
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 5,8-dihydronaphthalene-2-carboxylate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00068
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl benzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0032
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl naphthalene-1-carboxylate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0007
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl [1,1'-biphenyl]-4-carboxylate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0281
2-[(2E,6Z,8E,10E)-dodeca-2,6,8,10-tetraenoylamino]-1,1-dimethylethyl acetate
Homo sapiens
IC50: 0.0281 mM
0.017
5-(1-butoxy-2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}propyl)-1,3-benzodioxole
Homo sapiens
IC50: 0.017 mM
0.031
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-ethoxypropyl)-1,3-benzodioxole
Homo sapiens
IC50: 0.031 mM
0.035
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-methoxypropyl)-1,3-benzodioxole
Homo sapiens
IC50: 0.035 mM
0.014
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-propoxypropyl)-1,3-benzodioxole
Homo sapiens
IC50: 0.014 mM
0.05
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(heptyloxy)propyl]-1,3-benzodioxole
Homo sapiens
IC50: 0.05 mM
0.034
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(hexyloxy)propyl]-1,3-benzodioxole
Homo sapiens
IC50: 0.034 mM
0.02
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(pentyloxy)propyl]-1,3-benzodioxole
Homo sapiens
IC50: 0.02 mM
0.012
celludinone A1
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.015
celludinone A2
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.0029
celludinone B
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.0052
FD-549
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.0148
methyl (3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-6-[(4-cyanobenzoyl)oxy]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-carboxylate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.08
pyripyropene A
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.028
[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl 2-methylpropanoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0043
[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl 3-phenylpropanoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.052
[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl propanoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0138 - 0.0251
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 3-methylbutanoate
0.0537 - 0.0562
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl benzoate
0.0496 - 0.0776
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl butanoate
0.0307 - 0.0714
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pent-4-enoate
0.0845 - 0.0948
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pentanoate
0.0224 - 0.0287
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl propanoate
0.0000368
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-2-(2-methoxyphenyl)-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00011
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-chlorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00032
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00005
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-fluorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00032
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-methoxybenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00003
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-bromobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000019
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-chlorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00003
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000013
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-fluorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00007
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-methoxybenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00001
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-bromobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000009
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-chlorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000006
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000007
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00003
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-formylbenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000014
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-methoxybenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00006
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-nitrobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000118
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000023
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000078
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000476
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000097
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000151
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000232
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(naphthalen-2-yl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000066
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,4-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000072
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,6-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000068
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2-fluorophenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000077
(2S)-2-[(5aR,6R,8R,9aR,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]propane-1,2-diyl diacetate
Homo sapiens
NBD22-steryl ester fluorescence assay, pH not specified in the publication, temperature not specified in the publication
0.0000056
(3S,4aR,6S,6aS,12R,12aS,12bS)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-(propanoyloxy)-4-[(propanoyloxy)methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000065
(3S,4aR,6S,6aS,12R,12aS,12bS)-12-hydroxy-4,6a,12b-trimethyl-3-[(2-methylpropanoyl)oxy]-4-[[(2-methylpropanoyl)oxy]methyl]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00101
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-(propylcarbamoyl)-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000144
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-[(propanoyloxy)methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000619
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-[[(3-phenylpropanoyl)oxy]methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000042
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-4-[[(2-methylpropanoyl)oxy]methyl]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00341
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4-[(2-methoxy-2-oxoethyl)carbamoyl]-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00309
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(2-ethoxy-2-oxoethyl)carbamoyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000081
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2,3,4-trifluorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00006
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-chlorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00029
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00003
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-fluorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000005
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-iodobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00023
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-methoxybenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00001
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-methylbenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000009
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-(methylsulfanyl)benzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000012
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-bromobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000007
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-chlorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00001
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000011
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-ethenylbenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000061
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-methoxybenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000063
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-methylbenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000006
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-nitrobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000009
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000005
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-iodobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000015
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-methoxybenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000005
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-methylbenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000005
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(2lambda~5~-triaza-1,2-dien-2-yl)benzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000027
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(methylsulfanyl)benzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0002
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-aminobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000007
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromo-2-fluorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000005
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromo-3-fluorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000002
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000039
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-chloro-2-iodobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000001
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-chlorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000078
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyano-3-fluorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000009
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.000005
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-ethenylbenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000001
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-ethylbenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000017
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-fluorobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00027
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-hydroxybenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000004
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-iodobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000008
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-methoxybenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000005
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-nitrobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00014
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[[(2,4-dimethoxyphenyl)methyl]carbamoyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0152
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-6-[(4-cyanobenzoyl)oxy]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-carboxylic acid
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00076
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(benzoyloxy)-4-[(benzoyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00067
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(hexanoyloxy)-4-[(hexanoyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00001
(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-(propanoyloxy)-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000096
(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-[(phenylacetyl)oxy]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000015
(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-3-[(2-methylpropanoyl)oxy]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00122
(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl 2-methylpropanoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0005
(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl 3-phenylpropanoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000897
(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl propanoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00002
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2,2-difluoro-2H-1,3-benzodioxole-5-carboxylate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00004
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(1-benzothiophen-2-yl)benzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000009
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-methylbenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000019
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 5,8-dihydronaphthalene-2-carboxylate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00001
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl benzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00027
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl naphthalene-1-carboxylate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000095
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl [1,1'-biphenyl]-4-carboxylate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0875
2-[(2E,6Z,8E,10E)-dodeca-2,6,8,10-tetraenoylamino]-1,1-dimethylethyl acetate
Homo sapiens
IC50: 0.0875 mM
0.000077 - 0.0017
2-[(5aR,6R,8R,9aR,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
0.000416 - 0.002456
2-[(5aR,6R,8R,9aR,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
0.000155
2-[(5aS,6S,8S,9aS)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
Homo sapiens
-
isozyme ACAT2, pH and temperature not specified in the publication
0.001789 - 0.003059
2-[(5aS,6S,8S,9aS,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
0.000743 - 0.001272
2-[(5aS,6S,8S,9aS,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
0.000068 - 0.1028
2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide
0.008
celludinone A1
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.013
celludinone A2
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.000069
celludinone B
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.00068
FD-549
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.00065
methyl (3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-6-[(4-cyanobenzoyl)oxy]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-carboxylate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000075
[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl 2-methylpropanoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00089
[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl 3-phenylpropanoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000772
[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl propanoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.00416
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.00416
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT1, pH and temperature not specified in the publication
0.0018
biseokeaniamide A
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.0018
biseokeaniamide A
Homo sapiens
enzyme-based assay, 37°C, pH not specified in the publication
0.0068
biseokeaniamide B
Homo sapiens
enzyme-based assay, 37°C, pH not specified in the publication
0.0069
biseokeaniamide B
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.011
biseokeaniamide C
Homo sapiens
enzyme-based assay, 37°C, pH not specified in the publication
0.012
biseokeaniamide C
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.0009
purpactin A
Homo sapiens
enzyme-based assay, 37°C, pH not specified in the publication
0.0025
purpactin A
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.0138
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 3-methylbutanoate
Homo sapiens
-
-
0.0251
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 3-methylbutanoate
Homo sapiens
-
-
0.0537
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl benzoate
Homo sapiens
-
-
0.0562
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl benzoate
Homo sapiens
-
-
0.0496
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl butanoate
Homo sapiens
-
-
0.0776
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl butanoate
Homo sapiens
-
-
0.0307
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pent-4-enoate
Homo sapiens
-
-
0.0714
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pent-4-enoate
Homo sapiens
-
-
0.0845
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pentanoate
Homo sapiens
-
-
0.0948
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pentanoate
Homo sapiens
-
-
0.0224
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl propanoate
Homo sapiens
-
-
0.0287
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl propanoate
Homo sapiens
-
-
0.0000009
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.0000009
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000077
2-[(5aR,6R,8R,9aR,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
Homo sapiens
-
isozyme ACAT2, pH and temperature not specified in the publication
0.0017
2-[(5aR,6R,8R,9aR,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
Homo sapiens
-
isozyme ACAT2, pH and temperature not specified in the publication
0.000416
2-[(5aR,6R,8R,9aR,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
Homo sapiens
-
isozyme ACAT2, pH and temperature not specified in the publication
0.002456
2-[(5aR,6R,8R,9aR,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
Homo sapiens
-
isozyme ACAT2, pH and temperature not specified in the publication
0.001789
2-[(5aS,6S,8S,9aS,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
Homo sapiens
-
isozyme ACAT2, pH and temperature not specified in the publication
0.003059
2-[(5aS,6S,8S,9aS,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
Homo sapiens
-
isozyme ACAT2, pH and temperature not specified in the publication
0.000743
2-[(5aS,6S,8S,9aS,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
Homo sapiens
-
isozyme ACAT2, pH and temperature not specified in the publication
0.001272
2-[(5aS,6S,8S,9aS,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
Homo sapiens
-
isozyme ACAT2, pH and temperature not specified in the publication
0.000068
2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide
Homo sapiens
-
inhibition of cholesterol esterification in human monocyte-derived macrophages
0.00045
2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide
Homo sapiens
-
recombinant ACAT-1, K-604 is 229-fold more selective for ACAT-1 than for ACAT-2
0.1028
2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide
Homo sapiens
-
recombinant ACAT-2
0.0013
biseokeaniamide A
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.0096
biseokeaniamide A
Homo sapiens
enzyme-based assay, 37°C, pH not specified in the publication
0.0025
biseokeaniamide B
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.0099
biseokeaniamide B
Homo sapiens
enzyme-based assay, 37°C, pH not specified in the publication
0.032
biseokeaniamide C
Homo sapiens
enzyme-based assay, 37°C, pH not specified in the publication
0.096
biseokeaniamide C
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.000918
purpactin A
Homo sapiens
enzyme-based assay, 37°C, pH not specified in the publication
0.0015
purpactin A
Homo sapiens
cell-based assay, 37°C, pH not specified in the publication
0.00007
pyripyropene A
Homo sapiens
isozyme ACAT2, pH and temperature not specified in the publication
0.000185
pyripyropene A
Homo sapiens
-
isozyme ACAT2, pH and temperature not specified in the publication
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.0000293
-
ACAT2 activity, effect on ChSI on hepatic ACAT2 expression, high cholesterol synthesis inhibition, high ChSI
0.0000333
-
ACAT2 activity, effect on ChSI on hepatic ACAT2 expression, low cholesterol synthesis inhibition, low ChSI
0.0000377
-
ACAT2 activity, effect on cholesterol synthesis inhibition on hepatic ACAT2 expression, placebo
0.00562
additional information
additional information
-
when yeast-expressed enzyme activity is measured in the presence of ergosterol liposomes, specific activity is reduced more than 80%, recombinant enzyme is active but unable to esterify ergosterol efficiently
additional information
-
activation of the enzyme by adding 25-hydroxycholesterol to intact cells or to cell-free extracts
additional information
-
comparison of enzyme activities of cells grown in fetal calf serum medium and in delipidated serum medium
additional information
-
the enzyme activity of a stable clone of H293 cells expressing HisACAT1/Flag is about 9-10times higher than that of a stable clone of CHO cells either expressing hACAT1 or expressing HisACAT1
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.4
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
37
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
isozyme ACAT1 is the major isozyme in human primary hepatic stellate cells, little isozyme ACAT2 expression in the cells
serotonin upregiulates ACAT-1 expression in human monocyte-macrophages
high percentage (seven of fourteen) of liver samples from patients affected with hepatocellular carcinoma exhibit elevated ACAT2 expression
additional information
the CDX2 (caudal type homeobox transcription factor 2) expression is elevated, accounting for its elevated ACAT2 expression
in normal adult human liver, CDX2 (caudal type homeobox transcription factor 2) expression is not detectable and the ACAT2 expression is very low
additional information
ACAT1 is ubiquitously expressed in essentially all tissues examined
additional information
ACAT1 is ubiquitously expressed in essentially all tissues examined
additional information
-
ACAT1 is ubiquitously expressed in essentially all tissues examined
additional information
ACAT2 is mainly expressed in the intestines and hepatocytes. It is also expressed in various other tissues, but at much lower levels than ACAT1
additional information
ACAT2 is mainly expressed in the intestines and hepatocytes. It is also expressed in various other tissues, but at much lower levels than ACAT1
additional information
-
ACAT2 is mainly expressed in the intestines and hepatocytes. It is also expressed in various other tissues, but at much lower levels than ACAT1
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
additional information
ACAT1 is a resident enzyme at the endoplasmic reticulum
additional information
ACAT1 is in a position to esterify cholesterol and various cholesterol metabolites (i.e., oxysterols, pregnenolone etc.) traversing through the mitochondria and endoplasmic reticulum membranes
-
additional information
ACAT1 is in a position to esterify cholesterol and various cholesterol metabolites (i.e., oxysterols, pregnenolone etc.) traversing through the mitochondria and endoplasmic reticulum membranes
-
additional information
-
ACAT1 is in a position to esterify cholesterol and various cholesterol metabolites (i.e., oxysterols, pregnenolone etc.) traversing through the mitochondria and endoplasmic reticulum membranes
-
additional information
-
cholesterol flux into and out of the endoplasmic reticulum
-
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
along with acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), ACAT1 and ACAT2 are founding members of the membrane-bound O-acyltransferase (MBOAT) enzyme family. MBOATs are multispan membrane enzymes that use long-chain or medium-chain fatty acyl-CoA as the first substrate, and catalyze the transfer of the fatty acyl group to the 3beta-hydroxyl moiety of a certain hydrophobic substance as the second substrate. An MBOAT contains two active sites: a histidine within a long hydrophobic peptide region, and an asparagine located within a long hydrophilic peptide region
malfunction
metabolism
the enzyme converts cholesterol to cholesteryl esters and plays key roles in the regulation of cellular cholesterol homeostasis. It metabolizes diverse substrates including both sterols and certain steroids, and it contains two different binding sites for steroidal molecules
physiological function
evolution
along with acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), ACAT1 and ACAT2 are founding members of the membrane-bound O-acyltransferase (MBOAT) enzyme family. MBOATs are multispan membrane enzymes that use long-chain or medium-chain fatty acyl-CoA as the first substrate, and catalyze the transfer of the fatty acyl group to the 3beta-hydroxyl moiety of a certain hydrophobic substance as the second substrate. An MBOAT contains two active sites: a histidine within a long hydrophobic peptide region, and an asparagine located within a long hydrophilic peptide region
malfunction
mice lacking ACAT1 or ACAT2 do not have a decreased pregnenolone ester contents in adrenals, nor do they have altered levels of the three major secreted adrenal steroids in serum
metabolism
the enzyme converts cholesterol to cholesteryl esters and plays key roles in the regulation of cellular cholesterol homeostasis. It metabolizes diverse substrates including both sterols and certain steroids, and it contains two different binding sites for steroidal molecules
physiological function
additional information
malfunction
mice lacking ACAT1 or ACAT2 do not have a decreased PREG ester contents in adrenals, nor do they have altered levels of the three major secreted adrenal steroids in serum
malfunction
ACAT1 deficiency significantly increases free cholesterol levels in hepatic stellate cells, augmenting Toll-like receptor 4, TLR4, protein and downregulating expression of transforming growth factor-beta (TGFbeta) pseudoreceptor Bambi (bone morphogenetic protein and activin membrane-bound inhibitor), leading to sensitization of hepatic stellate cells to TGFbeta activation. Exacerbation of liver fibrosis by ACAT1 deficiency is dependent on free cholesterol accumulation-induced enhancement of TLR4 signaling. ACAT1 deficiency does not affect hepatic ACAT2 expression, effects of ACAT1 deficiency on induced liver fibrosis, overview
malfunction
blocking ACAT enzyme activity with ACAT inhibitors, or with genetic ablation of ACAT1, significantly increases macrophage apoptosis
physiological function
a major function of ACATs is to protect against the unnecessary built up of free cholesterol within the cell membranes. ACAT1 may be involved in negatively regulating steroidogenesis in human adrenal cells. Both ACAT1 and ACAT2 can control the oxysterol levels by directly esterifying them, in a cell-type specific manner. ACAT can also control oxysterol levels by altering the cholesterol pool from which oxysterols are derived
physiological function
acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells, role of ACAT1 in the pathogenesis of liver fibrosis, overview
physiological function
a major function of ACATs is to protect against the unnecessary built up of free cholesterol within the cell membranes. In intestines, ACAT2 provides cholesteryl esters for lipoprotein assemblies. Both ACAT1 and ACAT2 can control the oxysterol levels by directly esterifying them, in a cell-type specific manner. ACAT can also control oxysterol levels by altering the cholesterol pool from which oxysterols are derived
physiological function
-
isozyme ACAT2 is responsible for absorption of dietary cholesterol from the intestine and lipoprotein production by the liver, the steryl esters catalyzed by ACAT2 can incorporate into both intracellular lipid droplets and extracellular lipoproteins
physiological function
the enzyme plays a critical role in the formation of cholesteryl esters from cholesterol and fatty acids
additional information
two human ACAT2 gene polymorphisms have significant effects on 41A-G (Glu14Gly, rs9658625) and 734C-T (Thr254Ile, rs2272296), on plasma lipid levels and coronary artery disease susceptibility
additional information
-
two human ACAT2 gene polymorphisms have significant effects on 41A-G (Glu14Gly, rs9658625) and 734C-T (Thr254Ile, rs2272296), on plasma lipid levels and coronary artery disease susceptibility
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). SOAT1_HUMAN
550
8
64735
Swiss-Prot
other Location (Reliability: 2)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
200000 - 250000
sucrose density gradient centrifugation, protein solubilized by CHAPS
50000
4 * 50000, enzyme protein transcribed from exons 1-16, SDS-PAGE, 4 * 56000, second enzyme variant from chromosome 7, SDS-PAGE, ACAT1 may act as a dimer of dimer
56000
4 * 50000, enzyme protein transcribed from exons 1-16, SDS-PAGE, 4 * 56000, second enzyme variant from chromosome 7, SDS-PAGE, ACAT1 may act as a dimer of dimer
80000 - 150000
sucrose density gradient centrifugation, protein solubilized by Triton X-100 or octylglucoside
50000
additional information
additional information
method to quantify and map the disulfide linkage. Cys92 is located on the cytoplasmic side of the endoplasmic reticulum membrane and the disulfide is located in the ER lumen, while all other free Cys are located within the hydrophobic regions of the enzyme
additional information
-
method to quantify and map the disulfide linkage. Cys92 is located on the cytoplasmic side of the endoplasmic reticulum membrane and the disulfide is located in the ER lumen, while all other free Cys are located within the hydrophobic regions of the enzyme
additional information
-
expected monomer molecular masses of different fusion proteins range between 33000 and 41000 Da, sucrose density gradient velocity ultracentrifugation shows molecular masses of different fusion proteins ranging from 70000 to 160000 Da, thus some fusion proteins behave as tetramers in solution and other behave as dimers in solution
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
tetramer
homotetramer
additional information
tetramer
4 * 50000, enzyme protein transcribed from exons 1-16, SDS-PAGE, 4 * 56000, second enzyme variant from chromosome 7, SDS-PAGE, ACAT1 may act as a dimer of dimer
homotetramer
-
use of chemical cross-linking agent disuccinimidyl suberate causes the formation of material two to four times the size of the monomeric enzyme when added to intact cells expressing either wild-type ACAT1 or mutant ACAT1 C92/333/345/365/387/467/516/528/546A
additional information
ACAT1 contains two dimerization motifs. The first motif is located near the N-terminus and is not conserved. Deletion of the N-terminal dimerization domain converts ACAT1 to a dimer with full catalytic activity, i.e. ACAT1 is a two-fold dimer. The second dimerization domain, located near the C-terminus, is conserved
additional information
-
SDS-PAGE: detection of two protein bands with apparent sizes at 50 and 56 kDa, immunoblots: existence of 100 and 200 kDa bands, clarification of these observations needed
additional information
-
deleting a dimer-forming motif from the full-length ACAT1 converts the enzyme from a homotetramer to a homodimer that is more catalytically active than the native homotetramer
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
H386A
complete loss of activity. Enzymatic activity is restored to values below 37% of the level of the wild-type activity when cholesterol is replaced by 25-hydroxycholesterol as substrate
H425A
59% of the wild-type activity, inhibitory sensitivity against oleic acid anilide ias decreased about 3fold
H527A
96% of the wild-type activity, inhibitory sensitivity against oleic acid anilide ias decreased about 10fold
C333A
-
expressed in H5 cells, the mutant retains a significant amount of activity, Cys-333 is not essential for ACAT1 catalysis, the mutant is expressed as a single, undegraded 50-kDA band
C333A/C345A/C365A
-
expressed in H5 cells, the mutant contains essentially the same activity as the wild-type ACAT1. Sensitive to p-chloromercuribenzene sulfonic acid inhibition
C345A
-
expressed in H5 cells, the mutant retains a significant amount of activity, Cys-345 is not essential for ACAT1 catalysis, the mutant is expressed as a single, undegraded 50-kDA band
C365A
-
expressed in H5 cells, the mutant retains a significant amount of activity, Cys-365 is not essential for ACAT1 catalysis, the mutant is expressed as a single, undegraded 50-kDA band
C387A
-
expressed in H5 cells, the mutant retains a significant amount of activity, Cys-387 is not essential for ACAT1 catalysis, the mutant is expressed as a single, undegraded 50-kDA band
C467A
-
expressed in H5 cells, the mutant retains a significant amount of activity, Cys-467 is not essential for ACAT1 catalysis, the mutant is expressed as a single, undegraded 50-kDA band
C516A
-
expressed in H5 cells, the mutant retains a significant amount of activity, Cys-516 is not essential for ACAT1 catalysis, the mutant is expressed as a single, undegraded 50-kDA band
C528A
-
expressed in H5 cells, the mutant retains a significant amount of activity, Cys-528 is not essential for ACAT1 catalysis, the mutant is expressed as a single, undegraded 50-kDA band
C546A
-
expressed in H5 cells, the mutant retains a significant amount of activity , Cys-546 is not essential for ACAT1 catalysis, the mutant is expressed as a single, undegraded 50-kDA band
C92A
-
expressed in H5 cells, the mutant retains a significant amount of activity, Cys-92 is not essential for ACAT1 catalysis, the mutant is expressed as a single, undegraded 50-kDA band
C92A/C333A/C345A/C365A/C387A/C467A/C516A
-
resistant to p-chloromercuribenzene sulfonic acid inhibition
C92A/C333A/C345A/C365A/C387A/C467A/C516A/C528A/C54
C92A/C333A/C345A/C365A/C387A/C467A/C516A/C546A
C92A/C333A/C345A/C365A/C387A/C516A/C528A/C546A
-
sensitive to p-chloromercuribenzene sulfonic acid inhibition
C92A/C333A/C345A/C365A/C467A/C516A/C546A
-
expressed in H5 cells or in ACAT-deficient Chinese hamster ovary cells: both mutants retain partial enzyme activity. Resistant to p-chloromercuribenzene sulfonic acid inhibition
C92A/C333A/C365A/C387A/C467A/C516A/C528A/C546A
-
insensitive to p-chloromercuribenzene sulfonic acid
C92A/C467A/C516A/C546A
E14G
naturally occuring polymorphism, the enzymatic activity of the mutant is approximately two times higher than the wild-type activity
H501A
75% of the wild-type activity, inhibitory sensitivity against oleic acid anilide ias decreased about 10fold
T254I
naturally occuring polymorphism, the mutant shows enzyme the same enzyme activity as the wild-type
additional information
C92A/C333A/C345A/C365A/C387A/C467A/C516A/C528A/C54
-
expressed in H5 cells or in ACAT-deficient Chinese hamster ovary cells: both mutants retain partial enzyme activity
C92A/C333A/C345A/C365A/C387A/C467A/C516A/C528A/C54
-
this mutant is localized in endoplasmic reticulum in Chinese hamster ovary cells, homotetramer. Insensitive to p-chloromercuribenzene sulfonic acid
C92A/C333A/C345A/C365A/C387A/C467A/C516A/C546A
-
this mutant is localized in endoplasmic reticulum in Chinese hamster ovary cells
C92A/C333A/C345A/C365A/C387A/C467A/C516A/C546A
-
expressed in H5 cells or in ACAT-deficient Chinese hamster ovary cells: both mutants retain partial enzyme activity. Resistant to p-chloromercuribenzene sulfonic acid inhibition
C92A/C467A/C516A/C546A
-
expressed in H5 cells or in ACAT-deficient Chinese hamster ovary cells: both mutants retain partial enzyme activity
C92A/C467A/C516A/C546A
-
this mutant is localized in endoplasmic reticulum in Chinese hamster ovary cells
additional information
-
production of double or single proline mutants derived from glutathione S-transferase-ACAT1 fusion proteins shows that the dimer-forming domain is within ACAT1 amino acids 30 to 94. Production of mutants derived from the recombinant plasmid pHisACAT1 to test the effect of mutagenizing or deleting the N-terminal peptide on the oligomerization state of ACAT1
additional information
-
insertion of two different antigenic tags at various hydrophilic regions flanking each of the predicted transmembrane domains, analysis indicates that the enzyme contains only 2 detectable transmembrane domains, located near the N-terminal region
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
50
-
apparent t1/2 of activity loss: approximately 12 min for HisACAT1 and 20 min for the mutant HisACAT1/1-65, for the mutant HisACAT1/P64 the heat inactivation curve falls between the curves for HisACAT1 and HisACAT/1-65 and its shape seems to be biphasic
additional information
additional information
the enzyme activity in Chinese hamster cells is more thermolabile than the enzyme activity in human cells
additional information
-
the enzyme activity in Chinese hamster cells is more thermolabile than the enzyme activity in human cells
additional information
-
enzyme activity expressed in Sf9 insect cells exhibits heat stability comparable of that of human enzyme, its heat stability is significantly greater than that of hamster enzyme
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant 50-kDa human ACAT1 to homogeneity with full retention in enzymatic activity
when solubilized in the detergent CHAPS, ACAT1 can be purified to homogeneity with full enzyme activity and behaves as a homotetrameric protein. Treating ACAT1 with non-ionic detergent, Triton X-100 or octyl glucoside, leads to a two-fold monomer without any enzymatic activity. Detergent exchange of Triton X-100 with CHAPS restores ACAT1 to a two-fold dimer but fails to restore its enzymatic activity
microsomal fractions of Hi5 cells containing baculovirally expressed hACAT-1 are prepared and used as the source for the enzyme
microsomal fractions of Hi5 cells containing baculovirally expressed hACAT-1 are used as sources of the enzyme
-
microsomal fractions of Hi5 cells containing baculovirally expressed hACAT-2 are prepared and used as the source for the enzyme
microsomal fractions of Hi5 cells containing baculovirally expressed hACAT-2 are used as sources of the enzyme
-
microsomes prepared from monocyte-derived macrophagesare are used as an enzyme source
-
of the glutathione S-transferase-ACAT1 peptide fusion protein using chromatography on glutathione-Sepharose 4B column and of various recombinant HisACAT1s expressed in infected H5 cells using a Talon Superflow resin
-
of the recombinant enzyme using solubilization with CHAPS und KCl, chromatography on cobalt column and chromatography on monoclonal antibody affinity column
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene ACAT1, human Acat1 is located in two different chromosomes, chromosomes 1 and 7, with each site containing a distinct promoter: chromosome 1 contains exons 1-16, and chromosome 7 contains the optional long exon Xa, recombinant expression, functional complementation of a Chinese hamster ovary cell mutant lacking ACAT activity, the majority of ACAT1 mRNAs is transcribed from exons 1-16
a recombinant baculovirus transfer vector is constructed by subcloning of human ACAT-1 cDNA into pFASTBacHis
-
a recombinant baculovirus transfer vector is constructed by subcloning of human ACAT-2 cDNA into pFASTBacHis
-
gene ACAT2, genotying, sequence comparison and phylogenetic analysis, two human ACAT2 gene polymorphisms have significant effects on 41A-G (Glu14Gly, rs9658625) and 734C-T (Thr254Ile, rs2272296), on plasma lipid levels and coronary artery disease susceptibility, recombinant expression of wild-tpe and mutant enzymes in ACAT-deficient AC-29 cells
production of glutathione S-transferase-ACAT1 fusion proteins, expression of fusion proteins in Escherichia coli and expression of various recombinant HisACAT1s in infected H5 cells
-
sequence analysis and human cDNA clones indicate homology to liver carboxylesterase
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
ACAT2 expression is induced upon androgen agonist R1881 treatment of LNCaP cells. Increase in the in vitro ACAT1 activity in PC-3 cells treated with androgen
-
angiotensin II significantly increases ACAT1 protein expression in a time- or concentration-dependent manner. Application of angiotensin II type 1 receptor agonist L162313, but not angiotensin II type 2 receptor agonist CGP42112A, mimicks the effects of angiotensin II treatment in inducing ACAT1 protein expression. ACAT activity and ACAT1 mRNA levels are also significantly increased by angiotensin II. Two-fold increases in ACAT1 protein expression and ACAT activity with angiotensin II treatment are completely inhibited by angiotensin type I receptor antagonists candesartan, [Sar(1),Ile(8)]-angiotensin II
-
extracellular signal-regulated kinase inhibitor PD98059, p38 mitogen-activated protein kinase inhibitor SB203580, or c-Jun N-terminal kinase inhibitor SP600125 down-regulate the expression of ACAT1 in a dose-dependent manner
-
in PC-3 cells treated with androgen agonist R1881, ACAT1 protein expression and cholesterol ester levels are decreased
-
no effect from androgen treatment on ACAT1 protein expression in LNCaP cells nor from treatment on ACAT2 expression in PC-3 cells
-
RENATURED/Commentary
ORGANISM
UNIPROT
LITERATURE
solubilization of the cell extracts with deoxycholate followed by dilution into preformed liposomes
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
drug development
regulation of ACAT1 activities in hepatic stellate cells can be a target for treatment of liver fibrosis
medicine
drug development
medicine
pharmacology
medicine
a panel of ovarian cancer cell lines (OC-314, SKOV-3 and IGROV-1) displays significant increase in the expression of ACAT1 and cholesterol ester levels compared to primary ovarian epithelial cells. ACAT1 knockdown ovarian cancer cell lines show significant suppression of cell proliferation, migration and invasion compared to their respective controls. ACAT-1 inhibition enhances apoptosis with a concurrent increase in caspases 3/7 activity and decreased mitochondrial membrane potential, and ACAT1-inhibited ovarian cancer cell lines display enhanced chemosensitivity to cisplatin treatment
medicine
treatment of 63 patients with metastatic adrenocortical carcinoma with oral nevanimibe at doses ranging from 1.6 mg/kg/day to 158.5 mg/kg/day. No patients experienced a complete or partial response. 13 of 48 (27%) patients who underwent imaging at 2 months had stable disease, and 4 of these had stable disease for more than 4 months
drug development
the enzyme is a potential target for treating hypercholesterolemia
drug development
-
the enzyme is regarded as a potential therapeutic target for cardiovascular diseases
medicine
-
identified as a major target for inhibition, based on the hypothesis that enzyme inhibitors may have a direct antiatherosclerotic effect within the arterial wall and a direct effect in blocking cholesterol absorption in the small intestine, and in reducing very-low-density lipoprotein secretion in the hepatocytes
medicine
-
for both isoform ACTA1 and ACAT2, overexpression in rat hepatoma McA-RH7777 cells results in increased synthesis, cellular accumulation, and secretion of cholesteryl esters. This leads to decreased intracellular degradation and increased secretion of very low density liporotein apoB. Overexpression of ACAT2 has significantly greater impact upon assembly and secretion of very low density liporotein from liver cells than that of ACAT1
medicine
elevated ACAT2expression may serve as a new biomarker for certain forms of hepatocellular carcinoma
medicine
-
systemic ACAT inhibition reduces circulating tumor necrosis factor-alpha levels in hypercholesterolemic subjects and improves resistance-vessel endothelial function, with small effects on circulating cholesterol. This may be a novel therapeutic strategy to target vascular inflammation and endothelial dysfunction in atherosclerosis
medicine
-
an anti-oxidative ACAT inhibitor or the combination of an antioxidant and an ACAT inhibitor protects foam cells from oxidative stress and effectively reduces cholesterol levels, which would be a promising approach in anti-atherosclerotic therapy
medicine
-
statin treatment reduces ACAT2 activity in human liver and this effect, in combination with a reduced ApoE expression, may contribute to the favorable lowering of VLDL cholesterol seen in addition to the LDL lowering during statin treatment
medicine
-
the study provides evidence that purified esculeogenin A significantly suppresses the activity of ACAT protein and leads to reduction of atherogenesis
pharmacology
-
ACAT-1 and ACAT-2 selective inhibitors may prove to have clinical benefit to reduce atherosclerosis via directly reducing the size of the lipid-rich core in the atherosclerotic plaques or the absorption of cholesterol in intestine, respectively
pharmacology
-
K-604, a potent and selective inhibitor of ACAT-1, suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels, providing direct evidence that pharmacological inhibition of ACAT-1 in the arterial walls leads to suppression of atherosclerosis
pharmacology
-
the data suggest that antiatherosclerotic activity of licorice in hypercholesterolemic patients might be related with its ACAT inhibitory effects
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Billheimer, J.T.
Cholesterol acyltransferase
Methods Enzymol.
111
286-293
1985
Saccharomyces cerevisiae, Helicoverpa zea, Homo sapiens, Rattus norvegicus, Sus scrofa
Chang, T.Y.; Doolittle, G.M.
Acyl coenzyme A:cholesterol O-acyltransferase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
16
523-539
1983
Cavia porcellus, Cricetulus griseus, Columba sp., Oryctolagus cuniculus, Homo sapiens, Platyrrhini, Mus musculus, Rattus norvegicus, Sus scrofa
-
Simpson, E.R.; Burkhart, M.F.
Acyl CoA:cholesterol acyl transferase activity in human placental microsomes: inhibition by progesterone
Arch. Biochem. Biophys.
200
79-85
1980
Homo sapiens
Helgerud, P.; Saarem, K.; Norum, K.R.
Acyl-CoA:cholesterol acyltransferase in human small intestine: its activity and some properties of the enzymic reaction
J. Lipid Res.
22
271-277
1981
Homo sapiens
Einarsson, K.; Benthin, L.; Ewerth, S.; Heller, G.; Staehlberg, D.; Angelin, B.
Studies on acyl-coenzyme A:cholesterol acyltransferase activity in human liver microsomes
J. Lipid Res.
30
739-746
1989
Homo sapiens
Cadigan, K.M.; Chang, T.Y.
A simple method for reconstitution of CHO cell and human fibroblast acyl coenzyme A:cholesterol acyltransferase activity into liposomes
J. Lipid Res.
29
1683-1692
1988
Cricetulus griseus, Homo sapiens
Chang, C.C.Y.; Huh, J.Y.; Cadigan, K.M.; Chang, T.Y.
Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells
J. Biol. Chem.
268
20747-20755
1993
Homo sapiens (P35610), Homo sapiens
Becker, A.; Bttcher, A.; Lackner, K.J.; Fehringer, P.; Notka, F.; Aslanidis, C.; Schmitz, G.
Purification, cloning, and expression of a human enzyme with acyl coenzyme A:cholesterol acyltransferase activity, which is identical to liver carboxylesterase
Arterioscler. Thromb.
14
1346-1355
1994
Homo sapiens, Sus scrofa
Cheng, D.; Chang C.C.Y.; Qu, X.; Chang, T.
Activation of acyl-coenzyme A:cholesterol acyltransferase by cholesterol or by oxysterol in a cell-free system
J. Biol. Chem.
270
685-695
1995
Homo sapiens
Yu, C.; Kennedy, N.J.; Chang, C.C.Y.; Rothblatt, J.A.
Molecular cloning and characterization of two isoforms of Saccharomyces cerevisiae acyl-CoA:sterol acyltransferase
J. Biol. Chem.
271
24157-24163
1996
Homo sapiens, Saccharomyces cerevisiae (P53629), Saccharomyces cerevisiae
Kerkhoff, C.; Beuck, M.; Threige-Rasmussen, J.; Spener, F.; Knudsen, J.; Schmitz, G.
Acyl-CoA binding protein (ACBP) regulates acyl-CoA:cholesterol acyltransferase (ACAT) in human mononuclear phagocytes
Biochim. Biophys. Acta
1346
163-172
1997
Homo sapiens
Chang, T.Y.; Chang, C.C.Y.; Cheng, D.
Acyl-coenzyme A:cholesterol acyltransferase
Annu. Rev. Biochem.
66
613-638
1997
Cavia porcellus, Cricetulus griseus, Columba sp., Oryctolagus cuniculus, Homo sapiens, Platyrrhini, Mus musculus, Rattus norvegicus, Sus scrofa
Lu, X.; Lin, S.; Chang, C.C.Y.; Chang, T.
Mutant acyl-coenzyme A: cholesterol acyltransferase 1 devoid of cysteine residues remains catalytically active
J. Biol. Chem.
277
711-718
2002
Homo sapiens
Yu, C.; Zhang, Y.; Lu, X.; Chen, J.; Chang, C.C.Y.; Chang, T.
Role of the N-terminal hydrophilic domain of acyl-coenzyme A:cholesterol acyltransferase 1 on the enzymes's quaternary structure and catalytic efficiency
Biochemistry
41
3762-3769
2002
Homo sapiens
Kim, D.H.; Han, K.M.; Chung, I.S.; Kim, D.K.; Kim, S.H.; Kwon, B.M.; Jeong, T.S.; Park, M.H.; Ahn, E.M.; Baek, N.I.
Triterpenoids from the flower of Campsis grandiflora K. Schum. as human acyl-CoA: cholesterol acyltransferase inhibitors
Arch. Pharm. Res.
28
550-556
2005
Homo sapiens
Hori, M.; Miyazaki, A.; Tamagawa, H.; Satoh, M.; Furukawa, K.; Hakamata, H.; Sasaki, Y.; Horiuchi, S.
Up-regulation of acyl-coenzyme A:cholesterol acyltransferase-1 by transforming growth factor-beta1 during differentiation of human monocytes into macrophages
Biochem. Biophys. Res. Commun.
320
501-505
2004
Homo sapiens
Liu, J.; Chang, C.C.; Westover, E.J.; Covey, D.F.; Chang, T.Y.
Investigating the allosterism of acyl coenzyme A: cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies
Biochem. J.
391
389-397
2005
Homo sapiens
Zhang, Y.; Yu, C.; Liu, J.; Spencer, T.A.; Chang, C.C.; Chang, T.Y.
Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1
J. Biol. Chem.
278
11642-11647
2003
Homo sapiens
Liang, J.J.; Oelkers, P.; Guo, C.; Chu, P.C.; Dixon, J.L.; Ginsberg, H.N.; Sturley, S.L.
Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells
J. Biol. Chem.
279
44938-44944
2004
Homo sapiens
Lin, S.; Lu, X.; Chang, C.C.; Chang, T.Y.
Human acyl-coenzyme A:cholesterol acyltransferase expressed in chinese hamster ovary cells: membrane topology and active site location
Mol. Biol. Cell
14
2447-2460
2003
Homo sapiens
Im, K.R.; Jeong, T.S.; Kwon, B.M.; Baek, N.I.; Kim, S.H.; Kim, D.K.
Acyl-CoA: cholesterol acyltransferase inhibitors from Ilex macropoda
Arch. Pharm. Res.
29
191-194
2006
Homo sapiens (O75908), Homo sapiens (P35610)
Suguro, T.; Watanabe, T.; Kanome, T.; Kodate, S.; Hirano, T.; Miyazaki, A.; Adachi, M.
Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages
Atherosclerosis
186
275-281
2006
Homo sapiens (P35610), Homo sapiens
Song, B.L.; Wang, C.H.; Yao, X.M.; Yang, L.; Zhang, W.J.; Wang, Z.Z.; Zhao, X.N.; Yang, J.B.; Qi, W.; Yang, X.Y.; Inoue, K.; Lin, Z.X.; Zhang, H.Z.; Kodama, T.; Chang, C.C.; Liu, Y.K.; Chang, T.Y.; Li, B.L.
Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma
Biochem. J.
394
617-626
2006
Homo sapiens (O75908), Homo sapiens
Guo, Z.Y.; Chang, C.C.; Lu, X.; Chen, J.; Li, B.L.; Chang, T.Y.
The disulfide linkage and the free sulfhydryl accessibility of acyl-coenzyme A:cholesterol acyltransferase 1 as studied by using mPEG5000-maleimide
Biochemistry
44
6537-6546
2005
Homo sapiens (P35610), Homo sapiens
Park, Y.D.; Lee, W.S.; An, S.; Jeong, T.S.
Human acyl-CoA: cholesterol acyltransferase inhibitory activities of aliphatic acid amides from Zanthoxylum piperitum DC
Biol. Pharm. Bull.
30
205-207
2007
Homo sapiens, Homo sapiens (O75908), Homo sapiens (P35610)
Jeong, T.; Kim, K.S.; Yu, H.; Kim, M.J.; Cho, K.; Choi, Y.; Kim, H.; Park, H.; Lee, W.S.
Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors
Bioorg. Med. Chem. Lett.
15
385-388
2005
Homo sapiens (O75908), Homo sapiens (P35610), Homo sapiens
Kharbanda, R.K.; Wallace, S.; Walton, B.; Donald, A.; Cross, J.M.; Deanfield, J.
Systemic Acyl-CoA:cholesterol acyltransferase inhibition reduces inflammation and improves vascular function in hypercholesterolemia
Circulation
111
804-807
2005
Homo sapiens
An, S.; Cho, K.H.; Lee, W.S.; Lee, J.O.; Paik, Y.K.; Jeong, T.S.
A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2
FEBS Lett.
580
2741-2749
2006
Homo sapiens (O75908), Homo sapiens (P35610)
Song, M.C.; Yang, H.J.; Jeong, T.S.; Kim, K.T.; Baek, N.I.
Heterocyclic compounds from Chrysanthemum coronarium L. and their inhibitory activity on hACAT-1, hACAT-2, and LDL-oxidation
Arch. Pharm. Res.
31
573-578
2008
Homo sapiens
Fujiwara, Y.; Kiyota, N.; Hori, M.; Matsushita, S.; Iijima, Y.; Aoki, K.; Shibata, D.; Takeya, M.; Ikeda, T.; Nohara, T.; Nagai, R.
Esculeogenin A, a new tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in ApoE-deficient mice by inhibiting ACAT
Arterioscler. Thromb. Vasc. Biol.
27
2400-2406
2007
Homo sapiens, Mus musculus
Parini, P.; Gustafsson, U.; Davis, M.A.; Larsson, L.; Einarsson, C.; Wilson, M.; Rudling, M.; Tomoda, H.; Omura, S.; Sahlin, S.; Angelin, B.; Rudel, L.L.; Eriksson, M.
Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2
Arterioscler. Thromb. Vasc. Biol.
28
1200-1206
2008
Homo sapiens
Terasaka, N.; Miyazaki, A.; Kasanuki, N.; Ito, K.; Ubukata, N.; Koieyama, T.; Kitayama, K.; Tanimoto, T.; Maeda, N.; Inaba, T.
ACAT inhibitor pactimibe sulfate (CS-505) reduces and stabilizes atherosclerotic lesions by cholesterol-lowering and direct effects in apolipoprotein E-deficient mice
Atherosclerosis
190
239-247
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Ikenoya, M.; Yoshinaka, Y.; Kobayashi, H.; Kawamine, K.; Shibuya, K.; Sato, F.; Sawanobori, K.; Watanabe, T.; Miyazaki, A.
A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels
Atherosclerosis
191
290-297
2007
Homo sapiens
Pramfalk, C.; Angelin, B.; Eriksson, M.; Parini, P.
Cholesterol regulates ACAT2 gene expression and enzyme activity in human hepatoma cells
Biochem. Biophys. Res. Commun.
364
402-409
2007
Homo sapiens
An, S.; Park, Y.; Paik, Y.; Jeong, T.; Lee, W.S.
Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon
Bioorg. Med. Chem. Lett.
17
1112-1116
2007
Homo sapiens
Kitamura, A.; Imai, S.; Yabuki, M.; Komuro, S.
The new acyl-CoA cholesterol acyltransferase inhibitor SMP-797 does not interact with statins via OATP1B1 in human cryopreserved hepatocytes and oocytes expressing systems
Biopharm. Drug Dispos.
28
517-525
2007
Homo sapiens
Lee, J.H.; Ryu, Y.B.; Lee, B.W.; Kim, J.H.; Lee, W.S.; Park, Y.; Jeong, T.; Park, K.H.
Human acyl-CoA:cholesterol acyltransferase (hACAT) inhibitory activities of triterpenoids from roots of Glycine max (L.) merr
Bull. Korean Chem. Soc.
29
615-619
2008
Homo sapiens
-
An, S.; Jang, Y.S.; Park, J.S.; Kwon, B.M.; Paik, Y.K.; Jeong, T.S.
Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes
Exp. Mol. Med.
40
407-417
2008
Homo sapiens
Choi, J.H.; Rho, M.; Lee, S.W.; Kwon, O.E.; Park, H.R.; Kang, J.Y.; Lee, S.H.; Lee, H.S.; Bae, K.H.; Kim, Y.K.
Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots
J. Ethnopharmacol.
110
563-566
2007
Homo sapiens, Rattus norvegicus
He, P.; Cheng, B.; Wang, Y.; Wang, H.
Effect of tumor necrosis factor-alpha on acyl coenzyme A: cholesteryl acyltransferase activity and ACAT1 gene expression in THP-1 macrophages
J. Huazhong Univ. Sci. Technol. Med. Sci.
27
170-172
2007
Homo sapiens
Miike, T.; Shirahase, H.; Jino, H.; Kunishiro, K.; Kanda, M.; Kurahashi, K.
Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells
Life Sci.
82
79-84
2008
Homo sapiens
Rho, M.; Lee, S.W.; Park, H.R.; Choi, J.; Kang, J.Y.; Kim, K.; Lee, H.S.; Kim, Y.K.
ACAT inhibition of alkamides identified in the fruits of Piper nigrum
Phytochemistry
68
899-903
2007
Homo sapiens, Rattus norvegicus
Jin, Y.; Rho, M.; Gajulapati, K.; Jung, H.; Boovanahalli, S.; Lee, J.; Song, G.; Choi, J.; Kim, Y.; Lee, K.; Choi, Y.
Synthesis of a novel series of imidazo[1,2-alpha]pyridines as acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitors
Bull. Korean Chem. Soc.
30
1297-1304
2009
Homo sapiens
-
Xin, C.; Yan-Fu, W.; Ping, H.; Jing, G.; Jing-Jing, W.; Chun-Li, M.; Wei, L.; Bei, C.
Study of the insulin signaling pathways in the regulation of ACAT1 expression in cultured macrophages
Cell Biol. Int.
33
602-606
2009
Homo sapiens
Kanome, T.; Watanabe, T.; Nishio, K.; Takahashi, K.; Hongo, S.; Miyazaki, A.
Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages
Hypertens. Res.
31
1801-1810
2008
Homo sapiens
Antalis, C.J.; Arnold, T.; Lee, B.; Buhman, K.K.; Siddiqui, R.A.
Docosahexaenoic acid is a substrate for ACAT1 and inhibits cholesteryl ester formation from oleic acid in MCF-10A cells
Prostaglandins Leukot. Essent. Fatty Acids
80
165-171
2009
Homo sapiens
Locke, J.; Wasan, K.; Nelson, C.; Guns, E.; Leon, C.
Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:cholesterol acyltransferase (ACAT)
Prostate
68
20-33
2008
Homo sapiens
Chang, C.C.; Miyazaki, A.; Dong, R.; Kheirollah, A.; Yu, C.; Geng, Y.; Higgs, H.N.; Chang, T.Y.
Purification of recombinant acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) from H293 cells and binding studies between the enzyme and substrates using difference intrinsic fluorescence spectroscopy
Biochemistry
49
9957-9963
2010
Homo sapiens
Hu, H.; Liao, H.; Zhang, J.; Wu, W.; Yan, J.; Yan, Y.; Zhao, Q.; Zou, Y.; Chai, X.; Yu, S.; Wu, Q.
First identification of xanthone sulfonamides as potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors
Bioorg. Med. Chem. Lett.
20
3094-3097
2010
Homo sapiens
Rogers, M.A.; Liu, J.; Kushnir, M.M.; Bryleva, E.; Rockwood, A.L.; Meikle, A.W.; Shapiro, D.; Vaisman, B.L.; Remaley, A.T.; Chang, C.C.; Chang, T.Y.
Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase
J. Biol. Chem.
287
17483-17492
2012
Homo sapiens (O75908), Homo sapiens (P35610)
Ohtawa, M.; Yamazaki, H.; Ohte, S.; Matsuda, D.; Ohshiro, T.; Rudel, L.L.; Omura, S.; Tomoda, H.; Nagamitsu, T.
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1
Bioorg. Med. Chem. Lett.
23
1285-1287
2013
Homo sapiens (O75908), Homo sapiens (P35610)
Ohtawa, M.; Yamazaki, H.; Matsuda, D.; Ohshiro, T.; Rudel, L.L.; Omura, S.; Tomoda, H.; Nagamitsu, T.
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2
Bioorg. Med. Chem. Lett.
23
2659-2662
2013
Homo sapiens (O75908), Homo sapiens (P35610)
Ohtawa, M.; Yamazaki, H.; Ohte, S.; Matsuda, D.; Ohshiro, T.; Rudel, L.L.; Omura, S.; Tomoda, H.; Nagamitsu, T.
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3
Bioorg. Med. Chem. Lett.
23
3798-3801
2013
Homo sapiens (O75908), Homo sapiens (P35610)
He, X.; Leow, K.Y.; Yang, H.; Heng, C.K.
Functional characterization of two single nucleotide polymorphisms of acyl-coenzyme A:cholesterol acyltransferase 2
Gene
566
236-241
2015
Homo sapiens (O75908), Homo sapiens
Tomita, K.; Teratani, T.; Suzuki, T.; Shimizu, M.; Sato, H.; Narimatsu, K.; Usui, S.; Furuhashi, H.; Kimura, A.; Nishiyama, K.; Maejima, T.; Okada, Y.; Kurihara, C.; Shimamura, K.; Ebinuma, H.; Saito, H.; Yokoyama, H.; Watanabe, C.; Komoto, S.; Nagao, S.; Sugiyama, K.; Aosasa, S.; Hatsuse, K.; Yamamoto, J.; Hibi, T.; Miura, S.; Hokari, R.; Kanai, T.
Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells
J. Hepatol.
61
98-106
2014
Homo sapiens (P35610), Mus musculus (Q61263), Mus musculus C57BL/6 (Q61263)
Rogers, M.A.; Liu, J.; Song, B.L.; Li, B.L.; Chang, C.C.; Chang, T.Y.
Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): enzymes with multiple sterols as substrates and as activators
J. Steroid Biochem. Mol. Biol.
151
102-107
2015
Homo sapiens (O75908), Homo sapiens (P35610), Homo sapiens, Mus musculus (O88908), Mus musculus (Q61263)
Zhan, Y.; Zhang, X.W.; Xiong, Y.; Li, B.L.; Nan, F.J.
Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2)
Org. Biomol. Chem.
14
747-751
2015
Homo sapiens
Neumann, B.; Chang, C.C.Y.; Chang, T.Y.
Triton X-100 or octyl glucoside inactivates acyl-CoA cholesterol acyltransferase 1 by dissociating it from a two-fold dimer to a two-fold monomer
Arch. Biochem. Biophys.
671
103-110
2019
Homo sapiens (P35610)
Smith, D.C.; Kroiss, M.; Kebebew, E.; Habra, M.A.; Chugh, R.; Schneider, B.J.; Fassnacht, M.; Jafarinasabian, P.; Ijzerman, M.M.; Lin, V.H.; Mohideen, P.; Naing, A.
A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma
Invest. New Drugs
38
1421-1429
2020
Homo sapiens (P35610), Homo sapiens
Ohshiro, T.; Seki, R.; Fukuda, T.; Uchida, R.; Tomoda, H.
Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307
J. Antibiot.
71
1000-1007
2018
Homo sapiens (O75908), Homo sapiens (P35610), Chlorocebus aethiops (O77759), Chlorocebus aethiops (O77760)
Iwasaki, A.; Tadenuma, T.; Sumimoto, S.; Ohshiro, T.; Ozaki, K.; Kobayashi, K.; Teruya, T.; Tomoda, H.; Suenaga, K.
Biseokeaniamides A, B, and C, sterol O-Acyltransferase inhibitors from an Okeania sp. marine cyanobacterium
J. Nat. Prod.
80
1161-1166
2017
Homo sapiens (O75908), Homo sapiens (P35610), Homo sapiens
Zhan, Y.; Zhang, X.; Xiong, Y.; Li, B.; Nan, F.
Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A Cholesterol acyltransferase 2 (ACAT2)
Org. Biomol. Chem.
14
747-751
2016
Homo sapiens (O75908)
Ayyagari, V.N.; Wang, X.; Diaz-Sylvester, P.L.; Groesch, K.; Brard, L.
Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression - An in vitro study
PLoS ONE
15
e0228024
2020
Homo sapiens (P35610)
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