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dihydrosphingosine + myristoyl-CoA
N-myristoyldihydrosphingosine + CoA
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-
-
?
dihydrosphingosine + palmitoyl-CoA
N-palmitoyldihydrosphingosine + CoA
dihydrosphingosine + stearoyl-CoA
N-stearoyldihydrosphingosine + CoA
-
-
-
?
docosanoyl-CoA + sphingosine
CoA + N-docosanoylsphingosine
-
-
-
?
eicosanoyl-CoA + sphingosine
CoA + N-eicosanoylsphingosine
-
-
-
?
hexacosanoyl-CoA + sphingosine
CoA + N-hexacosanoylsphingosine
-
-
-
?
palmitoyl-CoA + sphingosine
CoA + N-palmitoylsphingosine
palmitoyl-CoA + sphingosine
CoA + palmitoylsphingosine
sphinganine + arachidoyl-CoA
N-arachidoylsphinganine + CoA
-
-
-
?
sphinganine + palmitoyl-CoA
N-palmitoyl-DL-dihydrosphingosine + CoA
-
-
-
-
?
sphinganine + palmitoyl-CoA
N-palmitoylsphinganine + CoA
sphinganine + stearoyl-CoA
N-stearoylsphinganine + CoA
-
-
-
?
sphingosine + 2-hydroxy-palmitoyl-CoA
N-2-hydroxy-palmitoyl-sphingosine + CoA
-
-
-
?
sphingosine + eicosanoyl-CoA
N-eicosanoylsphingosine + CoA
-
-
-
?
sphingosine + palmitoyl-CoA
N-palmitoylsphingosine + CoA
stearoyl-CoA + sphingosine
CoA + N-stearoylsphingosine
-
-
-
?
tetracosanoyl-CoA + sphingosine
CoA + N-tetracosanoylsphingosine
-
-
-
?
additional information
?
-
dihydrosphingosine + palmitoyl-CoA
N-palmitoyldihydrosphingosine + CoA
-
-
-
?
dihydrosphingosine + palmitoyl-CoA
N-palmitoyldihydrosphingosine + CoA
best substrate
-
-
?
palmitoyl-CoA + sphingosine
CoA + N-palmitoylsphingosine
-
-
-
?
palmitoyl-CoA + sphingosine
CoA + N-palmitoylsphingosine
-
-
-
?
palmitoyl-CoA + sphingosine
CoA + palmitoylsphingosine
-
-
-
?
palmitoyl-CoA + sphingosine
CoA + palmitoylsphingosine
-
-
-
?
sphinganine + palmitoyl-CoA
N-palmitoylsphinganine + CoA
-
-
-
?
sphinganine + palmitoyl-CoA
N-palmitoylsphinganine + CoA
-
-
-
?
sphinganine + palmitoyl-CoA
N-palmitoylsphinganine + CoA
-
-
-
?
sphinganine + palmitoyl-CoA
N-palmitoylsphinganine + CoA
-
-
-
?
sphingosine + palmitoyl-CoA
N-palmitoylsphingosine + CoA
-
-
-
?
sphingosine + palmitoyl-CoA
N-palmitoylsphingosine + CoA
-
-
-
?
additional information
?
-
substrate specificity, overview
-
-
?
additional information
?
-
substrate specificity, overview
-
-
?
additional information
?
-
CERS4 transfers C18 and C20 fatty acids
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-
?
additional information
?
-
CERS4 transfers C18 and C20 fatty acids
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-
?
additional information
?
-
CERS4 transfers C18 and C20 fatty acids
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-
?
additional information
?
-
CERS5 transfers C16 fatty acids, and potentially also C14 and C18 fatty acids
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-
?
additional information
?
-
CERS5 transfers C16 fatty acids, and potentially also C14 and C18 fatty acids
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-
?
additional information
?
-
CERS5 transfers C16 fatty acids, and potentially also C14 and C18 fatty acids
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-
?
additional information
?
-
CerS6 lysate produces nonhydroxy-dihydro-ceramides that included strong bands for C14:0- and C16:0-dihydro-ceramide, but a weak band for C18:0-dihydro-ceramide
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-
?
additional information
?
-
CerS6 lysate produces nonhydroxy-dihydro-ceramides that included strong bands for C14:0- and C16:0-dihydro-ceramide, but a weak band for C18:0-dihydro-ceramide
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-
?
additional information
?
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CERS6 transfers C14 and C16 fatty acids
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-
?
additional information
?
-
CERS6 transfers C14 and C16 fatty acids
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-
?
additional information
?
-
CERS6 transfers C14 and C16 fatty acids
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-
?
additional information
?
-
CERS activity is assayed using LC-MS/MS for product quantification, crude extracts containing cell membranes are firstly prepared from tissues or cultured cells, reactions contain deuterated dihydrosphingosine (or sphingosine) and a fatty acid substrate linked to CoA (C16:0 to C24:0/24:1), detailed method descritpion and evaluation, overview
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-
?
additional information
?
-
CERS activity is assayed using LC-MS/MS for product quantification, crude extracts containing cell membranes are firstly prepared from tissues or cultured cells, reactions contain deuterated dihydrosphingosine (or sphingosine) and a fatty acid substrate linked to CoA (C16:0 to C24:0/24:1), detailed method descritpion and evaluation, overview
-
-
?
additional information
?
-
CERS activity is assayed using LC-MS/MS for product quantification, crude extracts containing cell membranes are firstly prepared from tissues or cultured cells, reactions contain deuterated dihydrosphingosine (or sphingosine) and a fatty acid substrate linked to CoA (C16:0 to C24:0/24:1), detailed method descritpion and evaluation, overview
-
-
?
additional information
?
-
expression of CERS3 increases the levels of C18-C22-ceramides, whereas it reduces the levels of C16:0-ceramide and C24-ceramides
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-
-
additional information
?
-
expression of CERS3 increases the levels of C18-C22-ceramides, whereas it reduces the levels of C16:0-ceramide and C24-ceramides
-
-
-
additional information
?
-
expression of CERS3 increases the levels of C18-C22-ceramides, whereas it reduces the levels of C16:0-ceramide and C24-ceramides
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-
-
additional information
?
-
expression of CERS3 increases the levels of C18-C22-ceramides, whereas it reduces the levels of C16:0-ceramide and C24-ceramides
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-
-
additional information
?
-
expression of CERS3 increases the levels of C18-C22-ceramides, whereas it reduces the levels of C16:0-ceramide and C24-ceramides
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-
-
additional information
?
-
expression of CERS3 increases the levels of C26:0-ceramide as well as those of C18:0-ceramide, C20:0-ceramide, and C24:0-ceramide, whereas it reduces the level of C16:0-ceramide
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-
-
additional information
?
-
expression of CERS3 increases the levels of C26:0-ceramide as well as those of C18:0-ceramide, C20:0-ceramide, and C24:0-ceramide, whereas it reduces the level of C16:0-ceramide
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-
-
additional information
?
-
expression of CERS3 increases the levels of C26:0-ceramide as well as those of C18:0-ceramide, C20:0-ceramide, and C24:0-ceramide, whereas it reduces the level of C16:0-ceramide
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-
-
additional information
?
-
expression of CERS3 increases the levels of C26:0-ceramide as well as those of C18:0-ceramide, C20:0-ceramide, and C24:0-ceramide, whereas it reduces the level of C16:0-ceramide
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-
-
additional information
?
-
expression of CERS3 increases the levels of C26:0-ceramide as well as those of C18:0-ceramide, C20:0-ceramide, and C24:0-ceramide, whereas it reduces the level of C16:0-ceramide
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-
-
additional information
?
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expression of CERS5 increases the level of C16:0-ceramide and decreases levels of C18:0-ceramide, C22:0-ceramide, and C24-ceramides
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-
-
additional information
?
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expression of CERS5 increases the level of C16:0-ceramide and decreases levels of C18:0-ceramide, C22:0-ceramide, and C24-ceramides
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-
-
additional information
?
-
expression of CERS5 increases the level of C16:0-ceramide and decreases levels of C18:0-ceramide, C22:0-ceramide, and C24-ceramides
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-
-
additional information
?
-
expression of CERS5 increases the level of C16:0-ceramide and decreases levels of C18:0-ceramide, C22:0-ceramide, and C24-ceramides
-
-
-
additional information
?
-
expression of CERS5 increases the level of C16:0-ceramide and decreases levels of C18:0-ceramide, C22:0-ceramide, and C24-ceramides
-
-
-
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Adenocarcinoma
CEBP? facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation.
Adenocarcinoma
Ceramide synthases: insights into the expression and prognosis of lung cancer.
Adenocarcinoma of Lung
Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner.
Adenocarcinoma of Lung
Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1.
Alopecia
Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia.
Ataxia
Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase.
Ataxia
ATM regulates target switching to escalating doses of radiation in the intestines.
Atherosclerosis
[Investigating the role of ceramide metabolism-associated CERS5 (LASS5) gene in atherosclerosis pathogenesis in endothelial cells].
Breast Neoplasms
Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer.
Breast Neoplasms
C16?ceramide and sphingosine 1?phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation.
Breast Neoplasms
Ceramide synthases CerS4 and CerS5 are upregulated by 17?-estradiol and GPER1 via AP-1 in human breast cancer cells.
Breast Neoplasms
Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer.
Breast Neoplasms
Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer.
Breast Neoplasms
Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.
Breast Neoplasms
Long non-coding RNA CERS6-AS1 facilitates the oncogenicity of pancreatic ductal adenocarcinoma by regulating the microRNA-15a-5p/FGFR1 axis.
Breast Neoplasms
Long noncoding RNA CERS6-AS1 functions as a malignancy promoter in breast cancer by binding to IGF2BP3 to enhance the stability of CERS6 mRNA.
Carcinogenesis
AKT1/FOXP3 axis-mediated expression of CerS6 promotes p53 mutant pancreatic tumorigenesis.
Carcinogenesis
Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation.
Carcinogenesis
Ceramide synthase 6 predicts the prognosis of human gastric cancer: It functions as an oncoprotein by dysregulating the SOCS2/JAK2/STAT3 pathway.
Carcinoma
Ceramide synthases: insights into the expression and prognosis of lung cancer.
Carcinoma
CerS6 regulates cisplatin resistance in oral squamous cell carcinoma by altering mitochondrial fission and autophagy.
Carcinoma
Fumonisin B1 Inhibits Endoplasmic Reticulum Stress Associated-apoptosis After FoscanPDT Combined with C6-Pyridinium Ceramide or Fenretinide.
Carcinoma, Hepatocellular
Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels.
Carcinoma, Hepatocellular
Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.
Carcinoma, Squamous Cell
Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells.
Carcinoma, Squamous Cell
Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization.
Carcinoma, Squamous Cell
Ceramide synthases: insights into the expression and prognosis of lung cancer.
Carcinoma, Squamous Cell
Fumonisin B1 Inhibits Endoplasmic Reticulum Stress Associated-apoptosis After FoscanPDT Combined with C6-Pyridinium Ceramide or Fenretinide.
Colitis
Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability.
Colitis
Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis.
Colitis
Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation.
Colitis
Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis.
Colitis-Associated Neoplasms
Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation.
Colonic Neoplasms
Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.
Colonic Neoplasms
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1.
Colonic Neoplasms
Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy.
Colonic Neoplasms
Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner.
Colonic Neoplasms
Linking the ceramide synthases (CerSs) 4 and 5 with apoptosis, endometrial and colon cancers.
Colorectal Neoplasms
High CerS5 expression levels associate with reduced patient survival and transition from apoptotic to autophagy signalling pathways in colorectal cancer.
Colorectal Neoplasms
Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer.
Cough
Ceramide: a key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation.
Cystic Fibrosis
Fenretinide differentially modulates the levels of long- and very long-chain ceramides by downregulating Cers5 enzyme: evidence from bench to bedside.
Cytochrome-c Oxidase Deficiency
Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.
Dementia
Gangliosides' protection against lysosomal pathology of synucleinopathies.
Dermatitis, Atopic
Ceramide synthase 4 is highly expressed in involved skin of patients with atopic dermatitis.
Diabetes Mellitus
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.
Diabetes Mellitus, Type 2
Noncoding Variations in the Gene Encoding Ceramide Synthase 6 are Associated with Type 2 Diabetes in a Large Indigenous Australian Pedigree.
Diabetes Mellitus, Type 2
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.
Diabetes Mellitus, Type 2
The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach.
Dyspnea
Ceramide: a key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation.
Encephalomyelitis
Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis.
Encephalomyelitis
Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.
Encephalomyelitis
Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent.
Encephalomyelitis, Autoimmune, Experimental
Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.
Encephalomyelitis, Autoimmune, Experimental
Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent.
Fatty Liver
Ceramide Synthases Are Attractive Drug Targets for Treating Metabolic Diseases.
Glioblastoma
Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.
Glioblastoma
PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.
Head and Neck Neoplasms
Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.
Heart Failure
A tissue-specific screen of ceramide expression in aged mice identifies ceramide synthase-1 and ceramide synthase-5 as potential regulators of fiber size and strength in skeletal muscle.
Hematologic Neoplasms
Ceramide synthesis regulates T cell activity and GVHD development.
Hyperglycemia
The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach.
Hypertrophy, Right Ventricular
Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.
Hypothyroidism
[Analysis of genes related to hypothyroidism during pregnancy].
Ichthyosis
Comprehensive stratum corneum ceramide profiling reveals reduced acylceramides in ichthyosis patient with CERS3 mutations.
Infections
Specific processing of poly(ADP-ribose) polymerase, accompanied by activation of caspase-3 and elevation/reduction of ceramide/hydrogen peroxide levels, during induction of apoptosis in host HL-60 cells infected by the human granulocytic ehrlichiosis (HGE) agent.
Insulin Resistance
Ceramide Synthases Are Attractive Drug Targets for Treating Metabolic Diseases.
Insulin Resistance
CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance.
Insulin Resistance
CerS2 haploinsufficiency inhibits ?-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.
Insulin Resistance
CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.
Insulin Resistance
Downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes.
Insulin Resistance
Mechanistic interplay between ceramide and insulin resistance.
Insulin Resistance
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.
Insulin Resistance
The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach.
Leishmaniasis
Residue-Specific Message Encoding in CD40-Ligand.
Leukemia
By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, stichoposide D inhibits growth of leukemia xenografts.
Leukemia
Holotoxin A? Induces Apoptosis by Activating Acid Sphingomyelinase and Neutral Sphingomyelinase in K562 and Human Primary Leukemia Cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
A novel mechanism of dasatinib-induced apoptosis in chronic myeloid leukemia; ceramide synthase and ceramide clearance genes.
Liver Diseases
LASS2 regulates hepatocyte steatosis by interacting with NDUFS2/OXPHOS related proteins.
Liver Diseases, Alcoholic
A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis.
Liver Neoplasms
Ceramide synthase-4 orchestrates the cell proliferation and tumor growth of liver cancer in vitro and in vivo through the nuclear factor-?B signaling pathway.
Lung Neoplasms
CEBP? facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation.
Lung Neoplasms
CERS6 required for cell migration and metastasis in lung cancer.
Lung Neoplasms
Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells.
Lymphatic Metastasis
CERS6 required for cell migration and metastasis in lung cancer.
Magnesium Deficiency
Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues and cells: cross-talk among cytokines, Mg2+, NF-?B, and de novo ceramide.
Melanoma
Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer.
Melanoma
Silencing of CerS6 increases the invasion and glycolysis of melanoma WM35, WM451 and SK28 cell lines via increased GLUT1-induced downregulation of WNT5A.
Metabolic Diseases
CerS2 haploinsufficiency inhibits ?-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.
Metabolic Syndrome
[Analysis of genes related to hypothyroidism during pregnancy].
Mitochondrial Diseases
Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.
Multiple Sclerosis
Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.
Neoplasm Metastasis
CEBP? facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation.
Neoplasm Metastasis
Ceramide synthase 6 predicts poor prognosis and activates the AKT/mTOR/4EBP1 pathway in high-grade serous ovarian cancer.
Neoplasm Metastasis
CERS6 required for cell migration and metastasis in lung cancer.
Neoplasm Metastasis
Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3.
Neoplasm Metastasis
Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells.
Neoplasms
17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species.
Neoplasms
Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer.
Neoplasms
AKT1/FOXP3 axis-mediated expression of CerS6 promotes p53 mutant pancreatic tumorigenesis.
Neoplasms
Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network.
Neoplasms
Altered mRNA expression levels of the major components of sphingolipid metabolism, ceramide synthases and their clinical implication in colorectal cancer.
Neoplasms
Anti-inflammatory and anti-apoptotic effects of fumonisin B1, an inhibitor of ceramide synthase, in a rodent model of splanchnic ischemia and reperfusion injury.
Neoplasms
C16?ceramide and sphingosine 1?phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation.
Neoplasms
Carcinogenicity and mechanism of action of fumonisin B1: a mycotoxin produced by Fusarium moniliforme (= F. verticillioides).
Neoplasms
CEBP? facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation.
Neoplasms
Ceramide accumulation is associated with increased apoptotic cell death in cultured fibroblasts of sphingolipid activator protein-deficient mouse but not in fibroblasts of patients with Farber disease.
Neoplasms
Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner.
Neoplasms
Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells.
Neoplasms
Ceramide synthase 6 predicts poor prognosis and activates the AKT/mTOR/4EBP1 pathway in high-grade serous ovarian cancer.
Neoplasms
Ceramide synthase 6 predicts the prognosis of human gastric cancer: It functions as an oncoprotein by dysregulating the SOCS2/JAK2/STAT3 pathway.
Neoplasms
Ceramide synthase-4 orchestrates the cell proliferation and tumor growth of liver cancer in vitro and in vivo through the nuclear factor-?B signaling pathway.
Neoplasms
Ceramide synthases CerS4 and CerS5 are upregulated by 17?-estradiol and GPER1 via AP-1 in human breast cancer cells.
Neoplasms
CerS6 regulates cisplatin resistance in oral squamous cell carcinoma by altering mitochondrial fission and autophagy.
Neoplasms
Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation.
Neoplasms
Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer.
Neoplasms
Decreased fumonisin hepatotoxicity in mice with a targeted deletion of tumor necrosis factor receptor 1.
Neoplasms
Dihydroceramide desaturase knockdown impacts sphingolipids and apoptosis after photodamage in human head and neck squamous carcinoma cells.
Neoplasms
Diverse functions of ceramide in cancer cell death and proliferation.
Neoplasms
Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility.
Neoplasms
Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice.
Neoplasms
Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3.
Neoplasms
Fumonisin B1 regulates LDL receptor and ABCA1 expression in an LXR dependent mechanism in liver (HepG2) cells.
Neoplasms
Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition.
Neoplasms
High CerS5 expression levels associate with reduced patient survival and transition from apoptotic to autophagy signalling pathways in colorectal cancer.
Neoplasms
Increased liver tumor formation in neutral sphingomyelinase-2 deficient mice.
Neoplasms
Increased susceptibility of renal epithelial cells to TNFalpha-induced apoptosis following treatment with fumonisin B1.
Neoplasms
Inhibition of tumor necrosis factor alpha signaling by anti-tumor necrosis factor alpha antibodies and pentoxifylline is unable to prevent fumonisin hepatotoxicity in mice.
Neoplasms
LASS2 inhibits proliferation and induces apoptosis in HepG2 cells by affecting mitochondrial dynamics, the cell cycle and the nuclear factor??B pathways.
Neoplasms
LASS5 Interacts with SDHB and Synergistically Represses p53 and p21 Activity.
Neoplasms
Linking the ceramide synthases (CerSs) 4 and 5 with apoptosis, endometrial and colon cancers.
Neoplasms
Long noncoding RNA CERS6-AS1 functions as a malignancy promoter in breast cancer by binding to IGF2BP3 to enhance the stability of CERS6 mRNA.
Neoplasms
Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells.
Neoplasms
Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent.
Neoplasms
S-adenosylmethionine or 5'-methylthioadenosine are unable to prevent fumonisin B1 hepatotoxicity in mice despite increased oxidation in liver.
Neoplasms
Silencing of CerS6 increases the invasion and glycolysis of melanoma WM35, WM451 and SK28 cell lines via increased GLUT1-induced downregulation of WNT5A.
Neoplasms
Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases.
Neoplasms
Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling.
Neoplasms
Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.
Neoplasms
Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.
Neoplasms
Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation.
Neoplasms
The novel HDAC inhibitor AR-42-induced anti-colon cancer cell activity is associated with ceramide production.
Neoplasms
Tolerance to fumonisin toxicity in a mouse strain lacking the P75 tumor necrosis factor receptor.
Neoplasms
[Ceramide: a lipid mediator of apoptotic signal transduction]
Neoplasms
[pemetrexed + sildenafil], via autophagy-dependent HDAC down-regulation, enhances the immunotherapy response of NSCLC cells.
Neuroblastoma
Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide.
Neuroblastoma
Gangliosides' protection against lysosomal pathology of synucleinopathies.
Neuroblastoma
N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase.
Neurodegenerative Diseases
Assaying Ceramide Synthase Activity In Vitro and in Living Cells Using Liquid Chromatography-Mass Spectrometry.
Neurodegenerative Diseases
Defective ceramide synthases in mice cause reduced amplitudes in electroretinograms and altered sphingolipid composition in retina and cornea.
Non-alcoholic Fatty Liver Disease
LASS2 regulates hepatocyte steatosis by interacting with NDUFS2/OXPHOS related proteins.
Obesity
Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity.
Obesity
Ceramide Synthases Are Attractive Drug Targets for Treating Metabolic Diseases.
Obesity
CerS2 haploinsufficiency inhibits ?-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.
Obesity
CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.
Obesity
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.
Obesity
The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach.
Ovarian Neoplasms
Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells.
Ovarian Neoplasms
Ceramide synthase 6 predicts poor prognosis and activates the AKT/mTOR/4EBP1 pathway in high-grade serous ovarian cancer.
Ovarian Neoplasms
Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer.
Ovarian Neoplasms
Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.
Pancreatic Neoplasms
Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.
Photosensitivity Disorders
Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization.
Plant Diseases
Alteration in sphingolipid metabolism: bioassays for fumonisin- and ISP-I-like activity in tissues, cells and other matrices.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia.
Prostatic Neoplasms
Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production.
Prostatic Neoplasms
Ceramide accumulation is independent of camptothecin-induced apoptosis in prostate cancer LNCaP cells.
Prostatic Neoplasms
Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis.
Prostatic Neoplasms
PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo.
Rectal Neoplasms
Altered mRNA expression levels of the major components of sphingolipid metabolism, ceramide synthases and their clinical implication in colorectal cancer.
Reperfusion Injury
Anti-inflammatory and anti-apoptotic effects of fumonisin B1, an inhibitor of ceramide synthase, in a rodent model of splanchnic ischemia and reperfusion injury.
Retinal Dystrophies
Ceramide synthase TLCD3B is a novel gene associated with human recessive retinal dystrophy.
sphinganine-1-phosphate aldolase deficiency
S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake.
sphingomyelin phosphodiesterase deficiency
Increased liver tumor formation in neutral sphingomyelinase-2 deficient mice.
sphingosine n-acyltransferase deficiency
Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia.
sphingosine n-acyltransferase deficiency
Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation.
sphingosine n-acyltransferase deficiency
Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis.
sphingosine n-acyltransferase deficiency
Defective ceramide synthases in mice cause reduced amplitudes in electroretinograms and altered sphingolipid composition in retina and cornea.
sphingosine n-acyltransferase deficiency
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.
Squamous Cell Carcinoma of Head and Neck
CerS6 regulates cisplatin resistance in oral squamous cell carcinoma by altering mitochondrial fission and autophagy.
Squamous Cell Carcinoma of Head and Neck
Fumonisin B1 Inhibits Endoplasmic Reticulum Stress Associated-apoptosis After FoscanPDT Combined with C6-Pyridinium Ceramide or Fenretinide.
Starvation
Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila.
Stomach Neoplasms
Ceramide synthase 6 predicts the prognosis of human gastric cancer: It functions as an oncoprotein by dysregulating the SOCS2/JAK2/STAT3 pathway.
Stomach Neoplasms
Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer.
Stomach Neoplasms
Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase.
Stomach Ulcer
Attenuation of Acetic Acid-Induced Gastric Ulcer Formation in Rats by Glucosylceramide Synthase Inhibitors.
Thrombosis
Ceramidase critically affects GPVI-dependent platelet activation and thrombus formation.
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malfunction
CerS6 knockdown might decrease apoptosis compared to normal irradiated HeLa cells
malfunction
inhibition of CerS is able to protect from cell death. Moreover, this protection occurs downstream or independently of mitochondrial permeabilization. Inhibition of CerS greatly inhibits plasma membrane permeabilization. Combined knockdown of CerS5 and CerS6 is able to decrease long-chain ceramide accumulation and plasma membrane permeabilization. Individual CerS knockdown does not significantly inhibit total ceramide accumulation, CerS6 knockdown clearly decreases C14:0- and C16:0-Cer basally and reduces their accumulation following UV-C irradiation, CerS5 knockdown has no appreciable effects on Cer levels. Inhibition of CerS but not de novo synthesis inhibits plasma membrane rupture that is not specific to UV-C irradiation or MCF-7 cells
malfunction
inhibition of CerS is able to protect from cell death. Moreover, this protection occurs downstream or independently of mitochondrial permeabilization. Inhibition of CerS greatly inhibits plasma membrane permeabilization. Combined knockdown of CerS5 and CerS6 is able to decrease long-chain ceramide accumulation and plasma membrane permeabilization. Individual CerS knockdown does not significantly inhibit total ceramide accumulation, knockdown of CerS6 actually even increases total ceramide levels. CerS5 knockdown has no appreciable effects on Cer levels. Inhibition of CerS but not de novo synthesis inhibits plasma membrane rupture that is not specific to UV-C irradiation or MCF-7 cells
malfunction
overexpression of CerS5 increases apoptosis in HeLa cells. CerS2 and CerS5 overexpression significantly alters apoptosis
malfunction
profiles of non-hydroxylated and 2-hydroxy-ceramides in transgenic HeLa cells expressing different CerS isozymes and or different specific interfence RNAs, overview
malfunction
RNAi against CerS6 results in a specific decrease in intracellular C16-ceramide and protects SW-480 cells against TRAIL-mediated apoptosis while increasing CerS6 expression sensitizes SW-620 cells to TRAIL. Downregulation of CerS6 does not interfere with caspase activation but appears to inhibit translocation of activated caspase-3 into the nucleus
malfunction
upon incubation of HEK cells with inhibitor FTY720, an increase in ceramide levels is observed, with no change in endogenous sphinganine levels. Similar increases are observed for hexosylceramide and sphingomyelin. Moreover, levels of C18-C22-ceramide are significantly increased, as were levels of C18-C22-hexosylceramide and C18-C22-sphingomyelin. This result is consistent with a complex mode of interaction of FTY720 with CerS, perhaps involving an allosteric element that is not preserved in vitro, whereby ceramide synthesis is stimulated in cells despite its inhibition by FTY720 in vitro
metabolism
regulation of CerS isozymes, overview. The interplay among the CerS proteins takes place in a stress stimulus-, cell type- and subcellular compartment-specific manner. CerS2 and CerS5 overexpression significantly alters apoptosis, determination of ionizing radiation-induced mitochondrial ceramide elevations via CerS2, 5, and 6, overview. CerS2 and CerS5 overexpressions defines opposing roles in radiation-induced mitochondrial apoptosis
metabolism
regulation of CerS isozymes, overview. The interplay among the CerS proteins takes place in a stress stimulus-, cell type- and subcellular compartment-specific manner. CerS6 overexpression yields no significant differences in IR-induced apoptosis compared to empty vector-transfected cells. Determination of ionizing radiation-induced mitochondrial ceramide elevations via CerS2, 5, and 6, overview
metabolism
regulation of sphingolipid metabolism by UV-C irradiation, overview. Ceramide species that are the least abundant (e.g. C18-Cer, C18:1-Cer, C20-Cer, C22:1-Cer, etc.) exhibit the greatest fold increases. More abundant ceramide species (e.g. C16-Cer, C24-Cer, and C24:1-Cer) show more modest fold changes, although they account for much more of the overall increase in ceramides
metabolism
-
the sphingomyelin pathway, which is initiated by sphingomyelin hydrolysis to generate the second messenger ceramide, signals apoptosis for tumor necrosis factor a, Fas, and ionizing radiation
physiological function
ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. Ceramide synthase 6 (CerS6 also known as longevity assurance homolog 6/LASS6) preferentially generates C16-ceramide and can influence TRAIL susceptibility. CerS6 may regulate events at the nuclear membrane and allow late stage apoptotic signaling
physiological function
-
ceramide synthase mediates daunorubicin-induced apoptosis, an alternative mechanism for generating death signals. Ceramide synthesis appears obligatory for daunorubicin-induced apoptosis, since fumonisin B1, a natural specific inhibitor of ceramide synthase, blocks daunorubicin-induced ceramide elevation and apoptosis. Ceramide mimics daunorubicin in inducing apoptosis
physiological function
ceramides are synthesized by ceramide synthases through the addition of a variable length fatty acid to the amine group of a sphingoid base. In mammalian cells, the sphingoid base used for de novo ceramide synthesis is usually the C18:0 lipid dihydrosphingosine. Ceramide synthesis is catalyzed by a family of six ceramide synthases (CERS1-6), each of which preferentially transfers fatty acids of different lengths to the amine group of dihydrosphingosine
physiological function
differences in the expression patterns of CerS family members may play an important role in the production of the CER/2-hydroxy ceramide (CER) compositions of different chain lengths observed in different cell types and even in the altered production that occurring during keratinocyte differentiation
physiological function
selective tissue and subcellular distribution of the six mammalian CerS isoforms, combined with distinct fatty acyl chain length substrate preferences, implicate differential functions of specific ceramide species in cellular signaling. Ionizing radiation (IR) induces de novo synthesis of ceramide to influence HeLa cell apoptosis by specifically activating isozymes CerS isoforms 2, 5, and 6 that generate opposing anti- and pro-apoptotic ceramides in mitochondrial membranes. Isozymes CerS5 and CerS6 each confer about 50% of the C16:0 CerS baseline synthetic activity, both are required for IR-induced activity. IR-induced CerS-mediated ceramide generation, and subsequent apoptosis, occurs in a cell-type specific manner. CerS2 and CerS5 overexpressions defines opposing roles in radiation-induced mitochondrial apoptosis
physiological function
selective tissue and subcellular distribution of the six mammalian CerS isoforms, combined with distinct fatty acyl chain length substrate preferences, implicate differential functions of specific ceramide species in cellular signaling. Ionizing radiation (IR) induces de novo synthesis of ceramide to influence HeLa cell apoptosis by specifically activating isozymes CerS isoforms 2, 5, and 6 that generate opposing anti- and pro-apoptotic ceramides in mitochondrial membranes. Isozymes CerS5 and CerS6 each confer about 50% of the C16:0 CerS baseline synthetic activity, both are required for IR-induced activity. IR-induced CerS-mediated ceramide generation, and subsequent apoptosis, occurs in a cell-type specific manner. CerS6 overexpression yields no significant differences in IR-induced apoptosis compared to empty vector-transfected cells
physiological function
sphingolipid ceramides are widely implicated in the regulation of programmed cell death or apoptosis. CerS5 and CerS6 regulate C16:0-Cer synthesis. Ceramide synthase inhhibitor fumonisin B1 inhibits cell death, suggesting the presence of a ceramide synthase (CerS)-dependent, sphingosine-derived pool of ceramide in regulating programmed cell death. This pool does not regulate the mitochondrial pathway, but it partially regulates activation of caspase-7 and is necessary for late plasma membrane permeabilization. Mechanisms of its generation and regulatory role during apoptosis, overview
physiological function
nonspecific CerS reduction with fumonisin B1 reduces PLIN2 protein
additional information
chimeric mutant CerS5:TM:CerS2-HA displays slightly more activity using C16-CoA as substrate than CerS5, but remarkably, CerS2 activity measured using C22-CoA is elevated by 3fold. Isozymes CerS5 and CerS6 modulate CerS2 activity upon co-expression. This increase in CerS2 activity is abolished using a noncatalytically active form of CerS5 in the constitutive dimer (CerS5HH:TM:CerS2-HA), demonstrating that optimal CerS2 activity depends on an interaction with a catalytically active form of CerS5
additional information
recombinant FLAG-tagged CerS6 localizes primarily to the perinuclear region
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