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Information on EC 2.3.1.230 - 2-heptyl-4(1H)-quinolone synthase

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EC Tree
IUBMB Comments
The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is a heterodimeric complex. The PqsC subunit acquires an octanoyl group from octanoyl-CoA and attaches it to an internal cysteine residue. Together with the PqsB subunit, the proteins catalyse the coupling of the octanoyl group with (2-aminobenzoyl)acetate, leading to decarboxylation and dehydration events that result in closure of the quinoline ring.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
2-heptyl-4(1h)-quinolone synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1-(2-aminophenyl)decane-1,3-dione = 2-heptyl-4-quinolone + H2O
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(1c)
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octanoyl-CoA + (2-aminobenzoyl)acetate = 2-heptyl-4-quinolone + CoA + CO2 + H2O
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overall reaction
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octanoyl-CoA + L-cysteinyl-[PqsC protein] = S-octanoyl-L-cysteinyl-[PqsC protein] + CoA
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(1a)
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S-octanoyl-L-cysteinyl-[PqsC protein] + (2-aminobenzoyl)acetate = 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]
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(1b)
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