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Information on EC 2.3.1.23 - 1-acylglycerophosphocholine O-acyltransferase and Organism(s) Mus musculus and UniProt Accession Q3TFD2

for references in articles please use BRENDA:EC2.3.1.23
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EC Tree
IUBMB Comments
Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor.
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This record set is specific for:
Mus musculus
UNIPROT: Q3TFD2
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
pcat1, lpcat3, lpcat, lysophosphatidylcholine acyltransferase, alcat1, lpcat2, lysolecithin acyltransferase, lycat, lyso-paf acetyltransferase, lysophosphatidylcholine acyltransferase 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1-acylglycerophosphocholine acyltransferase
-
acyl-CoA:lysophosphatidylcholine acyltransferase
-
LPC acyltransferase
-
lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1
-
lyso-PAF acetyltransferase
-
lyso-PC acyltransferase 1
-
lysoPC acyltransferase
-
lysophosphatidylcholine acyltransferase
-
lysophosphatidylcholine acyltransferase 1
-
lysophosphocholine acyltransferase 1
-
lysophospholipid acyltransferase
-
1-acyl-sn-glycero-3-phosphocholine acyltransferase
-
-
-
-
1-acylglycerol-3-phosphate O-acyltransferase 8
UniProt
1-AGP acyltransferase 8
UniProt
1-AGPAT 8
UniProt
acyl coenzyme A-monoacylphosphatidylcholine acyltransferase
-
-
-
-
acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase
-
-
-
-
acyl-CoA:lysocardiolipin acyltransferase 1
-
acyl-CoA:lysophosphatidylcholine acyltransferase
-
acyltransferase, lysolecithin
-
-
-
-
LPC acyltransferase
-
LPCAT1
-
-
LPCAT4
LPG acyltransferase
-
LPLAT
lyso-PAF acetyltransferase
-
lyso-phosphatidylcholine acyltransferase 1
-
-
lysolecithin acyltransferase
-
-
-
-
lysophosphatide acyltransferase
-
-
-
-
lysophosphatidylcholine acyl transferase
-
lysophosphatidylcholine acyltransferase
-
-
-
-
lysophosphatidylcholine acyltransferase 3
-
lysophosphatidylcholine acyltransferase 4
lysophosphatidylethanolamine acyltransferase 2
-
lysophosphocholine acyltransferase 2
-
lysophosphocholine acyltransferase 3
-
lysophosphocholine acyltransferase 4
-
lysophospholipid acyltransferase
additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-64-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
show the reaction diagram
acyl-CoA + 1-acyl-sn-lysophosphatidylcholine
CoA + 1,2-diacyl-sn-lysophosphatidylcholine
show the reaction diagram
-
-
-
?
acyl-CoA + lysophosphatidylcholine
CoA + phosphatidylcholine
show the reaction diagram
-
-
-
?
lysophosphatidylcholine + acyl-CoA
phosphatidylcholine + CoA
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-lysophosphatidylcholine
show the reaction diagram
quantification of palmitic acid by gas chromatography
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + dipalmitoylphosphatidylcholine
show the reaction diagram
i.e. 1-palmitoyl-lysophosphatidylcholine
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
show the reaction diagram
palmitoyl-CoA + 2-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
show the reaction diagram
reaction of EC 2.3.1.62
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylcholine + CoA
show the reaction diagram
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + linolenoyl-CoA
1-palmitoyl-2-alpha-linolenoylphosphatidylcholine + CoA
show the reaction diagram
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + linoleoyl-CoA
1-palmitoyl-2-linoleoylphosphatidylcholine + CoA
show the reaction diagram
-
-
-
?
1-palmitoyl-2-lysophosphatidylcholine + oleoyl-CoA
1-palmitoyl-2-oleoylphosphatidylcholine + CoA
show the reaction diagram
-
-
-
?
1-palmitoyl-2-lysophosphatidylethanolamine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylethanolamine + CoA
show the reaction diagram
-
-
-
?
1-palmitoyl-2-lysophosphatidylserine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylserine + CoA
show the reaction diagram
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylcholine
CoA + 1,2-diacyl-lysophosphatidylcholine
show the reaction diagram
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
show the reaction diagram
acyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1,2-diacyl-sn-glycero-3-phosphoethanolamine
show the reaction diagram
-
-
-
?
acyl-CoA + 2-acyl-sn-lysophosphatidylglycerol
CoA + 1,2-diacyl-sn-lysophosphatidylglycerol
show the reaction diagram
-
-
-
?
acyl-CoA + lysophosphatidylcholine
CoA + phosphatidylcholine
show the reaction diagram
-
-
-
?
arachidonoyl-CoA + 1-acyl-lysophosphatidylcholine
CoA + 1-acyl-2-arachidonoyl-lysophosphatidylcholine
show the reaction diagram
preferred substrate
-
-
?
arachidonoyl-CoA + 1-acyl-lysophosphatidylethanolamine
CoA + 1-acyl-2-arachidonoyl-lysophosphatidylethanolamine
show the reaction diagram
-
-
-
?
arachidonoyl-CoA + 1-acyl-lysophosphatidylserine
CoA + 1-acyl-2-arachidonoyl-lysophosphatidylserine
show the reaction diagram
-
-
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
arachidonoyl-CoA + 1-stearoyl-lysophosphatidylcholine
CoA + 1-stearoyl-2-arachidonoyl-lysophosphatidylcholine
show the reaction diagram
preferred reaction
-
-
?
arachidonoyl-CoA + 2-stearoyl-lysophosphatidylcholine
CoA + 1-arachidonoyl-2-stearoyl-lysophosphatidylcholine
show the reaction diagram
low activity, cf. EC 2.3.1.62
-
-
?
docosahexaenoyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1-acyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine
show the reaction diagram
-
-
-
?
docosahexaenoyl-CoA + 1-arachidonoyl-sn-glycero-3-phosphoethanolamine
CoA + 1-arachidonoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine
show the reaction diagram
-
-
-
?
docosahexaenoyl-CoA + 1-oleoyl-sn-glycero-3-phosphoethanolamine
CoA + 1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine
show the reaction diagram
-
-
-
?
docosahexaenoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphoethanolamine
CoA + 1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine
show the reaction diagram
-
-
-
?
docosahexanoyl-CoA + 1-octadecenyl-sn-glycero-3-phosphoethanolamine
CoA + 1-octadecenyl-2-docosahexanoyl-sn-glycero-3-phosphoethanolamine
show the reaction diagram
reaction of EC 2.3.1.25
-
-
?
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
show the reaction diagram
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphoethanolamine
show the reaction diagram
-
-
-
?
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphoinositol
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphoinositol
show the reaction diagram
-
-
-
?
oleoyl-CoA + lyso-phosphatidylcholine
CoA + phosphatidylcholine
show the reaction diagram
-
-
-
-
?
oleoyl-CoA + lyso-platelet-activating factor
CoA + platelet-activating factor
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-palmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
r
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
stearoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-stearoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
r
stearoyl-CoA + 1-oleoyl-sn-lysophosphatidylglycerol
CoA + 1-oleoyl-2-stearoyl-sn-lysophosphatidylglycerol
show the reaction diagram
LYCAT introduces stearic acid predominantly at the sn-1 position of lysophosphatidylglycerol (LPG), cf. EC 2.3.1.62
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
acyl-CoA + 1-acyl-sn-lysophosphatidylcholine
CoA + 1,2-diacyl-sn-lysophosphatidylcholine
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
show the reaction diagram
dipalmitoyl-PC is biosynthesized by LPCAT1 in the Lands' cycle
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylcholine
CoA + 1,2-diacyl-lysophosphatidylcholine
show the reaction diagram
-
-
-
?
acyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1,2-diacyl-sn-glycero-3-phosphoethanolamine
show the reaction diagram
-
-
-
?
acyl-CoA + 2-acyl-sn-lysophosphatidylglycerol
CoA + 1,2-diacyl-sn-lysophosphatidylglycerol
show the reaction diagram
-
-
-
?
arachidonoyl-CoA + 1-acyl-lysophosphatidylcholine
CoA + 1-acyl-2-arachidonoyl-lysophosphatidylcholine
show the reaction diagram
preferred substrate
-
-
?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
docosahexaenoyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1-acyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine
show the reaction diagram
-
-
-
?
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphoethanolamine
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
palmitoyl-CoA
inhibition at higher concentrations of palmitoyl-CoA, possibly due to a detergent effect
Pronase
-
-
-
Trypsin
-
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
lipolysaccharide
-
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0023
1-palmitoyl-lysophosphatidylcholine
pH 7.4, 30°C, recombinant enzyme
0.003
palmitoyl-CoA
pH 7.4, 30°C, recombinant enzyme
0.107
1-acyl-sn-glycero-3-phosphocholine
-
-
0.0138
1-acyl-sn-glycero-3-phosphoinositol
-
-
0.00314 - 0.0132
docosahexanoyl-CoA
0.004 - 0.011
oleoyl-CoA
additional information
additional information
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00314 - 0.0132
docosahexanoyl-CoA
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0004
purified unphosphorylated recombinant mutant D31A enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.059
purified unphosphorylated recombinant mutant C47S enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.064
purified unphosphorylated recombinant mutant S32A enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.065
0.066
purified unphosphorylated recombinant mutant D140A enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8
assay at
7.4 - 10
recombinant enzyme
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
39
assay at
30
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
a pluripotent embryonic murine mesenchymal cell line
Manually annotated by BRENDA team
-
Ehrlich ascites
Manually annotated by BRENDA team
LPCAT4 mRNA expression is stronger in the hypertrophic than in the prehypertrophic zone of cartilage
Manually annotated by BRENDA team
anterior and posterior
Manually annotated by BRENDA team
lysophosphatidylcholine acyltransferase 4 (LPCAT4) mRNA expression and LPCAT enzymatic activity towards oleoyl-, linoleoyl-, (5Z,8Z,11Z,14Z)-eicosatetraenoyl-, and docosahexaenoyl-CoA increases in the late stage of chondrogenic differentiation, when mineralization occurs
Manually annotated by BRENDA team
low content
Manually annotated by BRENDA team
low content
Manually annotated by BRENDA team
low content
Manually annotated by BRENDA team
low content
Manually annotated by BRENDA team
low content
Manually annotated by BRENDA team
higher content
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Prdx6 is a unique LPCAT enzyme with demonstrated cytoplasmic localization
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
the enzyme belongs to the MBOAT family
malfunction
metabolism
phospholipase A2 (PLA2) plays a role in membrane phospholipid remodeling by coupling with re-acylation processes mediated by lysophospholipid acyltransferases (LPLATs) to generate sn-1/sn-2 fatty acid asymmetry of phospholipids. Lysophospholipids are acylated by LPLAT to generate phospholipids phosphatidic acid (PA), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylinositol (PI), phosphatidylglycerol (PG), and cardiolipin (CL) by LPLATs. In the Kennedy pathway, glycerol-3-phosphate (G3P) is first acylated by glycerol-phosphate acyltransferase (GPAT) to form lyso-PA (LPA), which is subsequently converted to PA by LPA-acyltransferase (LPAAT). Dipalmitoyl-PC is biosynthesized by LPCAT1 in the Lands' cycle
physiological function
evolution
malfunction
metabolism
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PCAT1_MOUSE
534
1
59744
Swiss-Prot
Mitochondrion (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
59000
x * 59000, recombinant enzyme, SDS-PAGE
60000
x * 60000, recombinant enzyme, SDS-PAGE
56100
x * 56100, calculated
58900
x * 58900, calculated
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C47S
site-directed mutagenesis, construction of mutant endothelial cells via lentivirus transfection. The C47S mutant protein does not express peroxidase activity, but both PLA2 and LPCAT activities are preserved
D140A
site-directed mutagenesis, construction of mutant endothelial cells via lentivirus transfection. The D140A mutant protein retains full peroxidase activity
D31A
site-directed mutagenesis, construction of mutant endothelial cells via lentivirus transfection, the mutant loses almost all LPCAT activity, but retains PLA2 activity
H129A
site-directed mutagenesis, mutation of a residue in AGPAT motif I (HxxxxD), the mutant shows no LPEAT activity
H26A
site-directed mutagenesis, breeding of H26A Prdx6 knock-in mutant mice, the final targeting construct is linearized, sequence verified, and electroporated into C57Bl/6J ES cells (EAP6 ES cells) for insertion of the mutant sequences into the mouse genome by homologous recombination, positive clones are used for blastocyst injection into CD-1/BALB/c mice, chimeric H26A Prdx6 mice are bred to C57Bl/6J wild-type mice and the resulting heterozygotic mice are bred to homozygosity. The H26A mutant retains the ability to reduce short chain hydroperoxides, but cannot reduce phospholipid hydroperoxides, as they do not bind to the phospholipid substrate
S32A
site-directed mutagenesis, the S32A mutant retains the ability to reduce short chain hydroperoxides, but cannot reduce phospholipid hydroperoxides, as they do not bind to the phospholipid substrate
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
copurification of His-tagged or GST-tagged enzyme with His-tagged StarD10 protein from Escherichia coli by affinity chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
gene LPCAT1, functional recombinant expression in HEK-293 cells
gene LPCAT1, recombinant expression of FLAG- and HA-tagged full-length and truncated enzyme in HEK-293 cell microsomes, recombinant coexpression of His-tagged or GST-tagged enzyme with His-tagged StarD10 protein in Escherichia coli
LPCAT, DNA and amino acid sequence determination and analysis, functional expression in COS-7 cells and HEK-293 cells
LPCAT1, DNA and amino acid sequence determination and analysis, quantitative expression analysis, expression of FLAG-tagged enzyme in CHO-K1 cells, subcellular distribution pattern analysis shows enzyme expression mainly in the endoplasmic reticulum-Golgi, but also in mitochondria, and lysosome of the transfected cells
LPCAT1, quantitative real-time PCR expression analysis
expressed in Escherichia coli
FLAG-tagged version expressed in CHO-K1 cell
FLAG-tagged version expressed in COS-7 cell
-
gene Agpat7, quantitative RT-PCR expression analysis, recombinant overexpression of FLAG-tagged mLPEAT2 in CHO cells
gene LCLAT1, recombinant expression in HEK-293 cells
gene LPCAT3, hepatic lysophosphatidylcholine acyltransferase 3 is encoded by a target gene regulated by peroxisome proliferator-activated receptor delta
gene LPCAT3, recombinant expression in HEK-293 cells
gene prdx6, functional recombinant enzyme expression in mouse pulmonary microvascular endothelial cells via infection with a lentiviral vector construct
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
hepatic LPCAT3 gene is transcriptionally regulated by peroxisome proliferator-activated receptor delta (PPARdelta). Activation of PPARdelta by agonist L165041 in mice increases hepatic LPCAT3 mRNA abundance and LPCAT enzymatic activity, which is associated with increased incorporations of arachidonate into liver phosphatidylcholine and phosphatidylethanolamine. Liver X receptor (LXR) is the important transcription factor controlling LPCAT3 expression in liver tissue via an LXR response element (LXRE) in the proximal promoter region of the murine Lpcat3 gene. The ligand-induced activation of LXR reduces hepatic inflammation and emdoplasmic reticulum stress in hyperlipidemic mice through a LPCAT3-mediated mechanism
LPCAT2 expression is increased by 16 h treatment with lipopolysaccharides
LPCAT4 mRNA expression increases during chondrogenic differentiation
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Waku, K.; Nakazawa, Y.
Regulation of the fatty acid composition of alkyl ether phospholipid in Ehrlich ascites tumor cells. The substrate specificities of 1-O-alkylglycerol 3-phosphate and 1-O-alkylglycero-3-phosphocholine acyltransferases
J. Biochem.
82
1779-1784
1977
Mus musculus
Manually annotated by BRENDA team
Wise, R.W.; Sun, G.Y.; MacQuarrie, R.
The kinetic properties of oleoyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase from mouse-brain microsomes
Eur. J. Biochem.
109
201-206
1980
Mus musculus, Mus musculus C57BL/10J
Manually annotated by BRENDA team
Renooij, W.; Snyder, F.
Transmembrane orientation of palmitoyl-CoA: lysophosphatidylcholine acyltransferase in microsomes isolated from an alveolar type II cell adenoma and rat liver
Biochim. Biophys. Acta
666
468-474
1981
Mus musculus, Mus musculus BALB/c, Rattus norvegicus
Manually annotated by BRENDA team
Nakanishi, H.; Shindou, H.; Hishikawa, D.; Harayama, T.; Ogasawara, R.; Suwabe, A.; Taguchi, R.; Shimizu, T.
Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production
J. Biol. Chem.
281
20140-20147
2006
Rattus norvegicus (Q1HAQ0), Mus musculus (Q3TFD2), Mus musculus
Manually annotated by BRENDA team
Chen, X.; Hyatt, B.A.; Mucenski, M.L.; Mason, R.J.; Shannon, J.M.
Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells
Proc. Natl. Acad. Sci. USA
103
11724-11729
2006
Rattus norvegicus (Q1HAQ0), Mus musculus (Q3TFD2), Mus musculus
Manually annotated by BRENDA team
Cheng, L.; Han, X.; Shi, Y.
A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice
Am. J. Physiol. Endocrinol. Metab.
297
E1276-E1282
2009
Mus musculus
Manually annotated by BRENDA team
Shindou, H.; Shimizu, T.
Acyl-CoA:lysophospholipid acyltransferases
J. Biol. Chem.
284
1-5
2009
Mus musculus (Q3TFD2), Mus musculus (Q8BYI6), Mus musculus (Q8R3I2), Mus musculus (Q91V01), Homo sapiens (Q6P1A2), Homo sapiens (Q6ZWT7), Homo sapiens (Q7L5N7), Homo sapiens (Q8NF37)
Manually annotated by BRENDA team
Jackson, S.K.; Abate, W.; Tonks, A.J.
Lysophospholipid acyltransferases: novel potential regulators of the inflammatory response and target for new drug discovery
Pharmacol. Ther.
119
104-114
2008
Bos taurus, Rattus norvegicus, Mus musculus (Q3TFD2), Homo sapiens (Q8NF37)
Manually annotated by BRENDA team
Hishikawa, D.; Shindou, H.; Kobayashi, S.; Nakanishi, H.; Taguchi, R.; Shimizu, T.
Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity
Proc. Natl. Acad. Sci. USA
105
2830-2835
2008
Mus musculus (A2AWA9), Mus musculus (Q91V01)
Manually annotated by BRENDA team
Soupene, E.; Fyrst, H.; Kuypers, F.
Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes
Proc. Natl. Acad. Sci. USA
105
88-93
2008
Mus musculus (Q3TFD2), Mus musculus (Q6NVG1), Mus musculus (Q8BYI6), Mus musculus
Manually annotated by BRENDA team
Morimoto, R.; Shindou, H.; Oda, Y.; Shimizu, T.
Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages
J. Biol. Chem.
285
29857-29862
2010
Mus musculus (Q8BYI6)
Manually annotated by BRENDA team
Zou, C.; Ellis, B.M.; Smith, R.M.; Chen, B.B.; Zhao, Y.; Mallampalli, R.K.
Acyl-CoA:lysophosphatidylcholine acyltransferase I (Lpcat1) catalyzes histone protein O-palmitoylation to regulate mRNA synthesis
J. Biol. Chem.
286
28019-28025
2011
Mus musculus
Manually annotated by BRENDA team
Bridges, J.P.; Ikegami, M.; Brilli, L.L.; Chen, X.; Mason, R.J.; Shannon, J.M.
LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice
J. Clin. Invest.
120
1736-1748
2010
Mus musculus (Q3TFD2), Mus musculus
Manually annotated by BRENDA team
Lin, S.; Ikegami, M.; Moon, C.; Naren, A.P.; Shannon, J.M.
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) specifically interacts with phospholipid transfer protein starD10 to facilitate surfactant phospholipid trafficking in alveolar type II cells
J. Biol. Chem.
290
18559-18574
2015
Mus musculus (Q3TFD2), Mus musculus FVB/N (Q3TFD2)
Manually annotated by BRENDA team
Eto, M.; Shindou, H.; Yamamoto, S.; Tamura-Nakano, M.; Shimizu, T.
Lysophosphatidylethanolamine acyltransferase 2 (LPEAT2) incorporates DHA into phospholipids and has possible functions for fatty acid-induced cell death
Biochem. Biophys. Res. Commun.
526
246-252
2020
Mus musculus (Q6NVG1)
Manually annotated by BRENDA team
Kawana, H.; Kano, K.; Shindou, H.; Inoue, A.; Shimizu, T.; Aoki, J.
An accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases
Biochim. Biophys. Acta
1864
1053-1060
2019
Mus musculus (Q3TFD2), Mus musculus (Q3UN02), Mus musculus (Q91V01), Homo sapiens (Q8NF37)
Manually annotated by BRENDA team
Kita, Y.; Shindou, H.; Shimizu, T.
Cytosolic phospholipase A2 and lysophospholipid acyltransferases
Biochim. Biophys. Acta
1864
838-845
2019
Mus musculus (Q3TFD2), Mus musculus (Q8BYI6), Mus musculus (Q91V01)
Manually annotated by BRENDA team
Akagi, S.; Kono, N.; Ariyama, H.; Shindou, H.; Shimizu, T.; Arai, H.
Lysophosphatidylcholine acyltransferase 1 protects against cytotoxicity induced by polyunsaturated fatty acids
FASEB J.
30
2027-2039
2016
Mus musculus (Q3TFD2), Mus musculus, Homo sapiens (Q8NF37)
Manually annotated by BRENDA team
Singh, A.B.; Liu, J.
Identification of hepatic lysophosphatidylcholine acyltransferase 3 as a novel target gene regulated by peroxisome proliferator-activated receptor delta
J. Biol. Chem.
292
884-897
2017
Homo sapiens (Q6P1A2), Mus musculus (Q91V01), Mus musculus
Manually annotated by BRENDA team
Fisher, A.B.; Dodia, C.; Sorokina, E.M.; Li, H.; Zhou, S.; Raabe, T.; Feinstein, S.I.
A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6
J. Lipid Res.
57
587-596
2016
Mus musculus (O08709), Mus musculus, Rattus norvegicus (O35244), Homo sapiens (P30041), Mus musculus C57BL/6J (O08709)
Manually annotated by BRENDA team
Shindou, H.; Shimizu, T.; Okinaga, T.; Seta, Y.; Tominaga, K.; Nishihara, T.
Lysophosphatidylcholine acyltransferase 4 is involved in chondrogenic differentiation of ATDC5 cells
Sci. Rep.
7
16701
2017
Mus musculus (Q6NVG1)
Manually annotated by BRENDA team