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Information on EC 2.3.1.23 - 1-acylglycerophosphocholine O-acyltransferase

for references in articles please use BRENDA:EC2.3.1.23
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EC Tree
IUBMB Comments
Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor.
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This record set is specific for:
UNIPROT: A2AWA9
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
pcat1, lpcat3, lpcat, lysophosphatidylcholine acyltransferase, alcat1, lpcat2, lysolecithin acyltransferase, lycat, lyso-paf acetyltransferase, lysophosphatidylcholine acyltransferase 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
lysophosphatidylcholine acyltransferase 4
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1-acyl-sn-glycero-3-phosphocholine acyltransferase
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acyl coenzyme A-monoacylphosphatidylcholine acyltransferase
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acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase
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acyltransferase, lysolecithin
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lysolecithin acyltransferase
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lysophosphatide acyltransferase
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lysophosphatidylcholine acyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-64-9
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-palmitoyl-2-lysophosphatidylcholine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylcholine + CoA
show the reaction diagram
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-
-
?
1-palmitoyl-2-lysophosphatidylcholine + oleoyl-CoA
1-palmitoyl-2-oleoylphosphatidylcholine + CoA
show the reaction diagram
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-
-
?
1-palmitoyl-2-lysophosphatidylethanolamine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylethanolamine + CoA
show the reaction diagram
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-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
RBGP1_MOUSE
1064
0
120798
Swiss-Prot
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
56100
x * 56100, calculated
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 56100, calculated
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
FLAG-tagged version expressed in CHO-K1 cell
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hishikawa, D.; Shindou, H.; Kobayashi, S.; Nakanishi, H.; Taguchi, R.; Shimizu, T.
Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity
Proc. Natl. Acad. Sci. USA
105
2830-2835
2008
Mus musculus (A2AWA9), Mus musculus (Q91V01)
Manually annotated by BRENDA team