Information on EC 2.3.1.190 - acetoin dehydrogenase

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The expected taxonomic range for this enzyme is: Bacteria, Archaea

EC NUMBER
COMMENTARY
2.3.1.190
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RECOMMENDED NAME
GeneOntology No.
acetoin dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
acetoin + CoA + NAD+ = acetaldehyde + acetyl-CoA + NADH + H+
show the reaction diagram
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PATHWAY
KEGG Link
MetaCyc Link
acetoin degradation
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:acetoin O-acetyltransferase
Requires thiamine diphosphate. This enzyme, which belongs to the family of 2-oxo acid dehydrogenase complexes, catalyses the oxidative-hydrolytic cleavage of acetoin to acetaldehyde and acetyl-CoA in many bacterial strains, both aerobic and anaerobic. The enzyme is composed of multiple copies of three enzymic components: acetoin oxidoreductase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoyl dehydrogenase (E3).
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
AcoA
Q52014
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AcoB
Q52015
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Alcaligenes eutrophus H16
subunit acoA
UniProt
Manually annotated by BRENDA team
Alcaligenes eutrophus H16
subunit acoB
UniProt
Manually annotated by BRENDA team
subunit E1alpha
UniProt
Manually annotated by BRENDA team
subunit E1beta
UniProt
Manually annotated by BRENDA team
subunit E1alpha
UniProt
Manually annotated by BRENDA team
subunit E1beta
UniProt
Manually annotated by BRENDA team
E1alpha subunit
UniProt
Manually annotated by BRENDA team
E1beta subunit
UniProt
Manually annotated by BRENDA team
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
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The combination of purified Ao:DCPIP OR, dihydrolipoamide dehydrogenase, and dihydrolipoamide acetyltransferase in the presence of thiamine diphosphate and the substrate acetoin or methylacetoin results in a coenzyme A-dependent reduction of NAD
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SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
2.15
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Alcaligenes eutrophus H16
P27745, P27746
;
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
from acetoin-grown cells; from acetoin-grown cells
Alcaligenes eutrophus H16
P27745, P27746
component E1, i.e. acetoin:2,6-dichlorophenolindophenol oxidoreductase
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from acetoin-grown cells
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EXPRESSION
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
formation of the enzyme components of the acetoin dehydrogenase enzyme system E1, i.e. acetoin:2,6-dichlorophenolindophenol oxidoreductase Ao:DCPIP OR,, E2, i.e. dihydrolipoamide acetyltransferase DHLTA, and E3, i.e. dihydrolipoamide dehydrogenase DHLDH, are induced during growth on acetoin
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the enzymes Ao:DCPIP OR, dihydrolipoamide dehydrogenase, and dihydrolipoamide acetyltransferase are induced during growth on acetoin, whereas they are absent or scarcely present in cells grown on a nonacetoinogenic substrate
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