Reference on EC 2.3.1.169 - CO-methylating acetyl-CoA synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ragsdale, S.W.; Wood, H.G.
Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis
J. Biol. Chem.
260
3970-3977
1985
Moorella thermoacetica
Grahame, D.A.
Substrate and cofactor reactivity of a carbon monoxide dehydrogenase-corrinoid enzyme complex: stepwise reduction of iron-sulfur and corrinoid centers, the corrinoid Co2+/1+ redox midpoint potential, and overall synthesis of acetyl-CoA
Biochemistry
32
10786-10793
1993
Methanosarcina barkeri
Grahame, D.A.
Catalysis of acetyl-CoA cleavage and tetrahydrosarcinapterin methylation by a carbon monoxide dehydrogenase-corrinoid enzyme complex
J. Biol. Chem.
266
22227-22233
1991
Methanosarcina barkeri
Lu, W.P.; Ragsdale, S.W.
Reductive activation of the coenzyme A/acetyl-CoA isotopic exchange reaction catalyzed by carbon monoxide dehydrogenase from Clostridium thermoaceticum and its inhibition by nitrous oxide and carbon monoxide
J. Biol. Chem.
266
3554-3564
1991
Moorella thermoacetica
Roberts, J.R.; Lu, W.P.; Ragsdale, S.W.
Acetyl-coenzyme A synthesis from methyltetrahydrofolate, CO, and coenzyme A by enzymes purified from Clostridium thermoaceticum: Attainment of in vivo rates and identification of rate-limiting steps
J. Bacteriol.
174
4667-4676
1992
Moorella thermoacetica
Menon, S.; Ragsdale, S.W.
Role of the [4Fe-4S] cluster in reductive activation of the cobalt center of the corrinoid iron-sulfur protein from Clostridium thermoaceticum during acetate biosynthesis
Biochemistry
37
5689-5698
1998
Moorella thermoacetica
Doukov, T.I.; Iverson, T.M.; Seravalli, J.; Ragsdale, S.W.; Drennan, C.L.
A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase
Science
298
567-572
2002
Moorella thermoacetica (P27989)
Lu, W.P.; Harder, S.R.; Ragsdale, S.W.
Controlled potential enzymology of methyl transfer reactions involved in acetyl-CoA synthesis by CO dehydrogenase and the corrinoid/iron-sulfur protein from Clostridium thermoaceticum
J. Biol. Chem.
265
3124-3133
1990
Moorella thermoacetica
Roberts, D.L.; James-Hagstrom, J.E.; Garvin, D.K.; Gorst, C.M.; Runquist, J.A.; Baur, J.R.; Haase, F.C.; Ragsdale, S.W.
Cloning and expression of the gene cluster encoding key proteins involved in acetyl-CoA synthesis in Clostridium thermoaceticum: carbon monoxide dehydrogenase, the corrinoid/iron-sulfur protein, and methyltransferase
Proc. Natl. Acad. Sci. USA
86
32-36
1989
Moorella thermoacetica
Jablonski, P.E.; Lu, W.P.; Ragsdale, S.W.; Ferry, J.G.
Characterization of the metal centers of the corrinoid/iron-sulfur component of the carbon monoxide dehydrogenase enzyme complex from Methanosarcina thermophila by EPR spectroscopy and spectroelectrochemistry
J. Biol. Chem.
268
325-329
1993
Methanosarcina thermophila
Kasmi, A.E.; Rajasekharan, S.; Ragsdale, S.W.
Anaerobic pathway for conversion of the methyl group of aromatic methyl ethers to acetic acid by Clostridium thermoaceticum
Biochemistry
33
11217-11224
1994
Moorella thermoacetica
Menon, S.; Ragsdale, S.W.
The role of an iron-sulfur cluster in an enzymic methylation reaction: Methylation of CO dehydrogenase/acetyl-CoA synthase by the methylated corrinoid iron-sulfur protein
J. Biol. Chem.
274
11513-11518
1999
Moorella thermoacetica
Murakami, E.; Ragsdale, S.W.
Evidence for intersubunit communication during acetyl-CoA cleavage by the multienzyme CO dehydrogenase/acetyl-CoA synthase complex from Methanosarcina thermophila. Evidence that the beta subunit catalyzes C-C and C-S bond cleavage
J. Biol. Chem.
275
4699-4707
2000
Methanosarcina thermophila (P72021), Methanosarcina thermophila, Methanosarcina thermophila TM1 (P72021)
Tan, X.S.; Sewell, C.; Lindahl, P.A.
Stopped-flow kinetics of methyl group transfer between the corrinoid-iron-sulfur protein and acetyl-Coenzyme A synthase from Clostridium thermoaceticum
J. Am. Chem. Soc.
124
6277-6284
2002
Moorella thermoacetica
Tan, X.; Sewell, C.; Yang, Q.; Lindahl, P.A.
Reduction and methyl transfer kinetics of the a subunit from acetyl Coenzyme A synthase
J. Am. Chem. Soc.
125
318-319
2003
Moorella thermoacetica
Bramlett, M.R.; Tan, X.; Lindahl, P.A.
Inactivation of acetyl-CoA synthase/carbon monoxide dehydrogenase by copper
J. Am. Chem. Soc.
125
9316-9317
2003
Moorella thermoacetica
Seravalli, J.; Brown, K.L.; Ragsdale, S.W.
Acetyl Coenzyme A synthesis from unnatural methylated corrinoids: Requirement for "Base-Off" coordination at cobalt
J. Am. Chem. Soc.
123
1786-1787
2001
Moorella thermoacetica, Methanosarcina barkeri
Tan, X.; Loke, H.K.; Fitch, S.; Lindahl, P.A.
The tunnel of acetyl-coenzyme A synthase/carbon monoxide dehydrogenase regulates delivery of CO to the active site
J. Am. Chem. Soc.
127
5833-5839
2005
Moorella thermoacetica
Golden, M.L.; Rampersad, M.V.; Reibenspies, J.H.; Darensbourg, M.Y.
Capture of NiII, CuI and ZnII by thiolate sulfurs of an N2S2Ni complex: A role for a metallothiolate ligand in the acetyl-coenzyme A synthase active site
Chem. Commun. (Camb.)
2003
1824-1825
2003
Moorella thermoacetica
-
Linck, R.C.; Spahn, C.W.; Rauchfuss, T.B.; Wilson, S.R.
Structural analogues of the bimetallic reaction center in acetyl CoA synthase: A Ni-Ni Model with bound CO
J. Am. Chem. Soc.
125
8700-8701
2003
Moorella thermoacetica
Seravalli, J.; Gu, W.; Tam, A.; Strauss, E.; Begley, T.P.; Cramer, S.P.; Ragsdale, S.W.
Functional copper at the acetyl-CoA synthase active site
Proc. Natl. Acad. Sci. USA
100
3689-3694
2003
Moorella thermoacetica
Svetlitchnyi, V.; Dobbek, H.; Meyer-Klaucke, W.; Meins, T.; Thiele, B.; Roemer, P.; Huber, R.; Meyer, O.
A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans
Proc. Natl. Acad. Sci. USA
101
446-451
2004
Carboxydothermus hydrogenoformans
Bramlett, M.R.; Stubna, A.; Tan, X.; Surovtsev, I.V.; Muenck, E.; Lindahl, P.A.
Moessbauer and EPR study of recombinant acetyl-CoA synthase from Moorella thermoacetica
Biochemistry
45
8674-8685
2006
Moorella thermoacetica
Amara, P.; Volbeda, A.; Fontecilla-Camps, J.C.; Field, M.J.
A quantum chemical study of the reaction mechanism of acetyl-coenzyme a synthase
J. Am. Chem. Soc.
127
2776-2784
2005
synthetic construct
Tan, X.; Surovtsev, I.V.; Lindahl, P.A.
Kinetics of CO insertion and acetyl group transfer steps, and a model of the acetyl-CoA synthase catalytic mechanism
J. Am. Chem. Soc.
128
12331-12338
2006
Moorella thermoacetica
Tan, X.; Volbeda, A.; Fontecilla-Camps, J.C.; Lindahl, P.A.
Function of the tunnel in acetylcoenzyme A synthase/carbon monoxide dehydrogenase
J. Biol. Inorg. Chem.
11
371-378
2006
Moorella thermoacetica
Doukov, T.I.; Blasiak, L.C.; Seravalli, J.; Ragsdale, S.W.; Drennan, C.L.
Xenon in and at the end of the tunnel of bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase
Biochemistry
47
3474-3483
2008
Moorella thermoacetica
Seravalli, J.; Ragsdale, S.W.
Pulse-chase studies of the synthesis of acetyl-CoA by carbon monoxide dehydrogenase/acetyl-CoA synthase: evidence for a random mechanism of methyl and carbonyl addition
J. Biol. Chem.
283
8384-8394
2008
Moorella thermoacetica (P27988)
Tan, X.; Lindahl, P.A.
Tunnel mutagenesis and Ni-dependent reduction and methylation of the alpha subunit of acetyl coenzyme A synthase/carbon monoxide dehydrogenase
J. Biol. Inorg. Chem.
13
771-778
2008
Moorella thermoacetica
Kung, Y.; Doukov, T.I.; Seravalli, J.; Ragsdale, S.W.; Drennan, C.L.
Crystallographic snapshots of cyanide- and water-bound C-clusters from bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase
Biochemistry
48
7432-7440
2009
Moorella thermoacetica
Volbeda, A.; Darnault, C.; Tan, X.; Lindahl, P.A.; Fontecilla-Camps, J.C.
Novel domain arrangement in the crystal structure of a truncated acetyl-CoA synthase from Moorella thermoacetica
Biochemistry
48
7916-7926
2009
Moorella thermoacetica, Moorella thermoacetica (P27988)
Ito, M.; Kotera, M.; Matsumoto, T.; Tatsumi, K.
Dinuclear nickel complexes modeling the structure and function of the acetyl CoA synthase active site
Proc. Natl. Acad. Sci. USA
106
11862-11866
2009
synthetic construct
Bender, G.; Ragsdale, S.
Evidence that ferredoxin interfaces with an internal redox shuttle in acetyl-CoA synthase during reductive activation and catalysis
Biochemistry
50
276-286
2011
Moorella thermoacetica
Matschiavelli, N.; Oelgeschlaeger, E.; Cocchiararo, B.; Finke, J.; Rother, M.
Function and regulation of isoforms of carbon monoxide dehydrogenase/acetyl coenzyme A synthase in Methanosarcina acetivorans
J. Bacteriol.
194
5377-5387
2012
Methanosarcina acetivorans
Gencic, S.; Duin, E.C.; Grahame, D.A.
Tight coupling of partial reactions in the cc from Methanosarcina thermophila: acetyl C-C bond fragmentation at the a cluster promoted by protein conformational changes
J. Biol. Chem.
285
15450-15463
2010
Carboxydothermus hydrogenoformans, Methanosarcina thermophila, Carboxydothermus hydrogenoformans DSM 6008, Methanosarcina thermophila TM-1
Grahame, D.A.
Methods for analysis of acetyl-CoA synthase applications to bacterial and archaeal systems
Methods Enzymol.
494
189-217
2011
Carboxydothermus hydrogenoformans
Zhu, X.; Li, T.; Gu, X.; Zhang, S.; Liu, Y.; Wang, Y.; Tan, X.
Structural and functional investigation into acetyl-coenzyme A synthase and methyltransferase from human pathogen Clostridium difficile
Metallomics
5
551-558
2013
Clostridioides difficile, Clostridioides difficile 630
Ali, M.; Oshiki, M.; Awata, T.; Isobe, K.; Kimura, Z.; Yoshikawa, H.; Hira, D.; Kindaichi, T.; Satoh, H.; Fujii, T.; Okabe, S.
Physiological characterization of anaerobic ammonium oxidizing bacterium 'Candidatus Jettenia caeni'
Environ. Microbiol.
17
2172-2189
2015
Candidatus Jettenia caeni (I3IP91 and I3IP90)
Chmielowska, A.; Lodowski, P.; Jaworska, M.
Redox potentials and protonation of the A-cluster from acetyl-CoA synthase. A density functional theory study
J. Phys. Chem. A
117
12484-12496
2013
Carboxydothermus hydrogenoformans (P83789)
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