The enzyme, found in both eukaryotes and in prokaryotes, is involved in degradation pathways such as fatty acid beta-oxidation. The enzyme acts on 3-oxoacyl-CoAs to produce acetyl-CoA and an acyl-CoA shortened by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site by a 3-oxoacyl-CoA, with the concomitant release of acetyl-CoA. In the second step the acyl group is transferred to CoA. Most enzymes have a broad substrate range for the 3-oxoacyl-CoA. cf. EC 2.3.1.9, acetyl-CoA C-acetyltransferase.
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:acetyl-CoA C-acyltransferase
The enzyme, found in both eukaryotes and in prokaryotes, is involved in degradation pathways such as fatty acid beta-oxidation. The enzyme acts on 3-oxoacyl-CoAs to produce acetyl-CoA and an acyl-CoA shortened by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site by a 3-oxoacyl-CoA, with the concomitant release of acetyl-CoA. In the second step the acyl group is transferred to CoA. Most enzymes have a broad substrate range for the 3-oxoacyl-CoA. cf. EC 2.3.1.9, acetyl-CoA C-acetyltransferase.
in mice deficient for isoform Thb, the degree of induction of peroxisomal beta-oxidation of palmitate mediated by Wy14,643, a synthetic compound activating nuclear hormone receptor PPARalpha, is significantly reduced in mice deficient for Thb, while mitochondrial beta-oxidation is unaltered. The thiolase step alone is responsible for the reduced peroxisomal beta-oxidation of fatty acids. Peroxisome proliferation in the liver after Wy-treatment is normal in Thb -/- mice
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
liver X Receptor LXRalpha and sterol regulatory binding protein SREBP-1c regulate hepatic Elovl5 expression. The up-regulation of Elovl5 expression by LXR agonist is likely secondary to the induction of SREBP-1c. C18-20 polyunsaturated fatty acids repress expression of SREBP-1c and Elovl5, but when combined with LXR ligand stimulation, which increases SREBP-1c mRNA and nuclear SREBP-1c, Elovl5 mRNA levels are restored to normal
Choi, S.; Pfleger, J.; Jeon, Y.; Yang, Z.; He, M.; Shin, H.; Sayed, D.; Astrof, S.; Abdellatif, M.
Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications
Biochim. Biophys. Acta
1862
194436
2019
Homo sapiens (P42765), Homo sapiens, Mus musculus (Q8BWT1), Mus musculus