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acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
-
-
-
r
decanoyl-CoA + L-carnitine
L-decanoyl-L-carnitine + CoA
-
-
-
?
3-hydroxy-3-methylglutaryl-CoA + L-carnitine
3-hydroxy-3-methylglutaryl-L-carnitine + CoA
-
-
-
-
r
3-methylglutaryl-CoA + L-carnitine
3-methylglutaryl-L-carnitine + CoA
-
little capacity to use this substrate
-
-
r
3-methylglutaryl-L-carnitine + CoA
3-methylglutaryl-CoA + L-carnitine
-
-
-
-
r
acetoacetyl-CoA + L-carnitine
acetoacetyl-L-carnitine + CoA
-
-
-
-
r
acetoacetyl-L-carnitine + CoA
acetoacetyl-CoA + L-carnitine
-
-
-
-
r
acetyl-CoA + L-carnitine
acetyl-L-carnitine + CoA
-
-
-
-
r
acetyl-CoA + L-carnitine
CoA + L-acetylcarnitine
-
low activity
-
-
?
acetyl-L-carnitine + CoA
acetyl-CoA + L-carnitine
-
-
-
-
r
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
acyl-L-carnitine + CoA
acyl-CoA + L-carnitine
-
-
-
-
r
beta-hydroxy-beta-methylglutaryl-L-carnitine + CoA
beta-hydroxy-beta-methylglutaryl-CoA + L-carnitine
-
-
-
-
r
butanoyl-CoA + L-carnitine
CoA + L-butanoylcarnitine
-
-
-
-
?
butyryl-CoA + L-carnitine
butyryl-L-carnitine + CoA
-
-
-
-
r
butyryl-L-carnitine + CoA
butyryl-CoA + L-carnitine
-
-
-
-
r
decanoyl-CoA + L-carnitine
CoA + L-decanoylcarnitine
-
best substrate
-
-
?
decanoyl-CoA + L-carnitine
L-decanoyl-L-carnitine + CoA
-
-
-
-
r
decanoyl-L-carnitine + CoA
decanoyl-CoA + L-carnitine
-
-
-
-
r
dodecanoyl-CoA + L-carnitine
CoA + L-dodecanoylcarnitine
-
-
-
-
?
dodecanoyl-CoA + L-carnitine
L-dodecanoyl-L-carnitine + CoA
-
-
-
-
r
dodecanoyl-L-carnitine + CoA
dodecanoyl-CoA + L-carnitine
-
-
-
-
r
heptanoyl-CoA + L-carnitine
L-heptanoyl-L-carnitine + CoA
-
-
-
-
r
heptanoyl-L-carnitine + CoA
heptanoyl-CoA + L-carnitine
-
-
-
-
r
hexadecanoyl-CoA + L-carnitine
CoA + L-hexadecanoylcarnitine
-
low activity
-
-
?
hexadecanoyl-CoA + L-carnitine
L-hexadecanoyl-L-carnitine + CoA
-
-
-
-
r
hexadecanoyl-L-carnitine + CoA
hexadecanoyl-CoA + L-carnitine
-
-
-
-
r
hexanoyl-CoA + L-carnitine
CoA + L-hexanoylcarnitine
L-carnitine + octanoyl-CoA
octanoyl-L-carnitine + CoA
-
-
-
-
r
L-hexanoylcarnitine + CoA
hexanoyl-CoA + L-carnitine
-
-
-
-
r
malonyl-CoA + L-carnitine
malonyl-L-carnitine + CoA
-
-
-
-
r
malonyl-L-carnitine + CoA
malonyl-CoA + L-carnitine
-
-
-
-
r
myristoyl-CoA + L-carnitine
myristoyl-L-carnitine + CoA
-
-
-
-
r
myristoyl-L-carnitine + CoA
myristoyl-CoA + L-carnitine
-
-
-
-
r
octanoyl-CoA + L-carnitine
CoA + L-octanoylcarnitine
-
-
-
-
?
octanoyl-L-carnitine + CoA
L-carnitine + octanoyl-CoA
-
-
-
-
r
palmitoyl-CoA + L-carnitine
L-palmitoyl-L-carnitine + CoA
-
-
-
-
r
palmitoyl-L-carnitine + CoA
palmitoyl-CoA + L-carnitine
-
-
-
-
r
pivaloyl-CoA + L-carnitine
L-pivaloyl-L-carnitine + CoA
-
little capacity to use this substrate
-
-
r
pivaloyl-L-carnitine + CoA
pivaloyl-CoA + L-carnitine
-
-
-
-
r
propionyl-CoA + L-carnitine
propionyl-L-carnitine + CoA
-
-
-
-
r
propionyl-L-carnitine + CoA
propionyl-CoA + L-carnitine
-
-
-
-
r
tetradecanoyl-CoA + L-carnitine
CoA + L-tetradecanoylcarnitine
-
-
-
-
?
valproyl-CoA + L-carnitine
L-valproyl-L-carnitine + CoA
-
little capacity to use this substrate
-
-
r
valproyl-L-carnitine + CoA
valproyl-CoA + L-carnitine
-
-
-
-
r
additional information
?
-
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
-
-
486290, 486291, 486292, 486293, 486294, 486295, 486296, 486297, 486298, 486299, 486300, 486301, 486304, 486308, 486309 -
-
r
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
-
gamma-trimethylamino-beta-hydroxybutyrate
-
-
r
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
-
beta-oxidation of fatty acids
-
-
r
hexanoyl-CoA + L-carnitine
CoA + L-hexanoylcarnitine
-
-
-
-
r
hexanoyl-CoA + L-carnitine
CoA + L-hexanoylcarnitine
-
best substrate
-
-
?
additional information
?
-
-
palmitoyl-CoA is no substrate
-
-
?
additional information
?
-
-
succinyl-CoA and beta-hydroxy-beta-methylglutaryl-CoA are no substrates
-
-
?
additional information
?
-
-
acyl-CoA substrate specificity is determined by Gly553
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Solberg, H.E.
Different carnitine acyltransferases in calf liver
Biochim. Biophys. Acta
280
422-433
1972
Bos taurus, Canis lupus familiaris, Columba sp., Oryctolagus cuniculus, Homo sapiens, Platyrrhini, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Solberg, H.E.
Acyl group specificity of mitochondrial pools of carnitine acyltransferases
Biochim. Biophys. Acta
360
101-112
1974
Bos taurus, Mus musculus, Rattus norvegicus, Mus musculus NMRI/Bom, Rattus norvegicus Wistar/Moell
brenda
Markwell, M.A.K.; Tolbert, N.E.; Bieber, L.L.
Comparison of the carnitine acyltransferase activities from rat liver peroxisomes and microsomes
Arch. Biochem. Biophys.
176
479-488
1976
Columba sp., Rattus norvegicus, Sus scrofa
-
brenda
Saggerson, E.D.; Carpenter, C.A.
Malonyl CoA inhibition of carnitine acyltransferase activities: effects of thiol-group reagents
FEBS Lett.
137
124-128
1982
Rattus norvegicus
brenda
Farrell, S.O.; Bieber, L.L.
Carnitine octanoyltransferase of mouse liver peroxisomes: properties and effect of hypolipidemic drugs
Arch. Biochem. Biophys.
222
123-132
1983
Bos taurus, Mus musculus, Rattus norvegicus
brenda
Farrell, S.O.; Fiol, C.J.; Reddy, J.K.; Bieber, L.L.
Properties of purified carnitine acyltransferases of mouse liver peroxisomes
J. Biol. Chem.
259
13089-13095
1984
Bos taurus, Canis lupus familiaris, Mus musculus, Rattus norvegicus
brenda
Bird, M.I.; Munday, L.A.; Saggerson, E.D.; Clark, J.B.
Carnitine acyltransferase activities in rat brain mitochondria. Bimodal distribution, kinetic constants, regulation by malonyl-CoA and developmental pattern
Biochem. J.
226
323-330
1985
Mus musculus, Rattus norvegicus, Rattus norvegicus Wistar
brenda
Healy, M.J.; Kerner, J.; Bieber, L.L.
Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase?
Biochem. J.
249
231-237
1988
Bos taurus, Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Lilly, K.; Bugaisky, G.E.; Umeda, P.K.; Bieber, L.L.
The medium-chain carnitine acyltransferase activity associated with rat liver microsomes is malonyl-CoA sensitive
Arch. Biochem. Biophys.
280
167-174
1990
Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Nic A'Bhaird, N.; Ramsay, R.R.
Malonyl-CoA inhibition of peroxisomal carnitine octanoyltransferase
Biochem. J.
286
637-640
1992
Rattus norvegicus
brenda
Chung, C.D.; Bieber, L.L.
Properties of the medium chain/long chain carnitine acyltransferase purified from rat liver microsomes
J. Biol. Chem.
268
4519-4524
1993
Rattus norvegicus
brenda
Pagot, Y.; Belin, J.M.
Involvement of carnitine acyltransferases in peroxisomal fatty acid metabolism by the yeast Pichia guilliermondii
Appl. Environ. Microbiol.
62
3864-3867
1996
Meyerozyma guilliermondii, Rattus norvegicus
brenda
Caudevilla, C.; Serra, D.; Miliar, A.; Codony, C.; Asins, G.; Bach, M.; Hegardt, F.G.
Processing of carnitine octanoyltransferase pre-mRNAs by cis and trans-splicing
Adv. Exp. Med. Biol.
466
95-102
1999
Bos taurus, Homo sapiens, Rattus norvegicus
brenda
Ferdinandusse, S.; Mulders, J.; IJlst, L.; Denis, S.; Dacremont, G.; Waterham, H.R.; Wanders, R.J.A.
Molecular cloning and expression of human carnitine octanoyltransferase: Evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids
Biochem. Biophys. Res. Commun.
263
213-218
1999
Bos taurus, Bos taurus (O19094), Homo sapiens (Q9UKG9), Homo sapiens, no activity in Saccharomyces cerevisiae, Rattus norvegicus (P11466)
brenda
Morillas, M.; Clotet, J.; Rubi, B.; Serra, D.; Arino, J.; Hegardt, F.G.; Asins, G.
Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues
Biochem. J.
351
495-502
2000
Bos taurus, no activity in Saccharomyces cerevisiae, Rattus norvegicus (P11466)
-
brenda
Hegardt, F.G.; Bach, M.; Asins, G.; Caudevilla, C.; Morillas, M.; Codony, C.; Serra, D.
Post-transcriptional regulation of rat carnitine octanoyltransferase
Biochem. Soc. Trans.
29
316-320
2001
Rattus norvegicus
brenda
Morillas, M.; Gomez-Puertas, P.; Roca, R.; Serra, D.; Asins, G.; Valencia, A.; Hegardt, F.G.
Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT). Mutation of CPT 1 histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity
J. Biol. Chem.
276
45001-45008
2001
Rattus norvegicus
brenda
Morillas, M.; Gomez-Puertas, P.; Rubi, B.; Clotet, J.; Arino, J.; Valencia, A.; Hegardt, F.G.; Serra, D.; Asins, G.
Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I. Mutational analysis of a malonyl-CoA affinity domain
J. Biol. Chem.
277
11473-11480
2002
Rattus norvegicus (P11466)
brenda
Morillas, M.; Gomez-Puertas, P.; Bentebibel, A.; Selles, E.; Casals, N.; Valencia, A.; Hegardt, F.G.; Asins, G.; Serra, D.
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition
J. Biol. Chem.
278
9058-9063
2003
Rattus norvegicus
brenda
Cordente, A.G.; Lopez-Vinas, E.; Vazquez, M.I.; Swiegers, J.H.; Pretorius, I.S.; Gomez-Puertas, P.; Hegardt, F.G.; Asins, G.; Serra, D.
Redesign of carnitine acetyltransferase specificity by protein engineering
J. Biol. Chem.
279
33899-33908
2004
Rattus norvegicus
brenda