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Information on EC 2.1.3.3 - ornithine carbamoyltransferase and Organism(s) Halobacterium salinarum and UniProt Accession Q48296

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EC Tree
IUBMB Comments
The plant enzyme also catalyses the reactions of EC 2.1.3.6 putrescine carbamoyltransferase, EC 2.7.2.2 carbamate kinase and EC 3.5.3.12 agmatine deiminase, thus acting as putrescine synthase, converting agmatine [(4-aminobutyl)guanidine] and ornithine into putrescine and citrulline, respectively.
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This record set is specific for:
Halobacterium salinarum
UNIPROT: Q48296
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The taxonomic range for the selected organisms is: Halobacterium salinarum
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
oct, ornithine transcarbamylase, ornithine carbamoyltransferase, otcase, ornithine transcarbamoylase, carbamoyltransferase, ornithine carbamyl transferase, ornithine carbamyltransferase, catabolic ornithine carbamoyltransferase, rotcase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carbamoyltransferase, ornithine
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-
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carbamylphosphate-ornithine transcarbamylase
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-
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citrulline phosphorylase
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-
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L-ornithine carbamoyltransferase
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-
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L-ornithine carbamyltransferase
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L-ornithine transcarbamylase
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-
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ornithine carbamyltransferase
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ornithine transcarbamoylase
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OTC
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carbamoyl group transfer
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-
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-
PATHWAY SOURCE
PATHWAYS
BRENDA
-
-, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
carbamoyl-phosphate:L-ornithine carbamoyltransferase
The plant enzyme also catalyses the reactions of EC 2.1.3.6 putrescine carbamoyltransferase, EC 2.7.2.2 carbamate kinase and EC 3.5.3.12 agmatine deiminase, thus acting as putrescine synthase, converting agmatine [(4-aminobutyl)guanidine] and ornithine into putrescine and citrulline, respectively.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-69-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
carbamoyl phosphate + L-ornithine
phosphate + L-citrulline
show the reaction diagram
catabolic ornithine carbamoyltransferase, catalyzes the reverse reaction, i.e. the cleavage of citrulline
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?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ADP
5 mM, 90% inhibition
AMP
5 mM, 90% inhibition
ATP
5 mM, 90% inhibition
CTP
5 mM, 90% inhibition
GTP
5 mM, 90% inhibition
phosphate
slight inhibition
UTP
5 mM, 90% inhibition
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
arginine
50 mM, 2fold activatin
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.8
30% of maximal activity at pH 7.0
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
also known as Halobacterium salinarium, catabolic ornithine carbamoyltransferase
SwissProt
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
200000
gel filtration
32000
6 * 32000, deduced from nucleotide sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexamer
6 * 32000, deduced from nucleotide sequence
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
unstable below 1 M KCl
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
25°C, high-salt solution, 1 year, no loss of activity
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
gel filtration, ammonium sulfate-mediated hydrophobic chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ruepp, A.; Mueller, H.N.; Lottspeich, F.; Soppa, J.
Catabolic ornithine transcarbamylase of Halobacterium halobium (salinarium): purification, characterization, sequence determination, and evolution
J. Bacteriol.
177
1129-1136
1995
Halobacterium salinarum (Q48296), Halobacterium salinarum
Manually annotated by BRENDA team