Reference on EC 2.1.2.3 - phosphoribosylaminoimidazolecarboxamide formyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Szabados, E.; Hindmarsh, E.J.; Phillips, L.; Duggleby, R.G.; Christopherson, R.I.
5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells: purification, pH dependence and inhibitors
Biochemistry
33
14237-14245
1994
Bacillus subtilis, Escherichia coli, Gallus sp., Homo sapiens
Rayl, E.A.; Moroson, B.A.; Beardsley, G.P.
The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping
J. Biol. Chem.
271
2225-2233
1996
BRENDA: Bacillus subtilis, Escherichia coli, Gallus sp., Homo sapiens (P31939), Homo sapiens, Salmonella enterica subsp. enterica serovar Typhimurium
Textmining: Bacteria, eukaryota
Akira, T.; Komatsu, M.; Nango, R.; Tomooka, A.; Konaka, K.; Yamauchi, M.; Kitamura, Y.; Nomura, S.; Tsukamoto, I.
Molecular cloning and expression of a rat cDNA encoding 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Gene
197
289-293
1997
Rattus, Homo sapiens
Aiba, A.; Mizobuchi, K.
Nucleotide sequence analysis of genes purH and purD involved in the de novo purine nucleotide biosynthesis of Escherichia coli
J. Biol. Chem.
264
21239-21246
1989
Escherichia coli, plasmids, Salmonella enterica subsp. enterica serovar Typhimurium
Flannigan, K.A.; Hennigan, S.H.; Vogelbacker, H.H.; Gots, J.S.; Smith, J.M.
Purine biosynthesis in Escherichia coli K12: structure and DNA sequence studies of the purHD locus
Mol. Microbiol.
4
381-392
1990
Escherichia coli, Escherichia coli K-12
Hartman, S.C.; Buchanan, J.M.
Biosynthesis of the purines. XXVI. The Identification of the formyl donors of the transformylation reactions
J. Biol. Chem.
234
1812-1816
1959
Gallus sp.
Patrick, T.W.; Crosbie, G.W.
Specificity of 4-aminoimidazole-5-carboxamide ribotide transformylase of Escherichia coli
Biochem. J.
124
31-32
1971
Escherichia coli
Iwai, K.; Fujisawa, Y.; Suzuki, N.
The accumulation of 5'-phosphoribosyl-5amino-4-imidazolecarboxamide in folate-deficient pea seedlings and the enzymatic reaction in which the compound is involved
Agric. Biol. Chem.
36
398-408
1972
Allium cepa, Columba sp., Daucus carota, Escherichia coli, Gallus sp., Petroselinum crispum, Pisum sativum, Spinacia oleracea, Trifolium sp.
-
Baggott, J.E.; Krumdieck, C.L.
Folylpoly-gamma-glutamates as cosubstrates of 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide formyltransferase
Biochemistry
18
1037-1041
1979
Gallus sp.
-
Mueller, W.T.; Benkovic, S.J.
On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver
Biochemistry
20
337-344
1981
BRENDA: Gallus sp., Mus musculus
Textmining: Gallus gallus
Smith, G.K.; Mueller, T.; Benkovic, P.A.; Benkovic, S.J.
On the cofactor specificity of glycinamide ribonucleotide and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase from chicken liver
Biochemistry
20
1241-1245
1981
BRENDA: Gallus sp.
Textmining: Gallus gallus
Baggott, J.E.; Vaughn, W.H.; Hudson, B.B.
Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide
Biochem. J.
236
193-200
1986
Gallus sp., Mus musculus
Ha, T.; Morgan, S.L.; Vaughn, W.H; Eto, I.; Baggott, J.E.
Detection of inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase by thioinosinic acid and azathioprine by a new colorimetric assay
Biochem. J.
272
339-342
1990
BRENDA: Gallus sp., Homo sapiens, Mus musculus
Textmining: Gallus gallus, animal
Boger, D.L.; Haynes, N.E.; Warren, M.S.; Gooljarsingh, L.T.; Ramcharan, J.; Kitos, P.A.; Benkovic, S.J.
Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase
Bioorg. Med. Chem.
5
1831-1838
1997
Gallus sp.
Sugita, T.; Aya, H.; Ueno, M.; Ishizuka, T.; Kawashima, K.
Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase
J. Biochem.
122
309-313
1997
BRENDA: Bacillus subtilis, Homo sapiens, Salmonella enterica subsp. enterica serovar Typhimurium
Textmining: Escherichia coli
Reyes, V.M.; Greasley, S.E.; Stura, E.A.; Beardsley, G.P.; Wilson, I.A.
Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in Escherichia coli
Acta Crystallogr. Sect. D
56
1051-1054
2000
Gallus sp.
-
Wall, M.; Shim, J.H.; Benkovic, S.J.
Human AICAR transformylase: Role of the 4-Carboxamide of AICAR in binding and catalysis
Biochemistry
39
11303-11311
2000
Escherichia coli, Homo sapiens
Shim, J.H.; Wall, M.; Benkovic, S.J.; Diaz, N.; Suarez, D.; Merz, K.M., Jr.
Evaluation of the catalytic mechanism of AICAR transformylase by pH-dependent kinetics, mutagenesis, and quantum chemical calculations
J. Am. Chem. Soc.
123
4687-4696
2001
Bacillus subtilis, Escherichia coli, Gallus sp., Homo sapiens, Salmonella enterica subsp. enterica serovar Typhimurium
Vergis, J.M.; Bulock, K.G.; Fleming, K.G.; Beardsley, G.P.
Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity
J. Biol. Chem.
276
7727-7733
2001
Saccharomyces cerevisiae, Gallus sp., Homo sapiens
Bulock, K.G.; Beardsley, G.P.; Anderson, K.S.
The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase): A surprising lack of substrate channeling
J. Biol. Chem.
277
22168-22174
2002
Gallus sp., Homo sapiens
Wolan, D.W.; Greasley, S.E.; Beardsley, G.P.; Wilson, I.A.
Structural insights into the avian AICAR transformylase mechanism
Biochemistry
41
15505-15513
2002
Gallus sp., Homo sapiens
Wolan, D.W.; Cheong, C.G.; Greasley, S.E.; Wilson, I.A.
Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor
Biochemistry
43
1171-1183
2004
Homo sapiens, Homo sapiens (P31939)
Cheong, C.G.; Wolan, D.W.; Greasley, S.E.; Horton, P.A.; Beardsley, G.P.; Wilson, I.A.
Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates
J. Biol. Chem.
279
18034-18045
2004
Homo sapiens (P31939), Homo sapiens
Wolan, D.W.; Greasley, S.E.; Wall, M.J.; Benkovic, S.J.; Wilson, I.A.
Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site
Biochemistry
42
10904-10914
2003
Gallus gallus (P31335)
Vergis, J.M.; Beardsley, G.P.
Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase
Biochemistry
43
1184-1192
2004
aves, Homo sapiens
Capps, K.J.; Humiston, J.; Dominique, R.; Hwang, I.; Boger, D.L.
Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization
Bioorg. Med. Chem. Lett.
15
2840-2844
2005
Homo sapiens
Xu, L.; Li, C.; Olson, A.J.; Wilson, I.A.
Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening
J. Biol. Chem.
279
50555-50565
2004
Gallus gallus (P31335), Homo sapiens (P31939)
Li, C.; Xu, L.; Wolan, D.W.; Wilson, I.A.; Olson, A.J.
Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors
J. Med. Chem.
47
6681-6690
2004
Homo sapiens (P31939), Homo sapiens
Marie, S.; Heron, B.; Bitoun, P.; Timmerman, T.; Van Den Berghe, G.; Vincent, M.F.
AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC
Am. J. Hum. Genet.
74
1276-1281
2004
Homo sapiens, Homo sapiens (P31939)
Cheng, H.; Hwang, I.; Chong, Y.; Tavassoli, A.; Webb, M.E.; Zhang, Y.; Wilson, I.A.; Benkovic, S.J.; Boger, D.L.
Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway
Bioorg. Med. Chem.
13
3593-3599
2005
Escherichia coli, Homo sapiens
Gellekink, H.; Blom, H.J.; den Heijer, M.
Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis
Clin. Chem. Lab. Med.
45
471-476
2007
Homo sapiens
Axelrod, H.L.; McMullan, D.; Krishna, S.S.; Miller, M.D.; Elsliger, M.; Abdubek, P.; Ambing, E.; Astakhova, T.; Carlton, D.; Chiu, H.; Clayton, T.; Duan, L.; Feuerhelm, J.; Grzechnik, S.K.; Hale, J.; Han, G.W.; Haugen, J.; Jaroszewski, L.; Jin, K.K.; Klock, H.E.; Knuth, M.W.; Koesema, E.; Morse, A.T.; Nigoghossian, E.; Okach, L.; Oommachen, S.; Paulsen, J.; Quijano, K.; Reyes, R.; Rife, C.L.; van den Bedem, H.; Weekes, D.; White, A.; Wolf, G.; Xu, Q.; Hodgson, K.O.; Wooley, J.; Deacon. A.M.; Godzik, A.; Lesley, S.A.; Wilson, I.A.
Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 ANG. resolution
Proteins Struct. Funct. Bioinform.
71
1042-1049
2008
Thermotoga maritima
Boccalatte, F.E.; Voena, C.; Riganti, C.; Bosia, A.; DAmico, L.; Riera, L.; Cheng, M.; Ruggeri, B.; Jensen, O.N.; Goss, V.L.; Lee, K.; Nardone, J.; Rush, J.; Polakiewicz, R.D.; Comb, M.J.; Chiarle, R.; Inghirami, G.
The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL
Blood
113
2776-2790
2009
Homo sapiens (P31939)
McGuire, J.J.; Haile, W.H.
Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-D,L-4-methyleneglutamic acid (CH-1504) and its analogs
Biochem. Pharmacol.
77
1161-1172
2009
Homo sapiens
Deng, Y.; Zhou, X.; Kugel Desmoulin, S.; Wu, J.; Cherian, C.; Hou, Z.; Matherly, L.H.; Gangjee, A.
Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transpo
J. Med. Chem.
52
2940-2951
2009
BRENDA: Homo sapiens
Textmining: Cricetulus griseus
Qiu, X.; Yuan, Y.; Gao, Y.
Expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of PurH from Escherichia coli
Acta Crystallogr. Sect. F
67
1590-1594
2011
BRENDA: Escherichia coli
Textmining: Bacteria, eukaryota
Baggott, J.E.; Tamura, T.
Evidence for the hypothesis that 10-formyldihydrofolate is the in vivo substrate for aminoimidazolecarboxamide ribotide transformylase
Exp. Biol. Med. (Maywood)
235
271-277
2010
BRENDA: Homo sapiens, Rattus norvegicus
Textmining: Metazoa
Le Nours, J.; Bulloch, E.M.; Zhang, Z.; Greenwood, D.R.; Middleditch, M.J.; Dickson, J.M.; Baker, E.N.
Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide
J. Biol. Chem.
286
40706-40716
2011
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Liu, Y.; Zhang, C.; Zhang, H.; Li, M.; Yuan, J.; Zhang, Y.; Zhou, J.; Guo, H.; Zhao, L.; Du, Y.; Wang, L.; Ren, L.
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidines as potential nonclassical antifolates targeting both thymidylate and purine nucleotide biosynthesis
Eur. J. Med. Chem.
93
142-155
2015
Homo sapiens
Mitchell-Ryan, S.; Wang, Y.; Raghavan, S.; Ravindra, M.P.; Hales, E.; Orr, S.; Cherian, C.; Hou, Z.; Matherly, L.H.; Gangjee, A.
Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: Implications of inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to AMPK activation and anti-tumor activity
J. Med. Chem.
56
10016-10032
2013
Homo sapiens
Wang, Y.; Mitchell-Ryan, S.; Raghavan, S.; George, C.; Orr, S.; Hou, Z.; Matherly, L.H.; Gangjee, A.
Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents
J. Med. Chem.
58
1479-1493
2015
Homo sapiens (P31939), Homo sapiens
Boutchueng-Djidjou, M.; Collard-Simard, G.; Fortier, S.; Hebert, S.S.; Kelly, I.; Landry, C.R.; Faure, R.L.
The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network
Mol. Cell. Proteomics
14
1079-1092
2015
Homo sapiens (P31939), Rattus norvegicus (Q6IN16)
Pastore, S.; Stocco, G.; Moressa, V.; Zandona, L.; Favretto, D.; Malusa, N.; Decorti, G.; Lepore, L.; Ventura, A.
5-Aminoimidazole-4-carboxamide ribonucleotide-transformylase and inosine-triphosphate-pyrophosphatase genes variants predict remission rate during methotrexate therapy in patients with juvenile idiopathic arthritis
Rheumatol. Int.
35
619-627
2015
Homo sapiens (P31939), Homo sapiens
Witkowska, D.; Cox, H.L.; Hall, T.C.; Wildsmith, G.C.; Machin, D.C.; Webb, M.E.
Analysis of substrate binding in individual active sites of bifunctional human ATIC
Biochim. Biophys. Acta
1866
254-263
2018
Homo sapiens
Davis, B.W.; Aumiller, W.M.; Hashemian, N.; An, S.; Armaou, A.; Keating, C.D.
Colocalization and sequential enzyme activity in aqueous biphasic systems experiments and modeling
Biophys. J.
109
2182-2194
2015
Homo sapiens
Liu, Y.; Li, M.; Zhang, H.; Yuan, J.; Zhang, C.; Zhang, K.; Guo, H.; Zhao, L.; Du, Y.; Wang, L.; Ren, L.
Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents
Eur. J. Med. Chem.
115
245-256
2016
Homo sapiens
Xing, R.; Zhang, H.; Yuan, J.; Zhang, K.; Li, L.; Guo, H.; Zhao, L.; Zhang, C.; Li, S.; Gao, T.; Liu, Y.; Wang, L.
Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase
Eur. J. Med. Chem.
139
531-541
2017
Homo sapiens
Verma, P.; Kar, B.; Varshney, R.; Roy, P.; Sharma, A.
Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis
FEBS J.
284
4233-4261
2017
Staphylococcus lugdunensis, Staphylococcus lugdunensis (A0A133Q8U5)
Markandeyan, D.; Kannaiyan, S.; Suresh, S.; Nimmakayala, R.; Ilamurugan, R.; Santhalingam, K.; Paul, B.
Virtual screening of phytochemicals for methotrexate like dihydrofolate reductase and aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase inhibitory property using Molegro virtual docker
Int. J. Pharm. Pharm. Sci.
8
83-87
2016
Homo sapiens (P31939)
-
Riedinger, C.; Mendler, M.; Schlotterer, A.; Fleming, T.; Okun, J.; Hammes, H.P.; Herzig, S.; Nawroth, P.P.
High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans
J. Biol. Chem.
293
4845-4859
2018
Caenorhabditis elegans, Caenorhabditis elegans (Q95QQ4)
Fales, K.R.; Njoroge, F.G.; Brooks, H.B.; Thibodeaux, S.; Torrado, A.; Si, C.; Toth, J.L.; Mc Cowan, J.R.; Roth, K.D.; Thrasher, K.J.; Frimpong, K.; Lee, M.R.; Dally, R.D.; Shepherd, T.A.; Durham, T.B.; Margolis, B.J.; Wu, Z.; Wang, Y.; Atwell, S.; Wang, J.; Hui, Y.H.; Meier, T.I.; Konicek, S.A.; Geeganage, S.
Discovery of N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a potent and selective nonclassical antifolate aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT) inhibitor
J. Med. Chem.
60
9599-9616
2017
BRENDA: Homo sapiens (P31939)
Textmining: Mus musculus
Sah, S.; Shah, R.; Govindan, A.; Varada, R.; Rex, K.; Varshney, U.
Utilisation of 10-formyldihydrofolate as substrate by dihydrofolate reductase (DHFR) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) tranformylase/IMP cyclohydrolase (PurH) in Escherichia coli
Microbiology
164
982-991
2018
Escherichia coli, Escherichia coli (P15639), Escherichia coli K12 (P15639)
Boutchueng-Djidjou, M.; Collard-Simard, G.; Fortier, S.; Hebert, S.; Kelly, I.; Landry, C.; Faure, R.
The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network
Mol. Cell. Proteomics
14
1079-1092
2015
Rattus norvegicus (O35567)
Mairinger, F; Vollbrecht, C; Halbwedl, I; Hatz, M; Stacher, E; Gülly, C; Quehenberger, F; Stephan-Falkenau, S; Kollmeier, J; Roth, A; Mairinger, T; Popper, H
Reduced Folate Carrier and Folylpolyglutamate Synthetase, but not Thymidylate Synthase Predict Survival in Pemetrexed-Treated Patients Suffering from Malignant Pleural Mesothelioma.
J Thorac Oncol
2013
Homo sapiens
Reyes, VM; Greasley, SE; Stura, EA; Beardsley, GP; Wilson, IA
Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in Escherichia coli.
Acta Crystallogr D Biol Crystallogr
56 ( Pt 8)
1051-4
2000
Escherichia coli
Thorndike, J; Gaumont, Y; Kisliuk, RL; Sirotnak, FM; Murthy, BR; Nair, MG; Piper, JR
Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.
Cancer Res
49
158-63
1989
Homo sapiens, Mus musculus
Marsilje, TH; Labroli, MA; Hedrick, MP; Jin, Q; Desharnais, J; Baker, SJ; Gooljarsingh, LT; Ramcharan, J; Tavassoli, A; Zhang, Y; Wilson, IA; Beardsley, GP; Benkovic, SJ; Boger, DL
10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
Bioorg Med Chem
10
2739-49
2002
Homo sapiens, Escherichia coli
Wallace-Povirk, A; Tong, N; Wong-Roushar, J; O'Connor, C; Zhou, X; Hou, Z; Bao, X; Garcia, GE; Li, J; Kim, S; Dann, CE; Matherly, LH; Gangjee, A
Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.
Bioorg Med Chem
37
116093
2021
Homo sapiens
Ayusawa, D; Yamauchi, M; Shimizu, K; Seno, T; Matsuhashi, M
Two types of mouse FM3A cell mutants deficient in 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and their transformants isolated by human chromosome-mediated gene transfer.
Adv Exp Med Biol
253A
537-42
1989
Homo sapiens, Mus musculus
Yamauchi, M; Ayusawa, D; Shimizu, K; Seno, T; Matsuhashi, M
Two types of mouse FM3A cell mutants deficient in 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and their transformants isolated by human chromosome-mediated gene transfer.
Somat Cell Mol Genet
15
39-48
1989
Homo sapiens, Mus musculus
Mueller, WT; Smith, GK; Benkovic, SJ; Hynes, JB
Inhibition of chicken liver 5-aminoimidazole-4-carboxamide ribonucleotide transformylase by 5,8-dideaza analogues of folic acid.
Biochem Pharmacol
37
449-51
1988
Gallus gallus
White, RH
Occurrence and biosynthesis of 5-aminoimidazole-4-carboxamide ribonucleotide and N-(beta-D-ribofuranosyl)formamide 5'-phosphate in Methanobacterium thermoautotrophicum delta(H).
J Bacteriol
179
563-6
1997
Methanothermobacter thermautotrophicus, Archaea
Tibbetts, AS; Appling, DR
Saccharomyces cerevisiae expresses two genes encoding isozymes of 5-aminoimidazole-4-carboxamide ribonucleotide transformylase.
Arch Biochem Biophys
340
195-200
1997
Gallus gallus, Homo sapiens, Saccharomyces cerevisiae
Soberón, M; Lopez, O; Miranda, J; Tabche, ML; Morera, C
Genetic evidence for 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) as a negative effector of cytochrome terminal oxidase cbb3 production in Rhizobium etli.
Mol Gen Genet
254
665-73
1997
Rhizobium etli
Tibbetts, AS; Appling, DR
Characterization of two 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase isozymes from Saccharomyces cerevisiae.
J Biol Chem
275
20920-7
2000
Saccharomyces cerevisiae
Brooks, HB; Meier, TI; Geeganage, S; Fales, KR; Thrasher, KJ; Konicek, SA; Spencer, CD; Thibodeaux, S; Foreman, RT; Hui, YH; Roth, KD; Qian, YW; Wang, T; Luo, S; Torrado, A; Si, C; Toth, JL; Mc Cowan, JR; Frimpong, K; Lee, MR; Dally, RD; Shepherd, TA; Durham, TB; Wang, Y; Wu, Z; Iversen, PW; Njoroge, FG
Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Sci Rep
8
15458
2018
Mus musculus
Gao, J; Xiong, R; Xiong, D; Zhao, W; Zhang, S; Yin, T; Zhang, X; Jiang, G; Yin, Z
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
Med Sci Monit
24
8533-8543
2018
Mus musculus
Dai, SN; Hou, AJ; Zhao, SM; Chen, XM; Huang, HT; Chen, BH; Kong, HL
Ginsenoside Rb1 Ameliorates Autophagy of Hypoxia Cardiomyocytes from Neonatal Rats via AMP-Activated Protein Kinase Pathway.
Chin J Integr Med
2018
Rattus
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Homo sapiens
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Bos taurus
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Mus sp.
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The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose Transport.
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Mus musculus
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