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Reference on EC 2.1.2.2 - phosphoribosylglycinamide formyltransferase 1

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Daubner, S.C.; Schrimsher, J.L.; Schendel, F.J.; Young, M.; Henikoff, S.; Patterson, D.; Stubbe, J.; Benkovic, S.J.
A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis
Biochemistry
24
7059-7062
1985
Saccharomyces cerevisiae, Gallus gallus, Drosophila melanogaster, Schizosaccharomyces pombe
Manually annotated by BRENDA team
Caperelli, C.A.; Liu, D.
Carbocyclic substrates for de novo purine biosynthesis. Enantiospecific synthesis and enantiospecificity of enzymatic utilization
J. Biol. Chem.
267
9783-9787
1992
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Caperelli, C.A.; Benkovic, P.A.; Chettur, G.; Benkovic, S.J
Purification of a complex catalizing folate cofactor synthesis and transformylation in de novo purine biosynthesis
J. Biol. Chem.
255
1885-1890
1980
Saccharomyces cerevisiae, Gallus gallus, Columba sp., Oryctolagus cuniculus, Ovis aries, Sus scrofa
Manually annotated by BRENDA team
Hards, R.G.; Graw, S.L.; Patterson, D.
Purification of mammalian glycinamide ribonucleotide (GAR) synthetase
Adv. Exp. Med. Biol.
195
315-319
1986
Rattus norvegicus
-
Manually annotated by BRENDA team
Caperelli, C.A.; Chettur, G.; Lin-Kosley, L.
Purification of glycineamide ribonucleotide transformylase
Dev. Biochem.
4
371-376
1979
Gallus gallus
-
Manually annotated by BRENDA team
Warren, L.; Buchanan, J.M.
Biosynthesis of the purines. XIX. 2-Amino-N-ribosylacetamide 5'-phosphate(glycinamide ribotide) transformylase
J. Biol. Chem.
229
613-626
1957
Gallus gallus, Clostridium cylindrosporum, Columba sp.
Manually annotated by BRENDA team
Smith, G.K.; Benkovic, P.A.; Benkovic, S.J.
L(-)-10-formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver
Biochemistry
20
4034-4036
1981
Gallus gallus, Escherichia coli
Manually annotated by BRENDA team
Chen, P.; Schulze-Gahmen, U.; Stura, E.A.; Inglese, J.; Johnson, D.L.; Marolewski, A.; Benkovic, S.J.; Wilson, I.A.
Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution
J. Mol. Biol.
227
283-292
1992
Bacillus subtilis, Saccharomyces cerevisiae, Drosophila melanogaster, Escherichia coli, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Caperelli, C.A.; Chettur, G.; Lin, L.Y.; Benkovic, S.J.
Purification of glycineamide ribonucleotide transformylase
Biochem. Biophys. Res. Commun.
82
403-410
1978
Saccharomyces cerevisiae, Gallus gallus, Ovis aries, Sus scrofa
Manually annotated by BRENDA team
Caperelli, C.A.; Price, M.F.
Carbocyclic glycinamide ribonucleotide is a substrate for glycinamide ribonucleotide transformylase
Arch. Biochem. Biophys.
264
340-342
1988
Mus musculus
Manually annotated by BRENDA team
Inglese, J.; Johnson, D.L.; Shiau, A.; Smith, J.M.; Benkovic, S.J.
Subcloning, characterization, and affinity labeling of Escherichia coli glycinamide ribonucleotide transformylase
Biochemistry
29
1436-1443
1990
Bacillus subtilis, Cricetulus griseus, Drosophila melanogaster, Escherichia coli, Gallus gallus, Homo sapiens, Mus musculus, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Almassy, R.J.; Janson, C.A.; Kann, C.C.; Hostomska, Z.
Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase
Proc. Natl. Acad. Sci. USA
89
6114-6118
1992
Escherichia coli, Mus musculus
Manually annotated by BRENDA team
Stura, E.A.; Johnson, D.L; Inglese, J.; Smith, J.M.; Benkovic, S.J.; Wilson, I.A.
Preliminary crystallographic investigations of glycinamide ribonucleotide transformylase
J. Biol. Chem.
264
9703-9706
1989
Escherichia coli
Manually annotated by BRENDA team
Young, M.; Sammons, R.D.; Mueller, W.T.; Benkovic, S.J.
An antibody probe to determine the native species of glycinamide ribonucleotide transformylase in chicken liver
Biochemistry
23
3979-3986
1984
Gallus gallus, Mus musculus
Manually annotated by BRENDA team
Caperelli, C.A.
Mammalian glycinamide ribonucleotide transformylase: Purification and some properties
Biochemistry
24
1316-1320
1985
Gallus gallus, Mus musculus
Manually annotated by BRENDA team
Caperelli, C.A.
Mammalian glycinamide ribonucleotide transformylase. Kinetic mechanism and associated de novo purine biosynthesis activities
J. Biol. Chem.
264
5053-5057
1989
Gallus gallus, Drosophila melanogaster, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Dev, I.K.; Harvey, R.J.
N10-Formyltetrahydrofolate is the formyl donor for glycinamide ribonucleotide transformylase in Escherichia coli
J. Biol. Chem.
253
4242-4244
1978
Escherichia coli, Escherichia coli B / ATCC 11303, Gallus gallus, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Smith, G.K.; Mueller, W.T.; Wasserman, G.F.; Taylor, W.D.; Benkovic, S.J.
Characterization of the enzyme complex involving the folate-requiring enzymes of de novo purine biosynthesis
Biochemistry
19
4313-4321
1980
Gallus gallus, Escherichia coli
Manually annotated by BRENDA team
Warren, M.S.; Marolewski, A.E.; Benkovic, S.J.
A rapid screen of active site mutants in glycinamide ribonucleotide transformylase
Biochemistry
35
8855-8862
1996
Bacillus subtilis, Saccharomyces cerevisiae, Gallus gallus, Drosophila melanogaster, Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Liu, C.; Shim, J.H.; Benkovic, S.J.
The unexpected catalytic properties of a heterodimer of GAR transformylase
Bioorg. Chem.
28
316-323
2000
Escherichia coli
Manually annotated by BRENDA team
Sanghani, S.P.; Moran, R.G.
Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase
Biochemistry
36
10506-10516
1997
Gallus gallus, Escherichia coli, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Marolewski, A.; Smith, J.M.; Benkovic, S.J.
Cloning and characterization of a new purine biosynthetic enzyme: a non-folate glycinamide ribonucleotide transformylase from E. coli
Biochemistry
33
2531-2537
1994
Escherichia coli, Escherichia coli TX635
Manually annotated by BRENDA team
Nixon, A.E.; Benkovic, S.J.
Improvement in the efficiency of formyl transfer of a GAR transformylase hybrid enzyme
Protein Eng.
13
323-327
2000
Escherichia coli
Manually annotated by BRENDA team
Caperelli, C.A.; Giroux, E.L.
The human glycinamide ribonucleotide transformylase domain: purification, characterization, and kinetic mechanism
Arch. Biochem. Biophys.
341
98-103
1997
Bacillus subtilis, Saccharomyces cerevisiae, Gallus gallus, Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Antle, V.D.; Donat, N.; Hua, M.; Liao, P.L.; Vince, R.; Caperelli, C.A.
Substrate specificity of human glycinamide ribonucleotide transformylase
Arch. Biochem. Biophys.
370
231-235
1999
Gallus gallus, Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
McMorran, B.J.; Kumara, H.M.C.S.; Sullivan, K.; Lamont, I.L.
Involvement of a transformylase enzyme in siderophore synthesis in Pseudomonas aeruginosa
Microbiology
147
1517-1524
2001
Arabidopsis thaliana, Bacillus subtilis, Saccharomyces cerevisiae, Drosophila melanogaster, Escherichia coli, Pseudomonas aeruginosa
Manually annotated by BRENDA team
Habeck, L.L.; Leitner, T.A.; Shackelford, K.A.; Gossett, L.S.; Schultz, R.M.; Andis, S.L.; Shih, C.; Grindey, G.B.; Mendelsohn, L.G.
A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors
Cancer Res.
54
1021-1026
1994
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Antle, V.D.; Liu, D.; McKellar, B.R.; Caperelli, C.A.; Hua, M.; Vince, R.
Substrate specificity of glycinamide ribonucleotide transformylase from chicken liver
J. Biol. Chem.
271
6045-6049
1996
Gallus gallus, Escherichia coli
Manually annotated by BRENDA team
Shim, J.H.; Benkovic, S.J.
Evaluation of the kinetic mechanism of Escherichia coli glycinamide ribonucleotide transformylase
Biochemistry
37
8776-8782
1998
Escherichia coli, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Gooljarsingh, L.T.; Ramcharan, J.; Gilroy, S.; Benkovic, S.J.
Localization of GAR transformylase in Escherichia coli and mammalian cells
Proc. Natl. Acad. Sci. USA
98
6565-6570
2001
Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Shim, J.H.; Benkovic, S.J.
Evaluation of the kinetic mechanism of Escherichia coli glycinamide ribonucleotide transformylase probed by site-directed mutagenesis and pH-dependent studies
Biochemistry
38
10024-10031
1999
Escherichia coli
Manually annotated by BRENDA team
Hartman, S.C.; Buchanan, J.M.
Biosynthesis of the purines. XXVI. The Identification of the formyl donors of the transformylation reactions
J. Biol. Chem.
234
1812-1816
1959
Gallus gallus
Manually annotated by BRENDA team
Zhang, Y.; Desharnais, J.; Marsilje, T.H.; Li, C.; Hedrick, M.P.; Gooljarsingh, L.T.; Tavassoli, A.; Benkovic, S.J.; Olson, A.J.; Boger, D.L.; Wilson, I.A.
Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
Biochemistry
42
6043-6056
2003
Homo sapiens (P22102), Homo sapiens
Manually annotated by BRENDA team
Shi, C.; Chen, V.J.; et.al.
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
Cancer Res.
57
1116-1123
1997
Homo sapiens
Manually annotated by BRENDA team
Lee, S.G.; Lutz, S.; Benkovic, S.J.
On the structural and functional modularity of glycinamide ribonucleotide formyltransferases
Protein Sci.
12
2206-2214
2003
Homo sapiens
Manually annotated by BRENDA team
Cheng, H.; Chong, Y.; Hwang, I.; Tavassoli, A.; Zhang, Y.; Wilson, I.A.; Benkovic, S.J.; Boger, D.L.
Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway
Bioorg. Med. Chem.
13
3577-3585
2005
Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Chong, Y.; Hwang, I.; Tavassoli, A.; Zhang, Y.; Wilson, I.A.; Benkovic, S.J.; Boger, D.L.
Synthesis and biological evaluation of alpha- and gamma-carboxamide derivatives of 10-CF3CO-DDACTHF
Bioorg. Med. Chem.
13
3587-3592
2005
Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Cheng, H.; Hwang, I.; Chong, Y.; Tavassoli, A.; Webb, M.E.; Zhang, Y.; Wilson, I.A.; Benkovic, S.J.; Boger, D.L.
Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway
Bioorg. Med. Chem.
13
3593-3599
2005
Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Woehlke, A.; Droegemueller, C.; Kuiper, H.; Leeb, T.; Distl, O.
Molecular characterization and chromosomal assignment of the bovine glycinamide ribonucleotide formyltransferase (GART) gene on cattle chromosome 1q12.1-q12.2
Gene
348
73-81
2005
Bos taurus (Q599X3), Bos taurus (Q599X4), Bos taurus (Q599X5), Bos taurus
Manually annotated by BRENDA team
Manieri, W.; Moore, M.E.; Soellner, M.B.; Tsang, P.; Caperelli, C.A.
Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes
Biochemistry
46
156-163
2007
Homo sapiens
Manually annotated by BRENDA team
Deng, Y.; Wang, Y.; Cherian, C.; Hou, Z.; Buck, S.A.; Matherly, L.H.; Gangjee, A.
Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity
J. Med. Chem.
51
5052-5063
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
DeMartino, J.K.; Hwang, I.; Connelly, S.; Wilson, I.A.; Boger, D.L.
Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase
J. Med. Chem.
51
5441-5448
2008
Homo sapiens
Manually annotated by BRENDA team
Liang, Y.H.; Liu, X.Y.; Wang, J.; Li, L.F.
Protein preparation, crystallization and preliminary crystallographic studies of Bacillus subtilis glycinamide ribonucleotide transformylase
Acta Crystallogr. Sect. F
65
709-711
2009
Bacillus subtilis (P12040), Bacillus subtilis
Manually annotated by BRENDA team
McGuire, J.J.; Haile, W.H.
Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-D,L-4-methyleneglutamic acid (CH-1504) and its analogs
Biochem. Pharmacol.
77
1161-1172
2009
Homo sapiens
Manually annotated by BRENDA team
Deng, Y.; Zhou, X.; Kugel Desmoulin, S.; Wu, J.; Cherian, C.; Hou, Z.; Matherly, L.H.; Gangjee, A.
Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transpo
J. Med. Chem.
52
2940-2951
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Zhang, Z.; Caradoc-Davies, T.T.; Dickson, J.M.; Baker, E.N.; Squire, C.J.
Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery
J. Mol. Biol.
389
722-733
2009
Mycobacterium tuberculosis (P9WHM5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WHM5)
Manually annotated by BRENDA team
Zhai, F.; Liu, X.; Ruan, J.; Li, J.; Liu, Z.; Hu, Y.; Li, S.
Expression, crystallization and preliminary X-ray analysis of the phosphoribosylglycinamide formyltransferase from Streptococcus mutans
Acta Crystallogr. Sect. F
67
287-290
2011
Streptococcus mutans
Manually annotated by BRENDA team
Connelly, S.; DeMartino, J.K.; Boger, D.L.; Wilson, I.A.
Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase
Biochemistry
52
5133-5144
2013
Homo sapiens (P22102), Homo sapiens
Manually annotated by BRENDA team
Liu, Y.; Zhang, C.; Zhang, H.; Li, M.; Yuan, J.; Zhang, Y.; Zhou, J.; Guo, H.; Zhao, L.; Du, Y.; Wang, L.; Ren, L.
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidines as potential nonclassical antifolates targeting both thymidylate and purine nucleotide biosynthesis
Eur. J. Med. Chem.
93
142-155
2015
Homo sapiens (P22102)
Manually annotated by BRENDA team
Cong, X.; Lu, C.; Huang, X.; Yang, D.; Cui, X.; Cai, J.; Lv, L.; He, S.; Zhang, Y.; Ni, R.
Increased expression of glycinamide ribonucleotide transformylase is associated with a poor prognosis in hepatocellular carcinoma, and it promotes liver cancer cell proliferation
Hum. Pathol.
45
1370-1378
2014
Homo sapiens (P22102), Homo sapiens
Manually annotated by BRENDA team
Mitchell-Ryan, S.; Wang, Y.; Raghavan, S.; Ravindra, M.P.; Hales, E.; Orr, S.; Cherian, C.; Hou, Z.; Matherly, L.H.; Gangjee, A.
Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: Implications of inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to AMPK activation and anti-tumor activity
J. Med. Chem.
56
10016-10032
2013
Homo sapiens (P22102), Homo sapiens
Manually annotated by BRENDA team
Wang, Y.; Cherian, C.; Orr, S.; Mitchell-Ryan, S.; Hou, Z.; Raghavan, S.; Matherly, L.H.; Gangjee, A.
Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor alpha and inhibition of de novo purine nucleotide biosynthesis
J. Med. Chem.
56
8684-8695
2013
Homo sapiens (P22102), Homo sapiens
Manually annotated by BRENDA team
Wang, Y.; Mitchell-Ryan, S.; Raghavan, S.; George, C.; Orr, S.; Hou, Z.; Matherly, L.H.; Gangjee, A.
Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents
J. Med. Chem.
58
1479-1493
2015
Homo sapiens (P22102), Homo sapiens
Manually annotated by BRENDA team
Liu, X.; Ding, Z.; Liu, Y.; Zhang, J.; Liu, F.; Wang, X.; He, X.; Cui, G.; Wang, D.
Glycinamide ribonucleotide formyl transferase is frequently overexpressed in glioma and critically regulates the proliferation of glioma cells
Pathol. Res. Pract.
210
256-263
2014
Homo sapiens (P22102)
Manually annotated by BRENDA team
Liu, X.; Ding, Z.; Liu, Y.; Zhang, J.; Liu, F.; Wang, X.; He, X.; Cui, G.; Wang, D.
Glycinamide ribonucleotide formyl transferase is frequently overexpressed in glioma and critically regulates the proliferation of glioma cells
Pathol. Res. Pract.
210
256-263
2014
Homo sapiens (P22102)
Manually annotated by BRENDA team
Deis, S.M.; Doshi, A.; Hou, Z.; Matherly, L.H.; Gangjee, A.; Dann, C.E.
Structural and enzymatic analysis of tumor-targeted antifolates that inhibit glycinamide ribonucleotide formyltransferase
Biochemistry
55
4574-4582
2016
Homo sapiens
Manually annotated by BRENDA team
Xing, R.; Zhang, H.; Yuan, J.; Zhang, K.; Li, L.; Guo, H.; Zhao, L.; Zhang, C.; Li, S.; Gao, T.; Liu, Y.; Wang, L.
Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase
Eur. J. Med. Chem.
139
531-541
2017
Homo sapiens
Manually annotated by BRENDA team
Xu, L.; Wang, L.; Wang, J.; Zhu, Z.; Chang, G.; Guo, Y.; Tian, X.; Niu, B.
The effect of inhibiting glycinamide ribonucleotide formyl transferase on the development of neural tube in mice
Nutr. Metab.
13
56
2016
Mus musculus
Manually annotated by BRENDA team
Batool, S.; Nawaz, M.S.; Mushtaq, G.; Parvaiz, F.; Kamal, M.A.
In silico analysis of glycinamide ribonucleotide transformylase inhibition by PY873, PY899 and DIA
Saudi J. Biol. Sci.
24
1155-1161
2017
Homo sapiens (P22102), Homo sapiens
Manually annotated by BRENDA team