Information on EC 2.1.1.96 - thioether S-methyltransferase

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The expected taxonomic range for this enzyme is: Mus musculus

EC NUMBER
COMMENTARY
2.1.1.96
-
RECOMMENDED NAME
GeneOntology No.
thioether S-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
methyl group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Selenocompound metabolism
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase
Also acts on dimethyl selenide, dimethyl telluride, diethyl sulfide, 1,4-dithiane and many other thioethers.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
S-adenosyl-L-methionine:thioether S-methyltransferase
-
-
-
-
Temt
-
-
thioether methyltransferase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
114797-02-3
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
male C57BL/6J and BALB/cByJ mice, mice infected with influenza virus for experiments, enzyme mRNA levels in influenza infected mice are different from healthy mice
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 1,4-dithiane
S-adenosyl-L-homocysteine + methyl-1,4-dithiane
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 2-methylthioethanol
S-adenosyl-L-homocysteine + 2,2-dimethylthioethanol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 2-methylthioethylamine
S-adenosyl-L-homocysteine + 2,2-dimethylthioethylamine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3-methylthiopropionaldehyde
S-adenosyl-L-homocysteine + 3,3-dimethylthiopropionaldehyde
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + benzyl methyl sulfide
S-adenosyl-L-homocysteine + benzyl dimethyl sulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + diethyl sulfide
S-adenosyl-L-homocysteine + diethylmethylsulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + dimethyl selenide
S-adenosyl-L-homocysteine + trimethylselenonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + dimethyl sulfide
S-adenosyl-L-homocysteine + trimethylsulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + dimethyl telluride
S-adenosyl-L-homocysteine + trimethyltelluronium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + ethyl vinyl sulfide
S-adenosyl-L-homocysteine + methyl ethyl vinyl sulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + ethyl vinyl sulfide
S-adenosyl-L-homocysteine + methyl ethyl vinyl sulfonium
show the reaction diagram
-
suicide substrate leading to inactivation
-
-
S-adenosyl-L-methionine + methyl n-propyl sulfide
S-adenosyl-L-homocysteine + dimethyl n-propyl sulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + pentamethylene sulfide
S-adenosyl-L-homocysteine + pentamethylenemethylsulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + selenium
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + sulfur
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + tellurium
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + tetrahydrothiophene
S-adenosyl-L-homocysteine + methyltetrahydrothiophene
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + thiomorpholine
S-adenosyl-L-homocysteine + methylthiomorpholine
show the reaction diagram
-
-
-
?
additional information
?
-
-
strain- and infection-related alterations in sleep may be influenced by Temt expression and perhaps by subsequent effects on prostaglandin metabolism, mice treated with the Temt-inhibitor sinefungin develop enhanced sleep
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-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + selenium
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + sulfur
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + tellurium
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
strain- and infection-related alterations in sleep may be influenced by Temt expression and perhaps by subsequent effects on prostaglandin metabolism, mice treated with the Temt-inhibitor sinefungin develop enhanced sleep
-
-
-
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
ethyl vinyl sulfide
-
suicide substrate, inactivation rate constant: 0.05/min, dimethyl sulfide protects
methyl ethyl vinyl sulfonium
-
product of ethyl vinyl sulfide methylation inactivates
S-adenosyl-L-homocysteine
-
0.04 mM, 50% inhibition
Sinefungin
-
0.025 mM, 50% inhibition
Sinefungin
-
-
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.0004
-
dimethyl selenide
-
-
0.001
-
Dimethyl sulfide
-
-
0.001
-
S-adenosylmethionine
-
-
Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.275
-
ethyl vinyl sulfide
-
suicide substrate
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.3
-
-
sharp drop in activity below
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
28000
-
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
monomer
-
1 * 28000, SDS-PAGE
monomer
-, P40936
1 * 29460, deduced from nucleotide sequence
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
DEAE, gel filtration, chromatofocusing
-
Cloned/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
cloning of cDNA
-, P40936
EXPRESSION
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
upon exposure of pregnant mice to sodium arsenate in drinking water and subsequent injection of offspring on postpartum days 1-5 with diethylstilbestrol, transcripts for homocysteine cycling genes betaine-homocysteine methyltransferase and thioether S-methyltransferase and developmental marker genes alpha-fetoprotein, insulin-like growth factor 2 and IGF binding protein-1 are higher than with either treatment alone
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APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
medicine
-
exposure of the mouse to arsenic during a critical period of fetal development may potentially alter adrenal genetic programming, leading to endocrine disruption and potentially enhancing tumor formation together with diethylstilbestrol at other sites much later in life