Information on EC 2.1.1.96 - thioether S-methyltransferase

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The expected taxonomic range for this enzyme is: Mus musculus

EC NUMBER
COMMENTARY hide
2.1.1.96
-
RECOMMENDED NAME
GeneOntology No.
thioether S-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Selenocompound metabolism
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-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase
Also acts on dimethyl selenide, dimethyl telluride, diethyl sulfide, 1,4-dithiane and many other thioethers.
CAS REGISTRY NUMBER
COMMENTARY hide
114797-02-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 1,4-dithiane
S-adenosyl-L-homocysteine + methyl-1,4-dithiane
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 2-methylthioethanol
S-adenosyl-L-homocysteine + 2,2-dimethylthioethanol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 2-methylthioethylamine
S-adenosyl-L-homocysteine + 2,2-dimethylthioethylamine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3-methylthiopropionaldehyde
S-adenosyl-L-homocysteine + 3,3-dimethylthiopropionaldehyde
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + benzyl methyl sulfide
S-adenosyl-L-homocysteine + benzyl dimethyl sulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + diethyl sulfide
S-adenosyl-L-homocysteine + diethylmethylsulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + dimethyl selenide
S-adenosyl-L-homocysteine + trimethylselenonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + dimethyl sulfide
S-adenosyl-L-homocysteine + trimethylsulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + dimethyl telluride
S-adenosyl-L-homocysteine + trimethyltelluronium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + ethyl vinyl sulfide
S-adenosyl-L-homocysteine + methyl ethyl vinyl sulfonium
show the reaction diagram
S-adenosyl-L-methionine + methyl n-propyl sulfide
S-adenosyl-L-homocysteine + dimethyl n-propyl sulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + pentamethylene sulfide
S-adenosyl-L-homocysteine + pentamethylenemethylsulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + selenium
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + sulfur
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + tellurium
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + tetrahydrothiophene
S-adenosyl-L-homocysteine + methyltetrahydrothiophene
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + thiomorpholine
S-adenosyl-L-homocysteine + methylthiomorpholine
show the reaction diagram
-
-
-
?
additional information
?
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-
strain- and infection-related alterations in sleep may be influenced by Temt expression and perhaps by subsequent effects on prostaglandin metabolism, mice treated with the Temt-inhibitor sinefungin develop enhanced sleep
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + selenium
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + sulfur
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + tellurium
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
strain- and infection-related alterations in sleep may be influenced by Temt expression and perhaps by subsequent effects on prostaglandin metabolism, mice treated with the Temt-inhibitor sinefungin develop enhanced sleep
-
-
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ethyl vinyl sulfide
-
suicide substrate, inactivation rate constant: 0.05/min, dimethyl sulfide protects
methyl ethyl vinyl sulfonium
-
product of ethyl vinyl sulfide methylation inactivates
S-adenosyl-L-homocysteine
-
0.04 mM, 50% inhibition
sinefungin
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0004
dimethyl selenide
-
-
0.001
Dimethyl sulfide
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.275
ethyl vinyl sulfide
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suicide substrate
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.3
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sharp drop in activity below
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
28000
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
DEAE, gel filtration, chromatofocusing
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
cloning of cDNA
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
upon exposure of pregnant mice to sodium arsenate in drinking water and subsequent injection of offspring on postpartum days 1-5 with diethylstilbestrol, transcripts for homocysteine cycling genes betaine-homocysteine methyltransferase and thioether S-methyltransferase and developmental marker genes alpha-fetoprotein, insulin-like growth factor 2 and IGF binding protein-1 are higher than with either treatment alone
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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exposure of the mouse to arsenic during a critical period of fetal development may potentially alter adrenal genetic programming, leading to endocrine disruption and potentially enhancing tumor formation together with diethylstilbestrol at other sites much later in life