Reference on EC 2.1.1.80 - protein-glutamate O-methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Park, J.; Greenstein, J.I.; Paik, W.K.; Kim, S.
Studies on protein methyltransferase in human cerebrospinal fluid
J. Mol. Neurosci.
1
151-157
1989
Homo sapiens
Sellinger, O.Z.; Wolfson, M.F.
Carboxylmethylation affects the proteolysis of myelin basic protein by Staphylococcus aureus V8 proteinase
Biochim. Biophys. Acta
1080
110-118
1991
Bos taurus
Gilbert, J.M.; Fowler, A.; Bleibaum, J.; Clarke, S.
Purification of homologous protein carboxyl methyltransferase isozymes from human and bovine erythrocytes
Biochemistry
27
5227-5233
1988
Bos taurus, Homo sapiens
Ingrosso, D.; Fowler, A.V.; Bleibaum, J.; Clarke, S.
Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases
J. Biol. Chem.
264
20131-20139
1989
Homo sapiens
Lowenson, J.D.; Clarke, S.
Identification of isoaspartyl-containing sequences in peptides and proteins that are usually poor substrates for the class II protein carboxyl methyltransferase
J. Biol. Chem.
265
3106-3110
1990
Gallus gallus, Homo sapiens
Ingrosso, D.; Kagan, R.M.; Clarke, S.
Distinct C-terminal sequences of isozymes I and II of the human erythrocyte L-isoaspartyl/D-aspartyl protein methyltransferase [published erratum appears in Biochem Biophys Res Commun 1991 Apr 15;176(1):549]
Biochem. Biophys. Res. Commun.
175
351-358
1991
Homo sapiens
Lowenson, J.D.; Clarke, S.
Structural elements affecting the recognition of L-isoaspartyl residues by the L-isoaspartyl/D-aspartyl protein methyltransferase. Implications for the repair hypothesis
J. Biol. Chem.
266
19396-19406
1991
Homo sapiens
Simms, S.A.; Stock, A.M.; Stock, J.B.
Purification and characterization of the S-adenosylmethionine:glutamyl methyltransferase that modifies membrane chemoreceptor proteins in bacteria
J. Biol. Chem.
262
8537-8543
1987
BRENDA: Salmonella enterica subsp. enterica serovar Typhimurium
Textmining: Bacteria
Springer, W.R.; Koshland, D.E.
Identification of a protein methyltransferase as the cheR gene product in the bacterial sensing system
Proc. Natl. Acad. Sci. USA
74
533-537
1977
Salmonella enterica subsp. enterica serovar Typhimurium
Burgess-Cassler, A.; Ullah, A.H.J.; Ordal, G.W.
Purification and characterization of Bacillus subtilis methyl-accepting chemotaxis protein methyltransferase II
J. Biol. Chem.
257
8412-8417
1982
Bacillus subtilis
Kleene, S.J.; Toews, M.L.; Adler, J.
Isolation of glutamic acid methyl ester from an Escherichia coli membrane protein involved in chemotaxis
J. Biol. Chem.
252
3214-3218
1977
Escherichia coli
Stock, J.B.; Clarke, S.; Koshland, D.E.
The protein carboxylmethyltransferase involved in Escherichia coli and Salmonella typhimurium chemotaxis
Methods Enzymol.
106
310-321
1984
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Kim, S.
S-Adenosylmethionine: protein-carboxyl O-methyltransferase (protein methylase II)
Methods Enzymol.
106
295-309
1984
Bacillus subtilis, Bos taurus, Escherichia coli, Homo sapiens, Mammalia, Salmonella enterica subsp. enterica serovar Typhimurium
Rollins, C.M.; Dahlquist, F.W.
Methylation of chemotaxis-specific proteins in Escherichia coli cells permeable to S-adenosylmethionine
Biochemistry
19
4627-4632
1980
Escherichia coli
Clarke, S.
Protein carboxyl methyltransferases: two distinct classes of enzymes
Annu. Rev. Biochem.
54
479-506
1985
Bacillus subtilis, Escherichia coli, Mammalia, Salmonella enterica subsp. enterica serovar Typhimurium
Ullah, A.H.J.; Ordal, G.W.
Purification and characterization of methyl-accepting chemotaxis protein methyltransferase I in Bacillus subtilis
Biochem. J.
199
795-805
1981
Bacillus subtilis
Simms, S.A.; Subbaramaiah, K.
The kinetic mechanism of S-adenosyl-L-methionine: glutamylmethyltransferase from Salmonella typhimurium
J. Biol. Chem.
266
12741-12746
1991
BRENDA: Salmonella enterica subsp. enterica serovar Typhimurium
Textmining: Dialysis
Alleman, M.M.; Mann, V.H.; Bacchi, C.J.; Yarlett, N.; Gottlieb, M.; Dwyer, D.M.
Crithidia luciliae: effect of purine starvation on S-adenosyl-L-methionine uptake and protein methylation
Exp. Parasitol.
81
519-528
1995
Crithidia luciliae
Hurst, J.H.; Guchhait, R.B.; Billingsley, M.L.; Stolk, J.M.; Lovenberg, W.
Phenylethanolamine N-methyltransferase: notes on its purification from bovine adrenal medulla and separation from protein carboxymethyltransferase
Biochem. Biophys. Res. Commun.
112
1061-1068
1983
Bos taurus
Lybarger, S.R.; Maddock, J.R.
Clustering of the chemoreceptor complex in Escherichia coli is independent of the methyltransferase CheR and the methylesterase CheB
J. Bacteriol.
181
5527-5529
1999
Escherichia coli
Perez, E.; West, A.H.; Stock, A.M.; Djordjevic, S.
Discrimination between different methylation states of chemotaxis receptor Tar by receptor methyltransferase CheR
Biochemistry
43
953-961
2004
Salmonella enterica
Ying, Z.; Mulligan, R.M.; Janney, N.; Houtz, R.L.
Rubisco small and large subunit N-methyltransferases. Bi- and mono-functional methyltransferases that methylate the small and large subunits of Rubisco
J. Biol. Chem.
274
36750-36756
1999
Nicotiana tabacum, Pisum sativum, Spinacia oleracea, Spinacia oleracea (O80013)
Li, M.; Hazelbauer, G.L.
The carboxyl-terminal linker is important for chemoreceptor function
Mol. Microbiol.
60
469-479
2006
Escherichia coli
Park, J.S.; Cho, J.Y.; Kim, S.S.; Bae, H.J.; Han, J.W.; Lee, H.W.; Hong, S.Y.
Immunoglobulin can be functionally regulated by protein carboxylmethylation in Fc region
Arch. Pharm. Res.
29
384-393
2006
Sus scrofa
Lai, W.C.; Hazelbauer, G.L.
Carboxyl-terminal extensions beyond the conserved pentapeptide reduce rates of chemoreceptor adaptational modification
J. Bacteriol.
187
5115-5121
2005
Escherichia coli
Perez, E.; Zheng, H.; Stock, A.M.
Identification of methylation sites in Thermotoga maritima chemotaxis receptors
J. Bacteriol.
188
4093-4100
2006
BRENDA: Thermotoga maritima
Textmining: Escherichia coli, Salmonella enterica
Koch, M.K.; Staudinger, W.F.; Siedler, F.; Oesterhelt, D.
Physiological sites of deamidation and methyl esterification in sensory transducers of Halobacterium salinarum
J. Mol. Biol.
380
285-302
2008
Halobacterium salinarum
Scott, A.E.; Simon, E.; Park, S.K.; Andrews, P.; Zusman, D.R.
Site-specific receptor methylation of FrzCD in Myxococcus xanthus is controlled by a tetra-trico peptide repeat (TPR) containing regulatory domain of the FrzF methyltransferase
Mol. Microbiol.
69
724-735
2008
Myxococcus xanthus
Muppirala, U.K.; Desensi, S.; Lybrand, T.P.; Hazelbauer, G.L.; Li, Z.
Molecular modeling of flexible arm-mediated interactions between bacterial chemoreceptors and their modification enzyme
Protein Sci.
18
1702-1714
2009
Escherichia coli
Webb, K.J.; Lipson, R.S.; Al-Hadid, Q.; Whitelegge, J.P.; Clarke, S.G.
Identification of protein N-terminal methyltransferases in yeast and humans
Biochemistry
49
5225-5235
2010
Saccharomyces cerevisiae
Sahr, T.; Adam, T.; Fizames, C.; Maurel, C.; Santoni, V.
O-carboxyl- and N-methyltransferases active on plant aquaporins
Plant Cell Physiol.
51
2092-2104
2010
BRENDA: Arabidopsis thaliana
Textmining: plant, eukaryota
Batra, M.; Sharma, R.; Chandra, V.; Aggarwal, M.; Agarwal, U.; Gupta, P.; Singh, R.P.; Tomar, S.
In silico and proteomic analysis of protein methyltransferase CheR from Bacillus subtilis
Int. J. Biol. Macromol.
77
168-180
2015
BRENDA: Bacillus subtilis
Textmining: Bacteria
Garcia-Fontana, C.; Reyes-Darias, J.A.; Munoz-Martinez, F.; Alfonso, C.; Morel, B.; Ramos, J.L.; Krell, T.
High specificity in CheR methyltransferase function: CheR2 of Pseudomonas putida is essential for chemotaxis, whereas CheR1 is involved in biofilm formation
J. Biol. Chem.
288
18987-18999
2013
Pseudomonas putida (Q88ER1), Pseudomonas putida (Q88GG4), Pseudomonas putida (Q88MS8), Pseudomonas putida, Pseudomonas putida KT 2240 (Q88ER1), Pseudomonas putida KT 2240 (Q88GG4), Pseudomonas putida KT 2240 (Q88MS8)
Drozak, J.; Piecuch, M.; Poleszak, O.; Kozlowski, P.; Chrobok, L.; Baelde, H.J.; de Heer, E.
UPF0586 protein C9orf41 homolog is anserine-producing methyltransferase
J. Biol. Chem.
290
17190-17205
2015
eukaryota
Garcia-Fontana, C.; Lugo, A.; Krell, T.
Structural biology: Specificity of the CheR2 methyltransferase in Pseudomonas aeruginosa is directed by a C-terminal pentapeptide in the McpB chemoreceptor
Sci. Signal.
7
ra34
2014
BRENDA: Pseudomonas aeruginosa (Q9I6V7), Pseudomonas aeruginosa
Textmining: insertion sequences
Duggan, P.; Thiel, T.; Adams, D.
Symbiosis between the cyanobacterium Nostoc and the liverwort Blasia requires a CheR-type MCP methyltransferase
Symbiosis
59
111-120
2013
Nostoc punctiforme (B2J4R2), Nostoc punctiforme ATCC 29133 (B2J4R2)
-
Batra, M.; Sharma, R.; Malik, A.; Dhindwal, S.; Kumar, P.; Tomar, S.
Crystal structure of pentapeptide-independent chemotaxis receptor methyltransferase (CheR) reveals idiosyncratic structural determinants for receptor recognition
J. Struct. Biol.
196
364-374
2016
Bacillus subtilis
Li, M.; Hazelbauer, G.L.
Methyltransferase CheR binds to its chemoreceptor substrates independent of their signaling conformation yet modifies them differentially
Protein Sci.
29
443-454
2020
Escherichia coli
Vinogradova, RP; Kucherenko, NE; Demchenko, IB
[Effect of ionizing radiation on methylation of lysyl tRNA synthetase from rat liver]
Radiobiologiia
26
88-91
0
Rattus
Seiboth, B; Karimi, RA; Phatale, PA; Linke, R; Hartl, L; Sauer, DG; Smith, KM; Baker, SE; Freitag, M; Kubicek, CP
The putative protein methyltransferase LAE1 controls cellulase gene expression in Trichoderma reesei.
Mol Microbiol
84
1150-64
2012
Trichoderma reesei
Gillet, L; Looze, Y; Deconinck, M; Léonis, J
Binding capacities of various analogues of S-adenosyl-L-homocysteine to protein methyltransferase II from human erythrocytes.
Experientia
35
1007-9
1979
Homo sapiens
O'Dea, RF; Viveros, OH; Acheson, A; Gorman, C; Axelrod, J
Protein carboxymethylase and methyl-acceptor proteins in human platelets and erythrocytes.
Biochem Pharmacol
27
679-84
1978
Homo sapiens
Polastro, ET; Deconinck, MM; Devogel, MR; Mailier, EL; Looza, YB; Schnek, AG; Léonis, J
Purification and some molecular properties of protein methylase II from equine erythrocytes.
Biochem Biophys Res Commun
81
920-7
1978
Equus caballus
Gagnon, C; Axelrod, J; Brownstein, MJ
Protein carboxymethylation: effects of 2% sodium chloride administration on protein carboxymethylase and its endogenous substrates in rat posterior pituitary.
Life Sci
22
2155-64
1978
Rattus
Gagnon, C; Axelrod, J
Subcellular localization of protein carboxyl-methylase and its substrates in rat pituitary lobes.
J Neurochem
32
567-72
1979
Rattus
Kim, S; Wasserman, L; Lew, B; Ki Paik, W
Studies on the effect of hypophysectomy on protein methylase II of rat.
FEBS Lett
51
164-7
1975
Rattus
Li, C; Clarke, S
A protein methyltransferase specific for altered aspartyl residues is important in Escherichia coli stationary-phase survival and heat-shock resistance.
Proc Natl Acad Sci U S A
89
9885-9
1992
Escherichia coli
MacLaren, DC; O'Connor, CM; Xia, YR; Mehrabian, M; Klisak, I; Sparkes, RS; Clarke, S; Lusis, AJ
The L-isoaspartyl/D-aspartyl protein methyltransferase gene (PCMT1) maps to human chromosome 6q22.3-6q24 and the syntenic region of mouse chromosome 10.
Genomics
14
852-6
1992
Homo sapiens, Mus musculus
Li, C; Clarke, S
Distribution of an L-isoaspartyl protein methyltransferase in eubacteria.
J Bacteriol
174
355-61
1992
Bacteria
Young, PR; Waickus, CM
Purification and kinetic mechanism of S-adenosylmethionine: myelin basic protein methyltransferase from bovine brain.
Biochem J
250
221-6
1988
Bos taurus
Nuske, JH
Protein methylase II in five taxa from three phyla.
Comp Biochem Physiol B
86
37-47
1987
Phyla, Astacus leptodactylus, Locusta migratoria migratorioides, Torpedo marmorata, Bos taurus, Dictyostelium discoideum, Dictyostelium, Torpedo
Paik, MK; Hwang, BD; Lim, K
Human placenta S-adenosylmethionine: protein carboxyl O-methyltransferase (protein methylase II). Purification and characterization.
Int J Biochem
20
1107-12
1988
Homo sapiens
Avila, JL; Avila, A
Correlation of sinefungin susceptibility and drug-affinity for protein carboxymethyltransferase activity in American Leishmania species.
Mol Biochem Parasitol
26
69-75
1987
Leishmania, Leishmania mexicana
O'Connor, CM
Regulation and subcellular distribution of a protein methyltransferase and its damaged aspartyl substrate sites in developing Xenopus oocytes.
J Biol Chem
262
10398-403
1987
Xenopus, Xenopus laevis
Nuske, JH
Stimulation of protein methylase II from Torpedo marmorata by cholinergic effectors.
Biochim Biophys Acta
854
124-32
1986
Torpedo marmorata
Gilad, GM; Gagnon, C; Kopin, IJ
Protein carboxymethylase activity in the rat superior cervical ganglion during development and after axonal injury.
Brain Res
183
393-402
1980
Rattus
Gilliland, EL; Turner, N; Steer, ML
The effects of ethionine administration and choline deficiency on protein carboxymethylase activity in mouse pancreas.
Biochim Biophys Acta
672
280-7
1981
Mus musculus
Pierré, A; Robert-Géro, M
Selective methylation of rous sarcoma virus glycoproteins by protein methylase II.
FEBS Lett
113
115-9
1980
Rous sarcoma virus
Kim, S; Choi, J; Jun, GJ
Purification of protein methylase II from human erythrocytes.
J Biochem Biophys Methods
8
9-14
1983
Homo sapiens
Aswad, DW; Deight, EA
Purification and characterization of two distinct isozymes of protein carboxymethylase from bovine brain.
J Neurochem
40
1718-26
1983
Bos taurus
Clarke, S; Sparrow, K; Panasenko, S; Koshland, DE
In vitro methylation of bacterial chemotaxis proteins: characterization of protein methyltransferase activity in crude extracts of Salmonella typhimurium.
J Supramol Struct
13
315-28
1980
Salmonella enterica subsp. enterica serovar Typhimurium
Cusan, L; Andersen, D; Tuen, E; Hansson, V
Changes in protein carboxyl-methylase isoenzymes during testicular development in the rat.
Arch Androl
8
285-92
1982
Rattus
O'Dea, RF; Pons, G; Hansen, JA; Mirkin, BL
Characterization of protein carboxyl-O-methyltransferase in the spontaneous in vivo murine C-1300 neuroblastoma.
Cancer Res
42
4433-6
1982
Mus musculus
Borchardt, RT; Kuonen, D; Huber, JA; Moorman, A
Inhibition of calf thymus and rat hypothalamic synaptosomal protein carboxymethyltransferase by analogues of S-adenosylhomocysteine.
Mol Pharmacol
21
181-6
1982
Rattus
Trivedi, L; Gupta, A; Ki Paik, W; Kim, S
Purification and properties of protein methylase II from wheat germ.
Eur J Biochem
128
349-54
1982
Triticum aestivum, Rattus
Pollack, BP; Kotenko, SV; He, W; Izotova, LS; Barnoski, BL; Pestka, S
The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.
J Biol Chem
274
31531-42
1999
Saccharomyces cerevisiae, Homo sapiens
Lee, JH; Cook, JR; Pollack, BP; Kinzy, TG; Norris, D; Pestka, S
Hsl7p, the yeast homologue of human JBP1, is a protein methyltransferase.
Biochem Biophys Res Commun
274
105-11
2000
Saccharomyces cerevisiae, Homo sapiens
Kim, YM; Ahn, SH; Seo, DW; Kim, YK; Han, JW; Hong, S; Kim, S; Paik, WK; Lee, HW
Purification and characterization of protein methylase II from Helicobacter pylori.
FEMS Microbiol Lett
195
53-8
2001
Helicobacter pylori
Bao, S; Qyang, Y; Yang, P; Kim, H; Du, H; Bartholomeusz, G; Henkel, J; Pimental, R; Verde, F; Marcus, S
The highly conserved protein methyltransferase, Skb1, is a mediator of hyperosmotic stress response in the fission yeast Schizosaccharomyces pombe.
J Biol Chem
276
14549-52
2001
Schizosaccharomyces pombe, Homo sapiens
Wiley, DJ; Marcus, S; D'urso, G; Verde, F
Control of cell polarity in fission yeast by association of Orb6p kinase with the highly conserved protein methyltransferase Skb1p.
J Biol Chem
278
25256-63
2003
Schizosaccharomyces pombe
Cho, JY; Kim, SS; Kwon, MH; Kim, SH; Lee, HW; Hong, S
Protein carboxylmethylation in porcine spleen is mainly mediated by class I protein carboxyl O-methyltransferase.
Arch Pharm Res
27
206-16
2004
Sus scrofa
Doukov, TI; Zhao, S; Ross, CR; Roberts, DL; Kim, JJ; Ragsdale, SW; Stezowski, JJ
Preliminary X-ray crystallographic study of methyltetrahydrofolate: corrinoid/iron sulfur protein methyltransferase from Clostridium thermoaceticum.
Acta Crystallogr D Biol Crystallogr
51
1092-3
1995
Moorella thermoacetica
Schmidt, J; Msken, M; Becker, T; Magnowska, Z; Bertinetti, D; Mller, S; Zimmermann, B; Herberg, FW; Jnsch, L; Hussler, S
The Pseudomonas aeruginosa Chemotaxis Methyltransferase CheR1 Impacts on Bacterial Surface Sampling.
PLoS One
6
e18184
2011
Pseudomonas aeruginosa
Kernstock, S; Davydova, E; Jakobsson, M; Moen, A; Pettersen, S; Mlandsmo, GM; Egge-Jacobsen, W; Falnes, P
Lysine methylation of VCP by a member of a novel human protein methyltransferase family.
Nat Commun
3
1038
2012
Homo sapiens
Basavapathruni, A; Jin, L; Daigle, SR; Majer, CR; Therkelsen, CA; Wigle, TJ; Kuntz, KW; Chesworth, R; Pollock, RM; Scott, MP; Moyer, MP; Richon, VM; Copeland, RA; Olhava, EJ
Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L.
Chem Biol Drug Des
2012
Homo sapiens
Weimann, M; Grossmann, A; Woodsmith, J; Ozkan, Z; Birth, P; Meierhofer, D; Benlasfer, N; Valovka, T; Timmermann, B; Wanker, EE; Sauer, S; Stelzl, U
A Y2H-seq approach defines the human protein methyltransferase interactome.
Nat Methods
10
339-42
2013
Homo sapiens
Karimi Aghcheh, R; Druzhinina, IS; Kubicek, CP
The putative protein methyltransferase LAE1 of Trichoderma atroviride is a key regulator of asexual development and mycoparasitism.
PLoS One
8
e67144
2013
Trichoderma atroviride, Ascomycota
Li, Z; Yu, J; Hosohama, L; Nee, K; Gkountela, S; Chaudhari, S; Cass, AA; Xiao, X; Clark, AT
The Sm protein methyltransferase PRMT5 is not required for primordial germ cell specification in mice.
EMBO J
34
748-758
2015
Mus sp.
Mazzoleni, M; Figuet, S; Martin-Laffon, J; Mininno, M; Gilgen, A; Leroux, M; Brugire, S; Tardif, M; Alban, C; Ravanel, S
Dual Targeting of the Protein Methyltransferase PrmA Contributes to Both Chloroplastic and Mitochondrial Ribosomal Protein L11 Methylation in Arabidopsis.
Plant Cell Physiol
56
1697-710
2015
Arabidopsis
Chen, PB; Ding, S; Zangh, G; Soulard, V; DiMaggio, PA; Fuchter, MJ; Mecheri, S; Mazier, D; Scherf, A; Malmquist, NA
Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites.
Sci Rep
6
21802
2016
Plasmodium falciparum
Woodcock, CB; Yu, D; Zhang, X; Cheng, X
Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm112.
Cell Discov
5
50
2019
Homo sapiens
Li, W; Shi, Y; Zhang, T; Ye, J; Ding, J
Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase.
Cell Discov
5
51
2019
Homo sapiens
Park, MJ; Liao, J; Kim, DI
TC-E 5003, a protein methyltransferase 1 inhibitor, activates the PKA-dependent thermogenic pathway in primary murine and human subcutaneous adipocytes.
FEBS Lett
2020
Homo sapiens, Mus musculus
Alcoforado Diniz, J; Chaves, MM; Vaselek, S; Miserani Magalhes, RD; Ricci-Azevedo, R; de Carvalho, RVH; Lorenzon, LB; Ferreira, TR; Zamboni, D; Walrad, PB; Volf, P; Sacks, DL; Cruz, AK
Protein methyltransferase 7 deficiency in Leishmania major increases neutrophil associated pathology in murine model.
PLoS Negl Trop Dis
15
e0009230
2021
Leishmania major, Mus musculus
Stephenson, RC; Clarke, S
Characterization of a rat liver protein carboxyl methyltransferase involved in the maturation of proteins with the -CXXX C-terminal sequence motif.
J Biol Chem
267
13314-9
1992
Rattus
Aswad, DW; Deight, EA
Endogenous substrates for protein carboxyl methyltransferase in cytosolic fractions of bovine brain.
J Neurochem
41
1702-9
1983
Bos taurus
McFadden, PN; Horwitz, J; Clarke, S
Protein carboxyl methyltransferase from cow eye lens.
Biochem Biophys Res Commun
113
418-24
1983
Bos taurus, Homo sapiens
Chanderkar, LP; Shanker, G; Knobler, RL; Lublin, FD; Paik, WK; Kim, S
Reduced S-adenosylmethionine:protein-lysine N-methyltransferase activity (protein methylase III) in shiverer mutant mouse brain.
Neurochem Res
12
445-9
1987
Mus sp., Mus musculus
Diao, W; Zhou, H; Pan, W; Liu, H; Shen, Y; Xu, Y; Li, X; Cao, J
Expression and immune characterization of a novel enzyme, protein arginine methyltransferase 1, from Schistosoma japonicum.
Parasitol Res
113
919-24
2014
Schistosoma japonicum, Homo sapiens
Murata, M; Azuma, Y; Miura, K; Rahman, MA; Matsutani, M; Aoyama, M; Suzuki, H; Sugi, K; Shirai, M
Chlamydial SET domain protein functions as a histone methyltransferase.
Microbiology
153
585-92
2007
Mus musculus
Chu, Y; Zhu, Y; Chen, Y; Li, W; Zhang, Z; Liu, D; Wang, T; Ma, J; Deng, H; Liu, ZJ; Ouyang, S; Huang, L
aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperthermophilic Archaeon Sulfolobus islandicus but is Dispensable for the Growth of the Organism.
Mol Cell Proteomics
15
2908-23
2016
Sulfolobus islandicus
Hayashi, N; Furue, Y; Kai, D; Yamada, N; Yamamoto, H; Nakano, T; Oda, M
Sulfated vizantin suppresses mucin layer penetration dependent on the flagella motility of Pseudomonas aeruginosa PAO1.
PLoS One
13
e0206696
2018
Pseudomonas aeruginosa PAO1, Calophysus macropterus
Ichikawa, JK; Li, C; Fu, J; Clarke, S
A gene at 59 minutes on the Escherichia coli chromosome encodes a lipoprotein with unusual amino acid repeat sequences.
J Bacteriol
176
1630-8
1994
Escherichia coli
Purvis, K; Cusan, L; Attramadal, H; Ege, A; Hansson, V
Rat sperm enzymes during epididymal transit.
J Reprod Fertil
65
381-7
1982
Rattus
Li, C; Ichikawa, JK; Ravetto, JJ; Kuo, HC; Fu, JC; Clarke, S
A new gene involved in stationary-phase survival located at 59 minutes on the Escherichia coli chromosome.
J Bacteriol
176
6015-22
1994
Escherichia coli
Wang, C; Mu, Z; Ye, Z; Zhang, Z; Abu-Khalaf, MM; Silver, DP; Palazzo, JP; Jagannathan, G; Fellin, FM; Bhattacharya, S; Jaslow, RJ; Tsangaris, TN; Berger, A; Neupane, M; Cescon, TP; Lopez, A; Yao, K; Chong, W; Lu, B; Myers, RE; Hou, L; Wei, Q; Li, B; Cristofanilli, M; Yang, H
Prognostic value of HER2 status on circulating tumor cells in advanced-stage breast cancer patients with HER2-negative tumors.
Breast Cancer Res Treat
181
679-689
2020
Homo sapiens
Goggins, M; Scott, JM; Weir, DG
Regional differences in protein carboxymethylation in post-mortem human brain.
Clin Sci (Lond)
94
677-85
1998
Homo sapiens, Sus scrofa
Kim, S; Lew, B; Chang, FN
Enzymatic methyl esterification of Escherichia coli ribosomal proteins.
J Bacteriol
130
839-45
1977
Escherichia coli
Strittmatter, WJ; Gagnon, C; Axelrod, J
Beta adrenergic stimulation of protein carboxymethylation and amylase secretion in rat parotid gland.
J Pharmacol Exp Ther
207
419-24
1978
Rattus
Billingsley, ML; Kim, S; Kuhn, DM
Immunohistochemical localization of protein-O-carboxylmethyltransferase in rat brain neurons.
Neuroscience
15
159-71
1985
Rattus, Homo sapiens, Bos taurus, Rodentia, Hippocampus, Areas
Ro, JY; DiMaria, P; Kim, S
Differential membrane protein carboxyl-methylation of intact human erythrocytes by exogenous methyl donors.
Biochem J
219
743-9
1984
Homo sapiens
Liu, P; Nie, S; Li, B; Yang, ZQ; Xu, ZM; Fei, J; Lin, C; Zeng, R; Xu, GL
Deficiency in a glutamine-specific methyltransferase for release factor causes mouse embryonic lethality.
Mol Cell Biol
30
4245-53
2010
Mammalia
Wainfan, E; Kilkenny, M; Dizik, M
Comparison of methyltransferase activities of pair-fed rats given adequate or methyl-deficient diets.
Carcinogenesis
9
861-3
1988
Rattus, Metazoa
Toney, K; Bateman, A; Gagnon, C; Bennett, HP
Aspartimide formation in the joining peptide sequence of porcine and mouse pro-opiomelanocortin.
J Biol Chem
268
1024-31
1993
Bos taurus
Yarlett, N; Quamina, A; Bacchi, CJ
Protein methylases in Trypanosoma brucei brucei: activities and response to DL-alpha-difluoromethylornithine.
J Gen Microbiol
137
717-24
1991
Balitora brucei
Amur, SG; Shanker, G; Cochran, JM; Ved, HS; Pieringer, RA
Correlation between inhibition of myelin basic protein (arginine) methyltransferase by sinefungin and lack of compact myelin formation in cultures of cerebral cells from embryonic mice.
J Neurosci Res
16
367-76
1986
Metazoa
Saavedra, JM; Kloog, Y; Chevillard, C; Fernandez-Pardal, J
High-protein carboxymethylase activity and low endogenous methyl acceptor proteins in posterior pituitary lobe of rats lacking neurophysin-vasopressin (Brattleboro rats).
J Neurochem
41
195-200
1983
Rattus
Zuckerman, SH; O'Dea, RF; Olson, JM; Douglas, SD
Protein carboxymethylation during in vitro culture of human peripheral blood monocytes and pulmonary alveolar macrophages.
Mol Immunol
19
281-6
1982
Homo sapiens
Kim, S; Galletti, P; Paik, WK
In vivo carboxyl methylation of human eruthrocyte membrane proteins.
J Biol Chem
255
338-41
1980
Homo sapiens
Rus, F; Kurucz, E; Márkus, R; Sinenko, SA; Laurinyecz, B; Pataki, C; Gausz, J; Hegedus, Z; Udvardy, A; Hultmark, D; Andó, I
Expression pattern of Filamin-240 in Drosophila blood cells.
Gene Expr Patterns
6
928-34
2006
Drosophila, Leptopilina boulardi
Perez, E; Stock, AM
Characterization of the Thermotoga maritima chemotaxis methylation system that lacks pentapeptide-dependent methyltransferase CheR:MCP tethering.
Mol Microbiol
63
363-78
2007
Escherichia coli, Salmonella enterica
Willemsen, NM; Hitchen, EM; Bodetti, TJ; Apolloni, A; Warrilow, D; Piller, SC; Harrich, D
Protein methylation is required to maintain optimal HIV-1 infectivity.
Retrovirology
3
92
2006
Human immunodeficiency virus 1
Kirino, Y; Vourekas, A; Kim, N; de Lima Alves, F; Rappsilber, J; Klein, PS; Jongens, TA; Mourelatos, Z
Arginine methylation of vasa protein is conserved across phyla.
J Biol Chem
285
8148-54
2010
Drosophila melanogaster
Webb, KJ; Zurita-Lopez, C; Al-Hadid, Q; Laganowsky, A; Young, BD; Lipson, RS; Souda, P; Faull, KF; Whitelegge, JP; Clarke, SG
A novel 3-methylhistidine modification of yeast Ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase.
J Biol Chem
2010
Saccharomyces cerevisiae
Deloney-Marino, CR; Visick, KL
Role for cheR of Vibrio fischeri in the Vibrio-squid symbiosis.
Can J Microbiol
58
29-38
2012
Vidua fischeri, Doryteuthis pealeii
Zhang, Y; Dong, K; Zeng, L; Li, Q; Liu, C; Wang, J; Guo, X; Zhao, GP
Genetic and molecular biological characterization of two homologous cheR genes from Leptospira interrogans.
Acta Biochim Biophys Sin (Shanghai)
45
806-16
2013
Leptospira interrogans, Escherichia coli
Low, JK; Hart-Smith, G; Erce, MA; Wilkins, MR
The Saccharomyces cerevisiae poly(A)-binding protein is subject to multiple post-translational modifications, including the methylation of glutamic acid.
Biochem Biophys Res Commun
443
543-8
2014
Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Salmonella enterica subsp. enterica serovar Typhimurium
Billingsley, ML; Kincaid, RL; Lovenberg, W
Stoichiometric methylation of calcineurin by protein carboxyl O-methyltransferase and its effects on calmodulin-stimulated phosphatase activity.
Proc Natl Acad Sci U S A
82
5612-6
1985
Bos taurus
Syed, SK; Kim, S; Paik, WK
Identification of the S-adenosyl-L-methionine binding site of protein-carboxyl O-methyltransferase using 8-azido-S-adenosyl-L-methionine.
Biochemistry
32
2242-7
1993
Rattus
Galletti, P; Ki Paik, W; Kim, S
Methyl acceptors for protein methylase II from human-erythrocyte membrane.
Eur J Biochem
97
221-7
1979
Homo sapiens
Jamaluddin, M; Kim, S; Paik, WK
A comparison of kinetic parameters of polypeptide substrates for protein methylase II.
Biochemistry
15
3077-81
1976
Bos taurus
Jamaluddin, M; Kim, S; Paik, WK
Studies on the kinetic mechanism of S-adenosylmethionine: protein O-methyltransferase of calf thymus.
Biochemistry
14
694-8
1975
Bos taurus
Bouchard, P; Gagnon, C; Phillips, DM; Bardin, CW
The localization of protein carboxyl-methylase in sperm tails.
J Cell Biol
86
417-23
1980
Oryctolagus cuniculus, Rattus
Djordjevic, S; Stock, AM
Crystal structure of the chemotaxis receptor methyltransferase CheR suggests a conserved structural motif for binding S-adenosylmethionine.
Structure
5
545-58
1997
Salmonella enterica subsp. enterica serovar Typhimurium
Djordjevic, S; Stock, AM
Chemotaxis receptor recognition by protein methyltransferase CheR.
Nat Struct Biol
5
446-50
1998
Salmonella enterica subsp. enterica serovar Typhimurium
Lin, Q; Jiang, F; Schultz, PG; Gray, NS
Design of allele-specific protein methyltransferase inhibitors.
J Am Chem Soc
123
11608-13
2001
Saccharomyces cerevisiae
Chan, LH; Zhou, L; Ng, KY; Wong, TL; Lee, TK; Sharma, R; Loong, JH; Ching, YP; Yuan, YF; Xie, D; Lo, CM; Man, K; Artegiani, B; Clevers, H; Yan, HH; Leung, SY; Richard, S; Guan, XY; Huen, MSY; Ma, S
PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.
Cell Rep
25
690-701.e8
2018
Homo sapiens
Burgos, ES; Wilczek, C; Onikubo, T; Bonanno, JB; Jansong, J; Reimer, U; Shechter, D
Histone H2A and H4 N-Terminal Tails are Positioned by the MEP50 WD-Repeat Protein for Efficient Methylation by the PRMT5 Arginine Methyltransferase.
J Biol Chem
2015
Xenopus laevis, Homo sapiens
Bar, C; Patil, R; Doshi, J; Kulkarni, MJ; Gade, WN
Characterization of the proteins of bacterial strain isolated from contaminated site involved in heavy metal resistance--a proteomic approach.
J Biotechnol
128
444-51
2007
Klebsiella pneumoniae
McFadden, PN; Clarke, S
Methylation at D-aspartyl residues in erythrocytes: possible step in the repair of aged membrane proteins.
Proc Natl Acad Sci U S A
79
2460-4
1982
Homo sapiens
O'Connor, CM; Clarke, S
Methylation of erythrocyte membrane proteins at extracellular and intracellular D-aspartyl sites in vitro. Saturation of intracellular sites in vivo.
J Biol Chem
258
8485-92
1983
Homo sapiens
Diliberto, EJ; Axelrod, J; Chaiken, IM
The effects of ligands on enzymic carboxyl-methylation of neurophysins.
Biochem Biophys Res Commun
73
1063-7
1976
Bos taurus
Bhatt, NP; Patel, K; Borchardt, RT
Chemical pathways of peptide degradation. I. Deamidation of adrenocorticotropic hormone.
Pharm Res
7
593-9
1990
Bos taurus
Li, C; Ai, LS; Lin, CH; Hsieh, M; Li, YC; Li, SY
Protein N-arginine methylation in adenosine dialdehyde-treated lymphoblastoid cells.
Arch Biochem Biophys
351
53-9
1998
Saccharomyces cerevisiae
Okumura, H; Nishiyama, S; Sasaki, A; Homma, M; Kawagishi, I
Chemotactic adaptation is altered by changes in the carboxy-terminal sequence conserved among the major methyl-accepting chemoreceptors.
J Bacteriol
180
1862-8
1998
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Shiomi, D; Okumura, H; Homma, M; Kawagishi, I
The aspartate chemoreceptor Tar is effectively methylated by binding to the methyltransferase mainly through hydrophobic interaction.
Mol Microbiol
36
132-40
2000
Escherichia coli
Levin, MD; Shimizu, TS; Bray, D
Binding and diffusion of CheR molecules within a cluster of membrane receptors.
Biophys J
82
1809-17
2002
Escherichia coli
Pellar, GJ; DiMario, PJ
Deletion and site-specific mutagenesis of nucleolin's carboxy GAR domain.
Chromosoma
111
461-9
2003
Saccharomyces cerevisiae
Kirino, Y; Kim, N; de Planell-Saguer, M; Khandros, E; Chiorean, S; Klein, PS; Rigoutsos, I; Jongens, TA; Mourelatos, Z
Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability.
Nat Cell Biol
11
652-8
2009
Drosophila
Dettmer, J; Ursache, R; Campilho, A; Miyashima, S; Belevich, I; O'Regan, S; Mullendore, DL; Yadav, SR; Lanz, C; Beverina, L; Papagni, A; Schneeberger, K; Weigel, D; Stierhof, YD; Moritz, T; Knoblauch, M; Jokitalo, E; Helariutta, Y
CHOLINE TRANSPORTER-LIKE1 is required for sieve plate development to mediate long-distance cell-to-cell communication.
Nat Commun
5
4276
2014
Areas, Metazoa
Xu, L; Xin, L; Zeng, Y; Yam, JK; Ding, Y; Venkataramani, P; Cheang, QW; Yang, X; Tang, X; Zhang, LH; Chiam, KH; Yang, L; Liang, ZX
A cyclic di-GMP-binding adaptor protein interacts with a chemotaxis methyltransferase to control flagellar motor switching.
Sci Signal
9
ra102
2016
Pseudomonas aeruginosa
Li, Y; Zhang, X; Liu, D; Gong, J; Wang, DD; Li, S; Peng, Z; Li, Y; Wang, X; Lin, PP; Li, M; Shen, L
Evolutionary Expression of HER2 Conferred by Chromosome Aneuploidy on Circulating Gastric Cancer Cells Contributes to Developing Targeted and Chemotherapeutic Resistance.
Clin Cancer Res
24
5261-5271
2018
Homo sapiens
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