Reference on EC 2.1.1.8 - histamine N-methyltransferase
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Brown, D.D.; Tomchick, R.; Axelrod, J.
The distribution and properties of a histamine-methylating enzyme
J. Biol. Chem.
234
2948-2950
1959
Cavia porcellus, Oryctolagus cuniculus, Felis catus, Mus musculus, Rattus norvegicus
Axelrod, J.
Histamine N-methyltransferase (pig liver)
Methods Enzymol.
17
766-769
1971
Cavia porcellus, Sus scrofa
-
Barth, H.; Lorenz, W.; Niemeyer, I.
Inhibition and activation of histamine methyltransferase by methylated histamines
Hoppe-Seyler's Z. Physiol. Chem.
354
1021-1026
1973
Sus scrofa
Francis, D.M.; Thompson, M.F.; Greaves, M.W.
The kinetic properties and reaction mechanism of histamine methyltransferase from human skin
Biochem. J.
187
819-828
1980
Homo sapiens
Bowsher, R.R.; Verburg, K.M.; Henry, D.P.
Rat histamine N-methyltransferase. Quantification, tissue distribution, purification, and immunologic properties
J. Biol. Chem.
258
12215-12220
1983
BRENDA: Rattus norvegicus
Textmining: Rattus
Harvima, R.J.; Kajander, E.O.; Harvima, I.T.; Fraki, J.E.
Purification and partial characterization of rat kidney histamine-N-methyltransferase
Biochim. Biophys. Acta
841
42-49
1985
BRENDA: Rattus norvegicus
Textmining: Rattus
Fukuda, H.; Yamatodani, A.; Imamura, I.; Maeyama, K.; Watanabe, T.; Wada, H.
High-performance liquid chromatographic determination of histamine N-methyltransferase activity
J. Chromatogr.
567
459-464
1991
Rattus norvegicus
Nishibori, M.; Oishi, R.; Itoh, Y.; Saeki, K.
Purification and partial characterization of histamine N-methyltransferase from bovine brain
Neurochem. Int.
19
135-141
1991
Bos taurus
-
Scott, M.C.; Guerciolini, R.; Szumlanski, C.; Weinshilboum, R.M.
Mouse kidney histamine N-methyltransferase: assay conditions, biochemical properties and strain variation
Agents Actions
32
194-202
1991
BRENDA: Homo sapiens, Mus musculus
Textmining: animal, Metazoa, Mus sp.
Crooks, P.A.; Hassan, S.F.; Benghiat, E.; Hemrick-Luecke, S.K.; Fuller, R.W.
5'-Thioadenosine derivatives as potent and selective inhibitors of histamine N-methyltransferase
Drug Metabol. Drug Interact.
7
111-141
1989
BRENDA: Cavia porcellus
Textmining: Oryctolagus cuniculus, Rattus
Rhim, H.; Choi, M.U.
Purification and general characterization of rat brain histamine N-methyltransferase
Hanguk Saenghwahakhoe Chi
22
455-461
1989
Rattus norvegicus
-
Gitomer, W.L.; Tipton, K.F.
Purification and kinetic properties of ox brain histamine N-methyltransferase
Biochem. J.
233
669-676
1986
BRENDA: Bos taurus
Textmining: Mus musculus, Rattus
Fuhr, N.; Kownatzki, E.
Inhibition of rat kidney histamine-N-methyltransferase by biogenic amines
Pharmacology
32
114-120
1986
BRENDA: Rattus norvegicus
Textmining: Rattus
Barth, H.; Schunack, W.; Crombach, M.; Lorenz, W.
Gastric histamine methyltransferase: different methylation rates for enantiomers of side-chain methylated histamine analogues using a highly purified enzyme preparation
Agents Actions
14
346-350
1984
Sus scrofa
Matuszewska, B.; Borchardt, R.T.
Guinea pig brain histamine N-methyltransferase: purification and partial characterization
J. Neurochem.
41
113-118
1983
Cavia porcellus
Dent, C.; Nilam, F.; Smith, I.R.
Sidechain-modified histamine analogues as substrates for histamine N-methyltransferase
Biochem. Pharmacol.
31
2297-2300
1982
Cavia porcellus
Beaven, M.A.; Roderick, N.B.
Impromidine, a potent inhibitor of histamine methyltransferase (HMT) and diamine oxidase (DAO)
Biochem. Pharmacol.
29
2897-2900
1980
Rattus norvegicus
Thithapandha, A.; Cohn, V.H.
Brain histamine N-methyltransferase purification, mechanism of action, and inhibition by drugs
Biochem. Pharmacol.
27
263-271
1978
Cavia porcellus
Matuszewska, B.; Borchardt, R.T.
Rat kidney histamine N-methyltransferase: purification and partial characterization
Prep. Biochem.
15
145-157
1985
BRENDA: Rattus norvegicus
Textmining: Rattus, Cavia porcellus
Borchardt, R.T.; Matuszewska, B.
S-adenosylmethionine dependent transmethylation of histamine: Purification and partial characterization of guinea pig brain and rat kidney histamine N-methyltransferase
Adv. Biosci.
51
163-172
1985
Cavia porcellus, Rattus norvegicus
-
Horton, J.R.; Sawada, K.; Nishibori, M.; Zhang, X.; Cheng, X.
Two polymorphic forms of human histamine methyltransferase. Structural, thermal, and kinetic comparisons
Structure
9
837-849
2001
Homo sapiens (P50135), Homo sapiens
Takemura, M.; Imamura, I.; Mizuguchi, H.; Fukui, H.; Yamatodani, A.
Tissue distribution of histamine N-methyltransferase-like immunoreactivity in rodents
Life Sci.
54
1059-1071
1994
BRENDA: Cavia porcellus, Mus musculus, Rattus norvegicus
Textmining: Rodentia, Escherichia coli, Rattus, Oryctolagus cuniculus
Yamauchi, K.; Sekizawa, K.; Suzuki, H.; Nakazawa, H.; Ohkawara, Y.; Katayose, D.; Ohtsu, H.; Tamura, G.; Shibahara, S.; et al.
Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway
Am. J. Physiol.
267
L342-L349
1994
BRENDA: Homo sapiens
Textmining: Mammalia, Rattus, Trachea
Tahara, A.; Nishibori, M.; Ohtsuka, A.; Sawada, K.; Sakiyama, J.; Saeki, K.
Immunohistochemical localization of histamine N-methyltransferase in guinea pig tissues
J. Histochem. Cytochem.
48
943-954
2000
BRENDA: Cavia porcellus
Textmining: Bos taurus, Oryctolagus cuniculus, Trachea
Preuss, C.V.; Wood, T.C.; Szumlanski, C.L.; Raftogianis, R.B.; Otterness, D.M.; Girard, B.; Scott, M.C.; Weinshilboum, R.M.
Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity
Mol. Pharmacol.
53
708-717
1998
Homo sapiens
Donatelli, P.; Marchi, G.; Giuliani, L.; Gustafsson, L.L.; Pacifici, G.M.
Stereoselective inhibition by chloroquine of histamine N-methyltransferase in the human liver and brain
Eur. J. Clin. Pharmacol.
47
345-349
1994
Homo sapiens
Pang, Y.P.; Zheng, X.E.; Weinshilboum, R.M.
Theoretical 3D model of histamine N-methyltransferase: Insights into the effects of a genetic polymorphism on enzymatic activity and thermal stability
Biochem. Biophys. Res. Commun.
287
204-208
2001
BRENDA: Homo sapiens (P50135), Homo sapiens
Textmining: Mammalia
Schwelberger, H.G.; Drasche, A.
Structure and expression of porcine histamine N-methyltransferase
Inflamm. Res.
51
S85-S86
2002
Sus scrofa
-
Raju, R.V.S.; Datla, R.S.S.; Sharma, R.K.
Expression of human N-myristoyltransferase in Escherichia coli. Comparison with N-myristoyltransferases expressed in different tissues
Mol. Cell. Biochem.
155
69-76
1996
Bos taurus, Escherichia coli
Pasha, M.K.; Dimmock, J.R.; Hollenberg, M.D.; Sharma, R.K.
Enhanced activity of human N-myristoyltransferase by dimethyl sulfoxide and related solvents in the presence of serine/threonine-containing peptide substrates
Biochem. Pharmacol.
64
1461-1467
2002
Mammalian orthoreovirus 3
Oroszi, G.; Enoch, M.A.; Chun, J.; Virkkunen, M.; Goldman, D.
Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations
Alcohol. Clin. Exp. Res.
29
303-309
2005
BRENDA: Homo sapiens
Textmining: Areas
Grassmann, S.; Apelt, J.; Sippl, W.; Ligneau, X.; Pertz, H.H.; Zhao, Y.H.; Arrang, J.M.; Ganellin, C.R.; Schwartz, J.C.; Schunack, W.; Stark, H.
Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities
Bioorg. Med. Chem.
11
2163-2174
2003
BRENDA: Rattus norvegicus
Textmining: Homo sapiens, Rattus, Areas
Huetz, G.N.; Schwelberger, H.G.
Simultaneous purification of the histamine degrading enzymes diamine oxidase and histamine N-methyltransferase from the same tissue
Inflamm. Res.
52
S65-S66
2003
Sus scrofa
-
Kuefner, M.A.; Schwelberger, H.G.; Weidenhiller, M.; Hahn, E.G.; Raithel, M.
Both catabolic pathways of histamine via histamine-N-methyl-transferase and diamine oxidase are diminished in the colonic mucosa of patients with food allergy
Inflamm. Res.
53
S31-S32
2004
Homo sapiens
-
Taraschenko, O.D.; Barnes, W.G.; Herrick-Davis, K.; Yokoyama, Y.; Boyd, D.L.; Hough, L.B.
Actions of tacrine and galanthamine on histamine-N-methyltransferase
Methods Find. Exp. Clin. Pharmacol.
27
161-165
2005
BRENDA: Homo sapiens, Rattus norvegicus
Textmining: Rodentia, Rattus
Apelt, J.; Grassmann, S.; Ligneau, X.; Pertz, H.H.; Ganellin, C.R.; Arrang, J.M.; Schwartz, J.C.; Schunack, W.; Stark, H.
Search for histamine H3 receptor antagonists with combined inhibitory potency at Ntau-methyltransferase: ether derivatives
Pharmazie
60
97-106
2005
Rattus norvegicus
Feurle, J.; Rajtar, S.; Irman-Florjanc, T.; Schwelberger, H.G.
Molecular cloning of guinea-pig diamine oxidase and histamine N-methyltransferase
Inflamm. Res.
55
S59-S60
2006
Cavia porcellus
-
Horton, J.R.; Sawada, K.; Nishibori, M.; Cheng, X.
Structural basis for inhibition of histamine N-methyltransferase by diverse drugs
J. Mol. Biol.
353
334-344
2005
BRENDA: Homo sapiens (P50135)
Textmining: Mammalia
Aschenbach, J.R.; Schwelberger, H.G.; Ahrens, F.; Fuerll, B.; Gaebel, G.
Histamine inactivation in the colon of pigs in relationship to abundance of catabolic enzymes
Scand. J. Gastroenterol.
41
712-719
2006
BRENDA: Sus scrofa
Textmining: Suidae
Rutherford, K.; Parson, W.W.; Daggett, V.
The histamine N-methyltransferase T105I polymorphism affects active site structure and dynamics
Biochemistry
47
893-901
2008
Homo sapiens (P50135), Homo sapiens
Cao, H.; Mei, Q.; Zhang, L.; Xu, J.
C314T polymorphism in histamine N-methyltransferase gene and susceptibility to duodenal ulcer in Chinese population.
Clin. Chim. Acta
391
130
2008
Homo sapiens
-
Reuter, M.; Jeste, N.; Klein, T.; Hennig, J.; Goldman, D.; Enoch, M.; Oroszi, G.
Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians
Drug Alcohol Depend.
87
69-75
2007
Homo sapiens
Yokoyama, A.; Mori, S.; Takahashi, H.K.; Kanke, T.; Wake, H.; Nishibori, M.
Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice
Eur. J. Pharmacol.
558
179-184
2007
BRENDA: Mus musculus
Textmining: Cutibacterium acnes, Mus sp.
Rajtar, S.; Irman-Florjanc, T.
Amitriptyline affects histamine-N-methyltransferase and diamine oxidase activity in rats and guinea pigs
Eur. J. Pharmacol.
574
201-208
2007
BRENDA: Cavia porcellus, Rattus norvegicus
Textmining: Cavia, Rattus, Rodentia
Ledesma, M.C.; Garcia-Martin, E.; Alonso-Navarro, H.; Martinez, C.; Jimenez-Jimenez, F.J.; Benito-Leon, J.; Puertas, I.; Rubio, L.; Lopez-Alburquerque, T.; Agundez, J.A.
The Nonsynonymous Thr105Ile Polymorphism of the Histamine N-Methyltransferase is Associated to the Risk of Developing Essential Tremor
Neuromolecular Med.
10
356-361
2008
Homo sapiens
Huang, C.C.; Huang, C.W.; Cheng, Y.S.; Yu, J.
Histamine metabolism influences blood vessel branching in zebrafish reg6 mutants
BMC Dev. Biol.
8
31
2008
Danio rerio
Kim, S.H.; Kang, Y.M.; Kim, S.H.; Cho, B.Y.; Ye, Y.M.; Hur, G.Y.; Park, H.S.
Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria
Allergy
64
213-221
2009
Homo sapiens
Dave, S.; Rahatgaonkar, A.
Computational evaluation of 2-phenyl-4H-chromen-4-one analogues as antihistamines: Potential histamine N-methyltransferase (HMT) inhibitors
E-J. Chem.
6
1009-1016
2009
Homo sapiens
-
von Mach-Szczypi?ski, J.; Stanosz, S.; Sieja, K.; Stanosz, M.
Histamine and its metabolizing enzymes in tissues of primary ductal breast cancer
Eur. J. Gynaecol. Oncol.
30
509-511
2009
Homo sapiens
Osredkar, D.; Burnik-Papler, T.; Pecavar, B.; Kralj-Iglic, V.; Krzan, M.
Kinetic and pharmacological properties of [(3)H]-histamine transport into cultured type 1 astrocytes from neonatal rats
Inflamm. Res.
58
94-102
2009
BRENDA: Rattus norvegicus
Textmining: Rattus
Agundez, J.; Luengo, A.; Herraez, O.; Martinez, C.; Alonso-Navarro, H.; Jimenez-Jimenez, F.; Garcia-Martin, E.
Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinsons disease
Neuromolecular Med.
10
10-16
2008
Homo sapiens (P50135), Homo sapiens
Bobenchik, A.M.; Choi, J.Y.; Mishra, A.; Rujan, I.N.; Hao, B.; Voelker, D.R.; Hoch, J.C.; Mamoun, C.B.
Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay
BMC Biochem.
11
4-4
2010
Plasmodium falciparum, Saccharomyces cerevisiae, Anura, Homo sapiens, Nematodes, protozoa
Palada, V.; Terzi?, J.; Mazzulli, J.; Bwala, G.; Hagenah, J.; Peterlin, B.; Hung, A.Y.; Klein, C.; Krainc, D.
Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinsons disease
Neurobiol. Aging
33
836.e1-3
2012
BRENDA: Homo sapiens
Textmining: California
Kuefner, M.A.; Feurle, J.; Petersen, J.; Uder, M.; Schwelberger, H.G.
Influence of iodinated contrast media on the activities of histamine inactivating enzymes diamine oxidase and histamine N-methyltransferase in vitro
Allergol. Immunopathol. (Madr.)
42
324-328
2014
BRENDA: Homo sapiens (P50135), Homo sapiens
Textmining: Sus scrofa
Drozak, J.; Chrobok, L.; Poleszak, O.; Jagielski, A.K.; Derlacz, R.
Molecular identification of carnosine N-methyltransferase as chicken histamine N-methyltransferase-like protein (HNMT-like)
PLoS ONE
8
e64805
2013
Gallus gallus, Gallus gallus (U3NEE3), vertebrata
Tongsook, C.; Niederhauser, J.; Kronegger, E.; Straganz, G.; Macheroux, P.
Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability
Biochim. Biophys. Acta
1863
188-199
2017
Homo sapiens (P50135), Homo sapiens
Jia, H.Z.; Liu, S.L.; Zou, Y.F.; Chen, X.F.; Yu, L.; Wan, J.; Zhang, H.Y.; Chen, Q.; Xiong, Y.; Yu, B.; Zhang, W.
MicroRNA-223 is involved in the pathogenesis of atopic dermatitis by affecting histamine-N-methyltransferase
Cell. Mol. Biol. (Noisy-le-grand)
64
103-107
2018
BRENDA: Homo sapiens (P50135), Homo sapiens
Textmining: Mus sp.
Maw, H.H.; Zeng, X.; Campbell, S.; Taub, M.E.; Teitelbaum, A.M.
N-Methylation of BI 187004 by thiol S-methyltransferase
Drug Metab. Dispos.
46
770-778
2018
Homo sapiens (P50135), Homo sapiens
Naganuma, F.; Nakamura, T.; Yoshikawa, T.; Iida, T.; Miura, Y.; Karpati, A.; Matsuzawa, T.; Yanai, A.; Mogi, A.; Mochizuki, T.; Okamura, N.; Yanai, K.
Histamine N-methyltransferase regulates aggression and the sleep-wake cycle
Sci. Rep.
7
15899
2017
BRENDA: Mus musculus (Q91VF2)
Textmining: Mus sp.
You, X; Tan, S
[A study on activity of beta-glucuronidase in serum and secretion from upper respiratory tract in patients with head and neck malignant tumors]
Zhonghua Er Bi Yan Hou Ke Za Zhi
31
181-4
1996
Homo sapiens
Bischoff, S; Korf, J
Different localization of histidine decarboxylase and histamine-N-methyltransferase in the rat brain.
Brain Res
141
375-9
1978
Rattus
Prast, H; Gujrati, V; Walser, S; Philippu, A
Histamine, histidine decarboxylase and histamine-N-methyltransferase in brain areas of spontaneously hypertensive rats.
Naunyn Schmiedebergs Arch Pharmacol
338
573-6
1988
Rattus, Areas, Metazoa
Snyder, SH; Brown, B; Kuhar, MJ
The subsynaptosomal localization of histamine, histidine decarboxylase and histamine methyltransferase in rat hypothalamus.
J Neurochem
23
37-45
1974
Rattus
Fisher, DZ; Meier, E; Fitzpatrick, D
Histamine, free-histidine concentrations and histidine decarboxylase, histamine methyltransferase activities in developing rat tissues.
Comp Biochem Physiol C
68C
231-4
1981
Rattus
Huszti, Z; Magyar, K
Regulation of histidine decarboxylase activity in rat hypothalamus in vitro by ATP and cyclic AMP: enzyme inactivation under phosphorylating conditions.
Agents Actions
14
546-9
1984
Rattus, Cavia
Lee, NS; Fitzpatrick, D; Meier, E; Fisher, H
Influence of dietary histidine on tissue histamine concentration, histidine decarboxylase and histamine methyltransferase activity in the rat.
Agents Actions
11
307-11
1981
Rattus, Gallus gallus
Peden, NR; Boyd, EJ; Callachan, H; Shepherd, DM; Wormsley, KG
The effects of impromidine and pentagastrin on gastric output of histamine, acid and pepsin in man.
Hepatogastroenterology
29
30-4
1982
Homo sapiens
Saavedra, JM; Brownstein, MJ; Palkovits, M
Distribution of catechol-O-methyltransferase, histamine N-methyltransferase and monoamine oxidase in specific areas of the rat brain.
Brain Res
118
152-6
1976
Rattus, Areas
Hui, JY; Taylor, SL
Inhibition of in vivo histamine metabolism in rats by foodborne and pharmacologic inhibitors of diamine oxidase, histamine N-methyltransferase, and monoamine oxidase.
Toxicol Appl Pharmacol
81
241-9
1985
Rattus
Guzmán, JA; Pelzer, LE; Piezzi, RS; Scardapane, L; Dominguez, S
Hydroxyindole-O-methyltransferase (HIOMT), catechol-O-methyltransferase (COMT) and histamine-N-methyltransferase (HNMT) in the pineal gland of the vizcacha (Lagostomus maximus maximus).
J Neural Transm
47
23-8
1980
Maximus, Rodentia, Metazoa
Bäckström, M; Wetterberg, L
Catechol-O-methyltransferase, histamine-N-methyltransferase and methanol forming enzymes in the rat pineal gland.
Life Sci I
11
293-9
1972
Rattus
Lecklin, A; Tuomisto, L; MacDonald, E
Metoprine, an inhibitor of histamine N-methyltransferase but not catechol-O-methyltransferase, suppresses feeding in sated and in food deprived rats.
Methods Find Exp Clin Pharmacol
17
47-52
0
Rattus
Sellinger, OZ; Schatz, RA; Ohlsson, WG
Rat and mouse brain histamine N-methyltransferase: modulation by methylated indoleamines.
J Neurochem
30
437-45
1978
Mus musculus, Rattus
Orr, EL; Quay, WB
Product inhibition of rat brain histamine-N-methyltransferase.
J Neurochem
30
1539-42
1978
Rattus
Tuomisto, L
Ontogenesis and regional distribution of histamine and histamine-N-methyltransferase in the guinea pig brain.
J Neurochem
28
271-6
1977
Cavia porcellus
Barth, H; Troidl, H; Lorenz, W; Rohde, H; Glass, R
Histamine and peptic ulcer disease: histamine methyltransferase activity in gastric mucosa of control subjects and duodenal ulcer patients before and after surgical treatment.
Agents Actions
7
75-9
1977
Homo sapiens
Kouvelas, ED; Savakis, CE; Tzebelikos, ET; Bonatsos, G; Mitrossilis, S
Developmental characteristics of histamine methyltransferase and phenylethanolamine-N-methyl-transferase of rat brain.
Experientia
32
1136-8
1976
Rattus
Barth, H; Naber, K; Barthel, KE; Niemeyer, I; Lorenz, W
Induction of histamine methyltransferase during experimental hydronephrosis: a mechanism of adaptation for histamine homeostasis in rabbit kidney.
Agents Actions
5
442-3
1975
Oryctolagus cuniculus
Ohrui, T; Yamauchi, K; Sekizawa, K; Ohkawara, Y; Maeyama, K; Sasaki, M; Takemura, M; Wada, H; Watanabe, T; Sasaki, H
Histamine N-methyltransferase controls the contractile response of guinea pig trachea to histamine.
J Pharmacol Exp Ther
261
1268-72
1992
Cavia porcellus, Trachea
Takemura, M; Tanaka, T; Taguchi, Y; Imamura, I; Mizuguchi, H; Kuroda, M; Fukui, H; Yamatodani, A; Wada, H
Histamine N-methyltransferase from rat kidney. Cloning, nucleotide sequence, and expression in Escherichia coli cells.
J Biol Chem
267
15687-91
1992
Escherichia, Escherichia coli, Rattus
Cumming, P; Reiner, PB; Vincent, SR
Inhibition of rat brain histamine-N-methyltransferase by 9-amino-1,2,3,4-tetrahydroacridine (THA).
Biochem Pharmacol
40
1345-50
1990
Rattus
Verburg, KM; Bowsher, RR; Zerbe, RL; Henry, DP
The effect of hypertonic saline administration or stalk transection on histamine and histamine N-methyltransferase in the rat posterior pituitary.
Agents Actions
18
494-8
1986
Rattus
Loiselle, J; Wollin, A
Histamine methyltransferase in dispersed cells from rabbit fundic mucosa.
Agents Actions
28
39-44
1989
Oryctolagus cuniculus
Tachibana, T; Taniguchi, S; Imamura, S; Fujiwara, M; Hayashi, H
Effects of drugs on the activity of histamine-N-methyltransferase from guinea pig skin.
Biochem Pharmacol
37
2872-6
1988
Cavia porcellus
Gairola, C; Godin, CS; Houdi, AA; Crooks, PA
Inhibition of histamine N-methyltransferase activity in guinea-pig pulmonary alveolar macrophages by nicotine.
J Pharm Pharmacol
40
724-6
1988
Cavia porcellus
Harle, DG; Baldo, BA
Structural features of potent inhibitors of rat kidney histamine N-methyltransferase.
Biochem Pharmacol
37
385-8
1988
Rattus
Scott, MC; Van Loon, JA; Weinshilboum, RM
Pharmacogenetics of N-methylation: heritability of human erythrocyte histamine N-methyltransferase activity.
Clin Pharmacol Ther
43
256-62
1988
Homo sapiens
Furukawa, F; Taniguchi, S; Tachibana, T; Horiguchi, Y; Kanauchi, H; Ohshio, G; Hamashima, Y; Imamura, S
Pathogenesis of lupus dermatoses in autoimmune mice. X. Evaluation of histamine-N-methyltransferase activity in the skin of autoimmune.
Microbiol Immunol
32
83-96
1988
Mus sp., Mus musculus
Tachibana, T; Taniguchi, S; Fujiwara, M; Imamura, S
Regulation of the activity of histamine-N-methyltransferase from guinea pig skin by biogenic amines.
Exp Mol Pathol
45
257-69
1986
Cavia porcellus
Van Loon, JA; Pazmiño, PA; Weinshilboum, RM
Human erythrocyte histamine N-methyltransferase: radiochemical microassay and biochemical properties.
Clin Chim Acta
149
237-51
1985
Homo sapiens
Troidl, H; Lorenz, W; Barth, H; Rohde, H; Feifel, G; Schmal, A; Goecke, K; Reimann-Huhnd, A; Seidel, W
Augmentation of pentagastrin stimulated gastric secretion in the Heidenhain pouch dog by amodiaquine: inhibition of histamine methyltransferase in vivo?
Agents Actions
3
157-87
1973
Canis lupus familiaris
Lorenz, W; Barth, H; Werle, E
Histamine and histamine methyltransferase in the gastric mucosa of man, pig, dog and cow.
Naunyn Schmiedebergs Arch Pharmakol
267
421-32
1970
Homo sapiens, Canis lupus familiaris, Sus scrofa, Bos taurus
Lorenz, W; Barth, H; Feifel, G; Werle, E
Histamine methyltransferase in salivary glands and gastric mucosa of man, dog, pig and cow.
Naunyn Schmiedebergs Arch Pharmakol
266
395-6
1970
Homo sapiens, Canis lupus familiaris, Sus scrofa, Bos taurus
Kuhar, MJ; Taylor, KM; Snyder, SH
The subcellular localization of histamine and histamine methyltransferase in rat brain.
J Neurochem
18
1515-27
1971
Rattus
Hesterberg, R; Sattler, J; Lorenz, W; Stahlknecht, CD; Barth, H; Crombach, M; Weber, D
Histamine content, diamine oxidase activity and histamine methyltransferase activity in human tissues: fact or fictions?
Agents Actions
14
325-34
1984
Homo sapiens
Tuomisto, L; Kilpeläinen, H; Riekkinen, P
Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis.
Agents Actions
13
255-7
1983
Homo sapiens
Tuomisto, L; Tuomisto, J
Diurnal variations in brain and pituitary histamine and histamine-N-methyltransferase in the rat and guinea pig.
Med Biol
60
204-9
1982
Rattus, Cavia porcellus
Tuomisto, L; Eriksson, L
Histamine and histamine-N-methyltransferase in the goat brain.
Agents Actions
12
142-5
1982
animal, Capra hircus
Sperk, G; Hörtnagl, H; Reither, H; Hornykiewicz, O
Evidence for neuronal localization of histamine-N-methyltransferase in rat brain.
J Neurochem
37
525-6
1981
Rattus
Okayama, M; Yamauchi, K; Sekizawa, K; Okayama, H; Sasaki, H; Inamura, N; Maeyama, K; Watanabe, T; Takishima, T; Shirato, K
Localization of histamine N-methyltransferase messenger RNA in human nasal mucosa.
J Allergy Clin Immunol
95
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1995
Homo sapiens
Girard, B; Otterness, DM; Wood, TC; Honchel, R; Wieben, ED; Weinshilboum, RM
Human histamine N-methyltransferase pharmacogenetics: cloning and expression of kidney cDNA.
Mol Pharmacol
45
461-8
1994
Homo sapiens, Rattus, Oryctolagus cuniculus
Nakazawa, H; Sekizawa, K; Morikawa, M; Yamauchi, K; Satoh, M; Maeyama, K; Watanabe, T; Sasaki, H
Viral respiratory infection causes airway hyperresponsiveness and decreases histamine N-methyltransferase activity in guinea pigs.
Am J Respir Crit Care Med
149
1180-5
1994
Cavia, Murine respirovirus, Metazoa, Trachea
Sekizawa, K; Nakazawa, H; Ohrui, T; Yamauchi, K; Ohkawara, Y; Maeyama, K; Watanabe, T; Sasaki, H; Takishima, T
Histamine N-methyltransferase modulates histamine- and antigen-induced bronchoconstriction in guinea pigs in vivo.
Am Rev Respir Dis
147
92-6
1993
Cavia, Trachea
Hoshi, H; Yamauchi, K; Sekizawa, K; Ohkawara, Y; Iijima, H; Sakurai, E; Maeda, K; Okinaga, S; Ohno, I; Honma, M; Tamura, G; Tanno, Y; Watanabe, T; Sasaki, H; Shirato, K
Nitrogen dioxide exposure increases airway contractile response to histamine by decreasing histamine N-methyltransferase activity in guinea pigs.
Am J Respir Cell Mol Biol
14
76-83
1996
Cavia, Cavia porcellus, Trachea
Sekizawa, K; Nakazawa, H; Morikawa, M; Yamauchi, K; Maeyama, K; Watanabe, T; Sasaki, H
Histamine N-methyltransferase inhibitor potentiates histamine- and antigen-induced airway microvascular leakage in guinea pigs.
J Allergy Clin Immunol
96
910-6
1995
Cavia, Trachea
Aksoy, S; Raftogianis, R; Weinshilboum, R
Human histamine N-methyltransferase gene: structural characterization and chromosomal location.
Biochem Biophys Res Commun
219
548-54
1996
Homo sapiens
Malmberg-Aiello, P; Lamberti, C; Ipponi, A; Hänninen, J; Ghelardini, C; Bartolini, A
Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301 U, in rodent antinociception.
Naunyn Schmiedebergs Arch Pharmacol
355
354-60
1997
Rodentia, Mus sp., Rattus, animal
De Santi, C; Donatelli, P; Giulianotti, PC; Pietrabissa, A; Mosca, F; Pacifici, GM
Interindividual variability of histamine N-methyltransferase in the human liver and kidney.
Xenobiotica
28
571-7
1998
Homo sapiens
Nishibori, M; Tahara, A; Sawada, K; Sakiyama, J; Nakaya, N; Saeki, K
Neuronal and vascular localization of histamine N-methyltransferase in the bovine central nervous system.
Eur J Neurosci
12
415-24
2000
Bos taurus
Kitanaka, J; Kitanaka, N; Tsujimura, T; Kakihana, M; Terada, N; Takemura, M
Guinea pig histamine N-methyltransferase: cDNA cloning and mRNA distribution.
Jpn J Pharmacol
85
105-8
2001
Cavia porcellus, Homo sapiens, Rattus
Kitanaka, J; Kitanaka, N; Tsujimura, T; Terada, N; Takemura, M
Histamine N-methyltransferase regulates histamine-induced phosphoinositide hydrolysis in guinea pig cerebellum.
Neurosci Lett
308
5-8
2001
Cavia porcellus
Wang, L; Yan, L; McGuire, C; Kozak, CA; Wang, M; Kim, UJ; Siciliano, M; Weinshilboum, RM
Mouse histamine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization.
Inflamm Res
50
300-8
2001
Mus musculus, Homo sapiens
Kitanaka, N; Kitanaka, J; Oue, T; Tada, Y; Tanaka, T; Takemura, M
Genomic structure of the rat and mouse histamine N-methyltransferase gene.
Jpn J Pharmacol
88
85-92
2002
Mus musculus, Rattus, Mus sp.
Kim, SH; Krapfenbauer, K; Cheon, MS; Fountoulakis, M; Cairns, NJ; Lubec, G
Human brain cytosolic histamine-N-methyltransferase is decreased in Down syndrome and increased in Pick's disease.
Neurosci Lett
321
169-72
2002
Homo sapiens
Schwelberger, HG; Drasche, A
Structure and expression of porcine histamine N-methyltransferase.
Inflamm Res
51 Suppl 1
S85-6
2002
Sus scrofa
Petersen, J; Raithel, M; Schwelberger, HG
Histamine N-methyltransferase and diamine oxidase gene polymorphisms in patients with inflammatory and neoplastic intestinal diseases.
Inflamm Res
51 Suppl 1
S91-2
2002
Homo sapiens
Wang, L; Thomae, B; Eckloff, B; Wieben, E; Weinshilboum, R
Human histamine N-methyltransferase pharmacogenetics: gene resequencing, promoter characterization, and functional studies of a common 5'-flanking region single nucleotide polymorphism (SNP).
Biochem Pharmacol
64
699-710
2002
Homo sapiens
Barnes, WG; Hough, LB
Membrane-bound histamine N-methyltransferase in mouse brain: possible role in the synaptic inactivation of neuronal histamine.
J Neurochem
82
1262-71
2002
Mus musculus
Jochem, J; Zwirska-Korczala, K; Rybus-Kalinowska, B; Jagodzińska, J; Korzonek-Szlacheta, I
Influence of SKF 91488, histamine N-methyltransferase inhibitor, on the central cardiovascular regulation during controlled, stepwise hemorrhagic hypotension in rats.
Pol J Pharmacol
54
237-44
0
Rattus, Metazoa
Barnes, WG; Grinde, E; Crawford, DR; Herrick-Davis, K; Hough, LB
Characterization of a new mRNA species from the human histamine N-methyltransferase gene.
Genomics
83
168-71
2004
Homo sapiens
Kuefner, MA; Schwelberger, HG; Weidenhiller, M; Hahn, EG; Raithel, M
Both catabolic pathways of histamine via histamine-N-methyltransferase and diamine oxidase are diminished in the colonic mucosa of patients with food allergy.
Inflamm Res
53 Suppl 1
S31-2
2004
Homo sapiens
Jochem, J
Cardiac and regional haemodynamic effects of histamine N-methyltransferase inhibitor metoprine in haemorrhage-shocked rats.
Inflamm Res
53
316-23
2004
Rattus, Rattus norvegicus, Metazoa
Chen, GL; Zhu, B; Nie, WP; Xu, ZH; Tan, ZR; Zhou, G; Liu, J; Wang, W; Zhou, HH
Single nucleotide polymorphisms and haplotypes of histamine N-methyltransferase in patients with gastric ulcer.
Inflamm Res
53
484-8
2004
Homo sapiens
Feurle, J; Rajtar, S; Irman-Florjanc, T; Schwelberger, HG
Molecular cloning of guinea-pig diamine oxidase and histamine N-methyltransferase.
Inflamm Res
55 Suppl 1
S59-60
2006
Cavia porcellus
Tamaoki, J; Chiyotani, A; Tagaya, E; Isono, K; Konno, K
Histamine N-methyltransferase Modulates Human Bronchial Smooth Muscle Contraction.
Mediators Inflamm
3
125-9
1994
Homo sapiens
Kennedy, MJ; Loehle, JA; Griffin, AR; Doll, MA; Kearns, GL; Sullivan, JE; Hein, DW
Association of the histamine N-methyltransferase C314T (Thr105Ile) polymorphism with atopic dermatitis in Caucasian children.
Pharmacotherapy
28
1495-501
2008
Homo sapiens
Lee, HS; Kim, SH; Kim, KW; Baek, JY; Park, HS; Lee, KE; Hong, JY; Kim, MN; Heo, WI; Sohn, MH; Kim, KE
Involvement of human histamine N-methyltransferase gene polymorphisms in susceptibility to atopic dermatitis in korean children.
Allergy Asthma Immunol Res
4
31-6
2012
Homo sapiens
Meza-Velázquez, R; López-Márquez, F; Espinosa-Padilla, S; Rivera-Guillen, M; Ávila-Hernández, J; Rosales-González, M
Association of diamine oxidase and histamine N-methyltransferase polymorphisms with presence of migraine in a group of Mexican mothers of children with allergies.
Neurologia
2016
Homo sapiens
Schwelberger, HG; Feurle, J; Houen, G
Monoclonal antibodies for human and porcine histamine N-methyltransferase (HMT) facilitate protein expression and localization studies.
Inflamm Res
2016
Homo sapiens, Sus scrofa, Mammalia
Schwelberger, HG; Feurle, J; Houen, G
Mapping of the binding sites of human histamine N-methyltransferase (HNMT) monoclonal antibodies.
Inflamm Res
2017
Homo sapiens, Mus musculus
Nurhan, AD; Gani, MA; Budiatin, AS; Siswodihardjo, S; Khotib, J
Molecular docking studies of Nigella sativa L and Curcuma xanthorrhiza Roxb secondary metabolites against histamine N-methyltransferase with their ADMET prediction.
J Basic Clin Physiol Pharmacol
32
795-802
2021
Curcuma xanthorrhiza, Nigella sativa
Kitanaka, N; Hall, FS; Kobori, S; Kushihara, S; Oyama, H; Sasaoka, Y; Takechi, M; Tanaka, KI; Tomita, K; Igarashi, K; Nishiyama, N; Sato, T; Uhl, GR; Kitanaka, J
Metoprine, a histamine N-methyltransferase inhibitor, attenuates methamphetamine-induced hyperlocomotion via activation of histaminergic neurotransmission in mice.
Pharmacol Biochem Behav
209
173257
2021
Mus sp.
The kinetic properties and reaction mechanism of histamine methyltransferase from human skin.
The Biochemical journal
191
899-899
1980
Homo sapiens
Gastric mucosal histamine and histamine methyltransferase in patients with duodenal ulcer.
Gut
23
356-356
1982
Homo sapiens
Rocque, WJ; McWherter, CA; Wood, DC; Gordon, JI
A comparative analysis of the kinetic mechanism and peptide substrate specificity of human and Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase.
J Biol Chem
268
9964-71
1993
Homo sapiens, Orthoreovirus
Raju, RV; Datla, RS; Sharma, RK
Overexpression of human N-myristoyltransferase utilizing a T7 polymerase gene expression system.
Protein Expr Purif
7
431-7
1996
Escherichia
Glover, CJ; Hartman, KD; Felsted, RL
Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction.
J Biol Chem
272
28680-9
1997
plasmids
Herman, KS; Bowsher, RR; Henry, DP
Synthesis of N pi-methylhistamine and N alpha-methylhistamine by purified rabbit lung indolethylamine N-methyltransferase.
J Biol Chem
260
12336-40
1985
Oryctolagus cuniculus, Mammalia
Zeiger, RS; Yurdin, DL; Colten, HR
Histamine metabolism. II. Cellular and subcellular localization of the catabolic enzymes, histaminase and histamine methyl transferase, in human leukocytes.
J Allergy Clin Immunol
58
172-9
1976
Homo sapiens
Kitanaka, J; Kitanaka, N; Tsujimura, T; Terada, N; Takemura, M
Expression of diamine oxidase (histaminase) in guinea-pig tissues.
Eur J Pharmacol
437
179-85
2002
Cavia porcellus
Bergmark, J; Granerus, G; Henningsson, S; Lundell, L; Rosengren, E
Histamine metabolism of the guinea-pig gastric mucosa.
J Physiol
257
419-31
1976
Cavia porcellus, Cavia
Adachi, N; Itoh, Y; Oishi, R; Saeki, K
Direct evidence for increased continuous histamine release in the striatum of conscious freely moving rats produced by middle cerebral artery occlusion.
J Cereb Blood Flow Metab
12
477-83
1992
Rattus
Sakai, N; Onodera, K; Maeyama, K; Yanai, K; Watanabe, T
Effects of (S)-alpha -fluoromethylhistidine and metoprine on locomotor activity and brain histamine content in mice.
Life Sci
51
397-405
1992
Mus sp.
Lönroth, H; Rosengren, E; Lundell, L
The role of the antrum and the vagus nerve in the metabolism of histamine in the human gastric mucosa.
Scand J Gastroenterol
26
827-38
1991
Areas, Homo sapiens
Waśkiewicz, J; Wałajtys-Rode, E; Rafałowska, U
Effect of hyperoxia on histamine metabolism in rat brain synaptosomes: preliminary observations.
Neuropatol Pol
29
79-85
1991
Rattus, Rattus norvegicus
Abe, Y; Ogino, S; Irifune, M; Matsunaga, T; Imamura, I; Fukui, H; Wada, H
[Histamine metabolism in the nasal tissue of human and nasal hypersensitive guinea-pig]
Nippon Jibiinkoka Gakkai Kaiho
94
1113-22
1991
Homo sapiens, Cavia, Cavia porcellus
Fogel, WA; Andrzejewski, W; Maslinski, C
Brain histamine in rats with hepatic encephalopathy.
J Neurochem
56
38-43
1991
Rattus, Rattus norvegicus
Muroi, N; Oishi, R; Saeki, K
Effect of reserpine on histamine metabolism in the mouse brain.
J Pharmacol Exp Ther
256
967-72
1991
Mus musculus, Mus sp.
Lönroth, H; Rosengren, E; Olbe, L; Lundell, L
Histamine metabolism in human gastric mucosa. Effect of pentagastrin stimulation.
Gastroenterology
98
921-8
1990
Areas, Homo sapiens
Wałajtys-Rode, E; Waśkiewicz, J; Rafałowska, U
Effect of in vivo glucocorticoid administration on histamine metabolism in rat brain synaptosomes.
Neurosci Lett
97
340-4
1989
Rattus
Beaven, MA; Soll, AH; Lewin, KJ
Histamine synthesis by intact mast cells from canine fundic mucosa and liver.
Gastroenterology
82
254-62
1982
Canis lupus familiaris, Rattus
Subramanian, N; Schinzel, W; Mitznegg, P; Estler, CJ
Influence of ethanol on histamine metabolism and release in the rat brain. II. Regions of the histaminergic pathway.
Pharmacology
20
42-5
1980
Rattus
Abe, Y; Ogino, S; Irifune, M; Imamura, I; Liu, YQ; Fukui, H; Matsunaga, T
Histamine content, synthesis and degradation in nasal mucosa and lung of guinea-pigs treated with toluene diisocyanate (TDI).
Clin Exp Allergy
23
512-7
1993
Homo sapiens, Cavia, animal
Abe, Y; Ogino, S; Irifune, M; Imamura, I; Fukui, H; Wada, H; Matsunaga, T
Histamine content, synthesis and degradation in human nasal mucosa.
Clin Exp Allergy
23
132-6
1993
Homo sapiens
Tuominen, RK; Tuomisto, L; Männistö, PT
Effect of modified brain histamine contents on prolactin and thyrotropin secretion in male rats.
Eur J Endocrinol
134
209-14
1996
Rattus
Valen, G; Kaszaki, J; Szabo, I; Nagy, S; Vaage, J
Activity of histamine metabolizing and catabolizing enzymes during reperfusion of isolated, globally ischemic rat hearts.
Inflamm Res
45
145-9
1996
Rattus
Darvas, Z; Sakurai, E; Schwelberger, HG; Hegyesi, H; Rivera, E; Othsu, H; Watanabe, T; Pállinger, E; Falus, A
Autonomous histamine metabolism in human melanoma cells.
Melanoma Res
13
239-46
2003
Homo sapiens
Yawata, I; Tanaka, K; Nakagawa, Y; Watanabe, Y; Murashima, YL; Nakano, K
Role of histaminergic neurons in development of epileptic seizures in EL mice.
Brain Res Mol Brain Res
132
13-7
2004
Mus sp., Mus musculus, animal
Arbonés, L; García-Verdugo, J; Picatoste, F; García, A
Presence and distribution of histaminergic components in rat and bovine retina.
Neurochem Int
13
97-104
1988
Bos taurus, Rattus
Rozov, SV; Zant, JC; Karlstedt, K; Porkka-Heiskanen, T; Panula, P
Periodic properties of the histaminergic system of the mouse brain.
Eur J Neurosci
39
218-28
2014
Mus musculus, Mus sp.
Iida, T; Yoshikawa, T; Matsuzawa, T; Naganuma, F; Nakamura, T; Miura, Y; Mohsen, AS; Harada, R; Iwata, R; Yanai, K
Histamine H3 receptor in primary mouse microglia inhibits chemotaxis, phagocytosis, and cytokine secretion.
Glia
2015
Mus musculus
Roh, T; Kwak, MY; Kwak, EH; Kim, DH; Han, EY; Bae, JY; Bang, du Y; Lim, DS; Ahn, IY; Jang, DE; Lim, SK; Yoo, SD; Kwack, SJ; Park, KL; Lee, YJ; Kim, KB; Lee, J; Kim, HS; Lee, BM
Chemopreventive mechanisms of methionine on inhibition of benzo(a)pyrene-DNA adducts formation in human hepatocellular carcinoma HepG2 cells.
Toxicol Lett
208
232-8
2012
Homo sapiens
Jochem, J
Involvement of the renin-angiotensin system in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats.
J Physiol Pharmacol
55
39-55
2004
Rattus, Rattus norvegicus, Metazoa
Lecklin, A; Eriksson, L; Leppäluoto, J; Tarhanen, J; Tuomisto, L
Metoprine-induced thirst and diuresis in Wistar rats.
Acta Physiol Scand
165
325-33
1999
Rattus, Rattus norvegicus
Fogel, WA; Dastych, J; Maśliński, C
The response of histamine degrading enzymes to nematode infection.
Agents Actions
23
304-6
1988
Mus sp., Nippostrongylus brasiliensis, Nematoda
Doyle, RL; Sellinger, OZ
Differences in activity in cerebral methyltransferases and monoamine oxidases between audiogenic seizure susceptible and resistant mice and deermice.
Pharmacol Biochem Behav
13
589-91
1980
animal, Metazoa, Mus musculus, Mus sp., Peromyscus
Bruce, C; Taylor, WH; Westwood, A
An improved radioenzymatic assay for histamine in human plasma, whole blood, urine, and gastric juice.
Ann Clin Biochem
16
259-64
1979
Sus scrofa, Homo sapiens
Laduron, P; Janssen, PF; Aerts, G; Leysen, J
Ontogenetic development of a 5-methyltetrahydrofolate requiring enzyme in rats and mice.
Naunyn Schmiedebergs Arch Pharmacol
286
379-87
1975
Rattus, Mus musculus
Taylor, KM; Randall, PK
Depletion of S-adenosyl-L-methionine in mouse brain by antidepressive drugs.
J Pharmacol Exp Ther
194
303-10
1975
Mus musculus
Rautschka, R; Stanek, C; Knezevic, PF
Plasma histamine levels in laminitic horses and in horses treated with a corticosteroid.
Zentralbl Veterinarmed A
38
716-9
1991
Equidae
Kim, YY; Holgate, ST; Church, MK
Inhibition of histamine release from dispersed human lung and tonsillar mast cells by nicardipine and nifedipine.
Br J Clin Pharmacol
19
631-8
1985
Rattus
Man, WK; Thompson, JN; Baron, JH; Spencer, J
Histamine and duodenal ulcer: effect of omeprazole on gastric histamine in patients with duodenal ulcer.
Gut
27
418-22
1986
Homo sapiens
Mazurkiewicz-Kwilecki, IM; Prell, GD
Brain histamine response to stress in 12 month old rats.
Life Sci
38
2339-45
1986
Rattus
Jacobs, R; Kaliner, M; Shelhamer, JH; Parrillo, JE
Blood histamine concentrations are not elevated in humans with septic shock.
Crit Care Med
17
30-5
1989
Homo sapiens
Kierska, D; Sasiak, K; Biegański, T; Maśliński, C
Causal relationship between a tumour growth and the changes in histamine metabolism in tissues of sarcoma-bearing rat.
Agents Actions
20
314-6
1987
Rattus, Rattus norvegicus
Imamura, S; Tachibana, T; Taniguchi, S
Impaired histamine metabolism in the Arthus reaction induced in guinea-pig skin.
Arch Dermatol Res
277
313-7
1985
Cavia, Cavia porcellus, Metazoa, Areas
Hough, LB; Jackowski, S; Eberle, N; Gogas, KR; Camarota, NA; Cue, D
Actions of the brain-penetrating H2-antagonist zolantidine on histamine dynamics and metabolism in rat brain.
Biochem Pharmacol
37
4707-11
1988
Rattus, Metazoa
Kierska, D; Sasiak, K; Maslinski, C
Influence of pyridoxal 5'-phosphate on ethanol-induced changes in histamine catabolism in the guinea pig.
Alcohol Alcohol
22
389-94
1987
Cavia porcellus, Cavia
Fukuda, H; Kiyama, H; Maeyama, K; Kubota, H; Yamatodani, A; Watanabe, T; Tohyama, M; Wada, H
Immunohistochemical demonstration of histamine N-methyltransferase-like structures in rat kidney.
Cell Tissue Res
243
681-4
1986
Rattus, Cavia, Sus scrofa, Capra hircus
Zawilska, J; Nowak, JZ
Changes in the rat brain histamine content following metoprine and other histamine-methyltransferase (HMT) inhibitors.
Pol J Pharmacol Pharm
37
821-30
0
Rattus
Tachibana, T; Furukawa, F; Taniguchi, S; Hamashima, Y; Imamura, S
Histamine metabolism in skin of MRL/l mice.
Arch Dermatol Res
278
57-60
1985
Mus sp., Mus musculus
Peden, NR; Callachan, H; Shepherd, DM; Wormsley, KG
Gastric mucosal histamine and histamine methytltransferase in patients with duodenal ulcer.
Gut
23
58-62
1982
Homo sapiens
Robinson-White, A; Beaven, MA
Presence of histamine and histamine-metabolizing enzyme in rat and guinea-pig microvascular endothelial cells.
J Pharmacol Exp Ther
223
440-5
1982
Cavia porcellus, Rattus
Fleckenstein, AE; Lookingland, KJ; Moore, KE
Effects of histamine on 5-hydroxytryptaminergic neuronal activity in the rat hypothalamus.
Eur J Pharmacol
254
35-42
1994
Rattus
Loiselle, J; Wollin, A
Mucosal histamine elimination and its effect on acid secretion in rabbit gastric mucosa.
Gastroenterology
104
1013-20
1993
Oryctolagus cuniculus
Irman-Florjanc, T; Erjavec, F
Histamine and tele-methylhistamine in cat plasma after intravenous injection of histamine.
Agents Actions
41 Spec No
C129-30
1994
Felis catus, Metazoa
Yamada, K; Shimura, S; Satoh, M; Sasaki, T; Yamauchi, K; Takishima, T
HMT regulates histamine-induced Cl- secretion across the canine tracheal epithelium.
Respir Physiol
97
105-9
1994
Canis lupus familiaris, Trachea
Ito, C; Onodera, K; Sakurai, E; Sato, M; Watanabe, T
Effect of cocaine on the histaminergic neuron system in the rat brain.
J Neurochem
69
875-8
1997
Rattus
Irokawa, T; Nagaki, M; Shimura, S; Sasaki, T; Yamaya, M; Yamauchi, K; Shirato, K
HMT regulates histamine-induced glycoconjugate secretion from human airways in vitro.
Respir Physiol
108
233-40
1997
Homo sapiens
Ito, C; Shen, H; Toyota, H; Kubota, Y; Sakurai, E; Watanabe, T; Sato, M
Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat.
Neurosci Lett
262
143-5
1999
Rattus
Malmberg-Aiello, P; Ipponi, A; Bartolini, A; Schunack, W
Antiamnesic effect of metoprine and of selective histamine H(1) receptor agonists in a modified mouse passive avoidance test.
Neurosci Lett
288
1-4
2000
Mus musculus
Saito, S; Iida, A; Sekine, A; Miura, Y; Sakamoto, T; Ogawa, C; Kawauchi, S; Higuchi, S; Nakamura, Y
Identification of 197 genetic variations in six human methyltranferase genes in the Japanese population.
J Hum Genet
46
529-37
2001
Homo sapiens
Aschenbach, JR; Ahrens, F; Garz, B; Gäbel, G
Paracellular tightness and catabolism restrict histamine permeation in the proximal colon of pigs.
Pflugers Arch
445
115-22
2002
Sus scrofa, Suidae
Jochem, J
Involvement of the sympathetic nervous system in the reversal of critical haemorrhagic hypotension by endogenous central histamine in rats.
Naunyn Schmiedebergs Arch Pharmacol
369
418-27
2004
Rattus, Rattus norvegicus, Metazoa
Jochem, J
Involvement of proopiomenalocortin-derived peptides in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats.
J Physiol Pharmacol
55
57-71
2004
Rattus
Jochem, J
Involvement of arginine vasopressin in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats.
Inflamm Res
53
269-76
2004
Rattus
Motoki, A; Adachi, N; Semba, K; Liu, K; Arai, T
Reduction in brain infarction by augmentation of central histaminergic activity in rats.
Brain Res
1066
172-8
2005
Rattus
Vinogradova, LV; Shatskova, AB; Tuomisto, L
Histaminergic modulation of acoustically induced running behavior in rats.
Brain Res
1148
198-204
2007
Rattus, Rodentia, Rattus norvegicus
Kuefner, MA; Schwelberger, HG; Hahn, EG; Raithel, M
Decreased histamine catabolism in the colonic mucosa of patients with colonic adenoma.
Dig Dis Sci
53
436-42
2008
Homo sapiens
Kitanaka, J; Kitanaka, N; Tatsuta, T; Morita, Y; Takemura, M
Blockade of brain histamine metabolism alters methamphetamine-induced expression pattern of stereotypy in mice via histamine H1 receptors.
Neuroscience
147
765-77
2007
Mus sp.
Takamune, N; Gota, K; Misumi, S; Tanaka, K; Okinaka, S; Shoji, S
HIV-1 production is specifically associated with human NMT1 long form in human NMT isozymes.
Microbes Infect
10
143-50
2008
Homo sapiens, Human immunodeficiency virus 1, Human Immunodeficiency Virus
Furukawa, F; Yoshimasu, T; Yamamoto, Y; Kanazawa, N; Tachibana, T
Mast cells and histamine metabolism in skin lesions from MRL/MP-lpr/lpr mice.
Autoimmun Rev
2009
Mus sp., Homo sapiens, Mus musculus
Aschenbach, JR; Honscha, KU; von Vietinghoff, V; Gäbel, G
Bioelimination of histamine in epithelia of the porcine proximal colon of pigs.
Inflamm Res
58
269-76
2009
Suidae, Sus scrofa
Shan, L; Bossers, K; Luchetti, S; Balesar, R; Lethbridge, N; Chazot, PL; Bao, AM; Swaab, DF
Alterations in the histaminergic system in the substantia nigra and striatum of Parkinson's patients: a postmortem study.
Neurobiol Aging
2011
Homo sapiens
Samotaeva, IS; Birioukova, LM; Midzyanovskaya, IS; Kuznetsova, GD; Bazyan, AS; Tuomisto, L
Metoprine induced behavioral modifications and brain regional histamine increase in WAG/Rij and Wistar rats.
Epilepsy Res
101
148-56
2012
Rattus
Yoshikawa, T; Naganuma, F; Iida, T; Nakamura, T; Harada, R; Mohsen, AS; Kasajima, A; Sasano, H; Yanai, K
Molecular mechanism of histamine clearance by primary human astrocytes.
Glia
2013
Homo sapiens, Rodentia
Tomita, Y; Yuno, A; Tsukamoto, H; Senju, S; Kuroda, Y; Hirayama, M; Imamura, Y; Yatsuda, J; Sayem, MA; Irie, A; Hamada, A; Jono, H; Yoshida, K; Tsunoda, T; Daigo, Y; Kohrogi, H; Yoshitake, Y; Nakamura, Y; Shinohara, M; Nishimura, Y
Identification of immunogenic LY6K long peptide encompassing both CD4(+) and CD8(+) T-cell epitopes and eliciting CD4(+) T-cell immunity in patients with malignant disease.
Oncoimmunology
3
e28100
2014
Homo sapiens
Anvari, S; Vyhlidal, CA; Dai, H; Jones, BL
Genetic Variation along the Histamine Pathway in Children with Allergic versus Nonallergic Asthma.
Am J Respir Cell Mol Biol
53
802-9
2015
Homo sapiens
Jones, BL; Sherwin, CM; Liu, X; Dai, H; Vyhlidal, CA
Genetic Variation in the Histamine Production, Response, and Degradation Pathway Is Associated with Histamine Pharmacodynamic Response in Children with Asthma.
Front Pharmacol
7
524
2016
Homo sapiens
Krick, CM; Argstatter, H; Grapp, M; Plinkert, PK; Reith, W
Heidelberg Neuro-Music Therapy Enhances Task-Negative Activity in Tinnitus Patients.
Front Neurosci
11
384
2017
Homo sapiens, Areas
Krick, CM; Argstatter, H; Grapp, M; Plinkert, PK; Reith, W
Heidelberg Neuro-Music Therapy Restores Attention-Related Activity in the Angular Gyrus in Chronic Tinnitus Patients.
Front Neurosci
11
418
2017
Homo sapiens
Orr, E; Quay, WB
Hypothalamic 24-hour rhythms in histamine, histidine, decarboxylase and histamine-N-methyltransferase.
Endocrinology
96
941-5
1975
Rattus
Yamauchi, K
[Regulation of gene expression of L-histidine decarboxylase and histamine N-methyl-transferase, and its relevance to the pathogenesis of bronchial asthma]
Nippon Rinsho
54
377-88
1996
Homo sapiens, Mammalia
Hirata, N; Takeuchi, K; Ukai, K; Sakakura, Y
Expression of histidine decarboxylase messenger RNA and histamine N-methyltransferase messenger RNA in nasal allergy.
Clin Exp Allergy
29
76-83
1999
Homo sapiens
He, GH; Lin, JJ; Cai, WK; Xu, WM; Yu, ZP; Yin, SJ; Zhao, CH; Xu, GL
Associations of polymorphisms in histidine decarboxylase, histamine N-methyltransferase and histamine receptor H3 genes with breast cancer.
PLoS One
9
e97728
2014
Homo sapiens
BoudÃková-Girard, B; Scott, MC; Weinshilboum, R
Histamine N-methyltransferase: inhibition by monoamine oxidase inhibitors.
Agents Actions
40
1-10
1993
Homo sapiens
Barth, H; Lorenz, W; Troidl, H
Effect of amodiaquine on gastric histamine methyltransferase and on histamine-stimulated gastric secretion.
Br J Pharmacol
55
321-7
1975
Homo sapiens, Canis lupus familiaris, Sus scrofa
Cumming, P; Vincent, SR
Inhibition of histamine-N-methyltransferase (HNMT) by fragments of 9-amino-1,2,3,4-tetrahydroacridine (tacrine) and by beta-carbolines.
Biochem Pharmacol
44
989-92
1992
Rattus
Nishibori, M; Oishi, R; Itoh, Y; Saeki, K
9-Amino-1,2,3,4-tetrahydroacridine is a potent inhibitor of histamine N-methyltransferase.
Jpn J Pharmacol
55
539-46
1991
Bos taurus, Mus musculus
Futo, J; Kupferberg, JP; Moss, J
Inhibition of histamine N-methyltransferase (HNMT) in vitro by neuromuscular relaxants.
Biochem Pharmacol
39
415-20
1990
Homo sapiens
Futo, J; Kupferberg, JP; Moss, J; Fahey, MR; Cannon, JE; Miller, RD
Vecuronium inhibits histamine N-methyltransferase.
Anesthesiology
69
92-6
1988
Homo sapiens
Verburg, KM; Bowsher, RR; Henry, DP
A new radioenzymatic assay for histamine using purified histamine N-methyltransferase.
Life Sci
32
2855-67
1983
Homo sapiens
Klein, MC; Gertner, SB
Evidence for a role of endogenous histamine in central cardiovascular regulation: inhibition of histamine-N-methyltransferase by SKF 91488.
J Pharmacol Exp Ther
216
315-20
1981
Rattus, Metazoa
Asano, Y; Woodard, RW; Houck, DR; Floss, HG
Stereochemical course of the transmethylation catalyzed by histamine N-methyltransferase.
Arch Biochem Biophys
231
253-6
1984
Cavia porcellus
Price, RA; Scott, MC; Weinshilboum, RM
Genetic segregation analysis of red blood cell (RBC) histamine N-methyltransferase (HNMT) activity.
Genet Epidemiol
10
123-31
1993
Homo sapiens
Takemura, M; Yamauchi, K; Yamatodani, A
Structural analysis of histamine N-methyltransferase gene.
Methods Find Exp Clin Pharmacol
17 Suppl C
1-4
1995
Homo sapiens, Rattus
Tamaoki, J; Araake, M; Chiyotani, A; Isono, K; Nagai, A
Airway hyperresponsiveness to histamine in mycoplasmal infection: role of histamine N-methyltransferase.
Eur J Pharmacol
347
257-60
1998
Metazoa, Mycoplasma pneumoniae
Yan, L; Galinsky, RE; Bernstein, JA; Liggett, SB; Weinshilboum, RM
Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma.
Pharmacogenetics
10
261-6
2000
Homo sapiens
Yan, L; Szumlanski, CL; Rice, SR; Sobell, JL; Lachman, HM; Weinshilboum, RM
Histamine N-methyltransferase functional polymorphism: lack of association with schizophrenia.
Am J Med Genet
96
404-6
2000
Homo sapiens
Apelt, J; Ligneau, X; Pertz, HH; Arrang, JM; Ganellin, CR; Schwartz, JC; Schunack, W; Stark, H
Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity.
J Med Chem
45
1128-41
2002
Homo sapiens, Cavia porcellus
Chen, GL; Xu, ZH; Wang, W; Wang, GP; Zhou, G; Wang, D; Zhou, HH
Analysis of the C314T and A595G mutations in histamine N-methyltransferase gene in a Chinese population.
Clin Chim Acta
326
163-7
2002
Homo sapiens
Jochem, J
Endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats--studies with histamine N-methyltransferase inhibitor SKF 91488.
Inflamm Res
51
551-6
2002
Rattus, Rattus norvegicus, Metazoa
Chen, GL; Wang, W; Xu, ZH; Zhu, B; Wang, LS; Zhou, G; Wang, D; Zhou, HH
Genotype-phenotype correlation for histamine N-methyltransferase in a Chinese Han population.
Clin Chim Acta
334
179-83
2003
Homo sapiens
Grassmann, S; Apelt, J; Ligneau, X; Pertz, HH; Arrang, JM; Ganellin, CR; Schwartz, JC; Schunack, W; Stark, H
Search for histamine H(3) receptor ligands with combined inhibitory potency at histamine N-methyltransferase: omega-piperidinoalkanamine derivatives.
Arch Pharm (Weinheim)
337
533-45
2004
Homo sapiens, Rattus
Garcia-Martin, E; Mendoza, JL; Martinez, C; Taxonera, C; Urcelay, E; Ladero, JM; de la Concha, EG; Diaz-Rubio, M; Agundez, JA
Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene.
World J Gastroenterol
12
615-20
2006
Homo sapiens
Cao, H; Mei, Q; Zhang, L; Xu, J
C314T polymorphism in histamine N-methyltransferase gene and susceptibility to duodenal ulcer in Chinese population.
Clin Chim Acta
389
51-4
2008
Homo sapiens, Helicobacter pylori
Marasovi?-Šušnjara, I; Palada, V; Marinovi?-Terzi?, I; Mimica, N; Marin, J; Muck-Seler, D; Mustapi?, M; Prese?ki, P; Pivac, N; Folnegovi?-Šmalc, V; Marinovi?-?urin, J; Terzi?, J
No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.
Neurosci Lett
489
119-21
2011
Homo sapiens
Yang, X; Liu, C; Zhang, J; Han, H; Wang, X; Liu, Z; Xu, Y
Association of Histamine N-Methyltransferase Thr105Ile Polymorphism with Parkinson's Disease and Schizophrenia in Han Chinese: A Case-Control Study.
PLoS One
10
e0119692
0
Homo sapiens
Heidari, A; Tongsook, C; Najafipour, R; Musante, L; Vasli, N; Garshasbi, M; Hu, H; Mittal, K; McNaughton, AJ; Sritharan, K; Hudson, M; Stehr, H; Talebi, S; Moradi, M; Darvish, H; Arshad Rafiq, M; Mozhdehipanah, H; Rashidinejad, A; Samiei, S; Ghadami, M; Windpassinger, C; Gillessen-Kaesbach, G; Tzschach, A; Ahmed, I; Mikhailov, A; Stavropoulos, DJ; Carter, MT; Keshavarz, S; Ayub, M; Najmabadi, H; Liu, X; Ropers, HH; Macheroux, P; Vincent, JB
Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability.
Hum Mol Genet
24
5697-710
2015
Homo sapiens
Kitanaka, J; Kitanaka, N; Hall, FS; Uhl, GR; Takemura, M
Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose.
Drug Target Insights
10
1-7
2016
Mammalia
He, GH; Cai, WK; Zhang, JB; Ma, CY; Yan, F; Lu, J; Xu, GL
Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure.
Biomed Res Int
2016
1208476
2016
Homo sapiens
Jiménez-Jiménez, FJ; Alonso-Navarro, H; García-Martín, E; Agúndez, JA
Thr105Ile (rs11558538) polymorphism in the histamine N-methyltransferase (HNMT) gene and risk for Parkinson disease: A PRISMA-compliant systematic review and meta-analysis.
Medicine (Baltimore)
95
e4147
2016
Homo sapiens
Chen, Y; Cao, B; Ou, R; Wei, Q; Chen, X; Zhao, B; Wu, Y; Song, W; Shang, HF
Determining the Effect of the HNMT, STK39, and NMD3 Polymorphisms on the Incidence of Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Multiple System Atrophy in Chinese Populations.
J Mol Neurosci
2018
Homo sapiens
Yoshikawa, T; Nakamura, T; Yanai, K
Histamine N-Methyltransferase in the Brain.
Int J Mol Sci
20
2019
Homo sapiens, Mus sp.
Verhoeven, WMA; Egger, JIM; Janssen, PKC; van Haeringen, A
Adult male patient with severe intellectual disability caused by a homozygous mutation in the HNMT gene.
BMJ Case Rep
13
2020
Mus sp.
Weinshilboum, RM
Methylation pharmacogenetics: thiopurine methyltransferase as a model system.
Xenobiotica
22
1055-71
0
Homo sapiens
Deindl, P; Peri-Jerkan, S; Deichmann, K; Niggemann, B; Lau, S; Sommerfeld, C; Sengler, C; Müller, S; Wahn, U; Nickel, R; Heinzmann, A; ,
No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations.
Pediatr Allergy Immunol
16
40-2
2005
Homo sapiens
Ben-Hamida, A; Adesanya, AA; Man, WK; Spencer, J
Histamine and tissue fibrinolytic activity in duodenal ulcer disease.
Dig Dis Sci
43
126-32
1998
Homo sapiens
Garbarg, M; Barbin, G; Rodergas, E; Schwartz, JC
Inhibition of histamine synthesis in brain by alpha-fluoromethylhistidine, a new irreversible inhibitor: in vitro and in vivo studies.
J Neurochem
35
1045-52
1980
Mus musculus, Dialysis
Rafałowska, U; Waśkiewicz, J; Albrecht, J
Is neurotransmitter histamine predominantly inactivated in astrocytes?
Neurosci Lett
80
106-10
1987
Rattus
Nowak, JZ; Soćko, R
Histamine levels and activities of histamine metabolizing enzymes in mammalian ocular tissues: comparison between day and night.
Pol J Pharmacol Pharm
40
25-31
0
Oryctolagus cuniculus, Homo sapiens, Bos taurus
Lorenz, W; Thon, K; Barth, H; Neugebauer, E; Reimann, HJ; Kusche, J
Metabolism and function of gastric histamine in health and disease.
J Clin Gastroenterol
5 Suppl 1
37-56
1983
Homo sapiens, Indicator, animal
Kang, M; Yoshimatsu, H; Chiba, S; Kurokawa, M; Ogawa, R; Tamari, Y; Tatsukawa, M; Sakata, T
Hypothalamic neuronal histamine modulates physiological responses induced by interleukin-1 beta.
Am J Physiol
269
R1308-13
1995
Rattus
von Mach-Szczypiński, J; Stanosz, S; Sieja, K; Stanosz, M
Metabolism of histamine in tissues of primary ductal breast cancer.
Metabolism
2009
Homo sapiens
van Wamelen, DJ; Shan, L; Aziz, NA; Anink, JJ; Bao, AM; Roos, RA; Swaab, DF
Functional Increase of Brain Histaminergic Signaling in Huntington's Disease.
Brain Pathol
2010
Homo sapiens
Shan, L; Bossers, K; Unmehopa, U; Bao, AM; Swaab, DF
Alterations in the histaminergic system in Alzheimer's disease: a postmortem study.
Neurobiol Aging
2012
Homo sapiens
Stegaev, V; Nies, AT; Porola, P; Mieliauskaite, D; Sánchez-Jiménez, F; Urdiales, JL; Sillat, T; Schwelberger, HG; Chazot, PL; Katebe, M; Mackiewicz, Z; Konttinen, YT; Nordström, DC
Histamine transport and metabolism are deranged in salivary glands in Sjogren's syndrome.
Rheumatology (Oxford)
52
1599-608
2013
Homo sapiens
Umezu, K; Yuasa, S; Sudoh, A
Change of hepatic histamine content during hepatic fibrosis.
Biochem Pharmacol
34
2007-11
1985
Rattus
Morisset, S; Traiffort, E; Schwartz, JC
Inhibition of histamine versus acetylcholine metabolism as a mechanism of tacrine activity.
Eur J Pharmacol
315
R1-2
1996
Mus sp.
Schatz, RA; Wilens, TE; Sellinger, OZ
Decreased transmethylation of biogenic amines after in vivo elevation of brain S-adenosyl-l-homocysteine.
J Neurochem
36
1739-48
1981
Mus sp.
Alonso-Navarro, H; Jimenez-Jimenez, FJ; Garcia-Martin, E; Agundez, JA
Genomic and pharmacogenomic biomarkers of Parkinson's disease.
Curr Drug Metab
15
129-81
2014
Felis catus
Schlenk, F; Dainko, JL
The S-n-propyl analogue of S-adenosylmethionine.
Biochim Biophys Acta
385
312-23
1975
Saccharomyces cerevisiae
Ahmed, AE; Hanna, PE; Grund, VR
Conformationally restricted analogs of histamine H1 receptor antagonists: trans and cis-1-benzyl-3-dimethylamino-6-phenylpiperidine.
J Med Chem
19
117-22
1976
Cavia porcellus
Barth, H; Lorenz, W
[Histamine and its role in peptic gastric diseases: the discovery of histamine-H2-receptor antagonists]
Acta Med Austriaca
5
25-31
1978
Homo sapiens
Beaven, MA; Shaff, RE
Inhibition of histamine methylation in vivo by the dimaprit analog, SKF Compound 91488.
Agents Actions
9
455-60
1979
Mus sp.
Schayer, RW; Reilly, MA
Comparison of in vitro and in vivo histamine methylation by tissues.
Agents Actions
5
119-24
1975
Mus sp., Rattus, Cavia, Mus musculus, Cavia porcellus, Dialysis
Pacifici, GM; Donatelli, P; Giuliani, L
Histamine N-methyl transferase: inhibition by drugs.
Br J Clin Pharmacol
34
322-7
1992
Homo sapiens
Henry, DP; Bowsher, RR; Verburg, KM
Radioenzymatic assay for histamine: development and validation.
Scand J Gastroenterol Suppl
180
26-31
1991
Homo sapiens
Wollin, A
Uptake and methylation of histamine by dispersed gastric mucosal cells and its possible influence on acid secretion.
Can J Physiol Pharmacol
68
71-8
1990
Oryctolagus cuniculus
Fogel, WA; Swiderska, M; Maslinski, C
Histamine catabolism in proliferating skin.
Agents Actions
27
224-6
1989
Cavia porcellus
Timoney, AG; Man, WK; Spencer, J; Taylor, H; Williams, G
Histamine and duodenal ulceration in renal transplant recipients.
Gut
30
65-71
1989
Homo sapiens
Tachibana, T; Taniguchi, S; Furukawa, F; Imamura, S
Histamine metabolism in the Arthus reaction.
Exp Mol Pathol
44
76-82
1986
Cavia porcellus, Croton
Taniguchi, S; Tachibana, T; Miwa, S; Fujiwara, M; Imamura, S
Biogenic amines in the Arthus reaction.
Exp Mol Pathol
47
185-92
1987
Croton
Tuomisto, L; Tacke, U
Is histamine an anticonvulsive inhibitory transmitter?
Neuropharmacology
25
955-8
1986
Rattus, Metazoa
Verburg, KM; Bowsher, RR; Henry, DP
Quantification of urinary histamine by a new radioenzymatic assay: documentation of assay specificity and establishment of normal excretion rates.
J Allergy Clin Immunol
82
339-47
1988
Homo sapiens
Correa, FM; Saavedra, JM
Femtomole isotopic-enzymatic microassay of histamine in microgram amounts of brain tissue.
Braz J Med Biol Res
18
409-14
1985
Rattus
Hough, LB; Khandelwal, JK; Green, JP
Inhibition of brain histamine metabolism by metoprine.
Biochem Pharmacol
35
307-10
1986
Rattus
Haimart, M; Launay, JM; Zürcher, G; Cauet, N; Dreux, C; Da Prada, M
Simultaneous determination of histamine and N alpha-methylhistamine in biological samples by an improved enzymatic single isotope assay.
Agents Actions
16
71-5
1985
Homo sapiens
Yamatodani, A; Fukuda, H; Wada, H; Iwaeda, T; Watanabe, T
High-performance liquid chromatographic determination of plasma and brain histamine without previous purification of biological samples: cation-exchange chromatography coupled with post-column derivatization fluorometry.
J Chromatogr
344
115-23
1985
Mus musculus
Gatti, PJ; Gertner, SB
The effect of intrahypothalamic injection of homodimaprit on blood pressure.
Neuropharmacology
23
663-70
1984
Rattus, Metazoa
Schatz, RA; Wilens, TE; Tatter, SB; Gregor, P; Sellinger, OZ
Possible role of increased brain methylation in methionine sulfoximine epileptogenesis: effects of administration of adenosine and homocysteine thiolactone.
J Neurosci Res
10
437-47
1983
Metazoa
Mazurkiewicz-Kwilecki, IM; Prell, GD
Age-related changes in brain histamine.
Agents Actions
14
554-7
1984
Rattus, Metazoa
Almeida, AP; Beaven, MA
Phylogeny of histamine in vertebrate brain.
Brain Res
208
244-50
1981
vertebrata, Chondrichthyes, Squalus acanthias, amphibia
Tedford, CE; Yates, SL; Pawlowski, GP; Nalwalk, JW; Hough, LB; Khan, MA; Phillips, JG; Durant, GJ; Frederickson, RC
Pharmacological characterization of GT-2016, a non-thiourea-containing histamine H3 receptor antagonist: in vitro and in vivo studies.
J Pharmacol Exp Ther
275
598-604
1995
Rattus
Krause, M; Rouleau, A; Stark, H; Luger, P; Lipp, R; Garbarg, M; Schwart, JC; Schunack, W
Synthesis, X-ray crystallography, and pharmacokinetics of novel azomethine prodrugs of (R)-alpha-methylhistamine: highly potent and selective histamine H3 receptor agonists.
J Med Chem
38
4070-9
1995
Homo sapiens
Li, BY; Nalwalk, JW; Barker, LA; Cumming, P; Parsons, ME; Hough, LB
Characterization of the antinociceptive properties of cimetidine and a structural analog.
J Pharmacol Exp Ther
276
500-8
1996
Rattus
Tamaoki, J; Nakata, J; Takeyama, K; Chiyotani, A; Konno, K
Histamine H2 receptor-mediated airway goblet cell secretion and its modulation by histamine-degrading enzymes.
J Allergy Clin Immunol
99
233-8
1997
Cavia porcellus, Trachea
Rouleau, A; Garbarg, M; Ligneau, X; Mantion, C; Lavie, P; Advenier, C; Lecomte, JM; Krause, M; Stark, H; Schunack, W; Schwartz, JC
Bioavailability, antinociceptive and antiinflammatory properties of BP 2-94, a histamine H3 receptor agonist prodrug.
J Pharmacol Exp Ther
281
1085-94
1997
Homo sapiens, Rodentia
Inoue, H; Hisamatsu, KI; Yamauchi, M; Kumagai, N
Rapid and simple determination of histamine-N-methyl transferase activity by high-performance liquid chromatography with UV detection.
Mediators Inflamm
10
273-7
2001
Rattus
Yang, XY; Chen, L; Chen, H; Xu, ZP; Li, BL
Expression Purification and Activity ofhuman Myristoyl-CoA:N-myristoyltransferase.
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai)
31
175-179
1999
plasmids
Klaus, A; Weiss, H; Nguyen, JH; Margreiter, R; Obrist, P; Schwelberger, HG
Histamine-degrading enzymes as cellular markers of acute small bowel allograft rejection.
Transpl Int
16
474-9
2003
Rattus, Shewanella massilia
Cleary, JD; Schwartz, M; Rogers, PD; de Mestral, J; Chapman, SW
Effects of amphotericin B and caspofungin on histamine expression.
Pharmacotherapy
23
966-73
2003
Homo sapiens
Ishiura, Y; Fujimura, M; Nobata, K; Oribe, Y; Abo, M; Myou, S; Nonomura, A
In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamine.
Prostaglandins Other Lipid Mediat
75
1-12
2005
Metazoa
Ogasawara, M; Yamauchi, K; Satoh, Y; Yamaji, R; Inui, K; Jonker, JW; Schinkel, AH; Maeyama, K
Recent advances in molecular pharmacology of the histamine systems: organic cation transporters as a histamine transporter and histamine metabolism.
J Pharmacol Sci
101
24-30
2006
Rattus, Bronchus, Mus sp.
Maintz, L; Novak, N
Histamine and histamine intolerance.
Am J Clin Nutr
85
1185-96
2007
Homo sapiens
GarcÃa-MartÃn, E; GarcÃa-Menaya, J; Sánchez, B; MartÃnez, C; Rosendo, R; Agúndez, JA
Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis.
Clin Exp Allergy
37
1175-82
2007
Homo sapiens
GarcÃa-MartÃn, E; MartÃnez, C; Serrador, M; Alonso-Navarro, H; Navacerrada, F; Agúndez, JA; Jiménez-Jiménez, FJ
Histamine-N-methyl transferase polymorphism and risk for migraine.
Headache
48
1343-8
2008
Homo sapiens
Kuefner, MA; Feurle, J; Uder, M; Bautz, W; Schwelberger, HG
Influence of magnetic resonance contrast media on the activity of histamine inactivating enzymes.
Acad Radiol
16
358-62
2009
Homo sapiens
GarcÃa-MartÃn, E; MartÃnez, C; Benito-León, J; Calleja, P; DÃaz-Sánchez, M; Pisa, D; Alonso-Navarro, H; Ayuso-Peralta, L; Torrecilla, D; Agúndez, JA; Jiménez-Jiménez, FJ
Histamine-N-methyl transferase polymorphism and risk for multiple sclerosis.
Eur J Neurol
2009
Homo sapiens
Stevenson, J; Sonuga-Barke, E; McCann, D; Grimshaw, K; Parker, KM; Rose-Zerilli, MJ; Holloway, JW; Warner, JO
The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children's ADHD symptoms.
Am J Psychiatry
167
1108-15
2010
Homo sapiens
Szczepankiewicz, A; Breborowicz, A; Sobkowiak, P; Popiel, A
Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study.
Clin Mol Allergy
8
14
2010
Homo sapiens
Bonini, JS; Da Silva, WC; Da Silveira, CK; Köhler, CA; Izquierdo, I; Cammarota, M
Histamine facilitates consolidation of fear extinction.
Int J Neuropsychopharmacol
1-9
2011
Rattus norvegicus
Maldonado, M; Maeyama, K
Simultaneous electrochemical measurement method of histamine and N(?)-methylhistamine by high-performance liquid chromatography-amperometry with o-phthalaldehyde-sodium sulfite derivatization.
Anal Biochem
432
1-7
2013
Rattus norvegicus
Jiménez-Jiménez, FJ; García-Martín, E; Alonso-Navarro, H; Martínez, C; Zurdo, M; Turpín-Fenoll, L; Millán-Pascual, J; Adeva-Bartolomé, T; Cubo, E; Navacerrada, F; Rojo-Sebastián, A; Rubio, L; Ortega-Cubero, S; Pastor, P; Calleja, M; Plaza-Nieto, JF; Pilo-de-la-Fuente, B; Arroyo-Solera, M; García-Albea, E; Agúndez, JA
Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome.
J Neural Transm (Vienna)
124
285-291
2017
Homo sapiens
Yoshikawa, T; Nakamura, T; Yanai, K
[Analysis of brain histamine clearance using genetically engineered mice].
Nihon Yakurigaku Zasshi
152
16-20
0
Mus sp.
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