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IUBMB CommentsThis enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate.
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
trna 5-methylaminomethyl-2-thiouridylate methyltransferase, 5-methylaminomethyl-2-thiouridylate methyltransferase, 5-methylaminomethyl-2-thiouridylate-methyltransferase,
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5-methylaminomethyl-2-thiouridylate-methyltransferase
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methyltransferase, transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-
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S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
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transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase
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tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
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tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase
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tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
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methyl group transfer
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S-adenosyl-L-methionine:tRNA 5-(aminomethyl)-2-thiouridylate N-methyltransferase
This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate.
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S-adenosyl-L-methionine + 5-aminomethyl-2-thiouridine in tRNA
S-adenosyl-L-homocysteine + 5-methylaminomethyl-2-thiouridylate in tRNA
S-adenosyl-L-methionine + 5-aminomethyl-2-thiouridine in tRNA
S-adenosyl-L-homocysteine + 5-methylaminomethyl-2-thiouridylate in tRNA
enzyme plays a role in tRNA modification and protein synthesis, pivotal in the fidelity of the translational process
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S-adenosyl-L-methionine + 5-aminomethyl-2-thiouridine in tRNA
S-adenosyl-L-homocysteine + 5-methylaminomethyl-2-thiouridylate in tRNA
nucleotide modification at the wobble position 34 of anticodons
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S-adenosyl-L-methionine + 5-aminomethyl-2-thiouridine in tRNA
S-adenosyl-L-homocysteine + 5-methylaminomethyl-2-thiouridylate in tRNA
enzyme plays a role in tRNA modification and protein synthesis, pivotal in the fidelity of the translational process
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8.7
amino acid sequence calculation
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gene trmU
SwissProt
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additional information
the trmU gene is expressed in various tissues, but abundantly in tissues with high metabolic rates
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additional information
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the trmU gene is expressed in various tissues, but abundantly in tissues with high metabolic rates
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malfunction
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cell death and apoptosis are significantly increased after neomycin injury in cells with downregulated enzyme expression
physiological function
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the enzyme regulates mitochondrial function and reactive oxygen species levels
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MTU1_MOUSE
417
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47240
Swiss-Prot
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47240
x * 47240, amino acid sequence calculation
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x * 47240, amino acid sequence calculation
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gene trmU, DNA and amino acid sequence determination and analysis, expression in NIH3T3 cells mitochondria as N-terminal GFP-fusion protein
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enzyme expression is significantly decreased after 24 h neomycin treatment
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medicine
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the enzyme is a target for the prevention of aminoglycoside-induced hair cell death
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Yan, Q.; Guan, M.X.
Identification and characterization of mouse TRMU gene encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase
Biochim. Biophys. Acta
1676
119-126
2004
Mus musculus (Q9DAT5), Mus musculus
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He, Z.; Sun, S.; Waqas, M.; Zhang, X.; Qian, F.; Cheng, C.; Zhang, M.; Zhang, S.; Wang, Y.; Tang, M.; Li, H.; Chai, R.
Reduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitro
Sci. Rep.
6
29621
2016
Mus musculus
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