Reference on EC 2.1.1.5 - betaine-homocysteine S-methyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wang, J.; Dudman, N.P.; Lynch, J.; Wilcken, D.E.L.
Betaine:homocysteine methyltransferase - a new assay for the liver enzyme and its absence from human skin fibroblasts and peripheral blood lymphocytes
Clin. Chim. Acta
204
239-249
1991
Gallus gallus, Ovis aries, Homo sapiens
Skiba, W.E.; Wells, M.S.; Mangum, J.H.; Awad, W.M.
Betaine-homocysteine S-methyltransferase (human)
Methods Enzymol.
143
384-388
1987
Equus caballus, Homo sapiens
Finkelstein, J.D.; Harris, B.J.; Kyle, W.E.
Methionine metabolism in mammals: kinetic study of betaine-homocysteine methyltransferase
Arch. Biochem. Biophys.
153
320-324
1972
BRENDA: Rattus norvegicus
Textmining: Mammalia
Skiba, W.E.; Taylor, M.P.; Wells, M.S.; Mangum, J.H.; Awad, W.M.
Human hepatic methionine biosynthesis. Purification and characterization of betaine:homocysteine S-methyltransferase
J. Biol. Chem.
257
14944-14948
1982
Homo sapiens
Lee, K.H.; Cava, M.; Amiri, P.; Ottoboni, T.; Lindquist, R.N.
Betaine:homocysteine methyltransferase from rat liver: purification and inhibition by a boronic acid substrate analog
Arch. Biochem. Biophys.
292
77-86
1992
BRENDA: Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Textmining: Rattus
Finkelstein, J.D.; Martin, J.J.
Inactivation of betaine-homocysteine methyltransferase by adenosylmethionine and adenosylethionine
Biochem. Biophys. Res. Commun.
118
14-19
1984
BRENDA: Rattus norvegicus
Textmining: Rattus
Awad, W.M.; Whitney, P.L.; Skiba, W.E.; Mangum, J.H.; Wells, M.S.
Evidence for direct methyl transfer in betaine: homocysteine S-methyl-transferase
J. Biol. Chem.
258
12790-12792
1983
Homo sapiens
Finkelstein, J.D.; Kyle, W.E.; Harris, B.J.
Methionine metabolism in mammals: regulatory effects of S-adenosylhomocysteine
Arch. Biochem. Biophys.
165
774-779
1974
Rattus norvegicus
Gonzalez, B.; Pajares, M.A.; Too, H.P.; Garrido, F.; Blundell, T.L.; Sanz-Aparicio, J.
Crystallization and preliminary x-ray study of recombinant betaine-homocysteine S-methyltransferase from rat liver
Acta Crystallogr. Sect. D
58
1507-1510
2002
BRENDA: Rattus norvegicus
Textmining: Rattus
Bose, N.; Momany, C.
Crystallization and preliminary x-ray crystallographic studies of recombinant human betaine-homocysteine S-methyltransferase
Acta Crystallogr. Sect. D
57
431-433
2001
Homo sapiens
Millian, N.S.; Garrow, T.A.
Human betaine-homocysteine methyltransferase is a zinc metalloenzyme
Arch. Biochem. Biophys.
356
93-98
1998
BRENDA: Homo sapiens
Textmining: Escherichia coli, Dialysis
Emmert, J.L.; Garrow, T.A.; Baker, D.H.
Hepatic betaine-homocysteine methyltransferase activity in the chicken is influenced by dietary intake of sulfur amino acids, choline and betaine
J. Nutr.
126
2050-2058
1996
Gallus gallus
Garrow, T.A.
Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase
J. Biol. Chem.
271
22831-22838
1996
BRENDA: Homo sapiens (Q93088), Homo sapiens, Sus scrofa (Q95332), Sus scrofa
Textmining: Escherichia coli
Rao, P.V.; Garrow, T.A.; John, F.; Garland, D.; Millian, N.S.; Zigler, J.S., Jr.
Betaine-homocysteine methyltransferase is a developmentally regulated enzyme crystallin in rhesus monkey lens
J. Biol. Chem.
273
30669-30674
1998
BRENDA: Macaca mulatta
Textmining: Primates, Platyrrhini
Breksa, A.P.; Garrow, T.A.
Recombinant human liver betaine-homocysteine S-methyltransferase: Identification of three cysteine residues critical for zinc binding
Biochemistry
38
13991-13998
1999
BRENDA: Homo sapiens
Textmining: Escherichia coli, Astragalus bisulcatus
Incharoensakdi, A.; Waditee, R.
Degradation of glycinebetaine by betaine-homocysteine methyltransferase in Aphanothece halophytica: effect of salt downshock and starvation
Curr. Microbiol.
41
227-231
2000
Aphanothece halophytica
Waditee, R.; Incharoensakdi, A.
Purification and kinetic properties of betaine-homocysteine methyltransferase from Aphanothece halophytica
Curr. Microbiol.
43
107-111
2001
Aphanothece halophytica
Bose, N.; Greenspan, P.; Momany, C.
Expression of recombinant human betaine:homocysteine S-methyltransferase for x-ray crystallographic studies and further characterization of interaction with S-adenosylmethionine
Protein Expr. Purif.
25
73-80
2002
BRENDA: Homo sapiens
Textmining: Escherichia coli
Delgado-Reyes, C.V.; Wallig, M.A.; Garrow, T.A.
Immunohistochemical detection of betaine-homocysteine S-methyltransferase in human, pig, and rat liver and kidney
Arch. Biochem. Biophys.
393
184-186
2001
BRENDA: Homo sapiens, Rattus norvegicus, Sus scrofa
Textmining: Rattus, Primates, Metazoa
Breksa, A.P.; Garrow, T.A.
Random mutagenesis of the zinc-binding motif of betaine-homocysteine methyltransferase reveals that Gly214 Is essential
Arch. Biochem. Biophys.
399
73-80
2002
BRENDA: Homo sapiens
Textmining: Escherichia coli, Paradevosia shaoguanensis
Lambert, B.D.; Titgemeyer, E.C.; Stokka, G.L.; DeBey, B.M.; Loest, C.A.
Methionine supply to growing steers affects hepatic activities of methionine synthase and betaine-homocysteine methyltransferase, but not cystathionine synthase
J. Nutr.
132
2004-2009
2002
Glycine max, Triticum aestivum, Bos taurus
Delgado-Reyes, C.V.; Garrow, T.A.
High sodium chloride intake decreases betaine-homocysteine S-methyltransferase expression in guinea pig liver and kidney
Am. J. Physiol.
288
R182-187
2005
BRENDA: Sus scrofa
Textmining: Cavia porcellus, Cavia, Metazoa
Szegedi, S.S.; Garrow, T.A.
Oligomerization is required for betaine-homocysteine S-methyltransferase function
Arch. Biochem. Biophys.
426
32-42
2004
BRENDA: Homo sapiens (Q93088)
Textmining: Escherichia coli
Gonzalez, B.; Campillo, N.; Garrido, F.; Gasset, M.; Sanz-Aparicio, J.; Pajares, M.A.
Active-site-mutagenesis study of rat liver betaine-homocysteine S-methyltransferase
Biochem. J.
370
945-952
2003
BRENDA: Rattus norvegicus (O09171)
Textmining: Homo sapiens, Rattus
Garrido, F.; Gasset, M.; Sanz-Aparicio, J.; Alfonso, C.; Pajares, M.A.
Rat liver betaine homocysteine S-methyltransferase equilibrium unfolding: insights into intermediate structure through tryptophan substitutions
Biochem. J.
391
589-599
2005
BRENDA: Rattus norvegicus
Textmining: Rattus
Miller, C.M.; Szegedi, S.S.; Garrow, T.A.
Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro
Biochem. J.
392
443-448
2005
Homo sapiens (Q93088), Homo sapiens
Forestier, M.; Banninger, R.; Reichen, J.; Solioz, M.
Betaine homocysteine methyltransferase: gene cloning and expression analysis in rat liver cirrhosis
Biochim. Biophys. Acta
1638
29-34
2003
BRENDA: Rattus norvegicus
Textmining: Metazoa, Rattus
Collinsova, M.; Castro, C.; Garrow, T.A.; Yiotakis, A.; Dive, V.; Jiracek, J.
Combining combinatorial chemistry and affinity chromatography: highly selective inhibitors of human betaine: homocysteine S-methyltransferase
Chem. Biol.
10
113-122
2003
BRENDA: Homo sapiens
Textmining: Rattus
Ichikawa, A.; Ohashi, Y.; Terada, S.; Natsuka, S.; Ikura, K.
In vitro modification of betaine-homocysteine S-methyltransferase by tissue-type transglutaminase
Int. J. Biochem. Cell Biol.
36
1981-1992
2004
BRENDA: Sus scrofa
Textmining: Cavia porcellus
Gonzalez, B.; Pajares, M.A.; Martinez-Ripoll, M.; Blundell, T.L.; Sanz-Aparicio, J.
Crystal structure of rat liver betaine homocysteine S-methyltransferase reveals new oligomerization features and conformational changes upon substrate binding
J. Mol. Biol.
338
771-782
2004
BRENDA: Rattus norvegicus (O09171)
Textmining: Rattus, Homo sapiens
Ratnam, S.; Wijekoon, E.P.; Hall, B.; Garrow, T.A.; Brosnan, M.E.; Brosnan, J.T.
Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver
Am. J. Physiol. Endocrinol. Metab.
290
E933-E939
2006
BRENDA: Rattus norvegicus
Textmining: Rattus
Nieman, K.M.; Hartz, C.S.; Szegedi, S.S.; Garrow, T.A.; Sparks, J.D.; Schalinske, K.L.
Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats
Am. J. Physiol. Endocrinol. Metab.
291
E1235-E1242
2006
BRENDA: Rattus norvegicus
Textmining: Rattus
Schaefer, C.; Hoffmann, L.; Heldt, K.; Lornejad-Schaefer, M.R.; Brauers, G.; Gehrmann, T.; Garrow, T.A.; Haeussinger, D.; Mayatepek, E.; Schwahn, B.C.; Schliess, F.
Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells
Am. J. Physiol. Gastrointest. Liver Physiol.
292
G1089-G1098
2007
BRENDA: Mus musculus, Rattus norvegicus, Rattus norvegicus (O09171)
Textmining: Rattus, Homo sapiens
Sparks, J.D.; Collins, H.L.; Chirieac, D.V.; Cianci, J.; Jokinen, J.; Sowden, M.P.; Galloway, C.A.; Sparks, C.E.
Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase
Biochem. J.
395
363-371
2006
BRENDA: Rattus norvegicus
Textmining: Rattus
Ou, X.; Yang, H.; Ramani, K.; Ara, A.I.; Chen, H.; Mato, J.M.; Lu, S.C.
Inhibition of human betaine-homocysteine methyltransferase expression by S-adenosylmethionine and methylthioadenosine
Biochem. J.
401
87-96
2007
Homo sapiens (Q6EI07), Homo sapiens
Pajares, M.A.; Perez-Sala, D.
Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?
Cell. Mol. Life Sci.
63
2792-2803
2006
Cavia porcellus, Ovis aries, Homo sapiens, Macaca mulatta, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Sus scrofa, Mus musculus C57/BL6J
Kim, H.S.; Kim, J.M.; Roh, K.B.; Lee, H.H.; Kim, S.J.; Shin, Y.H.; Lee, B.L.
Rat liver 10-formyltetrahydrofolate dehydrogenase, carbamoyl phosphate synthetase 1 and betaine homocysteine S-methytransferase were co-purified on Kunitz-type soybean trypsin inhibitor-coupled sepharose CL-4B
J. Biochem. Mol. Biol.
40
604-609
2007
Rattus, Glycine max
Jiracek, J.; Collinsova, M.; Rosenberg, I.; Budesinsky, M.; Protivinska, E.; Netusilova, H.; Garrow, T.A.
S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase
J. Med. Chem.
49
3982-3989
2006
BRENDA: Homo sapiens
Textmining: Mus sp.
Collinsova, M.; Strakova, J.; Jiracek, J.; Garrow, T.A.
Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice
J. Nutr.
136
1493-1497
2006
BRENDA: Mus musculus
Textmining: Mus sp.
Slow, S.; Garrow, T.A.
Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats
J. Nutr.
136
2279-2283
2006
BRENDA: Rattus norvegicus
Textmining: Rattus
Pillai, P.B.; Fanatico, A.C.; Beers, K.W.; Blair, M.E.; Emmert, J.L.
Homocysteine remethylation in young broilers fed varying levels of methionine, choline, and betaine
Poult. Sci.
85
90-95
2006
Gallus gallus
Ji, C.; Shinohara, M.; Vance, D.; Than, T.A.; Ookhtens, M.; Chan, C.; Kaplowitz, N.
Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver
Alcohol. Clin. Exp. Res.
32
1049-1058
2008
BRENDA: Homo sapiens
Textmining: Mus sp.
Castro, C.; Millian, N.S.; Garrow, T.A.
Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc
Arch. Biochem. Biophys.
472
26-33
2008
BRENDA: Homo sapiens, Mus musculus
Textmining: Mus sp.
Ji, C.; Shinohara, M.; Kuhlenkamp, J.; Chan, C.; Kaplowitz, N.
Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes
Hepatology
46
1586-1596
2007
BRENDA: Homo sapiens (Q93088)
Textmining: Mus musculus
Szegedi, S.S.; Castro, C.C.; Koutmos, M.; Garrow, T.A.
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase
J. Biol. Chem.
283
8939-8945
2008
Homo sapiens, Mus musculus
Ananth, C.V.; Elsasser, D.A.; Kinzler, W.L.; Peltier, M.R.; Getahun, D.; Leclerc, D.; Rozen, R.R.; Rozen, R.R.
Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption
Mol. Genet. Metab.
91
104-110
2007
Homo sapiens
Li, F.; Feng, Q.; Lee, C.; Wang, S.; Pelleymounter, L.L.; Moon, I.; Eckloff, B.W.; Wieben, E.D.; Schaid, D.J.; Yee, V.; Weinshilboum, R.M.
Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization
Mol. Genet. Metab.
94
326-335
2008
BRENDA: Homo sapiens
Textmining: Oryctolagus cuniculus
Clow, K.A.; Treberg, J.R.; Brosnan, M.E.; Brosnan, J.T.
Elevated tissue betaine contents in developing rats are due to dietary betaine, not to synthesis
J. Nutr.
138
1641-1646
2008
Mammalia
Mercer, C.; Kaliappan, A.; Dennis, P.
Macroautophagy-dependent, intralysosomal cleavage of a betaine homocysteine methyltransferase fusion protein requires stable multimerization
Autophagy
4
185-194
2008
BRENDA: Homo sapiens
Textmining: Saccharomyces cerevisiae
Kharbanda, K.K.; Vigneswara, V.; McVicker, B.L.; Newlaczyl, A.U.; Bailey, K.; Tuma, D.; Ray, D.E.; Carter, W.G.
Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats
Biochem. Biophys. Res. Commun.
381
523-527
2009
BRENDA: Rattus norvegicus
Textmining: Rattus
Liu, H.H.; Lu, P.; Guo, Y.; Farrell, E.; Zhang, X.; Zheng, M.; Bosano, B.; Zhang, Z.; Allard, J.; Liao, G.; Fu, S.; Chen, J.; Dolim, K.; Kuroda, A.; Usuka, J.; Cheng, J.; Tao, W.; Welch, K.; Liu, Y.; Pease, J.; de Keczer, S.A.; Masjedizadeh, M.; Hu, J.S.; Weller, P.; Garrow, T.; Peltz, G.
An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity
Genome Res.
20
28-35
2010
BRENDA: Mus musculus
Textmining: Mus sp.
Xu, Y.Y.; Guan, D.Y.; Yang, M.; Wang, H.; Shen, Z.H.
All-trans-retinoic acid intensifies endoplasmic reticulum stress in N-acetylglucosaminyltransferase V repressed human hepatocarcinoma cells by perturbing homocysteine metabolism
J. Cell. Biochem.
109
468-477
2010
Homo sapiens
Vanek, V.; Budesinsky, M.; Kabeleova, P.; Sanda, M.; Kozisek, M.; Hanclova, I.; Mladkova, J.; Brynda, J.; Rosenberg, I.; Koutmos, M.; Garrow, T.A.; Jiracek, J.
Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase
J. Med. Chem.
52
3652-3665
2009
Homo sapiens
Ohuchi, S.; Morita, T.; Mori, M.; Sugiyama, K.
Hepatic cystathionine beta-synthase activity does not increase in response to methionine supplementation in rats fed a low casein diet: association with plasma homocysteine concentrations
J. Nutr. Sci. Vitaminol.
55
178-185
2009
BRENDA: Rattus norvegicus
Textmining: Rattus
Brosnan, J.T.; Wijekoon, E.P.; Warford-Woolgar, L.; Trottier, N.L.; Brosnan, M.E.; Brunton, J.A.; Bertolo, R.F.
Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance
J. Nutr.
139
1292-1297
2009
Sus scrofa
Korinek, M.; Sistek, V.; Mladkova, J.; Mikes, P.; Jiracek, J.; Selicharova, I.
Quantification of homocysteine-related metabolites and the role of betaine-homocysteine S-methyltransferase in HepG2 cells
Biomed. Chromatogr.
27
111-121
2013
Homo sapiens (Q93088)
Lee, M.B.; Kooistra, M.; Zhang, B.; Slow, S.; Fortier, A.L.; Garrow, T.A.; Lever, M.; Trasler, J.M.; Baltz, J.M.
Betaine homocysteine methyltransferase is active in the mouse blastocyst and promotes inner cell mass development
J. Biol. Chem.
287
33094-33103
2012
Mus musculus (O35490), Mus musculus
Fridman, O.; Morales, A.V.; Bortoni, L.E.; Turk-Noceto, P.C.; Prieto, E.A.
Corticoadrenal activity in rat regulates betaine-homocysteine S-methyltransferase expression with opposite effects in liver and kidney
J. Biosci.
37
115-123
2012
BRENDA: Rattus norvegicus
Textmining: Rattus, animal
Mladkova, J.; Vanek, V.; Budesinsky, M.; Elbert, T.; Demianova, Z.; Garrow, T.A.; Jiracek, J.
Double-headed sulfur-linked amino acids as first inhibitors for betaine-homocysteine S-methyltransferase 2
J. Med. Chem.
55
6822-6831
2012
BRENDA: Homo sapiens
Textmining: Mammalia
Selicharova, I.; Korinek, M.; Demianova, Z.; Chrudinova, M.; Mladkova, J.; Jiracek, J.
Effects of hyperhomocysteinemia and betaine-homocysteine S-methyltransferase inhibition on hepatocyte metabolites and the proteome
Biochim. Biophys. Acta
1834
1596-1606
2013
Homo sapiens (Q93088), Homo sapiens
Ma, H.; Ning, J.; Jin, X.; Mao, C.; Bu, X.; Wang, M.; Liu, H.; Wang, K.; Lausted, C.; Hood, L.; Chen, J.; Hu, Z.
Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury
Biomarkers
19
578-584
2014
Homo sapiens
Van den Bergh, K.; Vercammen, M.; Regenass, S.; Derua, R.; Vermeersch, P.; Pokreisz, P.; Ocmant, A.; de Beeck, K.; Janssens, S.; Waelkens, E.; Bossuyt, X.
Betaine homocysteine methyl transferase 1, a novel auto-antigen associated with anti-Golgi immune reactivity
Clin. Chim. Acta
413
105-108
2012
BRENDA: Homo sapiens
Textmining: Rattus
Picha, J.; Vanek, V.; Budesinsky, M.; Mladkova, J.; Garrow, T.A.; Jiracek, J.
The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase
Eur. J. Med. Chem.
65
256-275
2013
Homo sapiens (Q93088), Homo sapiens
Zhang, B.; Denomme, M.M.; White, C.R.; Leung, K.Y.; Lee, M.B.; Greene, N.D.; Mann, M.R.; Trasler, J.M.; Baltz, J.M.
Both the folate cycle and betaine-homocysteine methyltransferase contribute methyl groups for DNA methylation in mouse blastocysts
FASEB J.
29
1069-1079
2015
Mus musculus
Ganu, R.; Garrow, T.; Koutmos, M.; Rund, L.; Schook, L.B.
Splicing variants of the porcine betaine-homocysteine S-methyltransferase gene: implications for mammalian metabolism
Gene
529
228-237
2013
BRENDA: Sus scrofa
Textmining: Homo sapiens, Suidae, Rodentia
Zhang, Y.; Zhu, T.; Wang, L.; Pan, Y.; Zhang, S.
Homocysteine homeostasis and betaine-homocysteine S-methyltransferase expression in the brain of hibernating bats
PLoS ONE
8
e85632
2013
BRENDA: Myotis ricketti (A0A059PVS2)
Textmining: Chiroptera, Rattus, Mammalia
Mladkova, J.; Hladilkova, J.; Diamond, C.E.; Tryon, K.; Yamada, K.; Garrow, T.A.; Jungwirth, P.; Koutmos, M.; Jiracek, J.
Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase
Proteins
82
2552-2564
2014
Homo sapiens (Q93088), Homo sapiens
Ahn, C.W.; Jun, D.S.; Na, J.D.; Choi, Y.J.; Kim, Y.C.
Alleviation of hepatic fat accumulation by betaine involves reduction of homocysteine via up-regulation of betaine-homocysteine methyltransferase (BHMT)
Biochem. Biophys. Res. Commun.
477
440-447
2016
Rattus norvegicus
Wu, L.; Zhou, X.; Li, T.; He, J.; Huang, L.; Ouyang, Z.; He, L.; Wei, T.; He, Q.
Improved Sp1 and betaine homocysteine-S-methyltransferase expression and homocysteine clearance are involved in the effects of zinc on oxidative stress in high-fat-diet-pretreated mice
Biol. Trace Elem. Res.
184
436-441
2018
Mus musculus
Coleman, D.N.; Vailati-Riboni, M.; Elolimy, A.A.; Cardoso, F.C.; Rodriguez-Zas, S.L.; Miura, M.; Pan, Y.X.; Loor, J.J.
Hepatic betaine-homocysteine methyltransferase and methionine synthase activity and intermediates of the methionine cycle are altered by choline supply during negative energy balance in Holstein cows
J. Dairy Sci.
102
8305-8318
2019
Bos taurus
Zhou, Z.; Garrow, T.A.; Dong, X.; Luchini, D.N.; Loor, J.J.
Hepatic activity and transcription of betaine-homocysteine methyltransferase, methionine synthase, and cystathionine synthase in periparturient dairy cows are altered to different extents by supply of methionine and choline
J. Nutr.
147
11-19
2017
Bos taurus
Saande, C.J.; Pritchard, S.K.; Worrall, D.M.; Snavely, S.E.; Nass, C.A.; Neuman, J.C.; Luchtel, R.A.; Dobiszewski, S.; Miller, J.W.; Vailati-Riboni, M.; Loor, J.J.; Schalinske, K.L.
Dietary egg protein prevents hyperhomocysteinemia via upregulation of hepatic betaine-homocysteine S-methyltransferase activity in folate-restricted rats
J. Nutr.
149
1369-1376
2019
BRENDA: Rattus norvegicus
Textmining: Rattus
Garrido, F.; Pacheco, M.; Vargas-Martinez, R.; Velasco-Garcia, R.; Jorge, I.; Serrano, H.; Portillo, F.; Vazquez, J.; Pajares, M.A.
Identification of hepatic protein-protein interaction targets for betaine homocysteine S-methyltransferase
PLoS ONE
13
e0199472
2018
BRENDA: Rattus norvegicus (O09171), Rattus norvegicus
Textmining: Saccharomyces cerevisiae
Overbye, A; Stre, F; Hagen, LK; Johansen, HT; Seglen, PO
Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain.
Autophagy
7
1011-27
2011
Rattus
Doi, T; Kawata, T; Tadano, N; Iijima, T; Maekawa, A
Effect of vitamin B12-deficiency on the activity of hepatic cystathionine beta-synthase in rats.
J Nutr Sci Vitaminol (Tokyo)
35
101-10
1989
Rattus
Schwahn, BC; Wendel, U; Lussier-Cacan, S; Mar, MH; Zeisel, SH; Leclerc, D; Castro, C; Garrow, TA; Rozen, R
Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency.
Metabolism
53
594-9
2004
Mus sp., Mus musculus
Alberto, JM; Hamelet, J; Noll, C; Blaise, S; Bronowicki, JP; Guéant, JL; Delabar, JM; Janel, N
Mice deficient in cystathionine beta synthase display altered homocysteine remethylation pathway.
Mol Genet Metab
91
396-8
2007
Mus sp.
Maclean, KN; Jiang, H; Greiner, LS; Allen, RH; Stabler, SP
Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: Decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk.
Mol Genet Metab
105
395-403
2012
Mus musculus, Mus sp.
Huang, X; Li, D; Zhao, Q; Zhang, C; Ren, B; Yue, L; Du, B; Godfrey, O; Wang, X; Zhang, W
Association between BHMT and CBS gene promoter methylation with the efficacy of folic acid therapy in patients with hyperhomocysteinemia.
J Hum Genet
64
1227-1235
2019
Homo sapiens
Jiang, H; Hurt, KJ; Breen, K; Stabler, SP; Allen, RH; Orlicky, DJ; Maclean, KN
Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap.
Biol Open
4
1154-62
2015
Mus sp.
Ndisang, JF
The Heme Oxygenase System Selectively Modulates Proteins Implicated in Metabolism, Oxidative Stress and Inflammation in Spontaneously Hypertensive Rats.
Curr Pharm Des
2013
Metazoa
Balińska, M; Paszewski, A
Betaine-homocysteine methyltransferase in the fungus Aspergillus nidulans.
Biochem Biophys Res Commun
91
1095-100
1979
Aspergillus nidulans
McKeever, MP; Weir, DG; Molloy, A; Scott, JM
Betaine-homocysteine methyltransferase: organ distribution in man, pig and rat and subcellular distribution in the rat.
Clin Sci (Lond)
81
551-6
1991
Homo sapiens, Sus scrofa, Rattus
White, RF; Kaplan, L; Birnbaum, J
Betaine-homocysteine transmethylase in Pseudomonas denitrificans, a vitamin B 12 overproducer.
J Bacteriol
113
218-23
1973
Pseudomonas denitrificans (nom. rej.)
Grzelakowska-Sztabert, B; Balińska, M
Induction of betaine: homocysteine methyltransferase in some murine cells cultured in vitro.
Biochim Biophys Acta
632
164-72
1980
Mus musculus
Sunden, SL; Renduchintala, MS; Park, EI; Miklasz, SD; Garrow, TA
Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene.
Arch Biochem Biophys
345
171-4
1997
Homo sapiens, Sus scrofa
Emmert, JL; Webel, DM; Biehl, RR; Griffiths, MA; Garrow, LS; Garrow, TA; Baker, DH
Hepatic and renal betaine-homocysteine methyltransferase activity in pigs as affected by dietary intakes of sulfur amino acids, choline, and betaine.
J Anim Sci
76
606-10
1998
Rattus, Suidae
Park, EI; Garrow, TA
Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene.
J Biol Chem
274
7816-24
1999
Homo sapiens, Rattus
Neece, DJ; Griffiths, MA; Garrow, TA
Isolation and characterization of a mouse betaine-homocysteine S-methyltransferase gene and pseudogene.
Gene
250
31-40
2000
Mus musculus, Homo sapiens, Cricetulus griseus
Heil, SG; Lievers, KJ; Boers, GH; Verhoef, P; den Heijer, M; Trijbels, FJ; Blom, HJ
Betaine-homocysteine methyltransferase (BHMT): genomic sequencing and relevance to hyperhomocysteinemia and vascular disease in humans.
Mol Genet Metab
71
511-9
2000
Homo sapiens
Furuya, N; Kanazawa, T; Fujimura, S; Ueno, T; Kominami, E; Kadowaki, M
Leupeptin-induced appearance of partial fragment of betaine homocysteine methyltransferase during autophagic maturation in rat hepatocytes.
J Biochem (Tokyo)
129
313-20
2001
Rattus
Shibata, T; Akamine, T; Nikki, T; Yamashita, H; Nobukuni, K
Synthesis of betaine-homocysteine S-methyltransferase is continuously enhanced in fatty livers of thyroidectomized chickens.
Poult Sci
82
207-13
2003
Gallus gallus
ERICSON, LE; HARPER, AE
Effect of diet on betaine-homocysteine transmethylase of rat liver. III. B-vitamins other than vitamin B12.
Proc Soc Exp Biol Med
90
298-300
1955
Rattus
ERICSON, LE; HARPER, AE
Effect of diet on the betaine-homocysteine transmethylase activity of rat liver. I. Amino acids and protein.
J Biol Chem
219
49-58
1956
Rattus
ERICSON, LE; HARPER, AE; WILLIAMS, JN; ELVEHJEM, CA
Effect of diet on the betaine-homocysteine transmethylase activity of rat liver. II. Vitamin B12.
J Biol Chem
219
59-67
1956
Rattus
Shinohara, M; Ji, C; Kaplowitz, N
Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats.
Hepatology
51
796-805
2010
Mus sp., Rattus, Homo sapiens, Mus musculus
Feng, Q; Kalari, K; Fridley, BL; Jenkins, G; Ji, Y; Abo, R; Hebbring, S; Zhang, J; Nye, MD; Leeder, JS; Weinshilboum, RM
Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation.
Mol Genet Metab
102
126-33
2011
Homo sapiens
Ganu, RS; Garrow, TA; Sodhi, M; Rund, LA; Schook, LB
Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes.
Gene
473
133-8
2011
Sus scrofa, Homo sapiens, Suidae, animal, Rodentia
Peng, JP; Zhang, J; Huang, HW; Wang, FH; Du, XJ; Luo, PC
L-arginine-glycine amidinotransferase, betaine-homocysteine S-methyltransferase, and neuropolypeptide H3 are diminished in renal clear cell carcinoma of humans.
Saudi Med J
32
467-73
2011
Homo sapiens
Strakova, J; Gupta, S; Kruger, WD; Dilger, RN; Tryon, K; Li, L; Garrow, TA
Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine ?-synthase activity and methylation capacity.
Nutr Res
31
563-71
2011
Metazoa, Rattus
Chmurzynska, A; Malinowska, AM
Homocysteine homeostasis in the rat is maintained by compensatory changes in cystathionine ?-synthase, betaine-homocysteine methyltransferase, and phosphatidylethanolamine N-methyltransferase gene transcription occurring in response to maternal protein and folic acid intake during pregnancy and fat intake after weaning.
Nutr Res
31
572-8
2011
Rattus
Teng, YW; Mehedint, MG; Garrow, TA; Zeisel, SH
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas.
J Biol Chem
286
36258-67
2011
Mus sp., Homo sapiens, Mus musculus
Teng, YW; Ellis, JM; Coleman, RA; Zeisel, SH
Mouse betaine-homocysteine S-Methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue.
J Biol Chem
2012
Mus musculus, Mus sp.
Teng, YW; Cerdena, I; Zeisel, SH
Homocysteinemia in mice with genetic betaine homocysteine S-methyltransferase deficiency is independent of dietary folate intake.
J Nutr
142
1964-7
2012
Mus sp.
Pellanda, H
Betaine homocysteine methyltransferase (BHMT)-dependent remethylation pathway in human healthy and tumoral liver.
Clin Chem Lab Med
51
617-21
2013
Homo sapiens
Ong, JL; Woo, JM; Hiong, KC; Ching, B; Wong, WP; Chew, SF; Ip, YK
Molecular characterization of betaine-homocysteine methyltransferase 1 from the liver, and effects of aestivation on its expressions and homocysteine concentrations in the liver, kidney and muscle, of the African lungfish, Protopterus annectens.
Comp Biochem Physiol B Biochem Mol Biol
183C
30-41
2015
Protopterus aethiopicus, Protopterus annectens, Callorhinchus milii, Tetrapoda, animal
Jurkowska, H; Niewiadomski, J; Hirschberger, LL; Roman, HB; Mazor, KM; Liu, X; Locasale, JW; Park, E; Stipanuk, MH
Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo.
Amino Acids
48
665-76
2016
Mus sp., Mus musculus
Rosa, J; Tiago, DM; Marques, CL; Vijayakumar, P; Fonseca, L; Cancela, ML; Laiz, V
Central role of betaine-homocysteine S-methyltransferase 3 in chondral ossification and evidence for sub-functionalization in neoteleost fish.
Biochim Biophys Acta
2016
Chondrichthyes, Sparus aurata
Prieur, EAK; Pjetri, E; Zeisel, SH; Jadavji, NM
Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice.
Appl Physiol Nutr Metab
1-4
2017
Mus sp., Mus musculus
Maclean, KN; Jiang, H; Phinney, WN; Keating, AK; Hurt, KJ; Stabler, SP
Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine ?-synthase-deficient homocystinuria.
FASEB J
fj201802069RR
2019
Mus musculus
Tanghe, KA; Garrow, TA; Schalinske, KL
Triiodothyronine treatment attenuates the induction of hepatic glycine N-methyltransferase by retinoic acid and elevates plasma homocysteine concentrations in rats.
J Nutr
134
2913-8
2004
Rattus
Sternowsky, HJ; Räihä, NC; Gaull, G
Methionine adenosyltransferase and transmethylation in fetal and neonatal lung of the human, monkey, and rabbit.
Pediatr Res
10
545-50
1976
Homo sapiens
Lu, XJ; Chen, J; Huang, ZA; Shi, YH; Wang, F
Proteomic analysis on the alteration of protein expression in gills of ayu (Plecoglossus altivelis) associated with salinity change.
Comp Biochem Physiol Part D Genomics Proteomics
5
185-9
2010
Plecoglossus altivelis, Chondrichthyes
Steele, W; Allegrucci, C; Singh, R; Lucas, E; Priddle, H; Denning, C; Sinclair, K; Young, L
Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction?
Reprod Biomed Online
10
755-66
2005
Homo sapiens
Zhou, YF; Zhou, Z; Batistel, F; Martinez-Corts, I; Pate, RT; Luchini, DL; Loor, JJ
Methionine and choline supply alter transmethylation, transsulfuration, and cytidine 5'-diphosphocholine pathways to different extents in isolated primary liver cells from dairy cows.
J Dairy Sci
101
11384-11395
2018
Bos taurus
Xue, GP; Snoswell, AM
Developmental changes in the activities of enzymes related to methyl group metabolism in sheep tissues.
Comp Biochem Physiol B
83
115-20
1986
Ovis aries, Rattus
Finkelstein, JD; Martin, JJ
Methionine metabolism in mammals. Distribution of homocysteine between competing pathways.
J Biol Chem
259
9508-13
1984
Mammalia, Rattus
Okawa, H; Morita, T; Sugiyama, K
Cysteine supplementation decreases plasma homocysteine concentration in rats fed on a low-casein diet in rats.
Biosci Biotechnol Biochem
71
91-7
2007
Rattus
Williams, KT; Garrow, TA; Schalinske, KL
Type I diabetes leads to tissue-specific DNA hypomethylation in male rats.
J Nutr
138
2064-9
2008
Rattus
Ohuchi, S; Matsumoto, Y; Morita, T; Sugiyama, K
High-casein diet suppresses guanidinoacetic acid-induced hyperhomocysteinemia and potentiates the hypohomocysteinemic effect of serine in rats.
Biosci Biotechnol Biochem
72
3258-64
2008
Rattus
Setoue, M; Ohuchi, S; Morita, T; Sugiyama, K
Choline deprivation induces hyperhomocysteinemia in rats fed low methionine diets.
J Nutr Sci Vitaminol (Tokyo)
54
483-90
2008
Rattus
Ohuchi, S; Matsumoto, Y; Morita, T; Sugiyama, K
High casein diet decreases plasma homocysteine concentration in rats.
J Nutr Sci Vitaminol (Tokyo)
55
22-30
2009
Rattus, Rattus norvegicus
Kawakami, Y; Ohuchi, S; Morita, T; Sugiyama, K
Hypohomocysteinemic effect of cysteine is associated with increased plasma cysteine concentration in rats fed diets low in protein and methionine levels.
J Nutr Sci Vitaminol (Tokyo)
55
66-74
2009
Glycine max, Rattus
Benkhalifa, M; Montjean, D; Cohen-Bacrie, P; Ménézo, Y
Imprinting: RNA expression for homocysteine recycling in the human oocyte.
Fertil Steril
2009
Homo sapiens
Strakova, J; Williams, KT; Gupta, S; Schalinske, KL; Kruger, WD; Rozen, R; Jiracek, J; Li, L; Garrow, TA
Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats.
Nutr Res
30
492-500
2010
Rattus, Mus sp.
Yun, KU; Ryu, CS; Oh, JM; Kim, CH; Lee, KS; Lee, CH; Lee, HS; Kim, BH; Kim, SK
Plasma homocysteine level and hepatic sulfur amino acid metabolism in mice fed a high-fat diet.
Eur J Nutr
2012
Mus sp.
Liu, Y; Liu, YQ; Morita, T; Mori, M; Sugiyama, K
Effect of dietary supplementation with folate on choline deficiency-induced hyperhomocysteinemia in rats.
J Nutr Sci Vitaminol (Tokyo)
58
20-8
2012
Glycine max, Rattus
Dahlhoff, C; Desmarchelier, C; Sailer, M; Frst, RW; Haag, A; Ulbrich, SE; Hummel, B; Obeid, R; Geisel, J; Bader, BL; Daniel, H
Hepatic Methionine Homeostasis Is Conserved in C57BL/6N Mice on High-Fat Diet Despite Major Changes in Hepatic One-Carbon Metabolism.
PLoS One
8
e57387
2013
Mus sp.
Liu, YQ; Jia, Z; Han, F; Inakuma, T; Miyashita, T; Sugiyama, K; Sun, LC; Xiang, XS; Huang, ZW
Suppression effects of betaine-enriched spinach on hyperhomocysteinemia induced by guanidinoacetic acid and choline deficiency in rats.
ScientificWorldJournal
2014
904501
2014
Spinacia oleracea
Deminice, R; Padilha, Cde S; Borges, F; da Silva, LE; Rosa, FT; Robinson, JL; Cecchini, R; Guarnier, FA; Frajacomo, FT
Resistance exercise prevents impaired homocysteine metabolism and hepatic redox capacity in Walker-256 tumor-bearing male Wistar rats.
Nutrition
32
1153-8
2016
Rattus
Bries, AE; Webb, JL; Vogel, B; Carrillo, C; Keating, AF; Pritchard, SK; Roslan, G; Miller, JW; Schalinske, KL
Letrozole-Induced Polycystic Ovary Syndrome Attenuates Cystathionine-? Synthase mRNA and Protein Abundance in the Ovaries of Female Sprague Dawley Rats.
J Nutr
151
1407-1415
2021
Rattus
Marchand, J; Evrard, E; Guinand, B; Cachot, J; Quiniou, L; Laroche, J
Genetic polymorphism and its potential relation to environmental stress in five populations of the European flounder Platichthys flesus, along the French Atlantic coast.
Mar Environ Res
70
201-9
2010
Platichthys, Platichthys flesus
Xue, GP; Snoswell, AM; Runciman, WB
Perturbation of methionine metabolism in sheep with nitrous-oxide-induced inactivation of cobalamin.
Biochem Int
12
61-9
1986
Ovis aries
Evrard, E; Devaux, A; Bony, S; Cachot, J; Charrier, G; Quiniou, L; Laroche, J
Responses of juvenile European flounder (Platichthys flesus) to multistress in the Vilaine estuary, during a 6-month survey.
Environ Sci Pollut Res Int
2012
Platichthys flesus
Uthus, EO; Ross, SA
Dietary selenium affects homocysteine metabolism differently in Fisher-344 rats and CD-1 mice.
J Nutr
137
1132-6
2007
animal, Mus musculus, Mus sp., Rattus
Kwak, HC; Kim, YM; Oh, SJ; Kim, SK
Sulfur amino acid metabolism in Zucker diabetic fatty rats.
Biochem Pharmacol
96
256-66
2015
Rattus, animal
Xue, GP; Snoswell, AM
Disturbance of methyl group metabolism in alloxan-diabetic sheep.
Biochem Int
10
897-905
1985
Ovis aries
Uthus, EO; Yokoi, K; Davis, CD
Selenium deficiency in Fisher-344 rats decreases plasma and tissue homocysteine concentrations and alters plasma homocysteine and cysteine redox status.
J Nutr
132
1122-8
2002
Rattus, Torula
Lysne, V; Bjrndal, B; Vik, R; Nordrehaug, JE; Skorve, J; Nygrd, O; Berge, RK
A Protein Extract from Chicken Reduces Plasma Homocysteine in Rats.
Nutrients
7
4498-511
2015
Rattus, Gallus gallus, Rattus norvegicus
Nechiporuk, V; Zaichko, N; Korda, ?; Melnyk, A; Koloshko, O
SULPHUR-CONTAINING AMINO ACIDS METABOLISM IN EXPERIMENTAL HYPER- AND HYPOTHYROIDISM IN RATS.
Georgian Med News
96-102
2017
Metazoa, Rattus, Transformation
Donohue, TM; Curry-McCoy, TV; Nanji, AA; Kharbanda, KK; Osna, NA; Radio, SJ; Todero, SL; White, RL; Casey, CA
Lysosomal Leakage and Lack of Adaptation of Hepatoprotective Enzyme Contribute to Enhanced Susceptibility to Ethanol-Induced Liver Injury in Female Rats.
Alcohol Clin Exp Res
31
1944-1952
2007
Rattus, Chondrichthyes, Homo sapiens, Metazoa, animal
Ikeda, S; Namekawa, T; Sugimoto, M; Kume, S
Expression of methylation pathway enzymes in bovine oocytes and preimplantation embryos.
J Exp Zool A Ecol Genet Physiol
313
129-36
2010
Bos taurus
Nechyporuk, V; Korda, M; Pentiuk, L; Dmytrenko, I; Bulko, I
The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats.
Pol Merkur Lekarski
48
55-59
2020
Metazoa
You, YA; Lee, JH; Kwon, EJ; Yoo, JY; Kwon, WS; Pang, MG; Kim, YJ
Proteomic Analysis of One-carbon Metabolism-related Marker in Liver of Rat Offspring.
Mol Cell Proteomics
14
2901-9
2015
Rattus
Drobny, A; Meloh, H; Wchtershuser, E; Hellmann, B; Mueller, AS; van der Klis, JD; Fitzenberger, E; Wenzel, U
Betaine-rich sugar beet molasses protects from homocysteine-induced reduction of survival in Caenorhabditis elegans.
Eur J Nutr
2019
Beta vulgaris subsp. vulgaris, Caenorhabditis elegans, Nematoda
Samie, KA; Tabandeh, MR; Afrough, M
Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration.
Syst Biol Reprod Med
1-10
2020
Canis lupus familiaris
King, JH; Kwan, STC; Bae, S; Klatt, KC; Yan, J; Malysheva, OV; Jiang, X; Roberson, MS; Caudill, MA
Maternal choline supplementation alters vitamin B-12 status in human and murine pregnancy.
J Nutr Biochem
72
108210
2019
Homo sapiens
Xie, Y; Liu, J; Benbrahim-Tallaa, L; Ward, JM; Logsdon, D; Diwan, BA; Waalkes, MP
Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic.
Toxicology
236
7-15
2007
Mus musculus
Terruzzi, I; Senesi, P; Montesano, A; La Torre, A; Alberti, G; Benedini, S; Caumo, A; Fermo, I; Luzi, L
Genetic polymorphisms of the enzymes involved in DNA methylation and synthesis in elite athletes.
Physiol Genomics
43
965-73
2011
Athletes
Bucktrout, RE; Ma, N; Aboragah, A; Alharthi, AS; Liang, Y; Lopreiato, V; Lopes, MG; Trevisi, E; Alhidary, IA; Fernandez, C; Loor, JJ
One-carbon, carnitine, and glutathione metabolism-related biomarkers in peripartal Holstein cows are altered by prepartal body condition.
J Dairy Sci
2021
Bos taurus
Yun, KU; Ryu, CS; Lee, JY; Noh, JR; Lee, CH; Lee, HS; Kang, JS; Park, SK; Kim, BH; Kim, SK
Hepatic metabolism of sulfur amino acids in db/db mice.
Food Chem Toxicol
53
180-6
2013
Mus sp.
Jung, YS; Yun, KU; Ryu, CS; Oh, JM; Kwak, HC; Lee, JY; Park, SK; Kim, BH; Oh, SJ; Kim, SK
Alterations in hepatic metabolism of sulfur amino acids in non-obese type-2 diabetic Goto-Kakizaki rats.
Chem Biol Interact
204
80-7
2013
Rattus
Xue, GP; Snoswell, AM
Comparative studies on the methionine synthesis in sheep and rat tissues.
Comp Biochem Physiol B
80
489-94
1985
Ovis aries, Rattus
Lumb, M; Sharer, N; Deacon, R; Jennings, P; Purkiss, P; Perry, J; Chanarin, I
Effects of nitrous oxide-induced inactivation of cobalamin on methionine and S-adenosylmethionine metabolism in the rat.
Biochim Biophys Acta
756
354-9
1983
Rattus
Allen, RH; Stabler, SP; Lindenbaum, J
Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism.
Metabolism
42
1448-60
1993
Homo sapiens
Chadwick, LH; McCandless, SE; Silverman, GL; Schwartz, S; Westaway, D; Nadeau, JH
Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes.
Genomics
70
66-73
2000
Homo sapiens, Mus musculus, Mus sp.
Liu, Y; Liu, YQ; Morita, T; Sugiyama, K
Effects of betaine supplementation and choline deficiency on folate deficiency-induced hyperhomocysteinemia in rats.
J Nutr Sci Vitaminol (Tokyo)
58
69-77
2012
Rattus
Jing, M; Rech, L; Wu, Y; Goltz, D; Taylor, CG; House, JD
Effects of zinc deficiency and zinc supplementation on homocysteine levels and related enzyme expression in rats.
J Trace Elem Med Biol
30
77-82
2015
Rattus
Finkelstein, JD; Martin, JJ
Methionine metabolism in mammals. Adaptation to methionine excess.
J Biol Chem
261
1582-7
1986
Mammalia, Rattus, Metazoa
Finkelstein, JD; Martin, JJ; Harris, BJ
Effect of dietary cystine on methionine metabolism in rat liver.
J Nutr
116
985-90
1986
Rattus
Finkelstein, JD; Martin, JJ; Harris, BJ
Methionine metabolism in mammals. The methionine-sparing effect of cystine.
J Biol Chem
263
11750-4
1988
Mammalia
Junnila, M; Barak, AJ; Beckenhauer, HC; Rahko, T
Betaine reduces hepatic lipidosis induced by carbon tetrachloride in Sprague-Dawley rats.
Vet Hum Toxicol
40
263-6
1998
Metazoa
Slow, S; Lever, M; Lee, MB; George, PM; Chambers, ST
Betaine analogues alter homocysteine metabolism in rats.
Int J Biochem Cell Biol
36
870-80
2004
Homo sapiens
Rodionov, DA; Vitreschak, AG; Mironov, AA; Gelfand, MS
Comparative genomics of the methionine metabolism in Gram-positive bacteria: a variety of regulatory systems.
Nucleic Acids Res
32
3340-53
2004
vertebrata, Oceanobacillus iheyensis
Jacobs, RL; Stead, LM; Devlin, C; Tabas, I; Brosnan, ME; Brosnan, JT; Vance, DE
Physiological regulation of phospholipid methylation alters plasma homocysteine in mice.
J Biol Chem
280
28299-305
2005
Mus sp.
Bai, GQ; Cheng, J; Zhang, SL; Huang, YP; Wang, L; Liu, Y; Lin, SM
Screening of hepatocyte proteins binding to complete S protein of hepatitis B virus by yeast-two hybrid system.
World J Gastroenterol
11
3899-904
2005
Homo sapiens
Slow, S; Vasudevamurthy, M; Fraser, R; McEntyre, C; Lever, M; Chambers, S; George, P
Dimethylthetin treatment causes diffuse alveolar lung damage: a pilot study in a sheep model of Continuous Ambulatory Peritoneal Dialysis (CAPD).
Exp Toxicol Pathol
58
285-90
2007
Ovis aries, Dialysis, Homo sapiens, Metazoa, animal
Lever, M; Atkinson, W; George, PM; Chambers, ST
Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic.
Clin Biochem
40
1225-31
2007
Homo sapiens
Vinci, CR; Clarke, SG
Yeast, Plants, Worms, and Flies Use a Methyltransferase to Metabolize Age-Damaged (R,S)-AdoMet, but What Do Mammals Do?
Rejuvenation Res
2010
Mus musculus, Saccharomyces cerevisiae, Diptera, Mammalia
Qian, YX; Song, JJ
[Effects of salinity and betaine on BHMT mRNA expression in Lateolabrax japonicus].
Dongwuxue Yanjiu
32
277-84
2011
Lateolabrax, Chondrichthyes, Lateolabrax japonicus, Perca flavescens, Lotus japonicus
Yang, SL; Aw, SS; Chang, C; Korzh, S; Korzh, V; Peng, J
Depletion of Bhmt elevates sonic hedgehog transcript level and increases ?-cell number in zebrafish.
Endocrinology
152
4706-17
2011
Danio rerio
Forgacs, AL; Kent, MN; Makley, MK; Mets, B; DelRaso, N; Jahns, GL; Burgoon, LD; Zacharewski, TR; Reo, NV
Comparative metabolomic and genomic analyses of TCDD-elicited metabolic disruption in mouse and rat liver.
Toxicol Sci
125
41-55
2012
Rattus
Neuman, JC; Albright, KA; Schalinske, KL
Exercise prevents hyperhomocysteinemia in a dietary folate-restricted mouse model.
Nutr Res
33
487-93
2013
Mus musculus, Homo sapiens, Mus sp., collection
Xu, L; Huang, D; Hu, Q; Wu, J; Wang, Y; Feng, J
Betaine alleviates hepatic lipid accumulation via enhancing hepatic lipid export and fatty acid oxidation in rats fed with a high-fat diet.
Br J Nutr
113
1835-43
2015
Rattus
Zhang, P; Li, C; Zhang, R; Zhang, W; Jin, C; Wang, L; Song, L
The Roles of Two miRNAs in Regulating the Immune Response of Sea Cucumber.
Genetics
201
1397-410
2015
Cucumis sativus, Vibrio splendidus, Apostichopus japonicus
Martinelli, M; Masiero, E; Carinci, F; Morselli, PG; Pezzetti, F; Scapoli, L
New evidence for the role of cystathionine beta-synthase in non-syndromic cleft lip with or without cleft palate.
Eur J Oral Sci
119
193-7
2011
Homo sapiens
Zhang, Q; Xiao, X; Zheng, J; Li, M; Yu, M; Ping, F; Wang, T; Wang, X
A Possible Mechanism: Vildagliptin Prevents Aortic Dysfunction through Paraoxonase and Angiopoietin-Like 3.
Biomed Res Int
2018
3109251
2018
Rattus
Finkelstein, JD; Martin, JJ; Harris, BJ; Kyle, WE
Regulation of hepatic betaine-homocysteine methyltransferase by dietary betaine.
J Nutr
113
519-21
1983
Rattus
Ueno, T; Ishidoh, K; Mineki, R; Tanida, I; Murayama, K; Kadowaki, M; Kominami, E
Autolysosomal membrane-associated betaine homocysteine methyltransferase. Limited degradation fragment of a sequestered cytosolic enzyme monitoring autophagy.
J Biol Chem
274
15222-9
1999
Rattus
Sowden, MP; Collins, HL; Smith, HC; Garrow, TA; Sparks, JD; Sparks, CE
Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase.
Biochem J
341 ( Pt 3)
639-45
1999
Rattus
Sandu, C; Nick, P; Hess, D; Schiltz, E; Garrow, TA; Brandsch, R
Association of betaine-homocysteine S-methyltransferase with microtubules.
Biol Chem
381
619-22
2000
Rattus, Mammalia
Evans, JC; Huddler, DP; Jiracek, J; Castro, C; Millian, NS; Garrow, TA; Ludwig, ML
Betaine-homocysteine methyltransferase: zinc in a distorted barrel.
Structure (Camb)
10
1159-71
2002
Homo sapiens
Morin, I; Platt, R; Weisberg, I; Sabbaghian, N; Wu, Q; Garrow, TA; Rozen, R
Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida.
Am J Med Genet A
119
172-6
2003
Homo sapiens
Castro, C; Gratson, AA; Evans, JC; Jiracek, J; Collinsová, M; Ludwig, ML; Garrow, TA
Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis.
Biochemistry
43
5341-51
2004
Homo sapiens
Lee, MB; Blunt, JW; Lever, M; George, PM
A nuclear-magnetic-resonance-based assay for betaine-homocysteine methyltransferase activity.
Anal Biochem
330
199-205
2004
Rattus
Zhu, H; Curry, S; Wen, S; Wicker, NJ; Shaw, GM; Lammer, EJ; Yang, W; Jafarov, T; Finnell, RH
Are the betaine-homocysteine methyltransferase (BHMT and BHMT2) genes risk factors for spina bifida and orofacial clefts?
Am J Med Genet A
135
274-7
2005
Homo sapiens
Mostowska, A; Hozyasz, KK; Biedziak, B; Misiak, J; Jagodzinski, PP
Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts.
Eur J Oral Sci
118
325-32
2010
Homo sapiens
Pellanda, H; Namour, F; Fofou-Caillierez, M; Bressenot, A; Alberto, JM; Chry, C; Ayav, A; Bronowicki, JP; Guant, JL; Forges, T
A splicing variant leads to complete loss of function of betaine-homocysteine methyltransferase (BHMT) gene in hepatocellular carcinoma.
Int J Biochem Cell Biol
44
385-92
2012
Homo sapiens, animal
Amorim, MR; Moura, CM; Gomes, AD; Barboza, HN; Lopes, RB; Ribeiro, MG; Costa Lima, MA
Betaine-homocysteine methyltransferase 742G>A polymorphism and risk of down syndrome offspring in a Brazilian population.
Mol Biol Rep
40
4685-9
2013
Homo sapiens
Obeid, R
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway.
Nutrients
5
3481-95
2013
Homo sapiens
Ganu, RS; Ishida, Y; Koutmos, M; Kolokotronis, SO; Roca, AL; Garrow, TA; Schook, LB
Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes.
PLoS One
10
e0134084
2015
Echinoidea, vertebrata, amphibia, Testudines, Primates, Homo sapiens, Deuterostomia, Mammalia
Jin, B; Gong, Z; Yang, N; Huang, Z; Zeng, S; Chen, H; Hu, S; Pan, G
Downregulation of betaine homocysteine methyltransferase (BHMT) in hepatocellular carcinoma associates with poor prognosis.
Tumour Biol
2015
Homo sapiens, Mus sp.
Mulligan JD;Laurie TJ;Garrow TA
An assay for betaine-homocysteine methyltransferase activity based on the microbiological detection of methionine.
The Journal of nutritional biochemistry
9
351-354
1998
Escherichia coli
Dudman, NP; Wilcken, DE; Wang, J; Lynch, JF; Macey, D; Lundberg, P
Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy, and enzymology.
Arterioscler Thromb
13
1253-60
1993
Homo sapiens
Terruzzi, I; Senesi, P; Fermo, I; Lattuada, G; Luzi, L
Are genetic variants of the methyl group metabolism enzymes risk factors predisposing to obesity?
J Endocrinol Invest
30
747-53
2007
Homo sapiens
Mostowska, A; Hozyasz, KK; Wojcicki, P; Dziegelewska, M; Jagodzinski, PP
Associations of folate and choline metabolism gene polymorphisms with orofacial clefts.
J Med Genet
2009
Homo sapiens
DiBello, PM; Dayal, S; Kaveti, S; Zhang, D; Kinter, M; Lentz, SR; Jacobsen, DW
The nutrigenetics of hyperhomocysteinemia: quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocysteinemia.
Mol Cell Proteomics
9
471-85
2010
Homo sapiens, Metazoa, Mus musculus, Mus sp.
Giusti, B; Saracini, C; Bolli, P; Magi, A; Martinelli, I; Peyvandi, F; Rasura, M; Volpe, M; Lotta, LA; Rubattu, S; Mannucci, PM; Abbate, R
Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism.
Thromb Haemost
104
231-42
2010
Homo sapiens
Szczepa?ska, M; Mostowska, A; Wirstlein, P; Lianeri, M; Marianowski, P; Skrzypczak, J; Jagodzi?ski, PP
Polymorphic variants of folate and choline metabolism genes and the risk of endometriosis-associated infertility.
Eur J Obstet Gynecol Reprod Biol
2011
Homo sapiens
Hozyasz, KK; Mostowska, A; Szaflarska-Poplawska, A; Lianeri, M; Jagodzinski, PP
Polymorphic variants of genes involved in homocysteine metabolism in celiac disease.
Mol Biol Rep
2011
Homo sapiens
Jung, J; Ha, TK; Lee, J; Lho, Y; Nam, M; Lee, D; le Roux, CW; Ryu, DH; Ha, E; Hwang, GS
Changes in one-carbon metabolism after duodenal-jejunal bypass surgery.
Am J Physiol Endocrinol Metab
ajpendo.00260.2015
2016
Rattus
Zhang, T; Chen, M; Guo, L; Yu, F; Zhou, C; Xu, H; Wu, B
Reverse Erythroblastosis Virus ? Antagonism Promotes Homocysteine Catabolism and Ammonia Clearance.
Hepatology
2019
Mus sp.
López-Sánchez, LM; Corrales, FJ; Barcos, M; Espejo, I; Muñoz-Castañeda, JR; Rodríguez-Ariza, A
Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis.
Lab Invest
2009
Rattus
Pacana, T; Cazanave, S; Verdianelli, A; Patel, V; Min, HK; Mirshahi, F; Quinlivan, E; Sanyal, AJ
Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease.
PLoS One
10
e0136822
2015
Mus sp.
Tang, X; Cleves, MA; Nick, TG; Li, M; MacLeod, SL; Erickson, SW; Li, J; Shaw, GM; Mosley, BS; Hobbs, CA; ,
Obstructive heart defects associated with candidate genes, maternal obesity, and folic acid supplementation.
Am J Med Genet A
167
1231-42
2015
Homo sapiens
Barak, AJ; Beckenhauer, HC; Tuma, DJ
Hepatic transmethylation and blood alcohol levels.
Alcohol Alcohol
26
125-8
1991
Cricetinae, Mesocricetus auratus, Metazoa
Tsuchiya, H; Ohashi, K
Prevention of alcohol-induced hyperhomocysteinemia by suppression of SHP.
Nihon Arukoru Yakubutsu Igakkai Zasshi
51
323-334
2016
Mus sp.
Zampieri, BL; Biselli, JM; Goloni-Bertollo, EM; Vannucchi, H; Carvalho, VM; Cordeiro, JA; Pavarino, EC
Maternal risk for Down syndrome is modulated by genes involved in folate metabolism.
Dis Markers
32
73-81
2012
Indicator
Hoffmann, L; Brauers, G; Gehrmann, T; Haeussinger, D; Mayatepek, E; Schliess, F; Schwahn, BC
Osmotic regulation of hepatic betaine metabolism.
Am J Physiol Gastrointest Liver Physiol
2013
Mus sp., Rattus
Costa, IR; Thompson, JD; Ortega, JM; Prosdocimi, F
Metazoan remaining genes for essential amino acid biosynthesis: sequence conservation and evolutionary analyses.
Nutrients
7
1-16
2015
Metazoa, plant, Python, Saccharomyces cerevisiae
Barak, AJ; Beckenhauer, HC; Junnila, M; Tuma, DJ
Dietary betaine promotes generation of hepatic S-adenosylmethionine and protects the liver from ethanol-induced fatty infiltration.
Alcohol Clin Exp Res
17
552-5
1993
Rattus, Metazoa
Barak, AJ; Beckenhauer, HC; Tuma, DJ
Betaine effects on hepatic methionine metabolism elicited by short-term ethanol feeding.
Alcohol
13
483-6
0
Rattus
Cao, L; Wang, Y; Zhang, R; Dong, L; Cui, H; Fang, Y; Zhao, L; Shi, O; Cai, C
Association of neural tube defects with gene polymorphisms in one-carbon metabolic pathway.
Childs Nerv Syst
2017
Homo sapiens
Finkelstein, JD
Inborn errors of sulfur-containing amino acid metabolism.
J Nutr
136
1750S-1754S
2006
Homo sapiens
Cohen-Salmon, M; Regnault, B; Cayet, N; Caille, D; Demuth, K; Hardelin, JP; Janel, N; Meda, P; Petit, C
Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis.
Proc Natl Acad Sci U S A
104
6229-34
2007
Mus sp.
Ji, C
Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury.
J Gastroenterol Hepatol
23 Suppl 1
S16-24
2008
Mus musculus
Xu, X; Gammon, MD; Zeisel, SH; Bradshaw, PT; Wetmur, JG; Teitelbaum, SL; Neugut, AI; Santella, RM; Chen, J
High intakes of choline and betaine reduce breast cancer mortality in a population-based study.
FASEB J
2009
Anser, Homo sapiens, animal
Mackay, DS; Brophy, JD; McBreairty, LE; McGowan, RA; Bertolo, RF
Intrauterine growth restriction leads to changes in sulfur amino acid metabolism, but not global DNA methylation, in Yucatan miniature piglets.
J Nutr Biochem
2011
Homo sapiens, Suidae, Sus scrofa, Metazoa
Colomina, JM; Cavall-Busquets, P; Fernndez-Roig, S; Sol-Navais, P; Fernandez-Ballart, JD; Ballesteros, M; Ueland, PM; Meyer, K; Murphy, MM
Maternal Folate Status and the BHMT c.716G>A Polymorphism Affect the Betaine Dimethylglycine Pathway during Pregnancy.
Nutrients
8
2016
Homo sapiens
Idriss, AA; Hu, Y; Sun, Q; Jia, L; Jia, Y; Omer, NA; Abobaker, H; Zhao, R
Prenatal betaine exposure modulates hypothalamic expression of cholesterol metabolic genes in cockerels through modifications of DNA methylation.
Poult Sci
2016
Spondias purpurea
Moore, JR; Hubler, SL; Nelson, CD; Nashold, FE; Spanier, JA; Hayes, CE
1,25-Dihydroxyvitamin D3 increases the methionine cycle, CD4+ T cell DNA methylation and Helios+Foxp3+ T regulatory cells to reverse autoimmune neurodegenerative disease.
J Neuroimmunol
324
100-114
2018
Homo sapiens, Mus sp.
Clare, CE; Pestinger, V; Kwong, WY; Tutt, DAR; Xu, J; Byrne, HM; Barrett, DA; Emes, RD; Sinclair, KD
Interspecific Variation in One-Carbon Metabolism within the Ovarian Follicle, Oocyte, and Preimplantation Embryo: Consequences for Epigenetic Programming of DNA Methylation.
Int J Mol Sci
22
2021
Bos taurus
html completed
