Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Abortion, Habitual
Direct Reprogramming of Mouse Embryonic Fibroblasts to Induced Trophoblast Stem Cells.
Abortion, Spontaneous
Effect of methylenetetrahydrofolate reductase and thymidylate synthase enhancer region polymorphisms on the risk of idiopathic recurrent spontaneous abortion in a Korean population.
Abortion, Spontaneous
Influence of combined methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase enhancer region (TSER) polymorphisms to plasma homocysteine levels in Korean patients with recurrent spontaneous abortion.
Acquired Immunodeficiency Syndrome
The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.
Adenocarcinoma
A pilot study to investigate the role of thymidylate synthase as a marker of prognosis for neoadjuvant chemotherapy in gastric and gastro-oesophageal junction adenocarcinoma.
Adenocarcinoma
A unique case of a patient with rectal cancer who developed benign esophageal stenosis after localized rectal radiation and systemic chemotherapy.
Adenocarcinoma
Activity of thymidylate synthetase and its inhibition by 5-fluorouracil in highly enzyme-overproducing cells resistant to 10-propargyl-5,8-dideazafolate.
Adenocarcinoma
AraC-FdUMP[10] (CF10) is a next generation fluoropyrimidine with potent antitumor activity in PDAC and synergy with PARG inhibition.
Adenocarcinoma
Association of the thymidylate synthase polymorphisms with esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma.
Adenocarcinoma
Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice.
Adenocarcinoma
Comparative analysis of thymidylate synthase at the protein, mRNA, and DNA levels as prognostic markers in colorectal adenocarcinoma.
Adenocarcinoma
Comparison of 5-fluorouracil-related gene expression levels between adenocarcinomas and squamous cell carcinomas of the lung.
Adenocarcinoma
Contrasting patterns of DNA fragmentation induced by thymidylate synthase inhibitors, ZD1694 and AG-331.
Adenocarcinoma
Correlation between histological differentiation and DNA-synthesizing enzymes in rat colorectal tumors induced with 1, 2-dimethylhydrazine.
Adenocarcinoma
Correlation between thymidylate synthase gene variants, RNA and protein levels in primary colorectal adenocarcinomas.
Adenocarcinoma
Detection of circulating lung cancer cells with strong thymidylate synthase reactivity in the peripheral blood of a patient with pulmonary adenocarcinoma treated with pemetrexed.
Adenocarcinoma
Differential expression and prognostic value of ERCC1 and thymidylate synthase in resected gastric adenocarcinoma.
Adenocarcinoma
Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung.
Adenocarcinoma
Effects of 5-fluorouracil derivative UFT on thymidylate synthetase and thymidine kinase in rat colorectal tumors.
Adenocarcinoma
ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy.
Adenocarcinoma
Evaluating the Prognostic Value of ERCC1 and Thymidylate Synthase Expression and the Epidermal Growth Factor Receptor Mutation Status in Adenocarcinoma Non-Small-Cell Lung Cancer.
Adenocarcinoma
Expression of thymidylate synthase in human gastric and colorectal adenocarcinomas is upregulated by p16/INK4.
Adenocarcinoma
Expression of thymidylate synthase in primary colorectal adenocarcinoma.
Adenocarcinoma
Gene dosage and expression, and enzyme activity of thymidine kinase and thymidylate synthase in xenografted colorectal adenocarcinomas.
Adenocarcinoma
Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma.
Adenocarcinoma
Genetic heterogeneity of variable number tandem repeats in thymidylate synthase gene in colorectal cancer patients.
Adenocarcinoma
High pretherapeutic thymidylate synthetase and MRP-1 protein levels are associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patients.
Adenocarcinoma
Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma.
Adenocarcinoma
Histologic subtype in NSCLC: does it matter?
Adenocarcinoma
Histology-Related Associations of ERCC1, RRM1, and TS Biomarkers in Patients with Non-Small-Cell Lung Cancer: Implications for Therapy.
Adenocarcinoma
Immunohistochemical detection of thymidylate synthase in advanced gastric cancer: a prognostic indicator in patients undergoing gastrectomy followed by adjuvant chemotherapy with 5-fluoropyrimidines.
Adenocarcinoma
Immunohistochemical expression of thymidylate synthase as predictor of response to capecitabine in patients with advanced colorectal adenocarcinoma.
Adenocarcinoma
Impact of E2F-1 expression on clinical outcome of gastric adenocarcinoma patients with adjuvant chemoradiation therapy.
Adenocarcinoma
Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independent deletion of superantigen-reactive peripheral T cells.
Adenocarcinoma
Intratumour variation of biomarker expression by immunohistochemistry in resectable non-small cell lung cancer.
Adenocarcinoma
Leucovorin and folic acid regimens for selective expansion of murine 5,10-methylenetetrahydrofolate pools.
Adenocarcinoma
Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil.
Adenocarcinoma
Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line.
Adenocarcinoma
Multicentre phase II pharmacokinetic and pharmacodynamic study of OSI-7904L in previously untreated patients with advanced gastric or gastroesophageal junction adenocarcinoma.
Adenocarcinoma
Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates.
Adenocarcinoma
Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors.
Adenocarcinoma
Phase II trial of ZD1694 (Tomudex) in patients with advanced pancreatic cancer.
Adenocarcinoma
Polymorphism at the 3'-UTR of the thymidylate synthase gene: A potential predictor for outcomes in Caucasian patients with esophageal adenocarcinoma treated with preoperative chemoradiation.
Adenocarcinoma
Predictors of response and survival for neoadjuvant treated patients with esophageal adenocarcinoma.
Adenocarcinoma
Prognostic impact of dihydropyrimidine dehydrogenase expression on pancreatic adenocarcinoma patients treated with S-1-based adjuvant chemotherapy after surgical resection.
Adenocarcinoma
Prognostic implications of thymidylate synthase gene polymorphisms in patients with advanced small bowel adenocarcinoma treated with first-line fluoropyrimidine-based chemotherapy.
Adenocarcinoma
Prognostic significance of thymidylate synthase expression in pancreatic adenocarcinoma: A meta-analysis.
Adenocarcinoma
Prognostic value of p21-activated kinase 4 in resected pancreatic cancer.
Adenocarcinoma
Prognostic value of thymidylate synthase expression in patients with p-stage I adenocarcinoma of the lung.
Adenocarcinoma
Significance of thymidylate synthase expression for resistance to pemetrexed in pulmonary adenocarcinoma.
Adenocarcinoma
Significance of thymidylate synthase gene expression level in patients with adenocarcinoma of the lung.
Adenocarcinoma
Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
Adenocarcinoma
Ternary complex formation and reduced folate in surgical specimens of human adenocarcinoma tissues.
Adenocarcinoma
The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts.
Adenocarcinoma
Thymidylate synthase (TS) gene expression in primary lung cancer patients: a large-scale study in Japanese population.
Adenocarcinoma
Thymidylate synthase and ERCC1 as predictive markers in patients with pulmonary adenocarcinoma treated with pemetrexed and cisplatin.
Adenocarcinoma
Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung.
Adenocarcinoma
Thymidylate synthase expression is closely associated with outcome in patients with pulmonary adenocarcinoma.
Adenocarcinoma
Thymidylate synthase expression, p53, bcl-2, Ki-67 and p27 in colorectal cancer: relationships with tumor recurrence and survival.
Adenocarcinoma
Thymidylate synthase gene polymorphism predicts disease free survival in stage II-III rectal adenocarcinoma patients receiving adjuvant 5-FU-based chemotherapy.
Adenocarcinoma
Thymidylate synthase genotype-directed neoadjuvant chemoradiation for patients with rectal adenocarcinoma.
Adenocarcinoma
Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival.
Adenocarcinoma
Thymidylate synthase polymorphisms and mRNA expression are independent chemotherapy predictive markers in esophageal adenocarcinoma patients.
Adenocarcinoma
Thymidylate synthase prompts metastatic progression through the dTMP associated EMT process in pancreatic ductal adenocarcinoma.
Adenocarcinoma
Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine.
Adenocarcinoma
Thymidylate synthetase activity and fluorouracil sensitivity of human colonic cancer and normal mucosal tissue preparations.
Adenocarcinoma
Time dependence of DNA lesions and growth inhibition by ICI D1694, a new quinazoline antifolate thymidylate synthase inhibitor.
Adenocarcinoma
Updated clinical information on multitargeted antifolates in lung cancer.
Adenocarcinoma
[A Recurrent Case of Thymic Adenocarcinoma Effectively Treated with S-1 Over a Long-Term Period].
Adenocarcinoma
[The evaluation of cellular proliferating activity in gastric carcinoma with the proliferating cell nuclear antigen (PCNA) expressive rate: its fundamental examination of the immunohistochemical procedures and its clinical applications]
Adenocarcinoma of Lung
Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression.
Adenocarcinoma of Lung
Deciphering Clinicoradiologic Phenotype for Thymidylate Synthase Expression Status in Patients with Advanced Lung Adenocarcinoma Using a Radiomics Approach.
Adenocarcinoma of Lung
Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma.
Adenocarcinoma of Lung
Downregulation of thymidylate synthase with arsenic trioxide in lung adenocarcinoma.
Adenocarcinoma of Lung
Efficacy of Pemetrexed-Based Chemotherapy in Patients with ROS1 Fusion-Positive Lung Adenocarcinoma Compared with in Patients Harboring Other Driver Mutations in East Asian Populations.
Adenocarcinoma of Lung
Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobin and MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patients receiving platinum-based chemotherapy.
Adenocarcinoma of Lung
Predictive value of thymidylate synthase for the prognosis and survival of lung adenocarcinoma patients.
Adenocarcinoma of Lung
The influence of methylenetetrahydrofolate reductase and thymidylate synthetase gene polymorphisms on lung adenocarcinoma occurrence.
Adenocarcinoma of Lung
Thymidylate synthase gene copy number as a predictive marker for response to pemetrexed treatment of lung adenocarcinoma.
Adenocarcinoma of Lung
TS expression predicts postoperative recurrence in adenocarcinoma of the lung.
Adenocarcinoma of Lung
[Thymidylate synthase expression and therapeutic effect analysis of pemetrexed in advanced lung adenocarcinoma]
Adenoma
Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase 1, and colorectal adenoma risk: a Dutch case-control study.
Adenoma
Methionine synthase and thymidylate synthase gene polymorphisms and colorectal adenoma risk: The self defense forces study.
Adenoma
Polymorphism in the thymidylate synthase promoter enhancer region and risk of colorectal adenomas.
Adenoma
Thymidylate synthase polymorphisms, folate and B-vitamin intake, and risk of colorectal adenoma.
Adenoma
Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas.
Adenomyosis
Effects of conjugated estrogens with or without medroxyprogesterone acetate on mammary carcinogenesis, uterine adenomyosis and femur in mice.
Adenomyosis
Suppression of spontaneous development of uterine adenomyosis by a Chinese herbal medicine, keishi-bukuryo-gan, in mice.
Adrenal Cortex Neoplasms
Topoisomerase 2? and thymidylate synthase expression in adrenocortical cancer.
Anemia
Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival.
Anemia, Pernicious
Letter: Thymidylate synthetase in pernicious anemia.
Anemia, Pernicious
Thymidylate synthetase activity in bone marrow cells in pernicious anemia.
Anemia, Pernicious
Thymidylate synthetase in pernicious anemia. I.
Anemia, Pernicious
Thymidylate synthetase in pernicious anemia. II.
Arachnoid Cysts
Microarray analysis reveals down-regulation of the tumour suppressor gene WWOX and up-regulation of the oncogene TYMS in intracranial sporadic meningiomas.
Arthritis
Pharmacogenetic study of 5,10-methylenetetrahydrofolate reductase C677T and thymidylate synthase 3R/2R gene polymorphisms and methotrexate-related toxicity in Chinese Han patients with inflammatory arthritis.
Arthritis, Rheumatoid
Are Thymidylate synthase and Methylene tetrahydrofolate reductase genes linked with methotrexate response (efficacy, toxicity) in Indian (Asian) rheumatoid arthritis patients?
Arthritis, Rheumatoid
Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients.
Arthritis, Rheumatoid
Effect of thymidylate synthase (TYMS) gene polymorphisms with methotrexate treatment outcome in south Indian Tamil patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs.
Arthritis, Rheumatoid
Pharmacogenetic study of methylenetetrahydrofolate reductase and thymidylate synthase in Japanese and assessment of ethnic and gender differences.
Arthritis, Rheumatoid
Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis.
Arthritis, Rheumatoid
Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Preliminary study to identify the predictive factors for the response to methotrexate therapy in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Role of key TYMS polymorphisms on methotrexate therapeutic outcome in portuguese rheumatoid arthritis patients.
Arthritis, Rheumatoid
TYMS polymorphisms and responsiveness to or toxicity of methotrexate in rheumatoid arthritis.
Arthritis, Rheumatoid
[Thymidylate synthase genetic polymorphism and plasma total homocysteine level in a group of Turkish patients with rheumatoid arthritis: relationship with disease activity and methotrexate toxicity.]
Ataxia Telangiectasia
P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting.
Bacterial Infections
Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase.
Biliary Tract Neoplasms
Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5-fluorouracil-based chemotherapy.
Biliary Tract Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase are upregulated in pancreatic and biliary tract cancers.
Brain Infarction
The 3'-UTR Polymorphisms in the Thymidylate Synthase (TS) Gene Associated with the Risk of Ischemic Stroke and Silent Brain Infarction.
Brain Neoplasms
Experimental combination chemotherapy with thymidylate synthetase and ribonucleotide reductase inhibitors.
Brain Neoplasms
Polymorphisms of Folate Pathway Enzymes (Methylenetetrahydrofolate Reductase and Thymidylate Synthase) and Their Relationship with Thymidylate Synthase Expression in Human Astrocytic Tumors.
Breast Neoplasms
A Phase I study of raltitrexed and paclitaxel given every 3 weeks to patients with solid tumors.
Breast Neoplasms
A phase II study in advanced breast cancer: ZD1694 ('Tomudex') a novel direct and specific thymidylate synthase inhibitor.
Breast Neoplasms
Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer.
Breast Neoplasms
Antitumor effect of lapatinib and cytotoxic agents by suppression of E2F1 in HER2?positive breast cancer.
Breast Neoplasms
Association between polymorphisms in the thymidylate synthase gene and risk of breast cancer in a Mexican population.
Breast Neoplasms
Biochemical modulation of 5-fluorouracil with leucovorin or delayed uridine rescue. Correlation of antitumor activity with dosage and FUra incorporation into RNA.
Breast Neoplasms
Biomarker expression and druggable gene alterations for development of an appropriate therapeutic protocol for pulmonary adenosquamous carcinoma.
Breast Neoplasms
BRCA1 and XRCC1 polymorphisms associated with survival in advanced gastric cancer treated with taxane and cisplatin.
Breast Neoplasms
Chapter 4 molecular mechanisms of adaptation to folate deficiency.
Breast Neoplasms
Cinnamaldehyde/chemotherapeutic agents interaction and drug-metabolizing genes in colorectal cancer.
Breast Neoplasms
Clinicopathological stages and pyrimidine nucleotide synthesis in human mammary carcinomas.
Breast Neoplasms
Cyclophosphamide augments the anti-tumor efficacy of uracil and tegafur by inhibiting dihydropyrimidine dehydrogenase.
Breast Neoplasms
Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells.
Breast Neoplasms
Diagnostic and prognostic value of thymidylate synthase expression in breast cancer.
Breast Neoplasms
Difference in Ki67 and thymidylate synthase expression in primary tumour compared with metastatic nodes in breast cancer patients.
Breast Neoplasms
Difference in thymidylate synthetase activity in involved nodes compared with primary tumor in breast cancer patients.
Breast Neoplasms
Different expression of thymidylate synthase in primary tumour and metastatic nodes in breast cancer patients.
Breast Neoplasms
DNA-synthesizing enzymes in breast cancer (thymidine kinase, thymidylate synthase and thymidylate kinase): association with flow cytometric S-phase fraction and relative prognostic importance in node-negative premenopausal patients.
Breast Neoplasms
Effect of Simultaneous Inhibition of Protein Kinase CK2 and Thymidylate Synthase in Leukemia and Breast Cancer Cells.
Breast Neoplasms
Enhanced inhibition of thymidylate synthase by 5-fluorouracil and [6S]leucovorin combination therapy for breast cancer.
Breast Neoplasms
Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates.
Breast Neoplasms
Evaluation of sensitivity to 5-FU on the basis of thymidylate synthase (TS)/dihydropyrimidine dehydrogenase (DPD) activity and chromosomal analysis in micro tissue specimens of breast cancer.
Breast Neoplasms
Evaluation of thymidylate synthase RNA expression by polymerase chain reaction.
Breast Neoplasms
Expression of BRCA1, a factor closely associated with relapse-free survival, in patients who underwent neoadjuvant chemotherapy with docetaxel, cisplatin, and fluorouracil for squamous cell carcinoma of the esophagus.
Breast Neoplasms
Expression of Ribonucleotide Reductase Subunit-2 and Thymidylate Synthase Correlates with Poor Prognosis in Patients with Resected Stages I-III Non-Small Cell Lung Cancer.
Breast Neoplasms
Expression of thymidylate synthase and thymidine phosphorylase in human breast carcinoma: implication for method to detect expression of these molecules in clinic.
Breast Neoplasms
Extensive analysis of the molecular biomarkers excision repair cross complementing 1, ribonucleotide reductase M1, ?-tubulin III, thymidylate synthetase, and topoisomerase II? in breast cancer: Association with clinicopathological characteristics.
Breast Neoplasms
Free circulating mRNA in plasma from breast cancer patients and clinical outcome.
Breast Neoplasms
Functional polymorphism of thymidylate synthase, but not of the COMT and IL-1B genes, is associated with breast cancer.
Breast Neoplasms
Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study.
Breast Neoplasms
Immunolocalization of thymidylate synthase as a favorable prognostic marker in estrogen receptor-positive breast carcinoma.
Breast Neoplasms
Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independent mechanisms.
Breast Neoplasms
Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells.
Breast Neoplasms
Influence of thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms on the disease-free survival of breast cancer patients receiving adjuvant 5-fluorouracil/methotrexate-based therapy.
Breast Neoplasms
Intratumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase in non-small cell lung cancer patients treated with 5-FU-based chemotherapy.
Breast Neoplasms
MDR1 and thymidylate synthase (TS) gene expressions in advanced breast cancer: relationships to drug exposure, p53 mutations, and clinical outcome of the patients.
Breast Neoplasms
Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype.
Breast Neoplasms
Pemetrexed: translational research in breast cancer.
Breast Neoplasms
Phase II study of the antifolate N10-propargyl-5,8-dideazafolic acid (CB 3717) in advanced breast cancer.
Breast Neoplasms
Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis.
Breast Neoplasms
Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study.
Breast Neoplasms
Prognostic importance of thymidylate synthase expression in early breast cancer.
Breast Neoplasms
Proteomics of Sentinel Lymph Nodes in Early Breast Cancer for Identification of Thymidylate Synthase as a Potential Biomarker to Flag Metastasis: A Preliminary Study.
Breast Neoplasms
Relationship between thymidylate synthase (TYMS) gene polymorphism and TYMS protein levels in patients with high-risk breast cancer.
Breast Neoplasms
Relationship between thymidylate synthase and p53 and response to FEC versus taxane adjuvant chemotherapy for breast carcinoma.
Breast Neoplasms
Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.
Breast Neoplasms
The prognostic significance of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in breast carcinomas.
Breast Neoplasms
The raltitrexed-vinorelbine combination: a phase I pharmacokinetic and pharmacodynamic trial in advanced breast cancer.
Breast Neoplasms
Thymidine kinase and thymidylate synthase in advanced breast cancer: response to tamoxifen and chemotherapy.
Breast Neoplasms
Thymidine labeling index of human breast carcinoma. Enhancement of in vitro labeling by 5-fluorouracil and 5-fluoro-2'-deoxyuridine.
Breast Neoplasms
Thymidine phosphorylase and dihydropyrimidine dehydrogenase are predictive factors of therapeutic efficacy of capecitabine monotherapy for breast cancer-preliminary results.
Breast Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in breast cancer predicts 5-FU sensitivity by a histocultural drug sensitivity test.
Breast Neoplasms
Thymidylate synthase and thymidine phosphorylase as predictive markers of capecitabine monotherapy in patients with anthracycline- and taxane-pretreated metastatic breast cancer.
Breast Neoplasms
Thymidylate synthase gene (TYMS) polymorphisms in sporadic and hereditary breast cancer.
Breast Neoplasms
Thymidylate synthase gene polymorphisms effecting 5-FU response in breast cancer patients.
Breast Neoplasms
Thymidylate synthase levels as a therapeutic and prognostic predictor in breast cancer.
Breast Neoplasms
Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers.
Breast Neoplasms
Thymidylate synthase predicts for clinical outcome in invasive breast cancer.
Breast Neoplasms
Thymidylate synthase predicts poor response to pemetrexed chemotherapy in patients with advanced breast cancer.
Breast Neoplasms
Transcriptional Activation of Thymidylate Synthase by 17?-Estradiol in MCF-7 Human Breast Cancer Cells.
Breast Neoplasms
Transcriptional activation of thymidylate synthase by 17beta-estradiol in MCF-7 human breast cancer cells.
Breast Neoplasms
Translational research with pemetrexed in breast cancer.
Breast Neoplasms
[A preliminary study on dihydropyrimidine dehydrogenase activity in breast cancer]
Breast Neoplasms
[Estimation of level of enzyme induction of thymidine phosphorylase, dihydropyrimidine dehydrogenase, and thymidylate synthase in primary and recurrent breast cancer]
Breast Neoplasms
[Expressions of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase in breast cancer and their correlations with prognosis.]
Breast Neoplasms
[Relationships among the expression of thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase and the prognosis of breast cancer]
Breast Neoplasms
[Significance of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) activity in breast cancer tissue]
Breast Neoplasms
[Significance of tissue PyNPase, TS, and DPD activities in breast cancer]
Breast Neoplasms
[Standardization and quality control in the evaluation of proliferation parameters in T1T2, N0N1, M0 breast cancer : multicentric retrospective study I. DNA synthesis enzyme activities]
Breast Neoplasms
[Standardization and quality control in the evaluation of proliferation parameters in T1T2, N0N1, M0 breast cancer: multicentric retrospective study II. DNA-ploidy and S-phase fraction]
Carcinogenesis
Effects of conjugated estrogens with or without medroxyprogesterone acetate on mammary carcinogenesis, uterine adenomyosis and femur in mice.
Carcinogenesis
Effects of long-term administration of UFT plus leucovorin on colorectal tumors induced with 1,2-dimethylhydrazine in rats.
Carcinogenesis
Folate-related nutrients, genetic polymorphisms, and colorectal cancer risk: the fukuoka colorectal cancer study.
Carcinogenesis
Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival.
Carcinoma
5-Ethoxy-2'-deoxyuridine, a novel substrate for thymidine phosphorylase, potentiates the antitumor activity of 5-fluorouracil when used in combination with interferon, an inducer of thymidine phosphorylase expression.
Carcinoma
5-Fluorouracil and UFT-sensitive gastric carcinoma has a high level of thymidylate synthase.
Carcinoma
7-Hydro-8-methylpteroylglutamylglutamic acid, a new anti-folate from an actinomycete. Fermentation, isolation, structure and biological activity.
Carcinoma
A comparison of the effects of antitumor agents upon normal human epidermal keratinocytes and human squamous cell carcinoma.
Carcinoma
A phase 1 study of TRC102, an inhibitor of base excision repair, and pemetrexed in patients with advanced solid tumors.
Carcinoma
Acyclic analogues of 5-fluoro-dUMP and 5-fluoro-2'-deoxyuridine: synthesis and inhibition of thymidylate synthase and tumour cell growth.
Carcinoma
Altered thymidylate synthetase in 5-fluorodeoxyuridine-resistant Ehrlich ascites carcinoma cells.
Carcinoma
Alternative chemoradiotherapy in anal carcinoma patients with mutations in thymidylate synthase and dihydropyrimidine dehydrogenase genes.
Carcinoma
Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
Carcinoma
Antitumour effects of pure diastereoisomers of 5-formyltetrahydrofolate in hepatic transplants of a rodent colon carcinoma model.
Carcinoma
Association between dietary folate intake and clinical outcome in head and neck squamous cell carcinoma.
Carcinoma
Association of gastric and intestinal phenotypic marker expression of gastric carcinomas with tumor thymidylate synthase expression and response to postoperative chemotherapy with 5-fluorouracil.
Carcinoma
Association of the thymidylate synthase polymorphisms with esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma.
Carcinoma
Associations between gene polymorphisms of thymidylate synthase with its protein expression and chemosensitivity to 5-fluorouracil in pancreatic carcinoma cells.
Carcinoma
AZT: a biochemical response modifier of methotrexate and 5-fluorouracil cytotoxicity in human ovarian and pancreatic carcinoma cells.
Carcinoma
Biochemical and molecular properties of cisplatin-resistant A2780 cells grown in folinic acid.
Carcinoma
Calcium and calcium sensing receptor modulates the expression of thymidylate synthase, NAD(P)H:quinone oxidoreductase 1 and survivin in human colon carcinoma cells: Promotion of cytotoxic response to mitomycin C and fluorouracil.
Carcinoma
Changes of gene expression of thymidine phosphorylase, thymidylate synthase, dihydropyrimidine dehydrogenase after the administration of 5'-deoxy-5-fluorouridine, paclitaxel and its combination in human gastric cancer xenografts.
Carcinoma
Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.
Carcinoma
Clinical relevance of thymidylate synthase (TS) activity for S-1-based chemotherapy in squamous cell carcinoma of the oral cavity.
Carcinoma
Clinical value of thymidine kinase in patients with cervical carcinoma.
Carcinoma
Clinicopathological stages and pyrimidine nucleotide synthesis in human mammary carcinomas.
Carcinoma
Comparison of 5-fluorouracil-related gene expression levels between adenocarcinomas and squamous cell carcinomas of the lung.
Carcinoma
Comparison of the inhibitory effects of hydroxyurea, 5-fluorodeoxyuridine, 3,4-dihydroxybenzylamine, and methotrexate on human squamous cell carcinoma.
Carcinoma
Comparison of the mRNA expression of factors related to drug resistance in lung tumors and adjacent normal tissue.
Carcinoma
Concurrent allopurinol and 5-fluorouracil: 5-fluoro-2'-deoxyuridylate formation and thymidylate synthase inhibition in rat colon carcinoma and in regenerating rat liver.
Carcinoma
Correlations between thymidylate synthase expression and chemosensitivity to 5-fluorouracil, cell proliferation and clinical outcome in head and neck squamous cell carcinoma.
Carcinoma
Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor 1843U89 at physiological thymidine concentrations.
Carcinoma
Different pathways of 5-fluorouracil metabolism after continuous venous or bolus injection in patients with colon carcinoma: possible predictive value of thymidylate synthetase mRNA and ribonucleotide reductase for 5-fluorouracil sensitivity.
Carcinoma
Differential oncogene amplification in tumor cells from a patient treated with cisplatin and 5-fluorouracil.
Carcinoma
Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung.
Carcinoma
DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells.
Carcinoma
Do thymidylate synthase gene promoter polymorphism and the C/G single nucleotide polymorphism predict effectiveness of adjuvant 5-fluorouracil-based chemotherapy in stage III colonic adenocarcinoma?
Carcinoma
Down-regulation of c-myc gene expression with induction of high molecular weight DNA fragments by fluorodeoxyuridine.
Carcinoma
Effect of Uridine on the Metabolism of 5-Fluorouracil in the CD8F 1 Murine Mammary Carcinoma System.
Carcinoma
Effects of combined administration of DPD-inhibitory oral fluoropyrimidine, S-1, plus paclitaxel on gene expressions of fluoropyrimidine metabolism-related enzymes in human gastric xenografts.
Carcinoma
Effects of kampo (Japanese herbal) medicine "sho-saiko-to" on DNA-synthesizing enzyme activity in 1,2-dimethylhydrazine-induced colonic carcinomas in rats.
Carcinoma
Effects of Mg2+ and adenine nucleotides on thymidylate synthetase from different mouse tumors.
Carcinoma
Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma.
Carcinoma
Effects of smoking and alcohol consumption on 5-fluorouracil-related metabolic enzymes in oral squamous cell carcinoma.
Carcinoma
Elevated expression of thymidylate synthase cycle genes in cisplatin-resistant human ovarian carcinoma A2780 cells.
Carcinoma
Elevated expression of thymidylate synthase in doxorubicin resistant human non small cell lung carcinomas.
Carcinoma
Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery.
Carcinoma
Establishment of mutant FM3A murine mammary carcinoma cell strains transformed with the herpes simplex virus type 1 thymidine kinase gene.
Carcinoma
Evaluation of thymidylate synthase protein expression by Western blotting and immunohistochemistry on human colon carcinoma xenografts in nude mice.
Carcinoma
Evaluation of Tomudex in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Southwest Oncology Group study.
Carcinoma
Evaluation of TS-1 based treatment and expression of thymidylate synthase and dihydropyrimidine dehydrogenase on oral squamous cell carcinoma.
Carcinoma
Expression levels of thymidylate synthase, thymidylate phosphorylase and dihydropyrimidine dehydrogenase in head and neck squamous cell carcinoma: preliminary study.
Carcinoma
Expression of ERCC1, TYMS, TUBB3, RRM1 and TOP2A in patients with esophageal squamous cell carcinoma: A hierarchical clustering analysis.
Carcinoma
Expression of genes involved in chemoresistance, proliferation and apoptosis in clinical samples of renal cell carcinoma and correlation with clinical outcome.
Carcinoma
Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in adenoid cystic carcinoma of the head and neck: correlation with clinical outcome.
Carcinoma
Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in oral squamous cell carcinoma: possible markers as predictors of clinical outcome.
Carcinoma
Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in primary oral squamous cell carcinoma and corresponding metastases in cervical lymph nodes: association with the metastasis suppressor CD82.
Carcinoma
Expression of thymidylate synthase and glutathione-s-transferase pi in patients with esophageal squamous cell carcinoma.
Carcinoma
Expression of topoisomerase II, catalase, metallothionein and thymidylate-synthase in human squamous cell lung carcinomas and their correlation with doxorubicin resistance and with patients' smoking habits.
Carcinoma
Expression profiling-based subtyping identifies novel non-small cell lung cancer subgroups and implicates putative resistance to pemetrexed therapy.
Carcinoma
Extensive analysis of the molecular biomarkers excision repair cross complementing 1, ribonucleotide reductase M1, ?-tubulin III, thymidylate synthetase, and topoisomerase II? in breast cancer: Association with clinicopathological characteristics.
Carcinoma
FLUORINATED PYRIMIDINES. XXV. THE INHIBITION OF THYMIDYLATE SYNTHETASE FROM EHRLICH ASCITES CARCINOMA CELLS BY PYRIMIDINE ANALOGS.
Carcinoma
Genetic polymorphisms in folate- metabolizing enzymes and risk of gastroesophageal cancers: a potential nutrient-gene interaction in cancer development.
Carcinoma
Gossypol sensitizes the antitumor activity of 5-FU through down-regulation of thymidylate synthase in human colon carcinoma cells.
Carcinoma
High expression of thymidylate synthase is associated with the drug resistance of gastric carcinoma to high dose 5-fluorouracil-based systemic chemotherapy.
Carcinoma
High expression of thymidylate synthase leads to resistance to 5-fluorouracil in biliary tract carcinoma in vitro.
Carcinoma
High-grade neuroendocrine carcinoma of the lung shows increased thymidylate synthase expression compared to other histotypes.
Carcinoma
Histology-Related Associations of ERCC1, RRM1, and TS Biomarkers in Patients with Non-Small-Cell Lung Cancer: Implications for Therapy.
Carcinoma
Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer.
Carcinoma
Immunohistochemical analysis of thymidylate synthase expression in gastric carcinoma: correlation with clinicopathological parameters and survival.
Carcinoma
Immunohistochemical detection of thymidylate synthase in advanced gastric cancer: a prognostic indicator in patients undergoing gastrectomy followed by adjuvant chemotherapy with 5-fluoropyrimidines.
Carcinoma
Immunohistochemical evaluation of thymidylate synthase in gastric carcinoma using a new polyclonal antibody: the clinical role of thymidylate synthase as a prognostic indicator and its therapeutic usefulness.
Carcinoma
Impact of intratumoral thymidylate synthase expression on prognosis after surgical resection for ampullary carcinoma.
Carcinoma
Increased thymidine kinase and thymidylate synthase activities in human epithelial ovarian carcinoma.
Carcinoma
Increased thymidylate synthase (EC 2.1.1.45) activity in normal and neoplastic proliferation.
Carcinoma
Inhibition of apoptosis after thymineless stress is conferred by oncogenic K-Ras in colon carcinoma cells.
Carcinoma
Inhibition of mammalian tumour thymidylate synthetase by 2'-deoxyuridine 5'-phosphate analogues.
Carcinoma
Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat.
Carcinoma
Inhibition of thymidylate synthetase of Walker carcinoma by chlorambucil. A possible mechanism of action.
Carcinoma
Interaction between Gambogic acid and dihydrofolate reductase and synergistic lethal effects with methotrexate on hepatoma cells.
Carcinoma
Interferon alpha-2a shows antitumor activity in combination with 5-fluorouracil against human colon carcinoma xenografts: a study in reference to thymidylate synthetase activity inhibition.
Carcinoma
Interferon beta increases antitumor activity of 5-fluorouracil against human colon carcinoma cells in vitro and in vivo.
Carcinoma
Intratumoural expression of thymidylate synthase is an independent predictor of prognosis in patients with squamous cell carcinoma of the tongue: results from a retrospective study.
Carcinoma
Investigation of the prognostic and predictive value of thymidylate synthase, p53, and Ki-67 in patients with locally advanced colon cancer.
Carcinoma
Levels and expressions of orotate phosphoribosyltransferase in gastric carcinoma and normal gastric mucosa tissues.
Carcinoma
Loss of heterozygosity at thymidylate synthase locus in Barrett's metaplasia, dysplasia, and carcinoma sequences.
Carcinoma
Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole.
Carcinoma
Mechanism of inhibition of mammalian tumor and other thymidylate synthases by N4-hydroxy-dCMP, N4-hydroxy-5-fluoro-dCMP, and related analogues.
Carcinoma
Methotrexate decreases thymidine kinase activity.
Carcinoma
Modulation of multidrug resistance in human ovarian cancer cell lines by inhibition of P-glycoprotein 170 and PKC isoenzymes with antisense oligonucleotides.
Carcinoma
Modulation of target enzyme associated with the action of antifolates.
Carcinoma
Nifedipine synergizes with calcium in activating the calcium sensing receptor, suppressing the expression of thymidylate synthase and survivin and promoting sensitivity to fluorouracil in human colon carcinoma cells.
Carcinoma
P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells.
Carcinoma
Pathological features and pyrimidine nucleotide synthesis in human gastric carcinomas.
Carcinoma
Phase II Study of Pemetrexed as a Salvage Chemotherapy for Thymidylate Synthase-Low Squamous Cell Lung Cancer.
Carcinoma
Polymorphisms of 5,10-methylenetetrahydrofolate reductase and thymidylate synthase in squamous cell carcinoma and basal cell carcinoma of the skin.
Carcinoma
Potentiation of quinazoline antifolate (CB3717) toxicity by dipyridamole in human lung carcinoma, A549, cells.
Carcinoma
Predictive value of immunohistochemical thymidylate synthase expression for histological response to Tegafur/Uracil (UFT) in oral squamous cell carcinoma.
Carcinoma
Preoperative radiotherapy and concomitant capecitabine treatment induce thymidylate synthase and thymidine phosphorylase mRNAs in rectal carcinoma.
Carcinoma
Prognostic significance of thymidylate synthase activity in bladder carcinoma.
Carcinoma
Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study.
Carcinoma
Properties of thymidylate synthetase from Ehrlich ascites carcinoma cells. Effect of Mg2/ and MgATP2-.
Carcinoma
Protein Expression Profiles Indicative for Drug Resistance of Kidney Carcinoma.
Carcinoma
Purification and properties of mouse thymus thymidylate synthase. Comparison of the enzyme from mammalian normal and tumour tissues.
Carcinoma
Purification of thymidylate synthetase from Ehrlich ascites carcinoma cells.
Carcinoma
Quantification of thymidylate synthase gene expression in human gastrointestinal carcinoma tissues using competitive PCR.
Carcinoma
Radiosensitization by fluorodeoxyuridine: effects of thymidylate synthase inhibition and cell synchronization.
Carcinoma
Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method.
Carcinoma
Relationship between immunohistochemical evaluation of thymidylate synthase and proliferating cell nuclear antigen labeling index in gastrointestinal carcinoma.
Carcinoma
Relative activities of thymidylate synthetase and thymidine kinase in 1,2-dimethylhydrazine-induced colon carcinomas in rats.
Carcinoma
Relative level of thymidylate synthase mRNA expression in primary tumors and normal tissues predicts survival of patients with oral tongue squamous cell carcinoma.
Carcinoma
Resistance mechanisms and their regulation in lung cancer.
Carcinoma
Resistance to methotrexate in thymidylate synthetase-deficient mutants of cultured mouse mammary tumor FM3A cells.
Carcinoma
Role of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in gallbladder carcinoma.
Carcinoma
Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514.
Carcinoma
Sequential methotrexate/5-FU: FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma.
Carcinoma
Significance of thymidine kinase activity in renal cell carcinoma.
Carcinoma
Significance of thymidylate synthase activity in renal cell carcinoma.
Carcinoma
Spermidine/spermine N1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines.
Carcinoma
Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase.
Carcinoma
Study of Thymidylate Synthase (TS) and Dihydropyrimidine Dehydrogenase (DPD) Expressions on 5-Fluorouracil in Oral Squamous Cell Carcinoma
Carcinoma
Synergistic antitumour effect of raltitrexed and 5-fluorouracil plus folinic acid combination in human cancer cells.
Carcinoma
Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.
Carcinoma
The combined-action of ici-d1694, 5-fluoro-2'-deoxyuridine and 5-Fluorouracil in inhibiting the growth of a human renal-cell carcinoma cell-line (rpmi-se) in-vitro.
Carcinoma
The effect of cyclic nucleotides on DNA polymerase, thymidylate synthetase, thymidine kinase and deoxynucleoside levels of Waler carcinoma.
Carcinoma
The effect of neoadjuvant therapy on the 5-fluorouracil metabolic and relative enzymes of oral squamous cell carcinoma.
Carcinoma
The novel heterodinucleoside dimer 5-FdU-NOAC is a potent cytotoxic drug and a p53-independent inducer of apoptosis in the androgen-independent human prostate cancer cell lines PC-3 and DU-145.
Carcinoma
The potentiation of radiation response in human colon carcinoma cells in vitro and murine lymphoma in vivo by AG337 (Thymitaq), a novel thymidylate synthase inhibitor.
Carcinoma
The Prognostic Value of Thymidylate Synthase and p53 Expression in Patients Treated with Induction Chemotherapy for Squamous Cell Carcinoma of the Head and Neck.
Carcinoma
The quantitation by radioimmunoassay of 2'-deoxyuridine 5'-triphosphate in extracts of thymidylate synthase-inhibited cells.
Carcinoma
Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model.
Carcinoma
Thymidylate synthase 1 (ts1) in-situ protein expression predicts the survival of ewing/pnet.
Carcinoma
Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck.
Carcinoma
Thymidylate synthase activity, folates, and glutathione system in head and neck carcinoma and adjacent tissues.
Carcinoma
Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: The association with treatment efficacy of pemetrexed.
Carcinoma
Thymidylate synthase and dihydropyrimidine dehydrogenase expression in oral squamous cell carcinoma: an immunohistochemical and clinicopathologic study.
Carcinoma
Thymidylate synthase and dihydropyrimidine dehydrogenase expressions in gallbladder cancer.
Carcinoma
Thymidylate synthase as a target for growth inhibition in methotrexate-sensitive and -resistant human head and neck cancer and leukemia cell lines.
Carcinoma
Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung.
Carcinoma
Thymidylate synthase expression as a predictor of clinical response to 5-fluorouracil-based chemoradiotherapy in patients with maxillary sinus squamous cell carcinoma.
Carcinoma
Thymidylate synthase expression as a predictor of the prognosis of curatively resected colon carcinoma in patients registered in an adjuvant immunochemotherapy clinical trial.
Carcinoma
Thymidylate synthase expression in colon carcinomas with microsatellite instability.
Carcinoma
Thymidylate synthase expression in oral squamous cell carcinoma predicts response to S-1.
Carcinoma
Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
Carcinoma
Thymidylate synthase messenger RNA expression in plasma from patients with colon cancer: prognostic potential.
Carcinoma
Thymidylate synthase, thymidine phosphorylase and orotate phosphoribosyl transferase levels as predictive factors of chemotherapy in oral squamous cell carcinoma.
Carcinoma
Thymidylate synthetase (TS) genotype and TS/dihydropyrimidine dehydrogenase mRNA level as an indicator in determining chemosensitivity to 5-fluorouracil in advanced gastric carcinoma.
Carcinoma
Thymidylate synthetase activity and fluorouracil sensitivity of human colonic cancer and normal mucosal tissue preparations.
Carcinoma
Thymidylate synthetase allelic imbalance in clear cell renal carcinoma.
Carcinoma
Thymidylate synthetase and dihydropyrimidine dehydrogenase mRNA levels in esophageal cancer.
Carcinoma
Thymidylate synthetase and thymidine kinase activities in DMH-induced colon carcinomas in rats and effects of UFT.
Carcinoma
Thymidylate synthetase-positive and -negative murine mammary FM3A carcinoma cells as a useful system for detecting thymidylate synthetase inhibitors.
Carcinoma
Thymineless death in colon carcinoma cells is mediated via fas signaling.
Carcinoma
Vitamin D mediates its action in human colon carcinoma cells in a calcium-sensing receptor-dependent manner: Downregulates malignant cell behavior and the expression of thymidylate synthase and survivin and promotes cellular sensitivity to 5-FU.
Carcinoma
Where should the specimen be excised for the chemosensitivity of colorectal cancer to 5-fluorouracil?
Carcinoma
[Assessment of dihydropyrimidine dehydrogenase and thymidylate synthase expression in gastric carcinoma and colonic carcinoma]
Carcinoma
[Association of thymidylate synthase polymorphism with esophageal squamous-cell carcinoma]
Carcinoma
[Development of new treatment modalities for advanced head and neck carcinomas]
Carcinoma
[Dihydropyrimidine dehydrogenase and thymidylate synthase in colon carcinoma]
Carcinoma
[Effects of hyperthermochemotherapy on activities of DNA-synthesizing enzymes in 1, 2-dimethylhydrazine (DMH)-induced colon carcinomas in rats]
Carcinoma
[ERCC1 and TS expression in chemoradiotherapy treated esophageal squamous cell carcinoma].
Carcinoma
[Orotate phosphoribosyltransferase levels in gastric carcinoma and normal gastric mucosa - correlation with thymidylate synthase and dihydropyrimidine dehydrogenase levels and the changes after neoadjuvant chemotherapy.]
Carcinoma
[Polymorphisms of thymidylate synthase gene and correlation of its protein expression to lymph node metastasis of esophageal squamous cell carcinoma]
Carcinoma
[Potentiation of thymidylate synthetase (TS) inhibition by combined administration of HCFU and dipyridamole: preliminary report. Kinki Cooperative Study Group of Chemotherapy for Colorectal Carcinoma]
Carcinoma
[Thymidylate synthase expression in patients with hypopharyngeal carcinoma]
Carcinoma
[Thymidylate synthase inhibition and concentration of 5-fluorouracil after administration of UFT in human uroepithelial carcinomas]
Carcinoma, Adenoid Cystic
Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma.
Carcinoma, Adenoid Cystic
Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in adenoid cystic carcinoma of the head and neck: correlation with clinical outcome.
Carcinoma, Adenosquamous
Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung.
Carcinoma, Basal Cell
Polymorphisms of 5,10-methylenetetrahydrofolate reductase and thymidylate synthase in squamous cell carcinoma and basal cell carcinoma of the skin.
Carcinoma, Ductal
Clinical analysis of 21-gene recurrence score test in hormone receptor-positive early-stage breast cancer.
Carcinoma, Ductal
Implication of thymidylate synthase in the outcome of patients with invasive ductal carcinoma of the pancreas and efficacy of adjuvant chemotherapy using 5-fluorouracil or its derivatives.
Carcinoma, Ductal
Neuroendocrine Breast Carcinomas Share Prognostic Factors with Gastroenteropancreatic Neuroendocrine Tumors: A Putative Prognostic Role of Menin, p27, and SSTR-2A.
Carcinoma, Ehrlich Tumor
Dihydrofluorouracil, a fluorouracil catabolite with antitumor activity in murine and human cells.
Carcinoma, Ehrlich Tumor
Purification and characterization of thymidylate synthetase in the liver of the mouse bearing Ehrlich ascites tumor.
Carcinoma, Ehrlich Tumor
Synthetic inhibitors of Escherichia coli, calf thymus, and Ehrlich ascites tumor thymidylate synthetase.
Carcinoma, Ehrlich Tumor
Thymidylate synthetase and thymidine kinase activities and methotrexate cytotoxicity during growth of L1210 and Ehrlich ascites tumor.
Carcinoma, Ehrlich Tumor
Thymidylate synthetase inhibitors. Synthesis of N-substituted 5-aminomethyl-2'-deoxyuridine 5'-phosphates.
Carcinoma, Hepatocellular
A Case-Control Study on the Correlation Between Thymidylate Synthase Gene Polymorphisms and Raltitrexed Treatment Combined with Transcatheter Arterial Chemoembolization in Hepatocellular Carcinoma Treatment.
Carcinoma, Hepatocellular
A Phase II trial of nolatrexed dihydrochloride in patients with advanced hepatocellular carcinoma.
Carcinoma, Hepatocellular
Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver.
Carcinoma, Hepatocellular
Assessment of pegylated arginine deiminase and modified FOLFOX6 in patients with advanced hepatocellular carcinoma: Results of an international, single-arm, phase 2 study.
Carcinoma, Hepatocellular
Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
Carcinoma, Hepatocellular
Cell cycle patterns of thymidylate synthetase and 5,10-methylenetetrahydrofolate polyglutamates in cultured mouse hepatoma cells.
Carcinoma, Hepatocellular
Clinical significance of the thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase mRNA expressions in hepatocellular carcinoma patients receiving 5-fluorouracil-based transarterial chemoembolization treatment.
Carcinoma, Hepatocellular
Dihydropyrimidine dehydrogenase and thymidylate synthase activities in hepatocellular carcinomas and in diseased livers.
Carcinoma, Hepatocellular
Elevated levels of mRNAs encoding dihydropyrimidine dehydrogenase and thymidylate synthase are associated with improved survival of patients with hepatocellular carcinoma treated with S-1.
Carcinoma, Hepatocellular
Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds.
Carcinoma, Hepatocellular
Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma.
Carcinoma, Hepatocellular
High thymidylate synthase gene expression predicts poor outcome after resection of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Increased thymidylate synthase (EC 2.1.1.45) activity in normal and neoplastic proliferation.
Carcinoma, Hepatocellular
Increased thymidylate synthetase in 5-fluorodeoxyuridine resistant cultured hepatoma cells.
Carcinoma, Hepatocellular
Induction of remission in hepatocellular carcinoma with a new thymidylate synthase inhibitor, CB3717. A phase II study.
Carcinoma, Hepatocellular
Inhibition of mammalian thymidylate synthase by 10-formyltetrahydropteroylpolyglutamate.
Carcinoma, Hepatocellular
Inhibition of the growth of human hepatocellular carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate synthase, CB3717.
Carcinoma, Hepatocellular
Intracellular location of thymidylate synthase and its state of phosphorylation.
Carcinoma, Hepatocellular
Isolation and expression of rat thymidylate synthase cDNA: phylogenetic comparison with human and mouse thymidylate synthases.
Carcinoma, Hepatocellular
Methotrexate decreases thymidine kinase activity.
Carcinoma, Hepatocellular
Modulation of 5-fluorouracil cytotoxicity through thymidylate synthase and NF-kappaB down-regulation and its application on the radiolabelled iododeoxyuridine therapy on human hepatoma cell.
Carcinoma, Hepatocellular
Nucleotide interconversions. IV. Activities of deoxycytidylate deaminase and thymidylate synthetase in normal rat liver and hepatomas.
Carcinoma, Hepatocellular
Preclinical evaluation of locoregional delivery of radiolabeled iododeoxyuridine and thymidylate synthase inhibitor in a hepatoma model.
Carcinoma, Hepatocellular
Regulation of de novo and salvage pathways in chemotherapy.
Carcinoma, Hepatocellular
Significance of dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expressions in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Simple separation of tritiated water and [3H]deoxyuridine from [5-3H]deoxyuridine 5'-monophosphate in the thymidylate synthase assay.
Carcinoma, Hepatocellular
Suberoylanilide hydroxamic acid enhances chemosensitivity to 5-fluorouracil in hepatocellular carcinoma via inhibition of thymidylate synthase.
Carcinoma, Hepatocellular
Synthesis and biological activity of N(alpha)-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid.
Carcinoma, Hepatocellular
The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihydrofolate reductase.
Carcinoma, Hepatocellular
Thymidylate synthase gene polymorphisms as important contributors affecting hepatocellular carcinoma prognosis.
Carcinoma, Hepatocellular
[Study on the pharmacokinetics of UFT in patients with hepatocellular carcinoma associated with cirrhosis]
Carcinoma, Neuroendocrine
High-grade neuroendocrine carcinoma of the lung shows increased thymidylate synthase expression compared to other histotypes.
Carcinoma, Neuroendocrine
[Basic and translational research progress of gastrointestinal neuroendocrine neoplasmas].
Carcinoma, Non-Small-Cell Lung
Antimetabolites and cancer: emerging data with a focus on antifolates.
Carcinoma, Non-Small-Cell Lung
Association between EML4-ALK fusion gene and thymidylate synthase mRNA expression in non-small cell lung cancer tissues.
Carcinoma, Non-Small-Cell Lung
Association between expression of thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase and efficacy of pemetrexed in advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Association between TYMS Expression and Efficacy of Pemetrexed-Based Chemotherapy in Advanced Non-Small Cell Lung Cancer: A Meta-Analysis.
Carcinoma, Non-Small-Cell Lung
Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC.
Carcinoma, Non-Small-Cell Lung
Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression.
Carcinoma, Non-Small-Cell Lung
Chemotherapy followed by surgery on the basis of biomarker examination for patients with advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Correlation of Expression Levels of Copper Transporter 1 and Thymidylate Synthase with Treatment Outcomes in Patients with Advanced Non-small Cell Lung Cancer Treated with S-1/Carboplatin Doublet Chemotherapy
Carcinoma, Non-Small-Cell Lung
Deciphering Clinicoradiologic Phenotype for Thymidylate Synthase Expression Status in Patients with Advanced Lung Adenocarcinoma Using a Radiomics Approach.
Carcinoma, Non-Small-Cell Lung
Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Differences in the efficacy of S-1 monotherapy according to histological type in pretreated patients with advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung.
Carcinoma, Non-Small-Cell Lung
Downregulation of thymidylate synthase with arsenic trioxide in lung adenocarcinoma.
Carcinoma, Non-Small-Cell Lung
Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging.
Carcinoma, Non-Small-Cell Lung
Early detection of thymidylate synthase resistance in non-small cell lung cancer with FLT-PET imaging.
Carcinoma, Non-Small-Cell Lung
Effect of thymidylate synthase gene polymorphism on the response to chemotherapy and clinical outcome of non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Expression and pharmacological inhibition of thymidylate synthase and Src kinase in nonsmall cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS).
Carcinoma, Non-Small-Cell Lung
Expression of Ribonucleotide Reductase Subunit-2 and Thymidylate Synthase Correlates with Poor Prognosis in Patients with Resected Stages I-III Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Expression of thymidylate synthase in human non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Expression of thymidylate synthase is correlated with proliferative activity in non-small cell lung cancer (NSCLC).
Carcinoma, Non-Small-Cell Lung
High-grade neuroendocrine carcinoma of the lung shows increased thymidylate synthase expression compared to other histotypes.
Carcinoma, Non-Small-Cell Lung
Inhibition of dUTPase Induces Synthetic Lethality with Thymidylate Synthase-Targeted Therapies in Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Intratumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase in non-small cell lung cancer patients treated with 5-FU-based chemotherapy.
Carcinoma, Non-Small-Cell Lung
Multiplex real-time PCR for RRM1, XRCC1, TUBB3 and TS mRNA for prediction of response of non-small cell lung cancer to chemoradiotherapy.
Carcinoma, Non-Small-Cell Lung
Pemetrexed disodium (Eli Lilly).
Carcinoma, Non-Small-Cell Lung
Pemetrexed for previously treated patients with non-small cell lung cancer and differences in efficacy according to thymidylate synthase expression.
Carcinoma, Non-Small-Cell Lung
Pemetrexed induced thymidylate synthase inhibition in non-small cell lung cancer patients: a pilot study with 3'-deoxy-3'-[¹?F]fluorothymidine positron emission tomography.
Carcinoma, Non-Small-Cell Lung
Pemetrexed/Carboplatin/Bevacizumab followed by Maintenance Pemetrexed/Bevacizumab in Hispanic Patients with Non-Squamous Non-Small Cell Lung Cancer: Outcomes according to Thymidylate Synthase Expression.
Carcinoma, Non-Small-Cell Lung
Pharmacologic inhibition of mTOR antagonizes the cytotoxic activity of pemetrexed in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Plasma thymidylate synthase and dihydrofolate reductase mRNA levels as potential predictive biomarkers of pemetrexed sensitivity in patients with advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Polymorphisms in thymidylate synthase and reduced folate carrier (SLC19A1) genes predict survival outcome in advanced non-small cell lung cancer patients treated with pemetrexed-based chemotherapy.
Carcinoma, Non-Small-Cell Lung
Predictive and Prognostic Value of 18F-fluorodeoxyglucose Uptake Combined with Thymidylate Synthase Expression in Patients with Advanced Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Predictive Significance of Thymidylate Synthase Expression in Non-small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase expression in tumor tissue, regarding the efficacy of postoperatively administered UFT (tegafur+uracil) in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic and predictive significance of thymidylate synthase protein expression in non-small cell lung cancer: a systematic review and meta-analysis.
Carcinoma, Non-Small-Cell Lung
Prognostic significance of the mRNA expression of ERCC1, RRM1, TUBB3 and TYMS genes in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Prognostic value of ERCC1, RRM1, and TS proteins in patients with resected non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Protein and mRNA expression of folic acid-associated enzymes as biomarkers for the cytotoxicity of the thymidylate synthase-targeted drugs, pemetrexed and S-1, in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Significance of Thymidylate Synthase and Thyroid Transcription Factor 1 Expression in Patients with Nonsquamous Non-small Cell Lung Cancer Treated with Pemetrexed-Based Chemotherapy.
Carcinoma, Non-Small-Cell Lung
Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of gefitinib-induced down-regulation of thymidylate synthase.
Carcinoma, Non-Small-Cell Lung
The deubiquitinating enzyme UCHL1 promotes resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase.
Carcinoma, Non-Small-Cell Lung
The efficacy of pemetrexed as a third- or fourth-line therapy and the significance of thymidylate synthase expression in patients with advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
The novel thymidylate synthase inhibitor trifluorothymidine (TFT) and TRAIL synergistically eradicate non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
The pemetrexed-containing treatments in the non-small cell lung cancer, is -/low thymidylate synthase expression better than +/high thymidylate synthase expression: a meta-analysis.
Carcinoma, Non-Small-Cell Lung
The role of thymidylate synthase in non-small cell lung cancer treated with pemetrexed continuation maintenance therapy.
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: The association with treatment efficacy of pemetrexed.
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase and dihydropyrimidine dehydrogenase activities in non-small cell lung cancer tissues: relationship with in vitro sensitivity to 5-fluorouracil.
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase and dihydropyrimidine dehydrogenase expression levels are associated with response to S-1 plus carboplatin in advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase and dihydropyrimidine dehydrogenase in non-small cell lung cancer: relationship between mRNA expression and activity.
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase expression as a predictive biomarker of pemetrexed sensitivity in advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase expression in high-grade neuroendocrine and non-small cell lung cancer histotypes--is it ready for primetime?
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase expression is closely associated with outcome in patients with pulmonary adenocarcinoma.
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase gene amplification predicts pemetrexed resistance in patients with advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase inhibitors for non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase polymorphisms are associated to therapeutic outcome of advanced non-small cell lung cancer patients treated with platinum-based chemotherapy.
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase polymorphisms in genomic DNA as clinical outcome predictors in a European population of advanced non-small cell lung cancer patients receiving pemetrexed.
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase protein expression by IHC and gene copy number by SISH correlate and show great variability in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Thymidylate synthase protein expression levels remain stable during paclitaxel and carboplatin treatment in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Up-regulation of ERK1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
[Effect of pemetrexed plus platinum for chemotherapy-naive advanced non-small cell lung cancer].
Carcinoma, Ovarian Epithelial
Increased thymidine kinase and thymidylate synthase activities in human epithelial ovarian carcinoma.
Carcinoma, Ovarian Epithelial
Polymorphic thymidylate synthase gene impacts on overall survival of patients with epithelial ovarian cancer after platinum-based chemotherapy.
Carcinoma, Ovarian Epithelial
Relationship between the expression of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase and survival in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Thymidylate synthase expression in epithelial ovarian cancer: relationship with thymidine phosphorylase expression and prognosis.
Carcinoma, Pancreatic Ductal
Implication of thymidylate synthase in the outcome of patients with invasive ductal carcinoma of the pancreas and efficacy of adjuvant chemotherapy using 5-fluorouracil or its derivatives.
Carcinoma, Renal Cell
Expression of genes involved in chemoresistance, proliferation and apoptosis in clinical samples of renal cell carcinoma and correlation with clinical outcome.
Carcinoma, Renal Cell
Significance of thymidine kinase activity in renal cell carcinoma.
Carcinoma, Renal Cell
Significance of thymidylate synthase activity in renal cell carcinoma.
Carcinoma, Renal Cell
The combined-action of ici-d1694, 5-fluoro-2'-deoxyuridine and 5-Fluorouracil in inhibiting the growth of a human renal-cell carcinoma cell-line (rpmi-se) in-vitro.
Carcinoma, Renal Cell
Thymidylate synthetase allelic imbalance in clear cell renal carcinoma.
Carcinoma, Squamous Cell
A comparison of the effects of antitumor agents upon normal human epidermal keratinocytes and human squamous cell carcinoma.
Carcinoma, Squamous Cell
Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
Carcinoma, Squamous Cell
Association between dietary folate intake and clinical outcome in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.
Carcinoma, Squamous Cell
Clinical relevance of thymidylate synthase (TS) activity for S-1-based chemotherapy in squamous cell carcinoma of the oral cavity.
Carcinoma, Squamous Cell
Comparison of 5-fluorouracil-related gene expression levels between adenocarcinomas and squamous cell carcinomas of the lung.
Carcinoma, Squamous Cell
Comparison of the inhibitory effects of hydroxyurea, 5-fluorodeoxyuridine, 3,4-dihydroxybenzylamine, and methotrexate on human squamous cell carcinoma.
Carcinoma, Squamous Cell
Correlations between thymidylate synthase expression and chemosensitivity to 5-fluorouracil, cell proliferation and clinical outcome in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung.
Carcinoma, Squamous Cell
Evaluation of Tomudex in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Southwest Oncology Group study.
Carcinoma, Squamous Cell
Expression levels of thymidylate synthase, thymidylate phosphorylase and dihydropyrimidine dehydrogenase in head and neck squamous cell carcinoma: preliminary study.
Carcinoma, Squamous Cell
Expression profiling-based subtyping identifies novel non-small cell lung cancer subgroups and implicates putative resistance to pemetrexed therapy.
Carcinoma, Squamous Cell
Histology-Related Associations of ERCC1, RRM1, and TS Biomarkers in Patients with Non-Small-Cell Lung Cancer: Implications for Therapy.
Carcinoma, Squamous Cell
In-vitro differential metabolism and activity of 5-fluorouracil between short-term, high-dose and long-term, low-dose treatments in human squamous carcinoma cells.
Carcinoma, Squamous Cell
Intratumoural expression of thymidylate synthase is an independent predictor of prognosis in patients with squamous cell carcinoma of the tongue: results from a retrospective study.
Carcinoma, Squamous Cell
Phase II Study of Pemetrexed as a Salvage Chemotherapy for Thymidylate Synthase-Low Squamous Cell Lung Cancer.
Carcinoma, Squamous Cell
Polymorphisms of 5,10-methylenetetrahydrofolate reductase and thymidylate synthase in squamous cell carcinoma and basal cell carcinoma of the skin.
Carcinoma, Squamous Cell
Relative level of thymidylate synthase mRNA expression in primary tumors and normal tissues predicts survival of patients with oral tongue squamous cell carcinoma.
Carcinoma, Squamous Cell
Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase.
Carcinoma, Squamous Cell
Synergistic antitumour effect of raltitrexed and 5-fluorouracil plus folinic acid combination in human cancer cells.
Carcinoma, Squamous Cell
Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.
Carcinoma, Squamous Cell
The Prognostic Value of Thymidylate Synthase and p53 Expression in Patients Treated with Induction Chemotherapy for Squamous Cell Carcinoma of the Head and Neck.
Carcinoma, Squamous Cell
Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck.
Carcinoma, Squamous Cell
Thymidylate synthase as a target for growth inhibition in methotrexate-sensitive and -resistant human head and neck cancer and leukemia cell lines.
Carcinoma, Squamous Cell
Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung.
Carcinoma, Squamous Cell
Thymidylate synthase expression as a predictor of clinical response to 5-fluorouracil-based chemoradiotherapy in patients with maxillary sinus squamous cell carcinoma.
Carcinosarcoma
Evaluation of 1-(3,4-dichlorophenyl)-4-dimethylaminomethyl-1-nonen-3-one hydrochloride effect on nucleic acid and protein syntheses using murine leukemia L-1210 cells.
Cardiotoxicity
Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity.
Cardiotoxicity
Uridine Triacetate for Severe Fluoropyrimidine Cardiotoxicity in a Patient With Thymidylate Synthase Gene Variants.
Cardiovascular Diseases
A simple and fast LC-MS/MS method with a very high sensitivity for the measurement of raltitrexed in human plasma.
Chickenpox
Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine.
Cholangiocarcinoma
FOXM1 modulates 5-fluorouracil sensitivity in cholangiocarcinoma through thymidylate synthase (TYMS): implications of FOXM1-TYMS axis uncoupling in 5-FU resistance.
Cholangiocarcinoma
Polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and thymidylate synthase enhancer region (TSER) as a risk factor of cholangiocarcinoma in a Korean population.
Cholangiocarcinoma
Retraction Note to: FOXM1 modulates 5-fluorouracil sensitivity in cholangiocarcinoma through thymidylate synthase (TYMS): implications of FOXM1-TYMS axis uncoupling in 5-FU resistance.
Cholangiocarcinoma
Role of dihydropyrimidine dehydrogenase and thymidylate synthase expression in immunohistochemistry of intrahepatic cholangiocarcinoma.
Cholangiocarcinoma
Role of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA in intrahepatic cholangiocarcinoma.
Cholera
Attenuation of bacterial virulence by quorum sensing-regulated lysis.
Choriocarcinoma
Thymidylate synthase mRNA expression does not predict resistance to floxuridine in a choriocarcinoma cell line.
Coccidiosis
Thymidylate synthetase as a chemotherapeutic target in the treatment of avian coccidiosis.
Colonic Neoplasms
A Combined Analysis of Mismatch Repair Status and Thymidylate Synthase Expression in Stage II and III Colon Cancer.
Colonic Neoplasms
A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803.
Colonic Neoplasms
Accomplishments in 2007 in biologic markers for gastrointestinal cancers.
Colonic Neoplasms
Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer.
Colonic Neoplasms
Anticancer effects of a Chinese herbal medicine, juzen-taiho-to, in combination with or without 5-fluorouracil derivative on DNA-synthesizing enzymes in 1,2-dimethylhydrazine induced colonic cancer in rats.
Colonic Neoplasms
AQUA analysis of thymidylate synthase reveals localization to be a key prognostic biomarker in 2 large cohorts of colorectal carcinoma.
Colonic Neoplasms
Binding of 5-fluorodeoxyuridylate to thymidylate synthase in human colon adenocarcinoma xenografts.
Colonic Neoplasms
Biochemical modulation of fluorouracil with leucovorin and interferon: preclinical and clinical investigations.
Colonic Neoplasms
Cell cycle control processes determine cytostasis or cytotoxicity in thymineless death of colon cancer cells.
Colonic Neoplasms
Characteristics of thymidylate synthase purified from a human colon adenocarcinoma.
Colonic Neoplasms
Characterization and drug sensitivity of four newly established colon adenocarcinoma cell lines to antifolate inhibitors of thymidylate synthase.
Colonic Neoplasms
Characterization of the pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in xenografts of human colon adenocarcinoma.
Colonic Neoplasms
Combination of 5-fluorouracil and irinotecan on modulation of thymidylate synthase and topoisomerase I expression and cell cycle regulation in human colon cancer LoVo cells: clinical relevance.
Colonic Neoplasms
Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines.
Colonic Neoplasms
Combination studies with 3'-azido-3'-deoxythymidine (AZT) plus ICI D1694. Cytotoxic and biochemical effects.
Colonic Neoplasms
Comparison of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in the treatment of murine colon cancer; effects on thymidylate synthase.
Colonic Neoplasms
Detection and quantitation of thymidylate synthase mRNA in human colon adenocarcinoma cell line resistant to 5-fluorouracil by competitive PCR.
Colonic Neoplasms
Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
Colonic Neoplasms
Development and characterization of a human colon adenocarcinoma xenograft deficient in thymidine salvage.
Colonic Neoplasms
Down-regulation of thymidylate synthase expression and its steady-state mRNA by oxaliplatin in colon cancer cells.
Colonic Neoplasms
Effect of 2'-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells.
Colonic Neoplasms
Effect of leucovorin on 5-fluorouracil induced inhibition of thymidylate synthase in patients with colon cancer.
Colonic Neoplasms
Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft.
Colonic Neoplasms
Effects of 5,8-dideazaisopteroylglutamate and its possible tri-gamma-glutamyl metabolite (5,8-dideazaisoPteGlu3) on colon adenocarcinoma, and the folate dependent enzymes thymidylate synthase and dihydrofolate reductase.
Colonic Neoplasms
Effects of ligand binding and conformational switching on intracellular stability of human thymidylate synthase.
Colonic Neoplasms
Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer.
Colonic Neoplasms
Elevated Microsatellite Alterations at Selected Tetranucleotide Repeats (EMAST) and Microsatellite Instability in Patients with Colorectal Cancer and Its Clinical Features.
Colonic Neoplasms
Elevation of radiolabelled thymidine uptake in RIF-1 fibrosarcoma and HT29 colon adenocarcinoma cells after treatment with thymidylate synthase inhibitors.
Colonic Neoplasms
Enzyme prodrug gene therapy: synergistic use of the herpes simplex virus-cellular thymidine kinase/ganciclovir system and thymidylate synthase inhibitors for the treatment of colon cancer.
Colonic Neoplasms
Fluoropyrimidine-mediated radiosensitization depends on cyclin E-dependent kinase activation.
Colonic Neoplasms
Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer.
Colonic Neoplasms
Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts.
Colonic Neoplasms
Histone deacetylase inhibitors suppress thymidylate synthase gene expression and synergize with the fluoropyrimidines in colon cancer cells.
Colonic Neoplasms
Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells.
Colonic Neoplasms
Humoral immune response to thymidylate synthase in colon cancer patients after 5-FU chemotherapy.
Colonic Neoplasms
Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs.
Colonic Neoplasms
Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells.
Colonic Neoplasms
Identification of in vivo target RNA sequences bound by thymidylate synthase.
Colonic Neoplasms
Immunoassay for thymidylate synthase in cytosols from human colorectal-carcinoma cell-lines.
Colonic Neoplasms
Immunohistochemical determination of p53 protein does not predict clinical response in advanced colorectal cancer with low thymidylate synthase expression receiving a bolus 5-fluorouracil-leucovorin combination.
Colonic Neoplasms
Improved synthetic routes to 5,8-dideazapteroylglutamates amenable to the formation of poly-gamma-L-glutamyl derivatives.
Colonic Neoplasms
In vitro and in vivo inhibition of thymidylate synthase of human colon cancer by 5-fluorouracil.
Colonic Neoplasms
In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.
Colonic Neoplasms
Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells.
Colonic Neoplasms
Induction of CaSR expression circumvents the molecular features of malignant CaSR null colon cancer cells.
Colonic Neoplasms
Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression.
Colonic Neoplasms
Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines.
Colonic Neoplasms
Influence of dose of [6RS]leucovorin on reduced folate pools and 5-fluorouracil-mediated thymidylate synthase inhibition in human colon adenocarcinoma xenografts.
Colonic Neoplasms
Investigation of the prognostic and predictive value of thymidylate synthase, p53, and Ki-67 in patients with locally advanced colon cancer.
Colonic Neoplasms
Irinotecan overcomes the resistance to 5-fluorouracil in human colon cancer xenografts by down-regulation of intratumoral thymidylate synthase.
Colonic Neoplasms
Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase.
Colonic Neoplasms
Logistic regression model of the clinical response to 5-fluorouracil based chemotherapy for metastatic colorectal cancer patients.
Colonic Neoplasms
Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability.
Colonic Neoplasms
Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed.
Colonic Neoplasms
Molecular Predictors of Lymph Node Metastasis in Colon Cancer: Increased Risk With Decreased Thymidylate Synthase Expression.
Colonic Neoplasms
Multi-level gene expression profiles affected by thymidylate synthase and 5-FU in colon cancer.
Colonic Neoplasms
Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency.
Colonic Neoplasms
Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates.
Colonic Neoplasms
p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site.
Colonic Neoplasms
Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients.
Colonic Neoplasms
Polymorphism of thymidylate synthase gene associated with its protein expression in human colon cancer.
Colonic Neoplasms
Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer.
Colonic Neoplasms
Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients.
Colonic Neoplasms
Prognostic and predictive value of thymidylate synthase expression in colon cancer.
Colonic Neoplasms
Prognostic value of thymidylate synthase, epidermal growth factor receptors and vascular endothelial growth factor in patients with stage III colon cancer.
Colonic Neoplasms
Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study.
Colonic Neoplasms
Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers.
Colonic Neoplasms
Ratio of 2'-deoxyadenosine-5'-triphosphate/thymidine-5'-triphosphate influences the commitment of human colon carcinoma cells to thymineless death.
Colonic Neoplasms
Regulation of p53 expression by thymidylate synthase.
Colonic Neoplasms
Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma.
Colonic Neoplasms
Relationship between 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthase activity subsequent to 5-fluorouracil administration, in xenografts of human colon adenocarcinomas.
Colonic Neoplasms
Role of biological markers in the clinical outcome of colon cancer.
Colonic Neoplasms
Safety and antitumor activity of arsenic trioxide plus infusional 5-fluorouracil, leucovorin, and irinotecan as second-line chemotherapy for refractory metastatic colorectal cancer: A pilot study from South India.
Colonic Neoplasms
Synergy between the non-classical thymidylate synthase inhibitor AG337 (Thymitaq) and cisplatin in human colon and ovarian cancer cells.
Colonic Neoplasms
Tamoxifen and gonadal steroids inhibit colon cancer growth in association with inhibition of thymidylate synthase, survivin and telomerase expression through estrogen receptor beta mediated system.
Colonic Neoplasms
The effect of dose and interval between 5-fluorouracil and leucovorin on the formation of thymidylate synthase ternary complex in human cancer cells.
Colonic Neoplasms
The transfection of thymidylate synthase antisense suppresses oncogenic properties of a human colon cancer cell line and augments the antitumor effect of fluorouracil.
Colonic Neoplasms
Thymidilate synthase expression predicts longer survival in patients with stage II colon cancer treated with 5-flurouracil independently of microsatellite instability.
Colonic Neoplasms
Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro.
Colonic Neoplasms
Thymidylate synthase expression and p21(WAF1)/p53 phenotype of colon cancers identify patients who may benefit from 5-fluorouracil based therapy.
Colonic Neoplasms
Thymidylate synthase expression correlates closely with E2F1 expression in colon cancer.
Colonic Neoplasms
Thymidylate synthase expression in stage II and III colon cancer: a retrospective review.
Colonic Neoplasms
Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil.
Colonic Neoplasms
Thymidylate synthase gene polymorphism as a prognostic factor for colon cancer.
Colonic Neoplasms
Thymidylate synthase genotyping is more predictive for therapy response than immunohistochemistry in patients with colon cancer.
Colonic Neoplasms
Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer.
Colonic Neoplasms
Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil.
Colonic Neoplasms
Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines.
Colonic Neoplasms
Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
Colonic Neoplasms
Thymidylate synthase messenger RNA expression in plasma from patients with colon cancer: prognostic potential.
Colonic Neoplasms
Thymidylate synthase polymorphism in Mexican patients with colon cancer treated with 5-fluorouracil.
Colonic Neoplasms
Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival.
Colonic Neoplasms
Thymidylate synthase protein and p53 mRNA form an in vivo ribonucleoprotein complex.
Colonic Neoplasms
Thymidylate synthase protein expression in advanced colon cancer: correlation with the site of metastasis and the clinical response to leucovorin-modulated bolus 5-fluorouracil.
Colonic Neoplasms
Thymidylate synthetase activity and fluorouracil sensitivity of human colonic cancer and normal mucosal tissue preparations.
Colonic Neoplasms
Treatment of metastatic colorectal carcinoma. Recent advances in use of fluorouracil.
Colonic Neoplasms
TS gene polymorphisms are not good markers of response to 5-FU therapy in stage III colon cancer patients.
Colonic Neoplasms
Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use.
Colonic Neoplasms
Uptake and metabolism of 5,8-dideazaisofolic acid in human colon carcinoma cells.
Colonic Neoplasms
Vascular endothelial growth factor expression, S-phase fraction and thymidylate synthase quantitation in node-positive colon cancer: relationships with tumor recurrence and resistance to adjuvant chemotherapy.
Colonic Neoplasms
[Analysis of the salvage synthesis within biosynthesis of nucleic acid route in colon cancer]
Colonic Neoplasms
[Detection of thymidylate synthase mRNA in 5-fluorouracil resistant human colon adenocarcinoma cells]
Colonic Neoplasms
[Dihydropyrimidine dehydrogenase and thymidylate synthase activities in colonic cancer tissue and sensitivity to 5-fluorouracil]
Colonic Neoplasms
[Significance of thymidylate synthase and dihydropyrimidine dehydrogenase activity in colon cancer]
Colonic Neoplasms
[The effect of UFT on thymidine kinase and thymidylate synthetase activities and autoradiograph in DMH-induced colon cancer in rat]
Colonic Neoplasms
[The intratumoral levels of thymidylate synthetase and folate in gastric and colon cancer]
Colorectal Neoplasms
3'-UTR Polymorphisms in Thymidylate Synthase with Colorectal Cancer Prevalence and Prognosis.
Colorectal Neoplasms
3R Variant of Thymidylate Synthase 5'-untranslated Enhanced Region Contributes to Colorectal Cancer Risk: A Meta-analysis.
Colorectal Neoplasms
5' and 3' UTR thymidylate synthase polymorphisms modulate the risk of colorectal cancer independently of the intake of methyl group donors.
Colorectal Neoplasms
5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers.
Colorectal Neoplasms
A new prognostic factor for colorectal carcinoma, thymidylate synthase, and its therapeutic significance.
Colorectal Neoplasms
A phase I and pharmacokinetic study of OSI-7904L, a liposomal thymidylate synthase inhibitor in combination with oxaliplatin in patients with advanced colorectal cancer.
Colorectal Neoplasms
A phase I/II trial of vorinostat in combination with 5-fluorouracil in patients with metastatic colorectal cancer who previously failed 5-FU-based chemotherapy.
Colorectal Neoplasms
A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil.
Colorectal Neoplasms
A practical approach for assessing chemosensitivity in colorectal cancer cell lines by comparative analysis of cell viability and thymidylate synthase mRNA expression.
Colorectal Neoplasms
A prospective, blinded analysis of thymidylate synthase and p53 expression as prognostic markers in the adjuvant treatment of colorectal cancer.
Colorectal Neoplasms
A randomized trial comparing defined-duration with continuous irinotecan until disease progression in fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer.
Colorectal Neoplasms
A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803.
Colorectal Neoplasms
Activity of thymidylate synthetase, thymidine kinase and galactokinase in primary and xenografted human colorectal cancers in relation to their chromosomal patterns.
Colorectal Neoplasms
Age-dependent effects of floxuridine (FUdR) on senescent pathology and mortality in the nematode Caenorhabditis elegans.
Colorectal Neoplasms
Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients.
Colorectal Neoplasms
Amplification of thymidylate synthetase in metastatic colorectal cancer patients pretreated with 5-fluorouracil-based chemotherapy.
Colorectal Neoplasms
An integrated analysis of the association between Ts gene polymorphisms and clinical outcome in gastric and colorectal cancer patients treated with 5-FU-based regimens.
Colorectal Neoplasms
Analysis of the mRNA Expression Levels of Thymidylate Synthase (TS), Dihydropyrimidine Dehydrogenase (DPD) and Orotate Phosphoribosyl Transferase (OPRT) in Liver Metastases from Colorectal Cancer.
Colorectal Neoplasms
Analysis of the thymidylate synthase gene structure in colorectal cancer patients and its possible relation with the 5-Fluorouracil drug response.
Colorectal Neoplasms
Analysis of uracil DNA glycosylase in human colorectal cancer.
Colorectal Neoplasms
AQUA analysis of thymidylate synthase reveals localization to be a key prognostic biomarker in 2 large cohorts of colorectal carcinoma.
Colorectal Neoplasms
Arsenic trioxide suppresses thymidylate synthase in 5-FU-resistant colorectal cancer cell line HT29 In Vitro re-sensitizing cells to 5-FU.
Colorectal Neoplasms
Association between p53 expression and Bcl-2, P-glycoprotein, topoisomerase II alpha, thymidylate synthase and thymidine phosphorylase as potential therapeutic targets in colorectal cancer patients.
Colorectal Neoplasms
Association of time to recurrence with thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression in stage II and III colorectal cancer.
Colorectal Neoplasms
Associations between polymorphisms in the thymidylate synthase gene, the expression of thymidylate synthase mRNA and the microsatellite instability phenotype of colorectal cancer.
Colorectal Neoplasms
Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity.
Colorectal Neoplasms
Bcl-2 expression significantly correlates with thymidylate synthase expression in colorectal cancer patients.
Colorectal Neoplasms
Capecitabine-mediated heart failure in colorectal cancer: a case series.
Colorectal Neoplasms
Carboplatin in combination with raltitrexed in recurrent and metastatic head and neck squamous cell carcinoma: A multicentre phase II study of the Gruppo Oncologico Dell'Italia Meridionale (G.O.I.M.).
Colorectal Neoplasms
Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.
Colorectal Neoplasms
CES2, ABCG2, TS and Topo-I primary and synchronous metastasis expression and clinical outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI regimen.
Colorectal Neoplasms
Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.
Colorectal Neoplasms
Changes in thymidylate synthase mRNA in blood leukocytes from patients with colorectal cancer after bolus administration of 5-fluorouracil.
Colorectal Neoplasms
Characterisation of a synergistic interaction between a thymidylate synthase inhibitor, ZD1694, and a novel lipophilic topoisomerase I inhibitor karenitecin, BNP1100: mechanisms and clinical implications.
Colorectal Neoplasms
Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens.
Colorectal Neoplasms
Chemotherapy of colorectal cancer: history and new themes.
Colorectal Neoplasms
Chronic exposure of colorectal cancer cells in culture to fluoropyrimidine analogs induces thymidylate synthase and suppresses p53. A molecular explanation for the mechanism of 5-FU resistance.
Colorectal Neoplasms
Clinical and preclinical pharmacokinetics of raltitrexed.
Colorectal Neoplasms
Clinical colorectal cancer: thymidylate synthase as a molecular biomarker.
Colorectal Neoplasms
Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy.
Colorectal Neoplasms
Clinical relevance of thymidylate synthase expression in the signet ring cell histotype component of colorectal carcinoma.
Colorectal Neoplasms
Clinically relevant drug-drug interactions in oncology.
Colorectal Neoplasms
Colorectal cancer: the challenge.
Colorectal Neoplasms
Colorectal carcinomas with microsatellite instability display increased thymidylate synthase gene expression levels.
Colorectal Neoplasms
Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.
Colorectal Neoplasms
Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells.
Colorectal Neoplasms
Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer.
Colorectal Neoplasms
Combination of polymorphisms within 5' and 3' untranslated regions of thymidylate synthase gene modulates survival in 5 fluorouracil-treated colorectal cancer patients.
Colorectal Neoplasms
Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan.
Colorectal Neoplasms
Comparative analysis of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in colorectal cancer and surrounding normal tissue.
Colorectal Neoplasms
Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors.
Colorectal Neoplasms
Coptidis Rhizoma Extract Reverses 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells via Modulation of Thymidylate Synthase.
Colorectal Neoplasms
Copy-number analysis of topoisomerase and thymidylate synthase genes in frozen and FFPE DNAs of colorectal cancers.
Colorectal Neoplasms
Correlation between thymidylate synthase protein expression and gene polymorphism with clinicopathological parameters in colorectal carcinoma.
Colorectal Neoplasms
Correlations between expression levels of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase, and efficacy of 5-fluorouracil-based chemotherapy for advanced colorectal cancer.
Colorectal Neoplasms
Correlations of Clinicopathological Factors with Protein Expression Levels of Thymidylate Synthase, Dihydropyrimidine Dehydrogenase and Orotate Phosphoribosyltransferase in Colorectal Cancer.
Colorectal Neoplasms
Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance.
Colorectal Neoplasms
Detection of thymidylate synthase expression in lymph node metastases of colorectal cancer can improve the prognostic information.
Colorectal Neoplasms
Differential expression of thymidylate synthase in colorectal tumors and matched lymph nodes: impact on adjuvant treatment.
Colorectal Neoplasms
Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.
Colorectal Neoplasms
Dihydropyrimidine dehydrogenase activity and thymidylate synthase level are associated with response to 5-fluorouracil in human colorectal cancer.
Colorectal Neoplasms
Dihydropyrimidine dehydrogenase and thymidylate synthase polymorphisms and their association with 5-fluorouracil/leucovorin chemotherapy in colorectal cancer.
Colorectal Neoplasms
Dihydropyrimidine dehydrogenase but not thymidylate synthase expression is associated with resistance to 5-fluorouracil in colorectal cancer.
Colorectal Neoplasms
Distribution of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase.
Colorectal Neoplasms
Do the expression of CD44, apoptosis and thymidylate synthase inhibition rate correlate with the efficacy of chemotherapy in colorectal cancer?
Colorectal Neoplasms
Does biomolecular characterization of stage II/III colorectal cancer have any prognostic value?
Colorectal Neoplasms
Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma.
Colorectal Neoplasms
DPYD, TYMS and MTHFR Genes Polymorphism Frequencies in a Series of Turkish Colorectal Cancer Patients.
Colorectal Neoplasms
Dynamic modulation of thymidylate synthase gene expression and fluorouracil sensitivity in human colorectal cancer cells.
Colorectal Neoplasms
E2F1/TS Immunophenotype and Survival of Patients with Colorectal Cancer Treated with 5FU-Based Adjuvant Therapy.
Colorectal Neoplasms
Effect of leucovorin on the antitumor efficacy of the 5-FU prodrug, tegafur-uracil, in human colorectal cancer xenografts with various expression levels of thymidylate synthase.
Colorectal Neoplasms
Effects of 5-fluorouracil derivative UFT on thymidylate synthetase and thymidine kinase in rat colorectal tumors.
Colorectal Neoplasms
Efficacy, tolerability and management of raltitrexed (Tomudex) monotherapy in patients with advanced colorectal cancer. a review of phase II/III trials.
Colorectal Neoplasms
EGF61A>G polymorphism as predictive marker of clinical outcome to first-line capecitabine and oxaliplatin in metastatic colorectal cancer.
Colorectal Neoplasms
Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy.
Colorectal Neoplasms
Enhanced DNA-directed effects of FdUMP[10] compared to 5FU.
Colorectal Neoplasms
ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy.
Colorectal Neoplasms
Exposure-response analysis of Raltitrexed assessing liver toxicity.
Colorectal Neoplasms
Expression and gene regulation network of TYMS and BCL2L1 in colorectal cancer based on data mining.
Colorectal Neoplasms
Expression level of thymidylate synthase is a good predictor of chemosensitivity to 5-fluorouracil in colorectal cancer.
Colorectal Neoplasms
Expression level of thymidylate synthase mRNA reflects 5-fluorouracil sensitivity with low dose and long duration in primary colorectal cancer.
Colorectal Neoplasms
Expression levels of thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase in patients with colorectal cancer.
Colorectal Neoplasms
Expression of astrocyte-elevated gene-1 indicates prognostic value of fluoropyrimidine-based adjuvant chemotherapy in resectable stage III colorectal cancer.
Colorectal Neoplasms
Expression of dihydropyrimidine dehydrogenase, orotate phosphoribosyl transferase and thymidylate synthase in patients with primary colorectal cancer, and associations with site of first metastasis.
Colorectal Neoplasms
Expression of dihydropyrimidine dehydrogenase, thymidylate synthase, p53 and p21 in metastatic liver tumor from colorectal cancer after 5-fluorouracil-based chemotherapy.
Colorectal Neoplasms
Expression of ERCC1 and TYMS in colorectal cancer patients and the predictive value of chemotherapy efficacy.
Colorectal Neoplasms
Expression of thymidylate synthase gene in human colorectal carcinomas by northern blotting and reflectance in-situ hybridization (rish) - correlation with the number of chromosome-18.
Colorectal Neoplasms
Expression of thymidylate synthase in liver and lung metastases of colorectal cancer and their matched primary tumours.
Colorectal Neoplasms
Failure of detection of the tyrosine to histidine substitution at the residue 33 of thymidylate synthase in human colorectal cancer. A preliminary study.
Colorectal Neoplasms
Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells.
Colorectal Neoplasms
Functional polymorphism of the thymidylate synthase gene in colorectal cancer accompanied by frequent loss of heterozygosity.
Colorectal Neoplasms
G>C SNP of thymidylate synthase with respect to colorectal cancer.
Colorectal Neoplasms
Gene expression of 5-fluorouracil metabolic enzymes in primary colorectal cancer and corresponding liver metastasis.
Colorectal Neoplasms
Gene expression of vascular endothelial growth factor a, thymidylate synthase, and tissue inhibitor of metalloproteinase 3 in prediction of response to bevacizumab treatment in colorectal cancer patients.
Colorectal Neoplasms
Genetic heterogeneity of variable number tandem repeats in thymidylate synthase gene in colorectal cancer patients.
Colorectal Neoplasms
Haematological and non-haematological toxicity after 5-fluorouracil and leucovorin in patients with advanced colorectal cancer is significantly associated with gender, increasing age and cycle number. Tomudex International Study Group.
Colorectal Neoplasms
Heterozygote deficiency in thymidylate synthase enhancer region polymorphism genotype distribution in Hungarian colorectal cancer patients.
Colorectal Neoplasms
High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies.
Colorectal Neoplasms
High thymidylate synthase expression is typical for sporadic MSI-H colorectal carcinoma.
Colorectal Neoplasms
Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma.
Colorectal Neoplasms
HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy.
Colorectal Neoplasms
Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.
Colorectal Neoplasms
Immunohistochemical analysis of thymidylate synthase, p16(INK4a), cyclin-dependent kinase 4 and cyclin D1 in colorectal cancers receiving preoperative chemotherapy: significance of p16(INK4a)-mediated cellular arrest as an indicator of chemosensitivity to 5-fluorouracil.
Colorectal Neoplasms
Immunohistochemical determination of p53 protein does not predict clinical response in advanced colorectal cancer with low thymidylate synthase expression receiving a bolus 5-fluorouracil-leucovorin combination.
Colorectal Neoplasms
Immunohistochemical evaluation of thymidylate synthase (TS) and p16INK4a in advanced colorectal cancer: implication of TS expression in 5-FU-based adjuvant chemotherapy.
Colorectal Neoplasms
Immunohistochemical expression of thymidylate synthase as a prognostic factor and as a chemotherapeutic efficacy index in patients with colorectal carcinoma.
Colorectal Neoplasms
Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy.
Colorectal Neoplasms
Immunohistochemically detected thymidylate synthase in colorectal cancer: an independent prognostic factor of survival.
Colorectal Neoplasms
Impact of SHMT1 polymorphism on the clinical outcome of patients with metastatic colorectal cancer treated with first-line FOLFIRI+bevacizumab.
Colorectal Neoplasms
Importance of thymidine phosphorylase expression in tumor stroma as a prognostic factor in patients with advanced colorectal carcinoma.
Colorectal Neoplasms
Improved Antitumor Activity of the Fluoropyrimidine Polymer CF10 in Preclinical Colorectal Cancer Models through Distinct Mechanistic and Pharmacologic Properties.
Colorectal Neoplasms
Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independent mechanisms.
Colorectal Neoplasms
Increased thymidylate synthase gene expression in liver metastases from colorectal carcinoma: implications for chemotherapeutic options and survival.
Colorectal Neoplasms
Individualization of therapy for colorectal cancer based on clinical and molecular parameters.
Colorectal Neoplasms
Influence of thymidylate synthase and p53 protein expression on clinical outcome in patients with colorectal cancer.
Colorectal Neoplasms
Influence of thymidylate synthase DNA polymorphisms and gender on the clinical evolution of patients with advanced colorectal cancer.
Colorectal Neoplasms
Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil.
Colorectal Neoplasms
Inhibition of NF-?B translocation by curcumin analogs induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer.
Colorectal Neoplasms
Inhibition of thymidylate synthase: biochemical pharmacology of drugs with activity in colorectal cancer.
Colorectal Neoplasms
Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer.
Colorectal Neoplasms
Inter-relationship between microsatellite instability, thymidylate synthase expression, and p53 status in colorectal cancer: implications for chemoresistance.
Colorectal Neoplasms
Intratumoral induction of thymidylate synthase mRNA by 5-FU in colorectal cancer patients: association with survival.
Colorectal Neoplasms
Intratumoural thymidylate synthase and dihydropyrimidine dehydrogenase activities are good predictors of 5-fluorouracil sensitivity in colorectal cancer.
Colorectal Neoplasms
Isolation and characterization of a thymidylate synthase-deficient human colon tumor cell line.
Colorectal Neoplasms
Lack of correlation between immunohistochemical expression of E2F-1, thymidylate synthase expression and clinical response to 5-fluorouracil in advanced colorectal cancer.
Colorectal Neoplasms
Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapy.
Colorectal Neoplasms
Leucovorin rescue from raltitrexed (tomudex)-induced antiproliferative effects: in vitro cell line and in vivo mouse studies.
Colorectal Neoplasms
Liver-only metastatic colorectal cancer patients and thymidylate synthase polymorphisms for predicting response to 5-fluorouracil-based chemotherapy.
Colorectal Neoplasms
Long noncoding RNA XIST is a prognostic factor in colorectal cancer and inhibits 5-fluorouracil-induced cell cytotoxicity through promoting thymidylate synthase expression.
Colorectal Neoplasms
Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors.
Colorectal Neoplasms
Melatonin-mediated downregulation of thymidylate synthase as a novel mechanism for overcoming 5-fluorouracil associated chemoresistance in colorectal cancer cells.
Colorectal Neoplasms
Metabolism, excretion and pharmacokinetics of a single dose of [14C]-raltitrexed in cancer patients.
Colorectal Neoplasms
Methylenetetrahydrofolate reductase C677T is not associated with expression of pyrimidine metabolic enzyme genes in colorectal cancer.
Colorectal Neoplasms
Metronomic S-1 dosing and thymidylate synthase silencing have synergistic antitumor efficacy in a colorectal cancer xenograft model.
Colorectal Neoplasms
MicroRNA-197 influences 5-fluorouracil resistance via thymidylate synthase in colorectal cancer.
Colorectal Neoplasms
MicroRNA-330 inhibited cell proliferation and enhanced chemosensitivity to 5-fluorouracil in colorectal cancer by directly targeting thymidylate synthase.
Colorectal Neoplasms
MicroRNA-375-3p enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal cancer.
Colorectal Neoplasms
Microsatellite instability and the association with plasma homocysteine and thymidylate synthase in colorectal cancer.
Colorectal Neoplasms
Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expression.
Colorectal Neoplasms
miR-203 enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal cancer.
Colorectal Neoplasms
Modified Irinotecan/5FU/Leucovorin therapy in advanced colorectal cancer and predicting therapeutic efficacy by expression of tumor-related enzymes.
Colorectal Neoplasms
Molecular analysis of the polymorphisms of thymidylate synthase on cell-free circulating DNA in blood of patients with advanced colorectal carcinoma.
Colorectal Neoplasms
Molecular basis of antifolate resistance.
Colorectal Neoplasms
mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma.
Colorectal Neoplasms
New agents for colon and breast cancer.
Colorectal Neoplasms
New antimetabolites in cancer chemotherapy and their clinical impact.
Colorectal Neoplasms
New approaches to the treatment of gastro-intestinal cancer.
Colorectal Neoplasms
New promising anticancer agents in development: what comes next?
Colorectal Neoplasms
New targets for pyrimidine antimetabolites in the treatment of solid tumours. 1: Thymidylate synthase.
Colorectal Neoplasms
Non-covalent interactions involving halogenated derivatives of capecitabine and thymidylate synthase: a computational approach.
Colorectal Neoplasms
Novel approaches in the treatment of non-small-cell lung cancer.
Colorectal Neoplasms
Novel therapeutic developments other than EGFR and VEGF inhibition in colorectal cancer.
Colorectal Neoplasms
Nuclear expression of thymidylate synthase in colorectal cancer cell lines and clinical samples.
Colorectal Neoplasms
Nuclear thymidylate synthase expression in sporadic colorectal cancer depends on the site of the tumor.
Colorectal Neoplasms
Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma.
Colorectal Neoplasms
Open label, multi-centre phase II study of raltitrexed ('Tomudex') in patients with inoperable squamous-cell carcinoma of head and neck.
Colorectal Neoplasms
Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer. Tomudex Colorectal Cancer Study Group.
Colorectal Neoplasms
Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen.
Colorectal Neoplasms
Overexpression of E2F-1 in lung and liver metastases of human colon cancer is associated with gene amplification.
Colorectal Neoplasms
Oxaliplatin and protracted venous infusion of 5-fluorouracil in patients with advanced or relapsed 5-fluorouracil pretreated colorectal cancer.
Colorectal Neoplasms
P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells.
Colorectal Neoplasms
p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival.
Colorectal Neoplasms
p53, DCC and thymidylate synthase as predictors of survival after resection of hepatic metastases from colorectal cancer.
Colorectal Neoplasms
p53, deleted in colorectal cancer gene, and thymidylate synthase as predictors of histopathologic response and survival in low, locally advanced rectal cancer treated with preoperative adjuvant therapy.
Colorectal Neoplasms
Pharmacogenetic tailoring of irinotecan-based first-line chemotherapy in metastatic colorectal cancer: results of a pilot study.
Colorectal Neoplasms
Pharmacogenomics of fluorouracil, irinotecan, and oxaliplatin in hepatic metastases of colorectal cancer: clinical implications.
Colorectal Neoplasms
Phase 2 study of treatment selection based on tumor thymidylate synthase expression in previously untreated patients with metastatic colorectal cancer: A trial of the ECOG-ACRIN Cancer Research Group (E4203).
Colorectal Neoplasms
Phase I trial of sequential administration of raltitrexed (Tomudex) and 5-iodo-2'-deoxyuridine (IdUrd).
Colorectal Neoplasms
Phase Ib study of poly-epitope peptide vaccination to thymidylate synthase (TSPP) and GOLFIG chemo-immunotherapy for treatment of metastatic colorectal cancer patients.
Colorectal Neoplasms
Phase II study of raltitrexed (Tomudex) in chemotherapy-pretreated patients with advanced colorectal cancer. Tomudex Cooperative Study Group.
Colorectal Neoplasms
Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase.
Colorectal Neoplasms
Phase II study of the thymidylate synthetase inhibitor CB3717 (N10-propargyl-5,8-dideazafolic acid) in colorectal cancer.
Colorectal Neoplasms
Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer.
Colorectal Neoplasms
Polymorphism in the thymidylate synthase promoter enhancer region is not an efficacious marker for tumor sensitivity to 5-fluorouracil-based oral adjuvant chemotherapy in colorectal cancer.
Colorectal Neoplasms
Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer.
Colorectal Neoplasms
Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients.
Colorectal Neoplasms
Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer.
Colorectal Neoplasms
Polymorphisms in the thymidylate synthase and dihydropyrimidine dehydrogenase genes predict response and toxicity to capecitabine-raltitrexed in colorectal cancer.
Colorectal Neoplasms
Polymorphisms in the thymidylate synthase gene and risk of colorectal cancer.
Colorectal Neoplasms
Polymorphisms in the thymidylate synthase gene predict response to 5-fluorouracil therapy in colorectal cancer.
Colorectal Neoplasms
Polymorphisms of folate metabolism-related genes and survival of patients with colorectal cancer in the Korean population.
Colorectal Neoplasms
Predicting 5-fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: three-gene expression model predicts clinical response.
Colorectal Neoplasms
Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO study.
Colorectal Neoplasms
Predictive diagnostics in colorectal cancer: impact of genetic polymorphisms on individual outcomes and treatment with fluoropyrimidine-based chemotherapy.
Colorectal Neoplasms
Predictive Potential of PD-L1, TYMS, and DCC Expressions in Treatment Outcome of Colorectal Carcinoma.
Colorectal Neoplasms
Predictive role of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer patients receiving adjuvant 5-fluorouracil.
Colorectal Neoplasms
Predictive value of expression of ERCC 1 and GST-p for 5-fluorouracil/oxaliplatin chemotherapy in advanced colorectal cancer.
Colorectal Neoplasms
Predictive value of thymidylate synthase expression in advanced colorectal cancer patients receiving fluoropyrimidine-based chemotherapy: evidence from 24 studies.
Colorectal Neoplasms
Predictive value of thymidylate synthase expression in resected metastases of colorectal cancer.
Colorectal Neoplasms
Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis.
Colorectal Neoplasms
Prognostic and Predictive role of Excision Repair Cross-complementation Group 1 and Thymidylate Synthase in Colorectal Carcinoma Patients Received FOLFOX Chemotherapy: An Immunohistochemical Study.
Colorectal Neoplasms
Prognostic and predictive value of the thymidylate synthase expression in patients with non-metastatic colorectal cancer.
Colorectal Neoplasms
Prognostic and predictive value of thymidylate synthase expression in primary colorectal cancer.
Colorectal Neoplasms
Prognostic impact of orotate phosphoribosyl transferase among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy.
Colorectal Neoplasms
Prognostic markers in early-stage colorectal cancer: significance of TYMS mRNA expression.
Colorectal Neoplasms
Prognostic role of thymidylate synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor, and proliferation markers in colorectal cancer.
Colorectal Neoplasms
Prognostic significance of numeric aberrations of genes for thymidylate synthase, thymidine phosphorylase and dihydrofolate reductase in colorectal cancer.
Colorectal Neoplasms
Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors.
Colorectal Neoplasms
Prognostic significance of thymidylate synthase expression in the adjuvant chemotherapy after resection for pulmonary metastases from colorectal cancer.
Colorectal Neoplasms
Prognostic significance of thymidylate synthase in patients with metastatic colorectal cancer who receive protracted venous infusions of 5-fluorouracil.
Colorectal Neoplasms
Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy.
Colorectal Neoplasms
Prognostic value of ERCC1, thymidylate synthase, and glutathione S-transferase pi for 5-FU/oxaliplatin chemotherapy in advanced colorectal cancer.
Colorectal Neoplasms
Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses.
Colorectal Neoplasms
Protective effects of an antiulcer agent, ecabet sodium on colorectal carcinogenesis in rodents.
Colorectal Neoplasms
Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin.
Colorectal Neoplasms
Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: preliminary report from an ongoing trial.
Colorectal Neoplasms
Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2.
Colorectal Neoplasms
Raltitrexed ('Tomudex') and radiotherapy can be combined as postoperative treatment for rectal cancer.
Colorectal Neoplasms
Raltitrexed (Tomudex).
Colorectal Neoplasms
Raltitrexed in the treatment of elderly patients with advanced colorectal cancer: an active and low toxicity regimen.
Colorectal Neoplasms
Raltitrexed increases tumorigenesis as a single agent yet exhibits anti-tumor synergy with 5-fluorouracil in ApcMin/+ mice.
Colorectal Neoplasms
Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer.
Colorectal Neoplasms
Real-time RT-PCR (TaqMan) of tumor mRNA to predict sensitivity of specimens to 5-fluorouracil.
Colorectal Neoplasms
Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method.
Colorectal Neoplasms
Relationship between thymidylate synthase (TS) genotype and TS expression: a tissue microarray analysis of colorectal cancers.
Colorectal Neoplasms
Relationship between TYMS and ERCC1 mRNA expression and in vitro chemosensitivity in colorectal cancer.
Colorectal Neoplasms
Relationship of polymorphism of the tandem repeat sequence in the thymidylate synthase gene and the survival of stage III colorectal cancer patients receiving adjuvant 5-flurouracil-based chemotherapy.
Colorectal Neoplasms
Relationships between promoter polymorphisms in the thymidylate synthase gene and mRNA levels in colorectal cancers.
Colorectal Neoplasms
Relationships between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase and cell proliferative activity and 5-fluorouracil sensitivity in colorectal carcinoma.
Colorectal Neoplasms
Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate.
Colorectal Neoplasms
Response prediction in metastasised colorectal cancer using intratumoural thymidylate synthase: Results of a randomised multicentre trial.
Colorectal Neoplasms
Retrospective study on thymidylate synthase as a predictor of outcome and sensitivity to adjuvant chemotherapy in patients with curatively resected colorectal cancer.
Colorectal Neoplasms
Role of topoisomerase I and thymidylate synthase expression in sporadic colorectal cancer: associations with clinicopathological and molecular features.
Colorectal Neoplasms
S-1 plus Raltitrexed for Refractory Metastatic Colorectal Cancer: A Phase II Trial.
Colorectal Neoplasms
Schedule-dependent interaction between raltitrexed and 5-fluorouracil in human colon cancer cell lines in vitro.
Colorectal Neoplasms
Schedule-dependent synergism and antagonism between raltitrexed ("Tomudex") and methotrexate in human colon cancer cell lines in vitro.
Colorectal Neoplasms
Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition.
Colorectal Neoplasms
Significance of Differential Expression of Thymidylate Synthase in Normal and Primary Tumor Tissues from Patients with Colorectal Cancer.
Colorectal Neoplasms
Single nucleotide polymorphism in the 5' tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients.
Colorectal Neoplasms
Structural analysis of cDNA encoding thymidylate synthase in hepatic metastases of human colorectal tumors.
Colorectal Neoplasms
Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.
Colorectal Neoplasms
Studying the predictive/prognostic role of thymidylate synthase genotypes in patients with colorectal cancer: Is one polymorphism enough?
Colorectal Neoplasms
Systemic inflammatory status predict the outcome of k-RAS WT metastatic colorectal cancer patients receiving the thymidylate synthase poly-epitope-peptide anticancer vaccine.
Colorectal Neoplasms
Tacalcitol increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating the thymidylate synthase.
Colorectal Neoplasms
Targeting thymidylate synthase in colorectal cancer: critical re-evaluation and emerging therapeutic role of raltitrexed.
Colorectal Neoplasms
The effect of surgically induced ischaemia on gene expression in a colorectal cancer xenograft model.
Colorectal Neoplasms
The efficacy of 5-fluorouracil in human colorectal cancer is not enhanced by thymidylate synthetase inhibition with CB3717 (N10-propargyl-5,8 dideazafolic acid).
Colorectal Neoplasms
The establishment of a large collaborative trial programme in the adjuvant treatment of colon cancer.
Colorectal Neoplasms
The Impact of Thymidylate Synthase and Methylenetetrahydrofolate Reductase Genotypes on Sensitivity to 5-Fluorouracil Treatment in Colorectal Cancer Cells.
Colorectal Neoplasms
The prognostic significance of thymidylate synthase and dihydropyrimidine dehydrogenase in colorectal cancer of 303 patients adjuvantly treated with 5-fluorouracil.
Colorectal Neoplasms
The relationship between intrinsic thymidylate synthase expression and sensitivity to THYMITAQ in human leukaemia and colorectal carcinoma cell lines.
Colorectal Neoplasms
The role of oxaliplatin in the treatment of advanced metastatic colorectal cancer: prospects and future directions.
Colorectal Neoplasms
The role of thymidylate synthase levels in the prognosis and the treatment of patients with colorectal cancer.
Colorectal Neoplasms
The use of thymidylate synthase inhibitors in the treatment of advanced colorectal cancer: current status.
Colorectal Neoplasms
Thymidine phosphorylase expression is associated with response to capecitabine plus irinotecan in patients with metastatic colorectal cancer.
Colorectal Neoplasms
Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors-correlation to tumor histopathology and clinical follow-up.
Colorectal Neoplasms
Thymidylate synthase (TS) protein expression as a prognostic factor in advanced colorectal cancer: a comparison with TS mRNA expression.
Colorectal Neoplasms
Thymidylate synthase and cyclin d1 protein expression in lymph node negative colorectal cancer: role as prognostic factors?
Colorectal Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5-fluorouracil to patients with colorectal cancer.
Colorectal Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil.
Colorectal Neoplasms
Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients.
Colorectal Neoplasms
Thymidylate synthase and microsatellite instability in colorectal cancer: Implications for disease free survival, treatment response and survival with metastases.
Colorectal Neoplasms
Thymidylate synthase and p53 expression in primary tumor do not predict chemotherapy outcome in metastatic colorectal carcinoma.
Colorectal Neoplasms
Thymidylate synthase and thymidine phosphorylase mRNA expression in primary lesions using laser capture microdissection is useful for prediction of the efficacy of FOLFOX treatment in colorectal cancer patients with liver metastasis.
Colorectal Neoplasms
Thymidylate synthase as a predictor of response.
Colorectal Neoplasms
Thymidylate synthase expression and genotype have no major impact on the clinical outcome of colorectal cancer patients treated with 5-fluorouracil.
Colorectal Neoplasms
Thymidylate synthase expression and p21(WAF1)/p53 phenotype of colon cancers identify patients who may benefit from 5-fluorouracil based therapy.
Colorectal Neoplasms
Thymidylate synthase expression and prognosis in colorectal cancer: a meta-analysis of colorectal cancer survival data.
Colorectal Neoplasms
Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis.
Colorectal Neoplasms
Thymidylate Synthase expression as a predictor of clinical response to fluoropyrimidine-based chemotherapy in advanced colorectal cancer.
Colorectal Neoplasms
Thymidylate synthase expression as a predictor of the prognosis of curatively resected colon carcinoma in patients registered in an adjuvant immunochemotherapy clinical trial.
Colorectal Neoplasms
Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed.
Colorectal Neoplasms
Thymidylate synthase expression in circulating tumor cells: A new tool to predict 5-fluorouracil resistance in metastatic colorectal cancer patients.
Colorectal Neoplasms
Thymidylate synthase expression in colorectal cancer: a prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy.
Colorectal Neoplasms
Thymidylate synthase expression in colorectal cancer: the never-ending story.
Colorectal Neoplasms
Thymidylate synthase expression in hepatic tumors is a predictor of survival and progression in patients with resectable metastatic colorectal cancer.
Colorectal Neoplasms
Thymidylate synthase expression in normal colonic mucosa: a predictive marker of toxicity in colorectal cancer patients receiving 5-fluorouracil-based adjuvant chemotherapy.
Colorectal Neoplasms
Thymidylate synthase expression in patients with colorectal carcinoma using a polyclonal thymidylate synthase antibody in comparison to the TS 106 monoclonal antibody.
Colorectal Neoplasms
Thymidylate synthase expression in primary colorectal cancer as a predictive marker for the response to 5-fluorouracil- and oxaliplatin-based preoperative chemotherapy for liver metastases.
Colorectal Neoplasms
Thymidylate synthase expression in primary colorectal tumours is correlated with its expression in metastases.
Colorectal Neoplasms
Thymidylate synthase expression in rectal cancer and proliferation, assessed by cyclin A and Ki-67 expression.
Colorectal Neoplasms
Thymidylate synthase expression levels: a prognostic and predictive role in advanced colorectal cancer.
Colorectal Neoplasms
Thymidylate synthase expression pattern is a prognostic factor in patients of colorectal cancer treated with 5-fluorouracil.
Colorectal Neoplasms
Thymidylate synthase expression pattern, expression level and single nucleotide polymorphism are predictors for disease-free survival in patients of colorectal cancer treated with 5-fluorouracil.
Colorectal Neoplasms
Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer.
Colorectal Neoplasms
Thymidylate synthase expression, p53, bcl-2, Ki-67 and p27 in colorectal cancer: relationships with tumor recurrence and survival.
Colorectal Neoplasms
Thymidylate synthase expression: an independent prognostic factor for local recurrence, distant metastasis, disease-free and overall survival in rectal cancer.
Colorectal Neoplasms
Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: enzyme activity and inhibition by 5-fluoro-2'-deoxy-uridine-5'-monophosphate.
Colorectal Neoplasms
Thymidylate synthase gene expression in primary colorectal cancer and metastatic sites.
Colorectal Neoplasms
Thymidylate Synthase Gene Expression in Primary Colorectal Cancer and Metastatic Sites.
Colorectal Neoplasms
Thymidylate Synthase Gene Polymorphism and Survival of Colorectal Cancer Patients Receiving Adjuvant 5-Fluorouracil.
Colorectal Neoplasms
Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer.
Colorectal Neoplasms
Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy.
Colorectal Neoplasms
Thymidylate synthase gene promoter polymorphisms are associated with TSmRNA expressions but not with microsatellite instability in colorectal cancer.
Colorectal Neoplasms
Thymidylate synthase gene variants as predictors of clinical response and toxicity to fluoropyrimidine-based chemotherapy for colorectal cancer.
Colorectal Neoplasms
Thymidylate synthase genetic polymorphisms and colorectal cancer risk: A meta-analysis.
Colorectal Neoplasms
Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines.
Colorectal Neoplasms
Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors.
Colorectal Neoplasms
Thymidylate synthase inhibitors in colorectal cancer.
Colorectal Neoplasms
Thymidylate synthase level and DNA-ploidy pattern as possible prognostic factors in human colorectal cancer: a preliminary study.
Colorectal Neoplasms
Thymidylate synthase levels in tumor biopsies from patients with colorectal cancer.
Colorectal Neoplasms
Thymidylate synthase pharmacogenetics in colorectal cancer.
Colorectal Neoplasms
Thymidylate Synthase Pharmacogenetics in Colorectal Cancer.
Colorectal Neoplasms
Thymidylate synthase polymorphism and microsatellite instability: association in colorectal cancer.
Colorectal Neoplasms
Thymidylate synthase polymorphism and survival of colorectal cancer patients treated with 5-fluorouracil.
Colorectal Neoplasms
Thymidylate synthase polymorphism in sporadic colorectal and gastric cancer in Tunisian population: a predictive role in 5-fluorouracil based chemotherapy treatment.
Colorectal Neoplasms
Thymidylate synthase protein expression in advanced colon cancer: correlation with the site of metastasis and the clinical response to leucovorin-modulated bolus 5-fluorouracil.
Colorectal Neoplasms
Thymidylate synthase protein expression in colorectal cancer metastases predicts for clinical outcome to leucovorin-modulated bolus or infusional 5-fluorouracil but not methotrexate-modulated bolus 5-fluorouracil.
Colorectal Neoplasms
Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil.
Colorectal Neoplasms
Thymidylate synthase protein expression in primary colorectal cancer: lack of correlation with outcome and response to fluorouracil in metastatic disease sites.
Colorectal Neoplasms
Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients.
Colorectal Neoplasms
Thymidylate Synthase, Thymidine Phosphorylase, VEGF and p53 Protein Expression in Primary Colorectal Cancer for Predicting Response to 5-fluorouracil-based Chemotherapy.
Colorectal Neoplasms
Thymidylate synthase, topoisomerase-1 and microsatellite instability: relationship with outcome in mucinous colorectal cancer treated with fluorouracil.
Colorectal Neoplasms
Thymidylate synthase: a target for combination therapy and determinant of chemotherapeutic response in colorectal cancer.
Colorectal Neoplasms
Thymidylate synthetase mRNA levels are increased in liver metastases of colorectal cancer patients resistant to fluoropyrimidine-based chemotherapy.
Colorectal Neoplasms
Topoisomerase I but not thymidylate synthase is associated with improved outcome in patients with resected colorectal cancer treated with irinotecan containing adjuvant chemotherapy.
Colorectal Neoplasms
Topoisomerase-I, thymidylate synthase primary tumour expression and clinical efficacy of 5-FU/CPT-11 chemotherapy in advanced colorectal cancer patients.
Colorectal Neoplasms
Transcription factor-binding sites in the thymidylate synthase gene: predictors of outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin?
Colorectal Neoplasms
Transgenic expression of human thymidylate synthase accelerates the development of hyperplasia and tumors in the endocrine pancreas.
Colorectal Neoplasms
TS and ERCC-1 mRNA expressions and clinical outcome in patients with metastatic colon cancer in CONFIRM-1 and -2 clinical trials.
Colorectal Neoplasms
Tumor thymidylate synthase 1494del6 genotype as a prognostic factor in colorectal cancer patients receiving fluorouracil-based adjuvant treatment.
Colorectal Neoplasms
TYMS serves as a prognostic indicator to predict the lymph node metastasis in Chinese patients with colorectal cancer.
Colorectal Neoplasms
UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy.
Colorectal Neoplasms
UGT1A1 predicts outcome in colorectal cancer treated with irinotecan and fluorouracil.
Colorectal Neoplasms
Upregulation of enzymes metabolizing 5-fluorouracil in colorectal cancer.
Colorectal Neoplasms
Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy.
Colorectal Neoplasms
Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer.
Colorectal Neoplasms
Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients.
Colorectal Neoplasms
Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase.
Colorectal Neoplasms
ZD-9331 AstraZeneca.
Colorectal Neoplasms
ZD1694 (Tomudex): a new thymidylate synthase inhibitor with activity in colorectal cancer.
Colorectal Neoplasms
ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. Tomudex Colorectal Study Group.
Colorectal Neoplasms
[A late phase II study of raltitrexed (ZD 1694) in chemotherapy-naive patients with advanced colorectal cancer]
Colorectal Neoplasms
[Activities of thymidylate synthase and dihydropyrimidine dehydrogenase in patients with colorectal cancer]
Colorectal Neoplasms
[Changes of the number of FdUMP binding sites of thymidylate synthase and folate pools in human colorectal carcinomas following the administration of tegafur and uracil: preliminary report]
Colorectal Neoplasms
[Correlation between 5-fluorouracil (5-FU) sensitivity as measured by collagen gel droplet embedded culture drug sensitivity test (CD-DST) and expression of orotate phosphoribosyl transferase (OPRT), thymidylate synthase (TS), and dihydropyrimidine dehydrogenase (DPD) in colorectal cancer]
Colorectal Neoplasms
[Correlation between clinical pathologic factors and enzymatic activity of orotate Phosphoribosyl transferase (OPRT), Dihydropyrimidine dehydrogenase (DPD) and Thymidylate synthase (TS) in colorectal cancer]
Colorectal Neoplasms
[Correlation between clinical pathophysiologic factors and expression of orotate phosphoribosyl transferase (OPRT), thymidylate synthase (TS), and dihydropyrimidine dehydrogenase (DPD) in colorectal cancer]
Colorectal Neoplasms
[Effects of RNA interference and nolatrexed on thymidylate synthase expression and cell proliferation of human colorectal carcinoma LOVO cells].
Colorectal Neoplasms
[Expression of mRNA levels of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase of colorectal cancer--relationships among mRNA levels in association with response to 5-FU based treatment]
Colorectal Neoplasms
[Expression of mRNA levels of thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase and orotate phosphoribosyltransferase in diffusely infiltrating colorectal cancer]
Colorectal Neoplasms
[Expression of thymidylate synthase gene and recurrence of colorectal carcinoma: their relation and clinical significance]
Colorectal Neoplasms
[Neo-adjuvant chemotherapy with tegafur suppository for rectal cancer--evaluation of the antitumor effects, tissue levels of 5-FU and inhibition of thymidylate synthase. Tochigi Colorectal Cancer Study Group]
Colorectal Neoplasms
[Potentiation of thymidylate synthetase (TS) inhibition by combined administration of HCFU and dipyridamole: preliminary report. Kinki Cooperative Study Group of Chemotherapy for Colorectal Carcinoma]
Colorectal Neoplasms
[Prediction of the efficacy of modified FOLFOX6 therapy according to the mRNA levels of thymidylate synthase (TS), excision repair cross-complementing-1 and -2( ERCC-1 and ERCC-2) and methylenetetrahydrofolate dehydrogenase( MTHFD) in the primary lesion of colorectal cancer].
Colorectal Neoplasms
[Prognostic value of thymidylate synthase, topoisomerase-1 and Ki-67 in advanced colorectal cancer patients on irinotecan and fluorouracil treatment]
Colorectal Neoplasms
[Pyrimidine nucleoside phosphorylase activity, 5-fluorouracil concentration and thymidylate synthase inhibition rate in colorectal cancer after oral administration of 5'-doxifluridine]
Colorectal Neoplasms
[Relationship between expression of thymidylate synthase and colorectal carcinoma]
Colorectal Neoplasms
[Results of prophylactic hepatic arterial chemotherapy for liver metastases of Dukes C colorectal cancer--correlation with tumoral expression of dihydropyrimidine dehydrogenase, thymidylate synthase, p53, or orotate phosphoribosyl transferase]
Colorectal Neoplasms
[Some problems of TS measurement after administration of fluoropyrimidines in colorectal cancer. Kinki Cooperative Study Group of Chemotherapy for Colorectal Carcinoma]
Colorectal Neoplasms
[The expression of thymidylate synthase (TS) and excision repair complementing-1 (ERCC-1) protein in patients with unresectable colorectal cancer treated with mFOLFOX6 therapy].
Colorectal Neoplasms
[The Relationship between the efficacy of mFOLFOX6 treatment and the expression of TS, DPD, TP, and ERCC-1 in unresectable colorectal cancer].
Colorectal Neoplasms
[Thymidylate synthase activity after preoperative administration of 5-FU in patients with gastric or colorectal cancer]
Colorectal Neoplasms
[Thymidylate synthase and dihydropyrimidine dehydrogenase activity in a metastatic liver tumor from colorectal cancer]
Colorectal Neoplasms
[Thymidylate synthase and dihydropyrimidine dehydrogenase gene expressions in colorectal cancer using the Danenberg tumor profile method]
Communicable Diseases
Antifolate agents: a patent review (2010 - 2013).
Communicable Diseases
Site-directed ligand discovery.
Coronary Artery Disease
Interactions of 5'-UTR thymidylate synthase polymorphism with 677C? T methylene tetrahydrofolate reductase and 66A? G methyltetrahydrofolate homocysteine methyl-transferase reductase polymorphisms determine susceptibility to coronary artery disease.
Crohn Disease
A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease.
Cytomegalovirus Infections
Human cytomegalovirus infection induces cellular thymidylate synthase gene expression in quiescent fibroblasts.
dihydrofolate reductase deficiency
Construction of a dihydrofolate reductase-deficient mutant of Escherichia coli by gene replacement.
dihydropyrimidinase deficiency
A simple and fast LC-MS/MS method with a very high sensitivity for the measurement of raltitrexed in human plasma.
dihydropyrimidinase deficiency
Exposure-response analysis of Raltitrexed assessing liver toxicity.
Dihydropyrimidine Dehydrogenase Deficiency
A simple and fast LC-MS/MS method with a very high sensitivity for the measurement of raltitrexed in human plasma.
Dihydropyrimidine Dehydrogenase Deficiency
Exposure-response analysis of Raltitrexed assessing liver toxicity.
Drug-Related Side Effects and Adverse Reactions
Thymidylate synthase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) polymorphisms in the Korean population for prediction of 5-fluorouracil-associated toxicity.
Drug-Related Side Effects and Adverse Reactions
Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients.
Elephantiasis, Filarial
An insight into the discovery of potent antifilarial leads against lymphatic filariasis.
Endometrial Neoplasms
Association of thymidylate synthase gene with endometrial cancer risk in a Chinese population.
Esophageal Neoplasms
Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance.
Esophageal Neoplasms
Is there a correlation between molecular markers and response to neoadjuvant chemoradiotherapy in locally advanced squamous cell esophageal cancer?
Esophageal Neoplasms
Roles of thymidylate synthase and dihydropyrimidine dehydrogenase expression in blood as predictors of response to multimodal therapy in esophageal cancer.
Esophageal Neoplasms
Thymidylate synthetase and dihydropyrimidine dehydrogenase mRNA levels in esophageal cancer.
Esophageal Squamous Cell Carcinoma
Association of the thymidylate synthase polymorphisms with esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma.
Esophageal Squamous Cell Carcinoma
Expression of ERCC1, TYMS, TUBB3, RRM1 and TOP2A in patients with esophageal squamous cell carcinoma: A hierarchical clustering analysis.
Esophageal Squamous Cell Carcinoma
Expression of thymidylate synthase and glutathione-s-transferase pi in patients with esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Genetic polymorphisms in folate- metabolizing enzymes and risk of gastroesophageal cancers: a potential nutrient-gene interaction in cancer development.
Esophageal Squamous Cell Carcinoma
Thymidylate synthetase and dihydropyrimidine dehydrogenase mRNA levels in esophageal cancer.
Esophageal Squamous Cell Carcinoma
[ERCC1 and TS expression in chemoradiotherapy treated esophageal squamous cell carcinoma].
Esophageal Squamous Cell Carcinoma
[Polymorphisms of thymidylate synthase gene and correlation of its protein expression to lymph node metastasis of esophageal squamous cell carcinoma]
Esophageal Stenosis
A unique case of a patient with rectal cancer who developed benign esophageal stenosis after localized rectal radiation and systemic chemotherapy.
Fibrosarcoma
Elevation of radiolabelled thymidine uptake in RIF-1 fibrosarcoma and HT29 colon adenocarcinoma cells after treatment with thymidylate synthase inhibitors.
Fibrosarcoma
Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase.
Fibrosarcoma
Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. II. Synthesis and antitumor activity of N5-substituted glutamine analogs.
Fowlpox
Establishment and characterization of a thymidine kinase deficient avian fibroblast cell line derived from a Japanese quail cell line, QT35.
Fragile X Syndrome
Thymidylate metabolism in fragile X syndrome cells.
Gallbladder Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase expressions in gallbladder cancer.
Gastrointestinal Neoplasms
Correlation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2'-deoxyuridine.
Gastrointestinal Neoplasms
Dependence of 5-fluorouracil-mediated radiosensitization on DNA-directed effects.
Gastrointestinal Neoplasms
Dihydropyrimidine dehydrogenase, multidrug resistance-associated protein, and thymidylate synthase gene expression levels can predict 5-fluorouracil resistance in human gastrointestinal cancer cells.
Gastrointestinal Neoplasms
Discrepancies between the gene expression, protein expression, and enzymatic activity of thymidylate synthase and dihydropyrimidine dehydrogenase in human gastrointestinal cancers and adjacent normal mucosa.
Gastrointestinal Neoplasms
Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer.
Gastrointestinal Neoplasms
Expression and prognostic significance of thymidylate synthase (TS) in pancreatic head and periampullary cancer.
Gastrointestinal Neoplasms
Impact of the expression of thymidylate synthase and dihydropyrimidine dehydrogenase genes on survival in stage II/III gastric cancer.
Gastrointestinal Neoplasms
Intratumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase in non-small cell lung cancer patients treated with 5-FU-based chemotherapy.
Gastrointestinal Neoplasms
Molecular markers predictive of response to chemotherapy in gastrointestinal tumors.
Gastrointestinal Neoplasms
Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers.
Gastrointestinal Neoplasms
Polymorphism of thymidylate synthase gene and chemosensitivity of 5-fluorouracil regimen in metastatic gastrointestinal cancer.
Gastrointestinal Neoplasms
Prognostic implications of thymidylate synthase gene polymorphisms in patients with advanced small bowel adenocarcinoma treated with first-line fluoropyrimidine-based chemotherapy.
Gastrointestinal Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in breast cancer predicts 5-FU sensitivity by a histocultural drug sensitivity test.
Gastrointestinal Neoplasms
Thymidylate synthase expression and prognosis of patients with gastrointestinal cancers receiving adjuvant chemotherapy: a review.
Glioblastoma
Auger electron therapy of glioblastoma using [125I]5-iodo-2'-deoxyuridine and concomitant chemotherapy - Evaluation of a potential treatment strategy.
Glioblastoma
Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM).
Glioblastoma
MALAT1 is a prognostic factor in glioblastoma multiforme and induces chemoresistance to temozolomide through suppressing miR-203 and promoting thymidylate synthase expression.
Glioma
5-Fluorocytosine-mediated apoptosis and DNA damage in glioma cells engineered to express cytosine deaminase and their enhancement with interferon.
Glioma
DHFR/TYMS are positive regulators of glioma cell growth and modulate chemo-sensitivity to temozolomide.
Glioma
Expression of TYMS in lymph node metastasis from low-grade glioma.
Graft vs Host Disease
Methylenetetrahydrofolate reductase and thymidylate synthase genotypes and risk of acute graft-versus-host disease following hematopoietic cell transplantation for chronic myelogenous leukemia.
Head and Neck Neoplasms
A multifactorial approach including tumoural epidermal growth factor receptor, p53, thymidylate synthase and dihydropyrimidine dehydrogenase to predict treatment outcome in head and neck cancer patients receiving 5-fluorouracil.
Head and Neck Neoplasms
Distribution of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase.
Head and Neck Neoplasms
Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma.
Head and Neck Neoplasms
Etodolac Improves 5-FU Sensitivity of Head and Neck Cancer Cells through Inhibition of Thymidylate Synthase.
Head and Neck Neoplasms
Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck.
Head and Neck Neoplasms
Prognostic value of p53, glutathione S-transferase pi, and thymidylate synthase for neoadjuvant cisplatin-based chemotherapy in head and neck cancer.
Head and Neck Neoplasms
Thymidylate synthase as a target for growth inhibition in methotrexate-sensitive and -resistant human head and neck cancer and leukemia cell lines.
Head and Neck Neoplasms
Thymidylate synthase expression and response to neoadjuvant chemotherapy in patients with advanced head and neck cancer.
Head and Neck Neoplasms
[Thymidylate synthase gene promoter polymorphism in advanced head and neck cancer treated by radio- and 5-fluorouracil chemotherapy.]
Hemangiosarcoma
Expression of thymidylate synthase (TS) and its prognostic significance in patients with cutaneous angiosarcoma.
Hematologic Neoplasms
Thymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis.
Herpes Simplex
Antiviral activity of 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl-5-iodocytosine against human cytomegalovirus in human skin fibroblasts.
Herpes Simplex
Effects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1.
Herpes Simplex
Enzyme prodrug gene therapy: synergistic use of the herpes simplex virus-cellular thymidine kinase/ganciclovir system and thymidylate synthase inhibitors for the treatment of colon cancer.
Herpes Simplex
Establishment of mutant FM3A murine mammary carcinoma cell strains transformed with the herpes simplex virus type 1 thymidine kinase gene.
Herpes Simplex
Nucleosides. 150. Synthesis and some biological properties of 5-monofluoromethyl, 5-difluoromethyl, and 5-trifluoromethyl derivatives of 2'-deoxyuridine and 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyluracil.
Herpes Simplex
Potent activity of 5-fluoro-2'-deoxyuridine and related compounds against thymidine kinase-deficient (TK-) herpes simplex virus: targeted at thymidylate synthase.
Herpes Simplex
Roles of thymidylate synthetase activity in herpes simplex virus-infected HeLa cells.
Herpes Simplex
The A+T-rich genome of Herpesvirus saimiri contains a highly conserved gene for thymidylate synthase.
Herpes Simplex
The cytostatic activity of 5-(1-azidovinyl)-2'-deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene-transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (lambda = 254 nm) exposure.
Herpes Simplex
Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
Herpes Zoster
Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine.
Hyperthyroidism
Effect of altered thyroid status on lysosomal enzymes and thymidylate synthetase activity in tumors and livers of host animals.
Hypothyroidism
Correlation of DNA accumulation rate with thymidylate synthetase activity in developing rat cerebellum: effect of hypothyroidism.
Hypothyroidism
Effect of altered thyroid status on lysosomal enzymes and thymidylate synthetase activity in tumors and livers of host animals.
Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri.
Infections
Acquisition of thymidylate synthetase activity by a thymine-requiring mutant of Bacillus subtilis following infection by the temperate phage phi 3.
Infections
Bacteriophage phi W-14-infected Pseudomonas acidovorans synthesizes hydroxymethyldeoxyuridine triphosphate.
Infections
Effects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1.
Infections
Human cytomegalovirus infection induces cellular thymidylate synthase gene expression in quiescent fibroblasts.
Infections
Human immunodeficiency virus 1 (HIV-1) virion infectivity factor (Vif) is part of reverse transcription complexes and acts as an accessory factor for reverse transcription.
Infections
Identification of microRNAs with heat stress responsive and immune properties in Marsupenaeus japonicus based on next-generation sequencing and bioinformatics analysis: Essential regulators in the heat stress-host interactions.
Infections
Inactivation of the Thymidylate Synthase thyA in Non-typeable Haemophilus influenzae Modulates Antibiotic Resistance and Has a Strong Impact on Its Interplay with the Host Airways.
Infections
Murine cytomegalovirus stimulates cellular thymidylate synthase gene expression in quiescent cells and requires the enzyme for replication.
Infections
Replication of thymidine kinase deficient herpes simplex virus type 1 in neuronal cell culture: infection of the PC 12 cell.
Infections
Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.
Infections
The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.
Infections
Transcriptomic and Metabolomics Profiling of Phage-Host Interactions between Phage PaP1 and Pseudomonas aeruginosa.
Ischemic Stroke
The 3'-UTR Polymorphisms in the Thymidylate Synthase (TS) Gene Associated with the Risk of Ischemic Stroke and Silent Brain Infarction.
Leiomyoma
PTEN, tau-AP-3, thymidylate synthase immunohistochemistry scoring expression in patients with uterine leiomyomas, uterine smooth muscle tumors of uncertain malignancy potential and uterine leiomyosarcomas.
Leiomyosarcoma
PTEN, tau-AP-3, thymidylate synthase immunohistochemistry scoring expression in patients with uterine leiomyomas, uterine smooth muscle tumors of uncertain malignancy potential and uterine leiomyosarcomas.
Leishmaniasis
Probing the structure of Leishmania major DHFR TS and structure based virtual screening of peptide library for the identification of anti-leishmanial leads.
Leukemia
123I-ITdU-mediated nanoirradiation of DNA efficiently induces cell kill in HL60 leukemia cells and in doxorubicin-, beta-, or gamma-radiation-resistant cell lines.
Leukemia
A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803.
Leukemia
Acyclic analogues of 5-fluoro-dUMP and 5-fluoro-2'-deoxyuridine: synthesis and inhibition of thymidylate synthase and tumour cell growth.
Leukemia
Amplification of the thymidylate synthase gene in an N10-propargyl-5,8-dideazafolic-acid-resistant human leukemia, MOLT-3 cell line developed in pteroylglutamic acid, but not in leucovorin.
Leukemia
Association of Thymidylate Synthase 5'-UTR 28bp Tandem Repeat and Serine Hydroxymethyltransfarase C1420T Polymorphisms with Susceptibility to Acute Leukemia.
Leukemia
beta-Carboline-benzoquinolizidine alkaloid deoxytubulosine inhibits thymidylate synthase activity in leukemic leukocytes from patients with chronic myeloblastic leukemia and acute lymphoblastic leukemia.
Leukemia
Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
Leukemia
Biological activity and intracellular metabolism of ZD1694 in human leukemia cell lines with different resistance mechanisms to antifolate drugs.
Leukemia
Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells.
Leukemia
Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.
Leukemia
Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
Leukemia
Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts.
Leukemia
Comparison of the inhibitory effects of hydroxyurea, 5-fluorodeoxyuridine, 3,4-dihydroxybenzylamine, and methotrexate on human squamous cell carcinoma.
Leukemia
Differential methotrexate resistance in childhood T- versus common/preB-acute lymphoblastic leukemia can be measured by an in situ thymidylate synthase inhibition assay, but not by the MTT assay.
Leukemia
Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells.
Leukemia
Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma.
Leukemia
Effect of Simultaneous Inhibition of Protein Kinase CK2 and Thymidylate Synthase in Leukemia and Breast Cancer Cells.
Leukemia
Effects of methotrexate on folates in Krebs ascites and L1210 murine leukemia cells.
Leukemia
Effects of UFT (mixed compound of tegafur and uracil) on cell kinetics and inhibition of thymidylate synthase in L1210 ascites tumor.
Leukemia
Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line.
Leukemia
Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells.
Leukemia
Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs.
Leukemia
Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.
Leukemia
Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin.
Leukemia
Inhibitory action of 10-deazaaminopterins and their polyglutamates on human thymidylate synthase.
Leukemia
Interconversion of tetrahydrofolate cofactors to dihydrofolate induced by trimetrexate after suppression of thymidylate synthase by fluorodeoxyuridine in L1210 leukemia cells.
Leukemia
Levels of thymidylate synthetase during normal culture growth of L1210 cells.
Leukemia
Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia.
Leukemia
Molecular characterization of human acute leukemia cell line resistant to ZD9331, a non-polyglutamatable thymidylate synthase inhibitor.
Leukemia
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Leukemia
Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors.
Leukemia
Multiple resistance mechanisms in acute nonlymphoblastic leukemia (ANLL).
Leukemia
N10-propargyl-5,8-dideazafolic acid (CB3717): inhibitory effects on human leukemia cell lines resistant to methotrexate or trimetrexate.
Leukemia
Polymorphisms involved in folate metabolism pathways and the risk of the development of childhood acute leukemia.
Leukemia
Polymorphisms of 5,10-methylenetetrahydrofolate reductase and thymidylate synthase, dietary folate intake, and the risk of leukemia in adults.
Leukemia
Raltitrexed, a novel folate-based thymidylate synthase inhibitor, for the treatment of acute leukemia: is this drug active against acute myelogenous leukemia?
Leukemia
Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro.
Leukemia
Rate and extent of interconversion of tetrahydrofolate cofactors to dihydrofolate after cessation of dihydrofolate reductase activity in stationary versus log phase L1210 leukemia cells.
Leukemia
Regulation of thymidylate synthetase in mouse leukemia cells (L1210).
Leukemia
Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
Leukemia
Studies with tetrahydrohomofolate and thymidylate synthetase from amethopterin-resistant mouse leukemia cells.
Leukemia
Synergistic effect of 5-fluorodeoxyuridine and quinazoline antifolates on murine leukemia self-cultured in vitro.
Leukemia
The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia.
Leukemia
Thymidylate synthase as a target for growth inhibition in methotrexate-sensitive and -resistant human head and neck cancer and leukemia cell lines.
Leukemia
Thymidylate synthase in childhood acute non-lymphoblastic leukemia.
Leukemia
Thymidylate synthase inhibition in cells with arrested DNA synthesis is not due to an allosteric interaction in the replitase complex.
Leukemia
Thymidylate synthetase and serine transhydroxymethylase activities in preleukemic disorders of erythropoiesis and acute leukemia.
Leukemia
Thymidylate synthetase of in vitro chemically and virally transformed rat cells.
Leukemia
[Polymorphisms of thymidylate synthase gene detected by RT-PCR-denaturing gradient gel electrophoresis in children with acute leukemia.]
Leukemia L1210
10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism.
Leukemia L1210
Acyclic analogues of 5-fluoro-dUMP and 5-fluoro-2'-deoxyuridine: synthesis and inhibition of thymidylate synthase and tumour cell growth.
Leukemia L1210
Altered mouse leukemia L1210 thymidylate synthase, associated with cell resistance to 5-fluoro-dUrd, is not mutated but rather reflects posttranslational modification.
Leukemia L1210
Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds.
Leukemia L1210
Levels of thymidylate synthetase during normal culture growth of L1210 cells.
Leukemia L1210
Linear free energy relationship studies of enzyme active site binding: thymidylate synthase.
Leukemia L1210
Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro.
Leukemia L1210
Strategies for the measurement of the inhibitory effects of thymidine analogs on the activity of thymidylate synthase in intact murine leukemia L1210 cells.
Leukemia L1210
Synthesis and biological activity of N(alpha)-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid.
Leukemia L1210
Synthesis and biological activity of novel folic acid analogues: pteroyl-S-alkylhomocysteine sulfoximines.
Leukemia L1210
Synthesis of 5-selenium-substituted uracil derivatives. Inhibition of thymidylate synthetase by 5-hydroseleno-2'-deoxyuridylate.
Leukemia L1210
Thymidylate synthetase as target enzyme for the inhibitory activity of 5-substituted 2'-deoxyuridines on mouse leukemia L1210 cell growth.
Leukemia, Lymphoid
Antitumor agents. XXXIV: Mechanism of action of bruceoside A and brusatol on nucleic acid metabolism of P-388 lymphocytic leukemia cells.
Leukemia, Lymphoid
Cell cycle effects of antifolate antimetabolites: implications for cytotoxicity and cytostasis.
Leukemia, Lymphoid
Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Binding of N5,N10-methylene tetrahydrofolate and the inhibition of thymidylate synthesis by a folate-binding protein.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Methylenetetrahydrofolate reductase and thymidylate synthase genotypes and risk of acute graft-versus-host disease following hematopoietic cell transplantation for chronic myelogenous leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Thymidylate synthase activity in leukocytes from patients with chronic myelocytic leukemia and acute lymphocytic leukemia and its inhibition by phenanthroindolizidine alkaloids pergularinine and tylophorinidine.
Leukemia, Myeloid
Human thymidylate synthetase derived from blast cells of patients with acture myelocytic leukemia. Purification and chracterization.
Leukemia, Myeloid, Acute
Human thymidylate synthetase derived from blast cells of patients with acture myelocytic leukemia. Purification and chracterization.
Leukemia, Myeloid, Acute
Inhibitory action of 10-deazaaminopterins and their polyglutamates on human thymidylate synthase.
Leukemia, Myeloid, Acute
Mechanisms of resistance to methotrexate in childhood acute lymphoblastic leukemia: circumvention of thymidylate synthase inhibition.
Leukemia, Myeloid, Acute
Multiple resistance mechanisms in acute nonlymphoblastic leukemia (ANLL).
Leukemia, Myeloid, Acute
Thymidylate synthase in childhood acute non-lymphoblastic leukemia.
Leukemia, Myeloid, Acute
Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway.
Leukemia, Promyelocytic, Acute
Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma.
Leukemia, T-Cell
Cytotoxicity of trimetrexate against antifolate-resistant human T-cell leukemia cell lines developed in oxidized or reduced folate.
Leukemia, T-Cell
Mode of action of methotrexate-albumin in a human T-cell leukemia line and activity against an MTX-resistant clone.
Leukopenia
Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival.
Leukopenia
Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group.
Lipodystrophy
Association of thymidylate synthase gene polymorphisms with Stavudine triphosphate intracellular levels and lipodystrophy.
Lipodystrophy
Association of Thymidylate Synthase Polymorphisms with Acute Pancreatitis and/or Peripheral Neuropathy in HIV-Infected Patients on Stavudine-Based Therapy.
Liposarcoma
Identification of TYMS as a promoting factor of retroperitoneal liposarcoma progression: Bioinformatics analysis and biological evidence.
Liver Neoplasms
Folate metabolism-related gene polymorphisms and susceptibility to primary liver cancer in North China.
Liver Neoplasms
[Clinical significance of epidermal growth factor receptor and thymidylate synthase expression in primary liver cancer].
Liver Neoplasms
[Pharmacokinetic study of tegafur in the hepatic tissue obtained from the patients with liver cancer]
Liver Neoplasms, Experimental
Increased thymidylate synthetase activity in 5-fluorodeoxyuridine-resistant Novikoff hepatoma cells.
Liver Neoplasms, Experimental
Metabolism of 5-fluorouracil in sensitive and resistant Novikoff hepatoma cells.
Liver Neoplasms, Experimental
Thymidylate synthetase activity in the Novikoff hepatoma.
Lung Neoplasms
Antimetabolites and cancer: emerging data with a focus on antifolates.
Lung Neoplasms
Assessment of thymidylate synthase expression in biopsy specimens and corresponding resection specimens of non-small-cell lung cancer.
Lung Neoplasms
Association between EML4-ALK fusion gene and thymidylate synthase mRNA expression in non-small cell lung cancer tissues.
Lung Neoplasms
Association between expression of thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase and efficacy of pemetrexed in advanced non-small cell lung cancer.
Lung Neoplasms
Association between TYMS Expression and Efficacy of Pemetrexed-Based Chemotherapy in Advanced Non-Small Cell Lung Cancer: A Meta-Analysis.
Lung Neoplasms
Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC.
Lung Neoplasms
Astaxanthin enhances pemetrexed-induced cytotoxicity by downregulation of thymidylate synthase expression in human lung cancer cells.
Lung Neoplasms
Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression.
Lung Neoplasms
Biochemical and pharmacologic rationale for high-dose methotrexate.
Lung Neoplasms
Case-control analysis of thymidylate synthase polymorphisms and risk of lung cancer.
Lung Neoplasms
Chemotherapy followed by surgery on the basis of biomarker examination for patients with advanced non-small cell lung cancer.
Lung Neoplasms
Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer.
Lung Neoplasms
Correlation of Expression Levels of Copper Transporter 1 and Thymidylate Synthase with Treatment Outcomes in Patients with Advanced Non-small Cell Lung Cancer Treated with S-1/Carboplatin Doublet Chemotherapy
Lung Neoplasms
Deciphering Clinicoradiologic Phenotype for Thymidylate Synthase Expression Status in Patients with Advanced Lung Adenocarcinoma Using a Radiomics Approach.
Lung Neoplasms
Detection of circulating lung cancer cells with strong thymidylate synthase reactivity in the peripheral blood of a patient with pulmonary adenocarcinoma treated with pemetrexed.
Lung Neoplasms
Detection of resistance proteins in matched primary lung tumors and lymph node metastases.
Lung Neoplasms
Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer.
Lung Neoplasms
Differences in the efficacy of S-1 monotherapy according to histological type in pretreated patients with advanced non-small cell lung cancer.
Lung Neoplasms
Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung.
Lung Neoplasms
Downregulation of thymidylate synthase with arsenic trioxide in lung adenocarcinoma.
Lung Neoplasms
E2F1 overexpression correlates with thymidylate synthase and survivin gene expressions and tumor proliferation in non small-cell lung cancer.
Lung Neoplasms
Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging.
Lung Neoplasms
Early detection of thymidylate synthase resistance in non-small cell lung cancer with FLT-PET imaging.
Lung Neoplasms
Effect of thymidylate synthase gene polymorphism on the response to chemotherapy and clinical outcome of non-small cell lung cancer patients.
Lung Neoplasms
Effects of the combination of acivicin and cis-diamminedichloroplatinum(II) on thymidylate synthesis of A549 lung cancer cells.
Lung Neoplasms
Effects of UFT on thymidylate synthase and dihydropyrimidine dehydrogenase activities in lung cancer.
Lung Neoplasms
Evaluating the Prognostic Value of ERCC1 and Thymidylate Synthase Expression and the Epidermal Growth Factor Receptor Mutation Status in Adenocarcinoma Non-Small-Cell Lung Cancer.
Lung Neoplasms
Expression and pharmacological inhibition of thymidylate synthase and Src kinase in nonsmall cell lung cancer.
Lung Neoplasms
Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS).
Lung Neoplasms
Expression of Ribonucleotide Reductase Subunit-2 and Thymidylate Synthase Correlates with Poor Prognosis in Patients with Resected Stages I-III Non-Small Cell Lung Cancer.
Lung Neoplasms
Expression of thymidylate synthase in human non-small cell lung cancer.
Lung Neoplasms
Expression of thymidylate synthase is correlated with proliferative activity in non-small cell lung cancer (NSCLC).
Lung Neoplasms
Expression of thymidylate synthase predicts clinical outcomes of pemetrexed-containing chemotherapy for non-small-cell lung cancer: a systemic review and meta-analysis.
Lung Neoplasms
Expression of thymidylate synthase predicts clinical outcomes of S-1-based chemotherapy in squamous cell lung cancer.
Lung Neoplasms
FGF2-FGFR1 pathway activation together with thymidylate synthase upregulation is induced in pemetrexed-resistant lung cancer cells.
Lung Neoplasms
Higher Tissue Levels of Thymidylate Synthase Determined by ELISA Are Associated with Poor Prognosis of Patients with Lung Cancer.
Lung Neoplasms
Histologic subtype in NSCLC: does it matter?
Lung Neoplasms
Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21 expression.
Lung Neoplasms
Identification of thymidylate synthase as a potential therapeutic target for lung cancer.
Lung Neoplasms
IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells.
Lung Neoplasms
Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study.
Lung Neoplasms
Impact of thymidylate synthase protein expression on efficacy of chemotherapy in advanced lung cancer patients.
Lung Neoplasms
Improved assay method of dTMP synthase in rat liver and its application to human lung cancer cells.
Lung Neoplasms
In vitro sensitivity to platinum-derived drugs is associated with expression of thymidylate synthase and dihydropyrimidine dehydrogenase in human lung cancer.
Lung Neoplasms
Incorporation of pemetrexed (Alimta) into the treatment of non-small cell lung cancer (thoracic tumors).
Lung Neoplasms
Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression.
Lung Neoplasms
Influence of polymorphisms in MTHFR 677 C?T, TYMS 3R?2R and MTR 2756 A?G on NSCLC risk and response to platinum-based chemotherapy in advanced NSCLC.
Lung Neoplasms
Inhibition of dUTPase Induces Synthetic Lethality with Thymidylate Synthase-Targeted Therapies in Non-Small Cell Lung Cancer.
Lung Neoplasms
Intratumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase in non-small cell lung cancer patients treated with 5-FU-based chemotherapy.
Lung Neoplasms
Low thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase mRNA expression correlate with prolonged survival in resected non-small-cell lung cancer.
Lung Neoplasms
Multiplex real-time PCR for RRM1, XRCC1, TUBB3 and TS mRNA for prediction of response of non-small cell lung cancer to chemoradiotherapy.
Lung Neoplasms
New prognostic indicator for non-small-cell lung cancer, quantitation of thymidylate synthase by real-time reverse transcription polymerase chain reaction.
Lung Neoplasms
Nitroglycerin Enhances Cisplatin-Induced Cytotoxicity via AKT Inactivation and Thymidylate Synthase Downregulation in Human Lung Cancer Cells.
Lung Neoplasms
Pemetrexed disodium (Eli Lilly).
Lung Neoplasms
Pemetrexed for previously treated patients with non-small cell lung cancer and differences in efficacy according to thymidylate synthase expression.
Lung Neoplasms
Pemetrexed induced thymidylate synthase inhibition in non-small cell lung cancer patients: a pilot study with 3'-deoxy-3'-[¹?F]fluorothymidine positron emission tomography.
Lung Neoplasms
Pemetrexed Plus Cisplatin Versus Gemcitabine Plus Cisplatin According to Thymidylate Synthase Expression in Nonsquamous Non-Small-Cell Lung Cancer: A Biomarker-Stratified Randomized Phase II Trial.
Lung Neoplasms
Pemetrexed/Carboplatin/Bevacizumab followed by Maintenance Pemetrexed/Bevacizumab in Hispanic Patients with Non-Squamous Non-Small Cell Lung Cancer: Outcomes according to Thymidylate Synthase Expression.
Lung Neoplasms
Pharmacologic inhibition of mTOR antagonizes the cytotoxic activity of pemetrexed in non-small cell lung cancer.
Lung Neoplasms
Phase I Study of Lapatinib and Pemetrexed in the Second-Line Treatment of Advanced or Metastatic Non-Small-Cell Lung Cancer With Assessment of Circulating Cell Free Thymidylate Synthase RNA as a Potential Biomarker.
Lung Neoplasms
Phase II trial of raltitrexed ('Tomudex') in advanced small-cell lung cancer.
Lung Neoplasms
Plasma thymidylate synthase and dihydrofolate reductase mRNA levels as potential predictive biomarkers of pemetrexed sensitivity in patients with advanced non-small cell lung cancer.
Lung Neoplasms
Polymorphism rs3819102 in thymidylate synthase and environmental factors: effects on lung cancer in Chinese population.
Lung Neoplasms
Polymorphisms in thymidylate synthase and reduced folate carrier (SLC19A1) genes predict survival outcome in advanced non-small cell lung cancer patients treated with pemetrexed-based chemotherapy.
Lung Neoplasms
Predictive and Prognostic Value of 18F-fluorodeoxyglucose Uptake Combined with Thymidylate Synthase Expression in Patients with Advanced Non-Small Cell Lung Cancer.
Lung Neoplasms
Predictive Significance of Thymidylate Synthase Expression in Non-small Cell Lung Cancer.
Lung Neoplasms
Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase expression in tumor tissue, regarding the efficacy of postoperatively administered UFT (tegafur+uracil) in patients with non-small cell lung cancer.
Lung Neoplasms
Prognostic and Predictive Roles of Thymidylate Synthase Expression in Lung Cancer: The Debate Is Still Open.
Lung Neoplasms
Prognostic and predictive significance of thymidylate synthase protein expression in non-small cell lung cancer: a systematic review and meta-analysis.
Lung Neoplasms
Prognostic significance of the mRNA expression of ERCC1, RRM1, TUBB3 and TYMS genes in patients with non-small cell lung cancer.
Lung Neoplasms
Prognostic significance of the polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase gene in lung cancer.
Lung Neoplasms
Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients.
Lung Neoplasms
Prognostic value of ERCC1, RRM1, and TS proteins in patients with resected non-small cell lung cancer.
Lung Neoplasms
Protein and mRNA expression of folic acid-associated enzymes as biomarkers for the cytotoxicity of the thymidylate synthase-targeted drugs, pemetrexed and S-1, in non-small cell lung cancer.
Lung Neoplasms
Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer.
Lung Neoplasms
Salinomycin acts through reducing AKT-dependent thymidylate synthase expression to enhance erlotinib-induced cytotoxicity in human lung cancer cells.
Lung Neoplasms
Salinomycin enhances cisplatin-induced cytotoxicity in human lung cancer cells via down-regulation of AKT-dependent thymidylate synthase expression.
Lung Neoplasms
Significance of folate receptor alpha and thymidylate synthase protein expression in patients with non-small-cell lung cancer treated with pemetrexed.
Lung Neoplasms
Significance of Thymidylate Synthase and Thyroid Transcription Factor 1 Expression in Patients with Nonsquamous Non-small Cell Lung Cancer Treated with Pemetrexed-Based Chemotherapy.
Lung Neoplasms
Significance of thymidylate synthase for resistance to pemetrexed in lung cancer.
Lung Neoplasms
Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of gefitinib-induced down-regulation of thymidylate synthase.
Lung Neoplasms
The deubiquitinating enzyme UCHL1 promotes resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase.
Lung Neoplasms
The efficacy of pemetrexed as a third- or fourth-line therapy and the significance of thymidylate synthase expression in patients with advanced non-small cell lung cancer.
Lung Neoplasms
The ERK-ZEB1 pathway mediates epithelial-mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids.
Lung Neoplasms
The influence of methylenetetrahydrofolate reductase and thymidylate synthetase gene polymorphisms on lung adenocarcinoma occurrence.
Lung Neoplasms
The novel thymidylate synthase inhibitor trifluorothymidine (TFT) and TRAIL synergistically eradicate non-small cell lung cancer cells.
Lung Neoplasms
The pemetrexed-containing treatments in the non-small cell lung cancer, is -/low thymidylate synthase expression better than +/high thymidylate synthase expression: a meta-analysis.
Lung Neoplasms
The relationship between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase, excision repair cross-complementation group 1 and class III ?-tubulin, and the therapeutic effect of S-1 or carboplatin plus paclitaxel in non-small-cell lung cancer.
Lung Neoplasms
The role of thymidylate synthase and dihydropyrimidine dehydrogenase in resistance to 5-fluorouracil in human lung cancer cells.
Lung Neoplasms
The role of thymidylate synthase in non-small cell lung cancer treated with pemetrexed continuation maintenance therapy.
Lung Neoplasms
Thymidylate synthase (TS) gene expression in primary lung cancer patients: a large-scale study in Japanese population.
Lung Neoplasms
Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: The association with treatment efficacy of pemetrexed.
Lung Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase activities in non-small cell lung cancer tissues: relationship with in vitro sensitivity to 5-fluorouracil.
Lung Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase expression levels are associated with response to S-1 plus carboplatin in advanced non-small cell lung cancer.
Lung Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase in non-small cell lung cancer: relationship between mRNA expression and activity.
Lung Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in tumor tissues and the efficacy of 5-fluorouracil in patients with non-small-cell lung cancer.
Lung Neoplasms
Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer.
Lung Neoplasms
Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer.
Lung Neoplasms
Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung.
Lung Neoplasms
Thymidylate synthase expression and outcome of patients receiving pemetrexed for advanced nonsquamous non-small-cell lung cancer in a prospective blinded assessment phase II clinical trial.
Lung Neoplasms
Thymidylate synthase expression as a predictive biomarker of pemetrexed sensitivity in advanced non-small cell lung cancer.
Lung Neoplasms
Thymidylate synthase expression in high-grade neuroendocrine and non-small cell lung cancer histotypes--is it ready for primetime?
Lung Neoplasms
Thymidylate synthase expression is closely associated with outcome in patients with pulmonary adenocarcinoma.
Lung Neoplasms
Thymidylate synthase gene amplification predicts pemetrexed resistance in patients with advanced non-small cell lung cancer.
Lung Neoplasms
Thymidylate synthase in situ protein expression and survival in stage I nonsmall-cell lung cancer.
Lung Neoplasms
Thymidylate synthase inhibitors for non-small cell lung cancer.
Lung Neoplasms
Thymidylate Synthase Polymorphisms and Risk of Lung Cancer among the Jordanian Population: a Case Control Study.
Lung Neoplasms
Thymidylate synthase polymorphisms are associated to therapeutic outcome of advanced non-small cell lung cancer patients treated with platinum-based chemotherapy.
Lung Neoplasms
Thymidylate synthase polymorphisms in genomic DNA as clinical outcome predictors in a European population of advanced non-small cell lung cancer patients receiving pemetrexed.
Lung Neoplasms
Thymidylate synthase protein expression by IHC and gene copy number by SISH correlate and show great variability in non-small cell lung cancer.
Lung Neoplasms
Thymidylate synthase protein expression levels remain stable during paclitaxel and carboplatin treatment in non-small cell lung cancer.
Lung Neoplasms
Thymidylate Synthase, Dihydropyrimidine Dehydrogenase, Thymidine Phosphorylase, Orotate Phosphoribosyltransferase mRNA Expression in Lung Cancer Metastatic Lymph Node Samples Obtained by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration - A Pilot Study.
Lung Neoplasms
Up-regulation of ERK1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small cell lung cancer cells.
Lung Neoplasms
Updated clinical information on multitargeted antifolates in lung cancer.
Lung Neoplasms
[Effect of pemetrexed plus platinum for chemotherapy-naive advanced non-small cell lung cancer].
Lyme Disease
Function and evolution of plasmid-borne genes for pyrimidine biosynthesis in Borrelia spp.
Lymphatic Metastasis
Detection of resistance proteins in matched primary lung tumors and lymph node metastases.
Lymphatic Metastasis
Detection of thymidylate synthase expression in lymph node metastases of colorectal cancer can improve the prognostic information.
Lymphatic Metastasis
Effects of UFT on thymidylate synthase and dihydropyrimidine dehydrogenase activities in lung cancer.
Lymphatic Metastasis
Expression of TYMS in lymph node metastasis from low-grade glioma.
Lymphatic Metastasis
Molecular Predictors of Lymph Node Metastasis in Colon Cancer: Increased Risk With Decreased Thymidylate Synthase Expression.
Lymphatic Metastasis
Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis.
Lymphatic Metastasis
TYMS serves as a prognostic indicator to predict the lymph node metastasis in Chinese patients with colorectal cancer.
Lymphatic Metastasis
[Association of thymidylate synthase polymorphism with esophageal squamous-cell carcinoma]
Lymphatic Metastasis
[Expression of some biomarkers in primary colon adenocarcinomas and their lymph node metastases].
Lymphatic Metastasis
[Polymorphisms of thymidylate synthase gene and correlation of its protein expression to lymph node metastasis of esophageal squamous cell carcinoma]
Lymphoma
5,10-Methylenetetrahydro-5-deazafolic acid and analogues: synthesis and biological activities.
Lymphoma
Association between EML4-ALK fusion gene and thymidylate synthase mRNA expression in non-small cell lung cancer tissues.
Lymphoma
Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma.
Lymphoma
Human herpesvirus 8 gene encodes a functional thymidylate synthase.
Lymphoma
Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.
Lymphoma
Rechallenge with pemetrexed-based chemotherapy improves the survival of patients with advanced non-squamous non-small-cell lung cancer.
Lymphoma
The potentiation of radiation response in human colon carcinoma cells in vitro and murine lymphoma in vivo by AG337 (Thymitaq), a novel thymidylate synthase inhibitor.
Lymphoma
Use of murine L5178Y lymphoma thymidine kinase mutants for in vitro and in vivo antitumour efficacy evaluation of novel thymidylate synthase inhibitors.
Lymphoma, B-Cell
Predictive biomarkers for combined chemotherapy with 5-fluorouracil and cisplatin in oro- and hypopharyngeal cancers.
Lymphoma, Non-Hodgkin
Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography.
Lymphoma, Non-Hodgkin
The association between polymorphic sites in the thymidylate synthase (TYMS) gene and risk of non-Hodgkin lymphoma: a systematic review and pooled analysis.
Malaria
Characterisation of the dihydrofolate reductase-thymidylate synthetase gene from human malaria parasites highly resistant to pyrimethamine.
Malaria
Dihydrofolate reductase: thymidylate synthase, a bifunctional polypeptide from Crithidia fasciculata.
Malaria
Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.
Malaria
Functional expression of the dihydrofolate reductase and thymidylate synthetase activities of the human malaria parasite Plasmodium falciparum in Escherichia coli.
Malaria
High-performance liquid chromatographic assay for thymidylate synthase from the human malaria parasite, Plasmodium falciparum.
Malaria
Loop-Mediated Isothermal Amplification and LFD Combination for Detection of Plasmodium falciparum and Plasmodium vivax.
Malaria
Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum.
Malaria
Resistance of a rodent malaria parasite to a thymidylate synthase inhibitor induces an apoptotic parasite death and imposes a huge cost of fitness.
Malaria
Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase.
Malaria
Substituted pyrrolo[2,3-d]pyrimidines as Cryptosporidium hominis thymidylate synthase inhibitors.
Malaria
The interaction of 5-fluoroorotic acid with transition metals: synthesis and characterisation of Ni(II), Cu(II) and Zn(II) complexes.
Mastocytoma
Inhibition of thymidylate synthase by hydroxyurea in rapidly proliferating P815 mastocytoma cells.
Medulloblastoma
Rethinking medulloblastoma from a targeted therapeutics perspective.
Melanoma
Accumulation of DNA strand breaks in cells exposed to methotrexate or N10-propargyl-5,8-dideazafolic acid.
Melanoma
Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines.
Melanoma
Comparison of the inhibitory effects of hydroxyurea, 5-fluorodeoxyuridine, 3,4-dihydroxybenzylamine, and methotrexate on human squamous cell carcinoma.
Melanoma
Dual addressing of thymidine synthesis pathways for effective targeting of proliferating melanoma.
Melanoma
Generation of varicella-zoster virus (VZV) and viral mutants from cosmid DNAs: VZV thymidylate synthetase is not essential for replication in vitro.
Melanoma
Increased thymidylate synthase gene expression in metastatic melanoma.
Melanoma
Mechanism(s) regulating inhibition of thymidylate synthase and growth by gamma-L-glutaminyl-4-hydroxy-3-iodobenzene, a novel melanin precursor, in melanogenic melanoma cells.
Melanoma
New thymidylate synthase inhibitors induce apoptosis in melanoma cell lines.
Melanoma
Prognostic significance of thymidylate synthase (TS) expression in cutaneous malignant melanoma.
Melanoma
Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion.
Melanoma
The properdin-like type I repeats of human thrombospondin contain a cell attachment site.
Melanoma
Thymidylate synthase as a target enzyme for the melanoma-specific toxicity of 4-S-cysteaminylphenol and N-acetyl-4-S-cysteaminylphenol.
Meningioma
Microarray analysis reveals down-regulation of the tumour suppressor gene WWOX and up-regulation of the oncogene TYMS in intracranial sporadic meningiomas.
Mental Retardation, X-Linked
Assignment of human gene encoding thymidylate synthase to chromosome 18 using interspecific cell hybrids between thymidylate synthase-negative mouse mutant cells and human diploid fibroblasts.
Mesothelioma
An RNAi therapeutic, DFP-10825, for intraperitoneal and intrapleural malignant cancers.
Mesothelioma
Antimetabolites and cancer: emerging data with a focus on antifolates.
Mesothelioma
Biomarkers and prognostic factors for malignant pleural mesothelioma.
Mesothelioma
Dasatinib modulates sensitivity to pemetrexed in malignant pleural mesothelioma cell lines.
Mesothelioma
Downregulation of thymidylate synthase and E2F1 by arsenic trioxide in mesothelioma.
Mesothelioma
Excision repair cross complementation group 1 and thymidylate synthase expression in patients with mesothelioma.
Mesothelioma
Genome-wide profile of pleural mesothelioma versus parietal and visceral pleura: the emerging gene portrait of the mesothelioma phenotype.
Mesothelioma
Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression.
Mesothelioma
Pemetrexed disodium (Eli Lilly).
Mesothelioma
Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin.
Mesothelioma
Reduced Folate Carrier and Folylpolyglutamate Synthetase, but not Thymidylate Synthase Predict Survival in Pemetrexed-Treated Patients Suffering from Malignant Pleural Mesothelioma.
Mesothelioma
Role of proton-coupled folate transporter in pemetrexed-resistance of mesothelioma: clinical evidence and new pharmacological tools.
Mesothelioma
Therapeutic potential of antisense oligodeoxynucleotides to down-regulate thymidylate synthase in mesothelioma.
Mesothelioma
THYMIDYLATE SYNTHASE AND EXCISION REPAIR-CROSS-COMPLEMENTING GROUP-1 AS PREDICTORS OF RESPONSIVENESS IN MESOTHELIOMA PATIENTS TREATED WITH PEMETREXED-CARBOPLATIN.
Mesothelioma
Thymidylate Synthase and Folyl-Polyglutamate Synthase Are Not Clinically Useful Markers of Response to Pemetrexed in Patients with Malignant Pleural Mesothelioma.
Mesothelioma
Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy.
Mesothelioma, Malignant
An RNAi therapeutic, DFP-10825, for intraperitoneal and intrapleural malignant cancers.
Mesothelioma, Malignant
Dasatinib modulates sensitivity to pemetrexed in malignant pleural mesothelioma cell lines.
Mesothelioma, Malignant
Downregulation of thymidylate synthase by RNAi molecules enhances the antitumor effect of pemetrexed in an orthotopic malignant mesothelioma xenograft mouse model.
Mesothelioma, Malignant
Excision repair cross complementation group 1 and thymidylate synthase expression in patients with mesothelioma.
Mesothelioma, Malignant
New tricks for old biomarkers: thymidylate synthase expression as a predictor of pemetrexed activity in malignant mesothelioma.
Mesothelioma, Malignant
Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin.
Mesothelioma, Malignant
Reduced Folate Carrier and Folylpolyglutamate Synthetase, but not Thymidylate Synthase Predict Survival in Pemetrexed-Treated Patients Suffering from Malignant Pleural Mesothelioma.
Mesothelioma, Malignant
Therapeutic potential of antisense oligodeoxynucleotides to down-regulate thymidylate synthase in mesothelioma.
Mesothelioma, Malignant
Thymidylate Synthase and Folyl-Polyglutamate Synthase Are Not Clinically Useful Markers of Response to Pemetrexed in Patients with Malignant Pleural Mesothelioma.
Mesothelioma, Malignant
Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy.
Migraine Disorders
Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele.
Mouth Neoplasms
Differentiation-inducing factor-1 enhances 5-fluorouracil action on oral cancer cells inhibiting E2F1 and thymidylate synthase mRNAs accumulation.
Mouth Neoplasms
[Immunohistochemical and clinicopathological study of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyl transferase expression in oral cancer patients responding to UFT]
Mucositis
Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group.
Multiple Myeloma
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk.
Myasthenia Gravis
The thymidylate synthase enhancer region (TSER) polymorphism increases the risk of thymic lymphoid hyperplasia in patients with Myasthenia Gravis.
Nasopharyngeal Carcinoma
Matrix metalloproteinase 1 promotes tumorigenesis and inhibits the sensitivity to 5-fluorouracil of nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Overexpression of thymidylate synthetase confers an independent prognostic indicator in nasopharyngeal carcinoma.
Nasopharyngeal Neoplasms
High expression of excision repair cross-complementation group 1 protein predicts poor outcome in patients with nasopharyngeal cancer.
Neoplasm Metastasis
Amplification of thymidylate synthetase in metastatic colorectal cancer patients pretreated with 5-fluorouracil-based chemotherapy.
Neoplasm Metastasis
Analysis of the mRNA Expression Levels of Thymidylate Synthase (TS), Dihydropyrimidine Dehydrogenase (DPD) and Orotate Phosphoribosyl Transferase (OPRT) in Liver Metastases from Colorectal Cancer.
Neoplasm Metastasis
Can we improve the clinical risk score? The prognostic value of p53, Ki-67 and thymidylate synthase in patients undergoing radical resection of colorectal liver metastases.
Neoplasm Metastasis
Colorectal liver metastasis thymidylate synthase staining correlates with response to hepatic arterial floxuridine.
Neoplasm Metastasis
Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance.
Neoplasm Metastasis
Detection of resistance proteins in matched primary lung tumors and lymph node metastases.
Neoplasm Metastasis
Detection of thymidylate synthase expression in lymph node metastases of colorectal cancer can improve the prognostic information.
Neoplasm Metastasis
Do the expression of CD44, apoptosis and thymidylate synthase inhibition rate correlate with the efficacy of chemotherapy in colorectal cancer?
Neoplasm Metastasis
Effects of UFT on thymidylate synthase and dihydropyrimidine dehydrogenase activities in lung cancer.
Neoplasm Metastasis
Expression of dihydropyrimidine dehydrogenase, orotate phosphoribosyl transferase and thymidylate synthase in patients with primary colorectal cancer, and associations with site of first metastasis.
Neoplasm Metastasis
Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in primary oral squamous cell carcinoma and corresponding metastases in cervical lymph nodes: association with the metastasis suppressor CD82.
Neoplasm Metastasis
Expression of thymidylate synthase in liver and lung metastases of colorectal cancer and their matched primary tumours.
Neoplasm Metastasis
Expression of TYMS in lymph node metastasis from low-grade glioma.
Neoplasm Metastasis
Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma.
Neoplasm Metastasis
Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy.
Neoplasm Metastasis
Increased thymidylate synthase gene expression in liver metastases from colorectal carcinoma: implications for chemotherapeutic options and survival.
Neoplasm Metastasis
Is thymidylate synthase a reliable predictor for response and survival during hepatic arterial infusion for hepatic metastases from colorectal cancer?
Neoplasm Metastasis
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
Neoplasm Metastasis
Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase.
Neoplasm Metastasis
Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients.
Neoplasm Metastasis
Molecular Predictors of Lymph Node Metastasis in Colon Cancer: Increased Risk With Decreased Thymidylate Synthase Expression.
Neoplasm Metastasis
Molecular profiling of a case of advanced pancreatic cancer identifies an active and tolerable combination of targeted therapy with backbone chemotherapy.
Neoplasm Metastasis
p53, DCC and thymidylate synthase as predictors of survival after resection of hepatic metastases from colorectal cancer.
Neoplasm Metastasis
Perspectives on new chemotherapeutic agents in the treatment of colorectal cancer.
Neoplasm Metastasis
Pharmacogenomics of fluorouracil, irinotecan, and oxaliplatin in hepatic metastases of colorectal cancer: clinical implications.
Neoplasm Metastasis
Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors.
Neoplasm Metastasis
Predictive factors for long-term responders of pemetrexed maintenance treatment in non-small cell lung cancer.
Neoplasm Metastasis
Predictive molecular markers for colorectal cancer patients with resected liver metastasis and adjuvant chemotherapy.
Neoplasm Metastasis
Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients.
Neoplasm Metastasis
Predictive value of thymidylate synthase expression in resected metastases of colorectal cancer.
Neoplasm Metastasis
Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis.
Neoplasm Metastasis
Prognostic significance of thymidylate synthase expression in the adjuvant chemotherapy after resection for pulmonary metastases from colorectal cancer.
Neoplasm Metastasis
Proteomics of Sentinel Lymph Nodes in Early Breast Cancer for Identification of Thymidylate Synthase as a Potential Biomarker to Flag Metastasis: A Preliminary Study.
Neoplasm Metastasis
Shifting from clinical to biologic indicators of prognosis after resection of hepatic colorectal metastases.
Neoplasm Metastasis
Structural analysis of cDNA encoding thymidylate synthase in hepatic metastases of human colorectal tumors.
Neoplasm Metastasis
Thymidylate synthase and microsatellite instability in colorectal cancer: Implications for disease free survival, treatment response and survival with metastases.
Neoplasm Metastasis
Thymidylate synthase and thymidine phosphorylase mRNA expression in primary lesions using laser capture microdissection is useful for prediction of the efficacy of FOLFOX treatment in colorectal cancer patients with liver metastasis.
Neoplasm Metastasis
Thymidylate synthase expression in primary colorectal cancer as a predictive marker for the response to 5-fluorouracil- and oxaliplatin-based preoperative chemotherapy for liver metastases.
Neoplasm Metastasis
Thymidylate synthase expression in primary colorectal tumours is correlated with its expression in metastases.
Neoplasm Metastasis
Thymidylate synthase expression: an independent prognostic factor for local recurrence, distant metastasis, disease-free and overall survival in rectal cancer.
Neoplasm Metastasis
Thymidylate synthase in nodal metastases: prognostic for chemosensitivity but not for adjuvant therapy?
Neoplasm Metastasis
Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy.
Neoplasm Metastasis
Thymidylate synthase protein expression in advanced colon cancer: correlation with the site of metastasis and the clinical response to leucovorin-modulated bolus 5-fluorouracil.
Neoplasm Metastasis
Thymidylate synthase protein expression in colorectal cancer metastases predicts for clinical outcome to leucovorin-modulated bolus or infusional 5-fluorouracil but not methotrexate-modulated bolus 5-fluorouracil.
Neoplasm Metastasis
Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil.
Neoplasm Metastasis
Thymidylate synthase: a predictive biomarker in resected colorectal liver metastases receiving 5-FU treatment.
Neoplasm Metastasis
Thymidylate synthetase mRNA levels are increased in liver metastases of colorectal cancer patients resistant to fluoropyrimidine-based chemotherapy.
Neoplasm Metastasis
TYMS serves as a prognostic indicator to predict the lymph node metastasis in Chinese patients with colorectal cancer.
Neoplasm Metastasis
[Antimetastatic and antitumor effects of fluoropyrimidines alone and combined with taxanes in a murine model of breast cancer metastatic to the lung]
Neoplasm Metastasis
[Expression of some biomarkers in primary colon adenocarcinomas and their lymph node metastases].
Neoplasm Metastasis
[Polymorphisms of thymidylate synthase gene and correlation of its protein expression to lymph node metastasis of esophageal squamous cell carcinoma]
Neoplasm Metastasis
[Prediction of the efficacy of modified FOLFOX6 therapy according to the mRNA levels of thymidylate synthase (TS), excision repair cross-complementing-1 and -2( ERCC-1 and ERCC-2) and methylenetetrahydrofolate dehydrogenase( MTHFD) in the primary lesion of colorectal cancer].
Neoplasm Metastasis
[Results of prophylactic hepatic arterial chemotherapy for liver metastases of Dukes C colorectal cancer--correlation with tumoral expression of dihydropyrimidine dehydrogenase, thymidylate synthase, p53, or orotate phosphoribosyl transferase]
Neoplasm, Residual
Pharmacogenetic Study in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy: Polymorphisms in Thymidylate Synthase, Epidermal Growth Factor Receptor, GSTP1, and DNA Repair Genes.
Neoplasm, Residual
Thymidylate synthase germline polymorphisms in rectal cancer patients treated with neoadjuvant chemoradiotherapy based on 5-fluorouracil.
Neoplasms
1,3,4-Oxadiazoles: An emerging scaffold to target growth factors, enzymes and kinases as anticancer agents.
Neoplasms
1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil suppresses mammary carcinogenesis and growth of tumors induced with 7,12-dimethylbenz[a]anthracene in rats.
Neoplasms
18F-FLT and 125I-IdUrd uptake increase in human tumour cell lines induced by the thymidylate synthase inhibitor FdUrd.
Neoplasms
19F nuclear magnetic resonance imaging of drug distribution in vivo: the disposition of an antifolate anticancer drug in mice.
Neoplasms
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
Neoplasms
3'-Deoxy-3'-[18F]fluorothymidine positron emission tomography imaging of thymidine kinase 1 activity after 5-fluorouracil treatment in a mouse tumor model.
Neoplasms
5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells.
Neoplasms
5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers.
Neoplasms
5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation.
Neoplasms
5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine.
Neoplasms
5-fluorouracil-mediated thymidylate synthase induction in malignant and nonmalignant human cells.
Neoplasms
5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates.
Neoplasms
5-fluorouracil: a pharmacological paradigm in the use of cytotoxics.
Neoplasms
5-Substituted 2'-deoxyuridines: correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase.
Neoplasms
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
Neoplasms
A "combination oligonucleotide" antisense strategy to downregulate thymidylate synthase and decrease tumor cell growth and drug resistance.
Neoplasms
A comprehensive analysis of BRCA2 gene: focus on mechanistic aspects of its functions, spectrum of deleterious mutations, and therapeutic strategies targeting BRCA2-deficient tumors.
Neoplasms
A dose-finding study of raltitrexed (tomudex) with cisplatin and epirubicin in advanced gastro-oesophageal adenocarcinoma.
Neoplasms
A fast chemoenzymatic synthesis of [(11)C]-N(5),N(10)-methylenetetrahydrofolate as a potential PET tracer for proliferating cells.
Neoplasms
A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation.
Neoplasms
A longterm follow-up study of thymidylate synthase as a predictor for survival of patients with liver tumours receiving hepatic arterial infusion chemotherapy.
Neoplasms
A naturally occurring tyrosine to histidine replacement at residue 33 of human thymidylate synthase confers resistance to 5-fluoro-2'-deoxyuridine in mammalian and bacterial cells.
Neoplasms
A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2'-deoxyuridine in a human colon tumor cell line.
Neoplasms
A new prognostic factor for colorectal carcinoma, thymidylate synthase, and its therapeutic significance.
Neoplasms
A new quantitative RT-PCR assay for thymidylate synthase mRNA in blood leukocytes applied to cancer patients and healthy controls.
Neoplasms
A novel approach to thymidylate synthase as a target for cancer chemotherapy.
Neoplasms
A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Neoplasms
A phase I and pharmacokinetic study of 1843U89, a noncompetitive inhibitor of thymidylate synthase, in patients with advanced solid malignancies.
Neoplasms
A phase I and pharmacokinetic study of the nonpolyglutamatable thymidylate synthase inhibitor ZD9331 plus docetaxel in patients with advanced solid malignancies.
Neoplasms
A phase I pharmacokinetic and pharmacodynamic study of BGC9331 and carboplatin in relapsed gynaecological malignancies.
Neoplasms
A phase I study of 5-fluorouracil/leucovorin and arsenic trioxide for patients with refractory/relapsed colorectal carcinoma.
Neoplasms
A Phase I study of raltitrexed, an antifolate thymidylate synthase inhibitor, in adult patients with advanced solid tumors.
Neoplasms
A Phase I study of weekly intravenous oxaliplatin in combination with oral daily capecitabine and radiation therapy in the neoadjuvant treatment of rectal adenocarcinoma.
Neoplasms
A phase II study in advanced breast cancer: ZD1694 ('Tomudex') a novel direct and specific thymidylate synthase inhibitor.
Neoplasms
A pilot study of interferon alpha-2a, fluorouracil, and leucovorin given with granulocyte-macrophage colony stimulating factor in advanced gastrointestinal adenocarcinoma.
Neoplasms
A possible link to uracil DNA glycosylase in the synergistic action of HDAC inhibitors and thymidylate synthase inhibitors.
Neoplasms
A potent multisubstrate analogue inhibitor of human thymidylate synthetase.
Neoplasms
A potential important role for thymidylate synthetase inhibition on antitumor activity of fluoropyrimidine and raltitexed.
Neoplasms
A Proposed Clinical Test for Monitoring Fluoropyrimidine Therapy: Detection and Stability of Thymidylate Synthase Ternary Complexes.
Neoplasms
A Prospective Pilot Study of Target-guided Personalized Chemotherapy with Intensity-modulated Radiotherapy in Patients With Early Rectal Cancer.
Neoplasms
A qualitative approach to enzyme inhibition.
Neoplasms
A randomised phase II study of OSI-7904L versus 5-fluorouracil (FU)/leucovorin (LV) as first-line treatment in patients with advanced biliary cancers.
Neoplasms
A rationale for the clinical development of the thymidylate synthase inhibitor ZD9331 in ovarian and other solid tumours.
Neoplasms
A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil.
Neoplasms
A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803.
Neoplasms
Accomplishments in 2007 in biologic markers for gastrointestinal cancers.
Neoplasms
Activity of the cytosolic isozyme of thymidine kinase in human primary lung tumors with reference to malignancy.
Neoplasms
Acyclic analogues of 5-fluoro-dUMP and 5-fluoro-2'-deoxyuridine: synthesis and inhibition of thymidylate synthase and tumour cell growth.
Neoplasms
Additional effects of medroxyprogesterone acetate on mammary tumors in oophorectomized, estrogenized, DMBA-treated rats.
Neoplasms
Additive effects of medroxyprogesterone acetate and 5-fluorouracil derivative on 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors.
Neoplasms
Administration of adjuvant oral tegafur/uracil chemotherapy post hepatocellular carcinoma resection: A randomized controlled trial.
Neoplasms
alpha-fluoro-beta-alanine: effects on the antitumor activity and toxicity of 5-fluorouracil.
Neoplasms
Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients.
Neoplasms
An RNAi therapeutic, DFP-10825, for intraperitoneal and intrapleural malignant cancers.
Neoplasms
Analysis of 320 gastroenteropancreatic neuroendocrine tumors identifies TS expression as independent biomarker for survival.
Neoplasms
Antifolate agents: a patent review (2010 - 2013).
Neoplasms
Antifolate drug interactions: enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate.
Neoplasms
Antifolate Inhibitors of Thymidylate Synthase as Anticancer Drugs.
Neoplasms
Antimetabolites and cancer: emerging data with a focus on antifolates.
Neoplasms
Antimetabolites.
Neoplasms
Antisense nucleic acids targeted to the thymidylate synthase (TS) mRNA translation start site stimulate TS gene transcription.
Neoplasms
Antisense targeting of thymidylate synthase (TS) mRNA increases TS gene transcription and TS protein: effects on human tumor cell sensitivity to TS enzyme-inhibiting drugs.
Neoplasms
Antitumor activity and low intestinal toxicity of S-1, a new formulation of oral tegafur, in experimental tumor models in rats.
Neoplasms
Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats.
Neoplasms
Antitumor activity of fluoropyrimidines and thymidylate synthetase inhibition.
Neoplasms
Antitumor activity of oxaliplatin in combination with 5-fluorouracil and the thymidylate synthase inhibitor AG337 in human colon, breast and ovarian cancers.
Neoplasms
Antitumor effect of combination of S-1 and docetaxel on the human breast cancer xenograft transplanted into SCID mice.
Neoplasms
Antitumour activity, toxicity and inhibition of thymidylate synthase of prolonged administration of 5-fluorouracil in mice.
Neoplasms
Antitumour effects of pure diastereoisomers of 5-formyltetrahydrofolate in hepatic transplants of a rodent colon carcinoma model.
Neoplasms
AQP5 silencing suppresses p38 MAPK signaling and improves drug resistance in colon cancer cells.
Neoplasms
Assessment of thymidylate synthase expression in biopsy specimens and corresponding resection specimens of non-small-cell lung cancer.
Neoplasms
Association Between Genetic Polymorphisms In TYMS And Glioma Risk In Chinese Patients: A Case-Control Study.
Neoplasms
Association of gastric and intestinal phenotypic marker expression of gastric carcinomas with tumor thymidylate synthase expression and response to postoperative chemotherapy with 5-fluorouracil.
Neoplasms
Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population.
Neoplasms
Association of the thymidylate synthase polymorphisms with esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma.
Neoplasms
Association of thymidylate synthase and hypoxia inducible factor-1alpha DNA polymorphisms with pancreatic cancer.
Neoplasms
Association of thymidylate synthase polymorphisms with the tumor response to preoperative chemoradiotherapy in rectal cancer: a systematic review and meta-analysis.
Neoplasms
beta-Carboline-benzoquinolizidine alkaloid deoxytubulosine inhibits thymidylate synthase activity in leukemic leukocytes from patients with chronic myeloblastic leukemia and acute lymphoblastic leukemia.
Neoplasms
BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors.
Neoplasms
Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells.
Neoplasms
Biochemical and pharmacologic rationale for high-dose methotrexate.
Neoplasms
Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase.
Neoplasms
Biochemical mechanisms in colon xenografts: thymidylate synthase as a target for therapy.
Neoplasms
Biochemical modulation by 5-fluorouracil and 1-folinic acid of tumor uptake of intra-arterial 5-[123I]iodo-2'deoxyuridine in patients with liver metastases from colorectal cancer.
Neoplasms
Biochemical modulation of 5-bromo-2'-deoxyuridine and 5-iodo-2'-deoxyuridine incorporation into DNA in VX2 tumor-bearing rabbits.
Neoplasms
Biochemical modulation of 5-fluorouracil with a streptococcal preparation, OK-432, against murine colon-26 carcinoma.
Neoplasms
Biochemical modulation of 5-fluorouracil with interferon alpha/beta and gamma on murine renal cell carcinoma.
Neoplasms
Biochemical modulation of 5-fluorouracil with murine interferon-alpha/beta against murine renal cell carcinoma.
Neoplasms
Biochemical modulation of iododeoxyuridine by N6-[4-(morpholinosulfonyl)benzyl]-N6-methyl-2,6-diaminobenz[cd]indole glucuronate (AG-331) leading to enhanced cytotoxicity.
Neoplasms
Biochemical modulation of tumor cell energy: regression of advanced spontaneous murine breast tumors with a 5-fluorouracil-containing drug combination.
Neoplasms
Biological markers as a predictor for response and prognosis of unresectable gastric cancer patients treated with 5-fluorouracil and cis-platinum.
Neoplasms
Biological predictive factors in rectal cancer treated with preoperative radiotherapy or radiochemotherapy.
Neoplasms
Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach.
Neoplasms
Biopsy specimen microvessel density is a useful prognostic marker in patients with T(2-4)M(0) esophageal cancer treated with chemoradiotherapy.
Neoplasms
Cell death in response to antimetabolites directed at thymidylate synthase.
Neoplasms
Cellular and molecular mechanisms of resistance to antifolate drugs: new analogues and approaches to overcome the resistance.
Neoplasms
Cellular heterogeneity in DNA damage and growth inhibition induced by ICI D1694, thymidylate synthase inhibitor, using single cell assays.
Neoplasms
CES2, ABCG2, TS and Topo-I primary and synchronous metastasis expression and clinical outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI regimen.
Neoplasms
Changes in thymidylate synthase and its inhibition rate and changes in dihydropyrimidine dehydrogenase after the administration of 5-fluorouracil with cisplatin to nude mice with gastric cancer xenograft SC-1-NU.
Neoplasms
Characterization of the pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in xenografts of human colon adenocarcinoma.
Neoplasms
Chemo-immunotherapy of metastatic colorectal carcinoma with gemcitabine plus FOLFOX 4 followed by subcutaneous granulocyte macrophage colony-stimulating factor and interleukin-2 induces strong immunologic and antitumor activity in metastatic colon cancer patients.
Neoplasms
Chemosensitivity testing--present and future in Japan.
Neoplasms
Chemotherapeutic drugs may be used to enhance the killing efficacy of human tumor antigen peptide-specific CTLs.
Neoplasms
Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index.
Neoplasms
Clinical application of biological markers for treatments of resectable non-small-cell lung cancers.
Neoplasms
Clinical evaluation of postoperative chemotherapy based on genetic testing in patients with stage IIIA non-small cell lung cancer.
Neoplasms
Clinical experience with pemetrexed in breast cancer.
Neoplasms
Clinical Experience With Pemetrexed in Breast Cancer.
Neoplasms
Clinical implications of 5-FU modulation.
Neoplasms
Clinical implications of immunoreactivity of thymidylate synthase and dihydropyrimidine dehydrogenase in gastric cancer treated with oral fluoropyrimidine (S-1). Study Group of S-1 for Gastric Cancer.
Neoplasms
Co-administration of liposomal l-OHP and PEGylated TS shRNA-lipoplex: A novel approach to enhance anti-tumor efficacy and reduce the immunogenic response to RNAi molecules.
Neoplasms
CoFactor (Biokeys Pharmaceuticals).
Neoplasms
Colorectal carcinomas with microsatellite instability display increased thymidylate synthase gene expression levels.
Neoplasms
Column-switching high-performance liquid chromatographic method for the determination of a thymidylate synthase inhibitor, LY231514, an investigational agent for the treatment of solid tumors, in human plasma.
Neoplasms
Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer.
Neoplasms
Combination of oral fluoropyrimidine and docetaxel: reappraisal of synergistic effect against gastric carcinoma xenografts.
Neoplasms
Combination of thymidine phosphorylase gene transfer and deoxyinosine treatment greatly enhances 5-fluorouracil antitumor activity in vitro and in vivo.
Neoplasms
Combination silencer RNA (siRNA) targeting Bcl-2 antagonizes siRNA against thymidylate synthase in human tumor cell lines.
Neoplasms
Combination studies with 3'-azido-3'-deoxythymidine (AZT) plus ICI D1694. Cytotoxic and biochemical effects.
Neoplasms
Combining Small Interfering RNAs Targeting Thymidylate Synthase and Thymidine Kinase 1 or 2 Sensitizes Human Tumor Cells to 5-Fluorodeoxyuridine and Pemetrexed.
Neoplasms
Comparative analysis of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in colorectal cancer and surrounding normal tissue.
Neoplasms
Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.
Neoplasms
Comparative cytotoxicity of folate-based inhibitors of thymidylate synthase and 5-fluorouracil +/- leucovorin in MGH-U1 cells.
Neoplasms
Comparing cell kinetic studies of the effect of ftorafur and 5-fluorouracil on the L 1210 ascites tumor.
Neoplasms
Comparison of 5-fluorouracil-related gene expression levels between adenocarcinomas and squamous cell carcinomas of the lung.
Neoplasms
Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
Neoplasms
Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance.
Neoplasms
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth.
Neoplasms
Constitutive expression of thymidylate synthase from LCDV-C induces a transformed phenotype in fish cells.
Neoplasms
Constitutive nuclear factor-kappa B mRNA, protein overexpression and enhanced DNA-binding activity in thymidylate synthase inhibitor-resistant tumour cells.
Neoplasms
Contributions of protein structure-based drug design to cancer chemotherapy.
Neoplasms
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones?
Neoplasms
Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors.
Neoplasms
Copy-number analysis of topoisomerase and thymidylate synthase genes in frozen and FFPE DNAs of colorectal cancers.
Neoplasms
Correction for Cardinale et al. , Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase.
Neoplasms
Correlation between 5-fluorouracil metabolism and treatment response in two variants of C26 murine colon carcinoma.
Neoplasms
Correlation between expression of thymidylate synthase and clinical outcome of advanced gastric cancer treated with capecitabine alone chemotherapy.
Neoplasms
Correlation of Expression Levels of Copper Transporter 1 and Thymidylate Synthase with Treatment Outcomes in Patients with Advanced Non-small Cell Lung Cancer Treated with S-1/Carboplatin Doublet Chemotherapy
Neoplasms
Correlation of spectral imaging and visual grading for the quantification of thymidylate synthase protein expression in rectal cancer.
Neoplasms
Correlations between antitumor activities of fluoropyrimidines and DPD activity in lung tumor xenografts.
Neoplasms
Correlations of Clinicopathological Factors with Protein Expression Levels of Thymidylate Synthase, Dihydropyrimidine Dehydrogenase and Orotate Phosphoribosyltransferase in Colorectal Cancer.
Neoplasms
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth.
Neoplasms
Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex.
Neoplasms
Cytotoxic response of 5-fluorouracil-resistant cells to gene- and cell-directed enzyme/prodrug treatment.
Neoplasms
Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and with benefit from one course of perioperative chemotherapy in patients with negative lymph node status: results from International Breast Cancer Study Group Trial V.
Neoplasms
Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance.
Neoplasms
Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones.
Neoplasms
Design, synthesis and in vitro antiproliferative activity of new thiazolidinedione-1,3,4-oxadiazole hybrids as thymidylate synthase inhibitors.
Neoplasms
Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents.
Neoplasms
Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor 1843U89 at physiological thymidine concentrations.
Neoplasms
Detection of resistance proteins in matched primary lung tumors and lymph node metastases.
Neoplasms
Detection of thymidylate synthase modulators by a novel screening assay.
Neoplasms
Determination of thymidine phosphorylase expression level facilitates recurrence risk stratification in stage II/III colorectal cancer following adjuvant chemotherapy with oral fluoropyrimidines.
Neoplasms
Determination of thymidylate synthase activity in colon tumor tissues after treatment with 5-fluorouracil.
Neoplasms
Development and Binding Mode Assessment of N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-?-glutamyl-d-glutamic Acid (BGC 945), a Novel Thymidylate Synthase Inhibitor That Targets Tumor Cells.
Neoplasms
Development of a novel thymidylate synthase (TS) inhibitor capable of up-regulating P53 expression and inhibiting angiogenesis in NSCLC.
Neoplasms
Development of an assay for the estimation of N10-propargyl-5,8-dideazafolic acid polyglutamates in tumor cells.
Neoplasms
DHFR/TYMS are positive regulators of glioma cell growth and modulate chemo-sensitivity to temozolomide.
Neoplasms
Dibutyltin(IV) complexes containing arylazobenzoate ligands: chemistry, in vitro cytotoxic effects on human tumor cell lines and mode of interaction with some enzymes.
Neoplasms
Difference in Ki67 and thymidylate synthase expression in primary tumour compared with metastatic nodes in breast cancer patients.
Neoplasms
Difference in thymidylate synthetase activity in involved nodes compared with primary tumor in breast cancer patients.
Neoplasms
Different expression of thymidylate synthase in primary tumour and metastatic nodes in breast cancer patients.
Neoplasms
Differential effects of two fluorouracil administration regimens for colorectal cancer.
Neoplasms
Differential expression and prognostic value of ERCC1 and thymidylate synthase in resected gastric adenocarcinoma.
Neoplasms
Differential oncogene amplification in tumor cells from a patient treated with cisplatin and 5-fluorouracil.
Neoplasms
Differentially potentiating effects by dipyridamole on cytotoxicity of 5-fluorouracil against three human maxillary cancer cell lines derived from a single tumor.
Neoplasms
Dihydrofluorouracil, a fluorouracil catabolite with antitumor activity in murine and human cells.
Neoplasms
Dihydropyrimidine Dehydrogenase 85T>C Mutation Is Associated With Ocular Toxicity of 5-Fluorouracil: A Case Report.
Neoplasms
Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice.
Neoplasms
Dihydropyrimidine dehydrogenase activity and thymidylate synthase level are associated with response to 5-fluorouracil in human colorectal cancer.
Neoplasms
Dihydropyrimidine dehydrogenase and messenger RNA levels in gastric cancer: possible predictor for sensitivity to 5-fluorouracil.
Neoplasms
Dihydropyrimidine dehydrogenase and orotate phosphoribosyltransferase in esophageal cancer patients: Correlation with clinicopathological factors and prognosis.
Neoplasms
Dihydropyrimidine dehydrogenase and thymidylate synthase activities in hepatocellular carcinomas and in diseased livers.
Neoplasms
Dihydropyrimidine dehydrogenase mRNA level correlates with the response to 5-fluorouracil-based chemo-immuno-radiation therapy in human oral squamous cell cancer.
Neoplasms
Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity.
Neoplasms
Discrepancies between the gene expression, protein expression, and enzymatic activity of thymidylate synthase and dihydropyrimidine dehydrogenase in human gastrointestinal cancers and adjacent normal mucosa.
Neoplasms
Dissociation of thymidylate biosynthesis from DNA biosynthesis by 5-fluoro-2'-deoxyuridine and 5,8-dideazaisofolic acid.
Neoplasms
Distribution of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase.
Neoplasms
Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine.
Neoplasms
Do the expression of CD44, apoptosis and thymidylate synthase inhibition rate correlate with the efficacy of chemotherapy in colorectal cancer?
Neoplasms
Does the primary site really matter? Profiling mucinous ovarian cancers of uncertain primary origin (MO-CUP) to personalise treatment and inform the design of clinical trials.
Neoplasms
Downregulation of TS, DPD, ERCC1, GST-Pi, EGFR, and HER2 gene expression after neoadjuvant three-modality treatment in patients with esophageal cancer.
Neoplasms
DPD is a molecular determinant of capecitabine efficacy in colorectal cancer.
Neoplasms
Drug-Repositioning Screens Identify Triamterene as a Selective Drug for the Treatment of DNA Mismatch Repair Deficient Cells.
Neoplasms
dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA-repair-defective human cancer cells.
Neoplasms
Dynamic modulation of thymidylate synthase gene expression and fluorouracil sensitivity in human colorectal cancer cells.
Neoplasms
E2F1 overexpression correlates with thymidylate synthase and survivin gene expressions and tumor proliferation in non small-cell lung cancer.
Neoplasms
Effect of a combined administration of 5-fluorouracil and medroxyprogesterone acetate on pyrimidine nucleoside phosphorylases and thymidylate synthetase in 7,12-dimethylbenz.
Neoplasms
Effect of altered thyroid status on lysosomal enzymes and thymidylate synthetase activity in tumors and livers of host animals.
Neoplasms
Effect of hammerhead ribozyme against human thymidylate synthase on the cytotoxicity of thymidylate synthase inhibitors.
Neoplasms
Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft.
Neoplasms
Effect of thymidylate synthase gene polymorphism on the response to chemotherapy and clinical outcome of non-small cell lung cancer patients.
Neoplasms
Effects of beta-carotene-rich algae Dunaliella bardawil on the dynamic changes of normal and neoplastic mammary cells and general metabolism in mice.
Neoplasms
Effects of Chinese herbal medicines on DNA-synthesizing enzyme activities in mammary tumors of mice.
Neoplasms
Effects of impaired renal function on the pharmacokinetics and toxicity of i.v. ZD9331, a novel non-polyglutamated thymidylate synthase inhibitor, in adult patients with solid tumors.
Neoplasms
Effects of intravesical instillation of 5-fluorouracil and interferon in patients with recurrent superficial urinary bladder carcinoma. A clinical and pharmacodynamic study.
Neoplasms
Effects of long-term administration of UFT plus leucovorin on colorectal tumors induced with 1,2-dimethylhydrazine in rats.
Neoplasms
Effects of lycopene on spontaneous mammary tumour development in SHN virgin mice.
Neoplasms
Effects of Mg2+ and adenine nucleotides on thymidylate synthetase from different mouse tumors.
Neoplasms
Effects of preoperative chemotherapy on gastric carcinoma: the relationship between histopathologic response and prognosis.
Neoplasms
Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma.
Neoplasms
Effects of tamoxifen on mammary tumors and bone in 7,12-dimethylbenz-(a)anthracene-treated rats.
Neoplasms
Effects of UFT (mixed compound of tegafur and uracil) on cell kinetics and inhibition of thymidylate synthase in L1210 ascites tumor.
Neoplasms
Effects of UFT on thymidylate synthase and dihydropyrimidine dehydrogenase activities in lung cancer.
Neoplasms
Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts.
Neoplasms
Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer.
Neoplasms
Efficacy of pemetrexed-based regimen in relapsed advanced thymic epithelial tumors and its association with thymidylate synthetase level.
Neoplasms
Efficacy of S-1 for patients with peritoneal metastasis of gastric cancer.
Neoplasms
Elevated levels of mRNAs encoding dihydropyrimidine dehydrogenase and thymidylate synthase are associated with improved survival of patients with hepatocellular carcinoma treated with S-1.
Neoplasms
Elevated levels of thymidylate synthase linked to neoplastic transformation of mammalian cells.
Neoplasms
Elevated Microsatellite Alterations at Selected Tetranucleotide Repeats (EMAST) and Microsatellite Instability in Patients with Colorectal Cancer and Its Clinical Features.
Neoplasms
Elevation of radiolabelled thymidine uptake in RIF-1 fibrosarcoma and HT29 colon adenocarcinoma cells after treatment with thymidylate synthase inhibitors.
Neoplasms
Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors.
Neoplasms
Emerging role of thymidylate synthase for the pharmacogenomic selection of patients with thoracic cancer.
Neoplasms
Enhanced expression of thymidylate synthase may be of prognostic importance in advanced cervical cancer.
Neoplasms
Enhanced expression of thymidylate synthase mediates resistance of uterine cervical cancer cells to radiation.
Neoplasms
Enhancement by thymidine of 5-fluorouracil's inhibition of thymidylate synthetase in human tumors.
Neoplasms
Enhancement of 5-Fluorouracil Cytotoxicity by Pyridoxal 5'-Phosphate and Folinic Acid in Tandem.
Neoplasms
Enhancement of the anti-tumor activity of S-1 by low-dose cisplatin in mice bearing the sarcoma-180 model.
Neoplasms
Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase.
Neoplasms
Epirubicin, cisplatin, and raltitrexed in patients with advanced gastric and hepatobiliary carcinoma: a phase II study.
Neoplasms
Epitope analysis and utility of monoclonal antibodies to native and recombinant human thymidylate synthase.
Neoplasms
ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates.
Neoplasms
ERCC1 mRNA levels and survival of advanced gastric cancer patients treated with a modified FOLFOX regimen.
Neoplasms
ERCC1 predicting chemoradiation resistance and poor outcome in oesophageal cancer.
Neoplasms
Establishment and characterization of novel xenograft models of human biliary tract carcinomas.
Neoplasms
Establishment of enzyme-linked immunosorbent assays for thymidylate synthase and dihydropyriminide dehydrogenase in cancer tissues.
Neoplasms
Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations.
Neoplasms
Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?
Neoplasms
Evaluating the role of ENOSF1 and TYMS variants as predictors in fluoropyrimidine-related toxicities: An IPD meta-analysis.
Neoplasms
Evaluation of 5-fluorouracil metabolic enzymes as predictors of response to adjuvant chemotherapy outcomes in patients with stage II/III colorectal cancer: a decision-curve analysis.
Neoplasms
Evaluation of effects of thymidylate synthase and excision repair cross-complementing 1 polymorphisms on chemotherapy outcome in patients with gastrointestinal tumors using peripheral venous blood.
Neoplasms
Evaluation of pemetrexed and etoposide as therapeutic regimens for human papillomavirus-positive oral and oropharyngeal cancer.
Neoplasms
Evaluation of Thymidylate Synthase Expression in Prostate Cancer.
Neoplasms
Evaluation of thymidylate synthase protein expression by Western blotting and immunohistochemistry on human colon carcinoma xenografts in nude mice.
Neoplasms
Evaluation of [(18)F]Fluorothymidine as a Biomarker for Early Therapy Response in a Mouse Model of Colorectal Cancer.
Neoplasms
Expression and prognostic significance of thymidylate synthase (TS) in pancreatic head and periampullary cancer.
Neoplasms
Expression of a molecular marker panel as a prognostic tool in gastric cancer patients treated postoperatively with docetaxel and irinotecan. A study of the Hellenic Cooperative Oncology Group.
Neoplasms
Expression of BRCA1, a factor closely associated with relapse-free survival, in patients who underwent neoadjuvant chemotherapy with docetaxel, cisplatin, and fluorouracil for squamous cell carcinoma of the esophagus.
Neoplasms
Expression of dihydropyrimidine dehydrogenase, thymidylate synthase, p53 and p21 in metastatic liver tumor from colorectal cancer after 5-fluorouracil-based chemotherapy.
Neoplasms
Expression of multidrug resistance-associated protein1,P-glycoprotein, and thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection.
Neoplasms
Expression of rTSbeta as a 5-fluorouracil resistance marker in patients with primary breast cancer.
Neoplasms
Expression of thymidylate synthase (TS) and its prognostic significance in patients with cutaneous angiosarcoma.
Neoplasms
Expression of thymidylate synthase in cancer of the ampulla of Vater.
Neoplasms
Expression of thymidylate synthase in human non-small cell lung cancer.
Neoplasms
Expression of thymidylate synthase in liver and lung metastases of colorectal cancer and their matched primary tumours.
Neoplasms
Expression of thymidylate synthase is correlated with proliferative activity in non-small cell lung cancer (NSCLC).
Neoplasms
Expression of thymidylate synthase, orotate phosphoribosyltransferase and dihydropyrimidine dehydrogenase in thymic epithelial tumors.
Neoplasms
Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition.
Neoplasms
Factors predicting the response to oral fluoropyrimidine drugs: a phase II trial on the individualization of postoperative adjuvant chemotherapy using oral fluorinated pyrimidines in stage III colorectal cancer treated by curative resection (ACT-01 Study).
Neoplasms
Failure of detection of the tyrosine to histidine substitution at the residue 33 of thymidylate synthase in human colorectal cancer. A preliminary study.
Neoplasms
Features of potentially predictive biomarkers of chemotherapeutic efficacy in small cell lung cancer.
Neoplasms
FGF2-FGFR1 pathway activation together with thymidylate synthase upregulation is induced in pemetrexed-resistant lung cancer cells.
Neoplasms
Fluorescence and computational studies of thymidine phosphorylase affinity toward lipidated 5-FU derivatives.
Neoplasms
Fluorodeoxyuridine Modulates Cellular Expression of the DNA Base Excision Repair Enzyme Uracil-DNA Glycosylase.
Neoplasms
Folate analogues. 21. Synthesis and antifolate and antitumor activities of N10-(cyanomethyl)-5,8-dideazafolic acid.
Neoplasms
Folate pathway genetic polymorphisms and susceptibility of central nervous system tumors in Thai children.
Neoplasms
Folate-based thymidylate synthase inhibitors in cancer chemotherapy.
Neoplasms
Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action.
Neoplasms
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting.
Neoplasms
Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS).
Neoplasms
Fuplatin: An Efficient and Low-Toxic Dual-Prodrug.
Neoplasms
Future potential of thymidylate synthase inhibitors in cancer therapy.
Neoplasms
G>C SNP of thymidylate synthase with respect to colorectal cancer.
Neoplasms
Gastric cancer with Virchow's and multiple lung metastases showing a remarkable response to preoperative chemotherapy: report of a case.
Neoplasms
Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3'-Deoxy-3'-[18F]Fluorothymidine in Preclinical Models of Lung Cancer.
Neoplasms
Gene dosage and expression, and enzyme activity of thymidine kinase and thymidylate synthase in xenografted colorectal adenocarcinomas.
Neoplasms
Gene expression of 5-fluorouracil metabolic enzymes in primary gastric cancer: correlation with drug sensitivity against 5-fluorouracil.
Neoplasms
Genes regulating the sensitivity of solid tumor cell lines to cytotoxic agents: a literature review.
Neoplasms
Genetic heterogeneity of variable number tandem repeats in thymidylate synthase gene in colorectal cancer patients.
Neoplasms
Genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase and risk of pancreatic cancer.
Neoplasms
Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapy.
Neoplasms
Genotoxicity of pemetrexed in human peripheral blood lymphocytes.
Neoplasms
Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts.
Neoplasms
Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study.
Neoplasms
Hepatic arterial infusion versus systemic therapy for hepatic metastases from colorectal cancer: a randomized trial of efficacy, quality of life, and molecular markers (CALGB 9481).
Neoplasms
Heterozygote deficiency in thymidylate synthase enhancer region polymorphism genotype distribution in Hungarian colorectal cancer patients.
Neoplasms
High gamma-glutamyl hydrolase and low folylpolyglutamate synthetase expression as prognostic biomarkers in patients with locally advanced gastric cancer who were administrated postoperative adjuvant chemotherapy with S-1.
Neoplasms
High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction.
Neoplasms
High pretherapeutic thymidylate synthetase and MRP-1 protein levels are associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patients.
Neoplasms
High-dose 5-Fluorouracil with uridine-diphosphoglucose rescue increases thymidylate synthase inhibition but not 5-Fluorouracil incorporation into RNA in murine tumors.
Neoplasms
High-grade and hormone-treated prostate cancer express high levels of thymidylate synthase.
Neoplasms
High-grade neuroendocrine carcinoma of the lung shows increased thymidylate synthase expression compared to other histotypes.
Neoplasms
High-level QM/MM calculations support the concerted mechanism for Michael addition and covalent complex formation in thymidylate synthase.
Neoplasms
Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells.
Neoplasms
Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells.
Neoplasms
Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.
Neoplasms
Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles.
Neoplasms
ICI D1694 and idoxuridine: a synergistic antitumor combination.
Neoplasms
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
Neoplasms
Identification of thymidylate synthase as a potential therapeutic target for lung cancer.
Neoplasms
Immunohistochemical analysis of thymidylate synthase expression in gastric carcinoma: correlation with clinicopathological parameters and survival.
Neoplasms
Immunohistochemical analysis of thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer (cUICC II/III): correlation with histopathologic tumor regression after 5-fluorouracil-based long-term neoadjuvant chemoradiotherapy.
Neoplasms
Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer.
Neoplasms
Immunohistochemistry Biomarkers Predict Survival in Stage II/III Gastric Cancer Patients: From a Prospective Clinical Trial.
Neoplasms
Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines.
Neoplasms
Impact of thymidylate synthase protein expression on efficacy of chemotherapy in advanced lung cancer patients.
Neoplasms
Impacts of fluorouracil-metabolizing enzymes on the outcomes of patients treated with S-1 alone or S-1 plus cisplatin for first-line treatment of advanced gastric cancer.
Neoplasms
Implication of the folate-methionine metabolism pathways in susceptibility to follicular lymphomas.
Neoplasms
In vitro and in vivo reversal of resistance to 5-fluorouracil in colorectal cancer cells with a novel stealth double-liposomal formulation.
Neoplasms
In vitro generation of cytotoxic T lymphocytes against HLA-A2.1-restricted peptides derived from human thymidylate synthase.
Neoplasms
In vitro selected peptides bind with thymidylate synthase mRNA and inhibit its translation.
Neoplasms
In vitro selection of an RNA sequence that interacts with high affinity with thymidylate synthase.
Neoplasms
In vitro uptake, anabolism, and cellular retention of 1843U89 and other benzoquinazoline inhibitors of thymidylate synthase.
Neoplasms
In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin.
Neoplasms
In vivo antitumor efficacy of CW252053, a folate-based thymidylate synthase inhibitor.
Neoplasms
Increased activities of thymidylate synthetase and thymidine kinase in human thyroid tumors.
Neoplasms
Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independent mechanisms.
Neoplasms
Increased levels of thymidylate synthetase in cells exposed to 5-fluorouracil.
Neoplasms
Increased thymidylate synthase gene expression in metastatic melanoma.
Neoplasms
Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells.
Neoplasms
Induction of cell cycle-dependent cytotoxicity and apoptosis by new heterodinucleoside phosphate dimers of 5-fluorodeoxyuridine in PC-3 human prostate cancer cells.
Neoplasms
Influence of dose of [6RS]leucovorin on reduced folate pools and 5-fluorouracil-mediated thymidylate synthase inhibition in human colon adenocarcinoma xenografts.
Neoplasms
Influence of thymidylate synthase and p53 protein expression on clinical outcome in patients with colorectal cancer.
Neoplasms
Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined "Complementary Lethality".
Neoplasms
Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction.
Neoplasms
Inhibition of mammalian tumour thymidylate synthetase by 2'-deoxyuridine 5'-phosphate analogues.
Neoplasms
Inhibition of mammalian tumour thymidylate synthetase by 5-alkylated 2'-deoxyuridine 5'-phosphates.
Neoplasms
Inhibition of mouse thymidylate synthase promoter activity by the wild-type p53 tumor suppressor protein.
Neoplasms
Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independent deletion of superantigen-reactive peripheral T cells.
Neoplasms
Inhibition of thymidylate synthase activity by antisense oligodeoxynucleotide and possible role in thymineless treatment.
Neoplasms
Inhibition of thymidylate synthase and cell growth by the phenanthroindolizidine alkaloids pergularinine and tylophorinidine.
Neoplasms
Inhibition of thymidylate synthase in intact L1210 cells by ara-C, daunomycin, hydroxyurea and 3,4-dihydroxybenzylamine.
Neoplasms
Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage.
Neoplasms
Inhibitory effect of lignin-related pine cone extract on cell proliferating enzyme activity of spontaneous mammary tumours in mice.
Neoplasms
Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance.
Neoplasms
Integrating Dynamic Positron Emission Tomography and Conventional Pharmacokinetic Studies to Delineate Plasma and Tumor Pharmacokinetics of FAU, a Prodrug Bioactivated by Thymidylate Synthase.
Neoplasms
Interaction between thymidylate synthase and its cognate mRNA in zebrafish embryos.
Neoplasms
Interaction of 5-fluoro-4-thio-2'-deoxyuridine 5'-phosphate with mammalian tumour thymidylate synthase: role of the pyrimidine N(3)-H dissociation.
Neoplasms
Interferon alpha-2a shows antitumor activity in combination with 5-fluorouracil against human colon carcinoma xenografts: a study in reference to thymidylate synthetase activity inhibition.
Neoplasms
Interferons as biomodulators of fluoropyrimidines in the treatment of colorectal cancer.
Neoplasms
Interleukin-2 as a modulator of 5-fluorouracil in hepatic arterial immunochemotherapy for liver metastases.
Neoplasms
Intratumor dihydropyrimidine dehydrogenase mRNA expression levels are decreased in extramammary Paget's disease.
Neoplasms
Intratumoural thymidylate synthase and dihydropyrimidine dehydrogenase activities are good predictors of 5-fluorouracil sensitivity in colorectal cancer.
Neoplasms
Irinotecan overcomes the resistance to 5-fluorouracil in human colon cancer xenografts by down-regulation of intratumoral thymidylate synthase.
Neoplasms
Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells.
Neoplasms
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
Neoplasms
Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase.
Neoplasms
Kinetic properties of human thymidylate synthase, an anticancer drug target.
Neoplasms
Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapy.
Neoplasms
Lapatinib, a dual EGFR and HER2 tyrosine kinase inhibitor, downregulates thymidylate synthase by inhibiting the nuclear translocation of EGFR and HER2.
Neoplasms
Leucovorin and folic acid regimens for selective expansion of murine 5,10-methylenetetrahydrofolate pools.
Neoplasms
Leucovorin rescue from raltitrexed (tomudex)-induced antiproliferative effects: in vitro cell line and in vivo mouse studies.
Neoplasms
Logistic regression model of the clinical response to 5-fluorouracil based chemotherapy for metastatic colorectal cancer patients.
Neoplasms
Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene.
Neoplasms
Loss of Uracil DNA Glycosylase Selectively Resensitizes p53-Mutant and -Deficient Cells to 5-FdU.
Neoplasms
Low thymidylate synthase expression in the primary tumor predicts favorable clinical outcome in resected gastric cancer patients treated with adjuvant tegafur.
Neoplasms
Mechanism of action of key enzymes associated with cancer propagation and their inhibition by various chemotherapeutic agents.
Neoplasms
Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus.
Neoplasms
Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability.
Neoplasms
Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil.
Neoplasms
Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.
Neoplasms
Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition.
Neoplasms
Microarray analysis reveals down-regulation of the tumour suppressor gene WWOX and up-regulation of the oncogene TYMS in intracranial sporadic meningiomas.
Neoplasms
MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cells.
Neoplasms
MicroRNAs and colorectal cancer chemoresistance: New solution for old problem.
Neoplasms
Microsatellite instability and the association with plasma homocysteine and thymidylate synthase in colorectal cancer.
Neoplasms
Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expression.
Neoplasms
miR-192, miR-194 and miR-215: a convergent microRNA network suppressing tumor progression in renal cell carcinoma.
Neoplasms
miR-192/miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase regulation.
Neoplasms
Modulation by l-leucovorin of 1-hexylcarbamoyl-5-fluorouracil antitumor activity on human gastric and colon carcinomas serially transplanted into nude mice.
Neoplasms
Modulation of 5-fluoro-2'-deoxyuridine response by folinic acid in human colonic tumor cell lines: the role of thymidylate synthase.
Neoplasms
Modulation of 5-fluorouracil resistance in human colon tumor cell lines by azidothymidine.
Neoplasms
Modulation of [5-125I]iododeoxyuridine incorporation into tumour and normal tissue DNA by methotrexate and thymidylate synthase inhibitors.
Neoplasms
Molecular and Dynamic Evaluation of Proteins Related to Resistance to Neoadjuvant Treatment with Chemoradiotherapy in Circulating Tumor Cells of Patients with Locally Advanced Rectal Cancer.
Neoplasms
Molecular basis of the interaction of novel tributyltin(IV) 2/4-[(E)-2-(aryl)-1-diazenyl]benzoates endowed with an improved cytotoxic profile: synthesis, structure, biological efficacy and QSAR studies.
Neoplasms
Molecular factors of 5-fluorouracil metabolism in colorectal cancer: analysis of primary tumor and lymph node metastasis.
Neoplasms
Molecular markers and prediction of response to chemoradiation in rectal cancer.
Neoplasms
Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells.
Neoplasms
Molecular prognostic markers in resectable colorectal liver metastases: a systematic review.
Neoplasms
MTHFR (C677T) polymorphisms and stage III colon cancer: response to therapy.
Neoplasms
Multi-level gene expression profiles affected by thymidylate synthase and 5-FU in colon cancer.
Neoplasms
Multiaction Platinum(IV) Prodrug Containing Thymidylate Synthase Inhibitor and Metabolic Modifier against Triple-Negative Breast Cancer.
Neoplasms
Multidrug resistance and its reversal.
Neoplasms
Multidrug Resistance in Primary Tumors and Metastases in Patients with Esophageal Squamous Cell Carcinoma.
Neoplasms
Multiple molecular alterations in mouse lung tumors.
Neoplasms
Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.
Neoplasms
Nab-Paclitaxel Plus S-1 Shows Increased Antitumor Activity in Patient-Derived Pancreatic Cancer Xenograft Mouse Models.
Neoplasms
NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint.
Neoplasms
New agents for colon and breast cancer.
Neoplasms
New developments in cancer treatment with the novel thymidylate synthase inhibitor raltitrexed ('Tomudex').
Neoplasms
New drugs for patients with pancreatic cancer.
Neoplasms
New Insight into the Octamer of TYMS Stabilized by Intermolecular Cys43-Disulfide.
Neoplasms
New targets for pyrimidine antimetabolites in the treatment of solid tumours. 1: Thymidylate synthase.
Neoplasms
Nonpolyglutamatable antifolates as inhibitors of thymidylate synthase (TS) and potential antitumour agents.
Neoplasms
Novel chemical strategies for thymidylate synthase inhibition.
Neoplasms
Novel combinations with oxaliplatin.
Neoplasms
Novel thymidylate synthase enhancer region alleles in African populations.
Neoplasms
Nuclear thymidylate synthase expression in sporadic colorectal cancer depends on the site of the tumor.
Neoplasms
Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011.
Neoplasms
Nucleotide biosynthesis arrest by silencing SHMT1 function via vitamin B6-coupled vector and effects on tumor growth inhibition.
Neoplasms
ODN 491, a novel antisense oligodeoxynucleotide that targets thymidylate synthase, exerts cell-specific effects in human tumor cell lines.
Neoplasms
Overexpression of E2F-1 in lung and liver metastases of human colon cancer is associated with gene amplification.
Neoplasms
Overexpression of thymidylate synthase (TYMS) is associated with aggressive tumor features and early PSA recurrence in prostate cancer.
Neoplasms
Overexpression of thymidylate synthase mediates desensitization for 5-fluorouracil of tumor cells.
Neoplasms
Overview: rational basis for development of fluoropyrimidine/5-formyltetrahydrofolate combination chemotherapy.
Neoplasms
p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site.
Neoplasms
p53, DCC and thymidylate synthase as predictors of survival after resection of hepatic metastases from colorectal cancer.
Neoplasms
p53, deleted in colorectal cancer gene, and thymidylate synthase as predictors of histopathologic response and survival in low, locally advanced rectal cancer treated with preoperative adjuvant therapy.
Neoplasms
Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools.
Neoplasms
Parenteral nutrition decreases hepatic dihydropyrimidine dehydrogenase activity and modulates catabolism of 5-fluorouracil in rats.
Neoplasms
Pathological complete response after neoadjuvant therapy for rectal cancer and the role of adjuvant therapy.
Neoplasms
PD-L1 expression indicates favorable prognosis for advanced lung adenocarcinoma patients treated with pemetrexed.
Neoplasms
Pemetrexed disodium (Eli Lilly).
Neoplasms
Pemetrexed for diffuse malignant pleural mesothelioma.
Neoplasms
Pemetrexed: an active new agent for breast cancer.
Neoplasms
pH-Promoted Release of a Novel Anti-Tumour Peptide by "Stealth" Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells.
Neoplasms
Pharmacogenomics of thymidylate synthase in cancer treatment.
Neoplasms
Pharmacokinetic and Pharmacodynamic Analyses of 5-Fluorouracil in East-Asian Patients with Nasopharyngeal Carcinoma.
Neoplasms
Pharmacokinetic/pharmacodynamic study of ZD9331, a nonpolyglutamatable inhibitor of thymidylate synthase, in a murine model following two curative administration schedules.
Neoplasms
Pharmacological and toxicological evaluation of a new series of thymidylate synthase inhibitors as anticancer agents.
Neoplasms
Phase 2 study of treatment selection based on tumor thymidylate synthase expression in previously untreated patients with metastatic colorectal cancer: A trial of the ECOG-ACRIN Cancer Research Group (E4203).
Neoplasms
Phase I and pharmacologic study of oral ZD9331, a novel nonpolyglutamated thymidylate synthase inhibitor, in adult patients with solid tumors.
Neoplasms
Phase I study of AG 331, a novel thymidylate synthase inhibitor, in patients with refractory solid tumors.
Neoplasms
Phase I study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor in patients with refractory solid tumors.
Neoplasms
Phase I trial of the thymidylate synthase inhibitor AG331 as a 5-day continuous infusion.
Neoplasms
Phase I trial of thymidylate synthase poly-epitope peptide (TSPP) vaccine in advanced cancer patients.
Neoplasms
Phase I trial of UFT/leucovorin and irinotecan in patients with advanced cancer.
Neoplasms
Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors.
Neoplasms
Phase I trial of ZD9331, a nonpolyglutamatable thymidylate synthase inhibitor, given as a 5-day continuous infusion to patients with refractory solid malignancies.
Neoplasms
Phase I, pharmacokinetic and biological correlative study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor, and cisplatin in patients with solid tumors.
Neoplasms
Phase II clinical trial of capecitabine in ovarian carcinoma recurrent 6-12 months after completion of primary chemotherapy, with exploratory TS, DPD, and TP correlates: a Gynecologic Oncology Group study.
Neoplasms
Phase II multicentre trial of ZD9331 monotherapy as first-line treatment for gastric cancer.
Neoplasms
Phase II Study of Pemetrexed and Cisplatin, with Chest Radiotherapy Followed by Docetaxel in Patients with Stage III Non-small Cell Lung Cancer.
Neoplasms
Phase II study of weekly intravenous oxaliplatin combined with oral daily capecitabine and radiotherapy with biologic correlates in neoadjuvant treatment of rectal adenocarcinoma.
Neoplasms
Plasma thymidylate synthase and dihydrofolate reductase mRNA levels as potential predictive biomarkers of pemetrexed sensitivity in patients with advanced non-small cell lung cancer.
Neoplasms
Polymorphism in the thymidylate synthase promoter enhancer region is not an efficacious marker for tumor sensitivity to 5-fluorouracil-based oral adjuvant chemotherapy in colorectal cancer.
Neoplasms
Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.
Neoplasms
Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis.
Neoplasms
Polymorphisms of Folate Pathway Enzymes (Methylenetetrahydrofolate Reductase and Thymidylate Synthase) and Their Relationship with Thymidylate Synthase Expression in Human Astrocytic Tumors.
Neoplasms
Population study of expression of thymidylate synthase and dihydropyrimidine dehydrogenase in patients with solid tumors.
Neoplasms
Positive Cooperativity in Substrate Binding by Human Thymidylate Synthase.
Neoplasms
Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent.
Neoplasms
Preclinical and phase I clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors.
Neoplasms
Preclinical pharmacology of CB30900, a novel dipeptide inhibitor of thymidylate synthase, in mice.
Neoplasms
Prediction of sensitivity to fluoropyrimidines by metabolic and target enzyme activities in gastric cancer.
Neoplasms
Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO study.
Neoplasms
Predictive and Prognostic Value of 18F-fluorodeoxyglucose Uptake Combined with Thymidylate Synthase Expression in Patients with Advanced Non-Small Cell Lung Cancer.
Neoplasms
Predictive molecular markers for colorectal cancer patients with resected liver metastasis and adjuvant chemotherapy.
Neoplasms
Predictive value of Ki67 and p53 in locally advanced rectal cancer: correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy.
Neoplasms
Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase expression in tumor tissue, regarding the efficacy of postoperatively administered UFT (tegafur+uracil) in patients with non-small cell lung cancer.
Neoplasms
Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients.
Neoplasms
Predictive value of thymidylate synthase expression in gastric cancer: a systematic review with meta-analysis.
Neoplasms
Predictors of response and survival for neoadjuvant treated patients with esophageal adenocarcinoma.
Neoplasms
Preferential tumor targeting and selective tumor cell cytotoxicity of 5-[131/125I]iodo-4'-thio-2'-deoxyuridine.
Neoplasms
Preparation of the antibodies against recombinant human thymidylate synthase for the detection of its intratumoral levels and the application to sensitivity-study of 5-fluorouracil.
Neoplasms
Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein.
Neoplasms
Prodrugs of thymidylate synthase inhibitors: potential for antibody directed enzyme prodrug therapy (ADEPT).
Neoplasms
Prognostic and predictive factors in colorectal cancer.
Neoplasms
Prognostic and predictive molecular markers in colorectal carcinoma.
Neoplasms
Prognostic of DNA-synthesizing enzyme activities (thymidine kinase and thymidylate synthase) in 908 T1-T2, N0-N1, M0 breast cancers: a retrospective multicenter study.
Neoplasms
Prognostic significance of 5-fluorouracil metabolism-relating enzymes and enhanced chemosensitivity to 5-fluorouracil by 5-chloro 2,4-dihydroxy-pyridine in urothelial carcinoma.
Neoplasms
Prognostic Significance of miR-215 in Colon Cancer.
Neoplasms
Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors.
Neoplasms
Prognostic significance of thymidylate synthase (TS) expression in cutaneous malignant melanoma.
Neoplasms
Prognostic significance of thymidylate synthase expression in patients with prostate cancer undergoing radical prostatectomy.
Neoplasms
Prognostic significance of thymidylate synthase in patients with metastatic colorectal cancer who receive protracted venous infusions of 5-fluorouracil.
Neoplasms
Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy.
Neoplasms
Prognostic significance of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in biliary tract cancer patients receiving adjuvant 5-fluorouracil-based chemotherapy.
Neoplasms
Prognostic value of histologic tumor regression, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer UICC Stage II/III after neoadjuvant chemoradiotherapy.
Neoplasms
Prognostic value of thymidylate synthase expression in patients with p-stage I adenocarcinoma of the lung.
Neoplasms
Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study.
Neoplasms
Proliferation-dependent cytotoxicity of methotrexate in murine L5178Y leukemia.
Neoplasms
Protein Expression Profiles Indicative for Drug Resistance of Kidney Carcinoma.
Neoplasms
Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase.
Neoplasms
PTEN, tau-AP-3, thymidylate synthase immunohistochemistry scoring expression in patients with uterine leiomyomas, uterine smooth muscle tumors of uncertain malignancy potential and uterine leiomyosarcomas.
Neoplasms
Purification and characterization of thymidylate synthetase in the liver of the mouse bearing Ehrlich ascites tumor.
Neoplasms
Purification and properties of mouse thymus thymidylate synthase. Comparison of the enzyme from mammalian normal and tumour tissues.
Neoplasms
Purification of mammalian tumor (L1210) thymidylate synthetase by affinity chromatography on stable biospecific adsorbent. Stabilization of the enzyme with neutral detergents.
Neoplasms
Pyrimidine nucleotide metabolism in human colon carcinomas: comparison of normal tissues, primary tumors and xenografts.
Neoplasms
Quantitation of thymidylate synthase in human tumors using an ultrasensitive enzyme-linked immunoassay.
Neoplasms
Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction.
Neoplasms
Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation.
Neoplasms
Randomized clinical trial of adjuvant chemotherapy with S-1 versus gemcitabine after pancreatic cancer resection.
Neoplasms
Rapid detection of thymidylate synthase gene expression levels by semi-quantitative competitive reverse transcriptase polymerase chain reaction followed by quantitative digital image analysis.
Neoplasms
Rapid quantitation of plasma 2'-deoxyuridine by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry and its application to pharmacodynamic studies in cancer patients.
Neoplasms
Real-time RT-PCR (TaqMan) of tumor mRNA to predict sensitivity of specimens to 5-fluorouracil.
Neoplasms
Recent advances in the study of rTS proteins. rTS expression during growth and in response to thymidylate synthase inhibitors in human tumor cells.
Neoplasms
Recombinant human interferon alpha-2a increases 5-fluorouracil efficacy by elevating fluorouridine concentration in tumor tissue.
Neoplasms
Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography.
Neoplasms
Relationship between 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthase activity subsequent to 5-fluorouracil administration, in xenografts of human colon adenocarcinomas.
Neoplasms
Relationship between expression of 5-fluorouracil metabolic enzymes and 5-fluorouracil sensitivity in esophageal carcinoma cell lines.
Neoplasms
Relationships between resistance to cisplatin and antifolates in sensitive and resistant tumour cell lines.
Neoplasms
Relative activities of thymidylate synthetase and thymidine kinase in human mammary tumours.
Neoplasms
Relative activities of thymidylate synthetase and thymidine kinase in rat tissues.
Neoplasms
Relative level of thymidylate synthase mRNA expression in primary tumors and normal tissues predicts survival of patients with oral tongue squamous cell carcinoma.
Neoplasms
Resistance proteins in human kidney, breast, ovarian and lung-carcinoma - a comparative-analysis.
Neoplasms
Response prediction in metastasised colorectal cancer using intratumoural thymidylate synthase: Results of a randomised multicentre trial.
Neoplasms
Retrospective study on thymidylate synthase as a predictor of outcome and sensitivity to adjuvant chemotherapy in patients with curatively resected colorectal cancer.
Neoplasms
Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation.
Neoplasms
Role of biological markers in the clinical outcome of colon cancer.
Neoplasms
Role of dihydropyrimidine dehydrogenase and thymidylate synthase expression in immunohistochemistry of intrahepatic cholangiocarcinoma.
Neoplasms
Role of E2F-1 in chemosensitivity.
Neoplasms
Roles of thymidylate synthase and dihydropyrimidine dehydrogenase expression in blood as predictors of response to multimodal therapy in esophageal cancer.
Neoplasms
Roles of thymidylate synthase and dihydropyrimidine dehydrogenase in tumor progression and sensitivity to 5-fluorouracil in human gastric cancer.
Neoplasms
Schedule dependent inhibition of thymidylate synthase and tumor growth by 5-fluorouracil in Yoshida sarcoma bearing rats.
Neoplasms
Schedule-dependent synergism and antagonism between raltitrexed ("Tomudex") and methotrexate in human colon cancer cell lines in vitro.
Neoplasms
Second-look hepatectomy after 5FU arterial infusion in patients with primary unresectable hepatic colorectal metastases.
Neoplasms
Selective activation of 5'-deoxy-5-fluorouridine by tumor cells as a basis for an improved therapeutic index.
Neoplasms
Selective delivery of CB300638, a cyclopenta[g]quinazoline-based thymidylate synthase inhibitor into human tumor cell lines overexpressing the alpha-isoform of the folate receptor.
Neoplasms
Selective expansion of 5,10-methylenetetrahydrofolate pools and modulation of 5-fluorouracil antitumor activity by leucovorin in vivo.
Neoplasms
Selective incorporation of iododeoxyuridine into DNA of hepatic metastases versus normal human liver.
Neoplasms
Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin.
Neoplasms
Sequential inhibitory effects of antitumor agents related to levodopa and dopamine upon DNA synthetic enzymes.
Neoplasms
Significance of Differential Expression of Thymidylate Synthase in Normal and Primary Tumor Tissues from Patients with Colorectal Cancer.
Neoplasms
Significant increase in risk of gastroesophageal cancer is associated with interaction between promoter polymorphisms in thymidylate synthase and serum folate status.
Neoplasms
Single amino acid substitution defines a naturally occurring genetic variant of human thymidylate synthase.
Neoplasms
siRNA knockdown of mitochondrial thymidine kinase 2 (TK2) sensitizes human tumor cells to gemcitabine.
Neoplasms
Site-directed ligand discovery.
Neoplasms
Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition.
Neoplasms
Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase.
Neoplasms
Standing the test of time: targeting thymidylate biosynthesis in cancer therapy.
Neoplasms
Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.
Neoplasms
Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations.
Neoplasms
Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase.
Neoplasms
Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.
Neoplasms
Structure of human thymidylate synthase under low-salt conditions.
Neoplasms
Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding.
Neoplasms
Studies on resistance against 5-fluorouracil. II. Thymidylate synthetase from drug-resistant tumor lines.
Neoplasms
Substituted pyrrolo[2,3-d]pyrimidines as Cryptosporidium hominis thymidylate synthase inhibitors.
Neoplasms
Suicide prodrugs activated by thymidylate synthase: rationale for treatment and noninvasive imaging of tumors with deoxyuridine analogues.
Neoplasms
Superior antimetastatic effect of pemetrexed-loaded gelatinase-responsive nanoparticles in a mouse metastasis model.
Neoplasms
Suppression by coffee cherry of the growth of spontaneous mammary tumours in SHN mice.
Neoplasms
Suppressive effect of TNF-alpha on increased production of FdUMP by IFN-alpha.
Neoplasms
Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of gefitinib-induced down-regulation of thymidylate synthase.
Neoplasms
Synthesis and evaluation of new salicylaldehyde-2-picolinylhydrazone Schiff base compounds of Ru(II), Rh(III) and Ir(III) as in vitro antitumor, antibacterial and fluorescence imaging agents.
Neoplasms
Synthesis and interaction with thymidylate synthase of 5'-dithiophosphate and 5'-fluorothiophosphate of thymidine.
Neoplasms
Synthesis of New 1, 3, 4-Oxadiazole-Incorporated 1, 2, 3-Triazole Moieties as Potential Anticancer Agents Targeting Thymidylate Synthase and Their Docking Studies.
Neoplasms
Synthetic inhibitors of Escherichia coli, calf thymus, and Ehrlich ascites tumor thymidylate synthetase.
Neoplasms
Systematic Review of Candidate Single-nucleotide Polymorphisms as Biomarkers for Responsiveness to Neoadjuvant Chemoradiation for Rectal Cancer.
Neoplasms
Tailor-made chemotherapy for non-small cell lung cancer patients.
Neoplasms
Targeting nucleotide metabolism enhances the efficacy of anthracyclines and anti-metabolites in triple-negative breast cancer.
Neoplasms
Targeting the alpha-folate receptor with cyclopenta[g]quinazoline-based inhibitors of thymidylate synthase.
Neoplasms
Ternary complex formation and reduced folate in surgical specimens of human adenocarcinoma tissues.
Neoplasms
The ability of hypoxia to modify the gene expression of thymidylate synthase in tumour cells in vivo.
Neoplasms
The cytotoxicity of 5-fluorouracil is due to its incorporation into RNA not its inhibition of thymidylate synthase as evidenced by the use of a mouse cell mutant deficient in thymidylate synthase.
Neoplasms
The effect of different routes of administration of 5-fluorouracil on thymidylate synthase inhibition in the rat.
Neoplasms
The effect of dose and interval between 5-fluorouracil and leucovorin on the formation of thymidylate synthase ternary complex in human cancer cells.
Neoplasms
The efficacy of pemetrexed as a third- or fourth-line therapy and the significance of thymidylate synthase expression in patients with advanced non-small cell lung cancer.
Neoplasms
The ERK-ZEB1 pathway mediates epithelial-mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids.
Neoplasms
The impact of surgically induced ischaemia on protein levels in patients undergoing rectal cancer surgery.
Neoplasms
The interaction of thymidylate synthase expression with p53-regulated signaling pathways in tumor cells.
Neoplasms
The means to an end of tumor cell resistance to chemotherapeutic drugs targeting thymidylate synthase: shoot the messenger.
Neoplasms
The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine.
Neoplasms
The place of pemetrexed in the management of non-small-cell lung cancer patients.
Neoplasms
The potentiation of radiation response in human colon carcinoma cells in vitro and murine lymphoma in vivo by AG337 (Thymitaq), a novel thymidylate synthase inhibitor.
Neoplasms
The presence of three repeats in the 5' UTR region of thymidylate synthase (TS) is associated with increased TS mRNA expression in cultured human cancer cell lines in vitro.
Neoplasms
The prognostic significance of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in breast carcinomas.
Neoplasms
The Role of Dihydropyrimidine Dehydrogenase and Thymidylate Synthase Polymorphisms in Fluoropyrimidine-Based Cancer Chemotherapy in an Iranian Population.
Neoplasms
The role of interferon-alpha as a modulator of fluorouracil and leucovorin.
Neoplasms
The role of p-glycoprotein, glutathione-s-transferase-pi, thymidylate synthase and metallothionein in the expression of differential sensitivities to antitumor agents in human tumor xenografts.
Neoplasms
The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer.
Neoplasms
The role of thymidylate synthase in cellular regulation.
Neoplasms
The role of thymidylate synthetase inhibitors in bromodeoxyuridine-induced neoplasia in Drosophila.
Neoplasms
Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model.
Neoplasms
Therapeutic enhancement of S-1 with CPT-11 through down-regulation of thymidylate synthase in bladder cancer.
Neoplasms
Third International Conference on Biology, Prevention and Treatment of Gastrointestinal Malignancies. Cologne, 23-26 September 1998.
Neoplasms
Three-dimensional structure of the R115E mutant of T4-bacteriophage 2'-deoxycytidylate deaminase.
Neoplasms
Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen.
Neoplasms
Thymidine phosphorylase affects clinical outcome following surgery and mRNA expression levels of four key enzymes for 5-fluorouracil metabolism in patients with stage I and II non-small cell lung cancer.
Neoplasms
Thymidine phosphorylase expression in metastatic sites is predictive for response in patients with colorectal cancer treated with continuous oral capecitabine and biweekly oxaliplatin.
Neoplasms
Thymidine phosphorylase moderates thymidine-dependent rescue after exposure to the thymidylate synthase inhibitor ZD1694 (Tomudex) in vitro.
Neoplasms
Thymidine phosphorylase mRNA level predicts survival of patients with advanced oropharyngeal cancer.
Neoplasms
Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors-correlation to tumor histopathology and clinical follow-up.
Neoplasms
Thymidine phosphorylase: its role in sensitivity and resistance to anticancer drugs.
Neoplasms
Thymidylate synthase (TS) and ribonucleotide reductase (RNR) may be involved in acquired resistance to 5-fluorouracil (5-FU) in human cancer xenografts in vivo.
Neoplasms
Thymidylate synthase (TS) mRNA levels in plasma and tumor as potential predictive biomarkers for raltitrexed sensitivity in gastric cancer.
Neoplasms
Thymidylate synthase activity as a prognostic factor in ovarian cancer.
Neoplasms
Thymidylate synthase activity in leukocytes from patients with chronic myelocytic leukemia and acute lymphocytic leukemia and its inhibition by phenanthroindolizidine alkaloids pergularinine and tylophorinidine.
Neoplasms
Thymidylate synthase activity, folates, and glutathione system in head and neck carcinoma and adjacent tissues.
Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase activities in non-small cell lung cancer tissues: relationship with in vitro sensitivity to 5-fluorouracil.
Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase are upregulated in pancreatic and biliary tract cancers.
Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase expression levels are associated with response to S-1 plus carboplatin in advanced non-small cell lung cancer.
Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in relation to differentiation of gastric cancer.
Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase in non-small cell lung cancer: relationship between mRNA expression and activity.
Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5-fluorouracil to patients with colorectal cancer.
Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in thymoma.
Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in tumor tissues and the efficacy of 5-fluorouracil in patients with non-small-cell lung cancer.
Neoplasms
Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity.
Neoplasms
Thymidylate synthase and p53 expression in primary tumor do not predict chemotherapy outcome in metastatic colorectal carcinoma.
Neoplasms
Thymidylate synthase as a determinant of 5-fluoro-2'-deoxyuridine response in human colonic tumor cell lines.
Neoplasms
Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer.
Neoplasms
Thymidylate synthase as a molecular target for drug discovery using the National Cancer Institute's Anticancer Drug Screen.
Neoplasms
Thymidylate synthase as a target in cancer chemotherapy.
Neoplasms
Thymidylate synthase as an oncogene?
Neoplasms
Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy.
Neoplasms
Thymidylate synthase expression and activity: relation to S-phase parameters and 5-fluorouracil sensitivity.
Neoplasms
Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung.
Neoplasms
Thymidylate synthase expression as a predictive biomarker of pemetrexed sensitivity in advanced non-small cell lung cancer.
Neoplasms
Thymidylate synthase expression as a predictor of the prognosis of curatively resected colon carcinoma in patients registered in an adjuvant immunochemotherapy clinical trial.
Neoplasms
Thymidylate synthase expression at metastatic site might be more correlated with response to anti-thymidylate synthase agent in triple negative breast cancers.
Neoplasms
Thymidylate synthase expression determines pemetrexed targets and resistance development in tumour cells.
Neoplasms
Thymidylate synthase expression in circulating tumor cells: A new tool to predict 5-fluorouracil resistance in metastatic colorectal cancer patients.
Neoplasms
Thymidylate synthase expression in gastroenteropancreatic and pulmonary neuroendocrine tumors.
Neoplasms
Thymidylate synthase expression in hepatic tumors is a predictor of survival and progression in patients with resectable metastatic colorectal cancer.
Neoplasms
Thymidylate synthase expression levels: a prognostic and predictive role in advanced colorectal cancer.
Neoplasms
Thymidylate synthase expression, p53, bcl-2, Ki-67 and p27 in colorectal cancer: relationships with tumor recurrence and survival.
Neoplasms
Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy.
Neoplasms
Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.
Neoplasms
Thymidylate synthase gene expression in primary tumors predicts activity of s-1-based chemotherapy for advanced gastric cancer.
Neoplasms
Thymidylate synthase gene of herpesvirus ateles.
Neoplasms
Thymidylate Synthase Gene Polymorphism Affects the Response to Preoperative 5-Fluorouracil Chemoradiation Therapy in Patients With Rectal Cancer.
Neoplasms
Thymidylate synthase gene polymorphisms as important contributors affecting hepatocellular carcinoma prognosis.
Neoplasms
Thymidylate synthase gene variations: predictive and prognostic markers.
Neoplasms
Thymidylate synthase genetic polymorphisms and cancer risk: a meta-analysis of 37 case-control studies.
Neoplasms
Thymidylate synthase genotype-directed chemotherapy for patients with gastric and gastroesophageal junction cancers.
Neoplasms
Thymidylate synthase genotype-directed neoadjuvant chemoradiation for patients with rectal adenocarcinoma.
Neoplasms
Thymidylate synthase genotypes and tumour regression in stage II/III rectal cancer patients after neoadjuvant fluorouracil-based chemoradiation.
Neoplasms
Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer.
Neoplasms
Thymidylate synthase in advanced gastrointestinal and breast cancers.
Neoplasms
Thymidylate synthase in normal and cancer tissues.
Neoplasms
Thymidylate synthase inhibition as a predictor of tumor sensitivity of fluorinated pyrimidines.
Neoplasms
Thymidylate synthase inhibitors for non-small cell lung cancer.
Neoplasms
Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors.
Neoplasms
Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial-to-mesenchymal transition of cancer cells.
Neoplasms
Thymidylate synthase levels in tumor biopsies from patients with colorectal cancer.
Neoplasms
Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers.
Neoplasms
Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival.
Neoplasms
Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival.
Neoplasms
Thymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis.
Neoplasms
Thymidylate synthase polymorphisms and hematological cancer risk: evidence needs further clarification.
Neoplasms
Thymidylate synthase polymorphisms, folate and B-vitamin intake, and risk of colorectal adenoma.
Neoplasms
Thymidylate synthase protein and p53 mRNA form an in vivo ribonucleoprotein complex.
Neoplasms
Thymidylate Synthase Protein Expression
Neoplasms
Thymidylate synthase protein expression and activity are related to the cell proliferation rate in human cancer cell lines.
Neoplasms
Thymidylate synthase protein expression in primary colorectal cancer: lack of correlation with outcome and response to fluorouracil in metastatic disease sites.
Neoplasms
Thymidylate synthase quantitation and in vitro chemosensitivity testing predicts responses and survival of patients with isolated nonresectable liver tumors receiving hepatic arterial infusion chemotherapy.
Neoplasms
Thymidylate synthase structure, function and implication in drug discovery.
Neoplasms
Thymidylate synthase was associated with patient prognosis and the response to adjuvant therapy in bladder cancer.
Neoplasms
Thymidylate Synthase, a New Myoepithelial Biomarker for Breast Lesions.
Neoplasms
Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine.
Neoplasms
Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis.
Neoplasms
Thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase expression, and histological tumour regression after 5-FU-based neo-adjuvant chemoradiotherapy in rectal cancer.
Neoplasms
Thymidylate synthase: a critical target for cancer chemotherapy.
Neoplasms
Thymidylate synthase: a critical target in cancer therapy?
Neoplasms
Thymidylate synthetase - a target enzyme in cancer chemotherapy.
Neoplasms
Thymidylate synthetase activity and fluorouracil sensitivity of human colonic cancer and normal mucosal tissue preparations.
Neoplasms
Thymidylate synthetase and dihydropyrimidine dehydrogenase levels in gastric cancer.
Neoplasms
Thymidylate synthetase and thymidine kinase activities and methotrexate cytotoxicity during growth of L1210 and Ehrlich ascites tumor.
Neoplasms
Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil.
Neoplasms
Thymidylate synthetase inhibitors. Synthesis of N-substituted 5-aminomethyl-2'-deoxyuridine 5'-phosphates.
Neoplasms
Thymidylate synthetase levels as a factor in 5-fluorodeoxyuridine and methotrexate cytotoxicity in gastrointestinal tumor cells.
Neoplasms
Topoisomerase 2? and thymidylate synthase expression in adrenocortical cancer.
Neoplasms
Topoisomerase I expression is associated with prognosis in postoperative non-small cell lung cancer patients.
Neoplasms
Topoisomerase-I, thymidylate synthase primary tumour expression and clinical efficacy of 5-FU/CPT-11 chemotherapy in advanced colorectal cancer patients.
Neoplasms
Transgenic expression of human thymidylate synthase accelerates the development of hyperplasia and tumors in the endocrine pancreas.
Neoplasms
Translational research with pemetrexed in breast cancer.
Neoplasms
Treatment of SW620 cells with Tomudex and oxaliplatin induces changes in 2-deoxy-D-glucose incorporation associated with modifications in glucose transport.
Neoplasms
TS and ERCC-1 mRNA expressions and clinical outcome in patients with metastatic colon cancer in CONFIRM-1 and -2 clinical trials.
Neoplasms
TS mRNA levels can predict pemetrexed and raltitrexed sensitivity in colorectal cancer.
Neoplasms
TS, DHFR and GARFT expression in non-squamous cell carcinoma of NSCLC and malignant pleural mesothelioma patients treated with pemetrexed.
Neoplasms
Tumor cell responses to inhibition of thymidylate synthase.
Neoplasms
Tumor dihydropyrimidine dehydrogenase activity in advanced cervical carcinoma.
Neoplasms
Tumor growth inhibition in vivo and G2/M cell cycle arrest induced by antisense oligodeoxynucleotide targeting thymidylate synthase.
Neoplasms
Tumor thymidylate synthase 1494del6 genotype as a prognostic factor in colorectal cancer patients receiving fluorouracil-based adjuvant treatment.
Neoplasms
Tumor-related gene expression levels in thymic carcinoma and Type B3 thymoma.
Neoplasms
Tumor-selective metabolism of 5-fluoro-2'-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma.
Neoplasms
Two proliferation-related proteins, TYMS and PGK1, could be new cytotoxic T lymphocyte-directed tumor-associated antigens of HLA-A2+ colon cancer.
Neoplasms
Tyrosine nitration affects thymidylate synthase properties.
Neoplasms
UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan.
Neoplasms
Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality.
Neoplasms
Unresolved issues in the biochemical pharmacology of antifolates.
Neoplasms
Up-regulation in dihydropyrimidine dehydrogenase activity by raltitrexed causes antagonism in combination with 5-fluorouracil.
Neoplasms
Up-regulation of resistance-related proteins in human lung tumors with poor vascularization.
Neoplasms
Upregulation of enzymes metabolizing 5-fluorouracil in colorectal cancer.
Neoplasms
Variation in the expression levels of predictive chemotherapy biomarkers in histological subtypes of lung adenocarcinoma: an immunohistochemical study of tissue samples.
Neoplasms
Vascular endothelial growth factor expression, S-phase fraction and thymidylate synthase quantitation in node-positive colon cancer: relationships with tumor recurrence and resistance to adjuvant chemotherapy.
Neoplasms
Where should the specimen be excised for the chemosensitivity of colorectal cancer to 5-fluorouracil?
Neoplasms
ZD-9331 AstraZeneca.
Neoplasms
ZD9331 in combination with topotecan: phase I and II experience.
Neoplasms
ZD9331: discovery to clinical development.
Neoplasms
[A case of long-term survival after undergoing s-1 based multidisciplinary therapy for liver metastasis of gastric cancer].
Neoplasms
[A case of uterine cervical cancer in which UFT was an effective preoperative treatment]
Neoplasms
[A complete response after neoadjuvant chemotherapy for advanced gastric cancer with esophageal invasion]
Neoplasms
[Antimetastatic and antitumor effects of fluoropyrimidines alone and combined with taxanes in a murine model of breast cancer metastatic to the lung]
Neoplasms
[Antitumor activity and function of S-1, a new oral tegafur-based formulation]
Neoplasms
[Changes in folate levels after cisplatin treatment of gastric cancer]
Neoplasms
[Comparison between continuous intravenous and oral administration of 5-FU with LV]
Neoplasms
[Comparison between leucovorin and cisplatin as a modulator of 5-fluorouracil]
Neoplasms
[Dihydropyrimidine dehydrogenase and thymidylate synthase in colon carcinoma]
Neoplasms
[DNA biosynthesis in the liver of animals with extrahepatic tumors: the role of thymidylate synthetase]
Neoplasms
[Double promoters induct suicide gene target killing of 5-FU drug-fast cancer cells]
Neoplasms
[Dual biochemical modulation therapy using 5-FU, leucovorin and cisplatin on human rectal carcinoma xenografts in nude mouse]
Neoplasms
[Effect and mechanism of orally administered leucovorin/5-fluorouracil on colon cancer]
Neoplasms
[Evaluation of chemosensitivity testing by CD-DST, and TS and DPD activity in cases of colorectal liver]
Neoplasms
[Evaluation of combination chemotherapy with 5-FU and CDDP for human gastric carcinoma transplanted into nude mice]
Neoplasms
[Expression of metabolic enzymes of fluoropyrimidines in primary colorectal cancer and its clinical significance]
Neoplasms
[Influence on 5-fluorouracil metabolism by combination of interferon-alpha and 5-fluorouracil against human hepatocellular carcinoma xenografts]
Neoplasms
[Inhibition of thymidylate synthetase and antiproliferative effect by 1-hexylcarbamoyl-5-fluorouracil]
Neoplasms
[Level of inhibition of thymidylate synthase activity and 5-fluorouracil in tumor tissues after administration of UFT or tegafur]
Neoplasms
[Metastatic colorectal cancer: new therapeutics]
Neoplasms
[Molecular cloning and molecular biological studies of human thymidylate synthase gene]
Neoplasms
[Molecular markers as basis for chemotherapy?]
Neoplasms
[Neo-adjuvant chemotherapy with tegafur suppository for rectal cancer--evaluation of the antitumor effects, tissue levels of 5-FU and inhibition of thymidylate synthase. Tochigi Colorectal Cancer Study Group]
Neoplasms
[Pharmacological and biochemical investigation of intracavital fluorinated pyrimidine chemotherapy]
Neoplasms
[Phase I study of raltitrexed (ZD-1694)]
Neoplasms
[Prediction of the efficacy of modified FOLFOX6 therapy according to the mRNA levels of thymidylate synthase (TS), excision repair cross-complementing-1 and -2( ERCC-1 and ERCC-2) and methylenetetrahydrofolate dehydrogenase( MTHFD) in the primary lesion of colorectal cancer].
Neoplasms
[Relationship between antitumor activity and the inhibition of thymidylate synthase after oral administration of UFT in nude mice bearing human tumor]
Neoplasms
[Relationship between the expression of P-glycoprotein, glutathione S-transferase-pi and thymidylate synthase proteins and adenosine triphosphate tumor chemosensitivity assay in cervical cancer]
Neoplasms
[Studies of the antitumor activity and enzymology of 2'-deoxy-5-fluorouridine (FdUrd) derivatives]
Neoplasms
[Studies on the mechanism of antitumor activity of 5-FU and its derivatives--relationship between the inhibition of tumor growth and the inhibition of thymidylate synthetase in vivo]
Neoplasms
[The association of expression and gene polymorphism of the thymidylate synthase gene with 5-fluoro-5'-deoxyuridine sensitivity in gastric cancer cell lines]
Neoplasms
[The correlation between thymidylate synthase expression and cytotoxicity of 5-fluorouracil in human cancer cell lines: study using polyclonal antibody against recombinant human thymidylate synthase]
Neoplasms
[The determination of thymidylate synthetase inhibition for testing fluoropyrimidines--pharmacokinetics and metabolism of carmofur (HCFU) in patients with gynecologic malignancies--Tokai HCFU Study Group for Gynecologic Malignancies]
Neoplasms
[The expression of thymidylate synthase (TS) and excision repair complementing-1 (ERCC-1) protein in patients with unresectable colorectal cancer treated with mFOLFOX6 therapy].
Neoplasms
[The mechanism of potentiation of the antitumor effect of 5-fluorouracil by methionine-free intravenous amino acid solution (AO-90) in rats]
Neoplasms
[The Relationship between the efficacy of mFOLFOX6 treatment and the expression of TS, DPD, TP, and ERCC-1 in unresectable colorectal cancer].
Neoplasms
[The role of vitamin B6 in tumor growth]
Neoplasms
[The significance of measuring inhibition of thymidylate synthase activity as a parameter for antitumor activity of 5-fluorouracil derivatives]
Neoplasms
[Theoretical basis for low-dose CDDP/5-FU therapy]
Neoplasms
[Thymidylate synthase and dihydropyrimidine dehydrogenase activity in a metastatic liver tumor from colorectal cancer]
Neoplasms
[Thymidylate synthase and dihydropyrimidine dehydrogenase expression and histological effects of preoperative UFT in gastric cancer patients]
Neoplasms
[Thymidylate synthase and dihydropyrimidine dehydrogenase gene expressions in colorectal cancer using the Danenberg tumor profile method]
Neoplasms
[Thymidylate synthase expression in patients with hypopharyngeal carcinoma]
Neoplasms
[Thymidylate synthase inhibition and concentration of 5-fluorouracil after administration of UFT in human uroepithelial carcinomas]
Neoplasms
[Thymidylate synthase inhibition in malignant tumors after oral administration of UFT]
Neoplasms
[Thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in soft-tissue sarcoma versus capecitabine potential]
Neoplasms
[UFT/CDDP preoperative chemotherapy for progressive gastric cancer--histological antitumor effects and thymidylate synthase inhibition rate]
Neoplastic Cells, Circulating
Molecular and Dynamic Evaluation of Proteins Related to Resistance to Neoadjuvant Treatment with Chemoradiotherapy in Circulating Tumor Cells of Patients with Locally Advanced Rectal Cancer.
Neoplastic Cells, Circulating
Thymidylate synthase expression in circulating tumor cells: A new tool to predict 5-fluorouracil resistance in metastatic colorectal cancer patients.
Neural Tube Defects
Thymidylate synthase repeat polymorphisms and risk of neural tube defects in a population from the northern United Kingdom.
Neuroblastoma
5,10-Methenyltetrahydrofolate synthetase activity is increased in tumors and modifies the efficacy of antipurine LY309887.
Neuroblastoma
A comparison of thymidylate synthetase activities from 5-fluorodeoxyuridine sensitive and resistant variants of mouse neuroblastoma.
Neuroblastoma
Altered thymidine kinase or thymidylate synthetase activities in 5-fluoro deoxyuridine resistant variants of mouse neuroblastoma.
Neuroblastoma
Experimental chemotherapy of neuroblastoma. II. Increased thymidylate synthetase activity in a 5-fluorodeoxyuridine-resistant variant of mouse neuroblastoma.
Neuroblastoma
Quinazoline antifolates as inhibitors of growth, dihydrofolate reductase, and thymidylate synthetase of mouse neuroblastoma cells in culture.
Neuroblastoma
Regulation of the synthesis of choline-O-acetyltransferase and thymidylate synthetase in mouse neuroblastoma in cell culture.
Neuroblastoma
Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines.
Neuroblastoma
Thymidylate synthase inhibitor raltitrexed can induce high levels of DNA damage in MYCN-amplified neuroblastoma cells.
Neuroectodermal Tumors
Thymidylate synthase 1 (ts1) in-situ protein expression predicts the survival of ewing/pnet.
Neuroendocrine Tumors
Thymidylate synthase expression in gastroenteropancreatic and pulmonary neuroendocrine tumors.
Neutropenia
Folate pathway genetic polymorphisms modulate methotrexate-induced toxicity in childhood acute lymphoblastic leukemia.
Opportunistic Infections
Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections.
Oropharyngeal Neoplasms
Evaluation of pemetrexed and etoposide as therapeutic regimens for human papillomavirus-positive oral and oropharyngeal cancer.
Osteonecrosis
A Pharmacogenetic Study of VDR fok1 and TYMS Polymorphisms and Their Association With Glucocorticoid-Induced Osteonecrosis in Egyptian Children With Acute Lymphoblastic Leukemia.
Osteonecrosis
Pharmacogenetic risk factors for osteonecrosis of the hip among children with leukemia.
Osteonecrosis
[Osteonecroses of the bilateral tali during maintenance therapy in a child with acute lymphoblastic leukemia]
Osteosarcoma
mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma.
Osteosarcoma
Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.
Ovarian Neoplasms
A phase II study to determine the efficacy and tolerability of intravenous ZD9331 in heavily pretreated patients with ovarian cancer.
Ovarian Neoplasms
An RNAi therapeutic, DFP-10825, for intraperitoneal and intrapleural malignant cancers.
Ovarian Neoplasms
Anticancer activity of the intraperitoneal-delivered DFP-10825, the cationic liposome-conjugated RNAi molecule targeting thymidylate synthase, on peritoneal disseminated ovarian cancer xenograft model.
Ovarian Neoplasms
Antitumor activity of oxaliplatin in combination with 5-fluorouracil and the thymidylate synthase inhibitor AG337 in human colon, breast and ovarian cancers.
Ovarian Neoplasms
Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells.
Ovarian Neoplasms
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth.
Ovarian Neoplasms
Folate and folate receptor alpha antagonists mechanism of action in ovarian cancer.
Ovarian Neoplasms
Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth.
Ovarian Neoplasms
Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.
Ovarian Neoplasms
Internalization and stability of a thymidylate synthase Peptide inhibitor in ovarian cancer cells.
Ovarian Neoplasms
Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth.
Ovarian Neoplasms
Phase II clinical trial of capecitabine in ovarian carcinoma recurrent 6-12 months after completion of primary chemotherapy, with exploratory TS, DPD, and TP correlates: a Gynecologic Oncology Group study.
Ovarian Neoplasms
Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations.
Ovarian Neoplasms
Synergy between the non-classical thymidylate synthase inhibitor AG337 (Thymitaq) and cisplatin in human colon and ovarian cancer cells.
Ovarian Neoplasms
Thymidylate synthase activity as a prognostic factor in ovarian cancer.
Paget Disease, Extramammary
Thymidylate synthase overexpression in extramammary Paget's disease.
Pancreatic Neoplasms
A Pilot Trial of Molecularly Tailored Therapy for Patients with Metastatic Pancreatic Ductal Adenocarcinoma.
Pancreatic Neoplasms
Accomplishments in 2007 in biologic markers for gastrointestinal cancers.
Pancreatic Neoplasms
Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk.
Pancreatic Neoplasms
Association of thymidylate synthase and hypoxia inducible factor-1alpha DNA polymorphisms with pancreatic cancer.
Pancreatic Neoplasms
Clinical significance of dihydropyrimidine dehydrogenase and thymidylate synthase expression in patients with pancreatic cancer.
Pancreatic Neoplasms
Combined Analyses of hENT1, TS, and DPD Predict Outcomes of Borderline-resectable Pancreatic Cancer.
Pancreatic Neoplasms
Contribution of thymidylate synthase to gemcitabine therapy for advanced pancreatic cancer.
Pancreatic Neoplasms
Genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase and risk of pancreatic cancer.
Pancreatic Neoplasms
In vivo evaluation of 5-[(18)F]fluoro-2'-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model.
Pancreatic Neoplasms
Modulation of 5-fluorouracil resistance in human colon tumor cell lines by azidothymidine.
Pancreatic Neoplasms
New approaches to the treatment of gastro-intestinal cancer.
Pancreatic Neoplasms
Prognostic Value of c-MET Expression in Patients With Pancreatic Cancer Receiving Adjuvant and Neoadjuvant Chemoradiation Therapy.
Pancreatic Neoplasms
Third International Conference on Biology, Prevention and Treatment of Gastrointestinal Malignancies. Cologne, 23-26 September 1998.
Pancreatic Neoplasms
Thymidylate synthase (TYMS) enhancer region genotype-directed phase II trial of oral capecitabine for 2nd line treatment of advanced pancreatic cancer.
Pancreatic Neoplasms
Thymidylate synthase expression in resectable and unresectable pancreatic cancer: role as predictive or prognostic marker?
Pancreatic Neoplasms
Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer.
Pancreatic Neoplasms
[Relationship between antitumor activity and the inhibition of thymidylate synthase after oral administration of UFT in nude mice bearing human tumor]
Pancreatitis
Association of Thymidylate Synthase Polymorphisms with Acute Pancreatitis and/or Peripheral Neuropathy in HIV-Infected Patients on Stavudine-Based Therapy.
Pancytopenia
Pancytopenia and Severe Gastrointestinal Toxicities Associated with 5-Fluorouracil in a Patient with Thymidylate Synthase (TYMS) Polymorphism.
Papilloma
Suppression by kampo medicine, sho-saiko-to, on papillomas induced by 7,12-dimethylbenz(a)anthracene in mice.
Penile Neoplasms
Epidermal Growth Factor Receptor, Excision-Repair Cross-Complementation Group 1 Protein, and Thymidylate Synthase Expression in Penile Cancer.
Penile Neoplasms
[Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in penile cancer].
Peripheral Nervous System Diseases
Association of Thymidylate Synthase Polymorphisms with Acute Pancreatitis and/or Peripheral Neuropathy in HIV-Infected Patients on Stavudine-Based Therapy.
Peroneal Neuropathies
First Case of Foot Drop Associated with Capecitabine in a Patient with Thymidylate Synthase Polymorphism.
Placenta Diseases
Human trophoblast stem cells: Real or not real?
Pneumonia
Biodiversity of Pneumocystis carinii hominis: typing with different DNA regions.
Pneumonia
The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.
Pneumonia, Pneumocystis
Biodiversity of Pneumocystis carinii hominis: typing with different DNA regions.
Pneumonia, Pneumocystis
Inability of Pneumocystis organisms to incorporate bromodeoxyuridine suggests the absence of a salvage pathway for thymidine.
Pre-Eclampsia
ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A thymidylate synthase polymorphism is associated with increased risk for bone toxicity among children treated for acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
beta-Carboline-benzoquinolizidine alkaloid deoxytubulosine inhibits thymidylate synthase activity in leukemic leukocytes from patients with chronic myeloblastic leukemia and acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Combined therapeutic efficacy of the thymidylate synthase inhibitor ZD1694 (Tomudex) and the immunotoxin B43(anti-CD19)-PAP in a SCID mouse model of human B-lineage acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Comparative pharmacogenetic analysis of risk polymorphisms in Caucasian and Vietnamese children with acute lymphoblastic leukemia: prediction of therapeutic outcome?
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Differential methotrexate resistance in childhood T- versus common/preB-acute lymphoblastic leukemia can be measured by an in situ thymidylate synthase inhibition assay, but not by the MTT assay.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effects of thymidylate synthase polymorphisms on toxicities associated with high-dose methotrexate in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Ex vivo resistance in childhood acute lymphoblastic leukemia: Correlations between BCRP, MRP1, MRP4 and MRP5 ABC transporter expression and intracellular methotrexate polyglutamate accumulation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Impact of thymidylate synthase promoter and DNA repair gene polymorphisms on susceptibility to childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Mechanisms of resistance to methotrexate in childhood acute lymphoblastic leukemia: circumvention of thymidylate synthase inhibition.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Messenger RNA expression of resistance factors and their correlation to the proliferative activity in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polymorphism of the thymidylate synthase gene and risk of relapse in childhood ALL.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The influence of cyclin D1 (CCND1) 870A>G polymorphism and CCND1-thymidylate synthase (TS) gene-gene interaction on the outcome of childhood acute lymphoblastic leukaemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The role of genetic polymorphisms in the thymidylate synthase (TYMS) gene in methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thymidylate synthase activity in leukocytes from patients with chronic myelocytic leukemia and acute lymphocytic leukemia and its inhibition by phenanthroindolizidine alkaloids pergularinine and tylophorinidine.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thymidylate synthase and methionine synthase polymorphisms are not associated with susceptibility to childhood acute lymphoblastic leukemia in Kurdish population from Western Iran.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thymidylate synthase enhancer region polymorphism not related to susceptibility to acute lymphoblastic leukemia in the Kashmir population.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thymidylate synthase gene polymorphism and its association with relapse in childhood B-cell precursor acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
TSER polymorphism is not associated with risk of pediatric acute lymphoblastic leukemia: A meta-analysis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Influence of thymidylate synthase gene polymorphisms on high-dose methotrexate-related toxicities in childhood acute lymphoblastic leukemia].
Pregnancy Complications
ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta.
Pregnancy Complications
Human trophoblast stem cells: Real or not real?
Presbycusis
Polymorphisms in folate metabolism genes are associated with susceptibility to presbycusis.
Primary Ovarian Insufficiency
Association of methylenetetrahydrofolate reductase (MTHFR 677C>T) and thymidylate synthase (TSER and TS 1494del6) polymorphisms with premature ovarian failure in Korean women.
Prostatic Neoplasms
Biomodulation of 5-Fu cytotoxicity by folinic acid and its stereoisomers: in vitro experiments with different cell lines of prostatic cancer.
Prostatic Neoplasms
Evaluation of Thymidylate Synthase Expression in Prostate Cancer.
Prostatic Neoplasms
Expression of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyl transferase in prostate cancer.
Prostatic Neoplasms
High-grade and hormone-treated prostate cancer express high levels of thymidylate synthase.
Prostatic Neoplasms
Hydroxyflutamide enhances cellular sensitivity to 5-fluorouracil by suppressing thymidylate synthase expression in bicalutamide-resistant human prostate cancer cells.
Prostatic Neoplasms
Methionine restriction selectively targets thymidylate synthase in prostate cancer cells.
Prostatic Neoplasms
Overexpression of thymidylate synthase (TYMS) is associated with aggressive tumor features and early PSA recurrence in prostate cancer.
Prostatic Neoplasms
Prognostic significance of thymidylate synthase expression in patients with prostate cancer undergoing radical prostatectomy.
Prostatic Neoplasms
The novel heterodinucleoside dimer 5-FdU-NOAC is a potent cytotoxic drug and a p53-independent inducer of apoptosis in the androgen-independent human prostate cancer cell lines PC-3 and DU-145.
Rectal Neoplasms
A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation.
Rectal Neoplasms
Association of thymidylate synthase polymorphisms with the tumor response to preoperative chemoradiotherapy in rectal cancer: a systematic review and meta-analysis.
Rectal Neoplasms
Biological predictive factors in rectal cancer treated with preoperative radiotherapy or radiochemotherapy.
Rectal Neoplasms
Correlation of spectral imaging and visual grading for the quantification of thymidylate synthase protein expression in rectal cancer.
Rectal Neoplasms
EGFR ligands and DNA repair genes: genomic predictors of complete response after capecitabine-based chemoradiotherapy in locally advanced rectal cancer.
Rectal Neoplasms
Elevated Microsatellite Alterations at Selected Tetranucleotide Repeats (EMAST) and Microsatellite Instability in Patients with Colorectal Cancer and Its Clinical Features.
Rectal Neoplasms
Enhancing chemoradiation of colorectal cancer through targeted delivery of raltitrexed by hyaluronic acid coated nanoparticles.
Rectal Neoplasms
Germline polymorphisms may act as predictors of response to preoperative chemoradiation in locally advanced T3 rectal tumors.
Rectal Neoplasms
Glutathione S-transferase P1 Ile105Val polymorphism is associated with haematological toxicity in elderly rectal cancer patients receiving preoperative chemoradiotherapy.
Rectal Neoplasms
High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction.
Rectal Neoplasms
High survivin expression as a predictor of poor response to preoperative chemoradiotherapy in locally advanced rectal cancer.
Rectal Neoplasms
Immunohistochemical analysis of thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer (cUICC II/III): correlation with histopathologic tumor regression after 5-fluorouracil-based long-term neoadjuvant chemoradiotherapy.
Rectal Neoplasms
Immunohistochemical Markers as Predictors of Histopathologic Response and Prognosis in Rectal Cancer Treated with Preoperative Adjuvant Therapy: State of the Art.
Rectal Neoplasms
Importance of thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase expression at the invasive front of T3 rectal cancer as prognostic factors.
Rectal Neoplasms
p53, deleted in colorectal cancer gene, and thymidylate synthase as predictors of histopathologic response and survival in low, locally advanced rectal cancer treated with preoperative adjuvant therapy.
Rectal Neoplasms
Pharmacogenetic analysis in neoadjuvant chemoradiation for rectal cancer: high incidence of somatic mutations and their relation with response.
Rectal Neoplasms
Pharmacogenetic Study in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy: Polymorphisms in Thymidylate Synthase, Epidermal Growth Factor Receptor, GSTP1, and DNA Repair Genes.
Rectal Neoplasms
Phase I study of concomitant chemoradiation with raltitrexed in locally advanced head and neck cancer.
Rectal Neoplasms
Polymorphisms in the thymidylate synthase gene and risk of colorectal cancer.
Rectal Neoplasms
Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer.
Rectal Neoplasms
Predictive value of Ki67 and p53 in locally advanced rectal cancer: correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy.
Rectal Neoplasms
Preoperative Chemoradiation for Rectal Cancer Using Capecitabine and Celecoxib Correlated with Posttreatment Assessment of Thymidylate Synthase and Thymidine Phosphorylase Expression.
Rectal Neoplasms
Pretreatment Expression of 13 Molecular Markers as a Predictor of Tumor Responses After Neoadjuvant Chemoradiation in Rectal Cancer.
Rectal Neoplasms
Prognostic and predictive value of baseline and posttreatment molecular marker expression in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy.
Rectal Neoplasms
Prognostic Significance Of Thymidylate Synthase Polymorphisms In Rectal Cancer Patients Treated With Neoadjuvant Chemoradiotherapy.
Rectal Neoplasms
Prognostic value of histologic tumor regression, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer UICC Stage II/III after neoadjuvant chemoradiotherapy.
Rectal Neoplasms
The impact of surgically induced ischaemia on protein levels in patients undergoing rectal cancer surgery.
Rectal Neoplasms
The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer.
Rectal Neoplasms
Thymidylate Synthase as a Prognostic Biomarker for Locally Advanced Rectal Cancer after multimodal Treatment.
Rectal Neoplasms
Thymidylate synthase expression in rectal cancer and proliferation, assessed by cyclin A and Ki-67 expression.
Rectal Neoplasms
Thymidylate synthase expression: an independent prognostic factor for local recurrence, distant metastasis, disease-free and overall survival in rectal cancer.
Rectal Neoplasms
Thymidylate Synthase Gene Polymorphism Affects the Response to Preoperative 5-Fluorouracil Chemoradiation Therapy in Patients With Rectal Cancer.
Rectal Neoplasms
Thymidylate synthase genotypes and tumour regression in stage II/III rectal cancer patients after neoadjuvant fluorouracil-based chemoradiation.
Rectal Neoplasms
Thymidylate synthase germline polymorphisms in rectal cancer patients treated with neoadjuvant chemoradiotherapy based on 5-fluorouracil.
Rectal Neoplasms
Thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase expression, and histological tumour regression after 5-FU-based neo-adjuvant chemoradiotherapy in rectal cancer.
Rectal Neoplasms
X-Ray Cross-Complementing Group 1 and Thymidylate Synthase Polymorphisms Might Predict Response to Chemoradiotherapy in Rectal Cancer Patients.
Rectal Neoplasms
[Neo-adjuvant chemotherapy with tegafur suppository for rectal cancer--evaluation of the antitumor effects, tissue levels of 5-FU and inhibition of thymidylate synthase. Tochigi Colorectal Cancer Study Group]
Relapsing Fever
Function and evolution of plasmid-borne genes for pyrimidine biosynthesis in Borrelia spp.
Retinoblastoma
Coordinated trans activation of DNA synthesis- and precursor-producing enzymes by polyomavirus large T antigen through interaction with the retinoblastoma protein.
Retinoblastoma
Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases.
Retinoblastoma
MTR polymorphic variant A2756G and retinoblastoma risk in Brazilian children.
Retinoblastoma
Multiple molecular alterations in mouse lung tumors.
Sarcoma
Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
Sarcoma
Bevacizumab, Pemetrexed, and Cisplatin, or Bevacizumab and Erlotinib for Patients With Advanced Non-Small-Cell Lung Cancer Stratified by Epidermal Growth Factor Receptor Mutation: Phase II Trial SAKK19/09.
Sarcoma
Horse v-fes feline sarcoma viral oncogene homologue; pyruvate kinase, muscle type 2; plasminogen; beta spectrin, non-erythrocytic 1; thymidylate synthetase; and microsatellite LEX078 map to 1q14-q15, 1q21, 31q12-q14, 15q22, 8q12-q14, and 14q27, respectively.
Sarcoma
Identification of predictive biomarkers for the histone deacetylase inhibitor belinostat in a panel of human cancer cell lines.
Sarcoma
Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells.
Sarcoma
Prediction of antifolate efficacy in a rat sarcoma model.
Sarcoma
Use of molecular biomarkers to inform adjuvant therapy for colon cancer.
Sarcoma
[Thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in soft-tissue sarcoma versus capecitabine potential]
Sarcoma 180
Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography.
Sarcoma 180
[The significance of measuring inhibition of thymidylate synthase activity as a parameter for antitumor activity of 5-fluorouracil derivatives]
Sarcoma, Kaposi
Human herpesvirus 8 gene encodes a functional thymidylate synthase.
Sarcoma, Yoshida
Schedule dependent inhibition of thymidylate synthase and tumor growth by 5-fluorouracil in Yoshida sarcoma bearing rats.
Sarcoma, Yoshida
[Mechanism for synergistic antitumor effect in the combination of 5-fluorouracil with cisplatin in vivo tumor models: from the view of biochemical modulation of 5-fluorouracil]
Sigmoid Neoplasms
Dependence of the thymidylate synthase inhibition rate on the interval after the last administration of tegafur in sigmoid colon cancer patients.
Skin Neoplasms
Intratumor dihydropyrimidine dehydrogenase mRNA expression levels are decreased in extramammary Paget's disease.
Small Cell Lung Carcinoma
Biochemical and pharmacologic rationale for high-dose methotrexate.
Smooth Muscle Tumor
PTEN, tau-AP-3, thymidylate synthase immunohistochemistry scoring expression in patients with uterine leiomyomas, uterine smooth muscle tumors of uncertain malignancy potential and uterine leiomyosarcomas.
Spinal Dysraphism
Associations between polymorphisms within the thymidylate synthase gene and spina bifida.
Squamous Cell Carcinoma of Head and Neck
Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
Squamous Cell Carcinoma of Head and Neck
Association between dietary folate intake and clinical outcome in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Carboplatin in combination with raltitrexed in recurrent and metastatic head and neck squamous cell carcinoma: A multicentre phase II study of the Gruppo Oncologico Dell'Italia Meridionale (G.O.I.M.).
Squamous Cell Carcinoma of Head and Neck
Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.
Squamous Cell Carcinoma of Head and Neck
Correlations between thymidylate synthase expression and chemosensitivity to 5-fluorouracil, cell proliferation and clinical outcome in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Effects of smoking and alcohol consumption on 5-fluorouracil-related metabolic enzymes in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Evaluation of TS-1 based treatment and expression of thymidylate synthase and dihydropyrimidine dehydrogenase on oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Expression levels of thymidylate synthase, thymidylate phosphorylase and dihydropyrimidine dehydrogenase in head and neck squamous cell carcinoma: preliminary study.
Squamous Cell Carcinoma of Head and Neck
Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in oral squamous cell carcinoma: possible markers as predictors of clinical outcome.
Squamous Cell Carcinoma of Head and Neck
Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in primary oral squamous cell carcinoma and corresponding metastases in cervical lymph nodes: association with the metastasis suppressor CD82.
Squamous Cell Carcinoma of Head and Neck
One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study.
Squamous Cell Carcinoma of Head and Neck
Predictive value of immunohistochemical thymidylate synthase expression for histological response to Tegafur/Uracil (UFT) in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Relative level of thymidylate synthase mRNA expression in primary tumors and normal tissues predicts survival of patients with oral tongue squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Study of Thymidylate Synthase (TS) and Dihydropyrimidine Dehydrogenase (DPD) Expressions on 5-Fluorouracil in Oral Squamous Cell Carcinoma
Squamous Cell Carcinoma of Head and Neck
Synergistic antitumour effect of raltitrexed and 5-fluorouracil plus folinic acid combination in human cancer cells.
Squamous Cell Carcinoma of Head and Neck
Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.
Squamous Cell Carcinoma of Head and Neck
The effect of neoadjuvant therapy on the 5-fluorouracil metabolic and relative enzymes of oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Thymidylate synthase activity, folates, and glutathione system in head and neck carcinoma and adjacent tissues.
Squamous Cell Carcinoma of Head and Neck
Thymidylate synthase and dihydropyrimidine dehydrogenase expression in oral squamous cell carcinoma: an immunohistochemical and clinicopathologic study.
Squamous Cell Carcinoma of Head and Neck
Thymidylate synthase as a target for growth inhibition in methotrexate-sensitive and -resistant human head and neck cancer and leukemia cell lines.
Squamous Cell Carcinoma of Head and Neck
Thymidylate synthase expression in oral squamous cell carcinoma predicts response to S-1.
Squamous Cell Carcinoma of Head and Neck
Thymidylate synthase, thymidine phosphorylase and orotate phosphoribosyl transferase levels as predictive factors of chemotherapy in oral squamous cell carcinoma.
Starvation
Assessment of pegylated arginine deiminase and modified FOLFOX6 in patients with advanced hepatocellular carcinoma: Results of an international, single-arm, phase 2 study.
Stomach Neoplasms
2R of Thymidylate Synthase 5'-untranslated Enhanced Region Contributes to Gastric Cancer Risk: a Meta-analysis.
Stomach Neoplasms
3R Variant of Thymidylate Synthase 5'-untranslated Enhanced Region Contributes to Colorectal Cancer Risk: A Meta-analysis.
Stomach Neoplasms
A novel intraperitoneal therapy for gastric cancer with DFP-10825, a unique RNAi therapeutic targeting thymidylate synthase, in a peritoneally disseminated xenograft model.
Stomach Neoplasms
A predictive factor for the response to S-1 plus cisplatin in gastric cancer.
Stomach Neoplasms
Activities of thymidylate synthetase and thymidine kinase in gastric cancer.
Stomach Neoplasms
An integrated analysis of the association between Ts gene polymorphisms and clinical outcome in gastric and colorectal cancer patients treated with 5-FU-based regimens.
Stomach Neoplasms
Antitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins.
Stomach Neoplasms
Apoptosis and thymidylate synthase inductions by 5-fluorouracil in gastric cancer cells with or without p53 mutation.
Stomach Neoplasms
Association between polymorphisms of thymidylate synthase gene 5'- and 3'-UTR and gastric cancer risk: meta-analysis.
Stomach Neoplasms
Association of thymidylate synthase expression and clinical outcomes of gastric cancer patients treated with fluoropyrimidine-based chemotherapy: a meta-analysis.
Stomach Neoplasms
Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer.
Stomach Neoplasms
Association of thymidylate synthase polymorphisms with gastric cancer susceptibility.
Stomach Neoplasms
Bax Predicts Outcome in Gastric Cancer Patients Treated with 5-fluorouracil, Leucovorin, and Oxaliplatin Palliative Chemotherapy.
Stomach Neoplasms
Biological markers as a predictor for response and prognosis of unresectable gastric cancer patients treated with irinotecan and cisplatin.
Stomach Neoplasms
Changes in intratumoral thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression in colorectal and gastric cancer during continuous tegafur infusion.
Stomach Neoplasms
Changes in thymidylate synthase and its inhibition rate and changes in dihydropyrimidine dehydrogenase after the administration of 5-fluorouracil with cisplatin to nude mice with gastric cancer xenograft SC-1-NU.
Stomach Neoplasms
Changes of gene expression of thymidine phosphorylase, thymidylate synthase, dihydropyrimidine dehydrogenase after the administration of 5'-deoxy-5-fluorouridine, paclitaxel and its combination in human gastric cancer xenografts.
Stomach Neoplasms
Clinical implications of immunoreactivity of thymidylate synthase and dihydropyrimidine dehydrogenase in gastric cancer treated with oral fluoropyrimidine (S-1). Study Group of S-1 for Gastric Cancer.
Stomach Neoplasms
Clinicopathologic significance of ERCC1, thymidylate synthase and glutathione S-transferase P1 expression for advanced gastric cancer patients receiving adjuvant 5-FU and cisplatin chemotherapy.
Stomach Neoplasms
Comprehensive analysis of excision repair complementation group 1, glutathione S-transferase, thymidylate synthase and uridine diphosphate glucuronosyl transferase 1A1 polymorphisms predictive for treatment outcome in patients with advanced gastric cancer treated with FOLFOX or FOLFIRI.
Stomach Neoplasms
Comprehensive biomarker analyses identifies HER2, EGFR, MET RNA expression and thymidylate synthase 5'UTR SNP as predictors of benefit from S-1 adjuvant chemotherapy in Japanese patients with stage II/III gastric cancer.
Stomach Neoplasms
Correlation between expression of thymidylate synthase and clinical outcome of advanced gastric cancer treated with capecitabine alone chemotherapy.
Stomach Neoplasms
Correlation between thymidylate synthase and dihydropyrimidine dehydrogenase mRNA level and in vitro chemosensitivity to 5-fluorouracil, in relation to differentiation in gastric cancer.
Stomach Neoplasms
Dihydropyrimidine dehydrogenase and messenger RNA levels in gastric cancer: possible predictor for sensitivity to 5-fluorouracil.
Stomach Neoplasms
Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer.
Stomach Neoplasms
Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase.
Stomach Neoplasms
ERCC1 mRNA levels and survival of advanced gastric cancer patients treated with a modified FOLFOX regimen.
Stomach Neoplasms
ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy.
Stomach Neoplasms
Erratum to: Impact of the expression of thymidylate synthase and dihydropyrimidine dehydrogenase genes on survival in stage II/III gastric cancer.
Stomach Neoplasms
Evaluation of prognostic factors for the response to S-1 in patients with stage II or III advanced gastric cancer who underwent gastrectomy.
Stomach Neoplasms
Expression of a molecular marker panel as a prognostic tool in gastric cancer patients treated postoperatively with docetaxel and irinotecan. A study of the Hellenic Cooperative Oncology Group.
Stomach Neoplasms
Expression of multidrug resistance-associated protein1,P-glycoprotein, and thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection.
Stomach Neoplasms
Expression of thymidylate synthase and thymidine phosphorylase in recurrence and survival rates of advanced gastric cancer.
Stomach Neoplasms
Expression of thymidylate synthase determines the response of gastric cancer patients undergoing gastrectomy to 5-fluorouracil-based adjuvant chemotherapy.
Stomach Neoplasms
Expression of thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection.
Stomach Neoplasms
Expression of thymidylate synthase in relation to survival and chemosensitivity in gastric cancer patients.
Stomach Neoplasms
Expression of thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase, E2F-1, Bak, Bcl-X, and Bcl-2, and clinical outcomes for gastric cancer patients treated with bolus 5-fluorouracil.
Stomach Neoplasms
Expressions of Thymidylate Synthase,Thymidine Phosphorylase, Class III ?-tubulin, and Excision Repair Cross-complementing Group 1predict Response in Advanced Gastric Cancer Patients Receiving Capecitabine Plus Paclitaxel or Cisplatin.
Stomach Neoplasms
Folate intake along with genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase in patients with advanced gastric cancer.
Stomach Neoplasms
Gene expression of 5-fluorouracil metabolic enzymes in primary gastric cancer: correlation with drug sensitivity against 5-fluorouracil.
Stomach Neoplasms
Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk and survival in gastric cancer.
Stomach Neoplasms
Histone chaperone CHAF1A impacts the outcome of fluoropyrimidines-based adjuvant therapy in gastric cancer by regulating the expression of thymidylate synthetase.
Stomach Neoplasms
Histopathological response to preoperative chemotherapy including 5-fluorouracil additionally assessed by immunocytochemical and pharmacologic parameters in patients with advanced gastric cancer.
Stomach Neoplasms
Human colorectal malignancy and oral UFT.
Stomach Neoplasms
Immunohistochemical analysis of thymidylate synthase expression in gastric carcinoma: correlation with clinicopathological parameters and survival.
Stomach Neoplasms
Immunohistochemical detection of thymidylate synthase in advanced gastric cancer: a prognostic indicator in patients undergoing gastrectomy followed by adjuvant chemotherapy with 5-fluoropyrimidines.
Stomach Neoplasms
Immunohistochemical expression of thymidylate synthase and prognosis in gastric cancer patients submitted to fluoropyrimidine-based chemotherapy.
Stomach Neoplasms
Immunostaining of thymidylate synthase and p53 for predicting chemoresistance to S-1/cisplatin in gastric cancer.
Stomach Neoplasms
Impact of the expression of thymidylate synthase and dihydropyrimidine dehydrogenase genes on survival in stage II/III gastric cancer.
Stomach Neoplasms
Impacts of fluorouracil-metabolizing enzymes on the outcomes of patients treated with S-1 alone or S-1 plus cisplatin for first-line treatment of advanced gastric cancer.
Stomach Neoplasms
Influence of TS (rs34743033) and RUNX1 (rs2014300) gene polymorphisms on survival outcomes of fluorouracil-based chemotherapy in Chinese advanced gastric cancer patients.
Stomach Neoplasms
Intratumoral heterogeneous expression of thymidylate synthase in gastric cancer.
Stomach Neoplasms
Low thymidylate synthase expression in the primary tumor predicts favorable clinical outcome in resected gastric cancer patients treated with adjuvant tegafur.
Stomach Neoplasms
Molecular Biomarker Study in a Randomised Phase III Trial of Irinotecan Plus S-1 versus S-1 for Advanced Gastric Cancer (GC0301/TOP-002).
Stomach Neoplasms
Pharmacogenetics and stomach cancer: an update.
Stomach Neoplasms
Polymorphism in the 3'-untranslated region of the thymidylate synthase gene and sensitivity of stomach cancer to fluoropyrimidine-based chemotherapy.
Stomach Neoplasms
Polymorphism of thymidylate synthase gene and chemosensitivity of 5-fluorouracil regimen in metastatic gastrointestinal cancer.
Stomach Neoplasms
Polymorphism of TS 3'-UTR predicts survival of Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel.
Stomach Neoplasms
Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking.
Stomach Neoplasms
Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS)--novel predictors for response and survival in gastric cancer patients.
Stomach Neoplasms
Polymorphisms of thymidylate synthase gene 5'- and 3'-untranslated region and risk of gastric cancer in Koreans.
Stomach Neoplasms
Polymorphisms of Thymidylate Synthase in the 5'- and 3'-Untranslated Regions and Gastric Cancer.
Stomach Neoplasms
Polymorphisms of thymidylate synthase in the 5'- and 3'-untranslated regions associated with risk of gastric cancer in South China: a case-control analysis.
Stomach Neoplasms
Prediction of clinical outcome of fluoropyrimidine-based chemotherapy for gastric cancer patients, in terms of the 5-fluorouracil metabolic pathway.
Stomach Neoplasms
Predictive value of thymidylate synthase expression in gastric cancer: a systematic review with meta-analysis.
Stomach Neoplasms
Prognostic evaluation of curatively resected locally advanced gastric cancer patients with preoperative downstaging chemotherapy assessed by histochemical and pharmacologic means.
Stomach Neoplasms
Prognostic implications of the expression of erbB2, topoisomerase II alpha and thymidylate synthase in metastatic gastric cancer after fluorouracil-based therapy.
Stomach Neoplasms
Prognostic role of thymidylate synthase polymorphisms in gastric cancer patients treated with surgery and adjuvant chemotherapy.
Stomach Neoplasms
Prognostic value of expression of ERCC1, thymidylate synthase, and glutathione S-transferase P1 for 5-fluorouracil/oxaliplatin chemotherapy in advanced gastric cancer.
Stomach Neoplasms
Prolonged and enhanced suppression of thymidylate synthase by weekly 24-h infusion of high-dose 5-fluorouracil.
Stomach Neoplasms
Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers.
Stomach Neoplasms
Quantitative double-fluorescence immunohistochemistry (qDFIHC), a novel technology to assess protein expression: A pilot study analyzing 5-FU sensitive markers thymidylate synthase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferases in gastric cancer tissue specimens.
Stomach Neoplasms
Quantitative measurement of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA level in gastric cancer by real-time RT-PCR.
Stomach Neoplasms
RAD001 shows activity against gastric cancer cells and overcomes 5-FU resistance by downregulating thymidylate synthase.
Stomach Neoplasms
Raltitrexed induces mitochondrial?mediated apoptosis in SGC7901 human gastric cancer cells.
Stomach Neoplasms
Relationship Between the DPD and TS mRNA Expression and the Response to S-1-Based Chemotherapy and Prognosis in Patients with Advanced Gastric Cancer.
Stomach Neoplasms
Relationship between the Expression of the Thymidylate Synthase and the Prognosis of Gastric Cancer Patients Treated with Combinational Chemotherapy Regimen Including Fluorouracil, Docetaxel and Cisplatin.
Stomach Neoplasms
Roles of thymidylate synthase and dihydropyrimidine dehydrogenase in tumor progression and sensitivity to 5-fluorouracil in human gastric cancer.
Stomach Neoplasms
Schedule-dependent inhibition of thymidylate synthase by 5-fluorouracil in gastric cancer.
Stomach Neoplasms
Superior antitumour activity of S-1 in tumours with a high dihydropyrimidine dehydrogenase activity.
Stomach Neoplasms
Synergistic effect of methionine-depleting total parenteral nutrition with 5-fluorouracil on human gastric cancer: a randomized, prospective clinical trial.
Stomach Neoplasms
The discrepancy in thymidylate synthase and dihydropyrimidine dehydrogenase expression depending on measurement methodologies in stage 4 gastric cancer.
Stomach Neoplasms
The polymorphisms of TS and MTHFR predict survival of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population.
Stomach Neoplasms
The thymidylate synthase tandem repeat promoter polymorphism: A predictor for tumor-related survival in neoadjuvant treated locally advanced gastric cancer.
Stomach Neoplasms
Thymidylate synthase (TS) mRNA levels in plasma and tumor as potential predictive biomarkers for raltitrexed sensitivity in gastric cancer.
Stomach Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase are related to histological effects of 5-fluorouracil and cisplatin neoadjuvant chemotherapy for primary gastric cancer patients.
Stomach Neoplasms
Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in relation to differentiation of gastric cancer.
Stomach Neoplasms
Thymidylate synthase and methylenetetrahy-drofolate reductase gene polymorphisms and gastric cancer susceptibility in a population of Northern Brazil.
Stomach Neoplasms
Thymidylate synthase and thymidine phosphorylase gene expression as predictive parameters for the efficacy of 5-fluorouracil-based adjuvant chemotherapy for gastric cancer.
Stomach Neoplasms
Thymidylate synthase gene expression in primary tumors predicts activity of s-1-based chemotherapy for advanced gastric cancer.
Stomach Neoplasms
Thymidylate synthase inhibition by an oral regimen consisting of tegafur-uracil (UFT) and low-dose leucovorin for patients with gastric cancer.
Stomach Neoplasms
Thymidylate synthase inhibitor raltitrexed can induce high levels of DNA damage in MYCN-amplified neuroblastoma cells.
Stomach Neoplasms
Thymidylate synthase polymorphism in sporadic colorectal and gastric cancer in Tunisian population: a predictive role in 5-fluorouracil based chemotherapy treatment.
Stomach Neoplasms
Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer.
Stomach Neoplasms
Thymidylate Synthase Protein Expression
Stomach Neoplasms
Thymidylate synthetase and dihydropyrimidine dehydrogenase levels in gastric cancer.
Stomach Neoplasms
UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in a sequence-dependent manner.
Stomach Neoplasms
[5-FU sensitivity and thymidylate synthase in gastric cancer]
Stomach Neoplasms
[Clinical significance of thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in Korean patients with gastric cancer]
Stomach Neoplasms
[Combination chemotherapy of S-1 and docetaxel on advanced and recurrent gastric cancer]
Stomach Neoplasms
[Effect of low dose CDDP/5-fluorouracil therapy on PCNA labeling index and TS inhibition rate of gastric cancer]
Stomach Neoplasms
[Effect of low-dose CDDP/5-FU therapy on thymidylate synthase content]
Stomach Neoplasms
[Effect of TUBB3, TS and ERCC1 mRNA expression on chemoresponse and clinical outcome of advanced gastric cancer by multiplex branched-DNA liquid chip technology].
Stomach Neoplasms
[Interactions between lifestyle, methylanetetrahydrofolate reductase gene and polymorphisms in thymidylate synthase gene with risk of stomach cancer]
Stomach Neoplasms
[The association of expression and gene polymorphism of the thymidylate synthase gene with 5-fluoro-5'-deoxyuridine sensitivity in gastric cancer cell lines]
Stomach Neoplasms
[The expression of thymidylate synthase and thymidine phosphorylase in the early-stage of gastric cancer]
Stomach Neoplasms
[The role of thymidylate synthetase in sequential dose of MTX and 5-FU in the advanced scirrhous type gastric cancer]
Stomach Neoplasms
[Thymidine kinase and thymidylate synthetase activities in human gastric cancer]
Stomach Neoplasms
[Thymidylate synthase and dihydropyrimidine dehydrogenase expression and histological effects of preoperative UFT in gastric cancer patients]
Stomach Neoplasms
[UFT/CDDP preoperative chemotherapy for progressive gastric cancer--histological antitumor effects and thymidylate synthase inhibition rate]
Stomatitis
Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia.
Stomatitis
Methylenetetrahydrofolate reductase and thymidylate synthase genotypes modify oral mucositis severity following hematopoietic stem cell transplantation.
Stomatitis
The role of genetic polymorphisms in the thymidylate synthase (TYMS) gene in methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia.
Takotsubo Cardiomyopathy
The First Case of Severe Takotsubo Cardiomyopathy Associated with 5-Fluorouracil in a Patient with Abnormalities of Both Dihydropyrimidine Dehydrogenase (DPYD) and Thymidylate Synthase (TYMS) Genes.
Thoracic Neoplasms
¹?F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms.
thymidylate synthase deficiency
Genetic analysis of two mutations affecting thymidine metabolism in Dictyostelium discoideum.
thymidylate synthase deficiency
Isolation of functional cDNA clones for human thymidylate synthase.
thymidylate synthase deficiency
Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency.
Thymoma
Expression of thymidylate synthase and orotate phosphoribosyltransferase in thymic carcinoma.
Thymoma
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in thymoma.
Thymus Neoplasms
Messenger RNA and protein expression of thymidylate synthase and DNA repair genes in thymic tumors.
Tongue Neoplasms
Intratumoural expression of thymidylate synthase is an independent predictor of prognosis in patients with squamous cell carcinoma of the tongue: results from a retrospective study.
Trichinellosis
Binding and repression of translation of the cognate mRNA by Trichinella spiralis thymidylate synthase differ from the corresponding interactions of the human enzyme.
Triple Negative Breast Neoplasms
Multiaction Platinum(IV) Prodrug Containing Thymidylate Synthase Inhibitor and Metabolic Modifier against Triple-Negative Breast Cancer.
Triple Negative Breast Neoplasms
Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy.
Tuberculosis
Analysis of mutations leading to para-aminosalicylic acid resistance in Mycobacterium tuberculosis.
Tuberculosis
Crystallization and preliminary crystallographic studies of a flavin-dependent thymidylate synthase from Helicobacter pylori.
Tuberculosis
dUMP/F-dUMP Binding to Thymidylate Synthase: Human Versus Mycobacterium tuberculosis.
Tuberculosis
Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX.
Tuberculosis
Mycobacterium tuberculosis thymidylate synthase (ThyX) is a target for plumbagin, a natural product with antimycobacterial activity.
Tuberculosis
Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid.
Tuberculosis
Role of mutations in dihydrofolate reductase DfrA (Rv2763c) and thymidylate synthase ThyA (Rv2764c) in Mycobacterium tuberculosis drug resistance.
Tuberculosis
Synthesis and evaluation of C-5 modified 2'-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase.
Tuberculosis
[Mutations in the thymidylate synthase gene is a major mechanism in the para-aminosalicylic acid resistance of M. tuberculosis]
Urinary Bladder Neoplasms
Clinical significance of thymidylate synthase expression in bladder cancer.
Urinary Bladder Neoplasms
Combination studies with 3'-azido-3'-deoxythymidine (AZT) plus ICI D1694. Cytotoxic and biochemical effects.
Urinary Bladder Neoplasms
Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression.
Urinary Bladder Neoplasms
Expression of the fluoropyrimidine-metabolizing enzymes in bladder cancers as measured by the Danenberg tumor profile.
Urinary Bladder Neoplasms
Polymorphisms in one-carbon metabolism pathway genes and risk for bladder cancer in a Tunisian population.
Urinary Bladder Neoplasms
Prognostic significance of a combination of thymidylate synthase and dihydropyrimidine dehydrogenase activities in grades 1 and 2 superficial bladder cancer.
Urinary Bladder Neoplasms
Therapeutic enhancement of S-1 with CPT-11 through down-regulation of thymidylate synthase in bladder cancer.
Urinary Bladder Neoplasms
Thymidylate synthase inhibition induces p53-dependent and p53-independent apoptotic responses in human urinary bladder cancer cells.
Urinary Bladder Neoplasms
Thymidylate synthase was associated with patient prognosis and the response to adjuvant therapy in bladder cancer.
Uterine Cervical Neoplasms
Enhanced expression of thymidylate synthase may be of prognostic importance in advanced cervical cancer.
Uterine Cervical Neoplasms
Enhanced expression of thymidylate synthase mediates resistance of uterine cervical cancer cells to radiation.
Uterine Cervical Neoplasms
Immunohistochemical investigation of thymidylate synthase in cervical cancer.
Uterine Cervical Neoplasms
The HPV16 E6/E7 oncogene sensitizes human ovarian surface epithelial cells to low-dose but not high-dose 5-FU and 5-FUdR.
Uterine Cervical Neoplasms
Thymidylate synthase inhibition as a predictor of tumor sensitivity of fluorinated pyrimidines.
Uterine Cervical Neoplasms
[Relationship between the expression of P-glycoprotein, glutathione S-transferase-pi and thymidylate synthase proteins and adenosine triphosphate tumor chemosensitivity assay in cervical cancer]
Venous Thrombosis
Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis risk.
Venous Thrombosis
Thymidylate synthase genotype and serum concentrations of homocysteine and folate in Behçet's disease.
Vitamin B 12 Deficiency
Evidence against defective thymidylate synthetase being the main biochemical lesion in vitamin B12 deficiency.
Vitamin B 12 Deficiency
Vitamin B12--folate interrelations.
Xeroderma Pigmentosum
Epidermal growth factor receptor intron 1 CA dinucleotide repeat polymorphism and survival of advanced gastric cancer patients treated with cetuximab plus modified FOLFOX6.
Xeroderma Pigmentosum
Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy.
Xeroderma Pigmentosum
Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFOX-4 chemotherapy.
Xeroderma Pigmentosum
Pharmacogenetic Study in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy: Polymorphisms in Thymidylate Synthase, Epidermal Growth Factor Receptor, GSTP1, and DNA Repair Genes.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.