Information on EC 2.1.1.43 - histone-lysine N-methyltransferase

Word Map on EC 2.1.1.43
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)

The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.1.1.43
-
RECOMMENDED NAME
GeneOntology No.
histone-lysine N-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
carnitine metabolism
-
-
Lysine degradation
-
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase
One of a group of enzymes methylating proteins; see also EC 2.1.1.59, [cytochrome-c]-lysine N-methyltransferase and EC 2.1.1.60, calmodulin-lysine N-methyltransferase.
CAS REGISTRY NUMBER
COMMENTARY hide
9055-08-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
strain CAI12
-
-
Manually annotated by BRENDA team
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
1039882 A+, 1094694 A+, 1094696 A+, 1094700 A+, 1094704 A+, 1094712 A+, 1094719 A+, 1094732 A+, 1094756 A+, 1094758 A+, 1094766 A+, 1094785 A+, 1094830 A+, 1094843 A+, 1094870 A+, 1094935 A+, 1094947 A+, 1094953 A+, 1094984 A+, 1094999 A+, 1095053 A+, 1095054 A+, 1229090 A+, 1807425 A+, 1879082 A+, 1879093 A+, 1879116 A+, 1879118 A+, 1879125 A+, 1879134 A+, 1879137 A+, 1879154 A+, 1879189 A+, 1879344 A+, 1879356 A+, 1879409 A+, 1879531 A+, 1879533 A+, 1879569 A+, 1879629 A+, 1879653 A+, 1879698 A+, 1879739 A+, 1879786 A+, 2291772 A+, 2291773 A+, 2291779 A+, 2291809 A+, 2291936 A+, 2291941 A+, 2292014 A+, 2292079 A+, 2292100 A+, 2292132 A+, 2292145 A+, 2292358 A+, 2314867 A+, 2902065 A+, 2902091 A+, 2902139 A+, 2902145 A+, 2902289 A+, 2902329 A+, 2902332 A+, 2902336 A+, 2902348 A+, 2902378 A+, 2902449 A+, 2902456 A+, 2902477 A+, 2902697 A+, 2903040 A+, 2903042 A+, 2903169 A+, 703871 A+, 703940 A+, 717476 A+, 719332 A+, 735186 A+, 1094715 A++, 1094907 A++, 1738699 A++, 1879165 A++, 1879224 A++, 1879262 A++, 1879296 A++, 1879419 A++, 2291872 A++, 2291879 A++, 2291957 A++, 2292060 A++, 2292184 A++, 2902205 A++, 2902282 A++, 2902291 A++, 2902293 A++, 2902452 A++, 2902752 A++, 1094725 A++, 1094726 A++, 1094728 A++, 1094767 A++, 1094770 A++, 1879306 A++, 1879549 A++, 2291787 A++, 2291805 A++, 2291827 A++, 2291877 A++, 2291921 A++, 2292041 A++, 2292059 A++, 2359143 A++, 2902072 A++, 2902146 A++, 2902650 A++, 2902841 A++, 706446 A++, 719306 A++, 721056 A++, 1094701 A+++, 1094708 A+++, 1094711 A+++, 1094722 A+++, 1094781 A+++, 1094841 A+++, 1094880 A+++, 1095078 A+++, 1095085 A+++, 719366 A+++, 719561 A+++, 1094738 A++++, 1094744 A++++, 1094786 A++++, 1094931 A++++, 661834 A++++, 703868 A++++
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
1094838 A+, 1094868 A+, 1094893 A+, 1094932 A+, 1094957 A+, 1094961 A+, 1094969 A+, 1094991 A+, 1095000 A+, 1095005 A+, 1095018 A+, 1095031 A+, 1095049 A+, 1095053 A+, 1095061 A+, 1339438 A+, 1878715 A+, 1879236 A+, 1879391 A+, 1879439 A+, 1879507 A+, 1879563 A+, 1879585 A+, 1879622 A+, 1879641 A+, 1879762 A+, 1879785 A+, 2289429 A+, 2291885 A+, 2291903 A+, 2291941 A+, 2291942 A+, 2291946 A+, 2291967 A+, 2292018 A+, 2292027 A+, 2292091 A+, 2292128 A+, 2292133 A+, 2292173 A+, 2292228 A+, 2292235 A+, 2292237 A+, 2292240 A+, 2292285 A+, 2292326 A+, 2292329 A+, 2292352 A+, 2292358 A+, 2292360 A+, 2292362 A+, 2292370 A+, 2292377 A+, 2292404 A+, 2729564 A+, 2776767 A+, 2902335 A+, 2902396 A+, 2902407 A+, 2902442 A+, 2902470 A+, 2902493 A+, 2902535 A+, 2902594 A+, 2902624 A+, 2902641 A+, 2902652 A+, 2902757 A+, 2902825 A+, 2902830 A+, 2902988 A+, 2903036 A+, 2903082 A+, 2903134 A+, 704436 A+, 706408 A+, 734756 A+, 1004300 A++, 1094739 A++, 1094767 A++, 1094799 A++, 1094922 A++, 1095045 A++, 1229034 A++, 1382504 A++, 1879273 A++, 1879311 A++, 1879321 A++, 1879326 A++, 1879631 A++, 1879720 A++, 1879731 A++, 2291822 A++, 2291841 A++, 2291849 A++, 2291858 A++, 2291879 A++, 2291925 A++, 2292096 A++, 2292135 A++, 2292138 A++, 2292146 A++, 2292204 A++, 2292250 A++, 2292261 A++, 2292274 A++, 2315747 A++, 2794050 A++, 2901553 A++, 2902110 A++, 2902215 A++, 2902224 A++, 2902250 A++, 2902284 A++, 2902341 A++, 2902346 A++, 2902383 A++, 2902526 A++, 2902555 A++, 2902557 A++, 2902612 A++, 2902689 A++, 2902740 A++, 2902773 A++, 2902828 A++, 2902921 A++, 2902925 A++, 485353 A++, 1094828 A++, 1094833 A++, 1094850 A++, 1094936 A++, 1094975 A++, 1095033 A++, 1095037 A++, 1095038 A++, 1879481 A++, 2291810 A++, 2291883 A++, 2291921 A++, 2292202 A++, 2292265 A++, 2292266 A++, 2292269 A++, 2292276 A++, 2292286 A++, 2902296 A++, 2902960 A++, 2902962 A++, 2903013 A++, 704942 A++, 1094776 A+++, 1094846 A+++, 1094935 A+++, 1094965 A+++, 1094983 A+++, 1095083 A+++, 951325 A+++, 1095074 A++++
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
Trypanosoma brucei Lister 427
strain Lister 427
-
-
Manually annotated by BRENDA team
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
-
-
-
Automatic Mining of ENzyme DAta
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ARTKQTARKSTGGKAPRK(biot)G + S-adenosyl-L-methionine
ART-methyl-KQTARKSTGGKAPRK(biot)G + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
biotinyl-MARTKQTARKSTGGKAPRKQ + S-adenosyl-L-methionine
?
show the reaction diagram
-
Dim-5 methylates the histone H3 tail at position Lys9
-
-
-
MC-1alpha + S-adenosyl-L-methionine
MC-1alpha N6-methylated at lysine37 + S-adenosyl-L-homocysteine
show the reaction diagram
-
high substrate specificity
-
-
?
polylysine + S-adenosylmethionine
S-adenosyl-L-homocysteine + N6-methylpolylysine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-aminohexanoyl-GSRAHSSHLKSKKGQSTSRH
?
show the reaction diagram
-
100% activity
-
-
?
S-adenosyl-L-methionine + biotin-ARTKQTARKST
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + CDYL1 protein
?
show the reaction diagram
-
target of histone lysine methyltransferase G9a (KMT1C)
-
-
?
S-adenosyl-L-methionine + chicken nucleosome
S-adenosyl-L-homocysteine + chicken nucleosome N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + CSB protein
?
show the reaction diagram
-
target of histone lysine methyltransferase G9a (KMT1C)
-
-
?
S-adenosyl-L-methionine + dimethylated histone H3(K9)
S-adenosyl-L-homocysteine + trimethylated histone H3(K9)
show the reaction diagram
-
the activity on dimethylated histone H3(K9) peptides is several folds lower than when monomethylated histone H3(K9) peptides are used
-
-
?
S-adenosyl-L-methionine + DNA methyltransferase 1
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + estrogen receptor alpha(K302)
?
show the reaction diagram
estrogen receptor alpha is directly methylated at lysine-302 by SET-7, a K303R mutation inhibits methylation at K302 in vivo
-
-
?
S-adenosyl-L-methionine + HDAC1 protein
?
show the reaction diagram
-
target of histone lysine methyltransferase G9a (KMT1C)
-
-
?
S-adenosyl-L-methionine + histone (K4)
S-adenosyl-L-homocysteine + methylated histone (K4)
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone 3(K4)
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone 3(K79)
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H1
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H1.4(K121)
?
show the reaction diagram
-
less than 10% methylation at Lys-34
-
-
?
S-adenosyl-L-methionine + histone H1.4(K26)
?
show the reaction diagram
-
70% methylation at Lys-26, methylation of the K26A mutant of histone H1.4 is strongly reduced but not completely abolished
-
-
?
S-adenosyl-L-methionine + histone H1.4(K34)
?
show the reaction diagram
-
10-15% methylation at Lys-34
-
-
?
S-adenosyl-L-methionine + histone H1.4(K52)
?
show the reaction diagram
-
less than 1% methylation at Lys-34
-
-
?
S-adenosyl-L-methionine + histone H2A
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H2A
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H2B
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H2B
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H2B L-lysine
S-adenosyl-L-homocysteine + histone H2B N6-methyl-L-lysine
show the reaction diagram
-
about 150% activity compared to biotin-aminohexanoyl-GSRAHSSHLKSKKGQSTSRH, H2B is more efficient substrate with 3fold higher specific activity compared to H3
-
-
?
S-adenosyl-L-methionine + histone H3
?
show the reaction diagram
S-adenosyl-L-methionine + histone H3 (1-13)
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H3 (S10phos)
?
show the reaction diagram
-
phosphorylation of the proximal amino acids impairs Lys-9 methylation via impairing enzyme-substrate interaction
-
-
?
S-adenosyl-L-methionine + histone H3 (T11phos)
?
show the reaction diagram
-
phosphorylation of the proximal amino acids impairs Lys-9 methylation via impairing enzyme-substrate interaction
-
-
?
S-adenosyl-L-methionine + histone H3 L-lysine
S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine
show the reaction diagram
-
efficient substrate, about 40% activity compared to biotin-aminohexanoyl-GSRAHSSHLKSKKGQSTSRH
-
-
?
S-adenosyl-L-methionine + histone H3 lysine 36
?
show the reaction diagram
dimethylation
-
-
?
S-adenosyl-L-methionine + histone H3(K27)
?
show the reaction diagram
S-adenosyl-L-methionine + histone H3(K27)
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H3(K27)
S-adenosyl-L-homocysteine + N-methylated histone H3(K27)
show the reaction diagram
S-adenosyl-L-methionine + histone H3(K27)
S-adenosyl-L-homocysteine + N6-methylated histone H3(K27)
show the reaction diagram
-
-
isoforms NSD1, NSD2 and NSD3, mainly trimethylation
-
?
S-adenosyl-L-methionine + histone H3(K27A)
?
show the reaction diagram
-
mutation in the unstructured amino-terminal tail of histone H3 does not affect the central globular domain, but reduces the turnover numbers of the substrates
-
-
?
S-adenosyl-L-methionine + histone H3(K36)
?
show the reaction diagram
S-adenosyl-L-methionine + histone H3(K36)
S-adenosyl-L-homocysteine + histone H3(K36) N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + histone H3(K36)
S-adenosyl-L-homocysteine + N-methylated histone H3(K36)
show the reaction diagram
S-adenosyl-L-methionine + histone H3(K36)
S-adenosyl-L-homocysteine + N6-methylated histone H3(K36)
show the reaction diagram
-
-
preferable in vitro substrate for isoform NSD1
-
?
S-adenosyl-L-methionine + histone H3(K36R)
?
show the reaction diagram
-
methylated by GST-mG9a
-
-
?
S-adenosyl-L-methionine + histone H3(K4)
?
show the reaction diagram
S-adenosyl-L-methionine + histone H3(K4)
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
enzyme G9A exhibits a modest decrease in catalytic efficiency when assayed with an histone H3(K4)me3 peptide in comparison to an unmodified H3 peptide substrate
-
-
?
S-adenosyl-L-methionine + histone H3(K4)
S-adenosyl-L-homocysteine + N-methylated histone H3(K4)
show the reaction diagram
S-adenosyl-L-methionine + histone H3(K4)
S-adenosyl-L-homocysteine + N6-methylated histone H3(K4)
show the reaction diagram
-
-
isoforms NSD1 and NSD2, mainly trimethylation
-
?
S-adenosyl-L-methionine + histone H3(K4A)
?
show the reaction diagram
-
mutation in the unstructured amino-terminal tail of histone H3 does not affect the central globular domain, but reduces the turnover numbers of the substrates
-
-
?
S-adenosyl-L-methionine + histone H3(K76)
?
show the reaction diagram
S-adenosyl-L-methionine + histone H3(K79)
?
show the reaction diagram
S-adenosyl-L-methionine + histone H3(K79)
S-adenosyl-L-homocysteine + N6-methylated histone H3(K79)
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H3(K9)
?
show the reaction diagram
S-adenosyl-L-methionine + histone H3(K9)
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + histone H3(K9)
S-adenosyl-L-homocysteine + N6-methylated histone H3(K9)
show the reaction diagram
-
-
isoforms NSD1, NSD2 and NSD3, mainly dimethylation
-
?
S-adenosyl-L-methionine + histone H3(N)
?
show the reaction diagram
S-adenosyl-L-methionine + histone H3(N27)
?
show the reaction diagram
S-adenosyl-L-methionine + histone H3(N4)
?
show the reaction diagram
methylated by GST-HYPB protein
-
-
?
S-adenosyl-L-methionine + histone H3(N9)
?
show the reaction diagram
S-adenosyl-L-methionine + histone H3(peptide 21-44)
S-adenosyl-L-homocysteine + histone H3(peptide21-44) N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + histone H3(peptide31-50)
S-adenosyl-L-homocysteine + N6-methylated K36 in histone H3(peptide 31-50)
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H3.2 L-lysine
S-adenosyl-L-homocysteine + histone H3.2 N6-methyl-L-lysine
show the reaction diagram
-
about 30% activity compared to biotin-aminohexanoyl-GSRAHSSHLKSKKGQSTSRH
-
-
?
S-adenosyl-L-methionine + histone H4
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H4
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone H4
S-adenosyl-L-homocysteine + N-methylated histone H4
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + histone H4 L-lysine
S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine
show the reaction diagram
-
best substrate, H4 is more efficient substrate with 5fold higher specific activity compared to H3, about 240% activity compared to biotin-aminohexanoyl-GSRAHSSHLKSKKGQSTSRH
-
-
?
S-adenosyl-L-methionine + histone H4(K20)
?
show the reaction diagram
S-adenosyl-L-methionine + histone H4(K20)
S-adenosyl-L-homocysteine + N6-methylated histone H4(K20)
show the reaction diagram
-
-
isoform NSD1, mainly mono- and trimethylation, isoforms NSD2 and NSD3, mainly di-and trimethylation
-
?
S-adenosyl-L-methionine + histone H4(K344)
?
show the reaction diagram
histone H4 lysine-44 is the primary target of NSD2 in the case of octamer substrates, irrespective of the histones being native or recombinant
-
-
?
S-adenosyl-L-methionine + histone H4(peptide35-55)
S-adenosyl-L-homocysteine + N6-methylated K44 in histone H4(peptide 35-55)
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone K4-acetylK9
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone K4-trimethylK9
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone K4AK9
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + histone L-lysine
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
show the reaction diagram
S-adenosyl-L-methionine + monomethylated histone H3(K9)
S-adenosyl-L-homocysteine + trimethylated histone H3(K9)
show the reaction diagram
-
the SUVR4 product specificity shifts from di- to trimethylation in the presence of free ubiquitin. SUVR4 in vivo specifically converts monomethylated histone H3(K9) to trimethylated histone H3(K9) at transposons and pseudogenes
-
-
?
S-adenosyl-L-methionine + p300/CBP-associated factor
?
show the reaction diagram
-
K78 and K89 are preferentially methylated in full-length p300/CBP-associated factor in vitro
-
-
?
S-adenosyl-L-methionine + p53
?
show the reaction diagram
S-adenosyl-L-methionine + p53 (K382)
?
show the reaction diagram
-
SET8 activity is strongly reduced by the arginine methylation at position R379
-
-
?
S-adenosyl-L-methionine + p53 protein
S-adenosyl-L-homocysteine + N-methylated p53 protein
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + p53(K373)
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + p53(K373)
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + recombinant nucleosome
S-adenosyl-L-homocysteine + recombinant nucleosome N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + TAF10-K189 peptide
?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + transcriptional factor p53
?
show the reaction diagram
-
methylation of transcriptional factor p53 with the sequence LKSKKGQSTY occurs at Lys-4
-
-
?
S-adenosyl-L-methionine + transition protein TP2
S-adenosyl-L-homocysteine + N6-methylated transition protein TP2
show the reaction diagram
-
-
enzyme methylates TP2 at Lys88 and Lys91 residues. TP2K88me1 modifications appear in elongating to condensing spermatids and are predominantly associated with the chromatin-bound TP2
-
?
S-adenosyl-L-methionine + WIZ protein
?
show the reaction diagram
-
target of histone lysine methyltransferase G9a (KMT1C)
-
-
?
S-adenosyl-L-methionine + [primase-subunit-Pri1]-L-lysine
S-adenosyl-L-homocysteine + [primase-subunit-Pri1]-N6-methyl-L-lysine
show the reaction diagram
S-adenosyl-L-methionine + [primase-subunit-Pri2]-L-lysine
S-adenosyl-L-homocysteine + [primase-subunit-Pri2]-N6-methyl-L-lysine
show the reaction diagram
S-adenosyl-L-methionine + [protein Cren7]-L-lysine
S-adenosyl-L-homocysteine + [protein Cren7]-N6-methyl-L-lysine
show the reaction diagram
S-adenosyl-L-methionine + [protein Dpo4]-L-lysine
S-adenosyl-L-homocysteine + [protein Dpo4]-N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [protein FEN1]-L-lysine
S-adenosyl-L-homocysteine + [protein FEN1]-N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [protein GINS15]-L-lysine
S-adenosyl-L-homocysteine + [protein GINS15]-N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [protein PCNA1]-L-lysine
S-adenosyl-L-homocysteine + [protein PCNA1]-N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [protein PCNA2]-L-lysine
S-adenosyl-L-homocysteine + [protein PCNA2]-N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [protein PolB1]-L-lysine
S-adenosyl-L-homocysteine + [protein PolB1]-N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [protein Sso7d2]-L-lysine
S-adenosyl-L-homocysteine + [protein Sso7d2]-N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [ribosomal protein L11]-L-lysine
S-adenosyl-L-homocysteine + [ribosomal protein L11]-N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [Topo-III]-L-lysine
S-adenosyl-L-homocysteine + [Topo-III]-N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
additional information
?
-