Information on EC 2.1.1.40 - inositol 1-methyltransferase

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The expected taxonomic range for this enzyme is: Gunneridae

EC NUMBER
COMMENTARY
2.1.1.40
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RECOMMENDED NAME
GeneOntology No.
inositol 1-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-1-O-methyl-myo-inositol
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
methyl group transfer
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Inositol phosphate metabolism
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase
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SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
inositol 3-O-methyltransferase
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-
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inositol D-1-methyltransferase
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-
-
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methyltransferase, inositol, D-1-
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myo-inositol 3-O-methyltransferase
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S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase
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S-adenosylmethionine:myo-inositol 3-methyltransferase
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S-adenosylmethionine:myo-inositol 3-O-methyltransferase
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-
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CAS REGISTRY NUMBER
COMMENTARY
37257-06-0
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
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transgenic tobacco plants co-expressing INO1 and IMT1 gene either in cytosol or in chloroplasts accumulate higher amount of total inositol (free and methyl inositol) compared to nontransgenic plants. These plants are more competent in terms of growth potential and photosynthetic activity and are less prone to oxidative stress under salt stress
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-bornesitol + S-adenosyl-L-methionine
1,3-di-O-methyl-myo-inositol + S-adenosyl-L-homocysteine
show the reaction diagram
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low reaction rate
-
-
?
D-chiro-inositol + S-adenosyl-L-methionine
quebrachitol + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
?
L-bornesitol + S-adenosyl-L-methionine
1,3-di-O-methyl-myo-inositol + S-adenosyl-L-homocysteine
show the reaction diagram
-
low reaction rate
-
-
?
L-chiro-inositol + S-adenosyl-L-methionine
quebrachitol + pinitol + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + myo-inositol
S-adenosyl-L-homocysteine + D-bornesitol
show the reaction diagram
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-
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S-adenosyl-L-methionine + myo-inositol
S-adenosyl-L-homocysteine + D-bornesitol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + myo-inositol
S-adenosyl-L-homocysteine + D-bornesitol
show the reaction diagram
-
biosynthesis of cyclitols
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-
?
scyllo-inositol + S-adenosyl-L-methionine
?
show the reaction diagram
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low reaction rate
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-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + myo-inositol
S-adenosyl-L-homocysteine + D-bornesitol
show the reaction diagram
-
biosynthesis of cyclitols
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-
?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
iodoacetamide
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N-ethylmaleimide
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p-chloromercuribenzoate
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2.3
myo-Inositol
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2.9
myo-Inositol
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2.5
S-adenosyl-L-methionine
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3.2
S-adenosyl-L-methionine
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-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.0078
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kat/g
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.7 - 7.6
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about 50% of activity maximum at pH 6.7 and 7.6
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
30000
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gel filtration
485318
42000
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gel filtration, PAGE
485319
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
monomer
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1 * 42000, SDS-PAGE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
3
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24 h, 40% loss of activity
485318
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
glutathione stabilizes slightly
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Nicotiana tabacum
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