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Information on EC 2.1.1.37 - DNA (cytosine-5-)-methyltransferase and Organism(s) Bos taurus and UniProt Accession Q24K09

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.37 DNA (cytosine-5-)-methyltransferase
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This record set is specific for:
Bos taurus
UNIPROT: Q24K09 not found.
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The enzyme appears in selected viruses and cellular organisms
Synonyms
dnmt1, dnmt3a, dna methyltransferase, dnmt3b, dna methyltransferase 1, dnmt2, dna mtase, nsun2, dna methylase, dna methyltransferase 3a, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
DNA methyltransferase-1
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C5-MTase
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-
-
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cytosine 5-methyltransferase
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-
-
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cytosine DNA methylase
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-
-
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cytosine DNA methyltransferase
-
-
-
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cytosine-specific DNA methyltransferase
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-
-
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DCMT
-
-
-
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deoxyribonucleate methylase
-
-
-
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deoxyribonucleate methyltransferase
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-
-
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deoxyribonucleic (cytosine-5-)-methyltransferase
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-
-
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deoxyribonucleic acid (cytosine-5-)-methyltransferase
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-
-
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deoxyribonucleic acid methylase
-
-
-
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deoxyribonucleic acid methyltransferase
-
-
-
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deoxyribonucleic acid modification methylase
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-
-
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deoxyribonucleic methylase
-
-
-
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DNA 5-cytosine methylase
-
-
-
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DNA cytosine c5 methylase
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-
-
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DNA cytosine methylase
-
-
-
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DNA methylase
-
-
-
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DNA methyltransferase
-
-
-
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DNA transmethylase
-
-
-
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DNA-cytosine 5-methylase
-
-
-
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DNA-cytosine methyltransferase
-
-
-
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EcoRI methylase
-
-
-
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methylphosphotriester-DNA methyltransferase
-
-
-
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methyltransferase, deoxyribonucleate
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-
-
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type II DNA methylase
-
-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
show the reaction diagram
random sequential mechanism
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
-
-
-
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9037-42-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
S-adenosyl-L-methionine
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
native DNA
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non-competitive inhibitor against S-adenosyl-L-methionine
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S-adenosyl-L-ethionine
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non-competitive inhibitor against DNA
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
female cows
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
during differentiation, Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes but enters the nuclei of 8-16 cell stage embryos
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
during differentiation, Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes but enters the nuclei of 8-16 cell stage embryos
Manually annotated by BRENDA team
during differentiation, Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes but enters the nuclei of 8-16 cell stage embryos
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
Dnmt1 is involved in DNA methylation pattern regulation during the late stage oocyte differentiation, maturation and early embryonic development, overview
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DNMT1_BOVIN
1611
0
182842
Swiss-Prot
Mitochondrion (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
130000
-
glycerol density gradient centrifugation
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, enzyme loses activity within several weeks
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
partial
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression analysis by RT-PCR
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sano, H.; Noguchi, H.; Sager, R.
Characterization of DNA methyltransferase from bovine thymus cells
Eur. J. Biochem.
135
181-185
1983
Bos taurus
Manually annotated by BRENDA team
Lodde, V.; Modina, S.C.; Franciosi, F.; Zuccari, E.; Tessaro, I.; Luciano, A.M.
Localization of DNA methyltransferase-1 during oocyte differentiation, in vitro maturation and early embryonic development in cow
Eur. J. Histochem.
53
199-208
2009
Bos taurus (Q24K09), Bos taurus
Manually annotated by BRENDA team