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Information on EC 2.1.1.37 - DNA (cytosine-5-)-methyltransferase and Organism(s) Homo sapiens and UniProt Accession P26358
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2.1.1.37 DNA (cytosine-5-)-methyltransferaseSpecify your search results
Word Map
- 2.1.1.37
- histone
- methyltransferases
- cpg
-
hypermethylation
-
demethylation
- chromatin
- leukemia
- myeloid
- deacetylase
-
dnmts
- 5-aza-2'-deoxycytidine
- bisulfite
- tumorigenesis
- carcinogenesis
- 5-azacytidine
-
methylation-specific
-
hematopoietic
-
myelodysplastic
-
imprint
-
unmethylated
- 5-methylcytosine
- mtases
- decitabine
- hdacs
- endonuclease
- hematologic
-
cytogenetic
-
epigenome
-
pluripotent
-
restriction-modification
-
methylome
-
trimethylation
-
trichostatin
- blastocyst
-
re-expression
- heterochromatin
- o6-methylguanine
-
centromeric
-
nanog
- p16ink4a
- cdh1
-
flt3-itd
- adomet
-
polycomb
-
methylation-sensitive
-
leukemogenesis
-
rassf1a
-
h3k9me3
- biotechnology
-
line-1
- hpaii
- drug development
- analysis
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
dnmt1, dnmt3a, dna methyltransferase, dnmt3b, dna methyltransferase 1, dnmt2, dna mtase, nsun2, dna methylase, dna methyltransferase 3a, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Dnmt1
C5-MTase
-
-
-
-
cytosine 5-methyltransferase
-
-
-
-
cytosine DNA methylase
-
-
-
-
cytosine DNA methyltransferase
-
-
-
-
cytosine-specific DNA methyltransferase
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-
-
-
DCMT
-
-
-
-
deoxyribonucleate methylase
-
-
-
-
deoxyribonucleate methyltransferase
-
-
-
-
deoxyribonucleic (cytosine-5-)-methyltransferase
-
-
-
-
deoxyribonucleic acid (cytosine-5-)-methyltransferase
-
-
-
-
deoxyribonucleic acid methylase
-
-
-
-
deoxyribonucleic acid methyltransferase
-
-
-
-
deoxyribonucleic acid modification methylase
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-
-
-
deoxyribonucleic methylase
-
-
-
-
DNA 5-cytosine methylase
-
-
-
-
DNA cytosine c5 methylase
-
-
-
-
DNA cytosine methylase
-
-
-
-
DNA methylase
-
-
-
-
DNA methyltransferase
DNA transmethylase
-
-
-
-
DNA-cytosine 5-methylase
-
-
-
-
DNA-cytosine methyltransferase
-
-
-
-
DNMT
Dnmt3a
DNMT3B
EcoRI methylase
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-
-
-
methylphosphotriester-DNA methyltransferase
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-
-
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methyltransferase, deoxyribonucleate
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-
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type II DNA methylase
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-
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additional information
DNA methyltransferase
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-
-
-
additional information
-
the enzyme belongs to the DNA methyltransferase, DNMT, enzyme family
additional information
-
the enzyme belongs to the DNA methyltransferases, Dnmt, family of enzymes that methylates DNA at the C5 position of cytosine residues
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
catalytic reaction mechanism of Dnmt1, overview
-
S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
sequential mechanism
S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
catalytic reaction mechanism of Dnmt1, allosteric regulation with fast equilibrium, and substrate specificity. Base-flipping and base-stacking are the key mechanism in control of enzymatic activity, detailed overview
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
methyl group transfer
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase
-
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CAS REGISTRY NUMBER
COMMENTARY
9037-42-7
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + (CMeGG-CCG)12
S-adenosyl-L-homocysteine + (CMeGG-CCG)12 containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + linear pRW 3602 DNA containing cytosine
S-adenosyl-L-homocysteine + linear pRW 3602 DNA containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + mononucleosomal DNA containing cytosine
S-adenosyl-L-homocysteine + mononucleosomal DNA containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + poly (dI-dC)
S-adenosyl-L-homocysteine + poly (dI-dC) containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + relaxed circular pRW 3602 DNA containing cytosine
S-adenosyl-L-homocysteine + relaxed circular pRW 3602 DNA containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + supercoiled pRW 3602 DNA containing cytosine
S-adenosyl-L-homocysteine + supercoiled pRW 3602 DNA containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
S-adenosyl-L-methionine + Micrococcus luteus DNA containing cytosine
S-adenosyl-L-homocysteine + Micrococcus luteus DNA containing 5-methylcytosine
-
-
-
-
?
S-adenosyl-L-methionine + mononucleosomal DNA containing cytosine
S-adenosyl-L-homocysteine + mononucleosomal DNA containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + native Micrococcus lysodeikticus DNA containing cytosine
S-adenosyl-L-homocysteine + native Micrococcus lysodeikticus DNA containing 5-methylcytosine
-
-
-
-
?
S-adenosyl-L-methionine + P815 DNA containing cytosine
S-adenosyl-L-homocysteine + P815 DNA containing 5-methylcytosine
-
-
-
-
?
S-adenosyl-L-methionine + poly(dI-dC)/poly(dI-dC)
S-adenosyl-L-homocysteine + poly(dI-dC)/poly(dI-dC) containing 5-methylcytosine
-
-
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
DNA cytosine methylation is one of the major epigenetic gene silencing marks in the human genome facilitated by DNA methyltransferases
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
Dnmt1 methylates DNA at CG sites. Substrate binding and involved motifs in Dnmt1, overview
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
poly(dI-dC) substrate DNA. The enzyme contains the zinc-finger CXXC domain, a zinc-coordinating domain that selectively binds unmethylated DNA and is crucial for enzymatic activity
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
DNA topology strongly influences the reaction rate, which increases with increasing negative superhelical tension
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
DNMT1 interacts with hSNF2H chromatin remodeling enzyme and binds mononucleosomes with higher affinity in the presence of hSNF2H
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
control of Dnmt1, the predominant maintainance methyltransferase, is significantly suppressed in aging cells and contributes to the reduced genomic methylation of these cells. The paradoxical sporadic gene hypermethylation in aging cells appears to be related to transcriptional up-regulation of the Dnmt3b gene. Changes in transcriptional control of the Dnmts are the likely cause for the known alterations in DNA methylation in aging cells and in cells undergoing tumorigenesis
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
free DNA or assembled into a mononucleosome. The catalytic efficiency decreases on the mononucleosome 8fold
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
the enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine onto the 5'-position of the cytosine ring of the DNA
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
-
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
both DNMT3A and DNMT3B are involved in de novo DNA methylation. 5'-Cytosine methylation is a common epigenetic modification in eukaryotic genomes
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
double-stranded DNA substrates with CpG site containing 8-oxo-7,8-dihydroguanine, resulting in diminished enzymatic methylation of its 5' neighboring cytosine, or 8-oxoG or O6-methylguanine in the CpG site, overview
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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a hemimethylated 5MeCpG target site is generated using Sau3AI restriction enzyme
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
the enzyme is able to methylate homologues HeLa DNA, altough to a lesser extent than heterologous DNA. The enzyme can methylate single-stranded DNA three times higher than that of the corresponding double-stranded DNA, the 5' neighbor can be either G or C while the 3' neighbor is always G, enzyme can methylate poly(dG,dC)
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
methylation of double-stranded Micrococcus luteus DNA. The enzyme transfers methyl groups to both double-stranded and single-stranded natural DNAs. The methyl-accepting activity of the DNA is correlated to their GC content, homologous DNAs are poor substrates. Very low rate of methylation with poly[(dA-dC)*(dG-dT)], highest methyl-accepting ability with poly[(dG-dC)*(dG-dC)]
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
the enzyme methylates DNA from various sources in native and heat-denatured forms. The synthetic copolymer poly(dG-dC)*poly(dG-dC) is methylated in B-conformation and in Z-conformation to about the same extent, determination of maintenance DNA methylase activity with P815 DNA and determination of de novo DNA methylase activity with 5-methylcytosine-free procaryotic DNA
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
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methylation of a series of snapback oligodeoxynucleotides of differing stem length, each containing a centrally located CG dinucleotide recognition site. The enzyme requires a minimum of 22 base pairs in the stem for maximum activity. Extrahelical cytosines in slipped duplexes that are 30 base pairs in length act as effective methyl acceptors and are more rapidly methylated than cytosines that are Watson-Crick paired. Duplexes containing hairpins of CCG repeats in cruciform structures in which the enzyme recognition sequence is disrupted by a C-C mispair are also more rapidly methylated than the control Watson-Crick-paired duplexes
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
poly(dI-dC)*poly(dI-dC) and unmethylated and hemimethylated 36-mer and 75-mer oligonucleotides. The preference of the enzyme for hemimethylated, over unmethylated DNA is 7-21fold. Poly(dI-dC)poly(dI-dC)
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
DNMT3B interacts with several components of the condensin complex (hCAP-C,hCAP-E and hCAP-G) and KIF4A. Condensin mediates genome-wide chromosome condensation at the onset of mitosis and is critical for proper segregation of sister chromatids. KIF4A is proposed to be a motor protein carrying DNA as cargo. DNMT3B also interacts with histone deacetylase 1 (HDAC1), the co-repressor SIN3A and the ATP-dependent chromatin remodeling enzyme hSNF2H. DNMT3B co-localizes with condensin and KIF4A on condensed chromosomes throughout mitosis, direct link between the machineries regulating DNA methylation and mitotic chromosome condensation. DNMT3B may have a previously unrecognized function during the mitotic phase of the cell cycle
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
hypermethylation of CpG islands in the promoter regions is an important mechanism to silence the expression of many important genes in cancer
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
control of Dnmt1, the predominant maintainance methyltransferase, is significantly suppressed in aging cells and contributes to the reduced genomic methylation of these cells. The paradoxical sporadic gene hypermethylation in aging cells appears to be related to transcriptional up-regulation of the Dnmt3b gene. Changes in transcriptional control of the Dnmts are the likely cause for the known alterations in DNA methylation in aging cells and in cells undergoing tumorigenesis
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
free DNA or assembled into a mononucleosome. The catalytic efficiency decreases on the mononucleosome 17fold
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
methylation is observed at CG sites in a loose ttnCGga(g/a) consensus sequence
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
poly-(dI-dC)/poly(dI-dC), wild-type enzyme and N-terminal deletion mutants lacking 121, 501, 540, or 580 amino acids from the N-terminus methylate CG sequences, prefer hemimethylated to unmethylated DNA
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
the enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine onto the 5 position of the cytosine ring of the DNA
-
-
?
additional information
?
-
role of the enzyme in maintaining the methylation patterns throughout development, the enzyme may be involved in the etiology of fragile X, a syndrome characterized by de novo methylation of a greatly expanded CGG-CCG triplet repeat sequence
-
-
?
additional information
?
-
-
role of the enzyme in maintaining the methylation patterns throughout development, the enzyme may be involved in the etiology of fragile X, a syndrome characterized by de novo methylation of a greatly expanded CGG-CCG triplet repeat sequence
-
-
?
additional information
?
-
no activity with single-stranded DNA with one Cm5 site, double-stranded fully methylated DNA, and poly(dA)-poly(T), pol(G), poly(dC)-poly(dG) or poly(dA-dT)
-
-
?
additional information
?
-
-
upon activation of ER-target gene expression, CpG dinucleotides of promoters undergo cyclical demethylation and remethylation with a cycle time of roughly 2 h, cyclical recruitment of DNMT3A and DNMT3B DNA methyltransferases to the promoter regions of estrogen receptoralpha target genes. In cancer cells, DNMT3A and DNMT3B might posses deaminase activity and be involved in a dynamic demethylation-methylation pathway that operates during gene transcription, overview
-
-
?
additional information
?
-
-
homology docking and molecular dynamics, overview
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
DNA cytosine methylation is one of the major epigenetic gene silencing marks in the human genome facilitated by DNA methyltransferases
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
DNMT1 interacts with hSNF2H chromatin remodeling enzyme and binds mononucleosomes with higher affinity in the presence of hSNF2H
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
the enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine onto the 5'-position of the cytosine ring of the DNA
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
-
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
both DNMT3A and DNMT3B are involved in de novo DNA methylation. 5'-Cytosine methylation is a common epigenetic modification in eukaryotic genomes
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
DNMT3B interacts with several components of the condensin complex (hCAP-C,hCAP-E and hCAP-G) and KIF4A. Condensin mediates genome-wide chromosome condensation at the onset of mitosis and is critical for proper segregation of sister chromatids. KIF4A is proposed to be a motor protein carrying DNA as cargo. DNMT3B also interacts with histone deacetylase 1 (HDAC1), the co-repressor SIN3A and the ATP-dependent chromatin remodeling enzyme hSNF2H. DNMT3B co-localizes with condensin and KIF4A on condensed chromosomes throughout mitosis, direct link between the machineries regulating DNA methylation and mitotic chromosome condensation. DNMT3B may have a previously unrecognized function during the mitotic phase of the cell cycle
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
hypermethylation of CpG islands in the promoter regions is an important mechanism to silence the expression of many important genes in cancer
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
the enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine onto the 5 position of the cytosine ring of the DNA
-
-
?
additional information
?
-
role of the enzyme in maintaining the methylation patterns throughout development, the enzyme may be involved in the etiology of fragile X, a syndrome characterized by de novo methylation of a greatly expanded CGG-CCG triplet repeat sequence
-
-
?
additional information
?
-
-
role of the enzyme in maintaining the methylation patterns throughout development, the enzyme may be involved in the etiology of fragile X, a syndrome characterized by de novo methylation of a greatly expanded CGG-CCG triplet repeat sequence
-
-
?
additional information
?
-
-
upon activation of ER-target gene expression, CpG dinucleotides of promoters undergo cyclical demethylation and remethylation with a cycle time of roughly 2 h, cyclical recruitment of DNMT3A and DNMT3B DNA methyltransferases to the promoter regions of estrogen receptoralpha target genes. In cancer cells, DNMT3A and DNMT3B might posses deaminase activity and be involved in a dynamic demethylation-methylation pathway that operates during gene transcription, overview
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(N4-fluoroacetyl-5-azacytidine)
efficient inhibitor of DNA methylation in human tumor cell lines
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
-
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
-
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
-
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methoxy-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
-
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methyl-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
-
2-amino-4-[([(2S,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-3,4-dihydroxytetrahydrofuran-2-yl]methyl)sulfanyl]butanoic acid
-
2-pyrimidinone
forms a part of inhibitor 1,2-dihydropyrimidin-2-one-5-methylene-(methylsulfonium)-adenosyl, bindng structure and mechanism, overview
miR-127-3p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
miR-145-5p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
miR-146a-5p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
miR-16-5p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
miR-17-5p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
miR-19b-3p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
miR-20a-5p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
miR-21-5p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
miR-373-5p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
miR-9-3p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
miR-9-5p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
miR-92-1-5p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
miR-92a-1-5p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
miR-92a-3p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
[1,2-dihydropyrimidin-2-one]-5-methylene-(methylsulfonium)-adenosyl
with 2-pyrimidinone ring
(-)-epigallocatechin-3-gallate
-
competitive, the inhibitor can form hydrogen bonds with Pro1223, Glu1265, Cys1225, Ser1229 and Arg1309. Hypermethylation of CpG islands in the promoter regions is an important mechanism to silence the expression of many important genes in cancer. (-)-Epigallocatechin-3-gallate can inhibit DNMT activity and reactivate methylation-silenced genes in cancer cells
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
-
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
-
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
-
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methyl-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
-
2-amino-4-[([(2S,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-3,4-dihydroxytetrahydrofuran-2-yl]methyl)sulfanyl]butanoic acid
-
6-thioguanine
-
incorporation of 6-thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Presence of 6-thioguanine at the unmethylated CpG site abolished almost completely the methylation of its 5' adjacent cytosine by DNMT1
retinoblastoma gene product
-
a negative regulator of DNA methylation, binds to the allosteric site of hDNMT1 and inhibits methylation, it may regulate methylation spreading
-
miR-155-5p
micro-RNA, competitive with respect to substrate (CMeGG-CCG)12
-
miR-155-5p
micro-RNA. Exogenous miR-155-5p in cells inhibits DNMT1 and induces aberrant DNA methylation of the genome
-
additional information
-
inhibitor screening by molecular docking and molecular dynamics simulations
-
additional information
-
no inhibition of Dnmt3b by NSC 56071, NSC 348926, NSC 106084, NSC 622444, NSC 408488, NSC 137546, NSC 345763, NSC 54162, NSC 154957, NSC 158324, NSC 57893, and NSC 138419
-
additional information
not inhibited by 0.045 mM 2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methoxy-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
-
additional information
not inhibited by 0.045 mM 2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methoxy-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
-
additional information
-
not inhibited by 0.045 mM 2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methoxy-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
-
additional information
-
virtual inhibitor screeening, molecular modeling with Dnmt1, overview. No inhibition of Dnmt1 by NSC 345763, NSC 154957, and NSC 158324
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
RNAse A
RNase A treatment increases DNMT1 activity in vitro. The methyltransferase activity on hemimethylated DNA is about 8fold higher compared to control, and 2fold higher on a poly(dI-dC) substrate
-
methylated DNA
-
stimulated methylation spreading on unmethylated CpG sequences for full-length and the mutant lacking 121 N-terminal amino acids equally well. No stimulation of N-terminal deletion mutants lacking 501, 540, or 580 amino acids from the N-terminus
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Aberrant Crypt Foci
Dietary arsenic affects dimethylhydrazine-induced aberrant crypt formation and hepatic global DNA methylation and DNA methyltransferase activity in rats.
Aberrant Crypt Foci
Potent antitumor activity of Laccaic acid and Phenethyl isothiocyanate combination in colorectal cancer via dual inhibition of DNA methyltransferase-1 and Histone deacetylase-1.
Abortion, Spontaneous
A Single Nucleotide Polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion.
Abortion, Spontaneous
Association of DNMT3B and DNMN3L Gene Polymorphisms with Early Pregnancy Loss.
Abortion, Spontaneous
DNA methyltransferase 3A promoter polymorphism is associated with the risk of human spontaneous abortion after assisted reproduction techniques and natural conception.
Abortion, Spontaneous
[Correlation of genomic DNA methylation level with unexplained early spontaneous abortion].
Acne Vulgaris
Milk disrupts p53 and DNMT1, the guardians of the genome: implications for acne vulgaris and prostate cancer.
Acute Coronary Syndrome
Age-dependent decreases in DNA methyltransferase levels and low transmethylation micronutrient levels synergize to promote overexpression of genes implicated in autoimmunity and acute coronary syndromes.
Acute Lung Injury
Transforming Growth Factor-?1 Promotes M1 Alveolar Macrophage Polarization in Acute Lung Injury by Up-Regulating DNMT1 to Mediate the microRNA-124/PELI1/IRF5 Axis.
Adenocarcinoma
A pilot clinical trial of the cytidine deaminase inhibitor tetrahydrouridine combined with decitabine to target DNMT1 in advanced, chemorefractory pancreatic cancer.
Adenocarcinoma
A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor.
Adenocarcinoma
Aberrant DNA methyltransferase expression in pancreatic ductal adenocarcinoma development and progression.
Adenocarcinoma
Association of increased DNA methyltransferase expression with carcinogenesis and poor prognosis in pancreatic ductal adenocarcinoma.
Adenocarcinoma
Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma.
Adenocarcinoma
CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.
Adenocarcinoma
Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells.
Adenocarcinoma
Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer.
Adenocarcinoma
DNA methyltransferase 3a modulates chemosensitivity to gemcitabine and oxaliplatin via CHK1 and AKT in p53?deficient pancreatic cancer cells.
Adenocarcinoma
DNMT3A overexpression is associated with aggressive behavior and enteroblastic differentiation of gastric adenocarcinoma.
Adenocarcinoma
DNMT3a promotes proliferation by activating the STAT3 signaling pathway and depressing apoptosis in pancreatic cancer.
Adenocarcinoma
DNMT3b 39179GT polymorphism and the risk of adenocarcinoma of the colon in Koreans.
Adenocarcinoma
Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition.
Adenocarcinoma
Epigenetic up-regulation of CXCR4 and CXCL12 expression by 17 beta-estradiol and tamoxifen is associated with formation of DNA methyltransferase 3B4 splice variant in Ishikawa endometrial adenocarcinoma cells.
Adenocarcinoma
Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines.
Adenocarcinoma
Estrogen regulates DNA methyltransferase 3B expression in Ishikawa endometrial adenocarcinoma cells.
Adenocarcinoma
HOTAIR Induces Methylation of PCDH10, a Tumor Suppressor Gene, by Regulating DNMT1 and Sponging with miR-148b in Gastric Adenocarcinoma.
Adenocarcinoma
Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas.
Adenocarcinoma
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Adenocarcinoma
Regulation of Human RNA Polymerase III Transcription by DNMT1 and DNMT3a DNA Methyltransferases.
Adenocarcinoma
Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells.
Adenocarcinoma
Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells.
Adenocarcinoma
Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer.
Adenocarcinoma
Single nucleotide polymorphism in DNA methyltransferase 3B promoter and its association with gastric cardiac adenocarcinoma in North China.
Adenocarcinoma
Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model.
Adenocarcinoma
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
Adenocarcinoma of Lung
Deoxyribonucleic acid (DNA) methyltransferase contributes to p16 promoter CpG island methylation in lung adenocarcinoma with smoking.
Adenocarcinoma of Lung
DNMT3a expression pattern and its prognostic value in lung adenocarcinoma.
Adenocarcinoma of Lung
Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression.
Adenocarcinoma of Lung
Long Non-coding RNA LINC00628 Interacts Epigenetically with the LAMA3 Promoter and Contributes to Lung Adenocarcinoma.
Adenocarcinoma of Lung
Low expression of PRKCDBP promoted cisplatin resistance in lung adenocarcinoma by DNMT1 and TNF??.
Adenocarcinoma of Lung
Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer.
Adenocarcinoma of Lung
STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and S-Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma.
Adenocarcinoma, Bronchiolo-Alveolar
Promoter methylation of glutathione S-transferase pi1 and multidrug resistance gene 1 in bronchioloalveolar carcinoma and its correlation with DNA methyltransferase 1 expression.
Adenoma
All Things in Moderation: Prevention of Intestinal Adenomas by DNA Hypomethylation.
Adenoma
Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice.
Adenoma
DNA hypomethylation contributes to genomic instability and intestinal cancer initiation.
Adenoma
DNA methyltransferase and alcohol dehydrogenase: gene-nutrient interactions in relation to risk of colorectal polyps.
Adenoma
Genetic and epigenetic variation in the DNMT3B and MTHFR genes and colorectal adenoma risk.
Adenoma
Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.
Adenoma
Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a.
Adenoma
Quantification of gene-specific methylation of DNMT3B and MTHFR using sequenom EpiTYPER®.
Adenoma
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients.
Adenoma
Tubular adenomas with minor villous changes show molecular features characteristic of tubulovillous adenomas.
Adenomatous Polyposis Coli
Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells.
Adenomatous Polyposis Coli
DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value.
Adenomatous Polyposis Coli
Down-regulation of DNMT3b in PC3 cells effects locus-specific DNA methylation, and represses cellular growth and migration.
Adenomatous Polyposis Coli
Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma.
Adenomatous Polyposis Coli
piRNA-823 Is Involved in Cancer Stem Cell Regulation Through Altering DNA Methylation in Association With Luminal Breast Cancer.
Adenomatous Polyposis Coli
The loss-of-function of DNA methyltransferase 1 by siRNA impairs the growth of non-small cell lung cancer with alleviated side effects via reactivation of RASSF1A and APC in vitro and vivo.
Adenomatous Polyps
Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis.
Adenomatous Polyps
Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma.
Adenomatous Polyps
DNMT3B Expression Might Contribute to Abnormal Methylation of RASSF1A in Lager Colorectal Adenomatous Polyps.
Adenomatous Polyps
Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression.
Adenomyosis
Aberrant Immunoreactivity of Deoxyribonucleic Acid Methyltransferases in Adenomyosis.
Adenomyosis
Downregulation of DNA methyltransferase 3 alpha promotes cell proliferation and invasion of ectopic endometrial stromal cells in adenomyosis.
Alopecia
Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1.
Alzheimer Disease
Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer's disease.
Alzheimer Disease
Association study between the DNMT3A -448A>G polymorphism and risk of Alzheimer's disease in Caucasians of Italian origin.
Alzheimer Disease
Chronic hypoxia facilitates Alzheimer's disease through demethylation of ?-secretase by downregulating DNA methyltransferase 3b.
Alzheimer Disease
DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models.
Alzheimer Disease
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
Alzheimer Disease
DNMT3A rs1550117 Polymorphism is Associated With Late-Onset Alzheimer's Disease in a Chinese Population.
Alzheimer Disease
DNMT3B promoter polymorphisms and risk of late onset Alzheimer's disease.
Alzheimer Disease
Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health.
Alzheimer Disease
Methylation analysis of multiple genes in blood DNA of Alzheimer's disease and healthy individuals.
Alzheimer Disease
Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology.
Alzheimer Disease
The synergistic risk effect of apolipoprotein ?4 and DNA (cytosine-5-)-methyltransferase 3 beta (DNMT3B) haplotype for Alzheimer's disease.
Amnesia
Long-term memory consolidation or reconsolidation impairment induces amnesia with key characteristics that are similar to key learning characteristics.
Amnesia
Peculiarities of Participation of DNA Methyltransferases in the Mechanisms of Storage, Impairment, and Recovery of Conditioned Food Aversion Memory.
Amnesia
Processes of DNA methylation are involved in the mechanisms of amnesia induction and conditioned food aversion memory reconsolidation.
Amnesia
The role of DNA methylation in the mechanisms of memory reconsolidation and development of amnesia.
Amyotrophic Lateral Sclerosis
Epigenetic regulation of motor neuron cell death through DNA methylation.
Amyotrophic Lateral Sclerosis
Functional Restoration of Amyotrophic Lateral Sclerosis Patient-Derived Mesenchymal Stromal Cells Through Inhibition of DNA Methyltransferase.
Amyotrophic Lateral Sclerosis
Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS.
Amyotrophic Lateral Sclerosis
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Anemia
The extracellular signal-regulated kinase 1/2 modulates the intracellular localization of DNA methyltransferase 3A to regulate erythrocytic differentiation.
Anemia, Refractory
Clinical activity and safety of the dual pathway inhibitor rigosertib for higher risk myelodysplastic syndromes following DNA methyltransferase inhibitor therapy.
Anemia, Refractory
Clinical effectiveness of DNA methyltransferase inhibitors and lenalidomide in older patients with refractory anemia with ring sideroblasts: a population-based study in the United States.
Anemia, Refractory
Negative impact on clinical outcome of the mutational co-occurrence of SF3B1 and DNMT3A in refractory anemia with ring sideroblasts (RARS).
Anemia, Sickle Cell
5-Aza-4'-thio-2'-deoxycytidine, a new orally bioavailable non-toxic "best-in-class" DNMT1 depleting agent in clinical development.
Aneurysm
Methylation map genes can be critical in determining the methylome of intracranial aneurysm patients.
Aneurysm
NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment.
Aortic Coarctation
DNMT3A controls miR-200b in cardiac fibroblast autophagy and cardiac fibrosis.
Aortic Valve Stenosis
Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.
Apraxias
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Arteriosclerosis
NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1.
Arthritis
Amelioration of Autoimmune Arthritis in Mice Treated With the DNA Methyltransferase Inhibitor 5'-Azacytidine.
Arthritis
miR-148b-3p affects the pathogenesis of adjuvant-induced arthritis rats through the direct target DNMT1.
Arthritis, Gouty
Association of DNA methyltransferase polymorphisms with susceptibility to primary gouty arthritis.
Arthritis, Rheumatoid
Amelioration of Autoimmune Arthritis in Mice Treated With the DNA Methyltransferase Inhibitor 5'-Azacytidine.
Arthritis, Rheumatoid
Clinical relevance of clonal hematopoiesis in the oldest-old population.
Arthritis, Rheumatoid
Correlation between miR-126 expression and DNA hypomethylation of CD4+ T cells in rheumatoid arthritis patients.
Arthritis, Rheumatoid
DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT1, MeCP2.
Arthritis, Rheumatoid
Global DNA methylation, DNMT1, and MBD2 in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
The -283C/T polymorphism of the DNMT3B gene influences the progression of joint destruction in rheumatoid arthritis.
Ascorbic Acid Deficiency
Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes.
Asthma
5-Aza-2'-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching.
Asthma
DNA methyltransferase 1(DNMT1) induced the expression of suppressors of cytokine signaling3 (Socs3) in a mouse model of asthma.
Asthma
Expression Level of MiRNA-126 in Serum Exosomes of Allergic Asthma Patients and Lung Tissues of Asthmatic Mice.
Astrocytoma
Expression of DNA methyltransferases 1 and 3B correlates with EZH2 and this 3-marker epigenetic signature predicts outcome in glioblastomas.
Astrocytoma
Promoter hypermethylation-mediated down-regulation of CXCL12 in human astrocytoma.
Ataxia
Cataplexy and ataxia: red flags for the diagnosis of DNA methyltransferase 1 mutation.
Ataxia
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Ataxia Telangiectasia
DNA methyltransferase 1 knockdown activates a replication stress checkpoint.
Atherosclerosis
Aberrant MFN2 transcription facilitates homocysteine-induced VSMCs proliferation via the increased binding of c-Myc to DNMT1 in atherosclerosis.
Atherosclerosis
DNA Methylation and the Potential Role of Methyl-Containing Nutrients in Cardiovascular Diseases.
Atherosclerosis
DNA methyltransferase 1 and Krüppel-like factor 4 axis regulates macrophage inflammation and atherosclerosis.
Atherosclerosis
Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review.
Atherosclerosis
Flow-dependent regulation of genome-wide mRNA and microRNA expression in endothelial cells in vivo.
Atherosclerosis
Folic Acid Supplementation Delays Atherosclerotic Lesion Development by Modulating MCP1 and VEGF DNA Methylation Levels In Vivo and In Vitro.
Atherosclerosis
Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality.
Atherosclerosis
Global DNA methylation not increased in chronic hemodialysis patients: a case-control study.
Atherosclerosis
High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(-/-) mice.
Atherosclerosis
Histone Methyltransferase Enhancer of Zeste Homolog 2-Mediated ABCA1 Promoter DNA Methylation Contributes to the Progression of Atherosclerosis.
Atherosclerosis
Homocysteine accelerates atherosclerosis by inhibiting scavenger receptor class B member1 via DNMT3b/SP1 pathway.
Atherosclerosis
Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.
Atherosclerosis
MicroRNA-377 Inhibits Atherosclerosis by Regulating Triglyceride Metabolism Through the DNA Methyltransferase 1 in Apolipoprotein E-Knockout Mice.
Atherosclerosis
Reciprocal Regulation Between miR-148a/152 and DNA Methyltransferase 1 Is Associated with Hyperhomocysteinemia-Accelerated Atherosclerosis.
Atherosclerosis
Relationship of impairment induced by intracellular S-adenosylhomocysteine accumulation with DNA methylation in human umbilical vein endothelial cells treated with 3-deazaadenosine.
Autoimmune Diseases
Association analyses of DNA methyltransferase-1 (DNMT1) polymorphisms with systemic lupus erythematosus.
Autoimmune Diseases
Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo.
Autoimmune Diseases
Natural antisense RNAs are involved in the regulation of CD45 expression in autoimmune diseases.
Autoimmune Diseases
Ultraviolet B inhibition of DNMT1 activity via AhR activation dependent SIRT1 suppression in CD4+ T cells from systemic lupus erythematosus patients.
Bacteremia
Genetic variation of DNA methyltransferase-3A contributes to protection against persistent MRSA bacteremia in patients.
Bacterial Infections
A colorimetric assay of DNA methyltransferase activity based on peroxidase mimicking of DNA template Ag/Pt bimetallic nanoclusters.
Bacterial Infections
A colorimetric assay of DNA methyltransferase activity based on the keypad lock of duplex DNA modified meso-SiO2@Fe3O4.
Bacterial Infections
A methylation-blocked cascade amplification strategy for label-free colorimetric detection of DNA methyltransferase activity.
Bacterial Infections
DNA methyltransferase detection based on digestion triggering the combination of poly adenine DNA with gold nanoparticles.
Bacterial Infections
Magnetic bead-liposome hybrids enable sensitive and portable detection of DNA methyltransferase activity using personal glucose meter.
Biliary Atresia
MicroRNA-29b/142-5p contribute to the pathogenesis of biliary atresia by regulating the IFN-? gene.
Blast Crisis
Absence of DNMT3A gene mutation in chronic myeloid leukemia patients in blast crisis.
Blast Crisis
Long noncoding RNA MEG3 inhibits proliferation of chronic myeloid leukemia cells by sponging microRNA21.
Blast Crisis
The Long Noncoding RNA MEG3 and its Target miR-147 Regulate JAK/STAT Pathway in Advanced Chronic Myeloid Leukemia.
Bone Marrow Failure Disorders
Graft-versus-host disease after liver transplantation is associated with bone marrow failure, hemophagocytosis, and DNMT3A mutations.
Bone Neoplasms
DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1.2 expression in spinal cord dorsal horn.
Brain Diseases
Trimethylaurintricarboxylic acid inhibits human DNA methyltransferase 1: insights from enzymatic and molecular modeling studies.
Brain Injuries
DNA Methylation Inhibitor Zebularine Confers Stroke Protection in Ischemic Rats.
Brain Injuries
Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons.
Brain Injuries, Traumatic
Traumatic brain injury induces relocalization of DNA-methyltransferase 1.
Brain Ischemia
Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons.
Brain Neoplasms
Distinct gene expression profiles between primary breast cancers and brain metastases from pair-matched samples.
Brain Neoplasms
DNMTs as potential therapeutic targets in high-risk pediatric embryonal brain tumors.
Brain Neoplasms
Expression of DNA methylation-related proteins in metastatic breast cancer.
Brain Neoplasms
Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR.
Brain Neoplasms
Methyllysine Reader Plant Homeodomain (PHD) Finger Protein 20-like 1 (PHF20L1) Antagonizes DNA (Cytosine-5) Methyltransferase 1 (DNMT1) Proteasomal Degradation.
Brain Neoplasms
Repurposing Disulfiram as An Anti-Cancer Agent: Updated Review on Literature and Patents.
Brain Neoplasms
The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells.
Brain Neoplasms
World Cancer Day 2021 - Perspectives in Pediatric and Adult Neuro-Oncology.
Breast Neoplasms
3,3'-Diindolylmethane Enhances Paclitaxel Sensitivity by Suppressing DNMT1-Mediated KLF4 Methylation in Breast Cancer.
Breast Neoplasms
5,6-Dihydro-5'-azacytidine (DHAC) affects estrogen sensitivity in estrogen-refractory human breast carcinoma cell lines.
Breast Neoplasms
5-Aza-2'-deoxycytidine advances EMT of breast cancer cells by demethylating Sipa1 promoter-proximal elements.
Breast Neoplasms
5-aza-2'-Deoxycytidine Enhances the Radiosensitivity of Breast Cancer Cells.
Breast Neoplasms
5-Aza-2'-deoxycytidine induces a greater inflammatory change, at the molecular levels, in normoxic than hypoxic tumor microenvironment.
Breast Neoplasms
5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation.
Breast Neoplasms
5-Aza-2-deoxycytidine and trichostatin A increase COUP-TFII expression in antiestrogen-resistant breast cancer cell lines.
Breast Neoplasms
5-AZA-dC induces epigenetic changes associated with modified glycosylation of secreted glycoproteins and increased EMT and migration in chemo-sensitive cancer cells.
Breast Neoplasms
?EF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells.
Breast Neoplasms
A candidate CpG SNP approach identifies a breast cancer associated ESR1-SNP.
Breast Neoplasms
A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells.
Breast Neoplasms
A Comparative Study on the In Vitro Effects of the DNA Methyltransferase Inhibitor 5-Azacytidine (5-AzaC) in Breast/Mammary Cancer of Different Mammalian Species.
Breast Neoplasms
A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk.
Breast Neoplasms
A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1.
Breast Neoplasms
A novel fluorometric oligonucleotide assay to measure O( 6)-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase.
Breast Neoplasms
A novel MspI PCR-RFLP in the human cytosine 5-methyltransferase gene: lack of relevance for malignant lymphoproliferative disease and breast cancer.
Breast Neoplasms
Altered DNA methyltransferases promoter methylation and mRNA expression are associated with tamoxifen response in breast tumors.
Breast Neoplasms
An Evaluation of DNA Methyltransferase 1 (DNMT1) Single Nucleotide Polymorphisms and Chemotherapy-Associated Cognitive Impairment: A Prospective, Longitudinal Study.
Breast Neoplasms
An integrated genomic analysis of Tudor domain-containing proteins identifies PHD finger protein 20-like 1 (PHF20L1) as a candidate oncogene in breast cancer.
Breast Neoplasms
Array-based DNA methylation profiling for breast cancer subtype discrimination.
Breast Neoplasms
Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China.
Breast Neoplasms
Association of DNMT1 gene polymorphisms in exons with sporadic infiltrating ductal breast carcinoma among chinese han women in the Heilongjiang province.
Breast Neoplasms
Association of physical activity and polymorphisms in FGFR2 and DNA methylation related genes with breast cancer risk.
Breast Neoplasms
Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation.
Breast Neoplasms
Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation.
Breast Neoplasms
circIQCH sponges miR-145 to promote breast cancer progression by upregulating DNMT3A expression.
Breast Neoplasms
CircRNA DNA methyltransferase 1 silence inhibits breast cancer development by regulating micoRNA-485-3p/zinc finger E-box binding homeobox 1 axis.
Breast Neoplasms
CLDN6-mediates SB431542 action through MMPs to regulate the invasion, migration, and EMT of breast cancer cells.
Breast Neoplasms
Clinicopathologic significance of DNA methyltransferase 1, 3a, and 3b overexpression in Tunisian breast cancers.
Breast Neoplasms
Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells.
Breast Neoplasms
Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study.
Breast Neoplasms
Comprehensive analysis of regulation of DNA methyltransferase isoforms in human breast tumors.
Breast Neoplasms
Comprehensive bioinformatics study reveals targets and molecular mechanism of hesperetin in overcoming breast cancer chemoresistance.
Breast Neoplasms
CpG island shore methylation regulates caveolin-1 expression in breast cancer.
Breast Neoplasms
Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy.
Breast Neoplasms
Decreased expression of EZH2 reactivates RASSF2A by reversal of promoter methylation in breast cancer cells.
Breast Neoplasms
Demethylating agent 5-aza-2-deoxycytidine enhances susceptibility of breast cancer cells to anticancer agents.
Breast Neoplasms
Derivative of Stevioside; CPUK02; Restores ESR1 Gene Methylation in MDA-MB 231
Breast Neoplasms
Differential expression of the epigenetic methylation-related protein DNMT1 by breast cancer molecular subtype and stromal histology.
Breast Neoplasms
DNA hypermethylation near the transcription start site of collagen alpha2(I) gene occurs in both cancer cell lines and primary colorectal cancers.
Breast Neoplasms
DNA Methylation Affects the SP1-regulated Transcription of FOXF2 in Breast Cancer Cells.
Breast Neoplasms
DNA methylation and not H3K4 trimethylation dictates the expression status of miR-152 gene which inhibits migration of breast cancer cells via DNMT1/CDH1 loop.
Breast Neoplasms
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis.
Breast Neoplasms
DNA Methyltransferase Gene Polymorphisms for Prediction of Radiation-induced Skin Fibrosis after Treatment of Breast Cancer: a Multifactorial Genetic Approach.
Breast Neoplasms
DNA methyltransferase inhibition increases efficacy of adoptive cellular immunotherapy of murine breast cancer.
Breast Neoplasms
DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer.
Breast Neoplasms
DNA methyltransferase inhibitor CDA-2 synergizes with high-dose thiotepa and paclitaxel in killing breast cancer stem cells.
Breast Neoplasms
DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer.
Breast Neoplasms
DNA methyltransferase inhibitors influence on the DIRAS3 and STAT3 expression and in vitro migration of ovarian and breast cancer cells.
Breast Neoplasms
DNMT1 genetic polymorphisms affect breast cancer risk in the central European Caucasian population.
Breast Neoplasms
DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.
Breast Neoplasms
DNMT3a mediates paclitaxel-induced abnormal expression of LINE-1 by increasing the intragenic methylation.
Breast Neoplasms
DNMT3b 39179GT polymorphism and the risk of adenocarcinoma of the colon in Koreans.
Breast Neoplasms
DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines.
Breast Neoplasms
Down-regulation of CXCL12 mRNA expression by promoter hypermethylation and its association with metastatic progression in human breast carcinomas.
Breast Neoplasms
Down-regulation of CXCR4 expression by tamoxifen is associated with DNA methyltransferase 3B up-regulation in MCF-7 breast cancer cells.
Breast Neoplasms
Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis.
Breast Neoplasms
Dysregulation of microRNA expression drives aberrant DNA hypermethylation in basal-like breast cancer.
Breast Neoplasms
Dysregulation of the epigenome in triple-negative breast cancers: Basal-like and claudin-low breast cancers express aberrant DNA hypermethylation.
Breast Neoplasms
E-cadherin, Snail, ZEB-1, DNMT1, DNMT3A and DNMT3B expression in normal and breast cancer tissues.
Breast Neoplasms
Effects of 5-Aza-CdR on the proliferation of human breast cancer cell line MCF-7 and on the expression of Apaf-1 gene.
Breast Neoplasms
Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells.
Breast Neoplasms
Effects of specific DNMT-gene depletion on cancer cell transformation and breast cancer cell invasion; towards selective DNMT inhibitors.
Breast Neoplasms
Endoplasmic reticulum protein 29 (ERp29) confers radioresistance through the DNA repair gene, O(6)-methylguanine DNA-methyltransferase, in breast cancer cells.
Breast Neoplasms
Enhancement of chemotherapeutic efficacy in hypermethylator breast cancer cells through targeted and pharmacologic inhibition of DNMT3b.
Breast Neoplasms
Epigenetic control of phospholipase A2 receptor expression in mammary cancer cells.
Breast Neoplasms
Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours.
Breast Neoplasms
Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer.
Breast Neoplasms
Epigenetic modification in 4T1 mouse breast cancer model by artificial light at night and melatonin - the role of DNA-methyltransferase.
Breast Neoplasms
Epigenetic Modifications, Chromatin Distribution and TP53 Transcription in a Model of Breast Cancer Progression.
Breast Neoplasms
Epigenetic regulation of glycosylation and the impact on chemo-resistance in breast and ovarian cancer.
Breast Neoplasms
Epigenetic Regulation of Manganese Superoxide Dismutase Expression in Human Breast Cancer Cells.
Breast Neoplasms
Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer.
Breast Neoplasms
Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors.
Breast Neoplasms
Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers.
Breast Neoplasms
Epigenetic silencing of genes enhanced by collective role of reactive oxygen species and MAPK signaling downstream ERK/Snail axis: Ectopic application of hydrogen peroxide repress CDH1 gene by enhanced DNA methyltransferase activity in human breast cancer.
Breast Neoplasms
Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer.
Breast Neoplasms
ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor.
Breast Neoplasms
ER? is required for suppressing OCT4-induced proliferation of breast cancer cells via DNMT1/ISL1/ERK axis.
Breast Neoplasms
ER? positively regulated DNMT1 expression by binding to the gene promoter region in human breast cancer MCF-7 cells.
Breast Neoplasms
ER? propelled aberrant global DNA hypermethylation by activating the DNMT1 gene to enhance anticancer drug resistance in human breast cancer cells.
Breast Neoplasms
Evaluation of three mRNA markers for the detection of lymph node metastases.
Breast Neoplasms
Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas.
Breast Neoplasms
Expression and clinicopathological significance of DNA methyltransferase 1, 3A and 3B in tamoxifen-treated breast cancer patients.
Breast Neoplasms
Expression of DNA methyl-transferase (DMT) and the cell cycle in human breast cancer cells.
Breast Neoplasms
FEN1 mediates miR-200a methylation and promotes breast cancer cell growth via MET and EGFR signaling.
Breast Neoplasms
Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer.
Breast Neoplasms
Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.
Breast Neoplasms
Human breast cancer progression can be regulated by dominant trans-acting factors in somatic cell hybridization studies.
Breast Neoplasms
Hypoxia Alters the Response to Anti-EGFR Therapy by Regulating EGFR Expression and Downstream Signaling in a DNA Methylation-Specific and HIF-Dependent Manner.
Breast Neoplasms
Identification of DNA Methyltransferase-1 Inhibitor for Breast Cancer Therapy through Computational Fragment-Based Drug Design.
Breast Neoplasms
Impact of miRNAs expression modulation on the methylation status of breast cancer stem cell-related genes.
Breast Neoplasms
Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer.
Breast Neoplasms
Individual factors define the overall effects of dietary genistein exposure on breast cancer patients.
Breast Neoplasms
Induction of DNMT3B by PGE2 and IL6 at Distant Metastatic Sites Promotes Epigenetic Modification and Breast Cancer Colonization.
Breast Neoplasms
Induction of HRR genes and inhibition of DNMT1 is associated with anthracycline anti-tumor antibiotic-tolerant breast carcinoma cells.
Breast Neoplasms
Induction of the estrogen receptor by ablation of DNMT1 in ER-negative breast cancer cells.
Breast Neoplasms
Induction of transforming growth factor-beta receptor type II expression in estrogen receptor-positive breast cancer cells through SP1 activation by 5-aza-2'-deoxycytidine.
Breast Neoplasms
Inhibition of DNMT1 and ERR? crosstalk suppresses breast cancer via derepression of IRF4.
Breast Neoplasms
Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cells.
Breast Neoplasms
Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells.
Breast Neoplasms
Insulin-like growth factor binding protein-3 (IGFBP-3) plays a role in the anti-tumorigenic effects of 5-Aza-2'-deoxycytidine (AZA) in breast cancer cells.
Breast Neoplasms
Interaction of 5-aza-2'-deoxycytidine and depsipeptide on antineoplastic activity and activation of 14-3-3sigma, E-cadherin and tissue inhibitor of metalloproteinase 3 expression in human breast carcinoma cells.
Breast Neoplasms
Interleukin-6-mediated epigenetic control of the VEGFR2 gene induces disorganized angiogenesis in human breast tumors.
Breast Neoplasms
Joint effects between urinary selenium and polymorphisms in methylation related genes on breast cancer risk.
Breast Neoplasms
Kindlin-2 interacts with and stabilizes DNMT1 to promote breast cancer development.
Breast Neoplasms
KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.
Breast Neoplasms
Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer.
Breast Neoplasms
Laminin-1 induces E-cadherin expression in 3-dimensional cultured breast cancer cells by inhibiting DNA methyltransferase 1 and reversing promoter methylation status.
Breast Neoplasms
LncRNA TINCR favors tumorigenesis via STAT3-TINCR-EGFR-feedback loop by recruiting DNMT1 and acting as a competing endogenous RNA in human breast cancer.
Breast Neoplasms
Long non-coding RNA H19 promotes the proliferation and invasion of breast cancer through upregulating DNMT1 expression by sponging miR-152.
Breast Neoplasms
Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy.
Breast Neoplasms
Loss of DNA Methylation and Histone H4 Lysine 20 Trimethylation in Human Breast Cancer Cells is Associated with Aberrant Expression of DNA Methyltransferase 1, Suv4-20h2 Histone Methyltransferase and Methyl-Binding Proteins.
Breast Neoplasms
Loss of post-transcriptional regulation of DNMT3b by microRNAs: a possible molecular mechanism for the hypermethylation defect observed in a subset of breast cancer cell lines.
Breast Neoplasms
MALAT1 Promotes Tumorigenesis and Increases Cellular Sensitivity to Herceptin in HER2-positive Breast Cancer.
Breast Neoplasms
Metastasis-associated protein 1 is an upstream regulator of DNMT3a and stimulator of insulin-growth factor binding protein-3 in breast cancer.
Breast Neoplasms
Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells.
Breast Neoplasms
Methylation and inhibition of expression of uPA by the RAS oncogene: divergence of growth control and invasion in breast cancer cells.
Breast Neoplasms
Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissue.
Breast Neoplasms
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Breast Neoplasms
MicroRNA-143 is downregulated in breast cancer and regulates DNA methyltransferases 3A in breast cancer cells.
Breast Neoplasms
miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway.
Breast Neoplasms
Mutant p53 binds to estrogen receptor negative promoter via DNMT1 and HDAC1 in MDA-MB-468 breast cancer cells.
Breast Neoplasms
MYC and DNMT3A-mediated DNA methylation represses microRNA-200b in triple negative breast cancer.
Breast Neoplasms
New insights into estrogenic regulation of O(6)-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-? and MGMT proteins by fulvestrant or O(6)-benzylguanine indicates fresh avenues for therapy.
Breast Neoplasms
O-6-methylguanine DNA methyltransferase is a favorable biomarker with proliferation suppressive potential in Breast Cancer.
Breast Neoplasms
Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer.
Breast Neoplasms
Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase ? and a de novo DNA Methyltransferase.
Breast Neoplasms
p53 inhibits the expression of p125 and the methylation of POLD1 gene promoter by downregulating the Sp1-induced DNMT1 activities in breast cancer.
Breast Neoplasms
Physcion 8-O-?-glucopyranoside suppresses the metastasis of breast cancer in vitro and in vivo by modulating DNMT1.
Breast Neoplasms
piRNA-823 Is Involved in Cancer Stem Cell Regulation Through Altering DNA Methylation in Association With Luminal Breast Cancer.
Breast Neoplasms
Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer.
Breast Neoplasms
Pterostilbene leads to DNMT3B-mediated DNA methylation and silencing of OCT1-targeted oncogenes in breast cancer cells.
Breast Neoplasms
QbD Enabled Azacitidine Loaded Liposomal Nanoformulation and Its In Vitro Evaluation.
Breast Neoplasms
Quantitative evaluation of DNMT3B promoter methylation in breast cancer patients using differential high resolution melting analysis.
Breast Neoplasms
Reactivation of SYK expression by inhibition of DNA methylation suppresses breast cancer cell invasiveness.
Breast Neoplasms
Reactivation of Syk gene by AZA suppresses metastasis but not proliferation of breast cancer cells.
Breast Neoplasms
refMiR 142 5p inhibits cell invasion and migration by targeting DNMT1 in breast cancer.
Breast Neoplasms
Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation.
Breast Neoplasms
Restoration of the methylation status of hypermethylated gene promoters by microRNA-29b in human breast cancer: A novel epigenetic therapeutic approach.
Breast Neoplasms
Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex.
Breast Neoplasms
Retraction Note to: Physcion 8-O-?-glucopyranoside suppresses the metastasis of breast cancer in vitro and in vivo by modulating DNMT1.
Breast Neoplasms
Ribavirin restores ESR1 gene expression and tamoxifen sensitivity in ESR1 negative breast cancer cell lines.
Breast Neoplasms
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells.
Breast Neoplasms
RNA interference-mediated knockdown of DNMT1 and DNMT3B induces CXCL12 expression in MCF-7 breast cancer and AsPC1 pancreatic carcinoma cell lines.
Breast Neoplasms
Role of gene promoter methylation regulated by TETs and DNMTs in the overexpression of HLA-G in MCF-7 cells.
Breast Neoplasms
Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells.
Breast Neoplasms
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
Breast Neoplasms
SMAD2 Inactivation Inhibits CLDN6 Methylation to Suppress Migration and Invasion of Breast Cancer Cells.
Breast Neoplasms
Specific inhibition of DNMT1 by antisense oligonucleotides induces re-expression of estrogen receptor-alpha (ER) in ER-negative human breast cancer cell lines.
Breast Neoplasms
Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer.
Breast Neoplasms
Stilbenoid-Mediated Epigenetic Activation of Semaphorin 3A in Breast Cancer Cells Involves Changes in Dynamic Interactions of DNA with DNMT3A and NF1C Transcription Factor.
Breast Neoplasms
Study of the Role of siRNA Mediated Promoter Methylation in DNMT3B Knockdown and Alteration of Promoter Methylation of CDH1, GSTP1 Genes in MDA-MB -453 Cell Line.
Breast Neoplasms
Sulforaphane Alone and in Combination with Clofarabine Epigenetically Regulates the Expression of DNA Methylation-Silenced Tumour Suppressor Genes in Human Breast Cancer Cells.
Breast Neoplasms
Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines.
Breast Neoplasms
Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells.
Breast Neoplasms
Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2'-deoxycytidine-triggered invasiveness.
Breast Neoplasms
The Cancer/Testis Antigen Gene VCX2 Is Rarely Expressed in Malignancies but Can Be Epigenetically Activated Using DNA Methyltransferase and Histone Deacetylase Inhibitors.
Breast Neoplasms
The correlation between DNMT1 and ER? expression and the methylation status of ER?, and its clinical significance in breast cancer.
Breast Neoplasms
The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer.
Breast Neoplasms
The DNMT3B C-->T promoter polymorphism and risk of breast cancer in a British population: a case-control study.
Breast Neoplasms
The effect of folate-related SNPs on clinicopathological features, response to neoadjuvant treatment and survival in pre- and postmenopausal breast cancer patients.
Breast Neoplasms
The low-toxicity 9-cis UAB30 novel retinoid down-regulates the DNA methyltransferases and has anti-telomerase activity in human breast cancer cells.
Breast Neoplasms
The Metallophosphoesterase-Domain-Containing Protein 2 (MPPED2) Gene Acts as Tumor Suppressor in Breast Cancer.
Breast Neoplasms
The possible role of EZH2 and DNMT1 polymorphisms in sporadic triple-negative breast carcinoma in southern Chinese females.
Breast Neoplasms
The Study of DNA Methyltransferase-3B Promoter Variant Genotype among Iranian Sporadic Breast Cancer Patients.
Breast Neoplasms
Therapeutic potential of DNA methyltransferase inhibitors with immune checkpoint inhibitor therapy in breast cancer.
Breast Neoplasms
Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and Breast Cancer Cells: Implications for Therapeutic Targeting.
Breast Neoplasms
Transcriptomics Analysis of the Tumor-Inhibitory Pathways of 6-Thioguanine in MCF-7 Cells via Silencing DNMT1 Activity.
Breast Neoplasms
Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells.
Breast Neoplasms
YY1-mediated long non-coding RNA Kcnq1ot1 promotes the tumor progression by regulating PTEN via DNMT1 in triple negative breast cancer.
Breast Neoplasms
Zebularine Treatment Induces MAGE-A11 Expression and Improves CTL Cytotoxicity Using a Novel Identified HLA-A2-restricted MAGE-A11 Peptide.
Breast Neoplasms
[Apple polyphenol inhibited the proliferation and migration of breast cancer cell MDA-MB-231 mediated by UHRF1].
Breast Neoplasms
[Expression of melanoma-associated antigen-C2 in breast cancers and mechanism].
Breast Neoplasms
[Growth inhibition and demethylation by a component of natural drug, CDP, in cancer cell lines]
Breast Neoplasms
[miR-101 inhibits the proliferation and migration of breast cancer cells via downregulating the expression of DNA methyltransferase 3a].
Breast Neoplasms
[Traditional medicine CDP and promoter demethylation in breast cancer cell lines]
Bronchopulmonary Dysplasia
Of mice and men: correlations between microRNA-17?92 cluster expression and promoter methylation in severe bronchopulmonary dysplasia.
Burkitt Lymphoma
De novo protein synthesis is required for lytic cycle reactivation of Epstein-Barr virus, but not Kaposi's sarcoma-associated herpesvirus, in response to histone deacetylase inhibitors and protein kinase C agonists.
Burkitt Lymphoma
Deregulation of DNMT1, DNMT3B and miR29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis.
Burkitt Lymphoma
DNA methylation enzymes and PRC1 restrict B-cell Epstein-Barr virus oncoprotein expression.
Burkitt Lymphoma
DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma.
Burkitt Lymphoma
Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial.
Carcinogenesis
'Plug and play' microelectrode assisted with Y-motif-mediated primer-free cyclic signal amplification for sensitive quantitation of DNA methyltransferase activity.
Carcinogenesis
3,6-Dihydroxyflavone Suppresses Breast Carcinogenesis by Epigenetically Regulating miR-34a and miR-21.
Carcinogenesis
A concern regarding the current confusion with the human homolog of mouse Np95, ICBP90/UHRF1.
Carcinogenesis
A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.
Carcinogenesis
A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats.
Carcinogenesis
A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma.
Carcinogenesis
A novel DNMT3B subfamily, DeltaDNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer.
Carcinogenesis
A Novel Functional TagSNP Rs7560488 in the DNMT3A1 Promoter Is Associated with Susceptibility to Gastric Cancer by Modulating Promoter Activity.
Carcinogenesis
A regulatory circuit composed of DNA methyltransferases and receptor tyrosine kinases controls lung cancer cell aggressiveness.
Carcinogenesis
Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a.
Carcinogenesis
Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis.
Carcinogenesis
Absence of DICER1, CTCF, RPL22, DNMT3A, TRRAP, IDH1 and IDH2 hotspot mutations in patients with various subtypes of ovarian carcinomas.
Carcinogenesis
An association between overexpression of DNA methyltransferase 3B4 and clear cell renal cell carcinoma.
Carcinogenesis
An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection.
Carcinogenesis
Angiogenin contributes to bladder cancer tumorigenesis by DNMT3b-mediated MMP2 activation.
Carcinogenesis
Association between DNA Methyltransferases 3B Gene Polymorphisms and the Susceptibility to Acute Myeloid Leukemia in Chinese Han Population.
Carcinogenesis
Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan.
Carcinogenesis
Association of increased DNA methyltransferase expression with carcinogenesis and poor prognosis in pancreatic ductal adenocarcinoma.
Carcinogenesis
Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis.
Carcinogenesis
Changes in de novo DNA (cytosine-5-)-methyltransferase activity in oncogenically susceptible rat target tissues induced by N-methyl-N-nitrosourea.
Carcinogenesis
Class I HDACs Are Mediators of Smoke Carcinogen-Induced Stabilization of DNMT1 and Serve as Promising Targets for Chemoprevention of Lung Cancer.
Carcinogenesis
Cloning, expression and chromosome locations of the human DNMT3 gene family.
Carcinogenesis
Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice.
Carcinogenesis
De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands.
Carcinogenesis
De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase.
Carcinogenesis
Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis.
Carcinogenesis
Delta DNMT3B variants regulate DNA methylation in a promoter-specific manner.
Carcinogenesis
Deoxyribonucleic acid (DNA) methyltransferase contributes to p16 promoter CpG island methylation in lung adenocarcinoma with smoking.
Carcinogenesis
Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell.
Carcinogenesis
DNA Electrochemistry Shows DNMT1 Methyltransferase Hyperactivity in Colorectal Tumors.
Carcinogenesis
DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis.
Carcinogenesis
DNA hypomethylation contributes to genomic instability and intestinal cancer initiation.
Carcinogenesis
DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas.
Carcinogenesis
DNA methyltransferase 1 expression and promoter methylation of E-cadherin in mucoepidermoid carcinoma.
Carcinogenesis
DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation.
Carcinogenesis
DNA Methyltransferase 1: A Potential Gene Therapy Target for Hepatocellular Carcinoma?
Carcinogenesis
DNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18INK4C in gastric carcinogenesis.
Carcinogenesis
DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma.
Carcinogenesis
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair.
Carcinogenesis
DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers.
Carcinogenesis
DNA methyltransferase inhibition reduces inflammation-induced colon tumorigenesis.
Carcinogenesis
DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors.
Carcinogenesis
DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model.
Carcinogenesis
DNA-based hybridization chain reaction amplification for assaying the effect of environmental phenolic hormone on DNA methyltransferase activity.
Carcinogenesis
DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells.
Carcinogenesis
DNMT1 and DNMT3B regulate tumorigenicity of human prostate cancer cells by controlling RAD9 expression through targeted methylation.
Carcinogenesis
DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.
Carcinogenesis
DNMT1 overexpression predicting gastric carcinogenesis, subsequent progression and prognosis: a meta and bioinformatic analysis.
Carcinogenesis
DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis.
Carcinogenesis
Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele.
Carcinogenesis
Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis.
Carcinogenesis
DNMT3a epigenetic program regulates the HIF-2? oxygen-sensing pathway and the cellular response to hypoxia.
Carcinogenesis
DNMT3a promotes proliferation by activating the STAT3 signaling pathway and depressing apoptosis in pancreatic cancer.
Carcinogenesis
DNMT3A rs36012910 A>G polymorphism and gastric cancer susceptibility in a Chinese population.
Carcinogenesis
DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.
Carcinogenesis
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.
Carcinogenesis
DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells.
Carcinogenesis
DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation.
Carcinogenesis
DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer.
Carcinogenesis
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing.
Carcinogenesis
DNMT3B silencing suppresses migration and invasion by epigenetically promoting miR-34a in bladder cancer.
Carcinogenesis
Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite.
Carcinogenesis
Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis.
Carcinogenesis
Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer.
Carcinogenesis
EBV as a high infection risk factor promotes RASSF10 methylation and induces cell proliferation in EBV-associated gastric cancer.
Carcinogenesis
Effect of a single treatment with the alkylating carcinogens dimethylnitrosamine and methyl methanesulphonate on liver regenerating after partial hepatectomy. IV. Effect on methylase-mediated methylation of DNA.
Carcinogenesis
Effects on biological behavior of bladder carcinoma T24 cells via silencing DNMT1 and/or DNMT3b with shRNA In Vitro.
Carcinogenesis
Epidrug Modulated Expression of MiR--152 and MiR-148a Reverse Cisplatin Resistance in Ovarian Cancer Cells: An Experimental In-vitro Study.
Carcinogenesis
Epigenetic Modifications, Chromatin Distribution and TP53 Transcription in a Model of Breast Cancer Progression.
Carcinogenesis
Epigenetic regulation of p62/SQSTM1 overcomes the radioresistance of head and neck cancer cells via autophagy-dependent senescence induction.
Carcinogenesis
Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition.
Carcinogenesis
Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma.
Carcinogenesis
Epigenetically deregulated miR-200c is involved in a negative feedback loop with DNMT3a in gastric cancer cells.
Carcinogenesis
Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.
Carcinogenesis
Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis.
Carcinogenesis
Expression of DNA (5-cytosin)-methyltransferases (DNMTs) in hepatocellular carcinomas.
Carcinogenesis
Expression of prokaryotic HhaI DNA methyltransferase is transforming and lethal to NIH 3T3 cells.
Carcinogenesis
Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma.
Carcinogenesis
Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization.
Carcinogenesis
Gene expression and promoter polymorphisms of DNA methyltransferase 3B in nasopharyngeal carcinomas in Taiwanese people: a case-control study.
Carcinogenesis
GLAD-PCR Assay of R(5mC)GY Sites in the Regulatory Region of Tumor-Suppressor Genes Associated with Gastric Cancer.
Carcinogenesis
HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence.
Carcinogenesis
Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis.
Carcinogenesis
Hepatitis B virus infection in hepatocellular carcinoma tissues upregulates expression of DNA methyltransferases.
Carcinogenesis
hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing.
Carcinogenesis
Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway.
Carcinogenesis
Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.
Carcinogenesis
Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.
Carcinogenesis
Hypomethylation of LIMD1 and P16 by downregulation of DNMT1 results in restriction of liver carcinogenesis by amarogentin treatment.
Carcinogenesis
Identification of potential genes regulated by DNA methyltransferase 3B in a hepatocellular carcinoma cell line by RNA interference and microarray analysis.
Carcinogenesis
Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.
Carcinogenesis
Increased DNA methyltransferase 1 (DNMT1) gene expression in human lymphomas by fluorescent in situ hybridization.
Carcinogenesis
Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers.
Carcinogenesis
Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas.
Carcinogenesis
Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder.
Carcinogenesis
Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion.
Carcinogenesis
Increased expression of DNA methyltransferase-1 in non-neoplastic epithelium helps predict colorectal neoplasia risk in ulcerative colitis.
Carcinogenesis
Inhibition of DNA methyltransferase 1 by RNA interference reverses epithelial-mesenchymal transition in highly metastatic 95D lung cancer cells by inhibiting the Wnt signaling pathway.
Carcinogenesis
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Carcinogenesis
Inhibition of DNA methyltransferase by antisense oligodeoxynucleotide modifies cell characteristics in gastric cancer cell lines.
Carcinogenesis
Inhibition of DNMT suppresses the stemness of colorectal cancer cells through down-regulating Wnt signaling pathway.
Carcinogenesis
Interplay between DNA Methyltransferase 1 and microRNAs During Tumorigenesis.
Carcinogenesis
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Carcinogenesis
Kaposi's Sarcoma-Associated Herpesvirus (KSHV) vIL-6 Promotes Cell Proliferation and Migration by Upregulating DNMT1 via STAT3 Activation.
Carcinogenesis
LINC00337 promotes tumor angiogenesis in colorectal cancer by recruiting DNMT1, which suppresses the expression of CNN1.
Carcinogenesis
LncRNA TINCR favors tumorigenesis via STAT3-TINCR-EGFR-feedback loop by recruiting DNMT1 and acting as a competing endogenous RNA in human breast cancer.
Carcinogenesis
Long non-coding RNA BZRAP1-AS1 silencing suppresses tumor angiogenesis in hepatocellular carcinoma by mediating THBS1 methylation.
Carcinogenesis
Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-?.
Carcinogenesis
Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis.
Carcinogenesis
Mandatory fortification with folic acid in the United States is associated with increased expression of DNA methyltransferase-1 in the cervix.
Carcinogenesis
Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.
Carcinogenesis
Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.
Carcinogenesis
Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.
Carcinogenesis
MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in hepatocellular carcinogenesis.
Carcinogenesis
MiR-137 Suppresses Triple-Negative Breast Cancer Stemness and Tumorigenesis by Perturbing BCL11A-DNMT1 Interaction.
Carcinogenesis
MiR-143 inhibits cell proliferation and invasion by targeting DNMT3A in gastric cancer.
Carcinogenesis
MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1.
Carcinogenesis
miR-182 induces cervical cancer cell apoptosis through inhibiting the expression of DNMT3a.
Carcinogenesis
Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants.
Carcinogenesis
Multiple sealed primers-mediated rolling circle amplification strategy for sensitive and specific detection of DNA methyltransferase activity.
Carcinogenesis
Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers.
Carcinogenesis
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Carcinogenesis
Mutations in DNA Methyltransferase (DNMT3A) Observed in Acute Myeloid Leukemia Patients Disrupt Processive Methylation.
Carcinogenesis
New insights into testicular germ cell tumorigenesis from gene expression profiling.
Carcinogenesis
NNK-induced DNA methyltransferase 1 in lung tumorigenesis in A/J mice and inhibitory effects of (-)-epigallocatechin-3-gallate.
Carcinogenesis
NOP2/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL6 in gallbladder carcinoma.
Carcinogenesis
NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization.
Carcinogenesis
Overexpression of DNA methyltransferase 1 (DNMT1) protein in astrocytic tumour and its correlation with O6-methylguanine-DNA methyltransferase (MGMT) expression.
Carcinogenesis
Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma.
Carcinogenesis
Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome.
Carcinogenesis
Phase 1 Study of Preoperative Chemoradiation Therapy With Temozolomide and Capecitabine in Patients With Locally Advanced Rectal Cancer.
Carcinogenesis
Polymorphism of DNA Methyltransferase 3b and Association with Development and Prognosis in Gastric Cancer.
Carcinogenesis
PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A.
Carcinogenesis
Quantitative assessment of the association between DNMT3B-579G>T polymorphism and cancer risk.
Carcinogenesis
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Carcinogenesis
Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice.
Carcinogenesis
Reduction of two histone marks, H3k9me3 and H3k27me3 by epidrug induces neuroendocrine differentiation in prostate cancer.
Carcinogenesis
Regulatory loop between lncRNA FAS-AS1 and DNMT3b controls FAS expression in hydroquinone-treated TK6 cells and benzene-exposed workers.
Carcinogenesis
Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis.
Carcinogenesis
Restoration of miR-101 suppresses lung tumorigenesis through inhibition of DNMT3a-dependent DNA methylation.
Carcinogenesis
RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation.
Carcinogenesis
Risk-association of DNA methyltransferases polymorphisms with gastric cancer in the southern chinese population.
Carcinogenesis
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells.
Carcinogenesis
RNF43 mutations are recurrent in Chinese patients with mucinous ovarian carcinoma but absent in other subtypes of ovarian cancer.
Carcinogenesis
Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer.
Carcinogenesis
Single nucleotide polymorphism in DNMT3B promoter and its association with hepatocellular carcinoma in a Moroccan population.
Carcinogenesis
Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties.
Carcinogenesis
Somatic Mutation Profiling of Papillary Thyroid Carcinomas by Whole-exome Sequencing and Its Relationship with Clinical Characteristics.
Carcinogenesis
Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer.
Carcinogenesis
Suppressing effects of down-regulating DNMT1 and DNMT3b expression on the growth of human cholangiocarcinoma cell line.
Carcinogenesis
The DNMT1/miR-34a Axis Is Involved in the Stemness of Human Osteosarcoma Cells and Derived Stem-Like Cells.
Carcinogenesis
The expressions of DNA methyltransferase 1 (DNMT1) and cyclin A1 (CCNA1) in cervical carcinogenesis.
Carcinogenesis
The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy.
Carcinogenesis
The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma.
Carcinogenesis
The loss-of-function of DNA methyltransferase 1 by siRNA impairs the growth of non-small cell lung cancer with alleviated side effects via reactivation of RASSF1A and APC in vitro and vivo.
Carcinogenesis
The Mammalian de novo DNA Methyltransferases Dnmt3a and Dnmt3b Are Also DNA 5-Hydroxymethyl Cytosine Dehydroxymethylases.
Carcinogenesis
The possible role of EZH2 and DNMT1 polymorphisms in sporadic triple-negative breast carcinoma in southern Chinese females.
Carcinogenesis
The R882H substitution in the human de novo DNA methyltransferase DNMT3A disrupts allosteric regulation by the tumor supressor p53.
Carcinogenesis
The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA.
Carcinogenesis
The rs1550117 A>G variant in DNMT3A gene promoter significantly increases non-small cell lung cancer susceptibility in a Han Chinese population.
Carcinogenesis
The tobacco carcinogen NNK drives accumulation of DNMT1 at the GR promoter thereby reducing GR expression in untransformed lung fibroblasts.
Carcinogenesis
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients.
Carcinogenesis
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in Laryngeal carcinoma.
Carcinogenesis
Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2F-Rb-HDAC-dependent and -independent pathways.
Carcinogenesis
Up-regulation of DNA-methyltransferase 3A expression is associated with hypomethylation of intron 25 in human testicular germ cell tumors.
Carcinogenesis
Up-regulation of DNMT3b contributes to HOTAIRM1 silencing via DNA hypermethylation in cells transformed by long-term exposure to hydroquinone and workers exposed to benzene.
Carcinogenesis
Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6.
Carcinogenesis
Utilization of antisense oligonucleotides to study the role of 5-cytosine DNA methyltransferase in cellular transformation and oncogenesis.
Carcinogenesis
[Effects of Dnmt1 and Dnmt3b in mucoepidermoid carcinoma of salivary glands].
Carcinogenesis
[Effects of dnmt1 Gene Silencing on Cell Cycle, Proliferation, and Apoptosis of Gastric Cancer Cell Line AGS.]
Carcinogenesis
[Expression of DNA methyltransferases in salivary adenoid cystic carcinoma and its association with the CpG islands methylation of tumor suppressor genes]
Carcinogenesis
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
Carcinogenesis
[Interaction of folate deficiency and aberrant profile of DNA methyltransferase 1 in the progression of cervix carcinogenesis].
Carcinoma
5,6 Dihydro-5'-azacytidine (DHAC) restores androgen responsiveness in androgen-insensitive prostate cancer cells.
Carcinoma
A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma.
Carcinoma
Aberrant DNA methyltransferase 1 expression in clear cell renal cell carcinoma development and progression.
Carcinoma
Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications.
Carcinoma
Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis.
Carcinoma
Absence of DICER1, CTCF, RPL22, DNMT3A, TRRAP, IDH1 and IDH2 hotspot mutations in patients with various subtypes of ovarian carcinomas.
Carcinoma
Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma.
Carcinoma
Activation of DNA methyltransferase 3a by Epstein-Barr nuclear antigen 1 in gastric carcinoma.
Carcinoma
Activation of PAR4 Upregulates p16 through Inhibition of DNMT1 and HDAC2 Expression via MAPK Signals in Esophageal Squamous Cell Carcinoma Cells.
Carcinoma
An association between overexpression of DNA methyltransferase 3B4 and clear cell renal cell carcinoma.
Carcinoma
Analysis of Association Between MGMT and p53 Gene Single Nucleotide Polymorphisms and Laryngeal Cancer.
Carcinoma
Anti-invasive effects of decitabine, a DNA methyltransferase inhibitor, through tightening of tight junctions and inhibition of matrix metalloproteinase activities in AGS human gastric carcinoma cells.
Carcinoma
Azacitidine, as a DNMT inhibitor decreases hTERT gene expression and telomerase activity more effective compared with HDAC inhibitor in human Head and neck squamous cell carcinoma cell lines.
Carcinoma
Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis.
Carcinoma
Chemotherapy and Radiotherapy Downregulate the Activity and Expression of DNA Methyltransferase and Enhance Bcl-2/E1B-19-kDa Interacting Protein-3-Induced Apoptosis in Human Colorectal Cancer Cells.
Carcinoma
Combined effects of DNA methyltransferase 1 and 3A polymorphisms and urinary total arsenic levels on the risk for clear cell renal cell carcinoma.
Carcinoma
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma.
Carcinoma
Demethylating agent 5-aza-2'-deoxycytidine enhances susceptibility of bladder transitional cell carcinoma to Cisplatin.
Carcinoma
Demethylating agent 5-aza-2'-deoxycytidine enhances susceptibility of renal cell carcinoma to paclitaxel.
Carcinoma
Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer.
Carcinoma
Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells.
Carcinoma
DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis.
Carcinoma
DNA methylation by DNMT1 and DNMT3b methyltransferases is driven by the MUC1-C oncoprotein in human carcinoma cells.
Carcinoma
DNA methylation status of hMLH1, p16(INK4a), and CDH1 is not associated with mRNA expression levels of DNA methyltransferase and DNA demethylase in gastric carcinomas.
Carcinoma
DNA methylation-mediated Klotho silencing is an independent prognostic biomarker of head and neck squamous carcinoma.
Carcinoma
DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer.
Carcinoma
DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation.
Carcinoma
DNA methyltransferase 3B -149C/T polymorphism and the risk of laryngeal squamous cell carcinoma: a case-control study.
Carcinoma
DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis.
Carcinoma
DNA methyltransferase inhibitor-mediated apoptosis in the Wnt/?-catenin signal pathway in a renal cell carcinoma cell line.
Carcinoma
DNA methyltransferase inhibitors influence on the DIRAS3 and STAT3 expression and in vitro migration of ovarian and breast cancer cells.
Carcinoma
DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells.
Carcinoma
DNMT1 Enhances the Radiosensitivity of HPV-Positive Head and Neck Squamous Cell Carcinomas via Downregulating SMG1.
Carcinoma
DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells.
Carcinoma
DNMT3B -579 G>T promoter polymorphism and risk of gallbladder carcinoma in North Indian population.
Carcinoma
E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines.
Carcinoma
Effect of 5-aza-2'-deoxycytidine on Estrogen Receptor Alpha/Beta and DNA Methyltransferase 1 Genes Expression, Apoptosis Induction, and Cell Growth Prevention of the Colon Cancer HT 29 Cell Line.
Carcinoma
Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival.
Carcinoma
Effect of antisense DNMT3b gene eukaryotic expression plasmid on expression of the DNMT3b gene in human biliary tract carcinoma cells.
Carcinoma
Effect of DNA Methyltransferase in Comparison to and
in Combination with Histone Deacetylase Inhibitors on
Hepatocellular Carcinoma HepG2 Cell Line
Carcinoma
Effects of DNA methyltransferase 1 inhibition on esophageal squamous cell carcinoma.
Carcinoma
Effects on biological behavior of bladder carcinoma T24 cells via silencing DNMT1 and/or DNMT3b with shRNA In Vitro.
Carcinoma
Epigenetic regulation of chemosensitivity to 5-fluorouracil and cisplatin by zebularine in oral squamous cell carcinoma.
Carcinoma
Epigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer.
Carcinoma
Epigenetics and prostate cancer: defining the timing of DNA methyltransferase deregulation during prostate cancer progression.
Carcinoma
Expression of DNMTs and genomic DNA methylation in gastric signet ring cell carcinoma.
Carcinoma
Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma.
Carcinoma
Expression profiles and function of IL6 in polymorphonuclear myeloid-derived suppressor cells.
Carcinoma
Expression profiling and clinicopathological significance of DNA methyltransferase 1, 3A and 3B in sporadic human renal cell carcinoma.
Carcinoma
Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization.
Carcinoma
FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.
Carcinoma
Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
Carcinoma
Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.
Carcinoma
High DNMT1 Is Associated With Worse Local Control in Early-Stage Laryngeal Squamous Cell Carcinoma.
Carcinoma
Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.
Carcinoma
Hypermethylation of the progesterone receptor A in constitutive antiprogestin-resistant mouse mammary carcinomas.
Carcinoma
Immunohistochemical analysis of polycomb group protein expression in advanced gastric cancer.
Carcinoma
Immunohistochemical evaluation of Klotho and DNA methyltransferase 3a in oral squamous cell carcinomas.
Carcinoma
Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas.
Carcinoma
Increased CXCR4 expression in AsPC1 pancreatic carcinoma cells with RNA interference-mediated knockdown of DNMT1 and DNMT3B.
Carcinoma
Increased DNA methyltransferase 1 protein expression correlates significantly with intestinal histological type and gender in gastric carcinomas.
Carcinoma
Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder.
Carcinoma
Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion.
Carcinoma
Increased NQO1 but not c-MET and survivin expression in non-small cell lung carcinoma with KRAS mutations.
Carcinoma
Influence of gossypol acetic acid on the growth of human adenoid cystic carcinoma ACC-M cells and the expression of DNA methyltransferase 1.
Carcinoma
Interleukin 6 induces cell proliferation of clear cell renal cell carcinoma by suppressing hepaCAM via the STAT3-dependent up-regulation of DNMT1 or DNMT3b.
Carcinoma
Investigation of the expression patterns and correlation of DNA methyltransferases and class I histone deacetylases in ovarian cancer tissues.
Carcinoma
Long noncoding RNA ATB participates in the development of renal cell carcinoma by downregulating p53 via binding to DNMT1.
Carcinoma
Lower expression of p14ARF and p16INK4a correlates with higher DNMT3B expression in human oesophageal squamous cell carcinomas.
Carcinoma
Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.
Carcinoma
MG98, a second-generation DNMT1 inhibitor, in the treatment of advanced renal cell carcinoma.
Carcinoma
miR-182 induces cervical cancer cell apoptosis through inhibiting the expression of DNMT3a.
Carcinoma
MiR-29a is a candidate biomarker of better survival in metastatic high-grade serous carcinoma.
Carcinoma
Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma.
Carcinoma
Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood.
Carcinoma
Nanodiamond-mediated impairment of nucleolar activity is accompanied by oxidative stress and DNMT2 upregulation in human cervical carcinoma cells.
Carcinoma
Natural Compounds: DNA Methyltransferase Inhibitors in Oral Squamous Cell Carcinoma.
Carcinoma
Non-invasive detection of DNA methylation states in carcinoma and pluripotent stem cells using Raman microspectroscopy and imaging.
Carcinoma
Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma.
Carcinoma
NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization.
Carcinoma
Over-expression of DNA methyltransferases and CDKN2A gene methylation status in squamous cell carcinoma of the oral cavity.
Carcinoma
Over-expression of DNMT3A predicts the risk of recurrent vulvar squamous cell carcinomas.
Carcinoma
Overexpression of maelstrom promotes bladder urothelial carcinoma cell aggressiveness by epigenetically downregulating MTSS1 through DNMT3B.
Carcinoma
p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding.
Carcinoma
Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation.
Carcinoma
Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
Carcinoma
piR-823 demonstrates tumor oncogenic activity in esophageal squamous cell carcinoma through DNA methylation induction via DNA methyltransferase 3B.
Carcinoma
Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study.
Carcinoma
Promoter polymorphisms of DNMT3B and the risk of head and neck squamous cell carcinoma in Taiwan: a case-control study.
Carcinoma
Protein expression, mRNA expression and gene amplification of DNA methyltransferase 1 in endometrial tumor tissues.
Carcinoma
Quantitative Assessment of AKAP12 Promoter Methylation in Human Prostate Cancer Using Methylation-sensitive High-resolution Melting: Correlation With Gleason Score.
Carcinoma
Re-expression of RASSF1A by 5-Aza-CdR induced demethylation of the promoter region in human biliary tract carcinoma cells.
Carcinoma
RNA interference-mediated knockdown of DNMT1 and DNMT3B induces CXCL12 expression in MCF-7 breast cancer and AsPC1 pancreatic carcinoma cell lines.
Carcinoma
RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner.
Carcinoma
RNF43 mutations are recurrent in Chinese patients with mucinous ovarian carcinoma but absent in other subtypes of ovarian cancer.
Carcinoma
Role of Loss of O-Methylguanine DNA Methyltransferase (MGMT) Expression in Non-Small Cell Lung Carcinomas (NSCLCs): with Reference to the Relationship with p53 Overexpression.
Carcinoma
Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression.
Carcinoma
Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer.
Carcinoma
Silencing DNA methyltransferase 1 (DNMT1) inhibits proliferation, metastasis and invasion in ESCC by suppressing methylation of RASSF1A and DAPK.
Carcinoma
Silencing DNA methyltransferase 1 leads to the activation of the esophageal suppressor gene p16 in vitro and in vivo.
Carcinoma
Structure-activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1.
Carcinoma
Suppression of DNA methyltransferase 1 levels in head and neck squamous carcinoma cells using small interfering RNA results in growth inhibition and increase in Cdk inhibitor p21.
Carcinoma
Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma.
Carcinoma
Tamoxifen accelerates proteasomal degradation of O(6)-methylguanine DNA methyltransferase in human cancer cells.
Carcinoma
The clinical significance of methylation of MAGE-A1 and-A3 promoters and expression of DNA methyltransferase in patients with laryngeal squamous cell carcinoma.
Carcinoma
The involvement of promoter methylation and DNA methyltransferase-1 in the regulation of EpCAM expression in oral squamous cell carcinoma.
Carcinoma
The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma.
Carcinoma
The Receptor Tyrosine Kinase RON and Its Isoforms as Therapeutic Targets in Ewing Sarcoma.
Carcinoma
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in Laryngeal carcinoma.
Carcinoma
Transcriptional analysis of CXCR4, DNMT3A, DNMT3B and DNMT1 gene expression in primary advanced uterine cervical carcinoma.
Carcinoma
[Characteristic and clinical significance of DNA methyltransferase 3B overexpression in endometrial carcinoma].
Carcinoma
[Clinicopathologic features and protein expression study of Epstein-Barr virus-associated gastric carcinoma in Guangzhou].
Carcinoma
[Expression of DNA methyltransferase 1, 3A and 3B mRNA in the epithelial ovarian carcinoma]
Carcinoma
[Gene expressions of DNA methyltransferase 1 and human leukocyte antigen-DRalpha in hepatocelluar carcinoma and their clinical significance.]
Carcinoma
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
Carcinoma
[Study on the combined therapy of DNA-methyltransferase inhibitor and interferon-alpha/beta for mouse spontaneously arose renal cell carcinoma, and immunological mechanism induced by the therapy]
Carcinoma
[Synthesized small interfering RNA inhibits the expression of DNA methyltransferase 1 in salivary adenoid cystic carcinoma]
Carcinoma
[The expression of DNMT1 in laryngeal squamous cell carcinoma and its clinical significance].
Carcinoma
[The Study of Methylated Regulation MicroRNA in Pancreatic Carcinoma Cell and Its Effect on Cell Proliferation,Migration and Invasion].
Carcinoma in Situ
Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder.
Carcinoma, Adenoid Cystic
ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma.
Carcinoma, Adenoid Cystic
Immunolocalization of DNMT1 and DNMT3a in salivary gland neoplasms.
Carcinoma, Adenoid Cystic
Influence of gossypol acetic acid on the growth of human adenoid cystic carcinoma ACC-M cells and the expression of DNA methyltransferase 1.
Carcinoma, Adenoid Cystic
[Synthesized small interfering RNA inhibits the expression of DNA methyltransferase 1 in salivary adenoid cystic carcinoma]
Carcinoma, Ductal
DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas.
Carcinoma, Ductal
Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas.
Carcinoma, Ductal
The expression patterns and correlations of claudin-6, methy-CpG binding protein 2, DNA methyltransferase 1, histone deacetylase 1, acetyl-histone H3 and acetyl-histone H4 and their clinicopathological significance in breast invasive ductal carcinomas.
Carcinoma, Embryonal
A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.
Carcinoma, Embryonal
Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives.
Carcinoma, Embryonal
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.
Carcinoma, Embryonal
DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer.
Carcinoma, Embryonal
Genome-wide expression profiling reveals new insights into pathogenesis and progression of testicular germ cell tumors.
Carcinoma, Embryonal
Meta-Analysis of Gene Expressions in Testicular Germ Cell Tumor Histologies.
Carcinoma, Embryonal
Regulation of DNA methyltransferase during differentiation of F9 mouse embryonal carcinoma cells.
Carcinoma, Endometrioid
Down-regulation of miR-145 and miR-143 might be associated with DNA methyltransferase 3B overexpression and worse prognosis in endometrioid carcinomas.
Carcinoma, Endometrioid
Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.
Carcinoma, Endometrioid
Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers.
Carcinoma, Endometrioid
[Characteristic and clinical significance of DNA methyltransferase 3B overexpression in endometrial carcinoma].
Carcinoma, Hepatocellular
Alterations in gene expression associated with the overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, during human hepatocarcinogenesis.
Carcinoma, Hepatocellular
Anticancer drugs induce hypomethylation of the acetylcholinesterase promoter via a phosphorylated-p38-DNMT1-AChE pathway in apoptotic hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Casticin inhibits stemness of hepatocellular carcinoma cells via disrupting the reciprocal negative regulation between DNMT1 and miR-148a-3p.
Carcinoma, Hepatocellular
Chlorogenic Acid Decreases Malignant Characteristics of Hepatocellular Carcinoma Cells by Inhibiting DNMT1 Expression.
Carcinoma, Hepatocellular
Correlative Analysis of DNA Methyltransferase Expression and Promoter Hypermethylation of Tumor Suppressor Genes in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell.
Carcinoma, Hepatocellular
DNA methylase activity of normal liver, regenerating liver, and a transplantable hepatocellular carcinoma.
Carcinoma, Hepatocellular
DNA methylation controls the responsiveness of hepatoma cells to leukemia inhibitory factor.
Carcinoma, Hepatocellular
DNA methyltransferase 1 knockdown induces silenced CDH1 gene reexpression by demethylation of methylated CpG in hepatocellular carcinoma cell line SMMC-7721.
Carcinoma, Hepatocellular
DNA methyltransferase 1, 3a, and 3b expression in hepatitis C associated human hepatocellular carcinoma and their clinicopathological association.
Carcinoma, Hepatocellular
DNA Methyltransferase 1: A Potential Gene Therapy Target for Hepatocellular Carcinoma?
Carcinoma, Hepatocellular
DNA methyltransferase 3B promoter polymorphism and its susceptibility to primary hepatocellular carcinoma in the Chinese Han nationality population: a case-control study.
Carcinoma, Hepatocellular
DNA methyltransferase 3b silencing affects locus-specific DNA methylation and inhibits proliferation, migration and invasion in human hepatocellular carcinoma SMMC-7721 and BEL-7402 cells.
Carcinoma, Hepatocellular
DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation.
Carcinoma, Hepatocellular
DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8.
Carcinoma, Hepatocellular
DNMT1 mediated promoter methylation of GNAO1 in hepatoma carcinoma cells.
Carcinoma, Hepatocellular
DNMT3A -448A>G polymorphism and the risk for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1.
Carcinoma, Hepatocellular
Dual targeting of histone methyltransferase G9a and DNA-methyltransferase 1 for the treatment of experimental hepatocellular carcinoma.
Carcinoma, Hepatocellular
Effect of 5-aza-2'-deoxycytidine on immune-associated proteins in exosomes from hepatoma.
Carcinoma, Hepatocellular
Effect of 5-aza-2'-deoxycytidine on p27Kip1, p21Cip1/Waf1/Sdi1, p57Kip2, and DNA methyltransferase 1 Genes Expression, Cell Growth Inhibition and Apoptosis Induction in Colon Cancer SW 480 and SW 948 Cell Lines.
Carcinoma, Hepatocellular
Effect of Decitabine (5-aza-2'-deoxycytidine, 5-aza-CdR) in Comparison with Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) on DNMT1, DNMT3a and DNMT3b, HDAC 1-3, SOCS 1, SOCS 3, JAK2, and STAT3 Gene Expression in Hepatocellular Carcinoma HLE and LCL-PI 11 Cell Lines.
Carcinoma, Hepatocellular
Effect of Zebularine on p16INK4a, p14ARF, p15INK4b, and DNA Methyltransferase 1 Gene Expression, Cell Growth Inhibition, and Apoptosis Induction in Human Hepatocellular Carcinoma PLC/PRF5 and Pancreatic Cancer PA-TU-8902 Cell Lines.
Carcinoma, Hepatocellular
Epigenetic silencing of NAD(P)H:quinone oxidoreductase 1 by hepatitis B virus X protein increases mitochondrial injury and cellular susceptibility to oxidative stress in hepatoma cells.
Carcinoma, Hepatocellular
Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Expression of DNA (5-cytosin)-methyltransferases (DNMTs) in hepatocellular carcinomas.
Carcinoma, Hepatocellular
Expression of proteins upregulated in hepatocellular carcinoma in patients with alcoholic hepatitis (AH) compared to non-alcoholic steatohepatitis (NASH): An immunohistochemical analysis of candidate proteins.
Carcinoma, Hepatocellular
Genome-wide profiling of DNA methylation reveals preferred sequences of DNMTs in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition.
Carcinoma, Hepatocellular
Identification of potential genes regulated by DNA methyltransferase 3B in a hepatocellular carcinoma cell line by RNA interference and microarray analysis.
Carcinoma, Hepatocellular
Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis.
Carcinoma, Hepatocellular
Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas.
Carcinoma, Hepatocellular
Indistinguishable physical and catalytic properties of DNA methyltransferase from normal rat liver and a transplantable rat hepatocellular carcinoma.
Carcinoma, Hepatocellular
Influence of DNA methyltransferase 3b on FHIT expression and DNA methylation of the FHIT promoter region in hepatoma SMMC-7721 cells.
Carcinoma, Hepatocellular
Inhibition of de novo Methyltransferase 3B is a Potential Therapy for Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Inhibition of DNA methyltransferase activity and expression by treatment with the pan-deacetylase inhibitor panobinostat in hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
Integrative Epigenetic Analysis Reveals Therapeutic Targets to the DNA Methyltransferase Inhibitor Guadecitabine (SGI-110) in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Investigation of the Effect of 5-Aza-2'-Deoxycytidine on p15INK4, p16INK4, p18INK4, and p19INK4 Genes Expression, Cell Growth Inhibition, and Apoptosis Induction in Hepatocellular Carcinoma PLC/PRF/5 Cell Line.
Carcinoma, Hepatocellular
Long non-coding RNA HCP5 functions as a sponge of miR-29b-3p and promotes cell growth and metastasis in hepatocellular carcinoma through upregulating DNMT3A.
Carcinoma, Hepatocellular
Long non-coding RNA RBMY2FP promotes proliferation of male hepatocellular carcinoma by directing DNA methylation and activating RBMY1A1 via DNMT1.
Carcinoma, Hepatocellular
Long noncoding RNA DDX11-AS1 epigenetically represses LATS2 by interacting with EZH2 and DNMT1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.
Carcinoma, Hepatocellular
MicroRNA-200b inhibits the proliferation of hepatocellular carcinoma by targeting DNA methyltransferase 3a.
Carcinoma, Hepatocellular
microRNA-450a targets DNA methyltransferase 3a in hepatocellular carcinoma.
Carcinoma, Hepatocellular
miR-200b restoration and DNA methyltransferase inhibitor block lung metastasis of mesenchymal-phenotype hepatocellular carcinoma.
Carcinoma, Hepatocellular
miR-29c-3p regulates DNMT3B and LATS1 methylation to inhibit tumor progression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
MiR-876-5p acts as an inhibitor in hepatocellular carcinoma progression by targeting DNMT3A.
Carcinoma, Hepatocellular
MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers.
Carcinoma, Hepatocellular
Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44+ cancer stem cells to 5 azacytidine in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis.
Carcinoma, Hepatocellular
Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma.
Carcinoma, Hepatocellular
Plasma Cell Polarization to the Immunoglobulin G Phenotype in Hepatocellular Carcinomas Involves Epigenetic Alterations and Promotes Hepatoma Progression in Mice.
Carcinoma, Hepatocellular
Promoter polymorphisms of DNA methyltransferase 3B and risk of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Putative association of DNA methyltransferase 1 (DNMT1) polymorphisms with clearance of HBV infection.
Carcinoma, Hepatocellular
RNA methyltransferase NSUN2 promotes growth of hepatocellular carcinoma cells by regulating fizzy-related-1 in vitro and in vivo.
Carcinoma, Hepatocellular
Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma.
Carcinoma, Hepatocellular
S-adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line.
Carcinoma, Hepatocellular
SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Sera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Significance of incorporation of DNMT1 and HLA-DR? with TNM staging in patients with hepatocellular carcinoma after curative resection.
Carcinoma, Hepatocellular
Single nucleotide polymorphism in DNMT3B promoter and its association with hepatocellular carcinoma in a Moroccan population.
Carcinoma, Hepatocellular
Suppression of metallothionein-I/II expression and its probable molecular mechanisms.
Carcinoma, Hepatocellular
Telomerase reverse transcriptase regulates DNMT3B expression/aberrant DNA methylation phenotype and AKT activation in hepatocellular carcinoma.
Carcinoma, Hepatocellular
The Effect of 5-Aza-2'-Deoxycytidine in Combination to and in Comparison with Vorinostat on DNA Methyltransferases, Histone Deacetylase 1, Glutathione S-Transferase 1 and Suppressor of Cytokine Signaling 1 Genes Expression, Cell Growth Inhibition and Apoptotic Induction in Hepatocellular LCL-PI 11 Cell Line.
Carcinoma, Hepatocellular
Transcriptional and post-transcriptional control of DNA methyltransferase 3B is regulated by phosphatidylinositol 3 kinase/Akt pathway in human hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
Transfection of HCVc improves hTERT expression through STAT3 pathway by epigenetic regulation in Huh7 cells.
Carcinoma, Hepatocellular
Trichostatin A sensitizes hepatoma cells to Taxol more than 5-Aza-dC and dexamethasone.
Carcinoma, Hepatocellular
Ursolic acid inhibited growth of hepatocellular carcinoma HepG2 cells through AMPK?-mediated reduction of DNA methyltransferase 1.
Carcinoma, Hepatocellular
Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP.
Carcinoma, Hepatocellular
ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
[Effects of 5-aza-2'-deoxycytidine on the amount of exosomes and secreted immuno-associated proteins by hepatoma cells]
Carcinoma, Hepatocellular
[High expression of DNMT3B promotes proliferation and invasion of hepatocellular carcinoma cells via Hippo signaling pathway].
Carcinoma, Hepatocellular
[Influence of DNA methyltransferase 3b on the expression of cyclin D1 gene and methylation of its promoters in human hepatocellular carcinoma cells]
Carcinoma, Hepatocellular
[No correlation between the sensitivity to 5-aza-dC and the global DNA methylation level in hepatocellular carcinoma cells]
Carcinoma, Hepatocellular
[Overexpression of DNA-methyltransferases in persistency of cccDNA pool in chronic hepatitis B].
Carcinoma, Mucoepidermoid
DNA methyltransferase 1 expression and promoter methylation of E-cadherin in mucoepidermoid carcinoma.
Carcinoma, Mucoepidermoid
DNA methyltransferase expression is associated with cell proliferation in salivary mucoepidermoid carcinoma.
Carcinoma, Mucoepidermoid
[Effects of Dnmt1 and Dnmt3b in mucoepidermoid carcinoma of salivary glands].
Carcinoma, Neuroendocrine
DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors.
Carcinoma, Non-Small-Cell Lung
A novel DNMT3B subfamily, DeltaDNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Determination of O(6)-Methylguanine DNA Methyltransferase Promoter Methylation in Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value.
Carcinoma, Non-Small-Cell Lung
DNMT1 promotes cell proliferation via methylating hMLH1 and hMSH2 promoters in EGFR-mutated non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Elevated mRNA levels of DNA methyltransferase-1 as an independent prognostic factor in primary nonsmall cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Expression of {Delta}DNMT3B Variants and Its Association with Promoter Methylation of p16 and RASSF1A in Primary Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Hypoxic-stabilized EPAS1 proteins transactivate DNMT1 and cause promoter hypermethylation and transcription inhibition of EPAS1 in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Increased NQO1 but not c-MET and survivin expression in non-small cell lung carcinoma with KRAS mutations.
Carcinoma, Non-Small-Cell Lung
Inhibition of DNA methyltransferase 1 by RNA interference reverses epithelial-mesenchymal transition in highly metastatic 95D lung cancer cells by inhibiting the Wnt signaling pathway.
Carcinoma, Non-Small-Cell Lung
Inhibition of DNA methyltransferase inhibits DNA replication.
Carcinoma, Non-Small-Cell Lung
Interaction Of c-Jun And HOTAIR- Increased Expression Of p21 Converge In Polyphyllin I-Inhibited Growth Of Human Lung Cancer Cells.
Carcinoma, Non-Small-Cell Lung
LncRNA MIR210HG promotes proliferation and invasion of non-small cell lung cancer by upregulating methylation of CACNA2D2 promoter via binding to DNMT1.
Carcinoma, Non-Small-Cell Lung
Methylation of Wnt7a Is Modulated by DNMT1 and Cigarette Smoke Condensate in Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome.
Carcinoma, Non-Small-Cell Lung
Silibinin Synergizes with Histone Deacetylase and DNA Methyltransferase Inhibitors in Up-regulating E-cadherin Expression Together with Inhibition of Migration and Invasion of Human Non-small Cell Lung Cancer Cells.
Carcinoma, Non-Small-Cell Lung
Suppression of DNA methyltransferase 1 levels in head and neck squamous carcinoma cells using small interfering RNA results in growth inhibition and increase in Cdk inhibitor p21.
Carcinoma, Non-Small-Cell Lung
The loss-of-function of DNA methyltransferase 1 by siRNA impairs the growth of non-small cell lung cancer with alleviated side effects via reactivation of RASSF1A and APC in vitro and vivo.
Carcinoma, Non-Small-Cell Lung
The rs1550117 A>G variant in DNMT3A gene promoter significantly increases non-small cell lung cancer susceptibility in a Han Chinese population.
Carcinoma, Non-Small-Cell Lung
[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].
Carcinoma, Non-Small-Cell Lung
[The Relationship of Clinicopathology of p16 in Non-small Cell Lung Cancer and 5-nitrogen impurity-2'-deoxycytidine-nitrogen Impurity on the Influence of p16 Expression in Lung Cancer A549 Cells].
Carcinoma, Ovarian Epithelial
Clinicopathological significance and prognostic value of DNA methyltransferase 1, 3a, and 3b expressions in sporadic epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Immunomodulatory action of the DNA methyltransferase inhibitor SGI-110 in epithelial ovarian cancer cells and xenografts.
Carcinoma, Ovarian Epithelial
[Expression of DNA methyltransferase 1, 3A and 3B mRNA in the epithelial ovarian carcinoma]
Carcinoma, Renal Cell
Aberrant DNA methyltransferase 1 expression in clear cell renal cell carcinoma development and progression.
Carcinoma, Renal Cell
An association between overexpression of DNA methyltransferase 3B4 and clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Combined effects of DNA methyltransferase 1 and 3A polymorphisms and urinary total arsenic levels on the risk for clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma.
Carcinoma, Renal Cell
Demethylating agent 5-aza-2'-deoxycytidine enhances susceptibility of renal cell carcinoma to paclitaxel.
Carcinoma, Renal Cell
DNA methyltransferase inhibitor-mediated apoptosis in the Wnt/?-catenin signal pathway in a renal cell carcinoma cell line.
Carcinoma, Renal Cell
Epigenetic regulation of microRNA expression in renal cell carcinoma.
Carcinoma, Renal Cell
Expression profiling and clinicopathological significance of DNA methyltransferase 1, 3A and 3B in sporadic human renal cell carcinoma.
Carcinoma, Renal Cell
Interleukin 6 induces cell proliferation of clear cell renal cell carcinoma by suppressing hepaCAM via the STAT3-dependent up-regulation of DNMT1 or DNMT3b.
Carcinoma, Renal Cell
Long noncoding RNA ATB participates in the development of renal cell carcinoma by downregulating p53 via binding to DNMT1.
Carcinoma, Renal Cell
MG98, a second-generation DNMT1 inhibitor, in the treatment of advanced renal cell carcinoma.
Carcinoma, Renal Cell
Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study.
Carcinoma, Renal Cell
[Study on the combined therapy of DNA-methyltransferase inhibitor and interferon-alpha/beta for mouse spontaneously arose renal cell carcinoma, and immunological mechanism induced by the therapy]
Carcinoma, Small Cell
DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset.
Carcinoma, Squamous Cell
Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer.
Carcinoma, Squamous Cell
Azacitidine, as a DNMT inhibitor decreases hTERT gene expression and telomerase activity more effective compared with HDAC inhibitor in human Head and neck squamous cell carcinoma cell lines.
Carcinoma, Squamous Cell
Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis.
Carcinoma, Squamous Cell
Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer.
Carcinoma, Squamous Cell
DNA methylation-mediated Klotho silencing is an independent prognostic biomarker of head and neck squamous carcinoma.
Carcinoma, Squamous Cell
DNA methyltransferase 1 inhibits O6-methylguanine-DNAmethyl-transferase-mediated cell growth and metastasis of hypopharyngeal squamous carcinoma.
Carcinoma, Squamous Cell
DNMT1 Enhances the Radiosensitivity of HPV-Positive Head and Neck Squamous Cell Carcinomas via Downregulating SMG1.
Carcinoma, Squamous Cell
Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization.
Carcinoma, Squamous Cell
FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
Carcinoma, Squamous Cell
High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis in Head and Neck Squamous Carcinoma.
Carcinoma, Squamous Cell
Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion.
Carcinoma, Squamous Cell
Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-?.
Carcinoma, Squamous Cell
Lower expression of p14ARF and p16INK4a correlates with higher DNMT3B expression in human oesophageal squamous cell carcinomas.
Carcinoma, Squamous Cell
Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.
Carcinoma, Squamous Cell
Over-expression of DNMT3A predicts the risk of recurrent vulvar squamous cell carcinomas.
Carcinoma, Squamous Cell
Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study.
Carcinoma, Squamous Cell
Promoter polymorphisms of DNMT3B and the risk of head and neck squamous cell carcinoma in Taiwan: a case-control study.
Carcinoma, Squamous Cell
Reprogramming of HeLa cells upon DNMT3L overexpression mimics carcinogenesis.
Carcinoma, Squamous Cell
Suppression of DNA methyltransferase 1 levels in head and neck squamous carcinoma cells using small interfering RNA results in growth inhibition and increase in Cdk inhibitor p21.
Carcinoma, Squamous Cell
Transfer RNA methyltransferase gene NSUN2 mRNA expression modifies the effect of T cell activation score on patient survival in head and neck squamous carcinoma.
Carcinoma, Squamous Cell
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
Carcinoma, Squamous Cell
[Screening and functional analysis of microRNA expression in HPV16-positive squamous carcinoma of the cervix ?in the Uygur of southern Xinjiang].
Carcinoma, Transitional Cell
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma.
Carcinoma, Transitional Cell
Demethylating agent 5-aza-2'-deoxycytidine enhances susceptibility of bladder transitional cell carcinoma to Cisplatin.
Carcinoma, Transitional Cell
Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder.
Cardiomegaly
CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease.
Cardiomegaly
Hypertrophic signaling compensates for contractile and metabolic consequences of DNA methyltransferase 3A loss in human cardiomyocytes.
Cardiomyopathy, Hypertrophic, Familial
Myocardial tissue-specific Dnmt1 knockout in rats protects against pathological injury induced by Adriamycin.
Cardiovascular Diseases
A feedback loop: Interactions between Inflammatory Signals and Clonal Hematopoiesis in Cardiovascular Disease.
Cardiovascular Diseases
Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.
Cardiovascular Diseases
CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease.
Cardiovascular Diseases
Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review.
Cardiovascular Diseases
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Cardiovascular Diseases
Homocysteine inhibits endothelial progenitor cells proliferation via DNMT1-mediated hypomethylation of Cyclin A.
Cataplexy
A novel DNMT1 mutation associated with early onset hereditary sensory and autonomic neuropathy, cataplexy, cerebellar atrophy, scleroderma, endocrinopathy, and common variable immune deficiency.
Cataplexy
Cataplexy and ataxia: red flags for the diagnosis of DNA methyltransferase 1 mutation.
Cataract
Expanding the phenotype of biallelic loss-of-function variants in the NSUN2 gene: Description of four individuals with juvenile cataract, chronic nephritis, or brain anomaly as novel complications.
Cell Transformation, Neoplastic
Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.
Cerebellar Ataxia
A novel de novo exon 21 DNMT1 mutation causes cerebellar ataxia, deafness, and narcolepsy in a Brazilian patient.
Cerebellar Ataxia
A novel DNMT1 mutation associated with early onset hereditary sensory and autonomic neuropathy, cataplexy, cerebellar atrophy, scleroderma, endocrinopathy, and common variable immune deficiency.
Cerebellar Ataxia
Aberrant signature methylome by DNMT1 hot spot mutation in hereditary sensory and autonomic neuropathy 1E.
Cerebellar Ataxia
Autosomal dominant cerebellar ataxia, deafness, and narcolepsy (ADCA-DN) associated with progressive cognitive and behavioral deterioration.
Cerebellar Ataxia
Cerebellar Ataxia as a Common Clinical Presentation Associated with DNMT1 p.Y511H and a Review of the Literature.
Cerebellar Ataxia
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
Cerebellar Ataxia
Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy.
Cerebellar Ataxia
Identification of a novel DNMT1 mutation in a Chinese patient with hereditary sensory and autonomic neuropathy type IE.
Cerebellar Ataxia
Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy.
Cerebellar Ataxia
Novel mutation in the replication focus targeting sequence domain of DNMT1 causes hereditary sensory and autonomic neuropathy IE.
Cerebellar Ataxia
Polysomnographic and neurometabolic features may mark preclinical autosomal dominant cerebellar ataxia, deafness, and narcolepsy due to a mutation in the DNA (cytosine-5-)-methyltransferase gene, DNMT1.
Cervical Intraepithelial Neoplasia
Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization.
Cervical Intraepithelial Neoplasia
Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion.
Cholangiocarcinoma
DNA methyltransferase inhibitor zebularine induces human cholangiocarcinoma cell death through alteration of DNA methylation status.
Cholangiocarcinoma
Dual Targeting of G9a and DNA Methyltransferase-1 for the Treatment of Experimental Cholangiocarcinoma.
Cholangiocarcinoma
miR-29b restrains cholangiocarcinoma progression by relieving DNMT3B-mediated repression of CDKN2B expression.
Cholangiocarcinoma
Suppressing effects of down-regulating DNMT1 and DNMT3b expression on the growth of human cholangiocarcinoma cell line.
Cholangitis
Primary Biliary Cholangitis in British Columbia First Nations: Clinical features and discovery of novel genetic susceptibility loci.
Choline Deficiency
Gestational Choline Deficiency Causes Global and Igf2 Gene DNA Hypermethylation by Up-regulation of Dnmt1 Expression.
Chondrosarcoma
Epigenetic silencing of SFRP5 promotes the metastasis and invasion of chondrosarcoma by expression inhibition and Wnt signaling pathway activation.
Chondrosarcoma
Epigenetics: methylation-associated repression of heparan sulfate 3-O-sulfotransferase gene expression contributes to the invasive phenotype of H-EMC-SS chondrosarcoma cells.
Choriocarcinoma
Curcumol Controls Choriocarcinoma Stem-Like Cells Self-Renewal via Repression of DNA Methyltransferase (DNMT)- and Histone Deacetylase (HDAC)-Mediated Epigenetic Regulation.
Choriocarcinoma
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.
Choriocarcinoma
Production of an anti-angiogenic factor sFLT1 is suppressed via promoter hypermethylation of FLT1 gene in choriocarcinoma cells.
Colitis, Ulcerative
Immunohistochemical analysis of the DNA methyltransferase 3b expression is associated with significant improvements in the discrimination of ulcerative colitis-associated neoplastic lesions.
Colitis, Ulcerative
Increased expression of DNA methyltransferase-1 in non-neoplastic epithelium helps predict colorectal neoplasia risk in ulcerative colitis.
Colitis, Ulcerative
Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients.
Colonic Neoplasms
5-Aza-CdR Regulates RASSF1A By Inhibiting DNMT1 To Affect Colon Cancer Cell Proliferation, Migration And Apoptosis.
Colonic Neoplasms
5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms.
Colonic Neoplasms
A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer.
Colonic Neoplasms
A feasibility study of combined epigenetic and vaccine therapy in advanced colorectal cancer with pharmacodynamic endpoint.
Colonic Neoplasms
A microassay for measuring cytosine DNA methyltransferase activity during tumor progression.
Colonic Neoplasms
A novel miR-203-DNMT3b-ABCG2 regulatory pathway predisposing colorectal cancer development.
Colonic Neoplasms
Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation.
Colonic Neoplasms
Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines.
Colonic Neoplasms
Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells.
Colonic Neoplasms
Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3.
Colonic Neoplasms
Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model.
Colonic Neoplasms
Combination of gefitinib and DNA methylation inhibitor decitabine exerts synergistic anti-cancer activity in colon cancer cells.
Colonic Neoplasms
Correction to "5-aza-Cytidine Is a Potent Inhibitor of DNA Methyltransferase 3a and Induces Apoptosis in HCT-116 Colon Cancer Cells via Gadd45- and p53-Dependent Mechanisms".
Colonic Neoplasms
CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1.
Colonic Neoplasms
Different involvement of DNA methylation and histone deacetylation in the expression of solute-carrier transporters in 4 colon cancer cell lines.
Colonic Neoplasms
DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers.
Colonic Neoplasms
DNA methyltransferase 1 is essential for initiation of the colon cancers.
Colonic Neoplasms
DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer.
Colonic Neoplasms
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells.
Colonic Neoplasms
DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes.
Colonic Neoplasms
DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination.
Colonic Neoplasms
DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer.
Colonic Neoplasms
DNMT3b 39179GT polymorphism and the risk of adenocarcinoma of the colon in Koreans.
Colonic Neoplasms
DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.
Colonic Neoplasms
Effect of 5-Aza-2'-Deoxycytidine in Comparison to Valproic Acid and Trichostatin A on Histone Deacetylase 1, DNA Methyltransferase 1, and CIP/KIP Family (p21, p27, and p57) Genes Expression, Cell Growth Inhibition, and Apoptosis Induction in Colon Cancer SW480 Cell Line.
Colonic Neoplasms
Effect of 5-aza-2'-deoxycytidine on Estrogen Receptor Alpha/Beta and DNA Methyltransferase 1 Genes Expression, Apoptosis Induction, and Cell Growth Prevention of the Colon Cancer HT 29 Cell Line.
Colonic Neoplasms
Effect of 5-aza-2'-deoxycytidine on p27Kip1, p21Cip1/Waf1/Sdi1, p57Kip2, and DNA methyltransferase 1 Genes Expression, Cell Growth Inhibition and Apoptosis Induction in Colon Cancer SW 480 and SW 948 Cell Lines.
Colonic Neoplasms
Effect of Zebularine in Comparison to and in Combination with Trichostatin A on CIP/KIP Family (p21Cip1/Waf1/Sdi1, p27Kip1, and p57Kip2), DNMTs (DNMT1, DNMT3a, and DNMT3b), Class I HDACs (HDACs 1, 2, 3) and Class II HDACs (HDACs 4, 5, 6) Gene Expression, Cell Growth Inhibition and Apoptosis Induction in Colon Cancer LS 174T Cell Line.
Colonic Neoplasms
Effects of DNA methylation on expression of tumor suppressor genes and proto-oncogene in human colon cancer cell lines.
Colonic Neoplasms
Epigenetic mechanisms involved in differential MDR1 mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy.
Colonic Neoplasms
Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A.
Colonic Neoplasms
Frequent Increased Gene Copy Number and High Protein Expression of tRNA (Cytosine-5-)-Methyltransferase (NSUN2) in Human Cancers.
Colonic Neoplasms
FXR silencing in human colon cancer by DNA methylation and KRAS signaling.
Colonic Neoplasms
Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer.
Colonic Neoplasms
Green tea polyphenol epigallocatechin 3-gallate, contributes to the degradation of DNMT3A and HDAC3 in HCT 116 human colon cancer cells.
Colonic Neoplasms
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.
Colonic Neoplasms
High-resolution analysis of the 5'-end transcriptome using a next generation DNA sequencer.
Colonic Neoplasms
Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells.
Colonic Neoplasms
HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors.
Colonic Neoplasms
Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity.
Colonic Neoplasms
Identification of long-range epigenetic silencing on chromosome 15q25 and its clinical implication in gastric cancer.
Colonic Neoplasms
Increased cytosine DNA-methyltransferase activity during colon cancer progression.
Colonic Neoplasms
Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis.
Colonic Neoplasms
Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells.
Colonic Neoplasms
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Colonic Neoplasms
Investigation of the Effect of Zebularine in Comparison to and in Combination with Trichostatin A on p21Cip1/Waf1/ Sdi1, p27Kip1, p57Kip2, DNA Methyltransferases and Histone Deacetylases in Colon Cancer LS 180 Cell Line.
Colonic Neoplasms
Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.
Colonic Neoplasms
Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.
Colonic Neoplasms
MiR-339 and especially miR-766 reactivate the expression of tumor suppressor genes in colorectal cancer cell lines through DNA methyltransferase 3B gene inhibition.
Colonic Neoplasms
Mitoxantrone mediates demethylation and reexpression of cyclin d2, estrogen receptor and 14.3.3sigma in breast cancer cells.
Colonic Neoplasms
PHF21B as a candidate tumor suppressor gene in head and neck squamous cell carcinomas.
Colonic Neoplasms
Re: Schneider-Stock R, Diab-Assef M, Rohrbeck A, Foltzer-Jourdainne C, Boltze C, Hartig R, Schönfeld P, Roessner A, and Gali-Muhtasib H (2005) 5-aza-Cytidine Is a Potent Inhibitor of DNA Methyltransferase 3a and Induces Apoptosis in HCT-116 Colon Cancer Cells via Gadd45- and p53-Dependent Mechanisms. J Pharmacol Exp Ther February 2005 312:525-536; doi:10.1124/jpet.104.074195.
Colonic Neoplasms
Regulation of hMSH2 and hMLH1 expression in the human colon cancer cell line SW1116 by DNA methyltransferase 1.
Colonic Neoplasms
Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells.
Colonic Neoplasms
Role and mechanism of organic cation transporter 3 in oxaliplatin treatment of colon cancer in vitro and in vivo.
Colonic Neoplasms
Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1.
Colonic Neoplasms
Synergistic Effect of Epigenetic Inhibitors Decitabine and Suberoylanilide Hydroxamic Acid on Colorectal Cancer in vitro.
Colonic Neoplasms
Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing.
Colonic Neoplasms
The depletion of DNA Methyltransferase-1 and the epigenetic effects of 5-Aza-2'Deoxycytidine (Decitabine) are differentially regulated by cell cycle progression.
Colonic Neoplasms
The DNMT1-associated lincRNA DACOR1 reprograms genome-wide DNA methylation in colon cancer.
Colonic Neoplasms
The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry.
Colonic Neoplasms
Theaflavin-Containing Black Tea Extract: A Potential DNA Methyltransferase Inhibitor in Human Colon Cancer Cells and Ehrlich Ascites Carcinoma-Induced Solid Tumors in Mice.
Colonic Neoplasms
Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6.
Colonic Neoplasms
Wnt signaling pathway upregulates DNMT1 to trigger NHERF1 promoter hypermethylation in colon cancer.
Colonic Neoplasms
[Effect and mechanism of DNMT inhibitor on the reversal of multidrug resistance in human colon cancer cell line sw620/L-OHP].
Colonic Neoplasms
[Effect of eukaryotic expression plasmid DNA methyltransferase gene on methylation status and transcription level of DNA mismatch repair genes in human colon cancer cell line]
Colonic Neoplasms
[Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines]
Colorectal Neoplasms
A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer.
Colorectal Neoplasms
A protein interaction between beta-catenin and Dnmt1 regulates Wnt Signaling and DNA methylation in colorectal cancer cells.
Colorectal Neoplasms
Aberrant methylation of miR-124 upregulates DNMT3B in colorectal cancer to accelerate invasion and migration.
Colorectal Neoplasms
Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis.
Colorectal Neoplasms
Association of DNMT3B -283 T > C and -579 G > T polymorphisms with decreased cancer risk: evidence from a meta-analysis.
Colorectal Neoplasms
Association of interindividual differences in p14(ARF) promoter methylation with single nucleotide polymorphism in primary colorectal cancer.
Colorectal Neoplasms
Association of the DNMT3A -448A>G polymorphism with genetic susceptibility to colorectal cancer.
Colorectal Neoplasms
Association of the SUV39H1 histone methyltransferase with the DNA methyltransferase 1 at mRNA expression level in primary colorectal cancer.
Colorectal Neoplasms
Chemotherapy and Radiotherapy Downregulate the Activity and Expression of DNA Methyltransferase and Enhance Bcl-2/E1B-19-kDa Interacting Protein-3-Induced Apoptosis in Human Colorectal Cancer Cells.
Colorectal Neoplasms
Circ_0084615 is an oncogenic circular RNA in colorectal cancer and promotes DNMT3A expression via repressing miR-599.
Colorectal Neoplasms
Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies.
Colorectal Neoplasms
Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells.
Colorectal Neoplasms
CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.
Colorectal Neoplasms
CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1.
Colorectal Neoplasms
Curvature-Mediated Surface Accessibility Enables Ultrasensitive Electrochemical Human Methyltransferase Analysis.
Colorectal Neoplasms
De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands.
Colorectal Neoplasms
Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer.
Colorectal Neoplasms
Deep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dysregulation of epithelial-mesenchymal transition and subcellular re-localization of Beta-Catenin.
Colorectal Neoplasms
Different effects of epigenetic modifiers on the cytotoxicity induced by 5-fluorouracil, irinotecan or oxaliplatin in colon cancer cells.
Colorectal Neoplasms
Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation.
Colorectal Neoplasms
Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells.
Colorectal Neoplasms
DNA Electrochemistry Shows DNMT1 Methyltransferase Hyperactivity in Colorectal Tumors.
Colorectal Neoplasms
DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines.
Colorectal Neoplasms
DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target.
Colorectal Neoplasms
DNA Methyltransferase Inhibitors Improve the Effect of Chemotherapeutic Agents in SW48 and HT-29 Colorectal Cancer Cells.
Colorectal Neoplasms
DNA methyltransferases expression in normal tissues and various human cancer cell lines, xenografts and tumors.
Colorectal Neoplasms
DNA-methyltransferase 3B 39179 G > T polymorphism and risk of sporadic colorectal cancer in a subset of Iranian population.
Colorectal Neoplasms
DNMT1 maintains the methylation of miR-152-3p to regulate TMSB10 expression, thereby affecting the biological characteristics of colorectal cancer cells.
Colorectal Neoplasms
DNMT3A -448A>G polymorphism and the risk for hepatocellular carcinoma.
Colorectal Neoplasms
DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells.
Colorectal Neoplasms
DNMT3B -149 C>T and -579 G>T Polymorphisms and Risk of Gastric and Colorectal Cancer: a Meta-analysis.
Colorectal Neoplasms
DNMT3b -149C/T promoter variants and methylation of colorectal cancer-associated genes.
Colorectal Neoplasms
DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.
Colorectal Neoplasms
DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset.
Colorectal Neoplasms
Effects of Amino Acid Substitution Polymorphisms of two DNA Methyltransferases on Susceptibility to Sporadic Colorectal Cancer.
Colorectal Neoplasms
Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells.
Colorectal Neoplasms
Effects of Zebularine on Invasion Activity and Intracellular Expression Level of let-7b in Colorectal Cancer Cells.
Colorectal Neoplasms
Elevated Dnmt3a activity promotes polyposis in Apc(Min) mice by relaxing extracellular restraints on Wnt signaling.
Colorectal Neoplasms
Epigenetic regulation of X-linked cancer/germline antigen genes by DNMT1 and DNMT3b.
Colorectal Neoplasms
Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.
Colorectal Neoplasms
Expression of human DNA methyltransferase 1 in colorectal cancer tissues and their corresponding distant normal tissues.
Colorectal Neoplasms
Frequent Increased Gene Copy Number and High Protein Expression of tRNA (Cytosine-5-)-Methyltransferase (NSUN2) in Human Cancers.
Colorectal Neoplasms
Gene-specific DNA methylation of DNMT3B and MTHFR and colorectal adenoma risk.
Colorectal Neoplasms
Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells.
Colorectal Neoplasms
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Colorectal Neoplasms
Genetic Polymorphism of DNA Methyltransferase 3A rs1550117 A>G and Risk of Cancer: A Meta-analysis.
Colorectal Neoplasms
Genetic polymorphism of DNA methyltransferase 3B 149 C>T and risk of colorectal cancer: a meta-analysis.
Colorectal Neoplasms
Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases.
Colorectal Neoplasms
Genetic Variants of Methyl Metabolizing Enzymes and Epigenetic Regulators: Associations with Promoter CpG Island Hypermethylation in Colorectal Cancer.
Colorectal Neoplasms
Genetic variation in the promoter of DNMT3B is associated with the risk of colorectal cancer.
Colorectal Neoplasms
HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors.
Colorectal Neoplasms
Hsa_circ_0040809 regulates colorectal cancer development by upregulating methyltransferase DNMT1 via targeting miR-515-5p.
Colorectal Neoplasms
IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer.
Colorectal Neoplasms
Impairment of DYRK2 by DNMT1?mediated transcription augments carcinogenesis in human colorectal cancer.
Colorectal Neoplasms
Improved microsatellite instability detection in colorectal cancer patients by a combination of fourteen markers especially DNMT3a, DCD, and MT1X.
Colorectal Neoplasms
Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signaling.
Colorectal Neoplasms
Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling.
Colorectal Neoplasms
Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a.
Colorectal Neoplasms
Label-free electrochemical detection of human methyltransferase from tumors.
Colorectal Neoplasms
LINC00337 promotes tumor angiogenesis in colorectal cancer by recruiting DNMT1, which suppresses the expression of CNN1.
Colorectal Neoplasms
LncRNA HIF1A-AS2 positively affects the progression and EMT formation of colorectal cancer through regulating miR-129-5p and DNMT3A.
Colorectal Neoplasms
Long noncoding RNA LINC00630 promotes radio-resistance by regulating BEX1 gene methylation in colorectal cancer cells.
Colorectal Neoplasms
Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2.
Colorectal Neoplasms
Luteolin induces apoptosis in BE colorectal cancer cells by downregulating calpain, UHRF1, and DNMT1 expressions.
Colorectal Neoplasms
Mechanisms of colon cancer prevention with and beyond COX-2 inhibition.
Colorectal Neoplasms
Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability.
Colorectal Neoplasms
MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events.
Colorectal Neoplasms
MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1.
Colorectal Neoplasms
miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1.
Colorectal Neoplasms
MiR-339 and especially miR-766 reactivate the expression of tumor suppressor genes in colorectal cancer cell lines through DNA methyltransferase 3B gene inhibition.
Colorectal Neoplasms
MiR-410 is overexpressed in liver and colorectal tumors and enhances tumor cell growth by silencing FHL1 via a direct/indirect mechanism.
Colorectal Neoplasms
Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood.
Colorectal Neoplasms
Multiproteomic and Transcriptomic Analysis of Oncogenic ?-Catenin Molecular Networks.
Colorectal Neoplasms
Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer.
Colorectal Neoplasms
Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers.
Colorectal Neoplasms
Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis.
Colorectal Neoplasms
NUSAP1 gene silencing inhibits cell proliferation, migration and invasion through inhibiting DNMT1 gene expression in human colorectal cancer.
Colorectal Neoplasms
Potent antitumor activity of Laccaic acid and Phenethyl isothiocyanate combination in colorectal cancer via dual inhibition of DNA methyltransferase-1 and Histone deacetylase-1.
Colorectal Neoplasms
Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer.
Colorectal Neoplasms
Promoter methylation analysis of WNT/?-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer.
Colorectal Neoplasms
Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas.
Colorectal Neoplasms
Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study.
Colorectal Neoplasms
Protein expression trends of DNMT1 in gastrointestinal diseases: From benign to precancerous lesions to cancer.
Colorectal Neoplasms
Quantitative assessment of AKAP12 promoter methylation in colorectal cancer using methylation-sensitive high resolution melting: Correlation with dukes' stage.
Colorectal Neoplasms
Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks.
Colorectal Neoplasms
Simultaneous silencing Aurora-A and UHRF1 inhibits colorectal cancer cell growth through regulating expression of DNMT1 and STAT1.
Colorectal Neoplasms
The -149C>T polymorphism of DNMT3B is not associated with colorectal cancer risk: Evidence from a meta-analysis based on case-control studies.
Colorectal Neoplasms
The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1.
Colorectal Neoplasms
The role of a ginseng saponin metabolite as a DNA methyltransferase inhibitor in colorectal cancer cells.
Colorectal Neoplasms
Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs.
Colorectal Neoplasms
Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6.
Colorectal Neoplasms
Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress.
Colorectal Neoplasms
[Relationship of DNMT3b expression and SEPT9 methylation in theprogression of colorectal carcinogenesis].
Colorectal Neoplasms, Hereditary Nonpolyposis
DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset.
Common Variable Immunodeficiency
A novel DNMT1 mutation associated with early onset hereditary sensory and autonomic neuropathy, cataplexy, cerebellar atrophy, scleroderma, endocrinopathy, and common variable immune deficiency.
Communicable Diseases
Genotyping of DNA using sequence-specific methyltransferases followed by immunochemical detection.
Congenital Abnormalities
DNA methyltransferase 3a mediates developmental thermal plasticity.
Corneal Injuries
Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes.
Coronary Artery Disease
Risk-Association of DNMT1 Gene Polymorphisms with Coronary Artery Disease in Chinese Han Population.
COVID-19
SARS-CoV-2 Infection-Induced Promoter Hypomethylation as an Epigenetic Modulator of Heat Shock Protein A1L (HSPA1L) Gene.
Cryptorchidism
The Mechanism of Environmental Endocrine Disruptors (DEHP) Induces Epigenetic Transgenerational Inheritance of Cryptorchidism.
Cutis Laxa
Epigenetic silencing of lysyl oxidase-like-1 through DNA hypermethylation in an autosomal recessive cutis laxa case.
Cystic Fibrosis
ALTERATION IN THE CYTOKINE SECRETION PATTERN IN T CELLS OF PATIENTS WITH CYSTIC FIBROSIS CAUSED BY DNA METHYLTRANSFERASE INHIBITOR 5-AZACITIDINE.
Cytomegalovirus Retinitis
Antisense therapy in clinical oncology: preclinical and clinical experiences.
Deafness
A novel de novo exon 21 DNMT1 mutation causes cerebellar ataxia, deafness, and narcolepsy in a Brazilian patient.
Deafness
A novel DNMT1 mutation associated with early onset hereditary sensory and autonomic neuropathy, cataplexy, cerebellar atrophy, scleroderma, endocrinopathy, and common variable immune deficiency.
Deafness
Aberrant signature methylome by DNMT1 hot spot mutation in hereditary sensory and autonomic neuropathy 1E.
Deafness
Autosomal dominant cerebellar ataxia, deafness, and narcolepsy (ADCA-DN) associated with progressive cognitive and behavioral deterioration.
Deafness
Cerebellar Ataxia as a Common Clinical Presentation Associated with DNMT1 p.Y511H and a Review of the Literature.
Deafness
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
Deafness
Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy.
Deafness
Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment.
Deafness
Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy.
Deafness
Novel mutation in the replication focus targeting sequence domain of DNMT1 causes hereditary sensory and autonomic neuropathy IE.
Deafness
Polysomnographic and neurometabolic features may mark preclinical autosomal dominant cerebellar ataxia, deafness, and narcolepsy due to a mutation in the DNA (cytosine-5-)-methyltransferase gene, DNMT1.
Deficiency Diseases
DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangements.
Dehydration
Epigenetic control of the vasopressin promoter explains physiological ability to regulate vasopressin transcription in dehydration and salt loading states in the rat.
Dementia
A novel DNMT1 mutation associated with early onset hereditary sensory and autonomic neuropathy, cataplexy, cerebellar atrophy, scleroderma, endocrinopathy, and common variable immune deficiency.
Dementia
Aberrant signature methylome by DNMT1 hot spot mutation in hereditary sensory and autonomic neuropathy 1E.
Dementia
Association study between the DNMT3A -448A>G polymorphism and risk of Alzheimer's disease in Caucasians of Italian origin.
Dementia
DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?
Dementia
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
Dementia
Lack of association between DNMT1 gene polymorphisms and noise-induced hearing loss in a Chinese population.
Dementia
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.
Dermatitis, Atopic
Social defeat stress exacerbates atopic dermatitis through downregulation of DNA methyltransferase 1 and upregulation of C-C motif chemokine receptor 7 in skin dendritic cells.
Diabetes Complications
Overexpression of Dnmt3a ameliorates diabetic muscle atrophy by modulating Pten/Akt pathway.
Diabetes Mellitus
Overexpression of Dnmt3a ameliorates diabetic muscle atrophy by modulating Pten/Akt pathway.
Diabetes Mellitus, Type 2
Author Correction: NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes.
Diabetes Mellitus, Type 2
Inhibition of DNA methyltransferase 1 increases nuclear receptor subfamily 4 group A member 1 expression and decreases blood glucose in type 2 diabetes.
Diabetes Mellitus, Type 2
NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes.
Diabetic Angiopathies
Transient High Glucose Causes Persistent Vascular Dysfunction and Delayed Wound Healing by the DNMT1-Mediated Ang-1/NF-?B Pathway.
Diabetic Nephropathies
Cissus quadrangularis extract attenuates diabetic nephropathy by altering SIRT1/DNMT1 axis.
Diabetic Nephropathies
DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury.
Diabetic Nephropathies
High glucose-induced cytoplasmic translocation of Dnmt3a contributes to CTGF hypo-methylation in mesangial cells.
Diabetic Nephropathies
Zhang L, Zhang Q, Liu S, et al. DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury. Kidney Int. 2017;92:140-153.
Diabetic Retinopathy
5-aza-2'-deoxycytidine in the regulation of antioxidant enzymes in retinal endothelial cells and rat diabetic retina.
Diabetic Retinopathy
Curcumin Modulates DNA Methyltransferase Functions in a Cellular Model of Diabetic Retinopathy.
dna (cytosine-5-)-methyltransferase deficiency
5-aza-2'-deoxycytidine induces alterations in murine spermatogenesis and pregnancy outcome.
dna (cytosine-5-)-methyltransferase deficiency
A necessary role of DNMT3A in endurance exercise by suppressing ALDH1L1-mediated oxidative stress.
dna (cytosine-5-)-methyltransferase deficiency
Abnormalities of the DNA methylation mark and its machinery: an emerging cause of neurologic dysfunction.
dna (cytosine-5-)-methyltransferase deficiency
Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection.
dna (cytosine-5-)-methyltransferase deficiency
Compromised oocyte quality and assisted reproduction contribute to sex-specific effects on offspring outcomes and epigenetic patterning.
dna (cytosine-5-)-methyltransferase deficiency
Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing.
dna (cytosine-5-)-methyltransferase deficiency
Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.
dna (cytosine-5-)-methyltransferase deficiency
DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals.
dna (cytosine-5-)-methyltransferase deficiency
DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangements.
dna (cytosine-5-)-methyltransferase deficiency
DNA methylation, through DNMT1, has an essential role in the development of gastrointestinal smooth muscle cells and disease.
dna (cytosine-5-)-methyltransferase deficiency
DNA methyltransferase 1 (Dnmt1) mutation affects Snrpn imprinting in the mouse male germ line.
dna (cytosine-5-)-methyltransferase deficiency
DNA methyltransferase 1 and Krüppel-like factor 4 axis regulates macrophage inflammation and atherosclerosis.
dna (cytosine-5-)-methyltransferase deficiency
DNA Methyltransferase 1 Is Indispensable for Development of the Hippocampal Dentate Gyrus.
dna (cytosine-5-)-methyltransferase deficiency
DNA methyltransferase 3a limits the expression of interleukin-13 in T helper 2 cells and allergic airway inflammation.
dna (cytosine-5-)-methyltransferase deficiency
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair.
dna (cytosine-5-)-methyltransferase deficiency
Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells.
dna (cytosine-5-)-methyltransferase deficiency
Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline.
dna (cytosine-5-)-methyltransferase deficiency
DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response.
dna (cytosine-5-)-methyltransferase deficiency
Dnmt1 is required for proximal-distal patterning of the lung endoderm and for restraining alveolar type 2 cell fate.
dna (cytosine-5-)-methyltransferase deficiency
DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics.
dna (cytosine-5-)-methyltransferase deficiency
Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality.
dna (cytosine-5-)-methyltransferase deficiency
Dnmt1-dependent DNA methylation is essential for photoreceptor terminal differentiation and retinal neuron survival.
dna (cytosine-5-)-methyltransferase deficiency
Dnmt3 and G9a cooperate for tissue-specific development in zebrafish.
dna (cytosine-5-)-methyltransferase deficiency
Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.
dna (cytosine-5-)-methyltransferase deficiency
Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway.
dna (cytosine-5-)-methyltransferase deficiency
DNMT3B deficiency alters mitochondrial biogenesis and ?-ketoglutarate levels in human embryonic stem cells.
dna (cytosine-5-)-methyltransferase deficiency
Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice.
dna (cytosine-5-)-methyltransferase deficiency
DNMT3B deficiency presenting as severe combined immune deficiency: A case report.
dna (cytosine-5-)-methyltransferase deficiency
Effects of NSUN2 deficiency on the mRNA 5-methylcytosine modification and gene expression profile in HEK293 cells.
dna (cytosine-5-)-methyltransferase deficiency
Epigenetic alteration of microRNAs in DNMT3B-mutated patients of ICF syndrome.
dna (cytosine-5-)-methyltransferase deficiency
Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis.
dna (cytosine-5-)-methyltransferase deficiency
Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity.
dna (cytosine-5-)-methyltransferase deficiency
Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b.
dna (cytosine-5-)-methyltransferase deficiency
Immunodeficiency, centromeric region instability, facial anomalies syndrome (ICF).
dna (cytosine-5-)-methyltransferase deficiency
Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.
dna (cytosine-5-)-methyltransferase deficiency
Loss of DNMT1o disrupts imprinted X chromosome inactivation and accentuates placental defects in females.
dna (cytosine-5-)-methyltransferase deficiency
Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis.
dna (cytosine-5-)-methyltransferase deficiency
Loss of Dnmt3b accelerates MLL-AF9 leukemia progression.
dna (cytosine-5-)-methyltransferase deficiency
Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism.
dna (cytosine-5-)-methyltransferase deficiency
Maternal Exposure to High-Fat Diet Induces Long-Term Derepressive Chromatin Marks in the Heart.
dna (cytosine-5-)-methyltransferase deficiency
Methylation of the FSHD syndrome-linked subtelomeric repeat in normal and FSHD cell cultures and tissues.
dna (cytosine-5-)-methyltransferase deficiency
Myocardial tissue-specific Dnmt1 knockout in rats protects against pathological injury induced by Adriamycin.
dna (cytosine-5-)-methyltransferase deficiency
Neuronal Dnmt1 Deficiency Attenuates Diet-Induced Obesity in Mice.
dna (cytosine-5-)-methyltransferase deficiency
Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior.
dna (cytosine-5-)-methyltransferase deficiency
NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1.
dna (cytosine-5-)-methyltransferase deficiency
NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment.
dna (cytosine-5-)-methyltransferase deficiency
Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors.
dna (cytosine-5-)-methyltransferase deficiency
Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells.
dna (cytosine-5-)-methyltransferase deficiency
Regulation of somatic cell reprogramming through inducible mir-302 expression.
dna (cytosine-5-)-methyltransferase deficiency
Role of DNMT3B in the regulation of early neural and neural crest specifiers.
dna (cytosine-5-)-methyltransferase deficiency
Selective demethylation and altered gene expression are associated with ICF syndrome in human-induced pluripotent stem cells and mesenchymal stem cells.
dna (cytosine-5-)-methyltransferase deficiency
The extracellular signal-regulated kinase 1/2 modulates the intracellular localization of DNA methyltransferase 3A to regulate erythrocytic differentiation.
dna (cytosine-5-)-methyltransferase deficiency
The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells.
dna (cytosine-5-)-methyltransferase deficiency
Virus-mediated Dnmt1 and Dnmt3a deletion disrupts excitatory synaptogenesis and synaptic function in primary cultured hippocampal neurons.
DNA Repair-Deficiency Disorders
Hypersensitivity to radiation-induced non-apoptotic and apoptotic death in cell lines from patients with the ICF chromosome instability syndrome.
Down Syndrome
DNMT3B promoter polymorphisms and maternal risk of birth of a child with Down syndrome.
Down Syndrome
Maternal risk for down syndrome and polymorphisms in the promoter region of the DNMT3B gene: A case-control study.
Dwarfism
Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions.
Dwarfism
The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes.
Ecchymosis
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease.
Embryo Loss
Generation of chimeric mice with spermatozoa fully derived from embryonic stem cells using a triple-target CRISPR method for Nanos3.
Encephalomyelitis, Autoimmune, Experimental
Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.
Endodermal Sinus Tumor
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.
Endometrial Hyperplasia
Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.
Endometrial Neoplasms
5-Aza-2'-deoxycytidine is a potent inhibitor of DNA methyltransferase 3B and induces apoptosis in human endometrial cancer cell lines with the up-regulation of hMLH1.
Endometrial Neoplasms
Differential Expression and Clinical Significance of DNA Methyltransferase 3B (DNMT3B), Phosphatase and Tensin Homolog (PTEN) and Human MutL Homologs 1 (hMLH1) in Endometrial Carcinomas.
Endometrial Neoplasms
Direct monitoring of breast and endometrial cancer cell epigenetic response to DNA methyltransferase and histone deacetylase inhibitors.
Endometrial Neoplasms
DNA methylation and DNA methyltransferase (DNMT1) activity pattern in endometrial carcinoma.
Endometrial Neoplasms
DNMT Inhibitors and HDAC Inhibitors Regulate E-Cadherin and Bcl-2 Expression in Endometrial Carcinoma in vitro and in vivo.
Endometrial Neoplasms
Down-regulation of miR-145 and miR-143 might be associated with DNA methyltransferase 3B overexpression and worse prognosis in endometrioid carcinomas.
Endometrial Neoplasms
Down-regulation of the progesterone receptor by the methylation of progesterone receptor gene in endometrial cancer cells.
Endometrial Neoplasms
Epigenetic considerations for endometrial cancer prevention, diagnosis and treatment.
Endometrial Neoplasms
Estrogen regulates DNA methyltransferase 3B expression in Ishikawa endometrial adenocarcinoma cells.
Endometrial Neoplasms
Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells.
Endometrial Neoplasms
Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.
Endometrial Neoplasms
LINC00470 Stimulates Methylation of PTEN to Facilitate the Progression of Endometrial Cancer by Recruiting DNMT3a Through MYC.
Endometrial Neoplasms
Loss of exosomal miR-148b from cancer-associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis.
Endometrial Neoplasms
Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers.
Endometrial Neoplasms
Piwil1 causes epigenetic alteration of PTEN gene via upregulation of DNA methyltransferase in type I endometrial cancer.
Endometrial Neoplasms
RG108 induces the apoptosis of endometrial cancer Ishikawa cell lines by inhibiting the expression of DNMT3B and demethylation of HMLH1.
Endometrial Neoplasms
SOX17, ?-catenin and CyclinD1 expression in the endometrioid adenocarcinoma and influence of 5-AZA on expression.
Endometrial Neoplasms
TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer.
Endometrial Neoplasms
Up-regulation of DNA methyltransferase 3B expression in endometrial cancers.
Endometrial Neoplasms
[Characteristic and clinical significance of DNA methyltransferase 3B overexpression in endometrial carcinoma].
Endometriosis
A review of aberrant DNA methylation and epigenetic agents targeting DNA methyltransferase in endometriosis.
Endometriosis
Aberrant expression and localization of deoxyribonucleic acid methyltransferase 3B in endometriotic stromal cells.
Endometriosis
Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis.
Endometriosis
Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility.
Endometriosis
Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis.
Endometriosis
Integrated Bioinformatics Analysis Reveals Function and Regulatory Network of miR-200b-3p in Endometriosis.
Enterovirus Infections
Coxsackievirus B Type 4 Infection in ? Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing.
Epilepsy
DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures.
Epilepsy
Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.
Epilepsy
Identification of De Novo DNMT3A Mutations That Cause West Syndrome by Using Whole-Exome Sequencing.
Epilepsy
Increased Expression of DNA methyltransferase 1 and 3a in Human Temporal Lobe Epilepsy.
Epilepsy
Methyl-CpG-Binding Domain Protein 3 Promotes Seizures by Recruiting Methyltransferase DNMT1 to Enhance TREM2 Methylation.
Epilepsy, Temporal Lobe
Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.
Epilepsy, Temporal Lobe
Increased Expression of DNA methyltransferase 1 and 3a in Human Temporal Lobe Epilepsy.
Epstein-Barr Virus Infections
Association between human papillomavirus and Epstein - Barr virus DNA and gene promoter methylation of RB1 and CDH1 in the cervical lesions: a transversal study.
Epstein-Barr Virus Infections
Correlation between DNA methyltransferases expression and Epstein-Barr virus, JC polyomavirus and Helicobacter pylori infections in gastric carcinomas.
Epstein-Barr Virus Infections
Epigenetic and Transcriptional Changes Which Follow Epstein-Barr Virus Infection of Germinal Center B Cells and Their Relevance to the Pathogenesis of Hodgkin's Lymphoma.
Epstein-Barr Virus Infections
Identifying Key Genes for Nasopharyngeal Carcinoma by Prioritized Consensus Differentially Expressed Genes Caused by Aberrant Methylation.
Epstein-Barr Virus Infections
Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers.
Esophageal Neoplasms
Aberrant Methylation-Mediated Silencing of lncRNA MEG3 Functions as a ceRNA in Esophageal Cancer.
Esophageal Neoplasms
Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-beta2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A.
Esophageal Neoplasms
Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells.
Esophageal Neoplasms
DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells.
Esophageal Neoplasms
DNMT3B 579 G>T promoter polymorphism and risk of esophagus carcinoma in Chinese.
Esophageal Neoplasms
Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+T cells against esophageal carcinoma.
Esophageal Neoplasms
High expression of DNA methyltransferase 1 in Kazakh esophageal epithelial cells may promote malignant transformation induced by N-methyl-N'-nitro-N-nitrosoguanidine.
Esophageal Neoplasms
Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.
Esophageal Neoplasms
miR-148a-3p Suppresses the Proliferation and Invasion of Esophageal Cancer by Targeting DNMT1.
Esophageal Neoplasms
Single nucleotide polymorphisms of one-carbon metabolism and cancers of the esophagus, stomach, and liver in a Chinese population.
Esophageal Neoplasms
The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Activation of PAR4 Upregulates p16 through Inhibition of DNMT1 and HDAC2 Expression via MAPK Signals in Esophageal Squamous Cell Carcinoma Cells.
Esophageal Squamous Cell Carcinoma
DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells.
Esophageal Squamous Cell Carcinoma
Effects of DNA methyltransferase 1 inhibition on esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization.
Esophageal Squamous Cell Carcinoma
piR-823 demonstrates tumor oncogenic activity in esophageal squamous cell carcinoma through DNA methylation induction via DNA methyltransferase 3B.
Esophageal Squamous Cell Carcinoma
Silencing DNA methyltransferase 1 (DNMT1) inhibits proliferation, metastasis and invasion in ESCC by suppressing methylation of RASSF1A and DAPK.
Esophageal Squamous Cell Carcinoma
Silencing DNA methyltransferase 1 leads to the activation of the esophageal suppressor gene p16 in vitro and in vivo.
Esophageal Squamous Cell Carcinoma
The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma.
Essential Hypertension
Polymorphism of the DNA methyltransferase 1 gene is associated with the susceptibility to essential hypertension in male.
Fatty Liver
Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A.
Fatty Liver
MicroRNA-29a Disrupts DNMT3b to Ameliorate Diet-Induced Non-Alcoholic Steatohepatitis in Mice.
Fetal Alcohol Spectrum Disorders
High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.
Fetal Growth Retardation
Effects of Folic Acid on DNMT1, GAP43, and VEGFR1 in Intrauterine Growth Restriction Filial Rats.
Fetal Growth Retardation
Epigenetic regulation of placental glucose transporters mediates maternal cadmium-induced fetal growth restriction.
Fibroadenoma
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis.
Fibrosarcoma
DNA hypermethylation near the transcription start site of collagen alpha2(I) gene occurs in both cancer cell lines and primary colorectal cancers.
Fibrosarcoma
Retention of unmethylated CpG island alleles in human diploid fibroblast x fibrosarcoma hybrids expressing high levels of DNA methyltransferase.
Frontotemporal Dementia
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
Frontotemporal Dementia
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Gallbladder Neoplasms
c?Jun suppresses the expression of WNT inhibitory factor 1 through transcriptional regulation and interaction with DNA methyltransferase 1 in gallbladder cancer.
Gallbladder Neoplasms
NOP2/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL6 in gallbladder carcinoma.
Gastritis
Protein expression trends of DNMT1 in gastrointestinal diseases: From benign to precancerous lesions to cancer.
Gastritis, Atrophic
Protein expression trends of DNMT1 in gastrointestinal diseases: From benign to precancerous lesions to cancer.
Gastrointestinal Diseases
Protein expression trends of DNMT1 in gastrointestinal diseases: From benign to precancerous lesions to cancer.
GATA2 Deficiency
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
Genetic Diseases, Inborn
'Plug and play' microelectrode assisted with Y-motif-mediated primer-free cyclic signal amplification for sensitive quantitation of DNA methyltransferase activity.
Genetic Diseases, Inborn
Coupling hybridization chain reaction with DNAzyme recycling for enzyme-free and dual amplified sensitive fluorescent detection of methyltransferase activity.
Genetic Diseases, Inborn
Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells.
Genetic Diseases, Inborn
Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants.
Genetic Diseases, Inborn
Selective demethylation and altered gene expression are associated with ICF syndrome in human-induced pluripotent stem cells and mesenchymal stem cells.
Genetic Diseases, Inborn
Structural basis of specific DNA binding by the transcription factor ZBTB24.
Genetic Diseases, Inborn
[Diversity of hereditary pathology in the population of Marii El Republic and its differentiation with respect to gene frequencies for hereditary diseases]
Genetic Diseases, Inborn
[Genetic epidemiological study of Bashkortostan Republic: the effect of genetic structure of population on the load of monogenic hereditary diseases]
Genetic Diseases, Inborn
[Medico-genetic study of residents of Marii El republic: burden of hereditary diseases in four regions of the republic]
Germinoma
Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance.
Glioblastoma
A five-miRNA signature with prognostic and predictive value for MGMT promoter-methylated glioblastoma patients.
Glioblastoma
A methylation-specific and SYBR-green-based quantitative polymerase chain reaction technique for O6-methylguanine DNA methyltransferase promoter methylation analysis.
Glioblastoma
Aldehyde dehydrogenase 1A1--a new mediator of resistance to temozolomide in glioblastoma.
Glioblastoma
Association of molecular marker O(6)Methylguanine DNA methyltransferase and concomitant chemoradiotherapy with survival in Southern Chinese glioblastoma patients.
Glioblastoma
c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas.
Glioblastoma
Combination treatment with doxorubicin and microRNA-21 inhibitor synergistically augments anticancer activity through upregulation of tumor suppressing genes.
Glioblastoma
Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM.
Glioblastoma
Correlation of apparent diffusion coefficient values measured by diffusion MRI and MGMT promoter methylation semiquantitatively analyzed with MS-MLPA in patients with glioblastoma multiforme.
Glioblastoma
Distinct demographic profile and molecular markers of primary CNS tumor in 1873 adolescent and young adult patient population.
Glioblastoma
Effect of O6-Substitued Guanine Analogs on O6-Methylguanine DNA-Methyltransferase Expression and Glioblastoma Cells Viability.
Glioblastoma
Efficiency and safety of O?-methylguanine DNA methyltransferase (MGMT(P140K))-mediated in vivo selection in a humanized mouse model.
Glioblastoma
Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51.
Glioblastoma
Epigallocatechin Gallate Preferentially Inhibits O6-Methylguanine DNA-Methyltransferase Expression in Glioblastoma Cells Rather than in Nontumor Glial Cells.
Glioblastoma
FM19G11 inhibits O6 -methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions.
Glioblastoma
Genetic and environmental determinants of O6-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins.
Glioblastoma
Glycogen synthase kinase 3? inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling.
Glioblastoma
High incidence of low O(6)-methylguanine DNA methyltransferase expression in invasive macroadenomas of Cushing's disease.
Glioblastoma
IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma.
Glioblastoma
Immunohistochemical evaluation of O(6) -methylguanine DNA methyltransferase (MGMT) expression in 117 cases of glioblastoma.
Glioblastoma
Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma.
Glioblastoma
Intratumoral homogeneity of MGMT promoter hypermethylation as demonstrated in serial stereotactic specimens from anaplastic astrocytomas and glioblastomas.
Glioblastoma
Is the prognostic significance of O6-methylguanine- DNA methyltransferase promoter methylation equally important in glioblastomas of patients from different continents? A systematic review with meta-analysis.
Glioblastoma
Lentiviral MGMT(P140K)-mediated in vivo selection employing a ubiquitous chromatin opening element (A2UCOE) linked to a cellular promoter.
Glioblastoma
Loss of pericentromeric DNA methylation pattern in human glioblastoma is associated with altered DNA methyltransferases expression and involves the stem cell compartment.
Glioblastoma
MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis.
Glioblastoma
Methylation of O6-methylguanine DNA methyltransferase and loss of heterozygosity on 19q and/or 17p are overlapping features of secondary glioblastomas with prolonged survival.
Glioblastoma
MGMT-Independent Temozolomide Resistance in Pediatric Glioblastoma Cells Associated with a PI3-Kinase-Mediated HOX/Stem Cell Gene Signature.
Glioblastoma
miR-148-3p Inhibits Growth of Glioblastoma Targeting DNA Methyltransferase-1 (DNMT1).
Glioblastoma
miR-29s inhibit the malignant behavior of U87MG glioblastoma cell line by targeting DNMT3A and 3B.
Glioblastoma
Mutant TP53 enhances the resistance of glioblastoma cells to temozolomide by up-regulating O(6)-methylguanine DNA-methyltransferase.
Glioblastoma
Newly Synthesized DNA Methyltransferase Inhibitors as Radiosensitizers for Human Lung Cancer and Glioblastoma Cells.
Glioblastoma
O (6)-Methylguanine DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression is correlated with progression-free survival in patients with glioblastoma.
Glioblastoma
O(6)-Methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma.
Glioblastoma
O(6)-methylguanine DNA-methyltransferase methylation status can change between first surgery for newly diagnosed glioblastoma and second surgery for recurrence: clinical implications.
Glioblastoma
O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients.
Glioblastoma
O6-Methylguanine DNA Methyltransferase Status Does Not Predict Response or Resistance to Alkylating Agents in Well-Differentiated Pancreatic Neuroendocrine Tumors.
Glioblastoma
Outlining involvement of stem cell program in regulation of O6-methylguanine DNA methyltransferase and development of temozolomide resistance in glioblastoma: An Editorial Highlight for 'Transcriptional control of O6 -methylguanine DNA methyltransferase expression and temozolomide resistance in glioblastoma' on page 780.
Glioblastoma
Phase 1 Study of Preoperative Chemoradiation Therapy With Temozolomide and Capecitabine in Patients With Locally Advanced Rectal Cancer.
Glioblastoma
Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells.
Glioblastoma
Radiosensitization of Glioblastoma Cells by a Novel DNA Methyltransferase-inhibiting Phthalimido-Alkanamide Derivative.
Glioblastoma
RCC2 promotes proliferation and radio-resistance in glioblastoma via activating transcription of DNMT1.
Glioblastoma
Recurrent Glioblastoma: Combination of High Cerebral Blood Flow with MGMT Promoter Methylation Is Associated with Benefit from Low-Dose Temozolomide Rechallenge at First Recurrence.
Glioblastoma
Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation.
Glioblastoma
Should biomarkers be used to design personalized medicine for the treatment of glioblastoma?
Glioblastoma
Specific Inhibition of DNMT3A/ISGF3? Interaction Increases the Temozolomide Efficiency to Reduce Tumor Growth.
Glioblastoma
Status of O? -methylguanine-DNA methyltransferase [MGMT] gene promoter methylation among patients with glioblastomas from India.
Glioblastoma
The Changes in MGMT Promoter Methylation Status in Initial and Recurrent Glioblastomas.
Glioblastoma
The Clinical Implications of Inconsistently Methylated Results from Glioblastoma MGMT Testing by Replicate Methylation-Specific PCR.
Glioma
20(S)-ginsenoside-Rg3 reverses temozolomide resistance and restrains epithelial-mesenchymal transition progression in glioblastoma.
Glioma
A new tumor suppressor LncRNA ADAMTS9-AS2 is regulated by DNMT1 and inhibits migration of glioma cells.
Glioma
c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas.
Glioma
Clinical and Molecular Characteristics of Thalamic Gliomas: Retrospective Report of 26 Cases.
Glioma
Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas.
Glioma
Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells.
Glioma
DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA.
Glioma
DNMT1 mediates chemosensitivity by reducing methylation of miRNA-20a promoter in glioma cells.
Glioma
DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NF?B complex in the (de-)methylation of TRAF1.
Glioma
Downregulation of KLF13 through DNMT1-mediated hypermethylation promotes glioma cell proliferation and invasion.
Glioma
Epigenetic downregulation of STAT6 increases HIF-1? expression via mTOR/S6K/S6, leading to enhanced hypoxic viability of glioma cells.
Glioma
Epigenetic modification of miR-141 regulates SKA2 by an endogenous 'sponge' HOTAIR in glioma.
Glioma
Epigenetic repression of long non-coding RNA MEG3 mediated by DNMT1 represses the p53 pathway in gliomas.
Glioma
Erratum to: Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B in gliomas.
Glioma
Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors.
Glioma
Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma.
Glioma
Impact on prognosis of the regional distribution of MGMT methylation with respect to the CpG island methylator phenotype and age in glioma patients.
Glioma
Interferon-? Induces Loss of Spherogenicity and Overcomes Therapy Resistance of Glioblastoma Stem Cells.
Glioma
Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas.
Glioma
Long Noncoding RNA LINC00467 Promotes Glioma Progression through Inhibiting P53 Expression via Binding to DNMT1.
Glioma
Long noncoding RNA NEAT1 promotes progression of glioma as a ceRNA by sponging miR-185-5p to stimulate DNMT1/mTOR signaling.
Glioma
Methylation-induced downregulation and tumor-suppressive role of microRNA-98 in glioma through targeting Sal-like protein 4.
Glioma
Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines.
Glioma
MicroRNA-129-5p inhibits human glioma cell proliferation and induces cell cycle arrest by directly targeting DNMT3A.
Glioma
miR-148-3p Inhibits Growth of Glioblastoma Targeting DNA Methyltransferase-1 (DNMT1).
Glioma
miR-152 regulated glioma cell proliferation and apoptosis via Runx2 mediated by DNMT1.
Glioma
O6 -methylguanine DNA methyltransferase gene promoter methylation in high-grade gliomas: a review of current status.
Glioma
PDCD4 gene silencing in gliomas is associated with 5'CpG island methylation and unfavorable prognosis.
Glioma
Quantitative analysis of O(6)-methylguanine DNA methyltransferase (MGMT) promoter methylation in patients with low-grade gliomas.
Glioma
Regulation of human glioma cell apoptosis and invasion by miR-152-3p through targeting DNMT1 and regulating NF2 : MiR-152-3p regulate glioma cell apoptosis and invasion.
Glioma
Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation.
Glioma
Relationship between MGMT gene expression and treatment effectiveness and prognosis in glioma.
Glioma
Repression of Dok7 expression mediated by DNMT1 promotes glioma cells proliferation.
Glioma
Synergistic induction of NY-ESO-1 antigen expression by a novel histone deacetylase inhibitor, valproic acid, with 5-aza-2'-deoxycytidine in glioma cells.
Glioma
Tumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas.
Glioma
Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma.
Gliosarcoma
O(6)-methylguanine DNA methyltransferase status determined by promoter methylation and immunohistochemistry in gliosarcoma and their clinical implications.
Glomerulonephritis, IGA
Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura.
Glucose Intolerance
Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance.
Glycogen Storage Disease
Whole exome sequencing unravels disease-causing genes in consanguineous families in Qatar.
Gonadal Dysgenesis
DNA analysis of a patient with two different marker chromosomes using Y-specific DNA probes.
Graft vs Host Disease
Graft-versus-host disease after liver transplantation is associated with bone marrow failure, hemophagocytosis, and DNMT3A mutations.
Hallux Valgus
Further delineation of autosomal recessive intellectual disability syndrome caused by homozygous variant of the NSUN2 gene in a chinese pedigree.
Head and Neck Neoplasms
A novel C/T polymorphism in the core promoter of human de novo cytosine DNA methyltransferase 3B6 is associated with prognosis in head and neck cancer.
Head and Neck Neoplasms
Association of DNMT3B -283 T > C and -579 G > T polymorphisms with decreased cancer risk: evidence from a meta-analysis.
Head and Neck Neoplasms
DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.
Head and Neck Neoplasms
EPHA3 Contributes to Epigenetic Suppression of PTEN in Radioresistant Head and Neck Cancer.
Head and Neck Neoplasms
Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
Head and Neck Neoplasms
HPV Infection Leaves a DNA Methylation Signature in Oropharyngeal Cancer Affecting Both Coding Genes and Transposable Elements.
Head and Neck Neoplasms
Polymorphism of DNA methyltransferase 3B -149C/T and cancer risk: a meta-analysis.
Hearing Loss
A Patient With DNMT1 Gene Mutation Presenting With Polyneuropathy, Hearing Loss, and Personality Changes.
Hearing Loss
Aberrant signature methylome by DNMT1 hot spot mutation in hereditary sensory and autonomic neuropathy 1E.
Hearing Loss
DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?
Hearing Loss
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
Hearing Loss
Identification of a novel DNMT1 mutation in a Chinese patient with hereditary sensory and autonomic neuropathy type IE.
Hearing Loss
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.
Hearing Loss, Noise-Induced
DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers.
Hearing Loss, Noise-Induced
Lack of association between DNMT1 gene polymorphisms and noise-induced hearing loss in a Chinese population.
Hearing Loss, Noise-Induced
The DNA methylation inhibitor RG108 protects against noise-induced hearing loss.
Hearing Loss, Noise-Induced
[Association between SNPs in DNMT1 and noise-induced hearing loss in Chinese Han population].
Hearing Loss, Noise-Induced
[Association of DNMT3a's single nucleotide polymorphisms with susceptibility to noise-induced hearing loss in Chinese workers].
Hearing Loss, Sensorineural
Lack of association between DNMT1 gene polymorphisms and noise-induced hearing loss in a Chinese population.
Heart Defects, Congenital
Association of DNMT1 Gene Polymorphisms with Congenital Heart Disease in Child Patients.
Heart Failure
Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure.
Heart Failure
Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations.
Heart Failure
Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.
Heart Failure
Experimental heart failure modelled by the cardiomyocyte-specific loss of an epigenome modifier, DNMT3B.
Heart Failure
Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality.
Heart Failure
Histone deacetylase 3 suppresses the expression of SHP-1 via deacetylation of DNMT1 to promote heart failure.
Heart Failure
Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure.
Heart Septal Defects, Ventricular
Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome.
Hemangioma
MiR-206 promotes extracellular matrix accumulation and relieves infantile hemangioma through targeted inhibition of DNMT3A.
Hemangiosarcoma
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma.
Hematologic Diseases
5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair.
Hematologic Diseases
Screening for mutation R882 in the DNMT3A gene in Chinese patients with hematological disease.
Hematologic Diseases
Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor.
Hematologic Neoplasms
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells.
Hematologic Neoplasms
A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer.
Hematologic Neoplasms
Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing.
Hematologic Neoplasms
Activation of a Subset of Evolutionarily Young Transposable Elements and Innate Immunity Are Linked to Clinical Responses to 5-Azacytidine.
Hematologic Neoplasms
Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine in anaplastic large cell lymphoma.
Hematologic Neoplasms
Azacytidine induces cell cycle arrest and suppression of neuroendocrine markers in carcinoids.
Hematologic Neoplasms
Biological background of the genomic variations of cf-DNA in healthy individuals.
Hematologic Neoplasms
Characterization of decomposition products and preclinical and low dose clinical pharmacokinetics of decitabine (5-aza-2'-deoxycytidine) by a new liquid chromatography/tandem mass spectrometry quantification method.
Hematologic Neoplasms
Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies.
Hematologic Neoplasms
Cost-effective screening of DNMT3A coding sequence identifies somatic mutation in pediatric T-cell acute lymphoblastic leukemia.
Hematologic Neoplasms
Decitabine: development of a DNA methyltransferase inhibitor for hematological malignancies.
Hematologic Neoplasms
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
Hematologic Neoplasms
Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem/progenitor cells.
Hematologic Neoplasms
DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine.
Hematologic Neoplasms
DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4+CD25high FOXP3+ Regulatory T Cells but Does Not Affect Their Suppressive Capacity.
Hematologic Neoplasms
Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model.
Hematologic Neoplasms
Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma.
Hematologic Neoplasms
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.
Hematologic Neoplasms
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
Hematologic Neoplasms
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.
Hematologic Neoplasms
Efficacy and safety of extended dosing schedules of CC-486 (oral azacitidine) in patients with lower-risk myelodysplastic syndromes.
Hematologic Neoplasms
Epigenetic pathways in macrophages emerge as novel targets in atherosclerosis.
Hematologic Neoplasms
Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries.
Hematologic Neoplasms
Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia.
Hematologic Neoplasms
Inhibition of DNMT1 and ERR? crosstalk suppresses breast cancer via derepression of IRF4.
Hematologic Neoplasms
MiR-10a and HOXB4 are overexpressed in atypical myeloproliferative neoplasms.
Hematologic Neoplasms
Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer.
Hematologic Neoplasms
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Hematologic Neoplasms
Mutational and transcriptomic profiling of acute leukemia of ambiguous lineage reveals obscure but clinically important lineage bias.
Hematologic Neoplasms
Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability.
Hematologic Neoplasms
Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome.
Hematologic Neoplasms
Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a.
Hematologic Neoplasms
Rapid detection of DNMT3A R882 mutations in hematologic malignancies using a novel bead-based suspension assay with BNA(NC) probes.
Hematologic Neoplasms
Targeting DNA methylation for treating triple-negative breast cancer.
Hematologic Neoplasms
Targeting epigenetics for the treatment of prostate cancer: recent progress and future directions.
Hematologic Neoplasms
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors.
Hematologic Neoplasms
The extracellular signal-regulated kinase 1/2 modulates the intracellular localization of DNA methyltransferase 3A to regulate erythrocytic differentiation.
Hematologic Neoplasms
The spectrum of DNMT3A variants in Tatton-Brown-Rahman syndrome overlaps with that in hematologic malignancies.
Hematologic Neoplasms
[Genomic aberrations in myelodysplastic syndromes and related disorders].
Hemoglobinopathies
In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor.
Hepatitis
Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A.
Hepatitis B
Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1.
Hepatitis B
Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A.
Hepatitis B
Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway.
Hepatitis B
Glucocorticoid-induced S-adenosylmethionine enhances the interferon signaling pathway by restoring STAT1 protein methylation in hepatitis B virus-infected cells.
Hepatitis B
Hepatitis B virus can be inhibited by DNA methyltransferase 3a via specific zinc-finger-induced methylation of the X promoter.
Hepatitis B
Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1.
Hepatitis B
Hepatitis B virus X protein upregulates DNA methyltransferase 3A/3B and enhances SOCS-1CpG island methylation.
Hepatitis B
miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A.
Hepatitis B
Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma.
Hepatitis B
Sera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma.
Hepatitis B, Chronic
DNMT1 modulation in chronic hepatitis B patients and hypothetic influence on mitochondrial DNA methylation status during long-term nucleo(t)side analogs therapy.
Hepatitis B, Chronic
Impact of hepatitis virus and aging on DNA methylation in human hepatocarcinogenesis.
Hepatitis B, Chronic
Sera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma.
Hepatitis C
DNA methyltransferase 1, 3a, and 3b expression in hepatitis C associated human hepatocellular carcinoma and their clinicopathological association.
Hepatitis C
Hepatitis C virus core protein downregulates E-cadherin expression via activation of DNA methyltransferase 1 and 3b.
Hepatitis C
Ribavirin restores ESR1 gene expression and tamoxifen sensitivity in ESR1 negative breast cancer cell lines.
Hepatitis, Chronic
DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation.
Hepatitis, Chronic
Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis.
Hepatitis, Chronic
Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis.
Hepatitis, Chronic
Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas.
Hepatitis, Chronic
Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis.
Hepatoblastoma
Epigenetic reprogramming modulates malignant properties of human liver cancer.
Hepatoblastoma
Methylation of episomal plasmids as a barrier to transient gene expression via a synthetic delivery vector.
Hepatomegaly
Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.
Hepatomegaly
The effect of phenobarbital on the methylation level of the p16 promoter region in rat liver.
Hereditary Sensory and Autonomic Neuropathies
DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?
Hereditary Sensory and Autonomic Neuropathies
DNMT1 links aberrant DNA methylation to hereditary sensory neuropathy.
Hereditary Sensory and Autonomic Neuropathies
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.
Hereditary Sensory and Autonomic Neuropathies
Narcolepsy is a common phenotype in HSAN IE and ADCA-DN.
Hereditary Sensory and Autonomic Neuropathies
Novel mutation in the replication focus targeting sequence domain of DNMT1 causes hereditary sensory and autonomic neuropathy IE.
Hereditary Sensory and Motor Neuropathy
Genetic and phenotypic characterization of complex hereditary spastic paraplegia.
Herpes Zoster
Expression patterns of dnmt3aa, dnmt3ab, and dnmt4 during development and fin regeneration in zebrafish.
Hidradenitis
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease.
Hirschsprung Disease
Involvement of DNMT3B in the pathogenesis of Hirschsprung disease and its possible role as a regulator of neurogenesis in the human enteric nervous system.
Hirschsprung Disease
Overexpression of DNMT3b target genes during Enteric Nervous System development contribute to the onset of Hirschsprung disease.
HIV Infections
Epigenetic regulation of RCAN1 expression in kidney disease and its role in podocyte injury.
HIV Infections
HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene.
Hyperandrogenism
Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism.
Hypereosinophilic Syndrome
Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins.
Hyperglycemia
Regulation of MDA-MB-231 cell proliferation by GSK-3? involves epigenetic modifications under high glucose conditions.
Hyperglycemia
Transient High Glucose Causes Persistent Vascular Dysfunction and Delayed Wound Healing by the DNMT1-Mediated Ang-1/NF-?B Pathway.
Hyperhomocysteinemia
Reciprocal Regulation Between miR-148a/152 and DNA Methyltransferase 1 Is Associated with Hyperhomocysteinemia-Accelerated Atherosclerosis.
Hyperhomocysteinemia
[Effects and related mechanism of 5-aza-2'-deoxycytidine on endothelial function in rats with hyperhomocysteinemia].
Hyperlipidemias
DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics.
Hypersensitivity
Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation.
Hypersensitivity
Contribution of DNMT1 to Neuropathic Pain Genesis Partially through Epigenetically Repressing Kcna2 in Primary Afferent Neurons.
Hypersensitivity
DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1.2 expression in spinal cord dorsal horn.
Hypersensitivity
Epigenetic control of hypersensitivity in chronic inflammatory pain by the de novo DNA methyltransferase Dnmt3a2.
Hypersensitivity
Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury.
Hypersensitivity
High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors.
Hypersensitivity
Nerve Injury-Induced Chronic Pain Is Associated with Persistent DNA Methylation Reprogramming in Dorsal Root Ganglion.
Hypersensitivity
Reciprocal epigenetic remodeling controls testicular cancer hypersensitivity to hypomethylating agents and chemotherapy.
Hypersensitivity
Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine.
Hypertension
Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure.
Hypertension, Pulmonary
DNA methyltransferase 3B deficiency unveils a new pathological mechanism of pulmonary hypertension.
Hyperthyroidism
Alterations of Global DNA Methylation and DNA Methyltransferase Expression in T and B Lymphocytes from Patients with Newly Diagnosed Autoimmune Thyroid Diseases After Treatment: A Follow-Up Study.
Hypertrophy, Right Ventricular
DNA methyltransferase 3B deficiency unveils a new pathological mechanism of pulmonary hypertension.
Hypothyroidism
MTHFR GENE C677T POLYMORPHISM AND LEVELS OF DNA METHYLTRASFERASES IN SUBCLINICAL HYPOTHYROIDISM.
Immune System Diseases
Two siblings with immunodeficiency, facial abnormalities and chromosomal instability without mutation in DNMT3B gene but liability towards malignancy; a new chromatin disorder delineation?
Infections
An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection.
Infections
Association of Clonal Hematopoiesis of Indeterminate Potential With Inflammatory Gene Expression in Patients With Severe Degenerative Aortic Valve Stenosis or Chronic Postischemic Heart Failure.
Infections
Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan.
Infections
Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection.
Infections
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFN? signaling.
Infections
Correlation between DNA methyltransferases expression and Epstein-Barr virus, JC polyomavirus and Helicobacter pylori infections in gastric carcinomas.
Infections
Crosstalk between histone modification and DNA methylation orchestrates the epigenetic regulation of the costimulatory factors, Tim?3 and galectin?9, in cervical cancer.
Infections
Cytosine methylation by DNMT2 facilitates stability and survival of HIV-1 RNA in the host cell during infection.
Infections
Distinct Roles of Two DNA Methyltransferases from Cryphonectria parasitica in Fungal Virulence, Responses to Hypovirus Infection, and Viral Clearance.
Infections
DNA Methylation Fluctuation Induced by Virus Infection Differs between MD-resistant and -susceptible Chickens.
Infections
DNA methyltransferase inhibitors increase baculovirus-mediated gene expression in mammalian cells when applied before infection.
Infections
DNA methyltransferases 1 and 3B are required for hepatitis C virus infection in cell culture.
Infections
DNMT gene expression and methylome in Marek's disease resistant and susceptible chickens prior to and following infection by MDV.
Infections
DNMT3a rs1550117 polymorphism association with increased risk of Helicobacter pylori infection.
Infections
Enterovirus 71 Suppresses miR-17-92 Cluster Through Up-Regulating Methylation of the miRNA Promoter.
Infections
Escherichia coli bacteriophage T1 DNA methyltransferase appears to interact with Escherichia coli enolase.
Infections
Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection.
Infections
Global and Complement Gene-Specific DNA Methylation in Grass Carp after Grass Carp Reovirus (GCRV) Infection.
Infections
Haemophagocytic lymphohistiocytosis occurred during induction chemotherapy in an acute monocytic leukemia patient with FLT3-ITD and DNMT3A mutations.
Infections
Hematopoietic Stem Cell Transplantation Corrects the Immunologic Abnormalities Associated With Immunodeficiency Centromeric Instability Facial Dysmorphism Syndrome.
Infections
Hepatitis B virus infection in hepatocellular carcinoma tissues upregulates expression of DNA methyltransferases.
Infections
Hepatitis B virus inhibits liver regeneration via epigenetic regulation of urokinase-type plasminogen activator.
Infections
Hepatitis B Virus X Protein Stimulates Virus Replication Via DNA Methylation of the C-1619 in Covalently Closed Circular DNA.
Infections
Hepatitis C virus represses E-cadherin expression via DNA methylation to induce epithelial to mesenchymal transition in human hepatocytes.
Infections
Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity.
Infections
Hypomethylation of host cell DNA synthesized after infection or transformation of cells by herpes simplex virus.
Infections
Identification of a Minimal 3-Transcript Signature to Differentiate Viral from Bacterial Infection from Best Genome-Wide Host RNA Biomarkers: A Multi-Cohort Analysis.
Infections
Increased cytomegalovirus replication by 5-Azacytidine and viral-induced cytoplasmic expression of DNMT?1 in medulloblastoma and endothelial cells.
Infections
Infection of lymphoid cells by integration-defective human immunodeficiency virus type 1 increases de novo methylation.
Infections
Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production.
Infections
Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression.
Infections
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Infections
Modulation of epigenetic factors during the early stages of HIV-1 infection in CD4+ T cells in vitro.
Infections
MOLECULAR MECHANISMS OF HSDS INVERSIONS IN THE COD LOCUS OF STREPTOCOCCUS PNEUMONIAE.
Infections
Polymorphisms of the DNA methyltransferase 1 associated with reduced risks of Helicobacter pylori infection and increased risks of gastric atrophy.
Infections
Putative association of DNA methyltransferase 1 (DNMT1) polymorphisms with clearance of HBV infection.
Infections
The de novo methyltransferases DNMT3a and DNMT3b target the murine gammaherpesvirus immediate-early gene 50 promoter during establishment of latency.
Infections
The DNA methyltransferase DNMT3A associates with viral proteins and impacts HSV-1 infection.
Infections
The phage growth limitation system in Streptomyces coelicolor A(3)2 is a toxin/antitoxin system, comprising enzymes with DNA methyltransferase, protein kinase and ATPase activity.
Infections
The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae.
Infections
Tissue-specific induced DNA methyltransferase 1 (Dnmt1) in endocrine pancreas by RCAS-TVA-based somatic gene transfer system promotes ?-cell proliferation.
Infections
Uropathogenic E. coli infection provokes epigenetic downregulation of CDKN2A (p16INK4A) in uroepithelial cells.
Infections
[Overexpression of DNA-methyltransferases in persistency of cccDNA pool in chronic hepatitis B].
Infertility
Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men.
Infertility, Male
Association between single-nucleotide polymorphisms of DNMT3L and infertility with azoospermia in Chinese men.
Infertility, Male
Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men.
Infertility, Male
Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis.
Infertility, Male
Idiopathic male infertility and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking.
Infertility, Male
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Inflammatory Bowel Diseases
Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity.
Influenza, Human
Epigenetic changes mediated by microRNA miR29 activate cyclooxygenase 2 and lambda-1 interferon production during viral infection.
Influenza, Human
Epigenetic modification is regulated by the interaction of influenza A virus nonstructural protein-1 with the de novo DNA methyltransferase DNMT3B and subsequent transport to the cytoplasm for K48-linked polyubiquitination.
Insulin Resistance
Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity.
Insulin Resistance
Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b.
Insulin Resistance
Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance.
Insulin Resistance
Interleukin-6 determines protein stabilization of DNA methyltransferases and alters DNA promoter methylation of genes associated with insulin signaling and angiogenesis.
Insulin Resistance
Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance.
Insulin Resistance
TET2 facilitates PPAR? agonist-mediated gene regulation and insulin sensitization in adipocytes.
Intellectual Disability
A Novel Single-Nucleotide Deletion (c.1020delA) in NSUN2 Causes Intellectual Disability in an Emirati Child.
Intellectual Disability
Acute myeloid leukaemia in a case with Tatton-Brown-Rahman syndrome: the peculiar DNMT3A R882 mutation.
Intellectual Disability
DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function.
Intellectual Disability
Expanding the phenotype of biallelic loss-of-function variants in the NSUN2 gene: Description of four individuals with juvenile cataract, chronic nephritis, or brain anomaly as novel complications.
Intellectual Disability
Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis.
Intellectual Disability
First identified Korean family with Tatton-Brown-Rahman Syndrome caused by the novel DNMT3A variant c.118G>C p.(Glu40Gln).
Intellectual Disability
Frequencies of Six (Five Novel) STR Markers Linked to TUSC3 (MRT7) or NSUN2 (MRT5) Genes Used for Homozygosity Mapping of Recessive Intellectual Disability.
Intellectual Disability
Further delineation of autosomal recessive intellectual disability syndrome caused by homozygous variant of the NSUN2 gene in a chinese pedigree.
Intellectual Disability
Identification of De Novo DNMT3A Mutations That Cause West Syndrome by Using Whole-Exome Sequencing.
Intellectual Disability
Mutation in NSUN2, which encodes an RNA methyltransferase, causes autosomal-recessive intellectual disability.
Intellectual Disability
Mutations in NSUN2 cause autosomal-recessive intellectual disability.
Intellectual Disability
Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability.
Intellectual Disability
Novel DNMT3A Germline Variant in a Patient with Multiple Paragangliomas and Papillary Thyroid Carcinoma.
Intellectual Disability
NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs.
Intellectual Disability
Tatton-Brown-Rahman syndrome with a novel DNMT3A mutation presented severe intellectual disability and autism spectrum disorder.
Intellectual Disability
The Tatton-Brown-Rahman Syndrome: A clinical study of 55 individuals with de novo constitutive DNMT3A variants.
Intervertebral Disc Degeneration
DNMT3B decreases extracellular matrix degradation and alleviates intervertebral disc degeneration through TRPA1 methylation to inhibit the COX2/YAP axis.
Intestinal Neoplasms
DNA hypomethylation contributes to genomic instability and intestinal cancer initiation.
Intestinal Neoplasms
DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation.
Ischemic Attack, Transient
Effects of Transient Cerebral Ischemia on the Expression of DNA Methyltransferase 1 in the Gerbil Hippocampal CA1 Region.
Keloid
Methylation of secreted frizzled-related protein 1 (SFRP1) promoter downregulates Wnt/?-catenin activity in keloids.
Keloid
The Expression of DNMT1 in Pathologic Scar Fibroblasts and the Effect of 5-aza-2-Deoxycytidine on Cytokines of Pathologic Scar Fibroblasts.
Kidney Diseases
Dnmt3a and Dnmt3b-Decommissioned Fetal Enhancers are Linked to Kidney Disease.
Kidney Failure, Chronic
Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1.
Kidney Neoplasms
Aberrant DNA methyltransferase 1 expression in clear cell renal cell carcinoma development and progression.
Klatskin Tumor
si-DNMT1 restore tumor suppressor genes expression through the reversal of DNA hypermethylation in cholangiocarcinoma.
Laryngeal Neoplasms
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in Laryngeal carcinoma.
Leiomyoma
5-aza-2'-deoxycitidine inhibits cell proliferation, extracellular matrix formation and Wnt/?-catenin pathway in human uterine leiomyomas.
Leiomyoma
Cross-talk between miR-29c and transforming growth factor-?3 is mediated by an epigenetic mechanism in leiomyoma.
Leiomyoma
DNA hypomethylation and imbalanced expression of DNA methyltransferases (DNMT1, 3A, and 3B) in human uterine leiomyoma.
Leiomyosarcoma
Temozolomide in advanced and recurrent uterine leiomyosarcoma and correlation with o6-methylguanine DNA methyltransferase expression: a case series.
Leiomyosarcoma
Treatment with epigenetic agents profoundly inhibits tumor growth in leiomyosarcoma.
Leukemia
8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1.
Leukemia
?-Arrestin1 promotes the self-renewal of the leukemia-initiating cell-enriched subpopulation in B-lineage acute lymphoblastic leukemia related to DNMT1 activity.
Leukemia
A Model System for Studying the DNMT3A Hotspot Mutation (DNMT3AR882) Demonstrates a Causal Relationship between Its Dominant-Negative Effect and Leukemogenesis.
Leukemia
Aberrant DNA methylation-induced gene inactivation is associated with the diagnosis and/or therapy of T-cell leukemias.
Leukemia
Abnormal promoter DNA methylation in juvenile myelomonocytic leukemia is not caused by mutation in DNMT3A.
Leukemia
Activation of HLA-G expression by 5-aza-2 - deoxycytidine in malignant hematopoetic cells isolated from leukemia patients.
Leukemia
Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine.
Leukemia
Acute Myeloid Leukemia With Recurrent Genetic Abnormalities Other Than Translocations.
Leukemia
Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice.
Leukemia
Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation.
Leukemia
Chronic myelomonocytic leukemia with double-mutations in DNMT3A and FLT3-ITD treated with decitabine and sorafenib.
Leukemia
Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1.
Leukemia
Codelivery of Genistein and miRNA-29b to A549 Cells Using Aptamer-Hybrid Nanoparticle Bioconjugates.
Leukemia
Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells.
Leukemia
Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2'-deoxycytidine in human leukemic KG1 cells.
Leukemia
De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation.
Leukemia
Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation.
Leukemia
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
Leukemia
Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation.
Leukemia
Development and validation of a gas chromatography/mass spectrometry method for the assessment of genomic DNA methylation.
Leukemia
Differentiation therapy in poor risk myeloid malignancies: Results of a dose finding study of the combination bryostatin-1 and GM-CSF.
Leukemia
DNA damage response as a prognostic indicator in metastatic breast cancer via mutational analysis.
Leukemia
DNA methyl transferase I acts as a negative regulator of allergic skin inflammation.
Leukemia
DNA methylation changes in hematologic malignancies: biologic and clinical implications.
Leukemia
DNA methyltransferase 1-mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1-driven leukemogenesis.
Leukemia
DNA methyltransferase inhibition induces mouse embryonic stem cell differentiation into endothelial cells.
Leukemia
DNA methyltransferase inhibitor RG108 and histone deacetylase inhibitors cooperate to enhance NB4 cell differentiation and E-cadherin re-expression by chromatin remodeling.
Leukemia
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Leukemia
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells.
Leukemia
DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells.
Leukemia
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.
Leukemia
DNMT3A mutation is a poor prognosis biomarker in AML: Results of a meta-analysis of 4500 AML patients.
Leukemia
DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms.
Leukemia
DNMT3A mutations are associated with inferior overall and leukemia-free survival in chronic myelomonocytic leukemia.
Leukemia
DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia.
Leukemia
Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.
Leukemia
Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience.
Leukemia
DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.
Leukemia
Downregulation of miR-217 correlates with resistance of ph(+) leukemia cells to ABL tyrosine kinase inhibitors.
Leukemia
Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic syndrome.
Leukemia
Early T-cell precursor acute lymphoblastic leukemia with KRAS and DNMT3A mutations and unexpected monosomy 7.
Leukemia
Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup.
Leukemia
Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.
Leukemia
Epigenetic regulation of the human telomerase reverse transciptase gene: A potential therapeutic target for the treatment of leukemia (Review).
Leukemia
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.
Leukemia
Exosomal DNMT1 mRNA transcript is elevated in acute lymphoblastic leukemia which might reprograms leukemia progression.
Leukemia
Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia.
Leukemia
Haemophagocytic lymphohistiocytosis occurred during induction chemotherapy in an acute monocytic leukemia patient with FLT3-ITD and DNMT3A mutations.
Leukemia
Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.
Leukemia
Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.
Leukemia
Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation.
Leukemia
IDH1/2 but not DNMT3A mutations are suitable targets for minimal residual disease monitoring in acute myeloid leukemia patients: a study by the Acute Leukemia French Association.
Leukemia
Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins.
Leukemia
Influence of Histone Deacetylase Inhibitors and DNA-Methyltransferase Inhibitors on the NK Cell-Mediated Lysis of Pediatric B-Lineage Leukemia.
Leukemia
Inhibition of DNA methylation in L1210 leukemic cells by 5-aza-2'-deoxycytidine as a possible mechanism of chemotherapeutic action.
Leukemia
Leukemia cutis with IDH1, DNMT3A and NRAS mutations conferring resistance to venetoclax plus 5-azacytidine in refractory AML.
Leukemia
Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-?c-/- mice.
Leukemia
Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy.
Leukemia
Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-?.
Leukemia
Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.
Leukemia
miR-126 promotes the growth and proliferation of leukemia stem cells by targeting DNA methyltransferase 1.
Leukemia
miR-9 plays a role in IL-10-mediated expression of E-cadherin in acute myelogenous leukemia cells.
Leukemia
Mitoxantrone, etoposide and cytarabine following epigenetic priming with decitabine in adults with relapsed/refractory acute myeloid leukemia or other high-grade myeloid neoplasms: a phase 1/2 study.
Leukemia
Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes.
Leukemia
Multicolor Flow Cytometry and Multi-Gene Next Generation Sequencing are Complementary and Highly Predictive for Relapse in Acute Myeloid Leukemia Following Allogeneic Transplant.
Leukemia
Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation and relapse.
Leukemia
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2 and DNMT3A.
Leukemia
Mutations in DNMT3A and loss of RKIP are independent events in acute monocytic leukemia.
Leukemia
Novel Mutations in a Lethal Case of Lymphomatous Adult T Cell Lymphoma with Cryptic Myocardial Involvement.
Leukemia
Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia.
Leukemia
Overexpression of microRNA-143 inhibits growth and induces apoptosis in human leukemia cells.
Leukemia
Palliative chemotherapy followed by methylation inhibitor in high-risk acute myeloid leukemia: An in vitro and clinical study.
Leukemia
Panobinostat treatment depletes EZH2 and DNMT1 levels and enhances decitabine mediated de-repression of JunB and loss of survival of human acute leukemia cells.
Leukemia
Perinatal Programming of Adult Rat Germ Cell Death After Exposure to Xenoestrogens: Role of microRNA miR-29 Family in the Down-Regulation of DNA Methyltransferases and Mcl-1.
Leukemia
PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation.
Leukemia
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
Leukemia
Progesterone receptor gene inactivation and CpG island hypermethylation in human leukemia cancer cells.
Leukemia
Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association.
Leukemia
Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a.
Leukemia
Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors: basic concepts and clinical applications.
Leukemia
Regulation of DNA methylation and tumor suppression gene expression by miR-29b in leukemia patients and related mechanisms.
Leukemia
Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo.
Leukemia
Runx1 Regulation of Pu.1 Corepressor/Coactivator Exchange Identifies Specific Molecular Targets for Leukemia Differentiation Therapy.
Leukemia
Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia.
Leukemia
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors.
Leukemia
The Gene Expression Profile and DNA Methylation Pattern of CDH1 and DNMT1 Genes in Acute Promyelocytic Leukemia (APL).
Leukemia
The role of human equilibrative nucleoside transporter 1 on the cellular transport of the DNA methyltransferase inhibitors 5-azacytidine and CP-4200 in human leukemia cells.
Leukemia
Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells.
Leukemia
Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.
Leukemia
Tocotrienol-rich fraction from annatto ameliorates expression of lysyl oxidase in human osteoblastic MG-63 cells.
Leukemia
Total synthesis of the proposed structures of the DNA methyl transferase inhibitors peyssonenynes, and structural revision of peyssonenyne B.
Leukemia
Two Novel Methods for Rapid Detection and Quantification of DNMT3A R882 Mutations in Acute Myeloid Leukemia.
Leukemia
Xiao W, Bharadwaj M, Levine M, et al. PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation. Blood Adv. 2018;2(23):3526-3539.
Leukemia
YTHDF2 is a potential target of AML1/ETO-HIF1? loop-mediated cell proliferation in t(8;21) AML.
Leukemia
ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma.
Leukemia
[Clinical significance of the expression of DNA methyltransferase genes (DNMT) in acute leukemia patients.]
Leukemia
[Prognostic Value of Recurrent Molecular Genetics and Epigenetics Abnormity in T Lymphoblastic Lymphoma / Leukemia -Review].
Leukemia
[The C46359T polymorphism of DNMT3B promoter gene and pathogenesis of acute leukemia]
Leukemia
[The expression of DNA methyltransferase DNMT1, 3A and 3B in acute leukemia and myelodysplastic syndrome]
Leukemia
[The re-expression of p15(INK4B) gene in leukemia cells induced by in vitro DNA methyltransferase and histone deacetylase inhibition]
Leukemia, Biphenotypic, Acute
Gene expression profiling of the DNMT3A R882 mutation in acute leukemia.
Leukemia, Erythroblastic, Acute
A potent cell-active allosteric inhibitor of murine DNA cytosine C5 methyltransferase.
Leukemia, Erythroblastic, Acute
Effect of aphidicolin on DNA methyltransferase in the nucleus.
Leukemia, Erythroblastic, Acute
Growth-dependent expression of multiple species of DNA methyltransferase in murine erythroleukemia cells.
Leukemia, Erythroblastic, Acute
In vitro methylation of the 5'-flanking regions of the mouse beta-globin gene.
Leukemia, Erythroblastic, Acute
Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine.
Leukemia, Erythroblastic, Acute
Interaction of DNA methyltransferase and other non-histone proteins isolated from Friend erythroleukemia cell nuclei with 5-azacytosine residues in DNA.
Leukemia, Erythroblastic, Acute
Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Localization of DNA methyltransferase in the chromatin of Friend erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Naturally occurring methylation inhibitor: DNA hypomethylation and hemoglobin synthesis in human K562 cells.
Leukemia, Erythroblastic, Acute
Peptide mapping of the murine DNA methyltransferase reveals a major phosphorylation site and the start of translation.
Leukemia, Erythroblastic, Acute
Purification and stabilization of mouse DNA methyltransferase.
Leukemia, Erythroblastic, Acute
Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.
Leukemia, Hairy Cell
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
Leukemia, Large Granular Lymphocytic
Concurrent STAT3, DNMT3A, and TET2 mutations in T-LGL leukemia with molecularly distinct clonal hematopoiesis of indeterminate potential.
Leukemia, Lymphocytic, Chronic, B-Cell
Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma.
Leukemia, Lymphocytic, Chronic, B-Cell
Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice.
Leukemia, Lymphocytic, Chronic, B-Cell
Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a.
Leukemia, Monocytic, Acute
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.
Leukemia, Monocytic, Acute
Haemophagocytic lymphohistiocytosis occurred during induction chemotherapy in an acute monocytic leukemia patient with FLT3-ITD and DNMT3A mutations.
Leukemia, Monocytic, Acute
Mutations in DNMT3A and loss of RKIP are independent events in acute monocytic leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
A carrier-mediated prodrug approach to improve the oral absorption of antileukemic drug decitabine.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Absence of DNMT3A gene mutation in chronic myeloid leukemia patients in blast crisis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Depleting long noncoding RNA HOTAIR attenuates chronic myelocytic leukemia progression by binding to DNA methyltransferase 1 and inhibiting PTEN gene promoter methylation.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
DNA Methyltransferase 1 Drives Transcriptional Down-Modulation of ? Catenin Antagonist Chibby1 Associated With the BCR-ABL1 Gene of Chronic Myeloid Leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
DNA methyltransferase 1 mediated aberrant methylation and silencing of SHP-1 gene in chronic myelogenous leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Effects of DNA Methylation on Leukemia Cell Proliferation.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Exome sequencing reveals DNMT3A and ASXL1 variants associate with progression of chronic myeloid leukemia after tyrosine kinase inhibitor therapy.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins.
Leukemia, Myeloid
5-Aza-2'-Deoxycytidine and DNA Methyltransferase Inhibitors in the Treatment of Myeloid Leukemias and Myelodysplastic Syndromes: Biological Aspects and Clinical Results. Proceedings of a workshop. Rome, Italy, November 3, 1991.
Leukemia, Myeloid
A Novel t(8;14)(q24;q11) Rearranged Human Cell Line as a Model for Mechanistic and Drug Discovery Studies of NOTCH1-Independent Human T-Cell Leukemia.
Leukemia, Myeloid
Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1.
Leukemia, Myeloid
Dnmt1 links BCR-ABLp210 to epigenetic tumor stem cell priming in myeloid leukemia.
Leukemia, Myeloid
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.
Leukemia, Myeloid
Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation.
Leukemia, Myeloid
Quantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells.
Leukemia, Myeloid, Acute
5-Aza-4'-thio-2'-deoxycytidine, a new orally bioavailable non-toxic "best-in-class" DNMT1 depleting agent in clinical development.
Leukemia, Myeloid, Acute
A case of familial transmission of the newly described DNMT3A-Overgrowth Syndrome.
Leukemia, Myeloid, Acute
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells.
Leukemia, Myeloid, Acute
A mutational and expressional analysis of DNMT3A in acute myeloid leukemia cytogenetic subgroups.
Leukemia, Myeloid, Acute
A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia.
Leukemia, Myeloid, Acute
A vicious loop of fatty acid-binding protein 4 and DNA methyltransferase 1 promotes acute myeloid leukemia and acts as a therapeutic target.
Leukemia, Myeloid, Acute
Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing.
Leukemia, Myeloid, Acute
Acute myeloid leukemia cells exhibit selective down-regulation of DNMT3A isoform 2.
Leukemia, Myeloid, Acute
Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis.
Leukemia, Myeloid, Acute
Acute Myeloid Leukemia with Del(9q) is Characterized by Frequent Mutations of NPM1, DNMT3A, WT1 and Low Expression of TLE4.
Leukemia, Myeloid, Acute
Acute myeloid leukemia-associated DNMT3A p.Arg882His mutation in a patient with Tatton-Brown-Rahman overgrowth syndrome as a constitutional mutation.
Leukemia, Myeloid, Acute
Adult acute myeloid leukemia with trisomy 11 as the sole abnormality is characterized by the presence of five distinct gene mutations: MLL-PTD, DNMT3A, U2AF1, FLT3-ITD and IDH2.
Leukemia, Myeloid, Acute
Age-Related Prognostic Impact of Different Types of DNMT3A Mutations in Adults With Primary Cytogenetically Normal Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Allogeneic hematopoietic stem cell transplantation could improve survival of cytogenetically normal adult acute myeloid leukemia patients with DNMT3A mutations.
Leukemia, Myeloid, Acute
An miRNA-DNMT1 Axis Is Involved in Azacitidine Resistance and Predicts Survival in Higher-Risk Myelodysplastic Syndrome and Low Blast Count Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Association between DNMT3A mutations and prognosis of adults with de novo acute myeloid leukemia: a systematic review and meta-analysis.
Leukemia, Myeloid, Acute
Association between increased mutation rates in DNMT3A and FLT3-ITD and poor prognosis of patients with acute myeloid leukemia.
Leukemia, Myeloid, Acute
Bioinformatics Analysis Identifies Key Genes and Pathways in Acute Myeloid Leukemia Associated with DNMT3A Mutation.
Leukemia, Myeloid, Acute
Biological and clinical influences of NPM1 in acute myeloid leukemia patients with DNMT3A mutations.
Leukemia, Myeloid, Acute
Biologico-clinical significance of DNMT3A variants expression in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Case Report: Refusal of an Veno-Arterial Extracorporeal Membrane Oxygenation Due to Malignant Disease? - An Extremely Rare Form of Cardiac Involvement in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML.
Leukemia, Myeloid, Acute
Characterization of DNA demethylation effects induced by 5-Aza-2'-deoxycytidine in patients with myelodysplastic syndrome.
Leukemia, Myeloid, Acute
Clinical and biological implications of IDH1/2 in acute myeloid leukemia with DNMT3Amut.
Leukemia, Myeloid, Acute
Clinical Effect of Combined Mutations in DNMT3A, FLT3-ITD, and NPM1 Among Egyptian Acute Myeloid Leukemia Patients.
Leukemia, Myeloid, Acute
Clinical Features and MicroRNA Expression Patterns Between AML Patients With DNMT3A R882 and Frameshift Mutations.
Leukemia, Myeloid, Acute
Clinical features of de novo acute myeloid leukemia with concurrent DNMT3A, FLT3 and NPM1 mutations.
Leukemia, Myeloid, Acute
Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG).
Leukemia, Myeloid, Acute
Co-occurrence of DNMT3A, NPM1, FLT3 mutations identifies a subset of acute myeloid leukemia with adverse prognosis.
Leukemia, Myeloid, Acute
Comparative examination of various PCR-based methods for DNMT3A and IDH1/2 mutations identification in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Comparison of high-resolution melting analysis with direct sequencing for the detection of recurrent mutations in DNA methyltransferase 3A and isocitrate dehydrogenase 1 and 2 genes in acute myeloid leukemia patients.
Leukemia, Myeloid, Acute
Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells.
Leukemia, Myeloid, Acute
Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement.
Leukemia, Myeloid, Acute
Continuation of a Levonorgestrel Intrauterine Device During Hematopoietic Stem Cell Transplant: A Case Report.
Leukemia, Myeloid, Acute
Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2 and DNMT3A.
Leukemia, Myeloid, Acute
Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.
Leukemia, Myeloid, Acute
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Leukemia, Myeloid, Acute
Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Decitabine Downregulates TIGAR to Induce Apoptosis and Autophagy in Myeloid Leukemia Cells.
Leukemia, Myeloid, Acute
Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation.
Leukemia, Myeloid, Acute
Depletion of ZBTB38 potentiates the effects of DNA demethylating agents in cancer cells via CDKN1C mRNA up-regulation.
Leukemia, Myeloid, Acute
Detection of high-frequency and novel DNMT3A mutations in acute myeloid leukemia by high-resolution melting curve analysis.
Leukemia, Myeloid, Acute
DNA methylation and hydroxymethylation patterns in acute myeloid leukemia patients with mutations in DNMT3A and IDH1/2 and their combinations.
Leukemia, Myeloid, Acute
DNA methyltransferase inhibitors in acute myeloid leukemia: Discovery, design and first therapeutic experiences.
Leukemia, Myeloid, Acute
DNMT3A (R882) mutation features and prognostic effect in acute myeloid leukemia in Coexistent with NPM1 and FLT3 mutations.
Leukemia, Myeloid, Acute
DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies.
Leukemia, Myeloid, Acute
DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells.
Leukemia, Myeloid, Acute
Dnmt3a haploinsufficiency transforms Flt3-ITD myeloproliferative disease into a rapid, spontaneous, and fully-penetrant acute myeloid leukemia.
Leukemia, Myeloid, Acute
DNMT3A intragenic hypomethylation is associated with adverse prognosis in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis.
Leukemia, Myeloid, Acute
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
Leukemia, Myeloid, Acute
DNMT3A mutant transcript levels persist in remission and do not predict outcome in patients with acute myeloid leukemia.
Leukemia, Myeloid, Acute
DNMT3A mutation leads to leukemic extramedullary infiltration mediated by TWIST1.
Leukemia, Myeloid, Acute
DNMT3A Mutation-Induced CDK1 Overexpression Promotes Leukemogenesis by Modulating the Interaction between EZH2 and DNMT3A.
Leukemia, Myeloid, Acute
DNMT3A Mutational Status Affects the Results of Dose-Escalated Induction Therapy in Acute Myelogenous Leukemia.
Leukemia, Myeloid, Acute
DNMT3A mutations and clinical features in Chinese patients with acute myeloid leukemia.
Leukemia, Myeloid, Acute
DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia.
Leukemia, Myeloid, Acute
DNMT3A mutations at R882 hotspot are only found in major clones of acute myeloid leukemia.
Leukemia, Myeloid, Acute
DNMT3A mutations in acute myeloid leukemia: impact on low-risk patients with CEBPA mutations.
Leukemia, Myeloid, Acute
DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications.
Leukemia, Myeloid, Acute
DNMT3a mutations in high-risk myelodysplastic syndrome parallel those found in acute myeloid leukemia.
Leukemia, Myeloid, Acute
DNMT3A Mutations in Patients with Acute Myeloid Leukemia in South Brazil.
Leukemia, Myeloid, Acute
DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia.
Leukemia, Myeloid, Acute
DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling.
Leukemia, Myeloid, Acute
DNMT3A R882 mutation is associated with elevated expression of MAFB and M4/M5 immunophenotype of acute myeloid leukemia blasts.
Leukemia, Myeloid, Acute
DNMT3A R882 Mutation with FLT3-ITD Positivity Is an Extremely Poor Prognostic Factor in Patients with Normal-Karyotype Acute Myeloid Leukemia after Allogeneic Hematopoietic Cell Transplantation.
Leukemia, Myeloid, Acute
DNMT3A R882 mutations in patients with cytogenetically normal acute myeloid leukemia and myelodysplastic syndrome.
Leukemia, Myeloid, Acute
Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.
Leukemia, Myeloid, Acute
DNMT3A, TET2, and JAK2 mutations in polycythemia vera following long-term remission of secondary acute myeloid leukemia.
Leukemia, Myeloid, Acute
Dnmt3b Methylates DNA by a Noncooperative Mechanism, and Its Activity Is Unaffected by Manipulations at the Predicted Dimer Interface.
Leukemia, Myeloid, Acute
Do age-associated DNA methylation changes increase the risk of malignant transformation?
Leukemia, Myeloid, Acute
Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience.
Leukemia, Myeloid, Acute
Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis.
Leukemia, Myeloid, Acute
DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.
Leukemia, Myeloid, Acute
Droplet digital polymerase chain reaction for DNMT3A and IDH1/2 mutations to improve early detection of acute myeloid leukemia relapse after allogeneic hematopoietic stem cell transplantation.
Leukemia, Myeloid, Acute
Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic syndrome.
Leukemia, Myeloid, Acute
Effect of DNMT3A variant allele frequency and double mutation on clinicopathologic features of patients with de novo AML.
Leukemia, Myeloid, Acute
Epigenetic landscape analysis of lncRNAs in acute myeloid leukemia with DNMT3A mutations.
Leukemia, Myeloid, Acute
Epigenetic modifiers: basic understanding and clinical development.
Leukemia, Myeloid, Acute
Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Evaluation of DNMT3A genetic polymorphisms as outcome predictors in AML patients.
Leukemia, Myeloid, Acute
Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia.
Leukemia, Myeloid, Acute
Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B.
Leukemia, Myeloid, Acute
Expression Profiles of DNA Methylation and Demethylation Machinery Components in Pediatric Myelodysplastic Syndrome: Clinical Implications.
Leukemia, Myeloid, Acute
FLT3-ITD Compared with DNMT3A R882 Mutation Is a More Powerful Independent Inferior Prognostic Factor in Adult Acute Myeloid Leukemia Patients After Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Cohort Study
Leukemia, Myeloid, Acute
FLT3-ITD with DNMT3A R882 double mutation is a poor prognostic factor in Chinese patients with acute myeloid leukemia after chemotherapy or allogeneic hematopoietic stem cell transplantation.
Leukemia, Myeloid, Acute
FLT3-ITD, NPM1, and DNMT3A Gene Mutations and Risk Factors in Normal Karyotype Acute Myeloid Leukemia and Myelodysplastic Syndrome Patients in Upper Northern Thailand
Leukemia, Myeloid, Acute
Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia.
Leukemia, Myeloid, Acute
Functional Analysis of DNMT3A DNA Methyltransferase Mutations Reported in Patients with Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.
Leukemia, Myeloid, Acute
Further delineation of neuropsychiatric findings in Tatton-Brown-Rahman syndrome due to disease-causing variants in DNMT3A: seven new patients.
Leukemia, Myeloid, Acute
GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations.
Leukemia, Myeloid, Acute
Gene expression profiling of the DNMT3A R882 mutation in acute leukemia.
Leukemia, Myeloid, Acute
Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia.
Leukemia, Myeloid, Acute
Genetic and Epigenetic Perturbations by DNMT3A-R882 Mutants Impaired Apoptosis through Augmentation of PRDX2 in Myeloid Leukemia Cells.
Leukemia, Myeloid, Acute
Genomic and epigenomic predictors of response to guadecitabine in relapsed/refractory acute myelogenous leukemia.
Leukemia, Myeloid, Acute
Genomic markers of midostaurin drug sensitivity in FLT3 mutated and FLT3 wild-type acute myeloid leukemia patients.
Leukemia, Myeloid, Acute
Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.
Leukemia, Myeloid, Acute
Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.
Leukemia, Myeloid, Acute
High DNA methyltransferase DNMT3B levels: a poor prognostic marker in acute myeloid leukemia.
Leukemia, Myeloid, Acute
High DNA-methyltransferase 3B expression predicts poor outcome in acute myeloid leukemia, especially among patients with co-occurring NPM1 and FLT3 mutations.
Leukemia, Myeloid, Acute
High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis.
Leukemia, Myeloid, Acute
HOTAIR suppresses PTEN via DNMT3b and confers drug resistance in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Hypomethylating Agents in the Treatment of Myelodysplastic Syndromes and Myeloid Leukemia.
Leukemia, Myeloid, Acute
Identification of Two DNMT3A Mutations Compromising Protein Stability and Methylation Capacity in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
IDH1/2 but not DNMT3A mutations are suitable targets for minimal residual disease monitoring in acute myeloid leukemia patients: a study by the Acute Leukemia French Association.
Leukemia, Myeloid, Acute
Impact of the variant allele frequency of ASXL1, DNMT3A, JAK2, TET2, TP53, and NPM1 on the outcomes of patients with newly diagnosed acute myeloid leukemia.
Leukemia, Myeloid, Acute
Incidence and Prognostic Impact of DNMT3A Mutations in Korean Normal Karyotype Acute Myeloid Leukemia Patients.
Leukemia, Myeloid, Acute
Incidence and Prognostic Influence of DNMT3A Mutations in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.
Leukemia, Myeloid, Acute
Influence of DNMT3A R882 mutations on AML prognosis determined by the allele ratio in Chinese patients.
Leukemia, Myeloid, Acute
Inhibition of DNA methyltransferase activates tumor necrosis factor alpha-induced monocytic differentiation in acute myeloid leukemia cells.
Leukemia, Myeloid, Acute
Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS.
Leukemia, Myeloid, Acute
Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Investigation of screening method for DNMT3A mutations by high-resolution melting analysis in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Lack of association of IDH1, IDH2 and DNMT3A mutations with outcome in older patients with acute myeloid leukemia treated with hypomethylating agents.
Leukemia, Myeloid, Acute
Landscape of Tumor Suppressor Mutations in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: a report from the Children's Oncology Group.
Leukemia, Myeloid, Acute
Low frequency of mutations in Chinese with acute myeloid leukemia: Different disease or different aetiology?
Leukemia, Myeloid, Acute
Low-Dose Azacitidine with DNMT1 Level Monitoring to Treat Post-Transplantation Acute Myelogenous Leukemia or Myelodysplastic Syndrome Relapse.
Leukemia, Myeloid, Acute
MicroRNA -29b induces global DNA hypomethylation and tumor suppressor gene re-expression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.
Leukemia, Myeloid, Acute
Molecular Evaluation of DNMT3A and IDH1/2 Gene Mutation: Frequency, Distribution Pattern and Associations with Additional Molecular Markers in Normal Karyotype Indian Acute Myeloid Leukemia Patients.
Leukemia, Myeloid, Acute
MUC1-C induces DNA methyltransferase 1 and represses tumor suppressor genes in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Mutant DNMT3A clone evading chemotherapy and infiltrating central nervous system in a patient with molecularly good-risk acute myeloid leukemia.
Leukemia, Myeloid, Acute
Mutant DNMT3A in acute myeloid leukemia: guilty of inducing genetic instability?
Leukemia, Myeloid, Acute
Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Mutation Analysis of Isocitrate Dehydrogenase (IDH1/2) and DNA Methyltransferase 3A (DNMT3A) in Thai Patients with Newly Diagnosed Acute Myeloid Leukemia
Leukemia, Myeloid, Acute
Mutation profiling of 19 candidate genes in acute myeloid leukemia suggests significance of DNMT3A mutations.
Leukemia, Myeloid, Acute
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Leukemia, Myeloid, Acute
Mutations in DNA Methyltransferase (DNMT3A) Observed in Acute Myeloid Leukemia Patients Disrupt Processive Methylation.
Leukemia, Myeloid, Acute
Mutations in DNMT3A and loss of RKIP are independent events in acute monocytic leukemia.
Leukemia, Myeloid, Acute
Mutations in DNMT3A, U2AF1, and EZH2 identify intermediate-risk acute myeloid leukemia patients with poor outcome after CR1.
Leukemia, Myeloid, Acute
Mutations in TET2 and DNMT3A genes are associated with changes in global and gene-specific methylation in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability.
Leukemia, Myeloid, Acute
Mutations in the DNMT3A DNA methyltransferase in AML patients cause both loss and gain of function and differential regulation by protein partners.
Leukemia, Myeloid, Acute
Mutations in the DNMT3A exon 23 independently predict poor outcome in older patients with acute myeloid leukemia: a SWOG report.
Leukemia, Myeloid, Acute
Next-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutations.
Leukemia, Myeloid, Acute
Next-generation sequencing-based multigene mutational screening for acute myeloid leukemia using MiSeq: applicability for diagnostics and disease monitoring.
Leukemia, Myeloid, Acute
Noncanonical immune response to the inhibition of DNA methylation by Staufen1 via stabilization of endogenous retrovirus RNAs.
Leukemia, Myeloid, Acute
Novel approaches for myelodysplastic syndromes: beyond hypomethylating agents.
Leukemia, Myeloid, Acute
Novel DNMT3A Germline Variant in a Patient with Multiple Paragangliomas and Papillary Thyroid Carcinoma.
Leukemia, Myeloid, Acute
Novel impact of the DNMT3A R882H mutation on GSH metabolism in a K562 cell model established by TALENs.
Leukemia, Myeloid, Acute
On the potential role of DNMT1 in acute myeloid leukemia and myelodysplastic syndromes: not another mutated epigenetic driver.
Leukemia, Myeloid, Acute
Opposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms.
Leukemia, Myeloid, Acute
Oral Azacitidine and Cedazuridine Approximate Parenteral Azacitidine Efficacy in Murine Model.
Leukemia, Myeloid, Acute
p53 and TDG are dominant in regulating the activity of the human de novo DNA methyltransferase DNMT3A on nucleosomes.
Leukemia, Myeloid, Acute
Persistent DNMT3A mutation burden in DNMT3A mutated adult cytogenetically normal acute myeloid leukemia patients in long-term remission.
Leukemia, Myeloid, Acute
Pharmacokinetic evaluation of decitabine for the treatment of leukemia.
Leukemia, Myeloid, Acute
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
Leukemia, Myeloid, Acute
Preliminary study on the role of miR?148a and DNMT1 in the pathogenesis of acute myeloid leukemia.
Leukemia, Myeloid, Acute
Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia.
Leukemia, Myeloid, Acute
Prognostic Impact of Concurrent DNMT3A, FLT3 and NPM1 Gene Mutations in Acute Myeloid Leukemia Patients.
Leukemia, Myeloid, Acute
Prognostic impact of DNMT3A mutation in acute myeloid leukemia with mutated NPM1.
Leukemia, Myeloid, Acute
Prognostic impact of DNMT3A mutations in patients with intermediate cytogenetic risk profile acute myeloid leukemia.
Leukemia, Myeloid, Acute
Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association.
Leukemia, Myeloid, Acute
Prognostic significance of DNMT3A mutations in patients with acute myeloid leukemia.
Leukemia, Myeloid, Acute
Proteomic analysis identifies differentially expressed proteins in AML1/ETO acute myeloid leukemia cells treated with DNMT inhibitors azacitidine and decitabine.
Leukemia, Myeloid, Acute
Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Rapid detection of DNMT3A R882 codon mutations allows early identification of poor risk patients with acute myeloid leukemia.
Leukemia, Myeloid, Acute
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes.
Leukemia, Myeloid, Acute
Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.
Leukemia, Myeloid, Acute
Remethylation of Dnmt3a-/- hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing.
Leukemia, Myeloid, Acute
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Leukemia, Myeloid, Acute
Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Screening for mutation R882 in the DNMT3A gene in Chinese patients with hematological disease.
Leukemia, Myeloid, Acute
SHP2 inhibition reduces leukemogenesis in models of combined genetic and epigenetic mutations.
Leukemia, Myeloid, Acute
Silencing long non-coding RNA HOTAIR exerts anti-oncogenic effect on human acute myeloid leukemia via demethylation of HOXA5 by inhibiting Dnmt3b.
Leukemia, Myeloid, Acute
Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects.
Leukemia, Myeloid, Acute
Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Simultaneous inhibition of DNA methyltransferase and histone deacetylase induces p53-independent apoptosis via down-regulation of Mcl-1 in acute myelogenous leukemia cells.
Leukemia, Myeloid, Acute
Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.
Leukemia, Myeloid, Acute
Study on the Immune Escape Mechanism of Acute Myeloid Leukemia With DNMT3A Mutation.
Leukemia, Myeloid, Acute
Synergistic inhibitory effects of low-dose decitabine in combination with bortezomib in the AML cell line Kasumi-1.
Leukemia, Myeloid, Acute
Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL).
Leukemia, Myeloid, Acute
The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme.
Leukemia, Myeloid, Acute
The combination of FLT3 and DNA methyltransferase inhibition is synergistically cytotoxic to FLT3/ITD acute myeloid leukemia cells.
Leukemia, Myeloid, Acute
The DNA demethylating agent decitabine activates the TRAIL pathway and induces apoptosis in acute myeloid leukemia.
Leukemia, Myeloid, Acute
The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression.
Leukemia, Myeloid, Acute
The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells.
Leukemia, Myeloid, Acute
The DNMT3A R882H mutant displays altered flanking sequence preferences.
Leukemia, Myeloid, Acute
The influence of DNMT3A and DNMT3B gene polymorphisms on acute myeloid leukemia risk in a Moroccan population.
Leukemia, Myeloid, Acute
The prevalence and clinical profiles of FLT3-ITD, FLT3-TKD, NPM1, C-KIT, DNMT3A, and CEBPA mutations in a cohort of patients with de novo acute myeloid leukemia from southwest China.
Leukemia, Myeloid, Acute
The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers.
Leukemia, Myeloid, Acute
The R882H substitution in the human de novo DNA methyltransferase DNMT3A disrupts allosteric regulation by the tumor supressor p53.
Leukemia, Myeloid, Acute
The role of autophagy in targeted therapy for acute myeloid leukemia.
Leukemia, Myeloid, Acute
The spectrum of DNMT3A variants in Tatton-Brown-Rahman syndrome overlaps with that in hematologic malignancies.
Leukemia, Myeloid, Acute
Two Novel Methods for Rapid Detection and Quantification of DNMT3A R882 Mutations in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoiesis.
Leukemia, Myeloid, Acute
[Analysis of prognosis of acute myeloid leukemia patients based on genetic mutations].
Leukemia, Myeloid, Acute
[Detection of DNMT3a mutation in acute myelogenous leukemia and its clinical significance].
Leukemia, Myeloid, Acute
[Effect of FLT3-ITD with DNMT3A R882 double-mutation on the prognosis of acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation].
Leukemia, Myeloid, Acute
[Effects of DNMT3A gene mutations on prognosis of patients with acute myeloid leukemia: a meta-analysis].
Leukemia, Myeloid, Acute
[Expression of DNMT gene in bone marrow of patients with acute myelogenous leukemia and its significance].
Leukemia, Myeloid, Acute
[Identification of novel pathogenic gene mutations in pediatric acute myeloid leukemia by whole-exome resequencing].
Leukemia, Myeloid, Acute
[Outcomes of refractory or relapsed DNMT3A + cytogenetically normal acute myeloid leukemia patients followed the therapy including decitabine combined with CAG or CAG-like regimen].
Leukemia, Myeloid, Acute
[The clinical characteristics and prognoses of de novo acute myeloid leukemia patients with DNA methyltransferase 3A gene mutations].
Leukemia, Myelomonocytic, Chronic
Acute Myeloid Leukemia With Recurrent Genetic Abnormalities Other Than Translocations.
Leukemia, Myelomonocytic, Chronic
Chronic myelomonocytic leukemia with double-mutations in DNMT3A and FLT3-ITD treated with decitabine and sorafenib.
Leukemia, Myelomonocytic, Chronic
DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells.
Leukemia, Myelomonocytic, Chronic
DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms.
Leukemia, Myelomonocytic, Chronic
DNMT3A mutations are associated with inferior overall and leukemia-free survival in chronic myelomonocytic leukemia.
Leukemia, Myelomonocytic, Chronic
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2 and DNMT3A.
Leukemia, Myelomonocytic, Chronic
Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia.
Leukemia, Myelomonocytic, Chronic
Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia.
Leukemia, Myelomonocytic, Juvenile
Abnormal promoter DNA methylation in juvenile myelomonocytic leukemia is not caused by mutation in DNMT3A.
Leukemia, Myelomonocytic, Juvenile
Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-?c-/- mice.
Leukemia, Myelomonocytic, Juvenile
Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia.
Leukemia, Plasma Cell
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Leukemia, Promyelocytic, Acute
Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation.
Leukemia, Promyelocytic, Acute
Differentiation therapy in poor risk myeloid malignancies: Results of a dose finding study of the combination bryostatin-1 and GM-CSF.
Leukemia, Promyelocytic, Acute
Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience.
Leukemia, Promyelocytic, Acute
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo.
Leukemia, Promyelocytic, Acute
The Gene Expression Profile and DNA Methylation Pattern of CDH1 and DNMT1 Genes in Acute Promyelocytic Leukemia (APL).
Leukemia, Promyelocytic, Acute
The role of autophagy in targeted therapy for acute myeloid leukemia.
Leukemia, T-Cell
Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup.
Leukemia-Lymphoma, Adult T-Cell
North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies.
Leukocytosis
Effect of DNMT3A variant allele frequency and double mutation on clinicopathologic features of patients with de novo AML.
Leukoplakia
Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas.
Leukoplakia, Oral
Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas.
Li-Fraumeni Syndrome
Epigenetic and functional analysis of IGFBP3 and IGFBPrP1 in cellular immortalization.
Lichen Planus, Oral
DNMT3B (C46359T) polymorphisms and immunoexpression of DNMT3b and DNMT1 proteins in oral lichen planus.
Liposarcoma
miR-193b-regulated signaling networks serve as tumor suppressors in liposarcoma and promote adipogenesis in adipose-derived stem cells.
Liver Cirrhosis
Angiogenic factor with G patch and FHA domains 1 (Aggf1) regulates liver fibrosis by modulating TGF-? signaling.
Liver Cirrhosis
DNMT1 controls LncRNA H19/ERK signal pathway in hepatic stellate cell activation and fibrosis.
Liver Cirrhosis
Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis.
Liver Cirrhosis
Epigenetic silencing of LncRNA ANRIL enhances liver fibrosis and HSC activation through activating AMPK pathway.
Liver Cirrhosis
LncRNA-SNHG7/miR-29b/DNMT3A axis affects activation, autophagy and proliferation of hepatic stellate cells in liver fibrosis.
Liver Cirrhosis
Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling.
Liver Cirrhosis
Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats.
Liver Cirrhosis
Salvianolic acid B-induced microRNA-152 inhibits liver fibrosis by attenuating DNMT1-mediated Patched1 methylation.
Liver Cirrhosis
Sennoside A prevents liver fibrosis by binding DNMT1 and suppressing DNMT1-mediated PTEN hypermethylation in HSC activation and proliferation.
Liver Cirrhosis
Sera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma.
Liver Cirrhosis
The interaction between microRNA-152 and DNA methyltransferase-1 as an epigenetic prognostic biomarker in HCV-induced liver cirrhosis and HCC patients.
Liver Cirrhosis, Biliary
Primary Biliary Cholangitis in British Columbia First Nations: Clinical features and discovery of novel genetic susceptibility loci.
Liver Diseases
Expression of proteins upregulated in hepatocellular carcinoma in patients with alcoholic hepatitis (AH) compared to non-alcoholic steatohepatitis (NASH): An immunohistochemical analysis of candidate proteins.
Liver Diseases
Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A.
Liver Diseases
Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo.
Liver Neoplasms
Antiproliferative Effects of Epigenetic Modifier Drugs Through E-cadherin Up-regulation in Liver Cancer Cell Lines.
Liver Neoplasms
Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells.
Liver Neoplasms
Correlative Analysis of DNA Methyltransferase Expression and Promoter Hypermethylation of Tumor Suppressor Genes in Hepatocellular Carcinoma.
Liver Neoplasms
DNA methyltransferase 3b silencing affects locus-specific DNA methylation and inhibits proliferation, migration and invasion in human hepatocellular carcinoma SMMC-7721 and BEL-7402 cells.
Liver Neoplasms
Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways.
Liver Neoplasms
LncRNA SNHG1 promotes liver cancer development through inhibiting p53 expression via binding to DNMT1.
Liver Neoplasms
miR-30a-3p inhibits the proliferation of liver cancer cells by targeting DNMT3a through the PI3K/AKT signaling pathway.
Liver Neoplasms
Overexpression of miR-450 affects the biological behavior of HepG2 cells by targeting DNMT3a.
Liver Neoplasms
The DNMT1/miR-34a/FOXM1 Axis Contributes to Stemness of Liver Cancer Cells.
Liver Neoplasms
[Growth inhibition and demethylation by a component of natural drug, CDP, in cancer cell lines]
Lung Injury
DNA methyltransferase inhibitor alleviates bleomycin-induced pulmonary inflammation.
Lung Injury
Regulatory T Cell DNA Methyltransferase Inhibition Accelerates Resolution of Lung Inflammation.
Lung Neoplasms
?-elemene inhibited expression of DNA methyltransferase 1 through activation of ERK1/2 and AMPK? signalling pathways in human lung cancer cells: the role of Sp1.
Lung Neoplasms
? DNMT3B4-del Contributes to Aberrant DNA Methylation Patterns in Lung Tumorigenesis.
Lung Neoplasms
A novel DNMT3B subfamily, DeltaDNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer.
Lung Neoplasms
A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer.
Lung Neoplasms
A regulatory circuit composed of DNA methyltransferases and receptor tyrosine kinases controls lung cancer cell aggressiveness.
Lung Neoplasms
Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells.
Lung Neoplasms
An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection.
Lung Neoplasms
Association of DNMT3B -283T>C polymorphism with risk of lung and gastric cancer: a case-control study and a meta-analysis.
Lung Neoplasms
Associations of DNMT3B -149C>T and -2437T>A polymorphisms and lung cancer risk in Chinese population.
Lung Neoplasms
Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation.
Lung Neoplasms
Chinese herbal medicine Xiaoji decoction inhibited growth of lung cancer cells through AMPK?-mediated inhibition of Sp1 and DNA methyltransferase 1.
Lung Neoplasms
Cigarette smoke induces demethylation of prometastatic oncogene synuclein-gamma in lung cancer cells by downregulation of DNMT3B.
Lung Neoplasms
Class I HDACs Are Mediators of Smoke Carcinogen-Induced Stabilization of DNMT1 and Serve as Promising Targets for Chemoprevention of Lung Cancer.
Lung Neoplasms
Combination of azacitidine and trichostatin A decreased the tumorigenic potential of lung cancer cells.
Lung Neoplasms
Combinations of DNA methyltransferase and histone deacetylase inhibitors induce DNA damage in small cell lung cancer cells: correlation of resistance with IFN-stimulated gene expression.
Lung Neoplasms
Corrigendum to "An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection" [Cancer Lett. 226 (1) (2005 Aug 8) 77-84].
Lung Neoplasms
Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis.
Lung Neoplasms
Decitabine reverses TGF-?1-induced epithelial-mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis.
Lung Neoplasms
Decreased miRNA-148a is associated with lymph node metastasis and poor clinical outcomes and functions as a suppressor of tumor metastasis in non-small cell lung cancer.
Lung Neoplasms
Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.
Lung Neoplasms
Delta DNMT3B variants regulate DNA methylation in a promoter-specific manner.
Lung Neoplasms
Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells.
Lung Neoplasms
Determination of O(6)-Methylguanine DNA Methyltransferase Promoter Methylation in Non-Small Cell Lung Cancer.
Lung Neoplasms
Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer.
Lung Neoplasms
Disabled-2 and Axin are concurrently colocalized and underexpressed in lung cancers.
Lung Neoplasms
Dissecting epigenetic silencing complexity in the mouse lung cancer suppressor gene Cadm1.
Lung Neoplasms
DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras.
Lung Neoplasms
DNA methyltransferase inhibition reverses epigenetically embedded phenotypes in lung cancer preferentially affecting polycomb target genes.
Lung Neoplasms
DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value.
Lung Neoplasms
DNMT1 promotes cell proliferation via methylating hMLH1 and hMSH2 promoters in EGFR-mutated non-small cell lung cancer.
Lung Neoplasms
Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.
Lung Neoplasms
DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer.
Lung Neoplasms
DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset.
Lung Neoplasms
Downregulation of DNMT3A by miR-708-5p Inhibits Lung Cancer Stem Cell-like Phenotypes through Repressing Wnt/?-catenin Signaling.
Lung Neoplasms
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
Lung Neoplasms
Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer.
Lung Neoplasms
Elevated mRNA levels of DNA methyltransferase-1 as an independent prognostic factor in primary nonsmall cell lung cancer.
Lung Neoplasms
Enhanced growth inhibition by combined DNA methylation/HDAC inhibitors in lung tumor cells with silenced CDKN2A.
Lung Neoplasms
Epigenetic Inactivation of the Tumor Suppressor IRX1 Occurs Frequently in Lung Adenocarcinoma and Its Silencing Is Associated with Impaired Prognosis.
Lung Neoplasms
Epigenetic mechanisms for silencing glutathione S-transferase m2 expression by hypermethylated specificity protein 1 binding in lung cancer.
Lung Neoplasms
Epigenetic-Based Biomarkers in the Malignant Transformation of BEAS-2B Cells Induced by Coal Tar Pitch Extract.
Lung Neoplasms
Essential role of DNA methyltransferase 1-mediated transcription of insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors.
Lung Neoplasms
Exploration of the relationship between DNA methyltransferase 1 and lung cancer screening.
Lung Neoplasms
Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer.
Lung Neoplasms
Expression of {Delta}DNMT3B Variants and Its Association with Promoter Methylation of p16 and RASSF1A in Primary Non-Small Cell Lung Cancer.
Lung Neoplasms
Genetic variations in epigenetic genes are predictors of recurrence in stage I or II non-small cell lung cancer patients.
Lung Neoplasms
Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer.
Lung Neoplasms
H3K27me3 induces multidrug resistance in small cell lung cancer by affecting HOXA1 DNA methylation via regulation of the lncRNA HOTAIR.
Lung Neoplasms
Hypoxic-stabilized EPAS1 proteins transactivate DNMT1 and cause promoter hypermethylation and transcription inhibition of EPAS1 in non-small cell lung cancer.
Lung Neoplasms
Identification of DBCCR1 as a suppressor in the development of lung cancer that is associated with increased DNA methyltransferase 1.
Lung Neoplasms
IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation.
Lung Neoplasms
Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.
Lung Neoplasms
Increased NQO1 but not c-MET and survivin expression in non-small cell lung carcinoma with KRAS mutations.
Lung Neoplasms
Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer.
Lung Neoplasms
Inhibition of DNA methyltransferase 1 by RNA interference reverses epithelial-mesenchymal transition in highly metastatic 95D lung cancer cells by inhibiting the Wnt signaling pathway.
Lung Neoplasms
Inhibition of EZH2 via activation of SAPK/JNK and reduction of p65 and DNMT1 as a novel mechanism in inhibition of human lung cancer cells by polyphyllin I.
Lung Neoplasms
Integrated analysis of miRNAs and DNA methylation identifies miR-132-3p as a tumor suppressor in lung adenocarcinoma.
Lung Neoplasms
Interaction Of c-Jun And HOTAIR- Increased Expression Of p21 Converge In Polyphyllin I-Inhibited Growth Of Human Lung Cancer Cells.
Lung Neoplasms
Lactate-fueled oxidative metabolism drives DNA methyltransferase 1-mediated transcriptional co-activator with PDZ binding domain protein activation.
Lung Neoplasms
LncRNA MIR210HG promotes proliferation and invasion of non-small cell lung cancer by upregulating methylation of CACNA2D2 promoter via binding to DNMT1.
Lung Neoplasms
LncRNA NEAT1 Interacted With DNMT1 to Regulate Malignant Phenotype of Cancer Cell and Cytotoxic T Cell Infiltration via Epigenetic Inhibition of p53, cGAS, and STING in Lung Cancer.
Lung Neoplasms
Long non-coding RNA AFAP1-AS1 plays an oncogenic role in promoting cell migration in non-small cell lung cancer.
Lung Neoplasms
Long noncoding RNA LINC00337 accelerates the non-small-cell lung cancer progression through inhibiting TIMP2 by recruiting DNMT1.
Lung Neoplasms
Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-?.
Lung Neoplasms
MDM2 Overexpression Deregulates the Transcriptional Control of RB/E2F Leading to DNA Methyltransferase 3A Overexpression in Lung Cancer.
Lung Neoplasms
Methylation of RILP in lung cancer promotes tumor cell proliferation and invasion.
Lung Neoplasms
Methylation of Wnt7a Is Modulated by DNMT1 and Cigarette Smoke Condensate in Non-Small Cell Lung Cancer.
Lung Neoplasms
MicroRNA-101 suppresses progression of lung cancer through the PTEN/AKT signaling pathway by targeting DNA methyltransferase 3A.
Lung Neoplasms
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.
Lung Neoplasms
MicroRNA-30a-3p inhibits the progression of lung cancer via the PI3K/AKT by targeting DNA methyltransferase 3a.
Lung Neoplasms
miR-185 and miR-29a are similarly expressed in the bronchoalveolar lavage cells in IPF and lung cancer but common targets DNMT1 and COL1A1 show disease specific patterns.
Lung Neoplasms
miRSNPs of miR1274 and miR3202 Genes that Target MeCP2 and DNMT3b Are Associated with Lung Cancer Risk: A Study Conducted on MassARRAY Genotyping.
Lung Neoplasms
Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells.
Lung Neoplasms
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Lung Neoplasms
Newly Synthesized DNA Methyltransferase Inhibitors as Radiosensitizers for Human Lung Cancer and Glioblastoma Cells.
Lung Neoplasms
No evidence of correlation between the single nucleotide polymorphism of DNMT3B promoter and gastric cancer risk in a Japanese population.
Lung Neoplasms
O6-Methylguanine-DNA methyltransferase hypermethylation modulated by 17beta-estradiol in lung cancer cells.
Lung Neoplasms
P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib.
Lung Neoplasms
Peperomin E reactivates silenced tumor suppressor genes in lung cancer cells via inhibition of DNA methyltransferase.
Lung Neoplasms
Polymorphisms in the DNA methyltransferase 3b gene and prostate cancer risk.
Lung Neoplasms
Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer.
Lung Neoplasms
Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome.
Lung Neoplasms
Restoration of miR-101 suppresses lung tumorigenesis through inhibition of DNMT3a-dependent DNA methylation.
Lung Neoplasms
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells.
Lung Neoplasms
SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome.
Lung Neoplasms
Silencing of miR-137 by aberrant promoter hypermethylation in surgically resected lung cancer.
Lung Neoplasms
Silibinin Synergizes with Histone Deacetylase and DNA Methyltransferase Inhibitors in Up-regulating E-cadherin Expression Together with Inhibition of Migration and Invasion of Human Non-small Cell Lung Cancer Cells.
Lung Neoplasms
Structural optimization of non-nucleoside DNA methyltransferase inhibitor as anti-cancer agent.
Lung Neoplasms
Targeting EP4 downstream c-Jun through ERK1/2-mediated reduction of DNMT1 reveals novel mechanism of solamargine-inhibited growth of lung cancer cells.
Lung Neoplasms
TGF-? induced EMT and stemness characteristics are associated with epigenetic regulation in lung cancer.
Lung Neoplasms
The DNA Methyltransferase 3B -149 Genetic Polymorphism Modulates Lung Cancer Risk from Smoking
Lung Neoplasms
The DNA Methyltransferase DNMT1 and Tyrosine-Protein Kinase KIT Cooperatively Promote Resistance to 5-Aza-2'-deoxycytidine (Decitabine) and Midostaurin (PKC412) in Lung Cancer Cells.
Lung Neoplasms
The DNMT3B -579G>T Polymorphism Is Significantly Associated With the Risk of Gastric Cancer but not Lung Cancer in Chinese Population.
Lung Neoplasms
The expression patterns and correlations of chibby, ?-catenin, and DNA methyltransferase-1 and their clinicopathological significance in lung cancers.
Lung Neoplasms
The inhibitory activity of gallic acid against DNA methylation: application of gallic acid on epigenetic therapy of human cancers.
Lung Neoplasms
The loss-of-function of DNA methyltransferase 1 by siRNA impairs the growth of non-small cell lung cancer with alleviated side effects via reactivation of RASSF1A and APC in vitro and vivo.
Lung Neoplasms
The Nonsteroidal Anti-Inflammatory Drug NS398 Reactivates SPARC Expression via Promoter Demethylation to Attenuate Invasiveness of Lung Cancer Cells.
Lung Neoplasms
The rs1550117 A>G variant in DNMT3A gene promoter significantly increases non-small cell lung cancer susceptibility in a Han Chinese population.
Lung Neoplasms
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients.
Lung Neoplasms
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in Laryngeal carcinoma.
Lung Neoplasms
Thyroid cancer 1 (C8orf4) shows high expression, no mutation and reduced methylation level in lung cancers, and its expression correlates with ?-catenin and DNMT1 expression and poor prognosis.
Lung Neoplasms
Upregulation of SPP1 Is a Marker for Poor Lung Cancer Prognosis and Contributes to Cancer Progression and Cisplatin Resistance.
Lung Neoplasms
USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and ?-TrCP and promotes cancer malignancy.
Lung Neoplasms
[Expression and significance of DNA methyltransferase in sera of patients with lung cancer].
Lung Neoplasms
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
Lung Neoplasms
[Lung cancer and its epigenetics association with chronic obstructive pulmonary disease].
Lung Neoplasms
[Protein expressions of HDAC1 and DNMT1 in non-small-cell lung cancer and its clinical significance].
Lung Neoplasms
[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].
Lung Neoplasms
[The Relationship of Clinicopathology of p16 in Non-small Cell Lung Cancer and 5-nitrogen impurity-2'-deoxycytidine-nitrogen Impurity on the Influence of p16 Expression in Lung Cancer A549 Cells].
Lupus Erythematosus, Systemic
A correlation study on the effects of DNMT1 on methylation levels in CD4(+) T cells of SLE patients.
Lupus Erythematosus, Systemic
Analysis of associations between the patterns of global DNA hypomethylation and expression of DNA methyltransferase in patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Association analyses of DNA methyltransferase-1 (DNMT1) polymorphisms with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Associations between aberrant DNA methylation and transcript levels of DNMT1 and MBD2 in CD4+T cells from patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Decreased Expression of Serine/Arginine-Rich Splicing Factor 1 in T Cells From Patients With Active Systemic Lupus Erythematosus Accounts for Reduced Expression of RasGRP1 and DNA Methyltransferase 1.
Lupus Erythematosus, Systemic
Effect of 5-azacytidine and procainamide on CD3-zeta chain expression in Jurkat T cells.
Lupus Erythematosus, Systemic
Genetic variants of DNMT3A and systemic lupus erythematosus susceptibility.
Lupus Erythematosus, Systemic
Global DNA methylation, DNMT1, and MBD2 in patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Mesenchymal Stem Cells Activate the MEK/ERK Signaling Pathway and Enhance DNA Methylation via DNMT1 in PBMC from Systemic Lupus Erythematosus.
Lupus Erythematosus, Systemic
MicroRNA-126 regulates DNA methylation in CD4(+) T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1.
Lupus Erythematosus, Systemic
MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1.
Lupus Erythematosus, Systemic
MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1.
Lupus Erythematosus, Systemic
Obesity promotes the global hypomethylation of CD4+ T cells in patients with systemic lupus erythematosus via downregulating DNMT1.
Lupus Erythematosus, Systemic
Possible role of DNA hypomethylation in the induction of SLE: relationship to the transcription of human endogenous retroviruses.
Lupus Erythematosus, Systemic
Prevalence of ZAP-70, LAT, SLP-76, and DNA methyltransferase 1 expression in CD4+ T cells of patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1.
Lupus Erythematosus, Systemic
Transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Ultraviolet B enhances DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus via inhibiting DNMT1 catalytic activity.
Lupus Erythematosus, Systemic
Ultraviolet B inhibition of DNMT1 activity via AhR activation dependent SIRT1 suppression in CD4+ T cells from systemic lupus erythematosus patients.
Lyme Disease
Characterization of a DNA Adenine Methyltransferase Gene of Borrelia hermsii and Its Dispensability for Murine Infection and Persistence.
Lymphatic Metastasis
Aberrant DNA methyltransferase 1 expression in clear cell renal cell carcinoma development and progression.
Lymphatic Metastasis
Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer.
Lymphatic Metastasis
Clinicopathological significance and prognostic value of DNA methyltransferase 1, 3a, and 3b expressions in sporadic epithelial ovarian cancer.
Lymphatic Metastasis
Disabled-2 and Axin are concurrently colocalized and underexpressed in lung cancers.
Lymphatic Metastasis
DNA methyltransferase 1 inhibits O6-methylguanine-DNAmethyl-transferase-mediated cell growth and metastasis of hypopharyngeal squamous carcinoma.
Lymphatic Metastasis
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis.
Lymphatic Metastasis
DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers.
Lymphatic Metastasis
DNMT3A overexpression is associated with aggressive behavior and enteroblastic differentiation of gastric adenocarcinoma.
Lymphatic Metastasis
Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma.
Lymphatic Metastasis
Effects of DNA methyltransferase 1 inhibition on esophageal squamous cell carcinoma.
Lymphatic Metastasis
Epigenetics and prostate cancer: defining the timing of DNA methyltransferase deregulation during prostate cancer progression.
Lymphatic Metastasis
Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro.
Lymphatic Metastasis
Reactivation of the homeotic tumor suppressor gene CDX2 by 5-aza-2'-deoxycytidine-induced demethylation inhibits cell proliferation and induces caspase-independent apoptosis in gastric cancer cells.
Lymphatic Metastasis
Single nucleotide polymorphism in DNA methyltransferase 3B promoter and its association with gastric cardiac adenocarcinoma in North China.
Lymphatic Metastasis
[Expression of DNA methyltransferase 1, 3A and 3B mRNA in the epithelial ovarian carcinoma]
Lymphatic Metastasis
[Expression of DNMT3b in human bladder cancer tissue and its correlation with clinical prognosis].
Lymphatic Metastasis
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
Lymphocytic Choriomeningitis
DNA methylation by DNA methyltransferase 1 is critical for effector CD8 T cell expansion.
Lymphoma
6-Thioguanine and zebularine down-regulate DNMT1 and globally demethylate canine malignant lymphoid cells.
Lymphoma
Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice.
Lymphoma
An essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas.
Lymphoma
Angioimmunoblastic T-cell lymphoma and myelodysplastic syndrome with mutations in TET2, DNMT3 and CUX1 - azacitidine induces only lymphoma remission.
Lymphoma
Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine in anaplastic large cell lymphoma.
Lymphoma
Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells.
Lymphoma
Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells.
Lymphoma
Comprehensive analysis of clinical, pathological, and genomic characteristics of follicular helper T-cell derived lymphomas.
Lymphoma
Dna methyltransferase 1 (DNMT1) gene activity in human lymphomas correlates with aberrant p53 gene expression.
Lymphoma
DNA methyltransferase 1-mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1-driven leukemogenesis.
Lymphoma
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells.
Lymphoma
Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma.
Lymphoma
Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis.
Lymphoma
Downregulation of miR-152 contributes to DNMT1-mediated silencing of SOCS3/SHP-1 in non-Hodgkin lymphoma.
Lymphoma
Effects of R type and S type ginsenoside Rg3 on DNA methylation in human hepatocarcinoma cells.
Lymphoma
Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells.
Lymphoma
Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1?-Induced Osteoarthritis Progression Through Regulating DNMT3A.
Lymphoma
Increased DNA methyltransferase 1 (DNMT1) gene expression in human lymphomas by fluorescent in situ hybridization.
Lymphoma
Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice.
Lymphoma
Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis.
Lymphoma
Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.
Lymphoma
Mutations found in cell-free DNAs of patients with malignant lymphoma at remission can derive from clonal hematopoiesis.
Lymphoma
Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a.
Lymphoma
Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity.
Lymphoma
Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas.
Lymphoma
Targeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A.
Lymphoma
The antitumor effects of arsenic trioxide in mantle cell lymphoma via targeting Wnt/??catenin pathway and DNA methyltransferase-1.
Lymphoma, B-Cell
AID assists DNMT1 to attenuate BCL6 expression through DNA methylation in diffuse large B-cell lymphoma cell lines.
Lymphoma, B-Cell
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
Lymphoma, B-Cell
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair.
Lymphoma, B-Cell
DNA methyltransferase DNMT3b protein overexpression as a prognostic factor in patients with diffuse large B-cell lymphomas.
Lymphoma, B-Cell
DNMT1 is associated with cell cycle and DNA replication gene sets in diffuse large B-cell lymphoma.
Lymphoma, B-Cell
DNMT1 is predictive of survival and associated with Ki-67 expression in R-CHOP-treated diffuse large B-cell lymphomas.
Lymphoma, B-Cell
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.
Lymphoma, B-Cell
Effects of R type and S type ginsenoside Rg3 on DNA methylation in human hepatocarcinoma cells.
Lymphoma, B-Cell
Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1?-Induced Osteoarthritis Progression Through Regulating DNMT3A.
Lymphoma, B-Cell
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Is inactivation of O(6)-methylguanine DNA methyltransferase still a favorable prognostic factor of patients with diffuse large B-cell lymphoma in the era of R-CHOP chemotherapy?
Lymphoma, B-Cell
Overexpression of DNA methyltransferase 1 as a negative independent prognostic factor in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab.
Lymphoma, B-Cell
Targeting the cancer epigenome: synergistic therapy with bromodomain inhibitors.
Lymphoma, B-Cell
Triplet Therapy with PD-1 Blockade, Histone Deacetylase Inhibitor, and DNA Methyltransferase Inhibitor Achieves Radiological Response in Refractory Double-Expressor Diffuse Large B-cell Lymphoma with 17p Deletion.
Lymphoma, Large B-Cell, Diffuse
AID assists DNMT1 to attenuate BCL6 expression through DNA methylation in diffuse large B-cell lymphoma cell lines.
Lymphoma, Large B-Cell, Diffuse
DNMT1 is associated with cell cycle and DNA replication gene sets in diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Is inactivation of O(6)-methylguanine DNA methyltransferase still a favorable prognostic factor of patients with diffuse large B-cell lymphoma in the era of R-CHOP chemotherapy?
Lymphoma, Large B-Cell, Diffuse
Overexpression of DNA methyltransferase 1 as a negative independent prognostic factor in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab.
Lymphoma, Large B-Cell, Diffuse
Triplet Therapy with PD-1 Blockade, Histone Deacetylase Inhibitor, and DNA Methyltransferase Inhibitor Achieves Radiological Response in Refractory Double-Expressor Diffuse Large B-cell Lymphoma with 17p Deletion.
Lymphoma, Large-Cell, Anaplastic
Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine in anaplastic large cell lymphoma.
Lymphoma, Large-Cell, Anaplastic
Targeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A.
Lymphoma, Mantle-Cell
The antitumor effects of arsenic trioxide in mantle cell lymphoma via targeting Wnt/??catenin pathway and DNA methyltransferase-1.
Lymphoma, Non-Hodgkin
Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1.
Lymphoma, Non-Hodgkin
Downregulation of miR-152 contributes to DNMT1-mediated silencing of SOCS3/SHP-1 in non-Hodgkin lymphoma.
Lymphoma, Non-Hodgkin
Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure.
Lymphoma, Non-Hodgkin
Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells.
Lymphoma, Non-Hodgkin
Suppression of metallothionein-I/II expression and its probable molecular mechanisms.
Lymphoma, T-Cell
A Survey of Somatic Mutations in 41 Genes in a Cohort of T-Cell Lymphomas Identifies Frequent Mutations in Genes Involved in Epigenetic Modification.
Lymphoma, T-Cell
An essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas.
Lymphoma, T-Cell
Angioimmunoblastic T-cell lymphoma and myelodysplastic syndrome with mutations in TET2, DNMT3 and CUX1 - azacitidine induces only lymphoma remission.
Lymphoma, T-Cell
Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms.
Lymphoma, T-Cell
Combined oral 5-azacytidine and romidepsin are highly effective in patients with PTCL: a multicenter phase 2 study.
Lymphoma, T-Cell
DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice.
Lymphoma, T-Cell
Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.
Lymphoma, T-Cell
Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing.
Lymphoma, T-Cell
Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas.
Lymphoma, T-Cell
The pathological features of angioimmunoblastic T-cell lymphomas with IDH2R172 mutations.
Lymphoma, T-Cell, Cutaneous
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
Lymphoma, T-Cell, Cutaneous
Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells.
Lymphoma, T-Cell, Cutaneous
Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas.
Lymphoma, T-Cell, Peripheral
Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma.
Lymphoma, T-Cell, Peripheral
Epigenetic modifiers: basic understanding and clinical development.
Lymphoma, T-Cell, Peripheral
Identification of cell-type-specific mutations in nodal T-cell lymphomas.
Lymphoproliferative Disorders
Chronic lymphoproliferative disorder of NK cells with TNFAIP3 and DNMT3A mutations.
Macrophage Activation Syndrome
Association of Clonal Hematopoiesis of Indeterminate Potential With Inflammatory Gene Expression in Patients With Severe Degenerative Aortic Valve Stenosis or Chronic Postischemic Heart Failure.
Malaria
A novel class of selective non-nucleoside inhibitors of human DNA methyltransferase 3A.
Mastocytoma
Isolation and characterization of proteins that stimulate the activity of mammalian DNA methyltransferase.
Mastocytoma
Mouse DNA-cytosine-5-methyltransferase: sequence specificity of the methylation reaction and electron microscopy of enzyme-DNA complexes.
Mastocytoma
Purification and characterization of mammalian DNA methyltransferases by use of monoclonal antibodies.
Mastocytoma
Reduced methyl group acceptance of 1-beta-D-arabinofuranosylcytosine-containing DNA polymers.
Mastocytosis
Epigenetic Changes in Neoplastic Mast Cells and Potential Impact in Mastocytosis.
Mastocytosis
Single Nucleotide Polymorphism Array Lesions, TET2, DNMT3A, ASXL1 and CBL Mutations Are Present in Systemic Mastocytosis.
Mastocytosis, Systemic
Single Nucleotide Polymorphism Array Lesions, TET2, DNMT3A, ASXL1 and CBL Mutations Are Present in Systemic Mastocytosis.
Medulloblastoma
Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma development.
Medulloblastoma
Effects of epigenetic modificators in combination with small molecule inhibitors of receptor tyrosine kinases on medulloblastoma growth.
Medulloblastoma
Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma.
Medulloblastoma
Erratum to: The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma.
Medulloblastoma
Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2.
Medulloblastoma
High expression of DNA methyltransferases in primary human medulloblastoma.
Medulloblastoma
Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling.
Medulloblastoma
MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes.
Medulloblastoma
The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma.
Medulloblastoma
The first case report of medulloblastoma associated with Tatton-Brown-Rahman syndrome.
Melanoma
A gene expression signature identifying transient DNMT1 depletion as a causal factor of cancer-germline gene activation in melanoma.
Melanoma
A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo.
Melanoma
Berberine induces apoptosis in human multiple myeloma cell line U266 through hypomethylation of p53 promoter.
Melanoma
Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation.
Melanoma
Comparative proteomics of human embryonic stem cells and embryonal carcinoma cells.
Melanoma
Correction: Ras and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation.
Melanoma
Cytotoxicity, DNA damage, and apoptosis induced by new fotemustine analogs on human melanoma cells in relation to O6-methylguanine DNA-methyltransferase expression.
Melanoma
DNA methylation-induced E-cadherin silencing is correlated with the clinicopathological features of melanoma.
Melanoma
DNMT1 and DNMT3B genetic polymorphisms affect the clinical course and outcome of melanoma patients.
Melanoma
DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR.
Melanoma
Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma.
Melanoma
DSS1 promoter hypomethylation and overexpression predict poor prognosis in melanoma and squamous cell carcinoma patients.
Melanoma
Epigenetic regulation by decitabine of melanoma differentiation in vitro and in vivo.
Melanoma
Epigenetic regulation of the transcription factor Foxa2 directs differential elafin expression in melanocytes and melanoma cells.
Melanoma
Expression of DNA Methyltransferase 1 Is a Hallmark of Melanoma, Correlating with Proliferation and Response to B-Raf and Mitogen-Activated Protein Kinase Inhibition in Melanocytic Tumors.
Melanoma
Impact of DNA methyltransferases on the epigenetic regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in malignant melanoma.
Melanoma
Induction of HLA-G expression in a melanoma cell line OCM-1A following the treatment with 5-aza-2'-deoxycytidine.
Melanoma
KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.
Melanoma
Metallothionein 1E is methylated in malignant melanoma and increases sensitivity to cisplatin-induced apoptosis.
Melanoma
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Melanoma
MGMT promoter methylation is associated with temozolomide response and prolonged progression-free survival in disseminated cutaneous melanoma.
Melanoma
MiR-211 is epigenetically regulated by DNMT1 mediated methylation and inhibits EMT of melanoma cells by targeting RAB22A.
Melanoma
O(6)-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C.
Melanoma
Promoter hypermethylation of the O(6)-methylguanine DNA methyltransferase gene and microsatellite instability in metastatic melanoma.
Melanoma
Randomized trial of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemotherapy naive patients with metastatic cutaneous melanoma.
Melanoma
Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treatment with Temozolomide In Vitro and In Vivo.
Melanoma
Ras and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation.
Melanoma
Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells.
Melanoma
Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell lines.
Melanoma
Spitz nevi and Spitzoid melanomas: exome sequencing and comparison with conventional melanocytic nevi and melanomas.
Melanoma
SUV39H1/DNMT3A-dependent methylation of the RB1 promoter stimulates PIN1 expression and melanoma development.
Melanoma
Synergistic silencing by promoter methylation and reduced AP-2? transactivation of the proapoptotic HRK gene confers apoptosis resistance and enhanced tumor growth.
Melanoma
Temozolomide chemoresistance heterogeneity in melanoma with different treatment regimens: DNA damage accumulation contribution.
Melanoma
TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models.
Melanoma
The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells.
Melanoma
The Cancer/Testis Antigen Gene VCX2 Is Rarely Expressed in Malignancies but Can Be Epigenetically Activated Using DNA Methyltransferase and Histone Deacetylase Inhibitors.
Melanoma
Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells.
Melanoma
Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors.
Melanoma
Unbiased High-Throughput Drug Combination Pilot Screening Identifies Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines.
Melanosis
DNA Methyltransferases in Malar Melasma and Their Modification by Sunscreen in Combination with 4% Niacinamide, 0.05% Retinoic Acid, or Placebo.
Memory Disorders
Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer's disease.
Memory Disorders
Hippocampal chromatin-modifying enzymes are pivotal for scopolamine-induced synaptic plasticity gene expression changes and memory impairment.
Memory Disorders
Prolonged febrile seizures induce inheritable memory deficits in rats through DNA methylation.
Memory Disorders
Virus-mediated Dnmt1 and Dnmt3a deletion disrupts excitatory synaptogenesis and synaptic function in primary cultured hippocampal neurons.
Meningioma
Radiation-induced hypomethylation triggers urokinase plasminogen activator transcription in meningioma cells.
Meningioma
The role and regulatory mechanism of IL-1? on the methylation of the NF2 gene in benign meningiomas and leptomeninges.
Menopause, Premature
Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women.
Mesothelioma
Asbestos Induces Epigenetic Repression of Ras Association Domain-Containing Protein 1, p16 Kinase 4a Inhibitor, and p14 Alternative Reading Frame in Normal Human Mesothelial Cells.
Mesothelioma
Decitabine, differently from DNMT1 silencing, exerts its antiproliferative activity through p21 upregulation in malignant pleural mesothelioma (MPM) cells.
Mesothelioma
Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells.
Mesothelioma, Malignant
Asbestos Induces Epigenetic Repression of Ras Association Domain-Containing Protein 1, p16 Kinase 4a Inhibitor, and p14 Alternative Reading Frame in Normal Human Mesothelial Cells.
Mesothelioma, Malignant
Decitabine, differently from DNMT1 silencing, exerts its antiproliferative activity through p21 upregulation in malignant pleural mesothelioma (MPM) cells.
Mesothelioma, Malignant
Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells.
Mesothelioma, Malignant
Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma.
Mesothelioma, Malignant
Zebularine exerts its antiproliferative activity through S phase delay and cell death in human malignant mesothelioma cells.
Metabolic Syndrome
Botanicals as epigenetic modulators for mechanisms contributing to development of metabolic syndrome.
Microcephaly
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.
Microcephaly
Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility.
Monoclonal Gammopathy of Undetermined Significance
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Mouth Neoplasms
A novel melatonin-regulated lncRNA suppresses TPA-induced oral cancer cell motility through replenishing PRUNE2 expression.
Mouth Neoplasms
MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1.
Mouth Neoplasms
MiR-30a and miR-379 modulate retinoic acid pathway by targeting DNA methyltransferase 3B in oral cancer.
Mucopolysaccharidosis I
Whole exome sequencing unravels disease-causing genes in consanguineous families in Qatar.
Multiple Endocrine Neoplasia
Tissue-specific induced DNA methyltransferase 1 (Dnmt1) in endocrine pancreas by RCAS-TVA-based somatic gene transfer system promotes ?-cell proliferation.
Multiple Endocrine Neoplasia Type 1
Tissue-specific induced DNA methyltransferase 1 (Dnmt1) in endocrine pancreas by RCAS-TVA-based somatic gene transfer system promotes ?-cell proliferation.
Multiple Myeloma
5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells.
Multiple Myeloma
Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myeloma.
Multiple Myeloma
DNA methylation inhibition in myeloma: Experience from a phase 1b study of low-dose continuous azacitidine in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma.
Multiple Myeloma
DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma.
Multiple Myeloma
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Multiple Myeloma
Epigenetic treatment of multiple myeloma mediates tumor intrinsic and extrinsic immunomodulatory effects.
Multiple Myeloma
HDAC3 regulates DNMT1 expression in multiple myeloma: therapeutic implications.
Multiple Myeloma
In vivo treatment with epigenetic modulating agents induces transcriptional alterations associated with prognosis and immunomodulation in multiple myeloma.
Multiple Myeloma
Knockdown of DNA methyltransferase-1 inhibits proliferation and derepresses tumor suppressor genes in myeloma cells.
Multiple Myeloma
Methylation of the Promoter Region of the Tight Junction Protein-1 by DNMT1 Induces EMT-like Features in Multiple Myeloma.
Multiple Myeloma
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Multiple Myeloma
Myeloid-derived suppressor cells endow stem-like qualities to multiple myeloma cells by inducing piRNA-823 expression and DNMT3B activation.
Multiple Myeloma
The role of DNA damage and repair in decitabine-mediated apoptosis in multiple myeloma.
Muscular Atrophy
DNA methyltransferase 3a and mitogen-activated protein kinase signaling regulate the expression of fibroblast growth factor-inducible 14 (Fn14) during denervation-induced skeletal muscle atrophy.
Muscular Atrophy
Overexpression of Dnmt3a ameliorates diabetic muscle atrophy by modulating Pten/Akt pathway.
Muscular Atrophy
Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration.
Muscular Atrophy, Spinal
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Muscular Dystrophies
Hypomethylation is restricted to the D4Z4 repeat array in phenotypic FSHD.
Muscular Dystrophy, Facioscapulohumeral
A Pediatric Review of Facioscapulohumeral Muscular Dystrophy.
Muscular Dystrophy, Facioscapulohumeral
SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes.
Myasthenia Gravis
Association of the DNMT3B -579G>T polymorphism with risk of thymomas in patients with myasthenia gravis.
Myasthenia Gravis
Downregulation of DNMT3a expression by RNAi and its effect on NF-?Bs expression of thymic epithelial cells.
Myelodysplastic Syndromes
5-Aza-2'-Deoxycytidine and DNA Methyltransferase Inhibitors in the Treatment of Myeloid Leukemias and Myelodysplastic Syndromes: Biological Aspects and Clinical Results. Proceedings of a workshop. Rome, Italy, November 3, 1991.
Myelodysplastic Syndromes
5-Aza-4'-thio-2'-deoxycytidine, a new orally bioavailable non-toxic "best-in-class" DNMT1 depleting agent in clinical development.
Myelodysplastic Syndromes
5-Azacytidine Transiently Restores Dysregulated Erythroid Differentiation Gene Expression in TET2-Deficient Erythroleukemia Cells.
Myelodysplastic Syndromes
A carrier-mediated prodrug approach to improve the oral absorption of antileukemic drug decitabine.
Myelodysplastic Syndromes
Acquired elliptocytosis as presenting sign of a myelodysplastic syndrome associated with deletion of chromosome 20 and mutations in TET2, DNMT3A, and U2AF1.
Myelodysplastic Syndromes
An miRNA-DNMT1 Axis Is Involved in Azacitidine Resistance and Predicts Survival in Higher-Risk Myelodysplastic Syndrome and Low Blast Count Acute Myeloid Leukemia.
Myelodysplastic Syndromes
Angioimmunoblastic T-cell lymphoma and myelodysplastic syndrome with mutations in TET2, DNMT3 and CUX1 - azacitidine induces only lymphoma remission.
Myelodysplastic Syndromes
Azacytidine causes complex DNA methylation responses in myeloid leukemia.
Myelodysplastic Syndromes
Cedazuridine/decitabine: from preclinical to clinical development in myeloid malignancies.
Myelodysplastic Syndromes
Characterization of DNA demethylation effects induced by 5-Aza-2'-deoxycytidine in patients with myelodysplastic syndrome.
Myelodysplastic Syndromes
Chromatin Regulation by HP1? Contributes to Survival of 5-Azacytidine-Resistant Cells.
Myelodysplastic Syndromes
Clinical activity and safety of the dual pathway inhibitor rigosertib for higher risk myelodysplastic syndromes following DNA methyltransferase inhibitor therapy.
Myelodysplastic Syndromes
Clinical Advances in Hypomethylating Agents Targeting Epigenetic Pathways.
Myelodysplastic Syndromes
Comparison of 7-day azacitidine and 5-day decitabine for treating myelodysplastic syndrome.
Myelodysplastic Syndromes
Comparison of SF3B1/DNMT3A Comutations With DNMT3A or SF3B1 Mutation Alone in Myelodysplastic Syndrome and Clonal Cytopenia of Undetermined Significance.
Myelodysplastic Syndromes
Depletion of ZBTB38 potentiates the effects of DNA demethylating agents in cancer cells via CDKN1C mRNA up-regulation.
Myelodysplastic Syndromes
Developmental DNA methyltransferase inhibitors in the treatment of gynecologic cancers.
Myelodysplastic Syndromes
Differentiation therapy in poor risk myeloid malignancies: Results of a dose finding study of the combination bryostatin-1 and GM-CSF.
Myelodysplastic Syndromes
DNA methylation changes following 5-azacitidine treatment in patients with myelodysplastic syndrome.
Myelodysplastic Syndromes
DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes.
Myelodysplastic Syndromes
DNA Methyltransferase Inhibitors in Myeloid Cancer: Clonal Eradication or Clonal Differentiation?
Myelodysplastic Syndromes
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
Myelodysplastic Syndromes
DNMT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia.
Myelodysplastic Syndromes
DNMT3a mutations in high-risk myelodysplastic syndrome parallel those found in acute myeloid leukemia.
Myelodysplastic Syndromes
DNMT3A R882 mutations in patients with cytogenetically normal acute myeloid leukemia and myelodysplastic syndrome.
Myelodysplastic Syndromes
Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.
Myelodysplastic Syndromes
Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic syndrome.
Myelodysplastic Syndromes
Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells.
Myelodysplastic Syndromes
Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-derived cell lines.
Myelodysplastic Syndromes
Epigenetic modifiers: basic understanding and clinical development.
Myelodysplastic Syndromes
Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries.
Myelodysplastic Syndromes
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
Myelodysplastic Syndromes
Expression levels of DNA methyltransferase genes do not correlate with p15INK4B gene methylation in myelodysplastic syndromes.
Myelodysplastic Syndromes
FLT3-ITD, NPM1, and DNMT3A Gene Mutations and Risk Factors in Normal Karyotype Acute Myeloid Leukemia and Myelodysplastic Syndrome Patients in Upper Northern Thailand
Myelodysplastic Syndromes
Hydralazine and magnesium valproate as epigenetic treatment for myelodysplastic syndrome. Preliminary results of a phase-II trial.
Myelodysplastic Syndromes
Hypomethylating Agents in the Treatment of Myelodysplastic Syndromes and Myeloid Leukemia.
Myelodysplastic Syndromes
Identification of novel DNA methylation inhibitors via a two-component reporter gene system.
Myelodysplastic Syndromes
IDH mutations are closely associated with mutations of DNMT3A, ASXL1 and SRSF2 in patients with myelodysplastic syndromes and are stable during disease evolution.
Myelodysplastic Syndromes
Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms.
Myelodysplastic Syndromes
Increased CDA expression/activity in males contributes to decreased cytidine analog half-life and likely contributes to worse outcomes with 5-azacytidine or decitabine therapy.
Myelodysplastic Syndromes
Intragenic hypomethylation of DNMT3A in patients with myelodysplastic syndrome.
Myelodysplastic Syndromes
Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy.
Myelodysplastic Syndromes
Longitudinal Analysis of DNA Methylation in CD34+ Hematopoietic Progenitors in Myelodysplastic Syndrome.
Myelodysplastic Syndromes
Low-Dose Azacitidine with DNMT1 Level Monitoring to Treat Post-Transplantation Acute Myelogenous Leukemia or Myelodysplastic Syndrome Relapse.
Myelodysplastic Syndromes
MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation.
Myelodysplastic Syndromes
Mutations in genes affecting DNA methylation enhances responses to decitabine in patients with myelodysplastic syndrome.
Myelodysplastic Syndromes
New ways to use DNA methyltransferase inhibitors for the treatment of myelodysplastic syndrome.
Myelodysplastic Syndromes
Noncanonical immune response to the inhibition of DNA methylation by Staufen1 via stabilization of endogenous retrovirus RNAs.
Myelodysplastic Syndromes
Novel approaches for myelodysplastic syndromes: beyond hypomethylating agents.
Myelodysplastic Syndromes
On the potential role of DNMT1 in acute myeloid leukemia and myelodysplastic syndromes: not another mutated epigenetic driver.
Myelodysplastic Syndromes
Opposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms.
Myelodysplastic Syndromes
Optimizing therapy with methylation inhibitors in myelodysplastic syndromes: dose, duration, and patient selection.
Myelodysplastic Syndromes
Oral Azacitidine and Cedazuridine Approximate Parenteral Azacitidine Efficacy in Murine Model.
Myelodysplastic Syndromes
Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia.
Myelodysplastic Syndromes
Persistence of DNMT3A mutations at long-term remission in adult patients with AML.
Myelodysplastic Syndromes
Pharmacokinetic evaluation of decitabine for the treatment of leukemia.
Myelodysplastic Syndromes
Phase I and II study of azacitidine in Japanese patients with myelodysplastic syndromes.
Myelodysplastic Syndromes
Phase II study of targeted therapy with temozolomide in acute myeloid leukaemia and high-risk myelodysplastic syndrome patients pre-screened for low O(6) -methylguanine DNA methyltransferase expression.
Myelodysplastic Syndromes
Prognostic value of DNMT3A mutations in myelodysplastic syndromes: a meta-analysis.
Myelodysplastic Syndromes
Proteomic analysis identifies differentially expressed proteins in AML1/ETO acute myeloid leukemia cells treated with DNMT inhibitors azacitidine and decitabine.
Myelodysplastic Syndromes
QbD Enabled Azacitidine Loaded Liposomal Nanoformulation and Its In Vitro Evaluation.
Myelodysplastic Syndromes
Rare mutations in DNMT3A in myeloproliferative neoplasms and myelodysplastic syndromes.
Myelodysplastic Syndromes
Rare occurrence of DNMT3A mutations in myelodysplastic syndromes.
Myelodysplastic Syndromes
Real-time nanoscale proteomic analysis of the novel multi-kinase pathway inhibitor rigosertib to measure the response to treatment of cancer.
Myelodysplastic Syndromes
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes.
Myelodysplastic Syndromes
Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.
Myelodysplastic Syndromes
Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects.
Myelodysplastic Syndromes
Six (or more) drugs in search of a mechanism: DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes.
Myelodysplastic Syndromes
Targeted TET oxidase activity through methyl-CpG-binding domain extensively suppresses cancer cell proliferation.
Myelodysplastic Syndromes
Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL).
Myelodysplastic Syndromes
TERT and DNMT1 expression predict sensitivity to decitabine in gliomas.
Myelodysplastic Syndromes
The clinical use of DNA methyltransferase inhibitors in myelodysplastic syndromes.
Myelodysplastic Syndromes
The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells.
Myelodysplastic Syndromes
The effects of 5-azacytidine on the function and number of regulatory T-cells and T-effectors in myelodysplastic syndrome.
Myelodysplastic Syndromes
The role of autophagy in targeted therapy for acute myeloid leukemia.
Myelodysplastic Syndromes
Treatment of myelodysplastic syndrome with a DNA methyltransferase inhibitor: lack of evidence for induction of chromosomal instability.
Myelodysplastic Syndromes
Up-regulation of DNA methyltransferases DNMT1, 3A, and 3B in myelodysplastic syndrome.
Myelodysplastic Syndromes
Utility of DNA methyltransferase inhibitors for the treatment of myelodysplastic syndromes.
Myelodysplastic Syndromes
[The expression of DNA methyltransferase DNMT1, 3A and 3B in acute leukemia and myelodysplastic syndrome]
Myocardial Infarction
Clonal hematopoiesis of indeterminate potential-associated mutations and risk of comorbidities in patients with myelodysplastic syndrome.
Myocardial Infarction
DNA methylation regulates ?-smooth muscle actin expression during cardiac fibroblast differentiation.
Narcolepsy
A novel de novo exon 21 DNMT1 mutation causes cerebellar ataxia, deafness, and narcolepsy in a Brazilian patient.
Narcolepsy
A novel DNMT1 mutation associated with early onset hereditary sensory and autonomic neuropathy, cataplexy, cerebellar atrophy, scleroderma, endocrinopathy, and common variable immune deficiency.
Narcolepsy
Aberrant signature methylome by DNMT1 hot spot mutation in hereditary sensory and autonomic neuropathy 1E.
Narcolepsy
Autosomal dominant cerebellar ataxia, deafness, and narcolepsy (ADCA-DN) associated with progressive cognitive and behavioral deterioration.
Narcolepsy
Cerebellar Ataxia as a Common Clinical Presentation Associated with DNMT1 p.Y511H and a Review of the Literature.
Narcolepsy
DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?
Narcolepsy
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
Narcolepsy
Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy.
Narcolepsy
Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy.
Narcolepsy
Novel mutation in the replication focus targeting sequence domain of DNMT1 causes hereditary sensory and autonomic neuropathy IE.
Narcolepsy
Polysomnographic and neurometabolic features may mark preclinical autosomal dominant cerebellar ataxia, deafness, and narcolepsy due to a mutation in the DNA (cytosine-5-)-methyltransferase gene, DNMT1.
Nasopharyngeal Carcinoma
Activation of DNA methyltransferase 1 by EBV LMP1 Involves c-Jun NH(2)-terminal kinase signaling.
Nasopharyngeal Carcinoma
Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/Wnt inhibitory factor 1 (WIF1) axis.
Nasopharyngeal Carcinoma
DNMT1 mediates metabolic reprogramming induced by Epstein-Barr virus latent membrane protein 1 and reversed by grifolin in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Gene expression and promoter polymorphisms of DNA methyltransferase 3B in nasopharyngeal carcinomas in Taiwanese people: a case-control study.
Nasopharyngeal Carcinoma
Inhibition of DNA methyltransferase as a novel therapeutic strategy to overcome acquired resistance to dual PI3K/mTOR inhibitors.
Nasopharyngeal Carcinoma
Interplay of DNA methyltransferase 1 and EZH2 through inactivation of Stat3 contributes to ?-elemene-inhibited growth of nasopharyngeal carcinoma cells.
Nasopharyngeal Carcinoma
MiR-152 functioning as a tumor suppressor that interacts with DNMT1 in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
MiR-29c regulates the expression of miR-34c and miR-449a by targeting DNA methyltransferase 3a and 3b in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
O(6) -methylguanine DNA methyltransferase repairs platinum-DNA adducts following cisplatin treatment and predicts prognoses of nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Neoplasm Metastasis
A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1.
Neoplasm Metastasis
Aberrant DNA methyltransferase 1 expression in clear cell renal cell carcinoma development and progression.
Neoplasm Metastasis
Alterations of metastasis-related genes identified using an oligonucleotide microarray of genistein-treated HCC1395 breast cancer cells.
Neoplasm Metastasis
An essential role for DNA methyltransferase 3a in melanoma tumorigenesis.
Neoplasm Metastasis
Chlorogenic Acid Decreases Malignant Characteristics of Hepatocellular Carcinoma Cells by Inhibiting DNMT1 Expression.
Neoplasm Metastasis
circ0093740 Promotes Tumor Growth and Metastasis by Sponging miR-136/145 and Upregulating DNMT3A in Wilms Tumor.
Neoplasm Metastasis
Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer.
Neoplasm Metastasis
Clinicopathological significance and prognostic value of DNA methyltransferase 1, 3a, and 3b expressions in sporadic epithelial ovarian cancer.
Neoplasm Metastasis
Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis.
Neoplasm Metastasis
Deep MicroRNA sequencing reveals downregulation of miR-29a in neuroblastoma central nervous system metastasis.
Neoplasm Metastasis
Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, affecting cell migration and invasion in gastric cancer.
Neoplasm Metastasis
DNA methyltransferase 1 inhibits O6-methylguanine-DNAmethyl-transferase-mediated cell growth and metastasis of hypopharyngeal squamous carcinoma.
Neoplasm Metastasis
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis.
Neoplasm Metastasis
DNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27/H3K9 methylation in EMT-related metastasis of gastric cancer.
Neoplasm Metastasis
DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers.
Neoplasm Metastasis
DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis.
Neoplasm Metastasis
DNMT3A overexpression is associated with aggressive behavior and enteroblastic differentiation of gastric adenocarcinoma.
Neoplasm Metastasis
Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma.
Neoplasm Metastasis
Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells.
Neoplasm Metastasis
Effects of DNA methyltransferase 1 inhibition on esophageal squamous cell carcinoma.
Neoplasm Metastasis
Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma.
Neoplasm Metastasis
Epigenetic regulation of HGF/Met receptor axis is critical for the outgrowth of bone metastasis from breast carcinoma.
Neoplasm Metastasis
Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer.
Neoplasm Metastasis
Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma.
Neoplasm Metastasis
Epigenetics and prostate cancer: defining the timing of DNA methyltransferase deregulation during prostate cancer progression.
Neoplasm Metastasis
Expression of DNA methylation-related proteins in metastatic breast cancer.
Neoplasm Metastasis
Expression of human DNA methyltransferase 1 in colorectal cancer tissues and their corresponding distant normal tissues.
Neoplasm Metastasis
Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro.
Neoplasm Metastasis
EZH2-DNMT1-mediated epigenetic silencing of miR-142-3p promotes metastasis through targeting ZEB2 in nasopharyngeal carcinoma.
Neoplasm Metastasis
FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter.
Neoplasm Metastasis
Functions and Epigenetic Regulation of Wwox in Bone Metastasis from Breast Carcinoma: Comparison with Primary Tumors.
Neoplasm Metastasis
GAD1 Upregulation Programs Aggressive Features of Cancer Cell Metabolism in the Brain Metastatic Microenvironment.
Neoplasm Metastasis
Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis.
Neoplasm Metastasis
Human breast cancer progression can be regulated by dominant trans-acting factors in somatic cell hybridization studies.
Neoplasm Metastasis
IL-8 suppresses E-cadherin expression in nasopharyngeal carcinoma cells by enhancing E-cadherin promoter DNA methylation.
Neoplasm Metastasis
Inhibition of DNA methyltransferase 1 by RNA interference reverses epithelial-mesenchymal transition in highly metastatic 95D lung cancer cells by inhibiting the Wnt signaling pathway.
Neoplasm Metastasis
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Neoplasm Metastasis
lncRNA H19 regulates epithelial-mesenchymal transition and metastasis of bladder cancer by miR-29b-3p as competing endogenous RNA.
Neoplasm Metastasis
Long non-coding RNA HCP5 functions as a sponge of miR-29b-3p and promotes cell growth and metastasis in hepatocellular carcinoma through upregulating DNMT3A.
Neoplasm Metastasis
Loss of Chromatin Remodeling Proteins and/or CDKN2A Associates With Metastasis of Pancreatic Neuroendocrine Tumors and Reduced Patient Survival Times.
Neoplasm Metastasis
Loss of exosomal miR-148b from cancer-associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis.
Neoplasm Metastasis
Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase.
Neoplasm Metastasis
Methylation-Induced Silencing of ALDH2 Facilitates Lung Adenocarcinoma Bone Metastasis by Activating the MAPK Pathway.
Neoplasm Metastasis
MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway.
Neoplasm Metastasis
miR-200b restoration and DNA methyltransferase inhibitor block lung metastasis of mesenchymal-phenotype hepatocellular carcinoma.
Neoplasm Metastasis
miR-492 promotes chemoresistance to CDDP and metastasis by targeting inhibiting DNMT3B and induces stemness in gastric cancer.
Neoplasm Metastasis
Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma.
Neoplasm Metastasis
Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells.
Neoplasm Metastasis
Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.
Neoplasm Metastasis
MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma.
Neoplasm Metastasis
Mutations in DNMT3A and loss of RKIP are independent events in acute monocytic leukemia.
Neoplasm Metastasis
Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma.
Neoplasm Metastasis
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.
Neoplasm Metastasis
Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer.
Neoplasm Metastasis
Over-expression of DNMT3A predicts the risk of recurrent vulvar squamous cell carcinomas.
Neoplasm Metastasis
Physcion 8-O-?-glucopyranoside suppresses the metastasis of breast cancer in vitro and in vivo by modulating DNMT1.
Neoplasm Metastasis
Promoter polymorphisms of DNMT3B and the risk of head and neck squamous cell carcinoma in Taiwan: a case-control study.
Neoplasm Metastasis
Reactivation of the homeotic tumor suppressor gene CDX2 by 5-aza-2'-deoxycytidine-induced demethylation inhibits cell proliferation and induces caspase-independent apoptosis in gastric cancer cells.
Neoplasm Metastasis
Retraction Note to: Physcion 8-O-?-glucopyranoside suppresses the metastasis of breast cancer in vitro and in vivo by modulating DNMT1.
Neoplasm Metastasis
Silencing DNA methyltransferase 1 (DNMT1) inhibits proliferation, metastasis and invasion in ESCC by suppressing methylation of RASSF1A and DAPK.
Neoplasm Metastasis
Silencing of the Metastasis Suppressor RECK by RAS Oncogene Is Mediated by DNA Methyltransferase 3b-Induced Promoter Methylation.
Neoplasm Metastasis
Targeted inhibition of genome-wide DNA methylation analysis in epigenetically modulated phenotypes in lung cancer.
Neoplasm Metastasis
The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer.
Neoplasm Metastasis
The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy.
Neoplasm Metastasis
The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma.
Neoplasm Metastasis
The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma.
Neoplasm Metastasis
Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis.
Neoplasm Metastasis
[Expression of DNMT3b in human bladder cancer tissue and its correlation with clinical prognosis].
Neoplasm Metastasis
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
Neoplasm Metastasis
[High expression of DNMT3B promotes proliferation and invasion of hepatocellular carcinoma cells via Hippo signaling pathway].
Neoplasm, Residual
DNMT3A mutant transcript levels persist in remission and do not predict outcome in patients with acute myeloid leukemia.
Neoplasm, Residual
DNMT3A mutations and prognostic significance in childhood acute lymphoblastic leukemia.
Neoplasm, Residual
DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications.
Neoplasm, Residual
IDH1/2 but not DNMT3A mutations are suitable targets for minimal residual disease monitoring in acute myeloid leukemia patients: a study by the Acute Leukemia French Association.
Neoplasm, Residual
Integrated epigenetic and genetic analysis identifies markers of prognostic significance in pediatric acute myeloid leukemia.
Neoplasm, Residual
Limited role for extended maintenance temozolomide for newly diagnosed glioblastoma.
Neoplasm, Residual
Persistence of DNMT3A mutations at long-term remission in adult patients with AML.
Neoplasm, Residual
Predictive factors for the sensitivity of radiotherapy and prognosis of esophageal squamous cell carcinoma.
Neoplasm, Residual
Two Novel Methods for Rapid Detection and Quantification of DNMT3A R882 Mutations in Acute Myeloid Leukemia.
Neoplasms
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Induces Retinoic Acid Receptor ? Hypermethylation through DNA Methyltransferase 1 Accumulation in Esophageal Squamous Epithelial Cells.
Neoplasms
5,6 Dihydro-5'-azacytidine (DHAC) restores androgen responsiveness in androgen-insensitive prostate cancer cells.
Neoplasms
5-Aza-2'-deoxycytidine induces a greater inflammatory change, at the molecular levels, in normoxic than hypoxic tumor microenvironment.
Neoplasms
5-Aza-4'-thio-2'-deoxycytidine, a new orally bioavailable non-toxic "best-in-class" DNMT1 depleting agent in clinical development.
Neoplasms
5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats.
Neoplasms
A colorimetric assay of DNA methyltransferase activity based on peroxidase mimicking of DNA template Ag/Pt bimetallic nanoclusters.
Neoplasms
A colorimetric assay of DNA methyltransferase activity based on the keypad lock of duplex DNA modified meso-SiO2@Fe3O4.
Neoplasms
A Comparative Study on the In Vitro Effects of the DNA Methyltransferase Inhibitor 5-Azacytidine (5-AzaC) in Breast/Mammary Cancer of Different Mammalian Species.
Neoplasms
A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation.
Neoplasms
A concern regarding the current confusion with the human homolog of mouse Np95, ICBP90/UHRF1.
Neoplasms
A DNA as a Substrate and an Enzyme: Direct Profiling of Methyltransferase Activity by Cytosine Methylation of a DNAzyme.
Neoplasms
A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer.
Neoplasms
A dual amplification fluorescent strategy for sensitive detection of DNA methyltransferase activity based on strand displacement amplification and DNAzyme amplification.
Neoplasms
A feedback loop: Interactions between Inflammatory Signals and Clonal Hematopoiesis in Cardiovascular Disease.
Neoplasms
A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs.
Neoplasms
A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers.
Neoplasms
A long intergenic non-coding RNA regulates nuclear localization of DNA methyl transferase-1.
Neoplasms
A mass balance and disposition study of the DNA methyltransferase inhibitor zebularine (NSC 309132) and three of its metabolites in mice.
Neoplasms
A methylation-blocked cascade amplification strategy for label-free colorimetric detection of DNA methyltransferase activity.
Neoplasms
A microassay for measuring cytosine DNA methyltransferase activity during tumor progression.
Neoplasms
A microchip electrophoretic assay for DNA methyltransferase activity based on methylation-sensitive endonuclease Dpn?.
Neoplasms
A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor.
Neoplasms
A Model System for Studying the DNMT3A Hotspot Mutation (DNMT3AR882) Demonstrates a Causal Relationship between Its Dominant-Negative Effect and Leukemogenesis.
Neoplasms
A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation.
Neoplasms
A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation.
Neoplasms
A new tumor suppressor LncRNA ADAMTS9-AS2 is regulated by DNMT1 and inhibits migration of glioma cells.
Neoplasms
A Novel 85-Gene Expression Signature Predicts Unfavorable Prognosis in Acute Myeloid Leukemia.
Neoplasms
A novel DNA biosensor for the ultrasensitive detection of DNA methyltransferase activity based on a high-density "hot spot" SERS substrate and rolling circle amplification strategy.
Neoplasms
A novel DNA methyltransferase I-derived peptide eluted from soluble HLA-A*0201 induces peptide-specific, tumor-directed cytotoxic T cells.
Neoplasms
A Novel DNMT3B Splice Variant Expressed in Tumor and Pluripotent Cells Modulates Genomic DNA Methylation Patterns and Displays Altered DNA Binding.
Neoplasms
A Novel Functional TagSNP Rs7560488 in the DNMT3A1 Promoter Is Associated with Susceptibility to Gastric Cancer by Modulating Promoter Activity.
Neoplasms
A novel label-free fluorescence strategy for methyltransferase activity assay based on dsDNA-templated copper nanoparticles coupled with an endonuclease-assisted signal transduction system.
Neoplasms
A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer.
Neoplasms
A novel signal-off photoelectrochemical biosensor for M.SssI MTase activity assay based on GQDs@ZIF-8 polyhedra as signal quencher.
Neoplasms
A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo.
Neoplasms
A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer.
Neoplasms
A phase 1 trial of the oral DNA methyltransferase inhibitor CC-486 and the histone deacetylase inhibitor romidepsin in advanced solid tumors.
Neoplasms
A phase I pharmacokinetic and pharmacodynamic study of the DNA methyltransferase 1 inhibitor MG98 administered twice weekly.
Neoplasms
A pilot clinical trial of oral tetrahydrouridine/decitabine for noncytotoxic epigenetic therapy of chemoresistant lymphoid malignancies.
Neoplasms
A potential role for epigenetic modulatory drugs in the enhancement of cancer/germ-line antigen vaccine efficacy.
Neoplasms
A Potential Role for Epigenetic Modulatory Drugs in the Enhancement of Cancer/Germ-Line Antigen Vaccine Efficacy.
Neoplasms
A prospective study of duration of smoking cessation and colorectal cancer risk by epigenetics-related tumor classification.
Neoplasms
A recombinant reporter system for monitoring reactivation of an endogenously DNA hypermethylated gene.
Neoplasms
A regulatory circuit composed of DNA methyltransferases and receptor tyrosine kinases controls lung cancer cell aggressiveness.
Neoplasms
A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1.
Neoplasms
A robust and rapid liquid chromatography tandem mass spectrometric method for the quantitative analysis of 5-azacytidine.
Neoplasms
A signal-on fluorescence based biosensing platform for highly sensitive detection of DNA methyltransferase enzyme activity and inhibition.
Neoplasms
A STUDY OF THE RELATIONSHIP BETWEEN LEVELS OF METHYLTRANSFERASES IN PERIPHERAL BLOOD MONONUCLEAR CELLS AND CHARACTERISTICS OF TUMOR IN PATIENTS WITH DUCTAL INVASIVE CARCINOMA OF BREAST.
Neoplasms
A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor.
Neoplasms
A superstructure-based electrochemical assay for signal-amplified detection of DNA methyltransferase activity.
Neoplasms
A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers.
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Aberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice.
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Aberrant DNA methylation-induced gene inactivation is associated with the diagnosis and/or therapy of T-cell leukemias.
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Aberrant DNA methyltransferase 1 expression in clear cell renal cell carcinoma development and progression.
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Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein.
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Aberrant Epigenetic Modifications of LPHN2 Function as a Potential Cisplatin-specific Biomarker for Human Gastrointestinal Cancer.
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Aberrant Methylation-Mediated Silencing of lncRNA MEG3 Functions as a ceRNA in Esophageal Cancer.
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Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis.
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Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing.
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Absence of DICER1, CTCF, RPL22, DNMT3A, TRRAP, IDH1 and IDH2 hotspot mutations in patients with various subtypes of ovarian carcinomas.
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Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.
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Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications.
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Activated leukocyte cell adhesion molecule is expressed in neuroepithelial neoplasms and decreases with tumor malignancy, matrix metalloproteinase 2 expression, and absence of IDH1R132H mutation.
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Activated MEK/ERK Pathway Drives Widespread and Coordinated Overexpression of UHRF1 and DNMT1 in Cancer cells.
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Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice.
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Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma.
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Activation of DNA methyltransferase 1 by EBV LMP1 Involves c-Jun NH(2)-terminal kinase signaling.
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Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.
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Activation of silenced tumor suppressor genes in prostate cancer cells by a novel energy restriction-mimetic agent.
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Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine.
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Acute myeloid leukaemia in a case with Tatton-Brown-Rahman syndrome: the peculiar DNMT3A R882 mutation.
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ADAMTS8 is frequently down-regulated in colorectal cancer and functions as a tumor suppressor.
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Administration of metformin alleviates atherosclerosis by promoting H2S production via regulating CSE expression.
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Adoptive transfer of immature myeloid cells lacking NF-?B p50 (p50-IMC) impedes the growth of MHC-matched high-risk neuroblastoma.
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AID assists DNMT1 to attenuate BCL6 expression through DNA methylation in diffuse large B-cell lymphoma cell lines.
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AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine.
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Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer.
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Alterations of DNA methylation and clinicopathological diversity of human cancers.
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Altered DNA methyltransferases promoter methylation and mRNA expression are associated with tamoxifen response in breast tumors.
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An Effective Epigenetic-PARP inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA-mutations.
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An epigenetic regulator-related score (EpiScore) predicts survival in patients with diffuse large B cell lymphoma and identifies patients who may benefit from epigenetic therapy.
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An essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas.
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An integrated epigenetic and genetic analysis of DNA methyltransferase genes (DNMTs) in tumor resistant and susceptible chicken lines.
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An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes.
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Analysis of the PD-1 Ligands Among Gastrointestinal Cancer Patients: Focus on Cancer Immunity.
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Anti-invasive effects of decitabine, a DNA methyltransferase inhibitor, through tightening of tight junctions and inhibition of matrix metalloproteinase activities in AGS human gastric carcinoma cells.
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Anti-neoplastic and demethylating activity of a newly synthetized flavanone-derived compound in Renal Cell Carcinoma cell lines.
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Anticancer drugs induce hypomethylation of the acetylcholinesterase promoter via a phosphorylated-p38-DNMT1-AChE pathway in apoptotic hepatocellular carcinoma cells.
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Anticancer potential of naturally occurring immunoepigenetic modulators: A promising avenue?
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Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation.
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Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential.
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Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes.
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Application of mRNA regulatory regions to improve tumor specificity of transgene expression.
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Array-based approaches for the identification of epigenetic silenced tumor suppressor genes.
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Artesunate Suppresses the Growth of Prostatic Cancer Cells through Inhibiting Androgen Receptor.
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Association between serum concentrations of perfluoroalkyl substances (PFAS) and expression of serum microRNAs in a cohort highly exposed to PFAS from drinking water.
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Association of DNMT1 gene polymorphisms in exons with sporadic infiltrating ductal breast carcinoma among chinese han women in the Heilongjiang province.
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Association of DNMT3B -283 T > C and -579 G > T polymorphisms with decreased cancer risk: evidence from a meta-analysis.
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Association of five genetic variations in DNMT1 and DNMT3A with gastric cancer in a Chinese population.
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Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan.
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Association of Polymorphisms in Genes Involved in One-Carbon Metabolism with MTHFR Methylation Levels.
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ATDC/TRIM29 Drives Invasive Bladder Cancer Formation through miRNA-Mediated and Epigenetic Mechanisms.
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Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives.
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Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines.
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Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines.
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Beyond regulations at DNA levels: A review of epigenetic therapeutics targeting cancer stem cells.
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Bile Acid Tethered Docetaxel-Based Nanomicelles Mitigate Tumor Progression through Epigenetic Changes.
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Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs.
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Biodistribution, tumor detection and radiation dosimetry of F-18 5-Fluoro-2'-Deoxycytidine (18F-FdCyd) with Tetrahydrouridine in solid tumors.
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Bioinformatics Analysis Identifies Key Genes and Pathways in Acute Myeloid Leukemia Associated with DNMT3A Mutation.
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Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis.
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Biological and clinical influences of NPM1 in acute myeloid leukemia patients with DNMT3A mutations.
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Biological functions of DNA methyltransferase 1 require its methyltransferase activity.
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Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation.
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Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells.
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Blastic plasmacytoid dendritic cell neoplasm with unusual morphology, MYC rearrangement and TET2 and DNMT3A mutations.
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Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia.
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BRD4 associates with p53 in DNMT3A-mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor JQ1.
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Cancer cells escape p53's tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation.
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Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells.
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CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML.
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CDKN2B downregulation and other genetic characteristics in T-acute lymphoblastic leukemia.
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Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line.
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Centchroman altered the expressions of tumor-related genes through active chromatin modifications in mammary cancer.
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Changes in de novo DNA (cytosine-5-)-methyltransferase activity in oncogenically susceptible rat target tissues induced by N-methyl-N-nitrosourea.
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Changes in methyl-sensitive restriction sites of liver DNA from hamsters chronically exposed to hydrazine sulfate.
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Characterization of decomposition products and preclinical and low dose clinical pharmacokinetics of decitabine (5-aza-2'-deoxycytidine) by a new liquid chromatography/tandem mass spectrometry quantification method.
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Characterization of gene mutations and copy number changes in acute myeloid leukemia using a rapid target enrichment protocol.
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Chemoproteomics-Enabled Discovery of a Potent and Selective Inhibitor of the DNA Repair Protein MGMT.
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Chicken or Egg: Is Clonal Hematopoiesis Primarily Caused by Genetic or Epigenetic Aberrations?
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Chinese herbal medicine Xiaoji decoction inhibited growth of lung cancer cells through AMPK?-mediated inhibition of Sp1 and DNA methyltransferase 1.
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Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation.
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Chlorogenic Acid Decreases Malignant Characteristics of Hepatocellular Carcinoma Cells by Inhibiting DNMT1 Expression.
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circ0093740 Promotes Tumor Growth and Metastasis by Sponging miR-136/145 and Upregulating DNMT3A in Wilms Tumor.
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Clinical and biological implications of IDH1/2 in acute myeloid leukemia with DNMT3Amut.
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Clinical and prognosis value of the CIMP status combined with MLH1 or p16 (INK4a) methylation in colorectal cancer.
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Clinical Effect of Combined Mutations in DNMT3A, FLT3-ITD, and NPM1 Among Egyptian Acute Myeloid Leukemia Patients.
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Clinical molecular testing for ASXL1 c.1934dupG p.Gly646fs mutation in hematologic neoplasms in the NGS era.
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Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer.
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Clinicopathologic significance of DNA methyltransferase 1, 3a, and 3b overexpression in Tunisian breast cancers.
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Clinicopathological significance and prognostic value of DNA methyltransferase 1, 3a, and 3b expressions in sporadic epithelial ovarian cancer.
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Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells.
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Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms.
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Clonal hematopoiesis of indeterminate potential-associated mutations and risk of comorbidities in patients with myelodysplastic syndrome.
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Clonal Hematopoiesis of Indeterminate Potential: A Multidisciplinary Challenge in Personalized Hematology.
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CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity.
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Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3.
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Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies.
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Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells.
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Combination of selenium and green tea improves the efficacy of chemoprevention in a rat colorectal cancer model by modulating genetic and epigenetic biomarkers.
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Combination therapy with epigenetic-targeted and chemotherapeutic drugs delivered by nanoparticles to enhance the chemotherapy response and overcome resistance by breast cancer stem cells.
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Combination treatment with doxorubicin and microRNA-21 inhibitor synergistically augments anticancer activity through upregulation of tumor suppressing genes.
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Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms.
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Combined inhibition of JAK1/2 and DNMT1 by newly identified small-molecule compounds synergistically suppresses the survival and proliferation of cervical cancer cells.
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Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer.
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Commercial glucometer as signal transducer for simple evaluation of DNA methyltransferase activity and inhibitors screening.
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Comparison of O-6-methylguanine DNA methyltransferase (MGMT) mRNA levels in Mer+ and Mer- human tumor cell lines containing the MGMT gene by the polymerase chain reaction technique.
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Comparison of p16(INK4a) expression with p53 alterations in head and neck cancer by tissue microarray analysis.
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Comparison of the effects of olsalazine and decitabine on the expression of CDH1 and uPA genes and cytotoxicity in MDA-MB-231 breast cancer cells.
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Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells.
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Computational fishing of new DNA methyltransferase inhibitors from natural products.
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Concurrent mutations in other epigenetic modulators portend better prognosis in BCOR-mutated myelodysplastic syndrome.
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Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1.
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Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2'-deoxycytidine in human leukemic KG1 cells.
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Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A.
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Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing.
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Cooperative DNA binding and protein/DNA fiber formation increases the activity of the Dnmt3a DNA methyltransferase.
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Coordinate regulation of microenvironmental stimuli and role of methylation in bone metastasis from breast carcinoma.
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Correlations among PPAR?, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer.
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Correlative Analysis of DNA Methyltransferase Expression and Promoter Hypermethylation of Tumor Suppressor Genes in Hepatocellular Carcinoma.
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Coupling hybridization chain reaction with DNAzyme recycling for enzyme-free and dual amplified sensitive fluorescent detection of methyltransferase activity.
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CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.
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CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas.
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Critical role of deltaDNMT3B4/2 in regulating RASSF1A promoter-specific DNA methylation in non-small cell lung cancer.
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Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells.
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Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis.
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Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.
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Cytosine-5 methylation-directed construction of a Au nanoparticle-based nanosensor for simultaneous detection of multiple DNA methyltransferases at the single-molecule level.
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dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes.
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De novo DNA methyltransferase DNMT3A: Regulation of oligomeric state and mechanism of action in response to pH changes.
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De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine.
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De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase.
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De novo methyltransferases: Potential players in diseases and new directions for targeted therapy.
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Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy.
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Decitabine Augments Chemotherapy-Induced PD-L1 Upregulation for PD-L1 Blockade in Colorectal Cancer.
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Decitabine effect on tumor global DNA methylation and other parameters in a phase I trial in refractory solid tumors and lymphomas.
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Decitabine inhibits the cell growth of cholangiocarcinoma in cultured cell lines and mouse xenografts.
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Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation.
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Decitabine, differently from DNMT1 silencing, exerts its antiproliferative activity through p21 upregulation in malignant pleural mesothelioma (MPM) cells.
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Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma.
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Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation.
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Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
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Deep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dysregulation of epithelial-mesenchymal transition and subcellular re-localization of Beta-Catenin.
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Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.
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Delivery of 5-Azacytidine to Human Cancer Cells by Elaidic Acid Esterification Increases Therapeutic Drug Efficacy.
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Demethylation of a LINE-1 antisense promoter in the cMet locus impairs Met signalling through induction of illegitimate transcription.
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Deoxyribonucleic acid methyltransferase 3B promotes epigenetic silencing through histone 3 chromatin modifications in pituitary cells.
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Depleting long noncoding RNA HOTAIR attenuates chronic myelocytic leukemia progression by binding to DNA methyltransferase 1 and inhibiting PTEN gene promoter methylation.
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Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells.
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Depletion of DNMT1 in differentiated human cells highlights key classes of sensitive genes and an interplay with polycomb repression.
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Depletion of ZBTB38 potentiates the effects of DNA demethylating agents in cancer cells via CDKN1C mRNA up-regulation.
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Deregulation of DNMT1, DNMT3B and miR29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis.
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Detection of the level of DNMT1 based on self-assembled probe signal amplification technique in plasma.
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Developmental DNA methyltransferase inhibitors in the treatment of gynecologic cancers.
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Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer.
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Dietary selenite and azadeoxycytidine treatments affect dimethylhydrazine-induced aberrant crypt formation in rat colon and DNA methylation in HT-29 cells.
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Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer.
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Differential expression of DNA-methyltransferases in drug resistant murine neuroblastoma cells.
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Differential expression of the epigenetic methylation-related protein DNMT1 by breast cancer molecular subtype and stromal histology.
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Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2'-Deoxycytidine in Solid Tumor Cells.
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Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells.
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Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation.
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Direct monitoring of breast and endometrial cancer cell epigenetic response to DNA methyltransferase and histone deacetylase inhibitors.
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Disruption of DNA methylation via S-adenosylhomocysteine is a key process in high incidence liver carcinogenesis in fish.
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Distinct clinical and biological implications of various DNMT3A mutations in myeloid neoplasms.
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Distinct demographic profile and molecular markers of primary CNS tumor in 1873 adolescent and young adult patient population.
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DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers.
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DNA damage response as a prognostic indicator in metastatic breast cancer via mutational analysis.
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DNA demethylating agents and histone deacetylase inhibitors in hematologic malignancies.
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DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines.
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DNA Electrochemistry Shows DNMT1 Methyltransferase Hyperactivity in Colorectal Tumors.
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DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.
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DNA Hypermethylation Involves in the Down-Regulation of Chloride Intracellular Channel 4 (CLIC4) Induced by Photodynamic Therapy.
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DNA hypermethylation of myeloid cells, a novel therapeutic target in MDS and AML.
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DNA Methyl Transferase 1 Reduces Expression of SRD5A2 in the Aging Adult Prostate.
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DNA methyl transferase 1: regulatory mechanisms and implications in health and disease.
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DNA methylation and methylase levels in normal and malignant mouse hepatic tissues.
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DNA methylation and not H3K4 trimethylation dictates the expression status of miR-152 gene which inhibits migration of breast cancer cells via DNMT1/CDH1 loop.
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DNA methylation and targeted sequencing of methyltransferases family genes in canine acute myeloid leukaemia, modelling human myeloid leukaemia.
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DNA Methylation and the Potential Role of Methyl-Containing Nutrients in Cardiovascular Diseases.
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DNA methylation by DNMT1 and DNMT3b methyltransferases is driven by the MUC1-C oncoprotein in human carcinoma cells.
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DNA methylation changes following 5-azacitidine treatment in patients with myelodysplastic syndrome.
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DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells.
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DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.
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DNA methylation pathway alterations in an autochthonous murine model of prostate cancer.
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DNA Methylation Profile at the DNMT3L Promoter: A Potential Biomarker for Cervical Cancer.
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DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer.
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DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells.
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DNA methylation status of hMLH1, p16(INK4a), and CDH1 is not associated with mRNA expression levels of DNA methyltransferase and DNA demethylase in gastric carcinomas.
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Dna methyltransferase 1 (DNMT1) gene activity in human lymphomas correlates with aberrant p53 gene expression.
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DNA methyltransferase 1 inhibits O6-methylguanine-DNAmethyl-transferase-mediated cell growth and metastasis of hypopharyngeal squamous carcinoma.
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DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation.
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DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria.
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DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis.
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DNA Methyltransferase 1: A Potential Gene Therapy Target for Hepatocellular Carcinoma?
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DNA methyltransferase 3-like affects promoter methylation of thymine DNA glycosylase independently of DNMT1 and DNMT3B in cancer cells.
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DNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27/H3K9 methylation in EMT-related metastasis of gastric cancer.
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DNA methyltransferase 3a rs1550117 genetic polymorphism predicts poor survival in gastric cancer patients.
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DNA methyltransferase 3b (DNMT3b), tumor tissue DNA methylation, Gleason score, and prostate cancer mortality: investigating causal relationships.
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DNA methyltransferase 3B -149C/T polymorphism and the risk of laryngeal squamous cell carcinoma: a case-control study.
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DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras.
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DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma.
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DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis.
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DNA methyltransferase 3b silencing affects locus-specific DNA methylation and inhibits proliferation, migration and invasion in human hepatocellular carcinoma SMMC-7721 and BEL-7402 cells.
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DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair.
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DNA methyltransferase detection based on digestion triggering the combination of poly adenine DNA with gold nanoparticles.
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DNA methyltransferase DNMT3b protein overexpression as a prognostic factor in patients with diffuse large B-cell lymphomas.
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DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation.
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DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine.
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DNA methyltransferase expression is associated with cell proliferation in salivary mucoepidermoid carcinoma.
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DNA methyltransferase I is a mediator of doxorubicin-induced genotoxicity in human cancer cells.
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DNA methyltransferase inhibition accelerates the immunomodulation and migration of human mesenchymal stem cells.
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DNA methyltransferase inhibition increases efficacy of adoptive cellular immunotherapy of murine breast cancer.
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DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21(WAF1/CIP1/sdi1).
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DNA methyltransferase inhibition may limit cancer cell growth by disrupting ribosome biogenesis.
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DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer.
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DNA methyltransferase inhibitors and the development of epigenetic cancer therapies.
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DNA methyltransferase inhibitors and their emerging role in epigenetic therapy of cancer.
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DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application.
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DNA Methyltransferase Inhibitors Improve the Effect of Chemotherapeutic Agents in SW48 and HT-29 Colorectal Cancer Cells.
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DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies.
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DNA methyltransferase inhibitors in cancer: From pharmacology to translational studies.
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DNA Methyltransferase Inhibitors in Myeloid Cancer: Clonal Eradication or Clonal Differentiation?
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DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation.
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DNA methyltransferase inhibitors: old and new drugs for an epigenetic cancer therapy.
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DNA methyltransferase mediates the hypermethylation of the microRNA 34a promoter and enhances the resistance of patient-derived pancreatic cancer cells to molecular targeting agents.
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DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.
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DNA Methyltransferase-3a Interacts with p53 and Represses p53-Mediated Gene Expression.
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DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors.
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DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model.
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DNA methyltransferases expression in normal tissues and various human cancer cell lines, xenografts and tumors.
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DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value.
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DNA-methyltransferase 3B 39179 G > T polymorphism and risk of sporadic colorectal cancer in a subset of Iranian population.
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DNMT cooperativity--the developing links between methylation, chromatin structure and cancer.
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DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer.
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DNMT1 and DNMT3B regulate tumorigenicity of human prostate cancer cells by controlling RAD9 expression through targeted methylation.
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DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8.
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DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression.
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DNMT1 as a molecular target in a multimodality-resistant phenotype in tumor cells.
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DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications.
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DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells.
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DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.
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DNMT1 is associated with cell cycle and DNA replication gene sets in diffuse large B-cell lymphoma.
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DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.
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DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells.
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Dnmt1 links BCR-ABLp210 to epigenetic tumor stem cell priming in myeloid leukemia.
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DNMT1 maintains the methylation of miR-152-3p to regulate TMSB10 expression, thereby affecting the biological characteristics of colorectal cancer cells.
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DNMT1 mediates metabolic reprogramming induced by Epstein-Barr virus latent membrane protein 1 and reversed by grifolin in nasopharyngeal carcinoma.
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DNMT1 promotes cell proliferation via methylating hMLH1 and hMSH2 promoters in EGFR-mutated non-small cell lung cancer.
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DNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A.
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DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis.
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DNMT1, DNMT3A and DNMT3B Polymorphisms Associated With Gastric Cancer Risk: A Systematic Review and Meta-analysis.
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Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele.
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DNMT3A alterations associated with myeloid malignancies dictate differential responses to hypomethylating agents.
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DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies.
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DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells.
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DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1.2 expression in spinal cord dorsal horn.
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Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.
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DNMT3a epigenetic program regulates the HIF-2? oxygen-sensing pathway and the cellular response to hypoxia.
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Dnmt3a haploinsufficiency cooperates with oncogenic Kras to promote an early-onset T-cell acute lymphoblastic leukemia.
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DNMT3A intragenic hypomethylation is associated with adverse prognosis in acute myeloid leukemia.
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Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma.
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Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
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DNMT3A mutants provide proliferating advantage with augmentation of self-renewal activity in the pathogenesis of AML in KMT2A-PTD-positive leukemic cells.
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DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms.
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DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype.
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DNMT3A overexpression is associated with aggressive behavior and enteroblastic differentiation of gastric adenocarcinoma.
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Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.
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Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.
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DNMT3A rs36012910 A>G polymorphism and gastric cancer susceptibility in a Chinese population.
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DNMT3B -149 C>T and -579 G>T Polymorphisms and Risk of Gastric and Colorectal Cancer: a Meta-analysis.
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DNMT3b -149C/T promoter variants and methylation of colorectal cancer-associated genes.
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DNMT3B -579 G>T promoter polymorphism and risk of gallbladder carcinoma in North Indian population.
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DNMT3B -579 G>T Promoter Polymorphism and the Risk of Gastric Cancer in the West of Iran.
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DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.
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Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling.
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DNMT3B Expression Might Contribute to Abnormal Methylation of RASSF1A in Lager Colorectal Adenomatous Polyps.
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DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.
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DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation.
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Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.
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DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR.
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DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation.
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DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation.
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DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer.
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DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines.
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DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma.
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DNMT3B polymorphisms and cancer risk: a meta analysis of 24 case-control studies.
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Dnmt3b Prefers Germ Line Genes and Centromeric Regions: Lessons from the ICF Syndrome and Cancer and Implications for Diseases.
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DNMT3B promoter polymorphisms and maternal risk of birth of a child with Down syndrome.
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DNMT3B7 expression promotes tumor progression to a more aggressive phenotype in breast cancer cells.
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DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.
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DNMT3L enables accumulation and inheritance of epimutations in transgenic Drosophila.
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DNMTs inhibitor SGI-1027 induces apoptosis in Huh7 human hepatocellular carcinoma cells.
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Docking of a novel DNA methyltransferase inhibitor identified from high-throughput screening: insights to unveil inhibitors in chemical databases.
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Does Wnt/?-catenin pathway contribute to the stability of DNMT1 expression in urological cancer cell lines?
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Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite.
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Down expression of lnc-BMP1-1 decreases that of Caveolin-1 is associated with the lung cancer susceptibility and cigarette smoking history.
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Down-regulated lncRNA DLX6-AS1 inhibits tumorigenesis through STAT3 signaling pathway by suppressing CADM1 promoter methylation in liver cancer stem cells.
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Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties.
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Downregulation of miR-152 contributes to DNMT1-mediated silencing of SOCS3/SHP-1 in non-Hodgkin lymphoma.
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Downregulation of miR-217 correlates with resistance of ph(+) leukemia cells to ABL tyrosine kinase inhibitors.
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Dual-signal ratiometric electrochemiluminescence assay for detecting the activity of human methyltransferase.
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Dynamic silencing of somatic L1 retrotransposon insertions reflects the developmental and cellular contexts of their genomic integration.
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Dysregulation of microRNA expression drives aberrant DNA hypermethylation in basal-like breast cancer.
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Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer.
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Dysregulation of the epigenome in human breast cancer: contributions of gene-specific DNA hypermethylation to breast cancer pathobiology and targeting the breast cancer methylome for improved therapy.
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E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines.
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Ectopic expression of activation-induced cytidine deaminase caused by epigenetics modification.
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Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival.
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Effect of antisense DNMT3b gene eukaryotic expression plasmid on expression of the DNMT3b gene in human biliary tract carcinoma cells.
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Effect of BIX-01294 on proliferation, apoptosis and histone methylation of acute T lymphoblastic leukemia cells.
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Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review.
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Effect of DNA-binding drugs on the activity of DNA methylase from Ehrlich's ascites tumour cells.
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Effect of in ovo feeding of vitamin C on antioxidation and immune function of broiler chickens.
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Effect of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring.
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Effect of mitogenic stimulation and DNA methylation on human T cell DNA methyltransferase expression and activity.
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Effects of 5-aza-2'deoxycytidine on RECK gene expression and tumor invasion in salivary adenoid cystic carcinoma.
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Effects of 5-Aza-CdR on the proliferation of human breast cancer cell line MCF-7 and on the expression of Apaf-1 gene.
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Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation.
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Effects of DNA methyltransferase 1 inhibition on esophageal squamous cell carcinoma.
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Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells.
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Effects of Propolis and Phenolic Acids on Triple-Negative Breast Cancer Cell Lines: Potential Involvement of Epigenetic Mechanisms.
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Effects of Zebularine on Invasion Activity and Intracellular Expression Level of let-7b in Colorectal Cancer Cells.
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Effects on biological behavior of bladder carcinoma T24 cells via silencing DNMT1 and/or DNMT3b with shRNA In Vitro.
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Efficacy and tolerability of temozolomide in an alternating weekly regimen in patients with recurrent glioma.
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Efficacy of decitabine-loaded nanogels in overcoming cancer drug resistance is mediated via sustained DNA methyltransferase 1 (DNMT1) depletion.
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Elevated expression and altered pattern of activity of DNA methyltransferase in liver tumors of rats fed methyl-deficient diets.
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Eliminating epigenetic barriers induces transient hormone-regulated gene expression in estrogen receptor negative breast cancer cells.
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Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.
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Enhanced anticancer effects of a methylation inhibitor by inhibiting a novel DNMT1 target, CEP 131, in cervical cancer.
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Enhanced growth inhibition by combined DNA methylation/HDAC inhibitors in lung tumor cells with silenced CDKN2A.
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Enhancement of chemotherapeutic efficacy in hypermethylator breast cancer cells through targeted and pharmacologic inhibition of DNMT3b.
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Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors.
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Enigmatic Ladies of the Rings: How Cohesin Dysfunction Affects Myeloid Neoplasms Insurgence.
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Epidrug Modulated Expression of MiR--152 and MiR-148a Reverse Cisplatin Resistance in Ovarian Cancer Cells: An Experimental In-vitro Study.
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Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways.
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Epigallocatechin gallate inhibits the growth and promotes the apoptosis of bladder cancer cells.
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Epigallocatechin-3-gallate inhibits homocysteine-induced apoptosis of endothelial cells by demethylation of the DDAH2 gene.
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Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1.
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Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment.
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Epigenetic approaches for chemosensitization of refractory diffuse large B-cell lymphomas.
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Epigenetic Aspects on Therapy Development for Gastroenteropancreatic Neuroendocrine Tumors.
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Epigenetic changes by zebularine leading to enhanced differentiation of human promyelocytic leukemia NB4 and KG1 cells.
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Epigenetic control of Foxp3 in intratumoral T-cells regulates growth of hepatocellular carcinoma.
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Epigenetic DNA methylation in radiation biology: on the field or on the sidelines?
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Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis.
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Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours.
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Epigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma.
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Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer.
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Epigenetic mechanisms in cancer: push and pull between kneaded erasers and fate writers.
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Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy.
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Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome.
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Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines.
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Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+T cells against esophageal carcinoma.
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Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity.
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Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates ?? T cell-mediated cytotoxicity in lung cancer.
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Epigenetic Modulators as Potential Multi-targeted Drugs Against Hedgehog Pathway for Treatment of Cancer.
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Epigenetic modulators hydralazine and sodium valproate act synergistically in VEGI-mediated anti-angiogenesis and VEGF interference in human osteosarcoma and vascular endothelial cells.
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Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.
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Epigenetic regulation by decitabine of melanoma differentiation in vitro and in vivo.
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Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention.
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Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma.
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Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia.
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Epigenetic regulation of glycosylation and the impact on chemo-resistance in breast and ovarian cancer.
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Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins.
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Epigenetic regulation of X-linked cancer/germline antigen genes by DNMT1 and DNMT3b.
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Epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses.
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Epigenetic silencing of miR-342-3p in B cell lymphoma and its impact on autophagy.
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Epigenetic silencing of SFRP1 and SFRP5 by Hepatitis B Virus X protein enhances hepatoma cell tumorigenicity through wnt signaling pathway.
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Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy.
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Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression.
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Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition.
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Epigenetic therapies in patients with solid tumors: Focus on monotherapy with deoxyribonucleic acid methyltransferase inhibitors and histone deacetylase inhibitors.
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Epigenetic therapy in cancer: molecular background and clinical development of histone deacetylase and DNA methyltransferase inhibitors.
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Epigenetic Up-regulation of Gene Expression in KAS 6/1 Human Multiple Myeloma Cells.
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Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma.
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Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches.
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Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
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Epigenomic reactivation screening to identify genes silenced by DNA hypermethylation in human cancer.
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Erratum to: A Comparative Study on the In Vitro Effects of the DNA Methyltransferase Inhibitor 5-Azacytidine (5-AzaC) in Breast/Mammary Cancer of Different Mammalian Species.
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Erratum to: DNMT3B polymorphisms and cancer risk: a meta analysis of 24 case-control studies.
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Erratum: Increased DNA methyltransferase expression in rhabdomyosarcomas. Int. J. Cancer, 83, 10-14 (1999).
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Essential role of DNA methyltransferase 1-mediated transcription of insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors.
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Establishment and functional validation of a structural homology model for human DNA methyltransferase 1.
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Estrogen-induced hypomethylation and overexpression of YAP1 facilitate breast cancer cell growth and survival.
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Evaluation of MUC1-Aptamer Functionalized Hybrid Nanoparticles for Targeted Delivery of miRNA-29b to Nonsmall Cell Lung Cancer.
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Evaluation of noncytotoxic DNMT1-depleting therapy in patients with myelodysplastic syndromes.
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Evidence that tumor necrosis factor-related apoptosis-inducing ligand induction by 5-Aza-2'-deoxycytidine sensitizes human breast cancer cells to adriamycin.
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Evodiamine, a Novel NOTCH3 Methylation Stimulator, Significantly Suppresses Lung Carcinogenesis in Vitro and in Vivo.
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Evolution of a contagious cancer: epigenetic variation in Devil Facial Tumour Disease.
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Examination of the DNA substrate selectivity of DNA cytosine methyltransferases using mass tagging.
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Exceptionally high protection of photocarcinogenesis by topical application of (--)-epigallocatechin-3-gallate in hydrophilic cream in SKH-1 hairless mouse model: relationship to inhibition of UVB-induced global DNA hypomethylation.
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Exome sequencing reveals DNMT3A and ASXL1 variants associate with progression of chronic myeloid leukemia after tyrosine kinase inhibitor therapy.
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Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas.
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Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer.
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Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.
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Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis.
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Expression of DNA Methyltransferase 1 Is a Hallmark of Melanoma, Correlating with Proliferation and Response to B-Raf and Mitogen-Activated Protein Kinase Inhibition in Melanocytic Tumors.
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Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer.
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Expression of human DNA methyltransferase 1 in colorectal cancer tissues and their corresponding distant normal tissues.
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Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer.
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Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis.
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Expression of O(6) -methylguanine DNA methyltransferase (MGMT) and immunohistochemical analysis of 12 pineal parenchymal tumors.
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Expression of O(6)-methylguanine DNA methyltransferase (MGMT) and its clinical significance in gastroenteropancreatic neuroendocrine neoplasm.
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Expression of prokaryotic HhaI DNA methyltransferase is transforming and lethal to NIH 3T3 cells.
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Expression of RASSF1A, an epigenetically silenced tumor suppressor, overcomes resistance to apoptosis induction by interferons.
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Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro.
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Expression of {Delta}DNMT3B Variants and Its Association with Promoter Methylation of p16 and RASSF1A in Primary Non-Small Cell Lung Cancer.
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Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma.
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Expression profiles and function of IL6 in polymorphonuclear myeloid-derived suppressor cells.
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Extended experience with a non-cytotoxic DNMT1-targeting regimen of decitabine to treat myeloid malignancies.
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EZH2 Regulates Protein Stability via Recruiting USP7 to Mediate Neuronal Gene Expression in Cancer Cells.
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Feature-based classification of amino acid substitutions outside conserved functional protein domains.
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Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A.
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Fluorescence-based Polymerase Amplification for the Sensitive Detection of DNA Methyltransferase Activity.
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FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.
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Frequent Increased Gene Copy Number and High Protein Expression of tRNA (Cytosine-5-)-Methyltransferase (NSUN2) in Human Cancers.
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FRET-Based Method for Direct, Real-Time Measurement of DNA Methyltransferase Activity.
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Function of DNA methyltransferase 3a in lead (Pb(2+) )-Induced Cyclooxygenase-2 gene.
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Function of microRNA-143 in different signal pathways in cancer: New insights into cancer therapy.
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Functional and genomic characterization of patient-derived xenograft model to study the adaptation to mTORC1 inhibitor in clear cell renal cell carcinoma.
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Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.
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Further delineation of neuropsychiatric findings in Tatton-Brown-Rahman syndrome due to disease-causing variants in DNMT3A: seven new patients.
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GAD1 Upregulation Programs Aggressive Features of Cancer Cell Metabolism in the Brain Metastatic Microenvironment.
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Gene expression and promoter polymorphisms of DNA methyltransferase 3B in nasopharyngeal carcinomas in Taiwanese people: a case-control study.
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Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis.
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Generation of antigen-presenting cells from tumor-infiltrated CD11b myeloid cells with DNA demethylating agent 5-aza-2'-deoxycytidine.
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Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer.
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Genetic and Epigenetic Perturbations by DNMT3A-R882 Mutants Impaired Apoptosis through Augmentation of PRDX2 in Myeloid Leukemia Cells.
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Genetic and epigenetic variation in the DNMT3B and MTHFR genes and colorectal adenoma risk.
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Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells.
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Genetic Polymorphism of DNA Methyltransferase 3A rs1550117 A>G and Risk of Cancer: A Meta-analysis.
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Genetic variations in epigenetic genes are predictors of recurrence in stage I or II non-small cell lung cancer patients.
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Genome-wide analysis in a murine dnmt1 knockdown model identifies epigenetically silenced genes in primary human pituitary tumors.
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Genome-wide hypomethylation in cancer may be a passive consequence of transformation.
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Genomic markers of midostaurin drug sensitivity in FLT3 mutated and FLT3 wild-type acute myeloid leukemia patients.
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Genomic profiling of well-differentiated hepatocellular neoplasms with diffuse glutamine synthetase staining reveals similar genetics across the adenoma to carcinoma spectrum.
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Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in human breast cancer.
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GLAD-PCR Assay of R(5mC)GY Sites in the Regulatory Region of Tumor-Suppressor Genes Associated with Gastric Cancer.
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Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer.
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Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis.
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Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging.
Neoplasms
Hammerhead ribozyme-mediated sensitization of human tumor cells after treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea.
Neoplasms
Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.
Neoplasms
Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.
Neoplasms
HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence.
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HDL-AuNPs-BMS Nanoparticle Conjugates as Molecularly Targeted Therapy for Leukemia.
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Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NF?B pathway in gastric cancer development.
Neoplasms
Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea.
Neoplasms
Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition.
Neoplasms
Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotype.
Neoplasms
HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.
Neoplasms
High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors.
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High DNMT1 Is Associated With Worse Local Control in Early-Stage Laryngeal Squamous Cell Carcinoma.
Neoplasms
High expression of DNA methyltransferase 1 in Kazakh esophageal epithelial cells may promote malignant transformation induced by N-methyl-N'-nitro-N-nitrosoguanidine.
Neoplasms
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.
Neoplasms
Higher methylation intensity induced by EBV LMP1 via NF-?B/ DNMT3b signaling contributes to silencing of PTEN gene.
Neoplasms
Highly sensitive photoelectrochemical assay for DNA methyltransferase activity and inhibitor screening by exciton energy transfer coupled with enzyme cleavage biosensing strategy.
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Histone Deacetylase Inhibitors Reverse CpG Methylation by Regulating DNMT1 through ERK Signaling.
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hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing.
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Homology modeling, docking and structure-based pharmacophore of inhibitors of DNA methyltransferase.
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Hormonal therapy promotes hormone-resistant phenotype by increasing DNMT activity and expression in prostate cancer models.
Neoplasms
HOTAIR Induces Methylation of PCDH10, a Tumor Suppressor Gene, by Regulating DNMT1 and Sponging with miR-148b in Gastric Adenocarcinoma.
Neoplasms
HOTAIR-mediated reciprocal regulation of EZH2 and DNMT1 contribute to polyphyllin I-inhibited growth of castration-resistant prostate cancer cells in vitro and in vivo.
Neoplasms
HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors.
Neoplasms
Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation.
Neoplasms
Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern.
Neoplasms
Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways.
Neoplasms
Human papillomavirus type 16 E6 suppresses microRNA-23b expression in human cervical cancer cells through DNA methylation of the host gene C9orf3.
Neoplasms
Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway.
Neoplasms
Hyaluronan-CD44v3 interaction with Oct4/Sox2/Nanog promotes miR-302 expression leading to self-renewal, clonal formation and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma.
Neoplasms
Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice.
Neoplasms
Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.
Neoplasms
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma.
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Hypermethylation of the progesterone receptor A in constitutive antiprogestin-resistant mouse mammary carcinomas.
Neoplasms
Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.
Neoplasms
Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells.
Neoplasms
Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells.
Neoplasms
Identification and validation of mRNA 3'untranslated regions of DNMT3B and TET3 as novel competing endogenous RNAs of the tumor suppressor PTEN.
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Identification of a novel leukemic-specific splice variant of DNMT3B and its stability.
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Identification of clinical trait-related lncRNA and mRNA biomarkers with weighted gene co-expression network analysis as useful tool for personalized medicine in ovarian cancer.
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Identification of DBCCR1 as a suppressor in the development of lung cancer that is associated with increased DNA methyltransferase 1.
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Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival.
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Identification of DNMT1 selective antagonists using a novel scintillation proximity assay.
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Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer.
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Identification of key genes by integrating DNA methylation and next-generation transcriptome sequencing for esophageal squamous cell carcinoma.
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Identification of novel DNA methylation inhibitors via a two-component reporter gene system.
Neoplasms
Identification of potent inhibitors of DNA methyltransferase 1 (DNMT1) through a pharmacophore-based virtual screening approach.
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Identification of putative targets of DNA (cytosine-5) methylation-mediated transcriptional silencing using a novel conditionally active form of DNA methyltransferase 3a.
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Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening.
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IFN-? potentiates the direct and immune-mediated antitumor effects of epigenetic drugs on both metastatic and stem cells of colorectal cancer.
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IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation.
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Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers.
Neoplasms
Immunocytochemical staining of different cell types in vaginal smears by monoclonal anti-DNA methylase antibodies.
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Immunohistochemical analysis of polycomb group protein expression in advanced gastric cancer.
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Immunohistochemical analysis of the DNA methyltransferase 3b expression is associated with significant improvements in the discrimination of ulcerative colitis-associated neoplastic lesions.
Neoplasms
Immunohistochemical evaluation of Klotho and DNA methyltransferase 3a in oral squamous cell carcinomas.
Neoplasms
Immunohistochemical evaluation of O(6) -methylguanine DNA methyltransferase (MGMT) expression in 117 cases of glioblastoma.
Neoplasms
Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas.
Neoplasms
Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status.
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Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.
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Impact on DNA Methylation in Cancer Prevention and Therapy by Bioactive Dietary Components.
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In silico docking of methyl isocyanate (MIC) and its hydrolytic product (1, 3-dimethylurea) shows significant interaction with DNA Methyltransferase 1 suggests cancer risk in Bhopal-Gas- Tragedy survivors.
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Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review.
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Incorporation of mutations in five genes in the revised International Prognostic Scoring System can improve risk stratification in the patients with myelodysplastic syndrome.
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Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.
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Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers.
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Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas.
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Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder.
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Increased expression of deoxyribonucleic acid methyltransferase gene in human astrocytic tumors.
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Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion.
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Increased Expression of DNA Methyltransferase 3a in Obese Adipose Tissue: Studies With Transgenic Mice.
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Increased expression of DNA methyltransferase-1 in non-neoplastic epithelium helps predict colorectal neoplasia risk in ulcerative colitis.
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Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas.
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Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer.
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Indirubin regulates MPL and TNF expression in peripheral blood mononuclear cells from patients with primary immune thrombocytopenia.
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Induction of active demethylation and 5hmC formation by 5-azacytidine is TET2 dependent and suggests new treatment strategies against hepatocellular carcinoma.
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Induction of DNMT3B by PGE2 and IL6 at Distant Metastatic Sites Promotes Epigenetic Modification and Breast Cancer Colonization.
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Influence of Histone Deacetylase Inhibitors and DNA-Methyltransferase Inhibitors on the NK Cell-Mediated Lysis of Pediatric B-Lineage Leukemia.
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Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.
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Inhibition of de novo Methyltransferase 3B is a Potential Therapy for Hepatocellular Carcinoma.
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Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer.
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Inhibition of DNA methylation by antisense oligonucleotide MG98 as cancer therapy.
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Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response.
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Inhibition of DNA methyltransferase 1 by RNA interference reverses epithelial-mesenchymal transition in highly metastatic 95D lung cancer cells by inhibiting the Wnt signaling pathway.
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Inhibition of DNA methyltransferase activates tumor necrosis factor alpha-induced monocytic differentiation in acute myeloid leukemia cells.
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Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
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Inhibition of DNA methyltransferase as a novel therapeutic strategy to overcome acquired resistance to dual PI3K/mTOR inhibitors.
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Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signaling.
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Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling.
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Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells.
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Inhibition of EZH2 via activation of SAPK/JNK and reduction of p65 and DNMT1 as a novel mechanism in inhibition of human lung cancer cells by polyphyllin I.
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Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2'-deoxycytidine treatment.
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Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a.
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Inhibition of p53 represses E-cadherin expression by increasing DNA methyltransferase-1 and promoter methylation in serous borderline ovarian tumor cells.
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Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells.
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Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy.
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Insulin-like growth factor binding protein-3 (IGFBP-3) plays a role in the anti-tumorigenic effects of 5-Aza-2'-deoxycytidine (AZA) in breast cancer cells.
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Integrative Analysis Reveals Comprehensive Altered Metabolic Genes Linking with Tumor Epigenetics Modification in Pan-Cancer.
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Interplay of DNA methyltransferase 1 and EZH2 through inactivation of Stat3 contributes to ?-elemene-inhibited growth of nasopharyngeal carcinoma cells.
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Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
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Intravenous 5-fluoro-2'-deoxycytidine administered with tetrahydrouridine increases the proportion of p16-expressing circulating tumor cells in patients with advanced solid tumors.
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Invasive and Noninvasive Nonfunctioning Gonadotroph Pituitary Tumors Differ in DNA Methylation Level of LINE-1 Repetitive Elements.
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Investigation of GSTP1 and epigenetic regulators expression pattern in a population of Iranian patient with prostate cancer.
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Investigation of the expression patterns and correlation of DNA methyltransferases and class I histone deacetylases in ovarian cancer tissues.
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Involvement of epigenetics and microRNA-29b in the urethane induced inception and establishment of mouse lung tumors.
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Is the Proteome of Bronchoalveolar Lavage Extracellular Vesicles a Marker of Advanced Lung Cancer?
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Ischemia dysregulates DNA methyltransferases and p16(INK4a) methylation in human colorectal cancer cells.
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Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas.
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Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery.
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Isovitexin Suppresses Cancer Stemness Property And Induces Apoptosis Of Osteosarcoma Cells By Disruption Of The DNMT1/miR-34a/Bcl-2 Axis.
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JAK2 regulates mismatch repair protein-mediated epigenetic alterations in response to oxidative damage.
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Kindlin-2 interacts with and stabilizes DNMT1 to promote breast cancer development.
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Knockdown of DNA methyltransferase-1 inhibits proliferation and derepresses tumor suppressor genes in myeloma cells.
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KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGF?1 Activation.
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Kruppel-Like Factor 9 Loss-of-Expression in Human Endometrial Carcinoma Links Altered Expression of Growth-Regulatory Genes with Aberrant Proliferative Response to Estrogen.
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Label-free fluorescence detection of DNA methylation and methyltransferase activity based on restriction endonuclease HpaII and exonuclease III.
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Label-free fluorescence strategy for methyltransferase activity assay based on poly-thymine copper nanoclusters engineered by terminal deoxynucleotidyl transferase.
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Laccaic Acid A Is a Direct, DNA-competitive Inhibitor of DNA Methyltransferase 1.
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Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer.
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Lactate-fueled oxidative metabolism drives DNA methyltransferase 1-mediated transcriptional co-activator with PDZ binding domain protein activation.
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Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine.
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Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation.
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LINC00337 promotes tumor angiogenesis in colorectal cancer by recruiting DNMT1, which suppresses the expression of CNN1.
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LncRNA NEAT1 Interacted With DNMT1 to Regulate Malignant Phenotype of Cancer Cell and Cytotoxic T Cell Infiltration via Epigenetic Inhibition of p53, cGAS, and STING in Lung Cancer.
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LncRNATCF7 up-regulates DNMT1 mediated by HPV-18 E6 and regulates biological behavior of cervical cancer cells by inhibiting miR-155.
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Long non-coding RNA DBCCR1-003 regulate the expression of DBCCR1 via DNMT1 in bladder cancer.
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Long noncoding RNA NEAT1 promotes progression of glioma as a ceRNA by sponging miR-185-5p to stimulate DNMT1/mTOR signaling.
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Long term transcriptional reactivation of epigenetically silenced genes in colorectal cancer cells requires DNA hypomethylation and histone acetylation.
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Long-term cadmium exposure leads to the enhancement of lymphocyte proliferation via down-regulating p16 by DNA hypermethylation.
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Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy.
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Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation.
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Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-?.
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Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis.
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Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis.
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Loss of exosomal miR-148b from cancer-associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis.
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Loss of pericentromeric DNA methylation pattern in human glioblastoma is associated with altered DNA methyltransferases expression and involves the stem cell compartment.
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Loss of post-transcriptional regulation of DNMT3b by microRNAs: a possible molecular mechanism for the hypermethylation defect observed in a subset of breast cancer cell lines.
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Loss of RB compromises specific heterochromatin modifications and modulates HP1alpha dynamics.
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Low expression of PRKCDBP promoted cisplatin resistance in lung adenocarcinoma by DNMT1 and TNF??.
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Lower expression of p14ARF and p16INK4a correlates with higher DNMT3B expression in human oesophageal squamous cell carcinomas.
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LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer.
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m5C RNA Methylation Primarily Affects the ErbB and PI3K-Akt Signaling Pathways in Gastrointestinal Cancer.
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Magnetic bead-liposome hybrids enable sensitive and portable detection of DNA methyltransferase activity using personal glucose meter.
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Magnetic immunoassay using CdSe/ZnS quantum dots as fluorescent probes to detect the level of DNA methyltransferase 1 in human serum sample.
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Maintenance Therapy with Decitabine after Allogeneic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplastic Syndrome.
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Maternal nicotinamide supplementation causes global DNA hypomethylation, uracil hypo-incorporation and gene expression changes in fetal rats.
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MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome.
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Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis.
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Messenger RNA expression and methylation of candidate tumor-suppressor genes and risk of ovarian cancer-a case-control analysis.
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Meta-analysis Reveals No Association of DNMT3B -149 C>T Gene Polymorphism With Overall Cancer Risk.
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Metastasis-associated protein 1 is an upstream regulator of DNMT3a and stimulator of insulin-growth factor binding protein-3 in breast cancer.
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Metformin selectively inhibits metastatic colorectal cancer with the KRAS mutation by intracellular accumulation through silencing MATE1.
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Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissue.
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Methylation of MGMT in malignant pleural mesothelioma occurs in a subset of patients and is associated with the T allele of the rs16906252 MGMT promoter SNP.
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Methylation of miR-124a-1, miR-124a-2, and miR-124a-3 genes correlates with aggressive and advanced breast cancer disease.
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Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.
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Methylation of the miR?29b?3p promoter contributes to angiogenesis, invasion, and migration in pancreatic cancer.
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Methylation of Wnt7a Is Modulated by DNMT1 and Cigarette Smoke Condensate in Non-Small Cell Lung Cancer.
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Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
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Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.
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Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance.
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Methyltransferase expression and tumor suppressor gene methylation in sporadic and familial colorectal cancer.
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Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
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MGMT promoter methylation is associated with temozolomide response and prolonged progression-free survival in disseminated cutaneous melanoma.
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Micro RNAs and DNA methylation are regulatory players in human cells with altered X chromosome to autosome balance.
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Microenvironment-induced downregulation of miR-193b drives ovarian cancer metastasis.
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MicroRNA -29b induces global DNA hypomethylation and tumor suppressor gene re-expression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.
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MicroRNA-129-5p inhibits human glioma cell proliferation and induces cell cycle arrest by directly targeting DNMT3A.
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MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer.
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MicroRNA-148a overexpression improves the early development of porcine somatic cell nuclear transfer embryos.
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MicroRNA-148b and microRNA-152 reactivate tumor suppressor genes through suppression of DNA methyltransferase-1 gene in pancreatic cancer cell lines.
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MicroRNA-26a inhibits proliferation and metastasis of human hepatocellular carcinoma by regulating DNMT3B-MEG3 axis.
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MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1.
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MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes.
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MiR-137 Suppresses Triple-Negative Breast Cancer Stemness and Tumorigenesis by Perturbing BCL11A-DNMT1 Interaction.
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MiR-139-5p suppresses osteosarcoma cell growth and invasion through regulating DNMT1.
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MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus.
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miR-148-3p Inhibits Growth of Glioblastoma Targeting DNA Methyltransferase-1 (DNMT1).
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miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.
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miR-148b reverses cisplatin-resistance in non-small cell cancer cells via negatively regulating DNA (cytosine-5)-methyltransferase 1(DNMT1) expression.
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MiR-152 functioning as a tumor suppressor that interacts with DNMT1 in nasopharyngeal carcinoma.
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miR-155 increases stemness and decitabine resistance in triple-negative breast cancer cells by inhibiting TSPAN5.
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miR-185 inhibits hepatocellular carcinoma growth by targeting the DNMT1/PTEN/Akt pathway.
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miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer.
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MiR-211 is epigenetically regulated by DNMT1 mediated methylation and inhibits EMT of melanoma cells by targeting RAB22A.
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miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway.
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miR-29c-3p regulates DNMT3B and LATS1 methylation to inhibit tumor progression in hepatocellular carcinoma.
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miR-29s inhibit the malignant behavior of U87MG glioblastoma cell line by targeting DNMT3A and 3B.
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MiR-339 and especially miR-766 reactivate the expression of tumor suppressor genes in colorectal cancer cell lines through DNA methyltransferase 3B gene inhibition.
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miR-373 Negatively Regulates Methyl-CpG-Binding Domain Protein 2 (MBD2) in Hilar Cholangiocarcinoma.
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MiR-377 reverses cancerous phenotypes of pancreatic cells via suppressing DNMT1 and demethylating tumor suppressor genes.
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MiR-410 is overexpressed in liver and colorectal tumors and enhances tumor cell growth by silencing FHL1 via a direct/indirect mechanism.
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MiRNA-140 acts as a liver tumor suppressor by controlling NF-?B activity via directly targeting Dnmt1 expression.
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Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells.
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Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma.
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MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes.
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Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis.
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Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine.
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Modulation of miR-203 and its regulators as a function of time during the development of 7, 12 dimethylbenz [a] anthracene induced mouse skin tumors in presence or absence of the antitumor agents.
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Molecular Characterization of a Rare Case of Bilateral Vitreoretinal T Cell Lymphoma through Vitreous Liquid Biopsy.
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Molecular pathogenesis of breast cancer: impact of miR-99a-5p and miR-99a-3p regulation on oncogenic genes.
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Mouse ascites DNA methylase: characterisation of size, proteolytic breakdown and nucleotide recognition.
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MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma.
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MUC1-C induces DNA methyltransferase 1 and represses tumor suppressor genes in acute myeloid leukemia.
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Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing.
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Multifunctional Gold Nanoparticles Overcome MicroRNA Regulatory Network Mediated-Multidrug Resistant Leukemia.
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Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood.
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Multiple sealed primers-mediated rolling circle amplification strategy for sensitive and specific detection of DNA methyltransferase activity.
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Multiproteomic and Transcriptomic Analysis of Oncogenic ?-Catenin Molecular Networks.
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Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms.
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Mutation analysis of JAK2V617F, FLT3-ITD, NPM1, and DNMT3A in Chinese patients with myeloproliferative neoplasms.
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Mutations found in cell-free DNAs of patients with malignant lymphoma at remission can derive from clonal hematopoiesis.
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Mutations in DNMT3A and loss of RKIP are independent events in acute monocytic leukemia.
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Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns.
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Mutually Exclusive Promoter Hypermethylation Patterns of hMLH1 and O6-Methylguanine DNA Methyltransferase in Colorectal Cancer.
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Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine.
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MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer.
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Myeloid malignancies with isolated 7q deletion can be further characterized by their accompanying molecular mutations.
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Nanaomycin A Selectively Inhibits DNMT3B and Reactivates Silenced Tumor Suppressor Genes in Human Cancer Cells.
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Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer.
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Neoantigen-based EpiGVAX vaccine initiates antitumor immunity in colorectal cancer.
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New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase.
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New insights into estrogenic regulation of O(6)-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-? and MGMT proteins by fulvestrant or O(6)-benzylguanine indicates fresh avenues for therapy.
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Next-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutations.
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Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats.
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NNK-induced DNA methyltransferase 1 in lung tumorigenesis in A/J mice and inhibitory effects of (-)-epigallocatechin-3-gallate.
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Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation.
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Novel Curcumin Liposome Modified with Hyaluronan Targeting CD44 Plays an Anti-Leukemic Role in Acute Myeloid Leukemia in Vitro and in Vivo.
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Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4'-thio-2'-deoxycytidine and 5-aza-4'-thio-2'-deoxycytidine.
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Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma.
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Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes.
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Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation.
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NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1.
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NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.
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NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization.
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NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia.
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NUC041, a Prodrug of the DNA Methytransferase Inhibitor 5-aza-2',2'-Difluorodeoxycytidine (NUC013), Leads to Tumor Regression in a Model of Non-Small Cell Lung Cancer.
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O(6)-Methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma.
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O(6)-methylguanine DNA methyltransferase immunoexpression in nonfunctioning pituitary adenomas: are progressive tumors potential candidates for temozolomide treatment?
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O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors.
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O6-Methylguanine DNA Methyltransferase Status Does Not Predict Response or Resistance to Alkylating Agents in Well-Differentiated Pancreatic Neuroendocrine Tumors.
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OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug.
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Oncogenic human papillomavirus imposes an instructive pattern of DNA methylation changes which parallel the natural history of cervical HPV infection in young women.
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Oncogenic nature of a novel mutant AATF and its interactome existing within human cancer cells.
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Oncogenic Roles and Inhibitors of DNMT1, DNMT3A, and DNMT3B in Acute Myeloid Leukaemia.
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Oncolytic adenovirus-expressed RNA interference of O(6)-methylguanine DNA methyltransferase activity may enhance the antitumor effects of temozolomide.
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Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers.
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Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes.
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Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44+ cancer stem cells to 5 azacytidine in hepatocellular carcinoma.
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Over-expression of DNMT3A predicts the risk of recurrent vulvar squamous cell carcinomas.
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Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation.
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Overexpression of DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) And DNA (Cytosine-5)-Methyltransferase 3A (DNMT3A) Is Associated with Aggressive Behavior and Hypermethylation of Tumor Suppressor Genes in Human Pituitary Adenomas.
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Overexpression of DNA methyltransferase 1 (DNMT1) protein in astrocytic tumour and its correlation with O6-methylguanine-DNA methyltransferase (MGMT) expression.
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Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma.
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Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer.
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Overexpression of transposable elements is associated with immune evasion and poor outcome in colorectal cancer.
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P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib.
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Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
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Pan-cancer analysis of RNA methyltransferases identifies FTSJ3 as a potential regulator of breast cancer progression.
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Paradoxical association of TET loss of function with genome-wide DNA hypomethylation.
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PART-1 functions as a competitive endogenous RNA for promoting tumor progression by sponging miR-143 in colorectal cancer.
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Peperomin E reactivates silenced tumor suppressor genes in lung cancer cells via inhibition of DNA methyltransferase.
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Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome.
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Pharmaco-epigenomics: discovering therapeutic approaches and biomarkers for cancer therapy.
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Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency.
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Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors.
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Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.
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Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
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Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study.
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Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation.
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Physcion 8-O-?-glucopyranoside induces apoptosis, suppresses invasion and inhibits epithelial to mesenchymal transition of hepatocellular carcinoma HepG2 cells.
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piR-823 demonstrates tumor oncogenic activity in esophageal squamous cell carcinoma through DNA methylation induction via DNA methyltransferase 3B.
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piRNA-823 contributes to tumorigenesis by regulating de novo DNA methylation and angiogenesis in multiple myeloma.
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piRNA-823 Is Involved in Cancer Stem Cell Regulation Through Altering DNA Methylation in Association With Luminal Breast Cancer.
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Plasma and cerebrospinal fluid pharmacokinetics of the DNA methyltransferase inhibitor, 5-azacytidine, alone and with inulin, in nonhuman primate models.
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Polycomb and DNA methyltransferase complexes participate in global and focal epigenetic alteration in cancer cells.
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Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma.
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Polymorphism of DNA methyltransferase 3B -149C/T and cancer risk: a meta-analysis.
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Polymorphism of DNA Methyltransferase 3b and Association with Development and Prognosis in Gastric Cancer.
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Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study.
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Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesis.
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Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy.
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PPAR-Responsive Elements Enriched with Alu Repeats May Contribute to Distinctive PPAR?-DNMT1 Interactions in the Genome.
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Predictive factors for the sensitivity of radiotherapy and prognosis of esophageal squamous cell carcinoma.
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Presence of a consensus DNA motif at nearby DNA sequence of the mutation susceptible CG nucleotides.
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Prevalence, predictors, and outcomes of clonal hematopoiesis in individuals aged ?80 years.
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Primary CNS T-cell Lymphomas: A Clinical, Morphologic, Immunophenotypic, and Molecular Analysis.
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Progesterone receptor gene inactivation and CpG island hypermethylation in human leukemia cancer cells.
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Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo.
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Promoter hypermethylation of the O(6)-methylguanine DNA methyltransferase gene and microsatellite instability in metastatic melanoma.
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Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a.
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Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer.
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Promoter methylation, mRNA expression of goat tumor?associated genes and mRNA expression of DNA methyltransferase in enzootic nasal tumors.
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Promoter polymorphisms of DNA methyltransferase 3B and risk of hepatocellular carcinoma.
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Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study.
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Promoter polymorphisms of DNMT3B and the risk of head and neck squamous cell carcinoma in Taiwan: a case-control study.
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Prostaglandin E2 induces DNA hypermethylation in gastric cancer in vitro and in vivo.
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Protein arginine methyltransferase 5-mediated epigenetic silencing of IRX1 contributes to tumorigenicity and metastasis of gastric cancer.
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Protein expression trends of DNMT1 in gastrointestinal diseases: From benign to precancerous lesions to cancer.
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Protein expression, mRNA expression and gene amplification of DNA methyltransferase 1 in endometrial tumor tissues.
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Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors.
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Quantitative analysis of mRNA expression levels and DNA methylation profiles of three neighboring genes: FUS1, NPRL2/G21 and RASSF1A in non-small cell lung cancer patients.
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Quantitative analysis of promoter hypermethylation in multiple genes in osteosarcoma.
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Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome.
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Radiation-induced hypomethylation triggers urokinase plasminogen activator transcription in meningioma cells.
Neoplasms
Randomized trial of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemotherapy naive patients with metastatic cutaneous melanoma.
Neoplasms
Rapid restriction enzyme free detection of DNA methyltransferase activity based on DNA-templated silver nanoclusters.
Neoplasms
Rare mutations in DNMT3A in myeloproliferative neoplasms and myelodysplastic syndromes.
Neoplasms
RCC2 promotes proliferation and radio-resistance in glioblastoma via activating transcription of DNMT1.
Neoplasms
Re-expression of RASSF1A by 5-Aza-CdR induced demethylation of the promoter region in human biliary tract carcinoma cells.
Neoplasms
Reactivation of Atp4a concomitant with intragenic DNA demethylation for cancer inhibition in a gastric cancer model.
Neoplasms
Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors: basic concepts and clinical applications.
Neoplasms
Real-time PCR analysis of genes encoding tumor antigens in esophageal tumors and a cancer vaccine.
Neoplasms
Recessive cancer genes engage in negative genetic interactions with their functional paralogs.
Neoplasms
Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.
Neoplasms
Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression.
Neoplasms
Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice.
Neoplasms
Reduction of pancreatic cancer cell viability and induction of apoptosis mediated by siRNA targeting DNMT1 through suppression of total DNA methyltransferase activity.
Neoplasms
Reduction of two histone marks, H3k9me3 and H3k27me3 by epidrug induces neuroendocrine differentiation in prostate cancer.
Neoplasms
Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition.
Neoplasms
Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues.
Neoplasms
Regulation of carcinogenesis and modulation through Wnt/?-catenin signaling by curcumin in an ovarian cancer cell line.
Neoplasms
Regulation of DNA methylation and tumor suppression gene expression by miR-29b in leukemia patients and related mechanisms.
Neoplasms
Regulation of the DNA methylation machinery and its role in cellular transformation.
Neoplasms
Restoration of miR-101 suppresses lung tumorigenesis through inhibition of DNMT3a-dependent DNA methylation.
Neoplasms
Restoration of the methylation status of hypermethylated gene promoters by microRNA-29b in human breast cancer: A novel epigenetic therapeutic approach.
Neoplasms
Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells.
Neoplasms
Resveratrol-salicylate derivatives as selective DNMT3 inhibitors and anticancer agents.
Neoplasms
Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex.
Neoplasms
Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.
Neoplasms
Reversal of increased mammary tumorigenesis by valproic acid and hydralazine in offspring of dams fed high fat diet during pregnancy.
Neoplasms
RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation.
Neoplasms
RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation.
Neoplasms
RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis.
Neoplasms
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells.
Neoplasms
RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner.
Neoplasms
RNA methyltransferase NSUN2 promotes growth of hepatocellular carcinoma cells by regulating fizzy-related-1 in vitro and in vivo.
Neoplasms
RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner.
Neoplasms
RNAPol-ChIP analysis of transcription from FSHD-linked tandem repeats and satellite DNA.
Neoplasms
Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation.
Neoplasms
Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma.
Neoplasms
Role of DNA methyltransferase 1 in pharyngeal cancer related to treatment resistance.
Neoplasms
Role of estrogen receptor gene demethylation and DNA methyltransferase.DNA adduct formation in 5-aza-2'deoxycytidine-induced cytotoxicity in human breast cancer cells.
Neoplasms
Role of NADPH Oxidase NOX5-S, NF-kB and DNMT1 in Acid-Induced P16 Hypermethylation in Barrett's cells.
Neoplasms
Role of the cytosine DNA-methyltransferase and p16INK4a genes in the development of mouse lung tumors.
Neoplasms
RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment.
Neoplasms
S-allylcysteine suppresses ovarian cancer cell proliferation by DNA methylation through DNMT1.
Neoplasms
SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma.
Neoplasms
Selective inhibition of DNA methyltransferase enzymes as a novel strategy for cancer treatment.
Neoplasms
Selective inhibition of esophageal cancer cells by combination of HDAC inhibitors and Azacytidine.
Neoplasms
Self-Powered Biosensing Platform Based on "Signal-On" Enzymatic Biofuel Cell for DNA Methyltransferase Activity Analysis and Inhibitor Screening.
Neoplasms
Sensitive Electrochemical Detection of Human Methyltransferase Based on a Dual Signal Amplification Strategy Coupling Gold Nanoparticle-DNA Complexes with Ru(III) Redox Recycling.
Neoplasms
Sensitive fluorescent detection of DNA methyltransferase using nicking endonuclease-mediated multiple primers-like rolling circle amplification.
Neoplasms
Sensitive fluorescent detection of methyltransferase based on thermosensitive poly(N-isopropylacrylamide).
Neoplasms
Sensitive surface plasmon resonance detection of methyltransferase activity and screening of its inhibitors amplified by p53 protein bound to methylation-specific ds-DNA consensus sites.
Neoplasms
Serological identification and bioinformatics analysis of immunogenic antigens in multiple myeloma.
Neoplasms
si-DNMT1 restore tumor suppressor genes expression through the reversal of DNA hypermethylation in cholangiocarcinoma.
Neoplasms
Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer.
Neoplasms
Silencing DNA methyltransferase 1 (DNMT1) inhibits proliferation, metastasis and invasion in ESCC by suppressing methylation of RASSF1A and DAPK.
Neoplasms
Silencing DNA methyltransferase 1 leads to the activation of the esophageal suppressor gene p16 in vitro and in vivo.
Neoplasms
Silencing of miR-152 contributes to DNMT1-mediated CpG methylation of the PTEN promoter in bladder cancer.
Neoplasms
Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells.
Neoplasms
Single nucleotide polymorphism in DNMT3B promoter and its association with hepatocellular carcinoma in a Moroccan population.
Neoplasms
Single-nucleotide polymorphisms in DNMT3B gene and DNMT3B mRNA expression in association with prostate cancer mortality.
Neoplasms
Single-ribonucleotide repair-mediated ligation-dependent cycling signal amplification for sensitive and specific detection of DNA methyltransferase.
Neoplasms
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
Neoplasms
Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties.
Neoplasms
Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome.
Neoplasms
Specific inhibition of one DNMT1-including complex influences tumor initiation and progression.
Neoplasms
Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2.
Neoplasms
SPIRE - combining SGI-110 with cisplatin and gemcitabine chemotherapy for solid malignancies including bladder cancer: study protocol for a phase Ib/randomised IIa open label clinical trial.
Neoplasms
Splice variants DNMT3B4 and DNMT3B7 overexpression inhibit cell proliferation in 293A cell line.
Neoplasms
Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model.
Neoplasms
STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes.
Neoplasms
STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.
Neoplasms
STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and S-Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma.
Neoplasms
Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer.
Neoplasms
Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9.
Neoplasms
Structural optimization of non-nucleoside DNA methyltransferase inhibitor as anti-cancer agent.
Neoplasms
Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1 .
Neoplasms
Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors.
Neoplasms
Sulforaphane Alone and in Combination with Clofarabine Epigenetically Regulates the Expression of DNA Methylation-Silenced Tumour Suppressor Genes in Human Breast Cancer Cells.
Neoplasms
Sulforaphane Reverses the Expression of Various Tumor Suppressor Genes by Targeting DNMT3B and HDAC1 in Human Cervical Cancer Cells.
Neoplasms
Suppressing effects of down-regulating DNMT1 and DNMT3b expression on the growth of human cholangiocarcinoma cell line.
Neoplasms
Suppression of DNA methyltransferase 1 levels in head and neck squamous carcinoma cells using small interfering RNA results in growth inhibition and increase in Cdk inhibitor p21.
Neoplasms
Suppression of Wnt signaling by the miR-29 family is mediated by demethylation of WIF-1 in non-small-cell lung cancer.
Neoplasms
Suppression of Wnt1-induced mammary tumor growth and lower serum insulin in offspring exposed to maternal blueberry diet suggest early dietary influence on developmental programming.
Neoplasms
Synergetic effects of DNA demethylation and histone deacetylase inhibition in primary rat hepatocytes.
Neoplasms
Synergistic Effect of Epigenetic Inhibitors Decitabine and Suberoylanilide Hydroxamic Acid on Colorectal Cancer in vitro.
Neoplasms
Synergistic effect of trichostatin A and 5-aza-2'-deoxycytidine on growth inhibition of pancreatic endocrine tumour cell lines: a proteomic study.
Neoplasms
Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells.
Neoplasms
Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor.
Neoplasms
T Cell Exhaustion: An Epigenetically Imprinted Phenotypic and Functional Makeover.
Neoplasms
Tamoxifen accelerates proteasomal degradation of O(6)-methylguanine DNA methyltransferase in human cancer cells.
Neoplasms
Targeting cancer epigenetic pathways with small-molecule compounds: Therapeutic efficacy and combination therapies.
Neoplasms
Targeting cellular memory to reprogram the epigenome, restore potential, and improve somatic cell nuclear transfer.
Neoplasms
Targeting epigenetic networks with polypharmacology: a new avenue to tackle cancer.
Neoplasms
Targeting epigenetic pathway with gold nanoparticles for acute myeloid leukemia therapy.
Neoplasms
Targeting epigenetics for the treatment of prostate cancer: recent progress and future directions.
Neoplasms
TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer.
Neoplasms
Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.
Neoplasms
Telomerase reverse transcriptase regulates DNMT3B expression/aberrant DNA methylation phenotype and AKT activation in hepatocellular carcinoma.
Neoplasms
Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors.
Neoplasms
Temozolomide in advanced and recurrent uterine leiomyosarcoma and correlation with o6-methylguanine DNA methyltransferase expression: a case series.
Neoplasms
TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models.
Neoplasms
TGF-? regulates DNA methyltransferase expression in prostate cancer, correlates with aggressive capabilities, and predicts disease recurrence.
Neoplasms
The application of epigenetic modifiers on the treatment of prostate and bladder cancer.
Neoplasms
The association of DNA methyltransferase 1 gene polymorphisms with susceptibility to childhood acute lymphoblastic leukemia.
Neoplasms
The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype.
Neoplasms
The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells.
Neoplasms
The Cancer/Testis Antigen Gene VCX2 Is Rarely Expressed in Malignancies but Can Be Epigenetically Activated Using DNA Methyltransferase and Histone Deacetylase Inhibitors.
Neoplasms
The combination of dimethoxycurcumin with DNA methylation inhibitor enhances gene re-expression of promoter-methylated genes and antagonizes their cytotoxic effect.
Neoplasms
The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression.
Neoplasms
The DNA Methyltransferase 3B -149 Genetic Polymorphism Modulates Lung Cancer Risk from Smoking
Neoplasms
The DNA Methyltransferase DNMT1 and Tyrosine-Protein Kinase KIT Cooperatively Promote Resistance to 5-Aza-2'-deoxycytidine (Decitabine) and Midostaurin (PKC412) in Lung Cancer Cells.
Neoplasms
The DNA methyltransferase inhibitor zebularine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo.
Neoplasms
The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer.
Neoplasms
The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells.
Neoplasms
The DNA-methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells.
Neoplasms
The DNMT1/miR-34a Axis Is Involved in the Stemness of Human Osteosarcoma Cells and Derived Stem-Like Cells.
Neoplasms
The DNMT3B C-->T promoter polymorphism and risk of breast cancer in a British population: a case-control study.
Neoplasms
The effect of acute dichlorodiphenyltrichloroethane exposure on hypermethylation status and down-regulation of p53 and p16(INK4a) genes in rat liver.
Neoplasms
The effect of azacitidine on interleukin-6 signaling and nuclear factor-kappaB activation and its in vitro and in vivo activity against multiple myeloma.
Neoplasms
The effect of decitabine on the expression and methylation of the PPP1CA, BTG2, and PTEN in association with changes in miR-125b, miR-17, and miR-181b in NALM6 cell line.
Neoplasms
The effect of folate-related SNPs on clinicopathological features, response to neoadjuvant treatment and survival in pre- and postmenopausal breast cancer patients.
Neoplasms
The Effect of Hormone Therapy on the Expression of Prostate Cancer and Multi-Epigenetic Marker Genes in a Population of Iranian Patients.
Neoplasms
The epigenetic agents suberoylanilide hydroxamic acid and 5?AZA?2' deoxycytidine decrease cell proliferation, induce cell death and delay the growth of MiaPaCa2 pancreatic cancer cells in vivo.
Neoplasms
The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer.
Neoplasms
The Histone Deacetylase Inhibitor JAHA Down-Regulates pERK and Global DNA Methylation in MDA-MB231 Breast Cancer Cells.
Neoplasms
The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells.
Neoplasms
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.
Neoplasms
The interaction between miR?148a and DNMT1 suppresses cell migration and invasion by reactivating tumor suppressor genes in pancreatic cancer.
Neoplasms
The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells.
Neoplasms
The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy.
Neoplasms
The interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent.
Neoplasms
The involvement of promoter methylation and DNA methyltransferase-1 in the regulation of EpCAM expression in oral squamous cell carcinoma.
Neoplasms
The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma.
Neoplasms
The loss-of-function of DNA methyltransferase 1 by siRNA impairs the growth of non-small cell lung cancer with alleviated side effects via reactivation of RASSF1A and APC in vitro and vivo.
Neoplasms
The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine.
Neoplasms
The negative feedback between miR-143 and DNMT3A regulates cisplatin resistance in ovarian cancer.
Neoplasms
The pivotal role of DNA methylation in the radio-sensitivity of tumor radiotherapy.
Neoplasms
The possible role of EZH2 and DNMT1 polymorphisms in sporadic triple-negative breast carcinoma in southern Chinese females.
Neoplasms
The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity.
Neoplasms
The R882H substitution in the human de novo DNA methyltransferase DNMT3A disrupts allosteric regulation by the tumor supressor p53.
Neoplasms
The role of a ginseng saponin metabolite as a DNA methyltransferase inhibitor in colorectal cancer cells.
Neoplasms
The role of BLIMP1 and its putative downstream target TFAP2C in germ cell development and germ cell tumours.
Neoplasms
The Role of Dietary Extra Virgin Olive Oil and Corn Oil on the Alteration of Epigenetic Patterns in the Rat DMBA-Induced Breast Cancer Model.
Neoplasms
The role of DNA damage and repair in decitabine-mediated apoptosis in multiple myeloma.
Neoplasms
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients.
Neoplasms
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in Laryngeal carcinoma.
Neoplasms
Theaflavin-Containing Black Tea Extract: A Potential DNA Methyltransferase Inhibitor in Human Colon Cancer Cells and Ehrlich Ascites Carcinoma-Induced Solid Tumors in Mice.
Neoplasms
Therapeutic potential of DNA methyltransferase inhibitors with immune checkpoint inhibitor therapy in breast cancer.
Neoplasms
Therapy-related acute lymphoblastic leukemia is a distinct entity with adverse genetic features and clinical outcomes.
Neoplasms
Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells.
Neoplasms
Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms.
Neoplasms
Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.
Neoplasms
Tissue-specific induced DNA methyltransferase 1 (Dnmt1) in endocrine pancreas by RCAS-TVA-based somatic gene transfer system promotes ?-cell proliferation.
Neoplasms
Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation.
Neoplasms
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Neoplasms
Transcriptional analysis of CXCR4, DNMT3A, DNMT3B and DNMT1 gene expression in primary advanced uterine cervical carcinoma.
Neoplasms
Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts.
Neoplasms
Transcriptional regulation of urokinase (uPA) gene expression in breast cancer cells: role of DNA methylation.
Neoplasms
Treatment with a DNA methyltransferase inhibitor feminizes zebrafish and induces long-term expression changes in the gonads.
Neoplasms
Trimethylaurintricarboxylic acid inhibits human DNA methyltransferase 1: insights from enzymatic and molecular modeling studies.
Neoplasms
tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells.
Neoplasms
Truncated DNMT3B Isoform DNMT3B7 Suppresses Growth, Induces Differentiation, and Alters DNA Methylation in Human Neuroblastoma.
Neoplasms
Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis.
Neoplasms
Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase.
Neoplasms
Tumor-Associated Macrophages Promote Epigenetic Silencing of Gelsolin through DNA Methyltransferase 1 in Gastric Cancer Cells.
Neoplasms
Two Case Reports of Resensitization to Previous Chemotherapy with the Novel Hypoxia-Activated Hypomethylating Anticancer Agent RRx-001 in Metastatic Colorectal Cancer Patients.
Neoplasms
Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands.
Neoplasms
Two siblings with immunodeficiency, facial abnormalities and chromosomal instability without mutation in DNMT3B gene but liability towards malignancy; a new chromatin disorder delineation?
Neoplasms
UHRF1 Induces Methylation of the TXNIP Promoter and Down-Regulates Gene Expression in Cervical Cancer.
Neoplasms
Ultrasensitive and Accurate Assay of Human Methyltransferase Activity at the Single-Cell Level Based on a Single Integrated Magnetic Microprobe.
Neoplasms
Up-regulation of DNA-methyltransferase 3A expression is associated with hypomethylation of intron 25 in human testicular germ cell tumors.
Neoplasms
Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6.
Neoplasms
Upregulation of miR-137 Expression Suppresses Tumor Growth and Progression via Interacting with DNMT3a Through Inhibiting the PTEN/Akt Signaling in HCC.
Neoplasms
Upregulation of SPP1 Is a Marker for Poor Lung Cancer Prognosis and Contributes to Cancer Progression and Cisplatin Resistance.
Neoplasms
USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and ?-TrCP and promotes cancer malignancy.
Neoplasms
Utilization of antisense oligonucleotides to study the role of 5-cytosine DNA methyltransferase in cellular transformation and oncogenesis.
Neoplasms
Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells.
Neoplasms
Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoiesis.
Neoplasms
VEGFA activates an epigenetic pathway upregulating ovarian cancer-initiating cells.
Neoplasms
Whole exome sequencing reveals mutations in FAT1 tumor suppressor gene clinically impacting on peripheral T-cell lymphoma not otherwise specified.
Neoplasms
YY1-mediated long non-coding RNA Kcnq1ot1 promotes the tumor progression by regulating PTEN via DNMT1 in triple negative breast cancer.
Neoplasms
Zebularine elevates STING expression and enhances cGAMP cancer immunotherapy in mice.
Neoplasms
Zebularine exerts its antiproliferative activity through S phase delay and cell death in human malignant mesothelioma cells.
Neoplasms
Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells.
Neoplasms
Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP.
Neoplasms
[Antisense DNMT1 gene fragment in the sensitivity change of SMMC-7721 cells to tumor necrosis factor related apoptosis inducing ligand and its mechanism]
Neoplasms
[Arsenic Trioxide Reverses Hypermethylation of p16 and Activates Its Transcription in Malignant Lymphoma Cell Line CA46.]
Neoplasms
[Characteristic and clinical significance of DNA methyltransferase 3B overexpression in endometrial carcinoma].
Neoplasms
[Decitabine treatment in myelodysplastic syndromes--results of a compassionate patient program in Israel].
Neoplasms
[DNA methyltransferases: the role in regulation of gene expression and biological processes]
Neoplasms
[Effect of phenelzine on the proliferation, apoptosis and histone methylation and acetylation of Molt-4 cells].
Neoplasms
[Effect of stable DNA methyltransferase 3bknockdown on proliferation and apoptosis in bladder cancer cells in vitro].
Neoplasms
[Effects of dnmt1 Gene Silencing on Cell Cycle, Proliferation, and Apoptosis of Gastric Cancer Cell Line AGS.]
Neoplasms
[Expression of DNA methyltransferase 1, 3A and 3B mRNA in the epithelial ovarian carcinoma]
Neoplasms
[Expression of DNA methyltransferases in salivary adenoid cystic carcinoma and its association with the CpG islands methylation of tumor suppressor genes]
Neoplasms
[Expression of DNMT3b in human bladder cancer tissue and its correlation with clinical prognosis].
Neoplasms
[Expression of ER alpha in chemically induced MDA-MB-435 cells and its responsiveness to endocrine]
Neoplasms
[Gene expressions of DNA methyltransferase 1 and human leukocyte antigen-DRalpha in hepatocelluar carcinoma and their clinical significance.]
Neoplasms
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
Neoplasms
[High expression of DNMT3B promotes proliferation and invasion of hepatocellular carcinoma cells via Hippo signaling pathway].
Neoplasms
[Inhibitory effect of 5-Aza-2'-deoxycytidine on human nasopharyngeal carcinoma xenograft in nude mice]
Neoplasms
[Methylation and demethylation of SOX2 gene promoter in BGC-823 gastric cancer cells].
Neoplasms
[Regulation of Gene Expression of Cancer/Testis Antigens in Colorectal Cancer Patients].
Neoplasms
[The Relationship of Clinicopathology of p16 in Non-small Cell Lung Cancer and 5-nitrogen impurity-2'-deoxycytidine-nitrogen Impurity on the Influence of p16 Expression in Lung Cancer A549 Cells].
Neoplasms, Germ Cell and Embryonal
A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor.
Neoplasms, Germ Cell and Embryonal
A novel somatic MAPK1 mutation in primary ovarian mixed germ cell tumors.
Neoplasms, Germ Cell and Embryonal
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.
Neoplasms, Germ Cell and Embryonal
High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors.
Neoplasms, Germ Cell and Embryonal
The role of BLIMP1 and its putative downstream target TFAP2C in germ cell development and germ cell tumours.
Neoplasms, Germ Cell and Embryonal
Up-regulation of DNA-methyltransferase 3A expression is associated with hypomethylation of intron 25 in human testicular germ cell tumors.
Nephritis
Expanding the phenotype of biallelic loss-of-function variants in the NSUN2 gene: Description of four individuals with juvenile cataract, chronic nephritis, or brain anomaly as novel complications.
Nervous System Diseases
Abnormalities of the DNA methylation mark and its machinery: an emerging cause of neurologic dysfunction.
Nervous System Diseases
Defects of mutant DNMT1 are linked to a spectrum of neurological disorders.
Neural Tube Defects
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Neuralgia
Author Correction: DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons.
Neuralgia
Change in microRNAs associated with neuronal adaptive responses in the nucleus accumbens under neuropathic pain.
Neuralgia
Contribution of DNMT1 to Neuropathic Pain Genesis Partially through Epigenetically Repressing Kcna2 in Primary Afferent Neurons.
Neuralgia
Contribution of dorsal root ganglion octamer transcription factor 1 to neuropathic pain after peripheral nerve injury.
Neuralgia
CREB Participates in Paclitaxel-Induced Neuropathic Pain Genesis Through Transcriptional Activation of Dnmt3a in Primary Sensory Neurons.
Neuralgia
Demethylation of G-Protein-Coupled Receptor 151 Promoter Facilitates the Binding of Krüppel-Like Factor 5 and Enhances Neuropathic Pain after Nerve Injury in Mice.
Neuralgia
DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons.
Neuralgia
DNMT3b SUMOylation Mediated MMP-2 Upregulation Contribute to Paclitaxel Induced Neuropathic Pain.
Neuralgia
Intrathecal 5-azacytidine inhibits global DNA methylation and methyl- CpG-binding protein 2 expression and alleviates neuropathic pain in rats following chronic constriction injury.
Neuralgia
Nerve Injury-Induced Epigenetic Silencing Of Opioid Receptors Controlled By Dnmt3a In Primary Afferent Neurons.
Neuroblastoma
A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma.
Neuroblastoma
Differential expression of DNA-methyltransferases in drug resistant murine neuroblastoma cells.
Neuroblastoma
Inhibition of DNA methyltransferase reverses cisplatin induced drug resistance in murine neuroblastoma cells.
Neuroblastoma
Liganded Thyroid Hormone Receptors Transactivate the DNA Methyltransferase 3a Gene in Mouse Neuronal Cells.
Neuroblastoma
RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity.
Neuroblastoma
Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature.
Neuroblastoma
Truncated DNMT3B Isoform DNMT3B7 Suppresses Growth, Induces Differentiation, and Alters DNA Methylation in Human Neuroblastoma.
Neurodegenerative Diseases
Comparison of the Effects of Curcumin and RG108 on NGF-Induced PC-12?Adh Cell Differentiation and Neurite Outgrowth.
Neurodegenerative Diseases
Disease-Associated Mutations G589A and V590F Relieve Replication Focus Targeting Sequence-Mediated Autoinhibition of DNA Methyltransferase 1.
Neurodegenerative Diseases
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
Neurodegenerative Diseases
Lack of association between DNMT1 gene polymorphisms and noise-induced hearing loss in a Chinese population.
Neurodegenerative Diseases
Mutation-induced DNMT1 cleavage drives neurodegenerative disease.
Neurodegenerative Diseases
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.
Neurodegenerative Diseases
PDmethDB: A curated Parkinson's disease associated methylation information database.
Neurodegenerative Diseases
The replication foci targeting sequence (RFTS) of DNMT1 functions as a potent histone H3 binding domain regulated by autoinhibition.
Neuroectodermal Tumors, Primitive
CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity.
Neuroendocrine Tumors
DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors.
Neuroendocrine Tumors
Tissue-specific induced DNA methyltransferase 1 (Dnmt1) in endocrine pancreas by RCAS-TVA-based somatic gene transfer system promotes ?-cell proliferation.
Neuroinflammatory Diseases
Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice.
Neuronal Ceroid-Lipofuscinoses
Genetic and phenotypic characterization of complex hereditary spastic paraplegia.
Nevus
Expression of DNA Methyltransferase 1 Is a Hallmark of Melanoma, Correlating with Proliferation and Response to B-Raf and Mitogen-Activated Protein Kinase Inhibition in Melanocytic Tumors.
Non-alcoholic Fatty Liver Disease
Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A.
Obesity
Comparative transcriptome analysis identifies CARM1 and DNMT3A as genes associated with osteoporosis.
Obesity
DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics.
Obesity
Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice.
Obesity
Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells.
Obesity
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.
Obesity
Maternal obesity alters the expression of embryonic regulatory transcripts in the preimplantation ovine conceptus.
Obesity
Obesity Associated Modulation of miRNA and Co-Regulated Target Transcripts in Human Adipose Tissue of Non-Diabetic Subjects.
Obesity
Obesity promotes the global hypomethylation of CD4+ T cells in patients with systemic lupus erythematosus via downregulating DNMT1.
Obesity
The Impact of Maternal Pre-Pregnancy Body Weight and Gestational Diabetes on Markers of Folate Metabolism in the Placenta.
Obesity
The Level of Feed Intake Affects Embryo Survival and Gene Expression During Early Pregnancy in Gilts.
Obesity, Maternal
Maternal obesity alters the expression of embryonic regulatory transcripts in the preimplantation ovine conceptus.
Odontogenic Tumors
DNA methyltransferase immunohistochemical expression in odontogenic tumours.
Oligodendroglioma
Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors.
Oligospermia
Decreased expression of DNA methyltransferases in the testes of patients with non-obstructive azoospermia leads to changes in global DNA methylation levels.
Osteoarthritis
CircRNA circ_SEC24A upregulates DNMT3A expression by sponging miR-26b-5p to aggravate osteoarthritis progression.
Osteoarthritis
Downregulation of microRNA-29b by DNMT3B decelerates chondrocyte apoptosis and the progression of osteoarthritis via PTHLH/CDK4/RUNX2 axis.
Osteoarthritis
Effect of the interaction between MiR-200b-3p and DNMT3A on cartilage cells of osteoarthritis patients.
Osteoarthritis
Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis.
Osteoarthritis
Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1?-Induced Osteoarthritis Progression Through Regulating DNMT3A.
Osteoarthritis
Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice.
Osteoarthritis
MiR-33b-3p promotes chondrocyte proliferation and inhibits chondrocyte apoptosis and cartilage ECM degradation by targeting DNMT3A in osteoarthritis.
Osteoarthritis, Hip
Evaluation of relationship between DNA methyltransferase 3 ? gene and the risk of hip osteoarthritis: A case-control study based on a Han Chinese population.
Osteoarthritis, Knee
DNA methyltransferase genes polymorphisms are associated with primary knee osteoarthritis: a matched case-control study.
Osteoarthritis, Knee
Does DNMT3B gene contribute the shared susceptibility to knee osteoarthritis and hip osteoarthritis?
Osteoarthritis, Knee
MicroRNA-199-3p up-regulation enhances chondrocyte proliferation and inhibits apoptosis in knee osteoarthritis via DNMT3A repression.
Osteolysis
Epigenetic regulation of HGF/Met receptor axis is critical for the outgrowth of bone metastasis from breast carcinoma.
Osteoporosis
Comparative transcriptome analysis identifies CARM1 and DNMT3A as genes associated with osteoporosis.
Osteoporosis
Overexpression of DNMT1 leads to hypermethylation of H19 promoter and inhibition of Erk signaling pathway in disuse osteoporosis.
Osteoporosis
Oxidative Stress-Induced Hypermethylation of KLF5 Promoter Mediated by DNMT3B Impairs Osteogenesis by Diminishing the Interaction with ?-Catenin.
Osteosarcoma
A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy.
Osteosarcoma
DNA methylation-mediated downregulation of PTPN3 attenuates to boost TGF-? signaling in osteosarcoma cells.
Osteosarcoma
Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma.
Osteosarcoma
Epigenetic regulation of the pro-apoptosis gene TSSC3 in human osteosarcoma cells.
Osteosarcoma
Expression profiling of DNA methyl transferase I (DNMT1) and efficacy of a DNA-hypomethylating agent (decitabine) in combination with chemotherapy in osteosarcoma.
Osteosarcoma
Isovitexin Suppresses Cancer Stemness Property And Induces Apoptosis Of Osteosarcoma Cells By Disruption Of The DNMT1/miR-34a/Bcl-2 Axis.
Osteosarcoma
Kruppel-Like Factor 9 Loss-of-Expression in Human Endometrial Carcinoma Links Altered Expression of Growth-Regulatory Genes with Aberrant Proliferative Response to Estrogen.
Osteosarcoma
LncRNA SNHG7 participates in osteosarcoma progression by down-regulating p53 via binding to DNMT1.
Osteosarcoma
MicroRNA-29a suppresses the invasion and migration of osteosarcoma cells by regulating the SOCS1/NF-?B signalling pathway through negatively targeting DNMT3B.
Osteosarcoma
MiR-139-5p suppresses osteosarcoma cell growth and invasion through regulating DNMT1.
Osteosarcoma
Separate and combined effects of DNMT and HDAC inhibitors in treating human multi-drug resistant osteosarcoma HosDXR150 cell line.
Osteosarcoma
Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells.
Osteosarcoma
Zebularine enhances apoptosis of human osteosarcoma cells by suppressing methylation of ARHI.
Otitis Media
ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media.
Otitis Media
The Moraxella catarrhalis phase-variable DNA methyltransferase ModM3 is an epigenetic regulator that affects bacterial survival in an in vivo model of otitis media.
Ovarian Neoplasms
A Feedback Loop Between miR-30a/c-5p and DNMT1 Mediates Cisplatin Resistance in Ovarian Cancer Cells.
Ovarian Neoplasms
An Effective Epigenetic-PARP inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA-mutations.
Ovarian Neoplasms
Association of tRNA methyltransferase NSUN2/IGF-II molecular signature with ovarian cancer survival.
Ovarian Neoplasms
Clinicopathological significance and prognostic value of DNA methyltransferase 1, 3a, and 3b expressions in sporadic epithelial ovarian cancer.
Ovarian Neoplasms
Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells.
Ovarian Neoplasms
DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells.
Ovarian Neoplasms
DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation.
Ovarian Neoplasms
DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population.
Ovarian Neoplasms
Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation.
Ovarian Neoplasms
Double-negative feedback interaction between DNA methyltransferase 3A and microRNA-145 in the Warburg effect of ovarian cancer cells.
Ovarian Neoplasms
Downregulation of DNMT3a expression increases miR-182-induced apoptosis of ovarian cancer through caspase-3 and caspase-9-mediated apoptosis and DNA damage response.
Ovarian Neoplasms
Effect of the HDAC Inhibitor on Histone Acetylation and Methyltransferases in A2780 Ovarian Cancer Cells.
Ovarian Neoplasms
Epigenetic activation of MGAT3 and corresponding bisecting GlcNAc shortens the survival of cancer patients.
Ovarian Neoplasms
Epigenetic modifications of the Estrogen receptor beta gene in epithelial ovarian cancer cells.
Ovarian Neoplasms
Epigenetic modifiers upregulate MHC II and impede ovarian cancer tumor growth.
Ovarian Neoplasms
Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells.
Ovarian Neoplasms
Epigenetic regulation of RGS2 (Regulator of G-protein signaling 2) in chemoresistant ovarian cancer cells.
Ovarian Neoplasms
Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy.
Ovarian Neoplasms
Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer.
Ovarian Neoplasms
Epigenetic-mediated immune suppression of positive co-stimulatory molecules in chemoresistant ovarian cancer cells.
Ovarian Neoplasms
Genomic and Epigenomic Signatures in Ovarian Cancer Associated with Resensitization to Platinum Drugs.
Ovarian Neoplasms
Increased DNA methyltransferase activity and DNA methylation following Epidermal Growth Factor stimulation in ovarian cancer cells.
Ovarian Neoplasms
Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance.
Ovarian Neoplasms
Investigation of the expression patterns and correlation of DNA methyltransferases and class I histone deacetylases in ovarian cancer tissues.
Ovarian Neoplasms
KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.
Ovarian Neoplasms
Live-attenuated measles virus vaccine confers cell contact loss and apoptosis of ovarian cancer cells via ROS-induced silencing of E-cadherin by methylation.
Ovarian Neoplasms
Messenger RNA expression and methylation of candidate tumor-suppressor genes and risk of ovarian cancer-a case-control analysis.
Ovarian Neoplasms
miR-145 promotes miR-133b expression through c-myc and DNMT3A-mediated methylation in ovarian cancer cells.
Ovarian Neoplasms
MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine.
Ovarian Neoplasms
Nicotinamide adenine dinucleotide (NAD) may affect DNA methyltransferase 1 through regulation of BRCA1 in ovarian cancer.
Ovarian Neoplasms
Overcoming immune suppression with epigenetic modification in ovarian cancer.
Ovarian Neoplasms
Prostaglandin E2 Leads to the Acquisition of DNMT3A-Dependent Tolerogenic Functions in Human Myeloid-Derived Suppressor Cells.
Ovarian Neoplasms
Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation.
Ovarian Neoplasms
S-allylcysteine suppresses ovarian cancer cell proliferation by DNA methylation through DNMT1.
Ovarian Neoplasms
Suppressing miR-199a-3p by promoter methylation contributes to tumor aggressiveness and cisplatin resistance of ovarian cancer through promoting DDR1 expression.
Ovarian Neoplasms
The negative feedback between miR-143 and DNMT3A regulates cisplatin resistance in ovarian cancer.
Ovarian Neoplasms
Transcriptional analysis of multiple ovarian cancer cohorts reveals prognostic and immunomodulatory consequences of ERV expression.
Ovarian Neoplasms
[Expression of DNA methyltransferase 1, 3A and 3B mRNA in the epithelial ovarian carcinoma]
Ovarian Neoplasms
[Ginsenoside 20(S)-Rg3 upregulates tumor suppressor VHL gene expression by suppressing DNMT3A-mediated promoter methylation in ovarian cancer cells].
Pancreatic Neoplasms
A pilot clinical trial of the cytidine deaminase inhibitor tetrahydrouridine combined with decitabine to target DNMT1 in advanced, chemorefractory pancreatic cancer.
Pancreatic Neoplasms
Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models.
Pancreatic Neoplasms
Correlations among PPAR?, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer.
Pancreatic Neoplasms
DNA methyltransferase 3a modulates chemosensitivity to gemcitabine and oxaliplatin via CHK1 and AKT in p53?deficient pancreatic cancer cells.
Pancreatic Neoplasms
DNA methyltransferase mediates the hypermethylation of the microRNA 34a promoter and enhances the resistance of patient-derived pancreatic cancer cells to molecular targeting agents.
Pancreatic Neoplasms
DNA-Methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Krüppel-Like Factor 4 Expression.
Pancreatic Neoplasms
DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications.
Pancreatic Neoplasms
DNMT1 Inhibition Reprograms Pancreatic Cancer Stem Cells via Upregulation of the miR-17-92 Cluster.
Pancreatic Neoplasms
DNMT3a promotes proliferation by activating the STAT3 signaling pathway and depressing apoptosis in pancreatic cancer.
Pancreatic Neoplasms
Downregulation of miR?29b targets DNMT3b to suppress cellular apoptosis and enhance proliferation in pancreatic cancer.
Pancreatic Neoplasms
Effect of Zebularine on p16INK4a, p14ARF, p15INK4b, and DNA Methyltransferase 1 Gene Expression, Cell Growth Inhibition, and Apoptosis Induction in Human Hepatocellular Carcinoma PLC/PRF5 and Pancreatic Cancer PA-TU-8902 Cell Lines.
Pancreatic Neoplasms
Epigenetic Regulation Affects N-myc Downstream-Regulated Gene 1 Expression Indirectly in Pancreatic Cancer Cells.
Pancreatic Neoplasms
Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells.
Pancreatic Neoplasms
Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth.
Pancreatic Neoplasms
Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic cancer.
Pancreatic Neoplasms
Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling.
Pancreatic Neoplasms
Increased CXCR4 expression in AsPC1 pancreatic carcinoma cells with RNA interference-mediated knockdown of DNMT1 and DNMT3B.
Pancreatic Neoplasms
Interplay between menin and Dnmt1 reversibly regulates pancreatic cancer cell growth downstream of the Hedgehog signaling pathway.
Pancreatic Neoplasms
Krüppel-like factor 10 expression as a prognostic indicator for pancreatic adenocarcinoma.
Pancreatic Neoplasms
MeCP2 suppresses LIN28A expression via binding to its methylated-CpG islands in pancreatic cancer cells.
Pancreatic Neoplasms
Methylation of the miR?29b?3p promoter contributes to angiogenesis, invasion, and migration in pancreatic cancer.
Pancreatic Neoplasms
MicroRNA-148b and microRNA-152 reactivate tumor suppressor genes through suppression of DNA methyltransferase-1 gene in pancreatic cancer cell lines.
Pancreatic Neoplasms
MiR-29b suppresses proliferation and mobility by targeting SOX12 and DNMT3b in pancreatic cancer.
Pancreatic Neoplasms
MiR-377 reverses cancerous phenotypes of pancreatic cells via suppressing DNMT1 and demethylating tumor suppressor genes.
Pancreatic Neoplasms
MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer.
Pancreatic Neoplasms
Neuronal pentraxin II (NPTX2) Is Frequently Down-Regulated by Promoter Hypermethylation in Pancreatic Cancers.
Pancreatic Neoplasms
Pancreatic cancer DNMT1 expression and sensitivity to DNMT1 inhibitors.
Pancreatic Neoplasms
Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice.
Pancreatic Neoplasms
Reduction of pancreatic cancer cell viability and induction of apoptosis mediated by siRNA targeting DNMT1 through suppression of total DNA methyltransferase activity.
Pancreatic Neoplasms
Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer.
Pancreatic Neoplasms
The interaction between miR?148a and DNMT1 suppresses cell migration and invasion by reactivating tumor suppressor genes in pancreatic cancer.
Pancreatic Neoplasms
The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy.
Pancreatic Neoplasms
Time-Qualified Patterns of Variation of PPAR?, DNMT1, and DNMT3B Expression in Pancreatic Cancer Cell Lines.
Pancreatic Neoplasms
Transcriptional activity of DNMT3B in pancreatic cancer cells: Effects of -149 (C?T) promoter polymorphism.
Pancreatic Neoplasms
Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis.
Panniculitis
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease.
Papilloma
Black raspberries demethylate Sfrp4, a WNT pathway antagonist, in rat esophageal squamous cell papilloma.
Papillomavirus Infections
An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection.
Papillomavirus Infections
Differential Wnt-?- catenin pathway activation in HPV positive and negative oral epithelium is transmitted during head and neck tumorigenesis: clinical implications.
Paraganglioma
Novel DNMT3A Germline Variant in a Patient with Multiple Paragangliomas and Papillary Thyroid Carcinoma.
Paraplegia
Genetic and phenotypic characterization of complex hereditary spastic paraplegia.
Paraproteinemias
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Paraproteinemias
Genome-wide transcriptional response to 5-aza-2'-deoxycytidine and trichostatin a in multiple myeloma cells.
Paratuberculosis
Rapid and sensitive method to identify Mycobacterium avium subsp. paratuberculosis in cow's milk by DNA methylase genotyping.
Parkinson Disease
Association between DNA methyltransferase gene polymorphism and Parkinson's disease.
Parkinson Disease
Association of DNMT3b gene variants with sporadic Parkinson's disease in a Chinese Han population.
Parkinson Disease
DNA Methyltransferase 1 Is Dysregulated in Parkinson's Disease via Mediation of miR-17.
Parkinson Disease
Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson's Disease in a Han Chinese Population.
Parkinson Disease
Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health.
Parkinson Disease
PDmethDB: A curated Parkinson's disease associated methylation information database.
Parkinson Disease
Protective effect of plastrum testudinis extract on dopaminergic neurons in a Parkinson's disease model through DNMT1 nuclear translocation and SNCA's methylation.
Penile Neoplasms
Multidimensional integrative analysis uncovers driver candidates and biomarkers in penile carcinoma.
Periodontitis
Decitabine Inhibits Bone Resorption in Periodontitis by Upregulating Anti-Inflammatory Cytokines and Suppressing Osteoclastogenesis.
Periodontitis
miR-9-1 gene methylation and DNMT3B (rs2424913) polymorphism may contribute to periodontitis.
Periodontitis
Porphyromonas gingivalis lipopolysaccharide stimulation in human periodontal ligament stem cells: role of epigenetic modifications to the inflammation.
Periodontitis
Porphyromonas gingivalis LPS stimulation downregulates DNMT1, DNMT3a, and JMJD3 gene expression levels in human HaCaT keratinocytes.
Peripheral Nerve Injuries
Contribution of DNMT1 to Neuropathic Pain Genesis Partially through Epigenetically Repressing Kcna2 in Primary Afferent Neurons.
Peripheral Nerve Injuries
DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons.
Peripheral Nerve Injuries
Role of MicroRNA-143 in Nerve Injury-Induced Upregulation of Dnmt3a Expression in Primary Sensory Neurons.
Peripheral Nervous System Diseases
DNMT1, a Novel Regulator Mediating mTORC1/mTORC2 Pathway-Induced NGF Expression in Schwann Cells.
Peripheral Nervous System Diseases
The Akt/mTOR cascade mediates high glucose-induced reductions in BDNF via DNMT1 in Schwann cells in diabetic peripheral neuropathy.
Peripheral Nervous System Diseases
TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression.
Pharyngeal Neoplasms
Role of DNA methyltransferase 1 in pharyngeal cancer related to treatment resistance.
Pinealoma
Expression of O(6) -methylguanine DNA methyltransferase (MGMT) and immunohistochemical analysis of 12 pineal parenchymal tumors.
Pituitary ACTH Hypersecretion
High incidence of low O(6)-methylguanine DNA methyltransferase expression in invasive macroadenomas of Cushing's disease.
Pituitary Neoplasms
Genome-wide analysis in a murine dnmt1 knockdown model identifies epigenetically silenced genes in primary human pituitary tumors.
Pituitary Neoplasms
O(6)-methylguanine DNA methyltransferase immunoexpression in nonfunctioning pituitary adenomas: are progressive tumors potential candidates for temozolomide treatment?
Pituitary Neoplasms
Overexpression of DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) And DNA (Cytosine-5)-Methyltransferase 3A (DNMT3A) Is Associated with Aggressive Behavior and Hypermethylation of Tumor Suppressor Genes in Human Pituitary Adenomas.
Pituitary Neoplasms
Recent clinical and pathophysiological advances in non-functioning pituitary adenomas.
Plague
[Comparison of specific recognition sites of adenine and cytosine DNA-methylase of Yersinia Pestis EV 76 C dam and dcm by Escherichia coli methylases]
Plasmacytoma
De novo and maintenance DNA methylation by a mouse plasmacytoma cell DNA methyltransferase.
Pneumonia
Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection.
Pneumonia
DNA methyltransferase inhibitor alleviates bleomycin-induced pulmonary inflammation.
Pneumonia
Regulatory T Cell DNA Methyltransferase Inhibition Accelerates Resolution of Lung Inflammation.
Polycythemia Vera
Clonal and lineage analysis of somatic DNMT3A and JAK2 mutations in a chronic phase polycythemia vera patient.
Polycythemia Vera
DNMT3A, TET2, and JAK2 mutations in polycythemia vera following long-term remission of secondary acute myeloid leukemia.
Polycythemia Vera
Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation.
Polyneuropathies
A Patient With DNMT1 Gene Mutation Presenting With Polyneuropathy, Hearing Loss, and Personality Changes.
Post-Concussion Syndrome
Reducing the time interval between concussion and voluntary exercise restores motor impairment, short-term memory, and alterations to gene expression.
Pre-Eclampsia
Dysregulated DNA Methyltransferase 3A Upregulates IGFBP5 to Suppress Trophoblast Cell Migration and Invasion in Preeclampsia.
Pre-Eclampsia
Induction of TGF-? receptor I expression in a DNA methylation-independent manner mediated by DNMT3A downregulation is involved in early-onset severe preeclampsia.
Pre-Eclampsia
Modulation of FABP4 hypomethylation by DNMT1 and its inverse interaction with miR-148a/152 in the placenta of preeclamptic rats and HTR-8 cells.
Pre-Eclampsia
Preeclampsia is associated with hypermethylation of IGF-1 promoter mediated by DNMT1.
Precancerous Conditions
Alterations in gene expression associated with the overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, during human hepatocarcinogenesis.
Precancerous Conditions
Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas.
Precancerous Conditions
Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis.
Precancerous Conditions
Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas.
Precancerous Conditions
Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
?-Arrestin1 promotes the self-renewal of the leukemia-initiating cell-enriched subpopulation in B-lineage acute lymphoblastic leukemia related to DNMT1 activity.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Clinicopathologic Effect of DNMT3A Mutation in Adult T-Cell Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cost-effective screening of DNMT3A coding sequence identifies somatic mutation in pediatric T-cell acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNA methyltransferase 3a hot-spot locus is not mutated in pediatric patients affected by acute myeloid or T-cell acute lymphoblastic leukemia: an Italian study.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNA methyltransferase expression differs with proliferation in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Dnmt3a haploinsufficiency cooperates with oncogenic Kras to promote an early-onset T-cell acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNMT3A mutation analysis in adult patients with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNMT3A mutation is associated with increased age and adverse outcome in adult T-acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNMT3A mutations and prognostic significance in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Downregulation of miR-217 correlates with resistance of ph(+) leukemia cells to ABL tyrosine kinase inhibitors.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Early T-cell precursor acute lymphoblastic leukemia with KRAS and DNMT3A mutations and unexpected monosomy 7.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Epigenetic alterations in hematopoietic malignancies.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Exosomal DNMT1 mRNA transcript is elevated in acute lymphoblastic leukemia which might reprograms leukemia progression.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Gene expression profiling of the DNMT3A R882 mutation in acute leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Patterns of DNMT1 Promoter Methylation in Patients with Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Tatton-Brown-Rahman syndrome: Six individuals with novel features.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The association of DNA methyltransferase 1 gene polymorphisms with susceptibility to childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The effects of clofarabine in ALL inhibition through DNA methylation regulation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
CDKN2B downregulation and other genetic characteristics in T-acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Clinicopathologic Effect of DNMT3A Mutation in Adult T-Cell Acute Lymphoblastic Leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Cost-effective screening of DNMT3A coding sequence identifies somatic mutation in pediatric T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Deleterious point mutations in T-cell acute lymphoblastic leukemia: Mechanistic insights into leukemogenesis.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Dnmt3a haploinsufficiency cooperates with oncogenic Kras to promote an early-onset T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
DNMT3A mutation analysis in adult patients with acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
DNMT3A mutation is associated with increased age and adverse outcome in adult T-acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Dnmt3a regulates T-cell development and suppresses T-ALL transformation.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Therapy-related acute lymphoblastic leukemia is a distinct entity with adverse genetic features and clinical outcomes.
Premature Birth
DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status.
Primary Myelofibrosis
Array comparative genomic hybridization and sequencing of 23 genes in 80 patients with myelofibrosis at chronic or acute phase.
Primary Myelofibrosis
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
Primary Myelofibrosis
DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms.
Primary Myelofibrosis
Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation.
Primary Myelofibrosis
Ruxolitinib in combination with DNA methyltransferase inhibitors: clinical responses in patients with symptomatic myelofibrosis with cytopenias and elevated blast(s) counts.
Prostatic Hyperplasia
Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications.
Prostatic Hyperplasia
Altered methylation of multiple genes in carcinogenesis of the prostate.
Prostatic Hyperplasia
Polymorphisms in the DNA methyltransferase 3b gene and prostate cancer risk.
Prostatic Intraepithelial Neoplasia
Altered methylation of multiple genes in carcinogenesis of the prostate.
Prostatic Intraepithelial Neoplasia
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Prostatic Intraepithelial Neoplasia
Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model.
Prostatic Neoplasms
5,6 Dihydro-5'-azacytidine (DHAC) restores androgen responsiveness in androgen-insensitive prostate cancer cells.
Prostatic Neoplasms
5-Aza-2'-deoxycytidine stress response and apoptosis in prostate cancer.
Prostatic Neoplasms
A feedback regulation between miR-145 and DNA methyltransferase 3b in prostate cancer cell and their responses to irradiation.
Prostatic Neoplasms
A novel DNA methyltransferase I-derived peptide eluted from soluble HLA-A*0201 induces peptide-specific, tumor-directed cytotoxic T cells.
Prostatic Neoplasms
Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications.
Prostatic Neoplasms
Activation of silenced tumor suppressor genes in prostate cancer cells by a novel energy restriction-mimetic agent.
Prostatic Neoplasms
Altered methylation of multiple genes in carcinogenesis of the prostate.
Prostatic Neoplasms
Antagonistic activities of miR-148a and DNMT1: Ectopic expression of miR-148a impairs DNMT1 mRNA and dwindle cell proliferation and survival.
Prostatic Neoplasms
Correlation between the expression of DNMT1, and GSTP1 and APC, and the methylation status of GSTP1 and APC in association with their clinical significance in prostate cancer.
Prostatic Neoplasms
CRISPR-Mediated Reactivation of DKK3 Expression Attenuates TGF-? Signaling in Prostate Cancer.
Prostatic Neoplasms
Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth.
Prostatic Neoplasms
DNA methyltransferase 3b (DNMT3b), tumor tissue DNA methylation, Gleason score, and prostate cancer mortality: investigating causal relationships.
Prostatic Neoplasms
DNMT1 and DNMT3B regulate tumorigenicity of human prostate cancer cells by controlling RAD9 expression through targeted methylation.
Prostatic Neoplasms
DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis.
Prostatic Neoplasms
DNMT1 silencing affects locus specific DNA methylation and increases prostate cancer derived PC3 cell invasiveness.
Prostatic Neoplasms
DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1.2 expression in spinal cord dorsal horn.
Prostatic Neoplasms
Effect of histone deacetylase and DNA methyltransferase inhibitors on the expression of the androgen receptor gene in androgen-independent prostate cancer cell lines.
Prostatic Neoplasms
Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells.
Prostatic Neoplasms
Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer.
Prostatic Neoplasms
Epigenetics and prostate cancer: defining the timing of DNA methyltransferase deregulation during prostate cancer progression.
Prostatic Neoplasms
Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer.
Prostatic Neoplasms
Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells.
Prostatic Neoplasms
EZH2 dependent H3K27me3 is involved in epigenetic silencing of ID4 in prostate cancer.
Prostatic Neoplasms
Frequent methylation of estrogen receptor in prostate cancer: correlation with tumor progression.
Prostatic Neoplasms
GSTP1 DNA methylation and expression status is indicative of 5-aza-2'-deoxycytidine efficacy in human prostate cancer cells.
Prostatic Neoplasms
Histone deacetylase and DNA methyltransferase in human prostate cancer.
Prostatic Neoplasms
HOTAIR-mediated reciprocal regulation of EZH2 and DNMT1 contribute to polyphyllin I-inhibited growth of castration-resistant prostate cancer cells in vitro and in vivo.
Prostatic Neoplasms
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Prostatic Neoplasms
Long non-coding RNA BLACAT1 inhibits prostate cancer cell proliferation through sponging miR-361.
Prostatic Neoplasms
Mahanine restores RASSF1A expression by down-regulating DNMT1 and DNMT3B in prostate cancer cells.
Prostatic Neoplasms
Mahanine reverses an epigenetically silenced tumor suppressor gene RASSF1A in human prostate cancer cells.
Prostatic Neoplasms
Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase.
Prostatic Neoplasms
Marginal Time-Dependent Causal Effects in Mediation Analysis With Survival Data.
Prostatic Neoplasms
Micro-ribonucleic acid 29b inhibits cell proliferation and invasion and enhances cell apoptosis and chemotherapy effects of cisplatin via targeting of DNMT3b and AKT3 in prostate cancer.
Prostatic Neoplasms
Milk disrupts p53 and DNMT1, the guardians of the genome: implications for acne vulgaris and prostate cancer.
Prostatic Neoplasms
Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.
Prostatic Neoplasms
Multi-target siRNA based on DNMT3A/B homologous conserved region influences cell cycle and apoptosis of human prostate cancer cell line TSU-PR1.
Prostatic Neoplasms
Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer.
Prostatic Neoplasms
Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer.
Prostatic Neoplasms
Polymorphisms in the DNA methyltransferase 3b gene and prostate cancer risk.
Prostatic Neoplasms
Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells.
Prostatic Neoplasms
Re: A Feedback Regulation between miR-145 and DNA Methyltransferase 3b in Prostate Cancer Cell and Their Responses to Irradiation.
Prostatic Neoplasms
REX-1 Represses RASSF1a and Activates the MEK/ERK Pathway to Promote Tumorigenesis in Prostate Cancer.
Prostatic Neoplasms
SChLAP1 promotes prostate cancer development through interacting with EZH2 to mediate promoter methylation modification of multiple miRNAs of chromosome 5 with a DNMT3a-feedback loop.
Prostatic Neoplasms
Single-nucleotide polymorphisms in DNMT3B gene and DNMT3B mRNA expression in association with prostate cancer mortality.
Prostatic Neoplasms
Specific zinc finger-induced methylation of PD-L1 promoter inhibits its expression.
Prostatic Neoplasms
Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model.
Prostatic Neoplasms
Targeting epigenetics for the treatment of prostate cancer: recent progress and future directions.
Prostatic Neoplasms
TGF-? regulates DNA methyltransferase expression in prostate cancer, correlates with aggressive capabilities, and predicts disease recurrence.
Prostatic Neoplasms
The DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer.
Prostatic Neoplasms
The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer.
Prostatic Neoplasms
Transcriptome analysis of human colon Caco-2 cells exposed to sulforaphane.
Prostatic Neoplasms
Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and Breast Cancer Cells: Implications for Therapeutic Targeting.
Prostatic Neoplasms
Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase.
Prostatic Neoplasms
[Polymorphisms of DNA methyltransferases and the risk of prostate cancer].
Protein Deficiency
Early-onset colorectal cancer: A distinct entity with unique genetic features.
Pseudomonas Infections
Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection.
Psoriasis
Polymorphisms in GNMT and DNMT3b are associated with methotrexate treatment outcome in plaque psoriasis.
Pulmonary Disease, Chronic Obstructive
Cigarette smoke extract promotes DNA methyltransferase 3a expression in dendritic cells, inducing Th-17/Treg imbalance via the c-Jun/allograft inflammatory factor 1 axis.
Pulmonary Disease, Chronic Obstructive
Hypomethylation of LINE-1 repeat elements and global loss of DNA hydroxymethylation in vapers and smokers.
Pulmonary Disease, Chronic Obstructive
Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model.
Pulmonary Disease, Chronic Obstructive
[Lung cancer and its epigenetics association with chronic obstructive pulmonary disease].
Purpura
Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura.
Purpura, Thrombocytopenic, Idiopathic
Association of DNA Methyltransferase 3B Promotor Polymorphism With Childhood Chronic Immune Thrombocytopenia.
Purpura, Thrombocytopenic, Idiopathic
Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura.
Purpura, Thrombocytopenic, Idiopathic
DNA methyltransferase 3B (DNMT3B -579G>T) promotor polymorphism and the susceptibility to pediatric immune thrombocytopenic purpura in Egypt.
Purpura, Thrombocytopenic, Idiopathic
DNA methyltransferase 3B gene promoter and interleukin-1 receptor antagonist polymorphisms in childhood immune thrombocytopenia.
Purpura, Thrombocytopenic, Idiopathic
DNMT3B 579G>T Promoter Polymorphism and the Risk for Idiopathic Thrombocytopenic Purpura in a Chinese Population.
Purpura, Thrombocytopenic, Idiopathic
DNMT3B promoter polymorphism and risk of immune thrombocytopenic purpura in pediatric Egyptians.
Purpura, Thrombocytopenic, Idiopathic
Role of DNA methyltransferase 3A mRNA expression in Egyptian patients with idiopathic thrombocytopenic purpura.
Purpura, Thrombocytopenic, Idiopathic
Single nucleotide polymorphism in DNMT3B promoter and the risk for idiopathic thrombocytopenic purpura in Chinese population.
Pyoderma Gangrenosum
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease.
Radiation Fibrosis Syndrome
DNA Methyltransferase Gene Polymorphisms for Prediction of Radiation-induced Skin Fibrosis after Treatment of Breast Cancer: a Multifactorial Genetic Approach.
Rectal Neoplasms
Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations.
Relapsing Fever
Characterization of a DNA Adenine Methyltransferase Gene of Borrelia hermsii and Its Dispensability for Murine Infection and Persistence.
Renal Insufficiency
Vesicourethral reflux-induced renal failure in a patient with ICF syndrome due to a novel DNMT3B mutation.
Reperfusion Injury
Untargeted DNA-Demethylation Therapy Neither Prevents Nor Attenuates Ischemia-Reperfusion-Induced Renal Fibrosis.
Retinal Degeneration
DNA methylation and differential gene regulation in photoreceptor cell death.
Retinitis Pigmentosa
Simultaneous Reprogramming and Gene Correction of Patient Fibroblasts.
Retinoblastoma
5-Aza-2''-deoxycytidine inhibits retinoblastoma cell by reactivating epigenetically silenced RASSF1A gene.
Retinoblastoma
Allosteric activator domain of maintenance human DNA (cytosine-5) methyltransferase and its role in methylation spreading.
Retinoblastoma
AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1.
Retinoblastoma
Association between human papillomavirus and Epstein - Barr virus DNA and gene promoter methylation of RB1 and CDH1 in the cervical lesions: a transversal study.
Retinoblastoma
De-regulated expression of the BRG1 chromatin remodeling factor in bone marrow mesenchymal stromal cells induces senescence associated with the silencing of NANOG and changes in the levels of chromatin proteins.
Retinoblastoma
Deoxyribonucleic acid methyltransferase 3B promotes epigenetic silencing through histone 3 chromatin modifications in pituitary cells.
Retinoblastoma
Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer.
Retinoblastoma
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.
Retinoblastoma
Down-regulation of DNMT3b in PC3 cells effects locus-specific DNA methylation, and represses cellular growth and migration.
Retinoblastoma
Epigenetic control of trefoil factor family (TFF) peptide expression in human retinoblastoma cell lines.
Retinoblastoma
Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway.
Retinoblastoma
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Retinoblastoma
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Retinoblastoma
Loss of RB compromises specific heterochromatin modifications and modulates HP1alpha dynamics.
Retinoblastoma
Overexpression of DNA methyltransferases 1, 3a, and 3b significantly correlates with retinoblastoma tumorigenesis.
Retinoblastoma
Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex.
Retinoblastoma
SUV39H1/DNMT3A-dependent methylation of the RB1 promoter stimulates PIN1 expression and melanoma development.
Retinoblastoma
The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity.
Retinoblastoma
[DNMT1 protein promotes retinoblastoma proliferation by silencing MEG3 gene].
Rett Syndrome
Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1.
Rett Syndrome
Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome.
Rhabdomyolysis
Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock.
Rhabdomyolysis
Therapeutic Effects of Procainamide on Endotoxin-Induced Rhabdomyolysis in Rats.
Rhabdomyosarcoma
Erratum: Increased DNA methyltransferase expression in rhabdomyosarcomas. Int. J. Cancer, 83, 10-14 (1999).
Rhabdomyosarcoma
Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma.
Rhabdomyosarcoma, Alveolar
Increased DNA methyltransferase expression in rhabdomyosarcomas.
Rhabdomyosarcoma, Alveolar
Molecular mechanisms of Guadecitabine induced FGFR4 down regulation in alveolar rhabdomyosarcomas.
Rhabdomyosarcoma, Embryonal
DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation.
Rheumatic Heart Disease
Coordination of PRKCA/PRKCA-AS1 interplay facilitates DNA methyltransferase 1 recruitment on DNA methylation to affect protein kinase C alpha transcription in mitral valve of rheumatic heart disease.
Rickets, Hypophosphatemic
Whole exome sequencing unravels disease-causing genes in consanguineous families in Qatar.
Salivary Gland Neoplasms
Immunolocalization of DNMT1 and DNMT3a in salivary gland neoplasms.
Sarcoma, Myeloid
Case report: Rare myeloid sarcoma development following renal transplantation with KRAS and DNMT3A gene mutations.
Scleroderma, Systemic
TGF?-induced epigenetic deregulation of SOCS3 facilitates STAT3-signaling to promote fibrosis.
Seizures
Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.
Seizures
Methyl-CpG-Binding Domain Protein 3 Promotes Seizures by Recruiting Methyltransferase DNMT1 to Enhance TREM2 Methylation.
Seizures, Febrile
DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures.
Seminoma
Differential expression of DNA methyltransferases and demethylases among the various testicular germ cell tumor subtypes.
Seminoma
DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma.
Seminoma
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.
Seminoma
DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer.
Seminoma
Gene expression profiling identifies a set of transcripts that are up-regulated inhuman testicular seminoma.
Seminoma
Genome-wide expression profiling reveals new insights into pathogenesis and progression of testicular germ cell tumors.
Sepsis
Genetic variation of DNA methyltransferase-3A contributes to protection against persistent MRSA bacteremia in patients.
Severe Combined Immunodeficiency
DNMT3B deficiency presenting as severe combined immune deficiency: A case report.
Severe Combined Immunodeficiency
Simultaneous Reprogramming and Gene Correction of Patient Fibroblasts.
Shock, Septic
Circulating extracellular vesicle content reveals de novo DNA methyltransferase expression as a molecular method to predict septic shock.
Skin Diseases
Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.
Skin Diseases
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease.
Sleep Deprivation
Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation.
Sleep Deprivation
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Small Cell Lung Carcinoma
Combinations of DNA methyltransferase and histone deacetylase inhibitors induce DNA damage in small cell lung cancer cells: correlation of resistance with IFN-stimulated gene expression.
Small Cell Lung Carcinoma
H3K27me3 induces multidrug resistance in small cell lung cancer by affecting HOXA1 DNA methylation via regulation of the lncRNA HOTAIR.
Small Cell Lung Carcinoma
Prognostic significance of folate metabolism polymorphisms for lung cancer.
Smoldering Multiple Myeloma
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Sotos Syndrome
Co-occurrence of a maternally inherited DNMT3A duplication and a paternally inherited pathogenic variant in EZH2 in a child with growth retardation and severe short stature: atypical Weaver syndrome or evidence of a DNMT3A dosage effect?
Spasms, Infantile
Identification of De Novo DNMT3A Mutations That Cause West Syndrome by Using Whole-Exome Sequencing.
Spinocerebellar Ataxias
Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline.
Spinocerebellar Ataxias
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Spondylitis, Ankylosing
Evaluation of DNMT1 gene expression profile and methylation of its promoter region in patients with ankylosing spondylitis.
Squamous Cell Carcinoma of Head and Neck
A novel C/T polymorphism in the core promoter of human de novo cytosine DNA methyltransferase 3B6 is associated with prognosis in head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
Analysis of Association Between MGMT and p53 Gene Single Nucleotide Polymorphisms and Laryngeal Cancer.
Squamous Cell Carcinoma of Head and Neck
Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis.
Squamous Cell Carcinoma of Head and Neck
DNA methylation-mediated Klotho silencing is an independent prognostic biomarker of head and neck squamous carcinoma.
Squamous Cell Carcinoma of Head and Neck
DNA methyltransferase 3B -149C/T polymorphism and the risk of laryngeal squamous cell carcinoma: a case-control study.
Squamous Cell Carcinoma of Head and Neck
DNMT1 Enhances the Radiosensitivity of HPV-Positive Head and Neck Squamous Cell Carcinomas via Downregulating SMG1.
Squamous Cell Carcinoma of Head and Neck
Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival.
Squamous Cell Carcinoma of Head and Neck
Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Epigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer.
Squamous Cell Carcinoma of Head and Neck
FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
Squamous Cell Carcinoma of Head and Neck
Gene signatures of m5C regulators may predict prognoses of patients with head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
High DNMT1 Is Associated With Worse Local Control in Early-Stage Laryngeal Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis in Head and Neck Squamous Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Identification of Expression Patterns and Potential Prognostic Significance of m5C-Related Regulators in Head and Neck Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Immunohistochemical evaluation of Klotho and DNA methyltransferase 3a in oral squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
Natural Compounds: DNA Methyltransferase Inhibitors in Oral Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Noninvasive Molecular Detection of Head and Neck Squamous Cell Carcinoma: An Exploratory Analysis.
Squamous Cell Carcinoma of Head and Neck
Over-expression of DNA methyltransferases and CDKN2A gene methylation status in squamous cell carcinoma of the oral cavity.
Squamous Cell Carcinoma of Head and Neck
Overexpression of Sal-like protein 4 in head and neck cancer: epigenetic effects and clinical correlations.
Squamous Cell Carcinoma of Head and Neck
Promoter polymorphisms of DNMT3B and the risk of head and neck squamous cell carcinoma in Taiwan: a case-control study.
Squamous Cell Carcinoma of Head and Neck
RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner.
Squamous Cell Carcinoma of Head and Neck
The clinical significance of methylation of MAGE-A1 and-A3 promoters and expression of DNA methyltransferase in patients with laryngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
The involvement of promoter methylation and DNA methyltransferase-1 in the regulation of EpCAM expression in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Transfer RNA methyltransferase gene NSUN2 mRNA expression modifies the effect of T cell activation score on patient survival in head and neck squamous carcinoma.
Squamous Cell Carcinoma of Head and Neck
[The expression of DNMT1 in laryngeal squamous cell carcinoma and its clinical significance].
Starvation
A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity.
Starvation
Modulation of DNA methyltransferase profile by methyl donor starvation followed by gamma irradiation.
Stomach Neoplasms
5-Aza-2'-deoxycitydine induces demethylation and up-regulates transcription of p16INK4A gene in human gastric cancer cell lines.
Stomach Neoplasms
A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma.
Stomach Neoplasms
A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk.
Stomach Neoplasms
Aberrant methylation of integrin alpha4 gene in human gastric cancer cells.
Stomach Neoplasms
AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity.
Stomach Neoplasms
APC gene is modulated by hsa-miR-135b-5p in both diffuse and intestinal gastric cancer subtypes.
Stomach Neoplasms
Association between human papillomavirus and Epstein - Barr virus DNA and gene promoter methylation of RB1 and CDH1 in the cervical lesions: a transversal study.
Stomach Neoplasms
Association of DNMT3B -283T>C polymorphism with risk of lung and gastric cancer: a case-control study and a meta-analysis.
Stomach Neoplasms
Association of five genetic variations in DNMT1 and DNMT3A with gastric cancer in a Chinese population.
Stomach Neoplasms
Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan.
Stomach Neoplasms
Association of NDRG1 Gene Promoter Methylation with Reduced NDRG1 Expression in Gastric Cancer Cells and Tissue Specimens.
Stomach Neoplasms
Association of the DNMT3A -448A>G polymorphism with genetic susceptibility to colorectal cancer.
Stomach Neoplasms
Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer.
Stomach Neoplasms
Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis.
Stomach Neoplasms
Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, affecting cell migration and invasion in gastric cancer.
Stomach Neoplasms
DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer.
Stomach Neoplasms
DNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27/H3K9 methylation in EMT-related metastasis of gastric cancer.
Stomach Neoplasms
DNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18INK4C in gastric carcinogenesis.
Stomach Neoplasms
DNA methyltransferase 3a rs1550117 genetic polymorphism predicts poor survival in gastric cancer patients.
Stomach Neoplasms
DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers.
Stomach Neoplasms
DNA methyltransferase inhibitor 5-aza-CdR enhances the radiosensitivity of gastric cancer cells.
Stomach Neoplasms
DNA methyltransferase3a expression is an independent poor prognostic indicator in gastric cancer.
Stomach Neoplasms
DNMT1 overexpression predicting gastric carcinogenesis, subsequent progression and prognosis: a meta and bioinformatic analysis.
Stomach Neoplasms
DNMT1 silencing affects locus specific DNA methylation and increases prostate cancer derived PC3 cell invasiveness.
Stomach Neoplasms
DNMT1, DNMT3A and DNMT3B Polymorphisms Associated With Gastric Cancer Risk: A Systematic Review and Meta-analysis.
Stomach Neoplasms
DNMT3a rs1550117 polymorphism association with increased risk of Helicobacter pylori infection.
Stomach Neoplasms
DNMT3A rs36012910 A>G polymorphism and gastric cancer susceptibility in a Chinese population.
Stomach Neoplasms
DNMT3A-mediated down-regulation of microRNA-105 promotes gastric cancer cell proliferation.
Stomach Neoplasms
DNMT3B -149 C>T and -579 G>T Polymorphisms and Risk of Gastric and Colorectal Cancer: a Meta-analysis.
Stomach Neoplasms
DNMT3B -579 G>T Promoter Polymorphism and the Risk of Gastric Cancer in the West of Iran.
Stomach Neoplasms
Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma.
Stomach Neoplasms
E-cadherin gene promoter hypermethylation in H. pylori-induced enlarged fold gastritis.
Stomach Neoplasms
Effect of DNMT3A polymorphisms on CpG island hypermethylation in gastric mucosa.
Stomach Neoplasms
Epigenetically deregulated miR-200c is involved in a negative feedback loop with DNMT3a in gastric cancer cells.
Stomach Neoplasms
Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer.
Stomach Neoplasms
Expression of human histo-blood group ABO genes is dependent upon DNA methylation of the promoter region.
Stomach Neoplasms
Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma.
Stomach Neoplasms
FOXC2-AS1 stabilizes FOXC2 mRNA via association with NSUN2 in gastric cancer cells.
Stomach Neoplasms
Functional analysis of the NH2-terminal hydrophobic region and BRICHOS domain of GKN1.
Stomach Neoplasms
Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NF?B pathway in gastric cancer development.
Stomach Neoplasms
Hypermethylation downregulates Runx3 gene expression and its restoration suppresses gastric epithelial cell growth by inducing p27 and caspase3 in human gastric cancer.
Stomach Neoplasms
Immunohistochemical analysis of polycomb group protein expression in advanced gastric cancer.
Stomach Neoplasms
Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers.
Stomach Neoplasms
Inhibition of DNA methyltransferase by antisense oligodeoxynucleotide modifies cell characteristics in gastric cancer cell lines.
Stomach Neoplasms
Interaction between DNMT3B and MYH11 via hypermethylation regulates gastric cancer progression.
Stomach Neoplasms
Lack of effects of single nucleotide polymorphisms of the DNA methyltransferase 1 gene on gastric cancer in Iranian patients: a case control study.
Stomach Neoplasms
LINC00240 promotes gastric cancer cell proliferation, migration and EMT via the miR-124-3p / DNMT3B axis.
Stomach Neoplasms
Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer.
Stomach Neoplasms
LncRNA HOXA11-AS Promotes Proliferation and Invasion of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1.
Stomach Neoplasms
LncRNA-SNHG1 contributes to gastric cancer cell proliferation by regulating DNMT1.
Stomach Neoplasms
Long noncoding RNA LINC00673 epigenetically suppresses KLF4 by interacting with EZH2 and DNMT1 in gastric cancer.
Stomach Neoplasms
Loss of expression of DNA repair enzymes MGMT, hMLH1, and hMSH2 during tumor progression in gastric cancer.
Stomach Neoplasms
MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome.
Stomach Neoplasms
Methylation-induced downregulation and tumor suppressive role of microRNA-29b in gastric cancer through targeting LASP1.
Stomach Neoplasms
MicroRNA-148a can regulate runt-related transcription factor 3 gene expression via modulation of DNA methyltransferase 1 in gastric cancer.
Stomach Neoplasms
MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer.
Stomach Neoplasms
MiR-143 inhibits cell proliferation and invasion by targeting DNMT3A in gastric cancer.
Stomach Neoplasms
MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1.
Stomach Neoplasms
miR-148a suppresses cell invasion and migration in gastric cancer by targeting DNA methyltransferase 1.
Stomach Neoplasms
miR-492 promotes chemoresistance to CDDP and metastasis by targeting inhibiting DNMT3B and induces stemness in gastric cancer.
Stomach Neoplasms
Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers.
Stomach Neoplasms
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Stomach Neoplasms
Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma.
Stomach Neoplasms
No evidence of correlation between the single nucleotide polymorphism of DNMT3B promoter and gastric cancer risk in a Japanese population.
Stomach Neoplasms
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.
Stomach Neoplasms
P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib.
Stomach Neoplasms
Peperomin E Induces Promoter Hypomethylation of Metastatic-Suppressor Genes and Attenuates Metastasis in Poorly Differentiated Gastric Cancer.
Stomach Neoplasms
Polymorphism of DNA Methyltransferase 3b and Association with Development and Prognosis in Gastric Cancer.
Stomach Neoplasms
Polymorphisms of the DNA methyltransferase 1 associated with reduced risks of Helicobacter pylori infection and increased risks of gastric atrophy.
Stomach Neoplasms
Polymorphisms of the DNA Methyltransferase 1 Gene Predict Survival of Gastric Cancer Patients Receiving Tumorectomy.
Stomach Neoplasms
Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy.
Stomach Neoplasms
Protein expression and promoter methylation of the candidate biomarker TCF21 in gastric cancer.
Stomach Neoplasms
Protein expression trends of DNMT1 in gastrointestinal diseases: From benign to precancerous lesions to cancer.
Stomach Neoplasms
Reactivation of Atp4a concomitant with intragenic DNA demethylation for cancer inhibition in a gastric cancer model.
Stomach Neoplasms
RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner.
Stomach Neoplasms
The DNA methyltransferase inhibitor zebularine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo.
Stomach Neoplasms
The DNMT3B -579G>T Polymorphism Is Significantly Associated With the Risk of Gastric Cancer but not Lung Cancer in Chinese Population.
Stomach Neoplasms
The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer.
Stomach Neoplasms
Tumor-Associated Macrophages Promote Epigenetic Silencing of Gelsolin through DNA Methyltransferase 1 in Gastric Cancer Cells.
Stomach Neoplasms
[Effects of dnmt1 Gene Silencing on Cell Cycle, Proliferation, and Apoptosis of Gastric Cancer Cell Line AGS.]
Stomach Neoplasms
[Effects of pshRNA-DNMT1 on the proliferation and apoptosis of gastric cancer: experiments in vitro and in vivo]
Stomach Neoplasms
[Relationship between Runx3 gene expression and its DNA methylation in gastric cancer]
Stroke
Effect of Inhibition of DNA Methylation Combined with Task-Specific Training on Chronic Stroke Recovery.
Stroke
Emerging role of epigenetics in stroke: part 1: DNA methylation and chromatin modifications.
Stroke
Genomic Profiling of a Randomized Trial of Interferon-? versus Hydroxyurea in MPN Reveals Mutation-Specific Responses.
Sweet Syndrome
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease.
Teratocarcinoma
Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives.
Teratocarcinoma
Endogenous assays of DNA methyltransferases: Evidence for differential activities of DNMT1, DNMT2, and DNMT3 in mammalian cells in vivo.
Teratocarcinoma
Interference with DNA methyltransferase activity and genome methylation during F9 teratocarcinoma stem cell differentiation induced by polyamine depletion.
Teratoma
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.
Teratoma
Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b.
Testicular Neoplasms
DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer.
Testicular Neoplasms
microRNA-199a-3p, DNMT3A, and aberrant DNA methylation in testicular cancer.
Tetralogy of Fallot
Association between mRNA levels of DNMT1, DNMT3A, DNMT3B, MBD2 and LINE-1 methylation status in infants with tetralogy of Fallot.
Thrombosis
Risk factors of thrombosis in Chinese subjects with acute promyelocytic leukemia.
Thrombosis
[Gene expressions of DNA methyltransferase 1 and human leukocyte antigen-DRalpha in hepatocelluar carcinoma and their clinical significance.]
Thymoma
Association of the DNMT3B -579G>T polymorphism with risk of thymomas in patients with myasthenia gravis.
Thymoma
Codelivery of Genistein and miRNA-29b to A549 Cells Using Aptamer-Hybrid Nanoparticle Bioconjugates.
Thymoma
Downregulation of DNMT3a expression by RNAi and its effect on NF-?Bs expression of thymic epithelial cells.
Thymus Neoplasms
Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis.
Thyroid Cancer, Papillary
LncRNA LINC00673 inhibits p53 expression by interacting with EZH2 and DNMT1 in papillary thyroid carcinoma.
Thyroid Cancer, Papillary
Novel DNMT3A Germline Variant in a Patient with Multiple Paragangliomas and Papillary Thyroid Carcinoma.
Thyroid Cancer, Papillary
Prognostic significance of DNMT3A alterations in Middle Eastern papillary thyroid carcinoma.
Thyroid Cancer, Papillary
Shikonin Inhibites Migration and Invasion of Thyroid Cancer Cells by Downregulating DNMT1.
Thyroid Cancer, Papillary
The Suppression of miR-199a-3p by Promoter Methylation Contributes to Papillary Thyroid Carcinoma Aggressiveness by Targeting RAP2a and DNMT3a.
Thyroid Diseases
Alterations of Global DNA Methylation and DNA Methyltransferase Expression in T and B Lymphocytes from Patients with Newly Diagnosed Autoimmune Thyroid Diseases After Treatment: A Follow-Up Study.
Thyroid Diseases
Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease.
Thyroid Diseases
Gene-gene and gene-sex epistatic interactions of DNMT1, DNMT3A and DNMT3B in autoimmune thyroid disease.
Thyroid Neoplasms
Liquid Biopsy as a Minimally Invasive Source of Thyroid Cancer Genetic and Epigenetic Alterations.
Thyroid Neoplasms
Mutations of genes including DNMT3A detected by next-generation sequencing in thyroid cancer.
Thyroid Neoplasms
Shikonin Inhibites Migration and Invasion of Thyroid Cancer Cells by Downregulating DNMT1.
Thyroid Neoplasms
Thyroid cancer 1 (C8orf4) shows high expression, no mutation and reduced methylation level in lung cancers, and its expression correlates with ?-catenin and DNMT1 expression and poor prognosis.
Tics
DAXX Suppresses Tumor-Initiating Cells in Estrogen Receptor-positive Breast Cancer following endocrine therapy.
Tics
Human ovarian cancer intrinsic mechanisms regulate lymphocyte activation in response to immune checkpoint blockade.
Transposition of Great Vessels
DNA methyltransferase 1 rs16999593 genetic polymorphism decreases risk in patients with transposition of great arteries.
Triple Negative Breast Neoplasms
5-AZA-dC induces epigenetic changes associated with modified glycosylation of secreted glycoproteins and increased EMT and migration in chemo-sensitive cancer cells.
Triple Negative Breast Neoplasms
DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine.
Triple Negative Breast Neoplasms
DNMT1: A key drug target in triple-negative breast cancer.
Triple Negative Breast Neoplasms
Dysregulation of the epigenome in human breast cancer: contributions of gene-specific DNA hypermethylation to breast cancer pathobiology and targeting the breast cancer methylome for improved therapy.
Triple Negative Breast Neoplasms
Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells.
Triple Negative Breast Neoplasms
Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors.
Triple Negative Breast Neoplasms
Inhibition of DNMT1 and ERR? crosstalk suppresses breast cancer via derepression of IRF4.
Triple Negative Breast Neoplasms
miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer.
Triple Negative Breast Neoplasms
MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer.
Triple Negative Breast Neoplasms
SAHA and EGCG Promote Apoptosis in Triple-negative Breast Cancer Cells, Possibly Through the Modulation of cIAP2.
Triple Negative Breast Neoplasms
YY1-mediated long non-coding RNA Kcnq1ot1 promotes the tumor progression by regulating PTEN via DNMT1 in triple negative breast cancer.
Tuberculosis
DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis.
Tuberculosis
Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection.
Tuberculosis
MamA essentiality in Mycobacterium smegmatis is explained by the presence of an apparent cognate restriction endonuclease.
Urinary Bladder Neoplasms
5-Aza-2'-Deoxycytidine Enhances Maspin Expression and Inhibits Proliferation, Migration, and Invasion of the Bladder Cancer T24 Cell Line.
Urinary Bladder Neoplasms
A novel regulatory circuit of miR?152 and DNMT1 in human bladder cancer.
Urinary Bladder Neoplasms
Angiogenin contributes to bladder cancer tumorigenesis by DNMT3b-mediated MMP2 activation.
Urinary Bladder Neoplasms
CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.
Urinary Bladder Neoplasms
Combination of Decitabine and Entinostat Synergistically Inhibits Urothelial Bladder Cancer Cells via Activation of FoxO1.
Urinary Bladder Neoplasms
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma.
Urinary Bladder Neoplasms
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells.
Urinary Bladder Neoplasms
DNMT1-dependent suppression of microRNA424 regulates tumor progression in human bladder cancer.
Urinary Bladder Neoplasms
DNMT1: An emerging target in the treatment of invasive urinary bladder cancer.
Urinary Bladder Neoplasms
DNMT3B silencing suppresses migration and invasion by epigenetically promoting miR-34a in bladder cancer.
Urinary Bladder Neoplasms
Effects on biological behavior of bladder carcinoma T24 cells via silencing DNMT1 and/or DNMT3b with shRNA In Vitro.
Urinary Bladder Neoplasms
Expression and function role of DNA methyltransferase 1 in human bladder cancer.
Urinary Bladder Neoplasms
Gene Expression, DNA Methylation and Prognostic Significance of DNA Repair Genes in Human Bladder Cancer.
Urinary Bladder Neoplasms
Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer.
Urinary Bladder Neoplasms
Identification and characterization of DNAzymes targeting DNA methyltransferase I for suppressing bladder cancer proliferation.
Urinary Bladder Neoplasms
Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder.
Urinary Bladder Neoplasms
Inhibition of bladder cancer invasion by Sp1-mediated BTG2 expression via inhibition of DNA methyltransferase 1.
Urinary Bladder Neoplasms
Kaempferol Modulates DNA Methylation and Downregulates DNMT3B in Bladder Cancer.
Urinary Bladder Neoplasms
Long non-coding RNA DBCCR1-003 regulate the expression of DBCCR1 via DNMT1 in bladder cancer.
Urinary Bladder Neoplasms
microRNA-451a promoter methylation regulated by DNMT3B expedites bladder cancer development via the EPHA2/PI3K/AKT axis.
Urinary Bladder Neoplasms
MiR-124-3p suppresses bladder cancer by targeting DNA methyltransferase 3B.
Urinary Bladder Neoplasms
miR-148a dependent apoptosis of bladder cancer cells is mediated in part by the epigenetic modifier DNMT1.
Urinary Bladder Neoplasms
miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.
Urinary Bladder Neoplasms
Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation.
Urinary Bladder Neoplasms
Prognostic value of opioid binding protein/cell adhesion molecule-like promoter methylation in bladder carcinoma.
Urinary Bladder Neoplasms
Regulation of SLD5 gene expression by miR-370 during acute growth of cancer cells.
Urinary Bladder Neoplasms
The effect of heat shock protein 90 inhibitors on histone 4 lysine 20 methylation in bladder cancer.
Urinary Bladder Neoplasms
Tobacco-Specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer.
Urinary Bladder Neoplasms
[Effect of stable DNA methyltransferase 3bknockdown on proliferation and apoptosis in bladder cancer cells in vitro].
Urinary Bladder Neoplasms
[Expression of DNMT3b in human bladder cancer tissue and its correlation with clinical prognosis].
Urogenital Neoplasms
Does Wnt/?-catenin pathway contribute to the stability of DNMT1 expression in urological cancer cell lines?
Urologic Neoplasms
Does Wnt/?-catenin pathway contribute to the stability of DNMT1 expression in urological cancer cell lines?
Urologic Neoplasms
Manipulating the epigenome for the treatment of urological malignancies.
Uterine Cervical Neoplasms
Aberrant methylation-mediated downregulation of lncRNA CCND2 AS1 promotes cell proliferation in cervical cancer.
Uterine Cervical Neoplasms
Aberrant Promoter Methylation and Expression of UTF1 during Cervical Carcinogenesis.
Uterine Cervical Neoplasms
CDH1 and SNAI1 are regulated by E7 from human papillomavirus types 16 and 18.
Uterine Cervical Neoplasms
Combined inhibition of JAK1/2 and DNMT1 by newly identified small-molecule compounds synergistically suppresses the survival and proliferation of cervical cancer cells.
Uterine Cervical Neoplasms
Crosstalk between histone modification and DNA methylation orchestrates the epigenetic regulation of the costimulatory factors, Tim?3 and galectin?9, in cervical cancer.
Uterine Cervical Neoplasms
Differential expression of Oct4 in HPV-positive and HPV-negative cervical cancer cells is not regulated by DNA methyltransferase 3A.
Uterine Cervical Neoplasms
DNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A.
Uterine Cervical Neoplasms
E-cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours.
Uterine Cervical Neoplasms
Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells.
Uterine Cervical Neoplasms
Enhanced anticancer effects of a methylation inhibitor by inhibiting a novel DNMT1 target, CEP 131, in cervical cancer.
Uterine Cervical Neoplasms
Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways.
Uterine Cervical Neoplasms
Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer.
Uterine Cervical Neoplasms
Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization.
Uterine Cervical Neoplasms
HDAC1/DNMT3A-Containing Complex Is Associated with Suppression of Oct4 in Cervical Cancer Cells.
Uterine Cervical Neoplasms
Histone deacetylase inhibitor apicidin downregulates DNA methyltransferase 1 expression and induces repressive histone modifications via recruitment of corepressor complex to promoter region in human cervix cancer cells.
Uterine Cervical Neoplasms
Histone deacetylase inhibitors inducing human cervical cancer cell apoptosis by decreasing DNA-methyltransferase 3B.
Uterine Cervical Neoplasms
HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53.
Uterine Cervical Neoplasms
HPV16 activates the promoter of Oct4 gene by sequestering HDAC1 from repressor complex to target it to proteasomal degradation.
Uterine Cervical Neoplasms
Human papillomavirus type 16 E6 suppresses microRNA-23b expression in human cervical cancer cells through DNA methylation of the host gene C9orf3.
Uterine Cervical Neoplasms
Impact of viral and host DNA methylations on HPV16-related cervical cancer pathogenesis.
Uterine Cervical Neoplasms
Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation.
Uterine Cervical Neoplasms
LINP1 promotes the progression of cervical cancer by scaffolding EZH2, LSD1, and DNMT1 to inhibit the expression of KLF2 and PRSS8.
Uterine Cervical Neoplasms
LncRNATCF7 up-regulates DNMT1 mediated by HPV-18 E6 and regulates biological behavior of cervical cancer cells by inhibiting miR-155.
Uterine Cervical Neoplasms
Methyl Donor Status Influences DNMT Expression and Global DNA Methylation in Cervical Cancer Cells.
Uterine Cervical Neoplasms
MicroRNA-148a-3p inhibits the proliferation of cervical cancer cells by regulating the expression levels of DNMT1 and UTF1.
Uterine Cervical Neoplasms
miR-182 induces cervical cancer cell apoptosis through inhibiting the expression of DNMT3a.
Uterine Cervical Neoplasms
MiR-29a inhibits invasion and metastasis of cervical cancer via modulating methylation of tumor suppressor SOCS1.
Uterine Cervical Neoplasms
MiR-375 Is Epigenetically Downregulated by HPV-16 E6 Mediated DNMT1 Upregulation and Modulates EMT of Cervical Cancer Cells by Suppressing lncRNA MALAT1.
Uterine Cervical Neoplasms
Reprogramming of HeLa cells upon DNMT3L overexpression mimics carcinogenesis.
Uterine Cervical Neoplasms
Retraction: MiR-375 Is Epigenetically Downregulated by HPV-16 E6 Mediated DNMT1 Upregulation and Modulates EMT of Cervical Cancer Cells by Suppressing lncRNA MALAT1.
Uterine Cervical Neoplasms
Sulforaphane Reverses the Expression of Various Tumor Suppressor Genes by Targeting DNMT3B and HDAC1 in Human Cervical Cancer Cells.
Uterine Cervical Neoplasms
SUV39H1-DNMT3A-mediated epigenetic regulation of Tim-3 and galectin-9 in the cervical cancer.
Uterine Cervical Neoplasms
SUV39H1-Mediated DNMT1 is Participated in the Epigenetic Regulation of Smad3 in Cervical Cancer.
Uterine Cervical Neoplasms
The 46359CT polymorphism of DNMT3B is associated with the risk of cervical cancer.
Uterine Cervical Neoplasms
The role of ADCYAP1, adenylate cyclase activating polypeptide 1, as a methylation biomarker for the early detection of cervical cancer.
Uterine Cervical Neoplasms
Trichosanthin inhibits DNA methyltransferase and restores methylation-silenced gene expression in human cervical cancer cells.
Uterine Cervical Neoplasms
[Effect of DNA methyltransferase 1 and methyl-CpG-binding protein 2 abnormal expression on cervical lesions and related interaction].
Uterine Cervical Neoplasms
[Effect of DNA methyltransferase 1 gene silencing on proliferation and apoptosis of HeLa cells]
Uterine Cervical Neoplasms
[Effect of folate in modulating the expression of DNA methyltransferase 1 and methyl-CpG-bingding protein 2 in cervical cancer cell lines].
Uterine Cervical Neoplasms
[Effect of folic acid and DNA methyltransferase 1 on cervical cancer and its precancerous lesion].
Varicocele
Increased de novo DNA Methylation Enzymes in Sperm of Individuals with Varicocele.
Vascular Diseases
Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD: JACC Review Topic of the Week.
Virus Diseases
DNA methylation by DNA methyltransferase 1 is critical for effector CD8 T cell expansion.
Virus Diseases
DNA methyltransferase induced by PBCV-1 virus infection of a Chlorella-like green alga.
Virus Diseases
Epigenetic changes mediated by microRNA miR29 activate cyclooxygenase 2 and lambda-1 interferon production during viral infection.
Virus Diseases
Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway.
Virus Diseases
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection.
Virus Diseases
Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling.
Virus Diseases
T Cell Exhaustion: An Epigenetically Imprinted Phenotypic and Functional Makeover.
Virus Diseases
The DNA methyltranferase Dnmt2 participates in RNA processing during cellular stress.
Virus Diseases
The Roles of Host 5-Methylcytosine RNA Methyltransferases during Viral Infections.
Virus Diseases
Up-regulation of microRNA-203 in influenza A virus infection inhibits viral replication by targeting DR1.
von Hippel-Lindau Disease
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Williams Syndrome
Metastasis-related methyltransferase 1 (Merm1) represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation.
Wilms Tumor
circ0093740 Promotes Tumor Growth and Metastasis by Sponging miR-136/145 and Upregulating DNMT3A in Wilms Tumor.
Wilms Tumor
Clonal Cytopenia of Undetermined Significance in a Patient with Congenital Wilms' Tumor 1 and Acquired DNMT3A Gene Mutations.
Wilms Tumor
Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A.
Xeroderma Pigmentosum
DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang, China.
Xeroderma Pigmentosum
DNA repair gene polymorphisms and risk of second primary neoplasms and mortality in oral cancer patients.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
Michaelis-Menten kinetics, Dnmt1 allosteric regulation mechanism, modelling, overview
-
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
inhibition by mechanism-based inhibitors and kinetics, detailed overview
-
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.045
1-deaza-S-adenosyl-L-homocysteine
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0029
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0025
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.021
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.075
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methoxy-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.006
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methyl-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.216
2-amino-4-[([(2S,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-3,4-dihydroxytetrahydrofuran-2-yl]methyl)sulfanyl]butanoic acid
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.045
3-deaza-S-adenosyl-L-homocysteine
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.008
8-aza-S-adenosyl-L-homocysteine
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0067
S-(N-(2-biphenyl-4-ylethyl)-2-chloroadenosyl)-L-homocysteine
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0054
S-(N-(2-biphenyl-4-ylethyl)adenosyl)-L-homocysteine
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.018
S-(N-(3,5-dimethoxybenzyl)adenosyl)-L-homocysteine
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.022
S-(N-(pyridin-4-ylmethyl)adenosyl)-L-homocysteine
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.061
S-(N-benzyladenosyl)-L-homocysteine
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.154
S-(N-phenyladenosyl)-L-homocysteine
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.027
S-(N-phenylethyladenosyl)-L-homocysteine
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0074
S-(N-phenylpropyladenosyl)-L-homocysteine
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.002
S-adenosyl-L-homocysteine
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
1
S-inosinylhomocysteine
Homo sapiens
IC50 above 1 mM, isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.3
S-nebularinehomocysteine
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0015
S-Tubercidinylhomocysteine
Homo sapiens
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0572
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0068
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.256
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.001
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methyl-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.5
2-amino-4-[([(2S,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-3,4-dihydroxytetrahydrofuran-2-yl]methyl)sulfanyl]butanoic acid
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.045
S-(1-deazaadenosyl)-L-homocysteine
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0068
S-(3-deazaadenosyl)-L-homocysteine
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.003
S-(8-azaadenosyl)-L-homocysteine
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.029
S-(N-(2-biphenyl-4-ylethyl)-2-chloroadenosyl)-L-homocysteine
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0006
S-(N-(2-biphenyl-4-ylethyl)adenosyl)-L-homocysteine
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0009
S-(N-(3,5-dimethoxybenzyl)adenosyl)-L-homocysteine
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0036
S-(N-(pyridin-4-ylmethyl)adenosyl)-L-homocysteine
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.001
S-(N-benzyladenosyl)-L-homocysteine
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.002
S-(N-phenyladenosyl)-L-homocysteine
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.002
S-(N-phenylethyladenosyl)-L-homocysteine
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0006
S-(N-phenylpropyladenosyl)-L-homocysteine
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0003
S-adenosyl-L-homocysteine
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
1
S-inosinylhomocysteine
Homo sapiens
IC50 above 1 mM, isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.028
S-nebularinehomocysteine
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
0.0003
S-Tubercidinylhomocysteine
Homo sapiens
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
pleomorphic adenoma, adenoid cystic carcinoma, mucoepidermoid carcinoma and polymorphous low-grade adenocarcinoma of lower lip, buccal mucosa, mandible, tongue, floor, or palate. Positive nuclear and cytoplasmic labeling for DNMT1 occurs in all samples, positive nuclear labeling for DNMT3a occurs only in few neoplasms: 1 pleomorphic adenoma, 2 adenoid cystic carcinoma and 1 mucoepidermoid cases, immunohistochemical
brenda
-
CD4+, ranscript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus, an autoimmune disease with CD4+ T cells with hypomethylated DNA. It is possible that patients are reacting indirectly to an underlying DNA hypomethylation status by increasing the mRNA levels of DNA methyltransferases when the disease is definitely active, overview
brenda
-
B lymphoblast cell line containing wild-type p53. The interaction between p53 and DNMT1 controls DNA methylation of the p16ink4A promoter that consequently reduces the level of the p16ink4A
brenda
-
B lymphoblast cell line with mutant p53. Mutant p53 loses its ability to suppress DNMT1 expression, and thus enhances methylation levels of the p16ink4A promoter and subsequently down-regulates p16ink4A protein
brenda
additional information
additional information
-
DNMTs are overexpressed in tumorigenic cell lines and in a few types of human neoplasms
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
subcellular localization of DNMT1 can be altered by the addition of IL-6, increasing the rate of nuclear translocation of the enzyme from the cytosolic compartment. The mechanism of nuclear translocation of DNMT1 is greatly enhanced by phosphorylation of the DNMT1 nuclear localization signal (NLS) by PKB/AKT kinase
brenda
-
subcellular localization of DNMT1 can be altered by the addition of IL-6, increasing the rate of nuclear translocation of the enzyme from the cytosolic compartment. The mechanism of nuclear translocation of DNMT1 is greatly enhanced by phosphorylation of the DNMT1 nuclear localization signal (NLS) by PKB/AKT kinase
brenda
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
endogenous DNMT1 copurifies with inhibitory ncRNAs. miRNAs bind directly to DNMT1 with high affinity, leading to inhibition of DNMT1 enzyme activity. Exogenous miR-155-5p in cells induces aberrant DNA methylation of the genome
physiological function
physiological function
-
DNMT1 is required to maintain global methylation after DNA replication has taken place
physiological function
-
the enzyme activity is involved in the epigenetic pathway of gene regulation
physiological function
-
while DNMT3a is mostly involved in de novo methylation, DNMT1 acts as a maintenance methyltransferase
physiological function
-
BPDE recruits DNMT3A to methylate the RAR-beta2 gene promoter and thus silence its gene expression, which in turn, may contribute to the malignant transformation of esophageal epithelial cells
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). DNMT1_HUMAN
1616
0
183165
Swiss-Prot
Mitochondrion (Reliability: 4)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
Dnmt1 has a small catalytid C-terminal domain and a large regulatory domain at the N-terminal, the two domains are linked by 12 Gly-Lys repeats, structure, overview
additional information
the conserved CXXC domain encompassing the amino terminus region of DNMT1 cooperates with the catalytic domain for DNA methyltransferase activity, and binds to unmethylated CpG
additional information
-
the conserved CXXC domain encompassing the amino terminus region of DNMT1 cooperates with the catalytic domain for DNA methyltransferase activity, and binds to unmethylated CpG
additional information
-
homology model for DNMT1 based on the template structures of the available comparable protein crystal structures, molecular dynamics, overview
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
-
IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
C667G
zinc-finger-domain point mutation in the CXXC motif abolishes unmethylated DNA binding activity
C667G/C670G
zinc-finger-domain point mutation in the CXXC motif abolishes unmethylated DNA binding activity
C670G
zinc-finger-domain point mutation in the CXXC motif abolishes unmethylated DNA binding activity
DELAT1-501
-
to accelerate the rate of DNMT1 with the hemimethylated substrate, the 501 amino acids at the N terminus are deleted. Truncated DNMT1 exhibits a 4fold increased kcat/Km as compared with the full-length enzyme and does not require allosteric activation by hemimethylated DNA
H286A/R287A
-
allosteric activation by methylated DNA is reduced, 6.5 fold decrease in the ratio turnover number/Km-value compared to wild-type enzyme
K284A/K285A
-
allosteric activation by methylated DNA is reduced, 1.7fold decrease in the ratio turnover number/Km-value compared to wild-type enzyme
additional information
additional information
construction of zinc-finger-domain point mutant and deletion mutant DNMT1 clones, CXXC deleted DNMT1, i.e. mutant DNMT1DELTACXXC and DNMT1 lacking the first 580 amino acids, i.e. DNMT1DELTA580. The latter prefers binding to unmethylated DNA instead of hemimethylated or fully methylated DNA like the wild-type enzyme. Deletion of CXXC domain in DNMT1 does not affect replication foci occupancy during DNA replication. A permanent cell line with DNMT1DELTACXXC displays partial loss of genomic methylation on rDNA loci, despite the presence of endogenous wild-type enzyme
additional information
-
construction of zinc-finger-domain point mutant and deletion mutant DNMT1 clones, CXXC deleted DNMT1, i.e. mutant DNMT1DELTACXXC and DNMT1 lacking the first 580 amino acids, i.e. DNMT1DELTA580. The latter prefers binding to unmethylated DNA instead of hemimethylated or fully methylated DNA like the wild-type enzyme. Deletion of CXXC domain in DNMT1 does not affect replication foci occupancy during DNA replication. A permanent cell line with DNMT1DELTACXXC displays partial loss of genomic methylation on rDNA loci, despite the presence of endogenous wild-type enzyme
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-80°C, little loss of activity after 4 weeks, significant loss of activity after 6 weeks
-
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Q-Sepharose column chromatography and Hitrap heparin column chromatography
DNMT3B copurifies with several components of the condensin complex and KIF4A
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNMT1, overexpression of HA-tagged CXXC deletion DNMT1 mutant, expression of wild-type and deletion mutant enzymes in COS-7 cells and Escherichia coli, CXXC deleted DNMT1, mutant DNMT1DELTACXXC, is localized on replication foci
DNMT1 and DNMT3a, expression analysis of the isozymes in salivary gland neoplasmata
-
expression of the enzyme by using a protein splicing fusion partner in a baculovirus expression vector
-
transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus, phenotype, overview
-
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
biotechnology
-
using a truncated and highly active form of human DNMT1 and a designed hemimethylated DNA substrate, a robust, efficient, and economical fluorescence assay is developped suitable for in vitro high-throughput screening of DNMT1
drug development
-
Dnmt inhibition is a promising strategy for the treatment of various developmental and proliferative diseases, particularly cancers
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Roy, P.H.; Weissbach, A.
DNA methylase from HeLa cell nuclei
Nucleic Acids Res.
2
1669-1684
1975
Homo sapiens
brenda
Pfeifer, G.P.; Grunwald, S.; Palitti, F.; Kaul, S.; Boehm, T.L.J.; Hirth, H.P.; Drahovsky, D.
Purification and characterization of mammalian DNA methyltransferases by use of monoclonal antibodies
J. Biol. Chem.
260
13787-13793
1985
Homo sapiens, Mus musculus
brenda
Pfeifer, G.P.; Grunwald, S.; Boehm, T.L.J.; Drahovsky, D.
Isolation and characterization of DNA cytosine 5-methyltransferase from human placenta
Biochim. Biophys. Acta
740
323-330
1983
Homo sapiens
brenda
McIntosh, L.P.; Zielinski, W.S.; Kalisch, B.W.; Pfeifer, G.P.; Sprinzl, M.; Drahovsky, D.; van de Sande, J.H.; Jovin, T.M.
Synthesis and characterization of poly[d(G-z5C)]. B-Z transition and inhibition of DNA methylase
Biochemistry
24
4806-4814
1985
Homo sapiens
brenda
Laayoun, A.; Smith, S.S.
Methylation of slipped duplexes, snapbacks and cruciforms by human DNA(cytosine-5)methyltransferase
Nucleic Acids Res.
23
1584-1589
1995
Homo sapiens
brenda
Pradhan, S.; Bacolla, A.; Wells, R.D.; Roberts, R.J.
Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of DE Novo and maintenance methylation
J. Biol. Chem.
274
33002-33010
1999
Homo sapiens
brenda
Bacolla, A.; Pradhan, S.; Larson, J.E.; Roberts, R.J.; Wells, R.D.
Recombinant human DNA (cytosine-5) methyltransferase: III. Allosteric control, reaction order, and influence of plasmid topology and triplet repeat length on methylation of the fragile X CGG*CCG sequence
J. Biol. Chem.
276
18605-18613
2001
Homo sapiens (P26358), Homo sapiens
brenda
Siedlecki, P.; Boy, R.G.; Comagic, S.; Schirrmacher, R.; Wiessler, M.; Zielenkiewicz, P.; Suhai, S.; Lyko, F.
Establishment and functional validation of a structural homology model for human DNA methyltransferase 1
Biochem. Biophys. Res. Commun.
306
558-563
2003
Homo sapiens (P26358), Homo sapiens
brenda
Robertson, A.K.; Geiman, T.M.; Sankpal, U.T.; Hager, G.L.; Robertson, K.D.
Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro
Biochem. Biophys. Res. Commun.
322
110-118
2004
Homo sapiens (P26358), Homo sapiens (Q9Y6K1)
brenda
Pradhan, S.; Esteve, P.O.
Allosteric activator domain of maintenance human DNA (cytosine-5) methyltransferase and its role in methylation spreading
Biochemistry
42
5321-5332
2003
Homo sapiens
brenda
Yokochi, T.; Robertson, K.D.
Dimethyl sulfoxide stimulates the catalytic activity of de novo DNA methyltransferase 3a (Dnmt3a) in vitro
Bioorg. Chem.
32
234-243
2004
Homo sapiens (Q9UBC3)
brenda
Fang, M.Z.; Wang, Y.; Ai, N.; Hou, Z.; Sun, Y.; Lu, H.; Welsh, W.; Yang, C.S.
Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
Cancer Res.
63
7563-7570
2003
Homo sapiens
brenda
Hermann, A.; Schmitt, S.; Jeltsch, A.
The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity
J. Biol. Chem.
278
31717-31721
2003
Homo sapiens
brenda
Casillas, M.A.; Lopatina, N.; Andrews, L.G.; Tollefsbol, T.O.
Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts
Mol. Cell. Biochem.
252
33-43
2003
Homo sapiens (P26358), Homo sapiens (Q9UBC3), Homo sapiens (Q9Y6K1), Homo sapiens
brenda
Geiman, T.M.; Sankpal, U.T.; Robertson, A.K.; Chen, Y.; Mazumdar, M.; Heale, J.T.; Schmiesing, J.A.; Kim, W.; Yokomori, K.; Zhao, Y.; Robertson, K.D.
Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery
Nucleic Acids Res.
32
2716-2729
2004
Homo sapiens (Q9UBC3)
brenda
Hodge, D.R.; Cho, E.; Copeland, T.D.; Guszczynski, T.; Yang, E.; Seth, A.K.; Farrar, W.L.
IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase
Cancer Genomics Proteomics
4
387-398
2008
Homo sapiens
brenda
Guo, Z.; Tsai, M.H.; Shiao, Y.H.; Chen, L.H.; Wei, M.L.; Lv, X.; Gius, D.; Little, J.B.; Mitchell, J.B.; Chuang, E.Y.
DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16(ink4A) down-regulation
J. Biomed. Sci.
15
163-168
2008
Homo sapiens
brenda
Pradhan, M.; Esteve, P.O.; Chin, H.G.; Samaranayke, M.; Kim, G.D.; Pradhan, S.
CXXC domain of human DNMT1 is essential for enzymatic activity
Biochemistry
47
10000-10009
2008
Homo sapiens (P26358), Homo sapiens
brenda
Wang, H.; Wang, Y.
6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo
Biochemistry
48
2290-2299
2009
Haemophilus parainfluenzae, Homo sapiens
brenda
Saavedra, O.M.; Isakovic, L.; Llewellyn, D.B.; Zhan, L.; Bernstein, N.; Claridge, S.; Raeppel, F.; Vaisburg, A.; Elowe, N.; Petschner, A.J.; Rahil, J.; Beaulieu, N.; MacLeod, A.R.; Delorme, D.; Besterman, J.M.; Wahhab, A.
SAR around (L)-S-adenosyl-L-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes
Bioorg. Med. Chem. Lett.
19
2747-2751
2009
Homo sapiens (P26358), Homo sapiens (Q9UBC3), Homo sapiens
brenda
Kuck, D.; Singh, N.; Lyko, F.; Medina-Franco, J.L.
Novel and selective DNA methyltransferase inhibitors: docking-based virtual screening and experimental evaluation
Bioorg. Med. Chem.
18
822-829
2009
Homo sapiens
brenda
Ooi, S.K.; Bestor, T.H.
The colorful history of active DNA demethylation
Cell
133
1145-1148
2008
Homo sapiens, Mus musculus
brenda
Singh, N.; Duenas-Gonzalez, A.; Lyko, F.; Medina-Franco, J.L.
Molecular modeling and molecular dynamics studies of hydralazine with human DNA methyltransferase 1
ChemMedChem
4
792-799
2009
Homo sapiens
brenda
Svedruzic, Z.M.
Mammalian cytosine DNA methyltransferase Dnmt1: enzymatic mechanism, novel mechanism-based inhibitors, and RNA-directed DNA methylation
Curr. Med. Chem.
15
92-106
2008
Homo sapiens (P26358)
brenda
Balada, E.; Ordi-Ros, J.; Serrano-Acedo, S.; Martinez-Lostao, L.; Rosa-Leyva, M.; Vilardell-Tarres, M.
Transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus
Immunology
124
339-347
2008
Homo sapiens
brenda
Cavalieri Gomes, C.; da Silveira e Oliveira, C.; Santos Pimenta, L.G.; De Marco, L.; Santiago Gomez, R.
Immunolocalization of DNMT1 and DNMT3a in salivary gland neoplasms
Pathobiology
76
136-140
2009
Homo sapiens
brenda
Ye, Y.; Stivers, J.T.
Fluorescence-based high-throughput assay for human DNA (cytosine-5)-methyltransferase 1
Anal. Biochem.
401
168-172
2010
Homo sapiens
brenda
Ye, F.; Xu, X.C.
Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-beta2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A
Mol. Cancer
9
93
2010
Homo sapiens
brenda
Zhang, G.; Esteve, P.; Chin, H.; Terragni, J.; Dai, N.; Correa, I.J.; Pradhan, S.
Small RNA-mediated DNA (cytosine-5) methyltransferase 1 inhibition leads to aberrant DNA methylation
Nucleic Acids Res.
43
6112-6124
2015
Homo sapiens (P26358)
brenda
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