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Information on EC 2.1.1.297 - peptide chain release factor N5-glutamine methyltransferase and Organism(s) Mus musculus and UniProt Accession Q6SKR2

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IUBMB Comments
Modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity.
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This record set is specific for:
Mus musculus
UNIPROT: Q6SKR2
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
[peptide chain release factor 1 or 2]-L-glutamine
=
+
[peptide chain release factor 1 or 2]-N5-methyl-L-glutamine
Synonyms
hemk2, hemk1, n5-glutamine methyltransferase, prmc/hemk, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
HemK methyltransferase family member 2, isoform CRA_c
-
Hemk2
Q6PRU9
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:[peptide chain release factor 1 or 2]-L-glutamine (N5-glutamine)-methyltransferase
Modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
isoform HemK1
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Q6PRU9, Q6SKR2
abundant mRNA expression
Manually annotated by BRENDA team
Q6PRU9, Q6SKR2
abundant mRNA expression in embryonic stem cells, weak expression in differentiated embryonic stem cells, protein is most abundant in undifferentiated embryonic stem cells
Manually annotated by BRENDA team
Q6PRU9, Q6SKR2
weak mRNA expression
Manually annotated by BRENDA team
Q6PRU9, Q6SKR2
abundant mRNA expression
Manually annotated by BRENDA team
Q6PRU9, Q6SKR2
abundant mRNA expression
Manually annotated by BRENDA team
Q6PRU9, Q6SKR2
abundant mRNA expression in embryonic stem cells, weak expression in differentiated embryonic stem cells, proein is most abundant in undifferentiated embryonic stem cells
Manually annotated by BRENDA team
Q6PRU9, Q6SKR2
weak mRNA expression
Manually annotated by BRENDA team
Q6PRU9, Q6SKR2
abundant mRNA expression
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Q6PRU9, Q6SKR2
isoform HemK1 is detected mainly in the nucleus of COS7 cell lines after 24 h post-transfection
Manually annotated by BRENDA team
Q6PRU9, Q6SKR2
isoform HemK1 is detected mainly in the nucleus of COS7 cell lines after 24 h post-transfection
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
Q6PRU9, Q6SKR2
the cell proliferation decreases after RNAi with Hemk1
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
N6MT1_MOUSE
214
0
22984
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nie, D.S.; Liu, Y.B.; Lu, G.X.
Cloning and primarily function study of two novel putative N5-glutamine methyltransferase (Hemk) splice variants from mouse stem cells
Mol. Biol. Rep.
36
2221-2228
2009
Mus musculus (Q6PRU9), Mus musculus (Q6SKR2)
Manually annotated by BRENDA team