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Disease on EC 2.1.1.28 - phenylethanolamine N-methyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
Phenylethanolamine N-methyltransferase gene polymorphisms and adverse outcomes in acute kidney injury.
Alzheimer Disease
Degenerative changes in epinephrine tonic vasomotor neurons in Alzheimer's disease.
Phenylethanolamine N-methyltransferase (PNMT) gene and early-onset Alzheimer disease.
Phenylethanolamine N-methyltransferase activity is decreased in Alzheimer's disease brains.
Anemia, Sickle Cell
Phenylethanolamine N-methyltransferase gene polymorphisms associate with crisis pain in sickle cell disease patients.
Asthma
?2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine model.
Epistasis between phenylethanolamine N-methyltransferase and ?2-adrenergic receptor influences extracellular epinephrine level and associates with the susceptibility to allergic asthma.
Bradycardia
The effects of PNMT inhibitors upon cardiovascular changes induced by hemorrhage in the rat.
Breast Neoplasms
Gene expression profiling detects gene amplification and differentiates tumor types in breast cancer.
Cardiomyopathies
Increased gene expression of catecholamine-synthesizing enzymes in adrenal glands contributes to high circulating catecholamines in pigs with tachycardia-induced cardiomyopathy.
Cholera
Adrenergic innervation of forebrain neurons that project to the paraventricular thalamic nucleus in the rat.
Quantitative analysis of spinally projecting adrenaline-synthesising neurons of C1, C2 and C3 groups in rat medulla oblongata.
Cushing Syndrome
Adrenal medulla secretion in Cushing's syndrome.
Essential Hypertension
Phenylethanolamine N-Methyltransferase Gene Promoter Haplotypes and Risk of Essential Hypertension.
Genetic Diseases, Inborn
Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson's disease (PD): historical overview and future prospects.
Herpes Zoster
Origin of cocaine- and amphetamine-regulated transcript (CART)-immunoreactive innervation of the hypothalamic paraventricular nucleus.
Hyperalgesia
The Adrenal Medulla Modulates Mechanical Allodynia in a Rat Model of Neuropathic Pain.
Hypertension
Catecholamine-stimulated cyclic AMP formation in phenylethanolamine N-methyltransferase containing brain stem nuclei of normal rats and of rats with spontaneous genetic hypertension.
Evidence for a sodium-induced activation of central neurogenic mechanisms in one-kidney, one-clip renal hypertensive rats.
Glucocorticoid hypertension and nonadrenal phenylethanolamine N-methyltransferase.
Investigation of the phenylethanolamine N-methyltransferase gene as a candidate gene for hypertension.
Normotensive incidentally discovered pheochromocytomas display specific biochemical, cellular and molecular characteristics.
Phenylethanolamine N-methyltransferase gene expression in PC12 cells exposed to intermittent hypoxia.
Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine N-Methyltransferase Possessing Low Nanomolar Affinity at Both Substrate Binding Domains1.
Hypertension, Renovascular
Catecholamine synthesizing enzymes in brain stem and hypothalamus during the development of renovascular hypertension.
Hypoglycemia
Antecedent hypoglycemia, catecholamine depletion, and subsequent sympathetic neural responses.
Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats.
Kidney Diseases
Adrenal medulla secretion in Cushing's syndrome.
Lichen Planus
The specificity and cellular origin of phenylethanolamine N-methyltransferase (PNMT)-like immunoreactivity in psoriatic skin.
Lordosis
Inhibition of guinea pig lordosis behavior by the phenylethanolamine N-methyltransferase (PNMT) inhibitor SKF-64139: mediation by alpha noradrenergic receptors.
Medulloblastoma
Regulation of PNMT gene promoter constructs transfected into the TE 671 human medulloblastoma cell line.
Multiple Endocrine Neoplasia
Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 display distinct biochemical and clinical phenotypes.
Transcriptional regulation of phenylethanolamine N-methyltransferase in pheochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2.
Multiple Endocrine Neoplasia Type 2a
Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 display distinct biochemical and clinical phenotypes.
Transcriptional regulation of phenylethanolamine N-methyltransferase in pheochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2.
Multiple Sclerosis
Association between the phenylethanolamine N-methyltransferase gene and multiple sclerosis.
Neoplasms
A developmental model of neuroblastoma: differentiating stroma-poor tumors' progress along an extra-adrenal chromaffin lineage.
Adrenal and retroperitoneal mixed neuroendocrine-neural tumors.
Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.
Hypoxia-inducible Factor 2?: A Key Player in Tumorigenesis and Metastasis of Pheochromocytoma and Paraganglioma?
Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 display distinct biochemical and clinical phenotypes.
Studies of a transplantable rat pheochromocytoma: biochemical characterization and catecholamine secretion.
Transcriptional regulation of phenylethanolamine N-methyltransferase in pheochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2.
Transgenic mice express the human phenylethanolamine N-methyltransferase gene in adrenal medulla and retina.
Neuroblastoma
Adrenal and retroperitoneal mixed neuroendocrine-neural tumors.
Pancreatic Neoplasms
Expression profiles of pancreatic cancer cell lines infected with antisense K-ras-expressing adenoviral vector.
Papilloma
Characterization of recombinant bovine phenylethanolamine N-methyltransferase expressed in a mouse C127 cell line.
Parkinson Disease
Loss of C1 and C3 epinephrine-synthesizing neurons in the medulla oblongata in Parkinson's disease.
Phenylethanolamine N-methyltransferase has beta-carboline 2N-methyltransferase activity: hypothetical relevance to Parkinson's disease.
Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson's disease (PD): historical overview and future prospects.
Parkinsonian Disorders
Phenylethanolamine N-methyltransferase and other enzymes of catecholamine metabolism in human brain.
Pheochromocytoma
Adrenal and retroperitoneal mixed neuroendocrine-neural tumors.
Animal models of pheochromocytoma.
Deficiency of Phenylethanolamine N-Methyltransferase in Norepinephrine-Producing Pheochromocytoma.
Immunohistochemical localization of catecholamine-synthesizing enzymes in human pheochromocytomas.
Normotensive incidentally discovered pheochromocytomas display specific biochemical, cellular and molecular characteristics.
Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 display distinct biochemical and clinical phenotypes.
Transcriptional regulation of phenylethanolamine N-methyltransferase in pheochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2.
Psoriasis
Phenylethanolamine N-methyltransferase-like immunoreactivity in psoriasis. An immunohistochemical study on catecholamine synthesizing enzymes and neuropeptides of the skin.
Reperfusion Injury
Activation of Different Neuronal Phenotypes in the Rat Brain Induced by Liver Ischemia-Reperfusion Injury: Dual Fos/Neuropeptide Immunohistochemistry.
von Hippel-Lindau Disease
Transcriptional regulation of phenylethanolamine N-methyltransferase in pheochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2.