Information on EC 2.1.1.25 - phenol O-methyltransferase

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The expected taxonomic range for this enzyme is: Euarchontoglires

EC NUMBER
COMMENTARY
2.1.1.25
-
RECOMMENDED NAME
GeneOntology No.
phenol O-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
methyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:phenol O-methyltransferase
Acts on a wide variety of simple alkyl-, methoxy- and halo-phenols.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
methyltransferase, phenol
-
-
-
-
PMT
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
37256-94-3
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + acetaminophen
S-adenosyl-L-homocysteine + N-(4-methoxyphenyl)-acetamide
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + m-bromophenol
S-adenosyl-L-homocysteine + m-bromoanisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + m-chlorophenol
S-adenosyl-L-homocysteine + m-chloroanisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + m-methoxyphenol
S-adenosyl-L-homocysteine + 1,3-dimethoxybenzene
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + m-nitrophenol
S-adenosyl-L-homocysteine + m-nitroanisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + o-chlorophenol
S-adenosyl-L-homocysteine + o-chloroanisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + o-methylphenol
S-adenosyl-L-homocysteine + o-methylanisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + o-methyoxyphenol
S-adenosyl-L-homocysteine + veratrole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + p-chlorophenol
S-adenosyl-L-homocysteine + p-chloroanisole
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + p-ethylphenol
S-adenosyl-L-homocysteine + p-ethylanisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + p-hydroxyacetanilide
S-adenosyl-L-homocysteine + p-methoxyacetanilide
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + p-methoxyphenol
S-adenosyl-L-homocysteine + 1,4-dimethoxybenzene
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + p-methylphenol
S-adenosyl-L-homocysteine + p-methylanisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + phenol
S-adenosyl-L-homocysteine + anisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + phenol
S-adenosyl-L-homocysteine + anisole
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + phenol
S-adenosyl-L-homocysteine + anisole
show the reaction diagram
-
-
-
?
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
Mg2+
-
10 mM, 61% inhibition
NEM
-
0.1 mM, 90% inhibition
PCMB
-
0.01 mM, 85% inhibition
SKF 525
-
0.5 mM, 56% inhibition
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
21.2
-
acetaminophen
-
-
2
-
Phenol
-
-
0.0048
-
S-adenosyl-L-methionine
-
-
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7.6
8.3
-
-
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
-
activity is lower in membranes from uremic patients on maintenance hemodialysis than in blood from randomly selected subjects
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
from erythrocyte
Manually annotated by BRENDA team