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Information on EC 2.1.1.206 - tRNA (cytidine56-2'-O)-methyltransferase and Organism(s) Pyrococcus horikoshii and UniProt Accession O58214

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.206 tRNA (cytidine56-2'-O)-methyltransferase
IUBMB Comments
The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts.
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This record set is specific for:
Pyrococcus horikoshii
UNIPROT: O58214
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Word Map
The taxonomic range for the selected organisms is: Pyrococcus horikoshii
The expected taxonomic range for this enzyme is: Archaea, Bacteria
Reaction Schemes
Synonyms
atrm56, transfer rna methyltransferase, trm56, ta0931, pab1040, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tRNA ribose 2'-O-methyltransferase aTrm56
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:tRNA (cytidine56-2'-O)-methyltransferase
The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + cytidine56 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA
show the reaction diagram
Pyrococcus horikoshii tRNAVal. aTrm56 prefers the L-shaped tRNA to the lambda form as its substrate
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-
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging drop vapor diffusion method, crystal structure of Pyrococcus horikoshii aTrm56 complexed with S-adenosyl-L-methionine at 2.48 A resolution
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kuratani, M.; Bessho, Y.; Nishimoto, M.; Grosjean, H.; Yokoyama, S.
Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA
J. Mol. Biol.
375
1064-1075
2008
Pyrococcus horikoshii (O58214), Pyrococcus horikoshii
Manually annotated by BRENDA team