Information on EC 2.1.1.19 - trimethylsulfonium-tetrahydrofolate N-methyltransferase

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The expected taxonomic range for this enzyme is: Pseudomonas sp.

EC NUMBER
COMMENTARY
2.1.1.19
-
RECOMMENDED NAME
GeneOntology No.
trimethylsulfonium-tetrahydrofolate N-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
trimethylsulfonium + tetrahydrofolate = dimethylsulfide + 5-methyltetrahydrofolate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
methyl group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
folate transformations I
-
One carbon pool by folate
-
SYSTEMATIC NAME
IUBMB Comments
trimethylsulfonium:tetrahydrofolate N-methyltransferase
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
trimethylsulfonium-tetrahydrofolate methyltransferase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
37256-92-1
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
atypical pseudomonad with two lateral, subpolar flagellae
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
trimethylsulfonium + tetrahydrofolate
dimethylsulfide + 5-methyltetrahydrofolate
show the reaction diagram
-
-
-
?
additional information
?
-
-
S-adenosylmethionine and dimethyl-beta-propiothetin are not accepted as methyl donors
-
-
-
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
tetrahydrofolate
-
-
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
2-mercaptoethanol
-
inhibitory in excess
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
2-mercaptoethanol
-
reducing agent required for activity
ascorbate
-
can replace 2-mercaptoethanol, best reducing agent for reaction assay
homocysteine
-
can replace 2-mercaptoethanol
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
1
-
tetrahydrofolate
-
-
5.8
-
Trimethylsulfonium
-
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
0.007
-
-
purified enzyme
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7.8
-
-
broad optimum
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
100000
-
-
sucrose density gradient centrifugation
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
-20°C, 80% activity retained after 4 months
-
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE