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Information on EC 2.1.1.182 - 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase and Organism(s) Aquifex aeolicus and UniProt Accession O67680

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EC Tree
IUBMB Comments
KsgA introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine1518 and adenine1519 in 16S rRNA. Strains lacking the methylase are resistant to kasugamycin .
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Aquifex aeolicus
UNIPROT: O67680
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The taxonomic range for the selected organisms is: Aquifex aeolicus
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Reaction Schemes
4
+
adenine1518/adenine1519 in 16S rRNA
=
4
+
N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
Synonyms
ksga methyltransferase, s-adenosylmethionine-6-n',n'-adenosyl (rrna) dimethyltransferase, 16s rrna adenine dimethyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase
KsgA introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine1518 and adenine1519 in 16S rRNA. Strains lacking the methylase are resistant to kasugamycin [1].
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
structures of KsgA, in its ligand-free form, in complex with RNA and in complex with both RNA and S-adenosylhomocysteine
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tu, C.; Tropea, J.E.; Austin, B.P.; Court, D.L.; Waugh, D.S.; Ji, X.
Structural basis for binding of RNA and cofactor by a KsgA methyltransferase
Structure
17
374-385
2009
Aquifex aeolicus (O67680), Aquifex aeolicus
Manually annotated by BRENDA team