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Reference on EC 2.1.1.17 - phosphatidylethanolamine N-methyltransferase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ridgway, N.D.; Vance, D.E.
Phosphatidylethanolamine N-methyltransferase from rat liver
Methods Enzymol.
209
366-374
1992
Rattus norvegicus
Manually annotated by BRENDA team
Vance, D.E.; Schneider, W.J.
Conversion of phosphatidylethanolamine to phosphatidylcholine
Methods Enzymol.
71
581-588
1981
Rattus norvegicus
Manually annotated by BRENDA team
Gaynor, P.M.; Carman, G.M.
Phosphatidylethanolamine methyltransferase and phospholipid methyltransferase activities from Saccharomyces cerevisiae. Enzymological and kinetic properties
Biochim. Biophys. Acta
1045
156-163
1990
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Pajares, M.A.; Villalba, M.; Mato, J.M.
Purification of phospholipid methyltransferase from rat liver microsomal fraction
Biochem. J.
237
699-705
1986
Rattus norvegicus
Manually annotated by BRENDA team
McBride, K.; Furness, L.M.; Gibbons, W.A.
Lipid methyltransferase: purification and structure
Biochem. Soc. Trans.
15
924-925
1987
Rattus norvegicus
-
Manually annotated by BRENDA team
Fonteh, A.N.; Gibbons, W.A.
Solubilization and purification of lipid methyltransferase
Biochem. Soc. Trans.
18
266-267
1990
Rattus norvegicus
Manually annotated by BRENDA team
Varela, I.; Merida, I.; Pajares, M.; Villalba, M.; Mato, J.M.
Activation of partially purified rat liver lipid methyltransferase by phosphorylation
Biochem. Biophys. Res. Commun.
122
1065-1070
1984
Rattus norvegicus
Manually annotated by BRENDA team
Ridgway, N.D.; Vance, D.E.
Kinetic mechanism of phosphatidylethanolamine N-methyltransferase
J. Biol. Chem.
263
16864-16871
1988
Rattus norvegicus
Manually annotated by BRENDA team
Prasad, C.; Edwards, R.M.
Synthesis of phosphatidylcholine from phosphatidylethanolamine by at least two methyltransferases in rat pituitary extracts
J. Biol. Chem.
256
13000-13003
1981
Rattus norvegicus
-
Manually annotated by BRENDA team
Dudeja, P.K.; Foster, E.S.; Brasitus, T.A.
Synthesis of phosphatidylcholine by two distinct methyltransferases in rat colonic brush-border membranes: evidence for extrinsic and intrinsic membrane activities
Biochim. Biophys. Acta
875
493-500
1986
Rattus norvegicus
Manually annotated by BRENDA team
Ridgway, N.D.; Vance, D.E.
Purification of phosphatidylethanolamine N-methyltransferase from rat liver
J. Biol. Chem.
262
17231-17239
1987
Rattus norvegicus
Manually annotated by BRENDA team
Tahara, Y.; Ogawa, Y.; Sakakibara, T.; Yamada, Y.
Purification and characterization of phosphatidylethanolamine N-methyltransferase from Zymomonas mobilis
Agric. Biol. Chem.
51
1425-1430
1987
Zymomonas mobilis
-
Manually annotated by BRENDA team
Tahara, Y.; Ogawa, Y.; Sakakibara, T.; Yamada, Y.
Phosphatidylethanolamine N-methyltransferase from Zymomonas mobilis: purification and characterization
Agric. Biol. Chem.
50
257-259
1986
Zymomonas mobilis
-
Manually annotated by BRENDA team
Makishima, F.; Toyoshima, S.; Osawa, T.
Partial purification and characterization of phospholipid N-methyltransferases from murine thymocyte microsomes
Arch. Biochem. Biophys.
238
315-324
1985
Mus musculus
Manually annotated by BRENDA team
Morgan, T.E.
Isolation and characterization of lipid N-methyltransferase from dog lung
Biochim. Biophys. Acta
178
21-34
1969
Canis sp.
Manually annotated by BRENDA team
Vance, D.E.; Walkey, C.J.; Cui, Z.
Phosphatidylethanolamine N-methyltransferase from liver
Biochim. Biophys. Acta
1348
142-150
1997
Rattus norvegicus
Manually annotated by BRENDA team
Cui, Z.; Shen, Y.J.; Vance, D.E.
Inverse correlation between expression of phosphatidylethanolamine N-methyltransferase-2 and growth rate of perinatal rat livers
Biochim. Biophys. Acta
1346
10-16
1997
Rattus norvegicus
Manually annotated by BRENDA team
Nishimaki-Mogami, T.; Suzuki, K.; Takahashi, A.
The role of phosphatidylethanolamine methylation in the secretion of very low density lipoproteins by cultured rat hepatocytes: rapid inhibition of phosphatidylethanolamine methylation by bezafibrate increases the density of apolipoprotein B48-containing lipoproteins
Biochim. Biophys. Acta
1304
21-31
1996
Rattus norvegicus
Manually annotated by BRENDA team
Shields, D.J.; Lehner, R.; Agellon, L.B.; Vance, D.E.
Membrane topography of human phosphatidylethanolamine N-methyltransferase
J. Biol. Chem.
278
2956-2962
2003
Homo sapiens
Manually annotated by BRENDA team
Tessitore, L.; Dianzani, I.; Cui, Z.; Vance, D.E.
Diminished expression of phosphatidylethanolamine N-methyltransferase 2 during hepatocarcinogenesis
Biochem. J.
337
23-27
1999
Rattus norvegicus
-
Manually annotated by BRENDA team
Tessitore, L.; Cui, Z.; Vance, D.E.
Transient inactivation of phosphatidylethanolamine N-methyltransferase-2 and activation of cytidine triphosphate:phosphocholine cytidylyltransferase during non-neoplastic liver growth
Biochem. J.
322
151-154
1997
Rattus norvegicus
-
Manually annotated by BRENDA team
Waite, K.A.; Vance, D.E.
Why expression of phosphatidylethanolamine N-methyltransferase does not rescue Chinese hamster ovary cells that have an impaired CDP-choline pathway
J. Biol. Chem.
275
21197-21202
2000
Cricetulus griseus
Manually annotated by BRENDA team
Cui, Z.; Vance, D.E.
Expression of phosphatidylethanolamine N-methyltransferase-2 is markedly enhanced in long term choline-deficient rats
J. Biol. Chem.
271
2839-2843
1996
Rattus norvegicus
Manually annotated by BRENDA team
Lee, M.W.; Bakovic, M.; Vance, D.E.
Overexpression of phosphatidylethanolamine N-methyltransferase 2 in CHO-K1 cells does not attenuate the activity of the CDP-choline pathway for phosphatidylcholine biosynthesis
Biochem. J.
320
905-910
1996
Cricetulus griseus
-
Manually annotated by BRENDA team
Lee, E.S.Y.; Charlton, C.G.
1-Methyl-4-phenyl-pyridinium increases S-adenosyl-L-methionine dependent phospholipid methylation
Pharmacol. Biochem. Behav.
70
105-114
2001
Rattus norvegicus
Manually annotated by BRENDA team
Tessitore, L.; Sesca, E.; Bosco, M.; Vance, D.E.
Expression of phosphatidylethanolamine N-methyltransferase in Yoshida ascites hepatoma cells and the livers of host rats
Carcinogenesis
20
561-567
1999
Rattus norvegicus
Manually annotated by BRENDA team
Guan, Z.Z.; Wang, Y.N.; Xiao, K.Q.; Hu, P.S.; Liu, J.L.
Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease
Neurochem. Int.
34
41-47
1999
Homo sapiens
Manually annotated by BRENDA team
Kim, Y.J.; Park, H.S.; Choi, M.U.
Detection of cytosolic phosphatidylethanolamine N-methyltransferase in rat brain
J. Biochem. Mol. Biol.
31
170-176
1998
Rattus norvegicus
-
Manually annotated by BRENDA team
Vance, D.E.
Phosphatidylethanolamine N-methyltransferase: Unexpected findings from curiosity-driven research
Eur. J. Med. Res.
1
182-188
1996
Rattus norvegicus
Manually annotated by BRENDA team
Roque, M.E.; Giusto, N.M.
Phosphatidylethanolamine N-methyltransferase activity in isolated rod outer segments from bovine retina
Exp. Eye Res.
60
631-643
1995
Bos taurus
Manually annotated by BRENDA team
Roque, M.E.; Salvador, G.A.; Giusto, N.M.
Light activation of phosphatidylethanolamine N-methyltransferase in rod outer segments and its modulation by association states of transducin
Exp. Eye Res.
69
555-562
1999
Bos taurus
Manually annotated by BRENDA team
Tessitore, L.; Sesca, E.; Vance, D.E.
Inactivation of phosphatidylethanolamine N-methyltransferase-2 in aflatoxin-induced liver cancer and partial reversion of the neoplastic phenotype by PEMT transfection of hepatoma cells
Int. J. Cancer
86
362-367
2000
Rattus norvegicus
Manually annotated by BRENDA team
Shields, D.J.; Lingrell, S.; Agellon, L.B.; Brosnan, J.T.; Vance, D.E.
Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase
J. Biol. Chem.
280
27339-27344
2005
Mus musculus
Manually annotated by BRENDA team
Watkins, S.M.; Zhu, X.; Zeisel, S.H.
Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice
J. Nutr.
133
3386-3391
2003
Mus musculus
Manually annotated by BRENDA team
Gotoh, T.; Ando, N.; Kikuchi, K.
A novel method for in vitro radiolabeling and testing enveloped viruses by phosphatidylethanolamine N-methyltransferase and host cell-specific binding
Biotechnol. Bioeng.
94
1017-1024
2006
Sus scrofa
Manually annotated by BRENDA team
Mueller, H.; Grande, T.; Ahlstr?m, O.; Skrede, A.
A diet rich in phosphatidylethanolamine increases plasma homocysteine in mink: a comparison with a soybean oil diet
Br. J. Nutr.
94
684-690
2005
Neogale vison
Manually annotated by BRENDA team
Zhu, X.; Zeisel, S.H.
Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice
Brain Res. Mol. Brain Res.
134
239-255
2005
Mus musculus
Manually annotated by BRENDA team
Igolnikov, A.C.; Green, R.M.
Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet
J. Hepatol.
44
586-592
2006
Mus musculus
Manually annotated by BRENDA team
Kharbanda, K.K.; Mailliard, M.E.; Baldwin, C.R.; Beckenhauer, H.C.; Sorrell, M.F.; Tuma, D.J.
Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway
J. Hepatol.
46
314-321
2007
Rattus norvegicus, Rattus norvegicus (Q08388)
Manually annotated by BRENDA team
Hartz, C.S.; Nieman, K.M.; Jacobs, R.L.; Vance, D.E.; Schalinske, K.L.
Hepatic phosphatidylethanolamine N-methyltransferase expression is increased in diabetic rats
J. Nutr.
136
3005-3009
2006
Rattus norvegicus
Manually annotated by BRENDA team
Li, Z.; Agellon, L.B.; Vance, D.E.
A role for high density lipoproteins in hepatic phosphatidylcholine homeostasis
Biochim. Biophys. Acta
1771
893-900
2007
Mus musculus
Manually annotated by BRENDA team
Resseguie, M.; Song, J.; Niculescu, M.D.; da Costa, K.; Randall, T.A.; Zeisel, S.H.
Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes
FASEB J.
21
2622-2632
2007
Mus musculus (Q61907), Mus musculus, Homo sapiens (Q9UBM1), Homo sapiens
Manually annotated by BRENDA team
Xu, X.; Gammon, M.D.; Zeisel, S.H.; Lee, Y.L.; Wetmur, J.G.; Teitelbaum, S.L.; Bradshaw, P.T.; Neugut, A.I.; Santella, R.M.; Chen, J.
Choline metabolism and risk of breast cancer in a population-based study
FASEB J.
22
2045-2052
2008
Homo sapiens (Q9UBM1)
Manually annotated by BRENDA team
Vance, D.E.; Li, Z.; Jacobs, R.L.
Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology
J. Biol. Chem.
282
33237-33241
2007
Mus musculus
Manually annotated by BRENDA team
Zhao, Y.; Su, B.; Jacobs, R.L.; Kennedy, B.; Francis, G.A.; Waddington, E.; Brosnan, J.T.; Vance, J.E.; Vance, D.E.
Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice
Arterioscler. Thromb. Vasc. Biol.
29
1349-1355
2009
Mus musculus
Manually annotated by BRENDA team
Jun, D.W.; Han, J.H.; Jang, E.C.; Kim, S.H.; Kim, S.H.; Jo, Y.J.; Park, Y.S.; Chae, J.D.
Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans
Eur. J. Gastroenterol. Hepatol.
21
667-672
2009
Homo sapiens
Manually annotated by BRENDA team
Ivanov, A.; Nash-Barboza, S.; Hinkis, S.; Caudill, M.A.
Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted
J. Am. Diet. Assoc.
109
313-318
2009
Homo sapiens
Manually annotated by BRENDA team
Hacker, S.; Sohlenkamp, C.; Aktas, M.; Geiger, O.; Narberhaus, F.
Multiple phospholipid N-methyltransferases with distinct substrate specificities are encoded in Bradyrhizobium japonicum
J. Bacteriol.
190
571-580
2008
Bradyrhizobium japonicum, Bradyrhizobium japonicum USDA 110
Manually annotated by BRENDA team
Caudill, M.A.; Dellschaft, N.; Solis, C.; Hinkis, S.; Ivanov, A.A.; Nash-Barboza, S.; Randall, K.E.; Jackson, B.; Solomita, G.N.; Vermeylen, F.
Choline intake, plasma riboflavin, and the phosphatidylethanolamine N-methyltransferase G5465A genotype predict plasma homocysteine in folate-deplete Mexican-American men with the methylenetetrahydrofolate reductase 677TT genotype
J. Nutr.
139
727-733
2009
Homo sapiens
Manually annotated by BRENDA team
Li, Z.; Agellon, L.B.; Vance, D.E.
The role of phosphatidylethanolamine methyltransferase in a mouse model of intrahepatic cholestasis
Biochim. Biophys. Acta
1811
278-283
2011
Mus musculus
Manually annotated by BRENDA team
Morrill, G.; Kostellow, A.; Askari, A.
Progesterone modulation of transmembrane helix-helix interactions between the -subunit of Na/K-ATPase and phospholipid N-methyltransferase in the oocyte plasma membrane
BMC Struct. Biol.
10
12
2010
Lithobates pipiens
Manually annotated by BRENDA team
Morita, S.Y.; Ikeda, N.; Horikami, M.; Soda, K.; Ishihara, K.; Teraoka, R.; Terada, T.; Kitagawa, S.
Effects of phosphatidylethanolamine N-methyltransferase on phospholipid composition, microvillus formation and bile salt resistance in LLC-PK1 cells
FEBS J.
278
4768-4781
2011
Homo sapiens (Q9UBM1)
Manually annotated by BRENDA team
Aktas, M.; Gleichenhagen, J.; Stoll, R.; Narberhaus, F.
S-adenosylmethionine-binding properties of a bacterial phospholipid N-methyltransferase
J. Bacteriol.
193
3473-3481
2011
Agrobacterium tumefaciens
Manually annotated by BRENDA team
Cole, L.K.; Vance, D.E.
A role for Sp1 in transcriptional regulation of phosphatidylethanolamine N-methyltransferase in liver and 3T3-L1 adipocytes
J. Biol. Chem.
285
11880-11891
2010
Mus musculus
Manually annotated by BRENDA team
Pynn, C.J.; Henderson, N.G.; Clark, H.; Koster, G.; Bernhard, W.; Postle, A.D.
Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo
J. Lipid Res.
52
399-407
2011
Homo sapiens
Manually annotated by BRENDA team
Athamena, A.; Trajkovic-Bodennec, S.; Brichon, G.; Zwingelstein, G.; Bodennec, J.
Synthesis of phosphatidylcholine through phosphatidylethanolamine N-methylation in tissues of the mussel Mytilus galloprovincialis
Lipids
46
1141-1154
2011
Mytilus galloprovincialis
Manually annotated by BRENDA team
Kobayashi, S.; Mizuike, A.; Horiuchi, H.; Fukuda, R.; Ohta, A.
Mitochondrially-targeted bacterial phosphatidylethanolamine methyltransferase sustained phosphatidylcholine synthesis of a Saccharomyces cerevisiae DELTApem1 DELTApem2 double mutant without exogenous choline supply
Biochim. Biophys. Acta
1841
1264-1271
2014
Acetobacter aceti, Acetobacter aceti NBRC 3283
Manually annotated by BRENDA team
Valtolina, C.; Vaandrager, A.B.; Favier, R.P.; Robben, J.H.; Tuohetahuntila, M.; Kummeling, A.; Jeusette, I.; Rothuizen, J.
No up-regulation of the phosphatidylethanolamine N-methyltransferase pathway and choline production by sex hormones in cats
BMC Vet. Res.
11
280
2015
Felis catus (M3W4J4), Felis catus
Manually annotated by BRENDA team
Tajuddin, S.M.; Amaral, A.F.; Fernandez, A.F.; Chanock, S.; Silverman, D.T.; Tardon, A.; Carrato, A.; Garcia-Closas, M.; Jackson, B.P.; Torano, E.G.; Marquez, M.; Urdinguio, R.G.; Garcia-Closas, R.; Rothman, N.; Kogevinas, M.; Real, F.X.; Fraga, M.F.; Malats, N.; Malats, N.
LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk
Br. J. Cancer
110
2123-2130
2014
Homo sapiens
Manually annotated by BRENDA team
Danne, L.; Aktas, M.; Gleichenhagen, J.; Grund, N.; Wagner, D.; Schwalbe, H.; Hoffknecht, B.; Metzler-Nolte, N.; Narberhaus, F.
Membrane-binding mechanism of a bacterial phospholipid N-methyltransferase
Mol. Microbiol.
95
313-331
2015
Agrobacterium tumefaciens
Manually annotated by BRENDA team
Gao, X.; van der Veen, J.N.; Vance, J.E.; Thiesen, A.; Vance, D.E.; Jacobs, R.L.
Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress
Biochim. Biophys. Acta
1852
2689-2699
2015
Mus musculus (Q61907), Mus musculus
Manually annotated by BRENDA team
Presa, N.; Clugston, R.D.; Lingrell, S.; Kelly, S.E.; Merrill, A.H.; Jana, S.; Kassiri, Z.; Gomez-Munoz, A.; Vance, D.E.; Jacobs, R.L.; van der Veen, J.N.
Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice
Biochim. Biophys. Acta
1865
14-25
2019
Mus musculus (Q61907)
Manually annotated by BRENDA team
Zufferey, R.
In vitro assay to measure phosphatidylethanolamine methyltransferase activity
J. Vis. Exp.
107
e53302
2016
Leishmania sp.
Manually annotated by BRENDA team
Jacobs, R.L.; Jiang, H.; Kennelly, J.P.; Orlicky, D.J.; Allen, R.H.; Stabler, S.P.; Maclean, K.N.
Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria
Mol. Genet. Metab.
120
325-336
2017
Mus musculus (Q61907), Mus musculus
Manually annotated by BRENDA team