Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.1.1.168 - 21S rRNA (uridine2791-2'-O)-methyltransferase and Organism(s) Saccharomyces cerevisiae and UniProt Accession P53123

for references in articles please use BRENDA:EC2.1.1.168
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme catalyses the methylation of uridine2791 of mitochondrial 21S rRNA.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Saccharomyces cerevisiae
UNIPROT: P53123
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
mitochondrial 21s rrna methyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
mitochondrial 21S rRNA methyltransferase
-
mitochondrial rRNA MTase 2
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:21S rRNA (uridine2791-2'-O)-methyltransferase
The enzyme catalyses the methylation of uridine2791 of mitochondrial 21S rRNA.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + uridine2791 in 21S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyluridine2791 in 21S rRNA
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + uridine2791 in 21S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyluridine2791 in 21S rRNA
show the reaction diagram
mitochondria of the yeast Saccharomyces cerevisiae assemble their ribosomes from ribosomal proteins, encoded by the nuclear genome (with one exception), and rRNAs of 15S and 21S, encoded by the mitochondrial genome. Unlike cytoplasmic rRNA, which is highly modified, mitochondrial rRNA contains only three modified nucleotides: a pseudouridine and two 2'-O-methylated riboses (Gm2270 and Um2791) located at the peptidyl transferase centre of 21S rRNA. Mrm2 is required for methylating U2791 of 21S rRNA
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
S-adenosyl-L-methionine
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G259R
complementation of a knockout strain with mutant G259R gene fails to rescue the respiratory phenotype
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
Mrm2p is induced in glycerol-containing medium
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pintard, L.; Bujnicki, J.M.; Lapeyre, B.; Bonnerot, C.
MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferase
EMBO J.
21
1139-1147
2002
Saccharomyces cerevisiae (P53123), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Garone, C.; DSouza, A.R.; Dallabona, C.; Lodi, T.; Rebelo-Guiomar, P.; Rorbach, J.; Donati, M.A.; Procopio, E.; Montomoli, M.; Guerrini, R.; Zeviani, M.; Calvo, S.E.; Mootha, V.K.; DiMauro, S.; Ferrero, I.; Minczuk, M.
Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome
Hum. Mol. Genet.
26
4257-4266
2017
Saccharomyces cerevisiae (P53123)
Manually annotated by BRENDA team