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IUBMB CommentsThe enzyme catalyses the 2'-O-methylation of the universally conserved U2552 in the A loop of 23S rRNA .
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
+
uridine2552 in 23S rRNA
=
+
2'-O-methyluridine2552 in 23S rRNA
Synonyms
ftsj2, mj0697, heat shock protein rrmj,
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S-adenosyl-L-methionine:23S rRNA (uridine2552-2'-O)-methyltransferase
The enzyme catalyses the 2'-O-methylation of the universally conserved U2552 in the A loop of 23S rRNA [3].
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Adenocarcinoma of Lung
FTSJ2, a Heat Shock-Inducible Mitochondrial Protein, Suppresses Cell Invasion and Migration.
Carcinogenesis
MiR-542-3p exerts tumor suppressive functions in non-small cell lung cancer cells by upregulating FTSJ2.
Carcinoma, Non-Small-Cell Lung
FTSJ2, a Heat Shock-Inducible Mitochondrial Protein, Suppresses Cell Invasion and Migration.
Carcinoma, Non-Small-Cell Lung
MiR-542-3p exerts tumor suppressive functions in non-small cell lung cancer cells by upregulating FTSJ2.
Lung Neoplasms
FTSJ2, a Heat Shock-Inducible Mitochondrial Protein, Suppresses Cell Invasion and Migration.
Lung Neoplasms
Integrative genomic and gene expression analysis of chromosome 7 identified novel oncogene loci in non-small cell lung cancer.
Lung Neoplasms
MiR-542-3p exerts tumor suppressive functions in non-small cell lung cancer cells by upregulating FTSJ2.
Neoplasms
FTSJ2, a Heat Shock-Inducible Mitochondrial Protein, Suppresses Cell Invasion and Migration.
Neoplasms
Identification and characterization of FTSJ2, a novel human nucleolar protein homologous to bacterial ribosomal RNA methyltransferase.
Neoplasms
MiR-542-3p exerts tumor suppressive functions in non-small cell lung cancer cells by upregulating FTSJ2.
Rhabdomyosarcoma
FTSJ2, a Heat Shock-Inducible Mitochondrial Protein, Suppresses Cell Invasion and Migration.
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UniProt
brenda
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transcripts are abundant
brenda
transcripts are abundant
brenda
transcripts are abundant
brenda
transcripts are abundant
brenda
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brenda
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MRM2_HUMAN
246
0
27424
Swiss-Prot
-
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24700
x * 24700, calculated
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Ching, Y.P.; Zhou, H.J.; Yuan, J.G.; Qiang, B.Q.; Kung Hf, H.F.; Jin, D.Y.
Identification and characterization of FTSJ2, a novel human nucleolar protein homologous to bacterial ribosomal RNA methyltransferase
Genomics
79
2-6
2002
Homo sapiens (Q9UI43), Homo sapiens
brenda
2.1.1.166 23S rRNA (uridine2552-2'-O)-methyltransferase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
