Information on EC 2.1.1.12 - methionine S-methyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
2.1.1.12
-
RECOMMENDED NAME
GeneOntology No.
methionine S-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
ordered bi bi mechanism with S-adenosylmethionine the first reactant to bind and S-adenosylhomocysteine the last product to be released
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
methyl group transfer
-
-
-
-
methyl group transfer
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
dimethylsulfoniopropanoate biosynthesis I (Wollastonia)
-
-
dimethylsulfoniopropanoate biosynthesis II (Spartina)
-
-
S-methyl-L-methionine cycle
-
-
seleno-amino acid detoxification and volatilization I
-
-
seleno-amino acid detoxification and volatilization II
-
-
Selenocompound metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:L-methionine S-methyltransferase
Requires Zn2+ or Mn2+
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
methionine methyltransferase
-
-
-
-
methionine methyltransferase
-
-
methyltransferase, methionine S-
-
-
-
-
MMT
-
-
-
-
S-adenosyl methionine:methionine methyl transferase
-
-
-
-
S-adenosyl-L-methionine methyltransferase
-
recognized by sequence similarity as a putative S-adenosyl-L-methionine methyltransferase
S-adenosylmethionine transmethylase
-
-
-
-
S-adenosylmethionine-methionine methyltransferase
-
-
-
-
See1p
-
secretion and early endocytosis 1 protein
CAS REGISTRY NUMBER
COMMENTARY
9027-77-4
-
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
-
the first in vivo data identify Yil064p as a novel component of intracellular transport, methyltransferase activity is predicted
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
enzyme is involved in S-methylmethionine cycle
-
-
?
S-adenosyl-L-methionine + selenomethionine
S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + selenomethionine
S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
show the reaction diagram
-
key enzyme in volatilization of selenium
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
enzyme is involved in S-methylmethionine cycle
-
-
?
S-adenosyl-L-methionine + selenomethionine
S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
show the reaction diagram
-
key enzyme in volatilization of selenium
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Zn2+
-
enzyme requires 0.1 mM Zn2+ or 1 mM Mn2+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
3-(methylthio)propanol
-
-
3-(methylthio)propionate
-
-
3-(methylthio)propionate methyl ester
-
-
3-(methylthio)propylamine
-
-
3-dimethylsulfoniopropionaldehyde
-
-
DL-2-hydroxy-4-(methylthio)butyrate
-
-
Gly-Met
-
-
L-ethionine
-
-
L-Met ethyl ester
-
-
L-Met methyl ester
-
-
L-Met p-nitroanilide
-
-
L-Methioninamide
-
-
L-methioninol
-
-
N-2,4-dinitrophenyl-DL-Met
-
-
N-formyl-L-Met
-
-
NEM
-
0.5 mM, 99% inhibition
p-hydroxymercuribenzoate
-
0.1 mM; 97% inhibition
S-adenosyl-L-homocysteine
-
-
S-methyl-L-methionine
-
-
seleno-L-methionine
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.14
L-Met
-
-
0.034
S-adenosyl-L-methionine
-
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.013
S-adenosyl-L-homocysteine
-
-
0.226
S-methyl-L-methionine
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
-
additional information
-
quick, simple, and specific method for measuring enzyme activity
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.7 - 7.3
-
about 60% of activity maximum at pH 5.7 and pH 7.3
5.8 - 9
-
about 50-55% of optimal activity at pH 5.8 and 9.0, only 1% of optimal activity at pH 5.0
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
activity does not change significantly during the first 2 d of germination, increases during the 3rd and 4th day
Manually annotated by BRENDA team
additional information
-
no activity in the root or endosperm
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
28000
-
theoretical
701425
450000
-
gel filtration
485144
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
-
x * 115000, SDS-PAGE
tetramer
-
4 * 115000, SDS-PAGE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
4
-
complete inactivation after 1 week
485144
25
-
complete inactivation after 24 h
485144
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20 C, complete inactivation after flash freezing in liquid N2
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
-
expressed in Escherichia coli
-