Information on EC 2.1.1.12 - methionine S-methyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
2.1.1.12
-
RECOMMENDED NAME
GeneOntology No.
methionine S-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
ordered bi bi mechanism with S-adenosylmethionine the first reactant to bind and S-adenosylhomocysteine the last product to be released
-
S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
methyl group transfer
-
-
-
-
methyl group transfer
-
-
PATHWAY
KEGG Link
MetaCyc Link
dimethylsulfoniopropionate biosynthesis I (Wollastonia)
-
dimethylsulfoniopropionate biosynthesis II (Spartina)
-
S-methylmethionine cycle
-
seleno-amino acid detoxification and volatilization I
-
seleno-amino acid detoxification and volatilization II
-
Selenocompound metabolism
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:L-methionine S-methyltransferase
Requires Zn2+ or Mn2+
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
methionine methyltransferase
-
-
-
-
methionine methyltransferase
-
-
methyltransferase, methionine S-
-
-
-
-
MMT
-
-
-
-
S-adenosyl methionine:methionine methyl transferase
-
-
-
-
S-adenosyl-L-methionine methyltransferase
-
recognized by sequence similarity as a putative S-adenosyl-L-methionine methyltransferase
S-adenosylmethionine transmethylase
-
-
-
-
S-adenosylmethionine-methionine methyltransferase
-
-
-
-
See1p
-
secretion and early endocytosis 1 protein
CAS REGISTRY NUMBER
COMMENTARY
9027-77-4
-
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
physiological function
-
the first in vivo data identify Yil064p as a novel component of intracellular transport, methyltransferase activity is predicted
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
enzyme is involved in S-methylmethionine cycle
-
-
?
S-adenosyl-L-methionine + selenomethionine
S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + selenomethionine
S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
show the reaction diagram
-
key enzyme in volatilization of selenium
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
show the reaction diagram
-
enzyme is involved in S-methylmethionine cycle
-
-
?
S-adenosyl-L-methionine + selenomethionine
S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
show the reaction diagram
-
key enzyme in volatilization of selenium
-
?
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Zn2+
-
enzyme requires 0.1 mM Zn2+ or 1 mM Mn2+
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
3-(methylthio)propanol
-
-
3-(methylthio)propionate
-
-
3-(methylthio)propionate methyl ester
-
-
3-(methylthio)propylamine
-
-
3-dimethylsulfoniopropionaldehyde
-
-
DL-2-hydroxy-4-(methylthio)butyrate
-
-
L-Ethionine
-
-
L-Met ethyl ester
-
-
L-Met methyl ester
-
-
L-Met p-nitroanilide
-
-
L-Methioninamide
-
-
L-methioninol
-
-
N-2,4-dinitrophenyl-DL-Met
-
-
N-formyl-L-Met
-
-
NEM
-
0.5 mM, 99% inhibition
p-hydroxymercuribenzoate
-
0.1 mM; 97% inhibition
S-adenosyl-L-homocysteine
-
-
S-methyl-L-methionine
-
-
seleno-L-methionine
-
-
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.14
-
L-Met
-
-
0.034
-
S-adenosyl-L-methionine
-
-
Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.013
-
S-adenosyl-L-homocysteine
-
-
0.226
-
S-methyl-L-methionine
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
0.506
-
-
-
additional information
-
-
-
additional information
-
-
quick, simple, and specific method for measuring enzyme activity
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5.7
7.3
-
about 60% of activity maximum at pH 5.7 and pH 7.3
5.8
9
-
about 50-55% of optimal activity at pH 5.8 and 9.0, only 1% of optimal activity at pH 5.0
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
-
activity does not change significantly during the first 2 d of germination, increases during the 3rd and 4th day
Manually annotated by BRENDA team
additional information
-
no activity in the root or endosperm
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
28000
-
-
theoretical
450000
-
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
?
-
x * 115000, SDS-PAGE
tetramer
-
4 * 115000, SDS-PAGE
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
4
-
-
complete inactivation after 1 week
25
-
-
complete inactivation after 24 h
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
-20 C, complete inactivation after flash freezing in liquid N2
-
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
expression in Escherichia coli
-
expressed in Escherichia coli
-