Information on EC 2.1.1.11 - magnesium protoporphyrin IX methyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
2.1.1.11
-
RECOMMENDED NAME
GeneOntology No.
magnesium protoporphyrin IX methyltransferase
PATHWAY
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
-
chlorophyllide a biosynthesis I (aerobic, light-dependent)
-
chlorophyllide a biosynthesis II (anaerobic)
-
chlorophyllide a biosynthesis III (aerobic, light independent)
-
Metabolic pathways
-
Porphyrin and chlorophyll metabolism
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
(-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase
-
-
-
-
ChlM
B5U883
-
ChlM
Synechocystis sp. PCC6803
-
-
-
magnesium protoporphyrin IX methyltransferase
-
-
-
-
magnesium protoporphyrin IX methyltransferase
-
-
magnesium protoporphyrin methyltransferase
-
-
magnesium protoporphyrin methyltransferase
Synechocystis sp. PCC6803
-
-
-
magnesium protoporphyrin O-methyltransferase
-
-
-
-
methyltransferase, magnesium protoporphyrin
-
-
-
-
Mg-protoporphyrin IX methyltransferase
-
-
Mg-protoporphyrin IX methyltransferase
-
-
Mg-protoporphyrin IX methyltransferase
B5U883
-
MgPIXMT protein
-
-
S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9029-82-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
; chlm mutant (ABN42 line) of the ecotype Wassilewskija (WS)
-
-
Manually annotated by BRENDA team
formerly Chlorobium tepidum
-
-
Manually annotated by BRENDA team
strain PCC6803
-
-
Manually annotated by BRENDA team
recombinant enzyme
-
-
Manually annotated by BRENDA team
Synechocystis sp. PCC6803
PCC6803
-
-
Manually annotated by BRENDA team
Synechocystis sp. PCC6803
strain PCC6803
-
-
Manually annotated by BRENDA team
TURNOVER NUMBER [1/s]
TURNOVER NUMBER MAXIMUM[1/s]
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.003
-
magnesium deuteroporphyrin
P26236
determined using 250 microM S-adenosyl-L-methionine
0.04
-
magnesium protoporphyrin
P26236
determined using 250 microM S-adenosyl-L-methionine
0.14
-
magnesium protoporphyrin
-
concentrations between 0.3 and 30 microM in the presence of 50 nM enzyme
0.0002
-
protoporphyrin
-
concentrations between 1 and 30 microM in the presence of 200 nM enzyme
0.018
-
zinc protoporphyrin
P26236
determined using 250 microM S-adenosyl-L-methionine
Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.00045
-
magnesium protoporphyrin monomethyl ester
P26236
non-competitive product inhibition, magnesium deuteroporphyrin as substrate
0.00061
-
magnesium protoporphyrin monomethyl ester
P26236
non-competitive product inhibition, S-adenosyl-L-methionine as substrate
0.121
-
S-adenosyl-L-homocysteine
P26236
non-competitive, magnesium protoporphyrin as substrate
0.141
-
S-adenosyl-L-homocysteine
P26236
non-competitive, S-adenosyl-L-methionine as substrate
GENERAL STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
phosphatidylglycerol stabilizes enzymatic activity causing disaggregation to lower molecular mass forms
P26236
ENGINEERING
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
L271P
-
naturally occuring mutation, Mg-protoporphyrin IX accumulated in the mutant, a low activity of the mutant protein is not excluded