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Information on EC 2.1.1.107 - uroporphyrinogen-III C-methyltransferase and Organism(s) Methanobacterium ivanovii and UniProt Accession P29564

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2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.107 uroporphyrinogen-III C-methyltransferase

IUBMB Comments

This enzyme catalyses two sequential methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2. It is the first of three steps leading to the formation of siroheme from uroporphyrinogen III. The second step involves an NAD+-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76, precorrin-2 dehydrogenase) and the third step involves the chelation of Fe2+ to sirohydrochlorin to form siroheme (EC 4.99.1.4, sirohydrochlorin ferrochelatase). In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalysed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirA being responsible for the above reaction. Also involved in the biosynthesis of cobalamin.

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Methanobacterium ivanovii

UNIPROT: P29564

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Word Map

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2.1.1.107
precorrin-2
siroheme
denitrificans
cobalamin
nitrite
sirohydrochlorin
tetrapyrrole
chelatase
ferrochelatase
corrin
transmethylation
corrinoid
dissimilatory
ferrochelation
analysis

The taxonomic range for the selected organisms is: Methanobacterium ivanovii
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Reaction Schemes

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S-adenosyl-L-methionine

uroporphyrinogen III

S-adenosyl-L-homocysteine

precorrin-2

Synonyms

uroporphyrinogen iii methyltransferase, s-adenosyl-l-methionine:uroporphyrinogen iii methyltransferase, uroporphyrinogen iii methylase, s-adenosyl-l-methionine uroporphyrinogen iii methyltransferase, sam-dependent uroporphyrinogen iii methyltransferase, uroporphyrinogen-iii c-methyltransferase, sirohaem synthase, uroporphyrinogen iii synthase/methyltransferase, s-adenosyl-l-methionine-dependent uroporphyrinogen iii methyltransferase, uroporphyrinogen iii c-methyltransferase, show all synonyms