Information on EC 1.97.1.10 - thyroxine 5'-deiodinase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
1.97.1.10
-
RECOMMENDED NAME
GeneOntology No.
thyroxine 5'-deiodinase
PATHWAY
KEGG Link
MetaCyc Link
thyroid hormone metabolism I (via deiodination)
-
thyroid hormone metabolism II (via conjugation and/or degradation)
-
SYSTEMATIC NAME
IUBMB Comments
acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)
The enzyme activity has only been demonstrated in the direction of 5'-deiodination, which renders the thyroid hormone more active. The enzyme consists of type I and type II enzymes, both containing selenocysteine, but with different kinetics. For the type I enzyme the first reaction is a reductive deiodination converting the -Se-H group of the enzyme into an -Se-I group; the reductant then reconverts this into -Se-H, releasing iodide.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5DI
-
-
-
-
5DII
-
-
-
-
5DIII
-
-
-
-
D1 5'-deiodinase
-
-
D2 5'-deiodinase
-
-
diiodothyronine 5'-deiodinase
-
-
-
-
Dio
-
gene name
DIO1
P49895
-
DIO1
Q61153
-
DIO2
-
-
DIO2
Q92813
-
DIO2
-
-
DIO2
-
gene name
DIOI
-
-
-
-
DIOII
-
-
-
-
DIOIII
-
-
-
-
EC 3.8.1.4
-
-
formerly
-
ID-2
-
-
ID-3
-
-
iodothyronine 5'-deiodinase
-
-
iodothyronine 5'-deiodinase
-
iodothyronine 5'-deiodinase type
iodothyronine 5'-deiodinase
-
isoenzymes type I (D1) and type II (D2)
iodothyronine 5'-deiodinase
-
isoenzymes type I (D1) and type II (D2); type II, no selenoprotein, induced by bt2cAMP and hydrocortisone (ED50 4nM); type I, selenoprotein, inducible by T3 (higher synthesis) and angiotensin II (positive chronotropic effect in myocard)
iodothyronine 5'-deiodinase
-
type I, selenoprotein, inducible by T3 (higher synthesis) and angiotensin II (positive chronotropic effect in myocard)
iodothyronine 5'-deiodinase
-
type II, no selenoprotein, induced by bt2cAMP and hydrocortisone (ED50 4nM)
Iodothyronine 5'-monodeiodinase
-
isoenzyme type I
iodothyronine 5-deiodinase
-
iodothyronine 5-deiodinase type
iodothyronine inner ring monodeiodinase
-
isoenzyme type III
iodothyronine inner ring monodeiodinase
-
-
iodothyronine outer ring monodeiodinase
-
-
-
-
L-thyroxine iodohydrolase (reducing)
-
-
-
-
thyroxine 5-deiodinase
-
-
-
-
Thyroxine deiodinase
-
-
-
-
type 1 5'-deiodinase
-
-
type 1 deiodinase
-
-
type 1 deiodinase
Q61153
-
type 1 deiodinase
-
-
Type 1 DI
-
-
-
-
type 1 iodothyronine deiodinase
-
-
type 1 iodothyronine deiodinase
P49895
-
type 1 iodothyronine deiodinase
Q61153
-
type 1 iodothyronine deiodinase
-
-
type 2 5'-deiodinase
-
-
type 2 deiodinase
-
-
type 2 deiodinase
Q92813
-
type 2 deiodinase
-
-
type 2 deiodinase
-
-
type 2 deiodinase
Q9Z148
-
type 2 deiodinase
Q9Z1Y9
-
type 2 deiodinase
-
-
Type 2 DI
-
-
-
-
type 2 iodothyronine deiodinase
-
-
type 2 iodothyronine deiodinase
Q92813
-
type 2 iodothyronine deiodinase
-
-
type 2 iodothyronine deiodinase
-
-
type 2 iodothyronine deiodinase
-
-
type 3 deiodinase
-
-
Type 3 DI
-
-
-
-
type I iodothyronine 5'-deiodinase
-
-
type I iodothyronine deiodinase
-, O42411
-
type I iodothyronine deiodinase
-
-
type I iodothyronine deiodinase
P24389
-
type I-like deiodinase
-
-
type II iodothyronine deiodinase
Q92813
-
type II iodothyronine deiodinase
Q9Z1Y9
-
type II-like deiodinase
-
-
Type-I 5'deiodinase
-
-
-
-
Type-II 5'deiodinase
-
-
-
-
Type-III 5'deiodinase
-
-
-
-
types 1 iodothyronine selenodeiodinase
P49895
-
types 2 iodothyronine selenodeiodinase
Q92813
-
XL-15
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
70712-46-8
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
type I and type II enzyme isoforms
-
-
Manually annotated by BRENDA team
type I enzyme
-
-
Manually annotated by BRENDA team
; tye I enzyme DIO1
SwissProt
Manually annotated by BRENDA team
; tye II enzyme DIO2
SwissProt
Manually annotated by BRENDA team
patients with thyroglobulin transport defect
-
-
Manually annotated by BRENDA team
three deiodinase isozymes Dio1, Dio2, and Dio3
-
-
Manually annotated by BRENDA team
type I and type II enzyme isoforms
-
-
Manually annotated by BRENDA team
Syrian hamster
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
three deiodinase isozymes Dio1, Dio2, and Dio3
-
-
Manually annotated by BRENDA team
type I and type II enzyme isoforms
-
-
Manually annotated by BRENDA team
wild-type and type 3 deiodinase knockdown mice
SwissProt
Manually annotated by BRENDA team
wild-type and type 3 deiodinase knockout mice, infected with Streptococcus pneumoniae
UniProt
Manually annotated by BRENDA team
comparison with placental 5-deiodinase EC 1.97.1.11
-
-
Manually annotated by BRENDA team
enzyme isoforms I, II, and III
-
-
Manually annotated by BRENDA team
male wistar rat
-
-
Manually annotated by BRENDA team
male, Wistar, hypothyroidism and hyperthyroidism is induced by diet
-
-
Manually annotated by BRENDA team
type I and type II enzyme isoforms
-
-
Manually annotated by BRENDA team
Wistar, subjected to 40% food restriction
-
-
Manually annotated by BRENDA team
overview
-
-
Manually annotated by BRENDA team
Rattus norvegicus
-
-
Manually annotated by BRENDA team
type I and type II enzyme isoforms
-
-
Manually annotated by BRENDA team
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.5
8
-
-
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
49900
-
-
gel filtration
55400
-
-
type I, sucrose density gradient centrifugation and gel filtration
56000
-
-
SDS-PAGE
198700
-
-
type II, sucrose density gradient centrifugation and gel filtration
200000
-
-
-
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
4
-
-
inactivation after 30 min
56
-
-
inactivation after 30 min
60
-
-
inactivation after 30 min
GENERAL STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
activity mostly lost during purification procedures, catalytic activity lost in detergent solution
-
very short lifetime in vivo of isoenzyme type II (D2) from brain
-
Renatured/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
partly reconstitution of activity of delipinated purified thyronine 5'-deiodinase from liver microsomes in soybean phospholipids
-