Information on EC 1.8.99.1 - sulfite reductase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
1.8.99.1
deleted entry. Now covered by EC 1.8.1.2, assimilatory sulfite reductase (NADPH) and EC 1.8.7.1, assimilatory sulfite reductase (ferredoxin).
RECOMMENDED NAME
GeneOntology No.
sulfite reductase
-
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
-
dissimilatory sulfite reductase mutants incapable of complete substrate oxidation oxidize sulfide and thiosulfate about twice as fast as the wild type, while having only slightly lower growth rates (70-80% of wild type)
malfunction
-
enzyme downregulation causes severe adaptive reactions of primary and secondary metabolism. Seedlings with 14% transcript levels compared with the wild type are early seedling lethal, while seedlings having 44% transcript levels are viable but strongly retarded in growth. Enzyme downregulation result in a higher sensitivity toward cadmium (2.6fold)
metabolism
-
sulfur globule oxidation is strictly dependent on the dissimilatory sulfite reductase (DSR). The DSR system is dispensable in environments with sufficiently high sulfide concentrations
physiological function
-
the enzyme catalyzes the terminal step in the reduction of sulfate to sulfide
physiological function
-
optimal enzyme activity is essential for normal development growth
PDB
SCOP
CATH
ORGANISM
UNIPROT
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)