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Information on EC 1.8.5.4 - bacterial sulfide:quinone reductase and Organism(s) Schizosaccharomyces pombe and UniProt Accession O94284

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IUBMB Comments
Contains FAD. Ubiquinone, plastoquinone or menaquinone can act as acceptor in different species. In some organisms the enzyme catalyses the formation of sulfur globules. It repeats the catalytic cycle without releasing the product, producing a polysulfide of up to 10 sulfur atoms. The reaction stops when the maximum length of the polysulfide that can be accommodated in the sulfide oxidation pocket is achieved. The enzyme also plays an important role in anoxygenic bacterial photosynthesis. cf. EC 1.8.5.8, sulfide quinone oxidoreductase.
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Schizosaccharomyces pombe
UNIPROT: O94284
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The taxonomic range for the selected organisms is: Schizosaccharomyces pombe
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
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n
HS-
+
n
quinone
=
polysulfide
+
n
quinol
n
+
n
=
polysulfide
+
n
Synonyms
sulfide:quinone oxidoreductase, sulfide quinone oxidoreductase, sqrdl, sulfide quinone reductase, sulfide-quinone reductase, sulfide-quinone oxidoreductase, ct1087, trsqrf, iii sqr, cpsqr, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
sulfide-quinone oxidoreductase
-
sulfide:quinone oxidoreductase
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SYSTEMATIC NAME
IUBMB Comments
sulfide:quinone oxidoreductase
Contains FAD. Ubiquinone, plastoquinone or menaquinone can act as acceptor in different species. In some organisms the enzyme catalyses the formation of sulfur globules. It repeats the catalytic cycle without releasing the product, producing a polysulfide of up to 10 sulfur atoms. The reaction stops when the maximum length of the polysulfide that can be accommodated in the sulfide oxidation pocket is achieved. The enzyme also plays an important role in anoxygenic bacterial photosynthesis. cf. EC 1.8.5.8, sulfide quinone oxidoreductase.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
n H2S + n quinone
polysulfide + n quinol
show the reaction diagram
-
-
-
?
sulfide + ubiquinone
? + ubiquinol
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
n H2S + n quinone
polysulfide + n quinol
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
enzyme Sqr knockout leads to morphological changes and functional deficiencies of mitochondria and apoptosis in Schizosaccharomyces pombe. The Sqr knockout strain displays the same phenotypes as the cysteine-synthesis-deficient strain. Cysteine addition complements the effects caused by Sqr knockout. Sqr knockout also results in physiological changes. The DELTAsqr strain shows reduced cell viability compared to the wild-type strain when cultivated in YES medium. There are more cells of early apoptosis in DELTAsqr culture than that in wild-type culture. Sqr knockout impaires mitochondrial health. Phenotypes and transcription and metabolism changes caused by sqr knockout, overview
metabolism
in Schizosaccharomyces pombe, Sqr is the main reactive sulfur species (RSS) producer in mitochondria, and RSS instead of H2S is used by cysteine synthase to synthesize cysteine. In terms of RSS metabolism, Schizosaccharomyces pombe does not contain genes encoding cystathionine beta-synthase (Cbs), cystathionine gamma-lyase (Cse), cysteinyl-tRNA synthetase 2 (Crs2), or persulfide dioxygenase (Pdo)
physiological function
sulfide:quinone oxidoreductase (Sqr), which oxidizes hydrogen sulfide to reactive sulfur species (RSS), is indispensable to mitochondria health in the eukaryotic model microorganism Schizosaccharomyces pombe. RSS play critical functions in the cell, such as signaling, redox homeostasis maintenance, and metabolic regulation
additional information
reactive sulfur species (RSS) include inorganic polysulfide (HSnH, n>2), organic polysulfide (RSnH, n>2), and polysulfane (RSnR, n>2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
construction and analysis of an enzyme knockout strain DELTAsqr, phenotypes, overview
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene ht2, quantitative RT-PCR enzyme expression analysis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Theissen, U.; Hoffmeister, M.; Grieshaber, M.; Martin, W.
Single eubacterial origin of eukaryotic sulfide:quinone oxidoreductase, a mitochondrial enzyme conserved from the early evolution of eukaryotes during anoxic and sulfidic times
Mol. Biol. Evol.
20
1564-1574
2003
Arenicola marina, Geukensia demissa, Heteromastus filiformis, Schizosaccharomyces pombe (O94284), Solemya reidi
Manually annotated by BRENDA team
Zhang, X.; Xin, Y.; Chen, Z.; Xia, Y.; Xun, L.; Liu, H.
Sulfide-quinone oxidoreductase is required for cysteine synthesis and indispensable to mitochondrial health
Redox Biol.
47
102169
2021
Schizosaccharomyces pombe (O94284), Schizosaccharomyces pombe ATCC 24843 (O94284), Schizosaccharomyces pombe 972 (O94284)
Manually annotated by BRENDA team