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Information on EC 1.8.4.B3 - thioredoxin-independent methionine sulfoxide reductases B and Organism(s) Homo sapiens and UniProt Accession Q8IXL7

for references in articles please use BRENDA:EC1.8.4.B3
preliminary BRENDA-supplied EC number
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Homo sapiens
UNIPROT: Q8IXL7
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The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
hmsrb2, hmsrb3, ntmsrb1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-methionine (R)-S-sulfoxide + thionein
L-methionine + thionein disulfide + H2O
show the reaction diagram
-
-
-
?
L-methionine (R)-S-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide
show the reaction diagram
reduced thioredoxin is not an efficient reducing agent for hMsrB3. Less than 5% of the activity with dithiothreitol
-
-
?
L-methionine (R)-sulfoxide + dithiothreitol
L-methionine + dithiothreitol disulfide
show the reaction diagram
-
-
-
?
L-methionine (R)-S-sulfoxide + dithiothreitol
L-methionine + dithiothreitol disulfide + H2O
show the reaction diagram
-
-
-
?
L-methionine (R)-S-sulfoxide + thionein
L-methionine + thionein disulfide + H2O
show the reaction diagram
-
-
-
?
L-methionine (R)-S-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
reduced thioredoxin is not an efficient reducing agent for hMsrB2. Less than 5% of the activity with dithiothreitol
-
-
?
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MSRB3_HUMAN
192
0
20702
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sagher, D.; Brunell, D.; Hejtmancik, J.F.; Kantorow, M.; Brot, N.; Weissbach, H.
Thionein can serve as a reducing agent for the methionine sulfoxide reductases
Proc. Natl. Acad. Sci. USA
103
8656-8661
2006
Homo sapiens (Q8IXL7), Homo sapiens (Q9Y3D2), Homo sapiens
Manually annotated by BRENDA team