Information on EC 1.8.3.4 - methanethiol oxidase

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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
1.8.3.4
-
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RECOMMENDED NAME
GeneOntology No.
methanethiol oxidase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + H2O2
show the reaction diagram
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
dimethyl sulfide degradation I
-
-
Sulfur metabolism
-
-
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SYSTEMATIC NAME
IUBMB Comments
methanethiol:oxygen oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
112821-28-0
-
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain EG
-
-
Manually annotated by BRENDA team
strain EG
-
-
Manually annotated by BRENDA team
strain TK-m
-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ethyl mercaptan + O2 + H2O
acetaldehyde + H2S + H2O2
show the reaction diagram
methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
show the reaction diagram
sulfide + O2
sulfur + H2O2
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
methanethiol + O2 + H2O
formaldehyde + H2S + H2O2
show the reaction diagram
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(NH4)2SO4
-
-
cyanide
ethyl mercaptan
K2SO4
-
inhibition at concentration below 200 mM, original activity is recovered at 200 mM
methanethiol
methylamine
-
-
NaCl
-
inhibition at concentration below 200 mM, original activity is recovered at 200 mM
Sulfide
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.018
ethyl mercaptan
-
-
0.005 - 0.0313
methanethiol
0.06
Sulfide
-
-
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.04
cyanide
-
-
0.008 - 0.042
methanethiol
1.4
methylamine
-
-
0.09
Sulfide
-
-
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
29000
-
gel filtration
40000 - 50000
-
gel filtration
40000
-
1 * 40000, SDS-PAGE
49000
-
1 * 49000, SDS-PAGE
64500
-
x * 64500, SDS-PAGE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 64500, SDS-PAGE
monomer
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50
-
10 min, stable
65
-
10 min, complete loss of activity
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20�C, stable for months
-
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.8.3.4)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)