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Disease on EC 1.8.1.9 - thioredoxin-disulfide reductase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
22q11 Deletion Syndrome
Mitochondrial Function in 22q11 Deletion Syndrome.
Acquired Immunodeficiency Syndrome
Thioredoxin reductase as a pathophysiological factor and drug target.
Thioredoxin reductase.
Acute Kidney Injury
Ifosfamide induces acute renal failure via inhibition of the thioredoxin reductase activity.
Acute Lung Injury
Club Cell Heme Oxygenase-1 Deletion: Effects in Hyperoxia-Exposed Adult Mice.
Adenocarcinoma
Antineoplastic effects of auranofin in human pancreatic adenocarcinoma preclinical models.
Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades.
Discoveries of vitamin B12 and selenium enzymes.
Expression profiles of thioredoxin family proteins in human lung cancer tissue: correlation with proliferation and differentiation.
Potential relationship between the selenoproteome and cancer.
Adenocarcinoma of Lung
A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity.
Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo.
Heparin-binding properties of selenium-containing thioredoxin reductase from HeLa cells and human lung adenocarcinoma cells.
High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy.
Potential relationship between the selenoproteome and cancer.
Production of functional human selenocysteine-containing KDRF/thioredoxin reductase in E. coli.
Adenoma
Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer.
Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma.
Alzheimer Disease
Decreased thioredoxin and increased thioredoxin reductase levels in Alzheimer's disease brain.
Amebiasis
Entamoeba histolytica: identification of thioredoxin-targeted proteins and analysis of serine acetyltransferase-1 as a prototype example.
Formation of oxidised (OX) proteins in Entamoeba histolytica exposed to auranofin and consequences on the parasite virulence.
In vitro antiamoebic activity evaluation and docking studies of metronidazole-triazole hybrids.
Thioredoxin reductase as a pathophysiological factor and drug target.
Amyloidosis
Differential expression of MAP3K7 and TROPONIN C proteins and related perturbations in renal amyloidosis.
Amyotrophic Lateral Sclerosis
Thioredoxin reductase 1 haplotypes modify familial amyotrophic lateral sclerosis onset.
Aortic Aneurysm, Abdominal
Associations and interactions between variants in selenoprotein genes, selenoprotein levels and the development of abdominal aortic aneurysm, peripheral arterial disease, and heart failure.
Arthritis
Auranofin, a thioredoxin reductase inhibitor, causes platelet death through calcium overload.
Crossroads of Cancer and HIV-1: Pathways to a Cure for HIV.
Arthritis, Rheumatoid
Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells.
Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer.
Drug repurposing for gastrointestinal stromal tumor.
High redox thioredoxin but low thioredoxin reductase activities in the serum of patients with rheumatoid arthritis.
Plasma and Synovial Fluid TrxR Levels are Correlated With Disease Risk and Severity in Patients With Rheumatoid Arthritis.
Thioredoxin reductase as a pathophysiological factor and drug target.
Aspergillosis
Antibody specific to thioredoxin reductase as a new biomarker for serodiagnosis of invasive aspergillosis in non-neutropenic patients.
Immunoproteomics based identification of thioredoxin reductase GliT and novel Aspergillus fumigatus antigens for serologic diagnosis of invasive aspergillosis.
The Essential Thioredoxin Reductase of the Human Pathogenic Mold Aspergillus fumigatus Is a Promising Antifungal Target.
Asthma
Increased anti-oxidant enzyme activity and biological oxidation in placentae of pregnancies complicated by maternal asthma.
Astrocytoma
Expression of antioxidant enzymes in astrocytic brain tumors.
Tissue thioredoxin reductase-1 expression in astrocytomas of different grades.
Ataxia
The role of thioredoxin reductases in brain development.
Ataxia Telangiectasia
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Atherosclerosis
Selenium in the prevention of atherosclerosis and its underlying mechanisms.
Thioredoxin reductase 1 upregulates MCP-1 release in human endothelial cells.
Autoimmune Diseases
Synthesis of 5,5'-dithiobis(2-nitrobenzamides) as alternative substrates for trypanothione reductase and thioredoxin reductase: a microtiter colorimetric assay for inhibitor screening.
Thioredoxin reductase.
Babesiosis
Biochemical characterization of thioredoxin reductase from Babesia bovis.
Bacterial Infections
Thioredoxin reductase as a pathophysiological factor and drug target.
beta-Thalassemia
Thalassemia major patients using iron chelators showed a reduced plasma thioredoxin level and reduced thioredoxin reductase activity, despite elevated oxidative stress.
Blister
Defects in antioxidant defense and calcium transport in the epidermis of xeroderma pigmentosum patients.
Brain Neoplasms
Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections.
Thioredoxin System Protein Expression Is Associated with Poor Clinical Outcome in Adult and Paediatric Gliomas and Medulloblastomas.
Thioredoxin, glutathione and related molecules in tumors of the nervous system.
Breast Neoplasms
2-Tellurium-bridged ?-cyclodextrin, a thioredoxin reductase inhibitor, sensitizes human breast cancer cells to TRAIL-induced apoptosis through DR5 induction and NF-?B suppression.
A gold(I) phosphine complex selectively induces apoptosis in breast cancer cells: implications for anticancer therapeutics targeted to mitochondria.
Adipocytokines, inflammatory, epigenetic instability & angiogenesis biomarkers in type 2 diabetic Egyptian women with breast cancer.
Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer.
Cytotoxic and radiosensitising effects of a novel thioredoxin reductase inhibitor in breast cancer.
Cytotoxic, chemosensitizing and radiosensitizing effects of curcumin based on thioredoxin system inhibition in breast cancer cells: 2D vs. 3D cell culture system.
Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy.
Efficacy of novel methylenecyclohexenone derivatives as TrxR inhibitors in suppressing the proliferation and metastasis of human cancer cells.
Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer.
Gold(III) bis(thiosemicarbazonate) compounds in breast cancer cells: Cytotoxicity and thioredoxin reductase targeting.
Inhibition of Thioredoxin Reductase by Targeted Selenopolymeric Nanocarriers Synergizes the Therapeutic Efficacy of Doxorubicin in MCF7 Human Breast Cancer Cells.
Maintenance of S-nitrosothiol homeostasis plays an important role in growth suppression of estrogen receptor-positive breast tumors.
Methylseleninic acid (MSA) inhibits 17?-estradiol-induced cell growth in breast cancer T47D cells via enhancement of the antioxidative thioredoxin/ thioredoxin reductase system.
miR526b and miR655 Induce Oxidative Stress in Breast Cancer.
Multi-Targeted Anticancer Activity of Imidazolate Phosphane Gold(I) Compounds by Inhibition of DHFR and TrxR in Breast Cancer Cells.
Organotin complexes containing carboxylate ligands with maleimide and naphthalimide derived partial structures: TrxR inhibition, cytotoxicity and activity in resistant cancer cells.
Oxidative Stress Mediates through Apoptosis the Anticancer Effect of Phospho-Nonsteroidal Anti-Inflammatory Drugs: Implications for the Role of Oxidative Stress in the Action of Anticancer Agents.
pH-Sensitive Polymeric Nanoparticles with Gold(I) Compound Payloads Synergistically Induce Cancer Cell Death through Modulation of Autophagy.
Profilin-1 overexpression in MDA-MB-231 breast cancer cells is associated with alterations in proteomics biomarkers of cell proliferation, survival, and motility as revealed by global proteomics analyses.
Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer.
Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress.
Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy.
SEPP1 influences breast cancer risk among women with greater native american ancestry: the breast cancer health disparities study.
Sulforaphane, erucin, and iberin up-regulate thioredoxin reductase 1 expression in human MCF-7 cells.
Synergistic induction of apoptosis by combination treatment with mesupron and auranofin in human breast cancer cells.
Synthesis of mitochondria-targeted coumarin-3-carboxamide fluorescent derivatives: Inhibiting mitochondrial TrxR2 and cell proliferation on breast cancer cells.
Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer.
Targeting disseminated estrogen-receptor-positive breast cancer cells in bone marrow.
The Prognosis Of Peroxiredoxin Family In Breast Cancer.
The role of functional polymorphisms in oxidative stress-related genes on early-stage breast cancer survival.
The thioredoxin system in breast cancer cell invasion and migration.
Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.
Thioredoxin and thioredoxin reductase influence estrogen receptor {alpha} mediated gene expression in human breast cancer cells.
Thioredoxin reductase and cancer cell growth inhibition by organotellurium antioxidants.
Thioredoxin system: a model for determining novel lead molecules for breast cancer chemotherapy.
Wogonin induces cellular senescence in breast cancer via suppressing TXNRD2 expression.
Bronchopulmonary Dysplasia
Hyperoxia induces thioredoxin and thioredoxin reductase gene expression in lungs of premature baboons with respiratory distress and bronchopulmonary dysplasia.
The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms.
Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia.
Candidiasis
Microbicidal activity of neutrophils is inhibited by isolates from recurrent vaginal candidiasis (RVVC) caused by Candida albicans through fungal thioredoxin reductase.
Carcinogenesis
Conditional expression of 15-lipoxygenase-1 inhibits the selenoenzyme thioredoxin reductase: modulation of selenoproteins by lipoxygenase enzymes.
Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo.
Differential epigenetic and transcriptional profile in MCF-7 breast cancer cells exposed to cadmium.
Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent.
Identification of Michael Acceptor-Centric Pharmacophores with Substituents That Yield Strong Thioredoxin Reductase Inhibitory Character Correlated to Antiproliferative Activity.
Impact of trivalent arsenicals on selenoprotein synthesis.
Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation.
Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium.
Novel thioredoxin reductase inhibitor butaselen inhibits tumorigenesis by down-regulating programmed death-ligand 1 expression.
Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer.
Review: Exploring anticarcinogenic agents in a rat hepatocarcinogenesis model--focus on selenium and statins.
Simvastatin inhibits the core promoter of the TXNRD1 gene and lowers cellular TrxR activity in HepG2 cells.
Synthesis, SAR and biological evaluation of a novel series of 1-(2-chloroethyl)-1-nitroso-3-(2-(3-oxobenzoelenazol-2(3H)-yl)ethyl) urea: Organoselenium compounds for cancer therapy.
Targeting thioredoxin reductase by deoxyelephantopin from Elephantopus scaber triggers cancer cell apoptosis.
The thioredoxin system and cancer therapy: a review.
Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy.
Carcinoma
A thioredoxin reductase inhibitor induces growth inhibition and apoptosis in five cultured human carcinoma cell lines.
Applying the designed multiple ligands approach to inhibit dihydrofolate reductase and thioredoxin reductase for anti-proliferative activity.
Circ0120816 acts as an oncogene of esophageal squamous cell carcinoma by inhibiting miR-1305 and releasing TXNRD1.
Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo.
Differential expression of MAP3K7 and TROPONIN C proteins and related perturbations in renal amyloidosis.
Dose-biomarker-response modeling of the anticancer effect of ethaselen in a human non-small cell lung cancer xenograft mouse model.
Inhibition of thioredoxin reductase by lanthanum chloride.
Is selenium a potential treatment for cancer metastasis?
Motexafin Gadolinium for the Treatment of Metastatic Renal Cell Carcinoma: Phase II Study Results.
Organotin complexes containing carboxylate ligands with maleimide and naphthalimide derived partial structures: TrxR inhibition, cytotoxicity and activity in resistant cancer cells.
Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma.
Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II).
Potential relationship between the selenoproteome and cancer.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Redox protein expression predicts progression-free and overall survival in ovarian cancer patients treated with platinum-based chemotherapy.
The activity and tissue distribution of thioredoxin reductase in basal cell carcinoma.
The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo.
The Value of Thioredoxin Family Proteins and Proliferation Markers in Dysplastic and Malignant Gallbladders in Patients with Primary Sclerosing Cholangitis.
Thioredoxin is associated with proliferation, p53 expression and negative estrogen and progesterone receptor status in breast carcinoma.
Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells.
Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.
Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma.
Carcinoma, Basal Cell
The activity and tissue distribution of thioredoxin reductase in basal cell carcinoma.
Carcinoma, Ehrlich Tumor
The 58 kDa mouse selenoprotein is a BCNU-sensitive thioredoxin reductase.
Carcinoma, Hepatocellular
10H-3,6-Diazaphenothiazine-Induced, Caspases-Mediated Mitochondrial-Dependent Apoptosis on HepG2 Hepatocellular Carcinoma Cells and Suppressed Cancer Cells Invasion via Inhibiting Mitochondrial Thioredoxin Reductase Enzymatic Activities.
A new rhodium(I) NHC complex inhibits TrxR: In vitro cytotoxicity and in vivo hepatocellular carcinoma suppression.
Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase.
Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep3B cells by generation of reactive oxygen species.
Comparison of thioredoxin reductases from Novikoff ascites hepatoma cells and normal liver of rats.
Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo.
Differential thioredoxin reductase activity from human normal hepatic and hepatoma cell lines.
Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells.
Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase.
Induction of Oxidative Stress via Inhibition of Thioredoxin Reductase 1 is an Effective Therapeutic Approach for Hepatocellular Carcinoma.
Inhibition of Both Thioredoxin Reductase and Glutathione Reductase may Contribute to the Anticancer Mechanism of TH-302.
Inhibition of glutathione synthesis eliminates the adaptive response of ascitic hepatoma 22 cells to nedaplatin that targets thioredoxin reductase.
Inhibitory effects of thioredoxin reductase antisense RNA on the growth of human hepatocellular carcinoma cells.
Loss of activity of the selenoenzyme thioredoxin reductase causes induction of hepatic heme oxygenase-1.
miR-125b-5p inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma via targeting TXNRD1.
Nano red elemental selenium has no size effect in the induction of seleno-enzymes in both cultured cells and mice.
Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas.
PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway.
Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress.
Potential relationship between the selenoproteome and cancer.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.
SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC.
Synergy between sulforaphane and selenium in the up-regulation of thioredoxin reductase and protection against hydrogen peroxide-induced cell death in human hepatocytes
Synergy between sulforaphane and selenium in the up-regulation of thioredoxin reductase and protection against hydrogen peroxide-induced cell death in human hepatocytes.
Synthesis and biological evaluation of gold(III) Schiff base complexes for the treatment of hepatocellular carcinoma through attenuating TrxR activity.
Thioredoxin alters the matrix metalloproteinase/tissue inhibitors of metalloproteinase balance and stimulates human SK-N-SH neuroblastoma cell invasion.
Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element.
Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy.
Thioredoxin reductase: a novel, independent prognostic marker in patients with hepatocellular carcinoma.
Toxicological effects of thiomersal and ethylmercury: Inhibition of the thioredoxin system and NADP(+)-dependent dehydrogenases of the pentose phosphate pathway.
TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.
TXNRD1 Is an Unfavorable Prognostic Factor for Patients with Hepatocellular Carcinoma.
[Correlation of plasma thioredoxin reductase activity to growth of H22 hepatocellular carcinoma xenografts in Kunming mice.]
[Preliminary study on cellular status of selenium and oxidative stress in human hepatocellular carcinoma and normal liver]
Carcinoma, Lewis Lung
Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo.
Carcinoma, Non-Small-Cell Lung
Dose-biomarker-response modeling of the anticancer effect of ethaselen in a human non-small cell lung cancer xenograft mouse model.
Expression profiles of thioredoxin family proteins in human lung cancer tissue: correlation with proliferation and differentiation.
MicroRNA-124 regulates the radiosensitivity of non-small cell lung cancer cells by targeting TXNRD1.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Selenium-containing thioredoxin reductase inhibitor ethaselen sensitizes non-small cell lung cancer to radiotherapy.
Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway.
Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells.
The serum activity of thioredoxin reductases 1 (TrxR1) is correlated with the poor prognosis in EGFR wild-type and ALK negative non-small cell lung cancer.
Thioredoxin Reductase as a Novel and Efficient Plasma Biomarker for the Detection of Non-Small Cell Lung Cancer: a Large-scale, Multicenter study.
Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma.
Carcinoma, Ovarian Epithelial
BRCA1 deficiency increases the sensitivity of ovarian cancer cells to auranofin.
Carcinoma, Renal Cell
Motexafin Gadolinium for the Treatment of Metastatic Renal Cell Carcinoma: Phase II Study Results.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Squamous Cell
Differential expression of MAP3K7 and TROPONIN C proteins and related perturbations in renal amyloidosis.
Potential relationship between the selenoproteome and cancer.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells.
Cardiomyopathy, Dilated
Consequences of mutations and inborn errors of selenoprotein biosynthesis and functions.
Did a shared thioredoxin-reductase gene mutation lead to maternal peripartum cardiomyopathy and fatal dilated cardiomyopathy in her son? A case report.
Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function.
Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium.
Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protection.
Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy.
Cardiotoxicity
Cyclophosphamide-evoked heart failure involves pronounced co-suppression of cytoplasmic thioredoxin reductase activity and non-protein free thiol level.
Cardiovascular Diseases
Astaxanthin prevents changes in the activities of thioredoxin reductase and paraoxonase in hypercholesterolemic rabbits.
Distinctive Under-Expression Profile of Inflammatory and Redox Genes in the Blood of Elderly Patients with Cardiovascular Disease.
Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase.
Selenium supplementation does not improve vascular responsiveness in healthy North American men.
Selenoproteins and human health: Insights from epidemiological data.
Cataract
DNA hypermethylation-mediated downregulation of antioxidant genes contributes to the early onset of cataracts in highly myopic eyes.
Effects of Sodium Selenite on Oxidative Damage in the Liver, Kidney and Brain in a Selenite Cataract Rat Model.
Oral consumption of ?-glucosyl-hesperidin could prevent lens hardening, which causes presbyopia.
Sulforaphane-induced transcription of thioredoxin reductase in lens: possible significance against cataract formation.
Thioredoxin, thioredoxin reductase, and alpha-crystallin revive inactivated glyceraldehyde 3-phosphate dehydrogenase in human aged and cataract lens extracts.
Cerebrovascular Disorders
DNA Hypomethylation of the MPO Gene in Peripheral Blood Leukocytes Is Associated with Cerebral Stroke in the Acute Phase.
Chemical and Drug Induced Liver Injury
Genetic Variations in TXNRD1 as Potential Predictors of Drug-Induced Liver Injury.
Cholangiocarcinoma
Altered expression of thioredoxin reductase-1 in dysplastic bile ducts and cholangiocarcinoma in a hamster model.
Colonic Neoplasms
Bile acids mimic oxidative stress induced upregulation of thioredoxin reductase in colon cancer cell lines.
Cellular thioredoxin reductase activity is regulated by selenium.
Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer.
Curcuminoid WZ26, a TrxR1 inhibitor, effectively inhibits colon cancer cell growth and enhances cisplatin-induced cell death through the induction of ROS.
Enhancement of the efficacy of mitomycin C-mediated apoptosis in human colon cancer cells with RNAi-based thioredoxin reductase 1 deficiency.
Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators.
Isodeoxyelephantopin Inactivates Thioredoxin Reductase 1 and Activates ROS-Mediated JNK Signaling Pathway to Exacerbate Cisplatin Effectiveness in Human Colon Cancer Cells.
JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1.
Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells.
Potential relationship between the selenoproteome and cancer.
The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways.
Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.
Thioredoxin reductase 1 ablation sensitizes colon cancer cells to methylseleninate-mediated cytotoxicity.
Thioredoxin reductase 1 expression in colon cancer: discrepancy between in vitro and in vivo findings.
Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles.
Thioredxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest.
Colorectal Neoplasms
Aberrant expression of selenoproteins in the progression of colorectal cancer.
Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation.
Licochalcone a Induces ROS-Mediated Apoptosis through TrxR1 Inactivation in Colorectal Cancer Cells.
Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells.
Selenite induces apoptosis in colorectal cancer cells through interaction with thioredoxin reductase.
Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.
Congenital Abnormalities
Characterizing the effects of titanium dioxide and silver nanoparticles released from painted surfaces due to weathering on zebrafish (Danio rerio).
Corneal Dystrophies, Hereditary
[Oxidative stress in the pathogenesis of Fuchs endothelial corneal dystrophy].
Cystitis
Cyclophosphamide suppresses thioredoxin reductase in bladder tissue and its adaptive response via inductions of thioredoxin reductase and glutathione peroxidase.
Diabetes Mellitus
Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus.
Single nucleotide polymorphisms in the Trx2/TXNIP and TrxR2 genes of the mitochondrial thioredoxin antioxidant system and the risk of diabetic retinopathy in patients with Type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus.
Single nucleotide polymorphisms in the Trx2/TXNIP and TrxR2 genes of the mitochondrial thioredoxin antioxidant system and the risk of diabetic retinopathy in patients with Type 2 diabetes mellitus.
Diabetes, Gestational
miR?875?5p regulates IR and inflammation via targeting TXNRD1 in gestational diabetes rats.
Diabetic Retinopathy
Single nucleotide polymorphisms in the Trx2/TXNIP and TrxR2 genes of the mitochondrial thioredoxin antioxidant system and the risk of diabetic retinopathy in patients with Type 2 diabetes mellitus.
DiGeorge Syndrome
Haplotypic association spanning the 22q11.21 genes COMT and ARVCF with schizophrenia.
Diphtheria
Thioredoxin reductase inhibitor auranofin prevents membrane transport of diphtheria toxin into the cytosol and protects human cells from intoxication.
Drug Hypersensitivity
Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions.
Duodenal Ulcer
Deep-sea water containing selenium provides intestinal protection against duodenal ulcers through the upregulation of Bcl-2 and thioredoxin reductase 1.
Encephalomyelitis
Compensatory Neuroprotective Response of Thioredoxin Reductase against Oxidative-Nitrosative Stress Induced by Experimental Autoimmune Encephalomyelitis in Rats: Modulation by Theta Burst Stimulation.
Encephalomyelitis, Autoimmune, Experimental
Compensatory Neuroprotective Response of Thioredoxin Reductase against Oxidative-Nitrosative Stress Induced by Experimental Autoimmune Encephalomyelitis in Rats: Modulation by Theta Burst Stimulation.
Endometriosis
Association between the Genetic Variants of Glutathione Peroxidase 4 and Severity of Endometriosis.
Epilepsy
Changes in the Expression of Selenoproteins in Mesial Temporal Lobe Epilepsy Patients.
Epilepsy, Generalized
Consequences of mutations and inborn errors of selenoprotein biosynthesis and functions.
Homozygous mutation in TXNRD1 is associated with genetic generalized epilepsy.
Epilepsy, Temporal Lobe
Changes in the Expression of Selenoproteins in Mesial Temporal Lobe Epilepsy Patients.
Esophageal Squamous Cell Carcinoma
Circ0120816 acts as an oncogene of esophageal squamous cell carcinoma by inhibiting miR-1305 and releasing TXNRD1.
Fibrosarcoma
Cytotoxicity induced by inhibition of thioredoxin reductases via multiple signaling pathways: role of cytosolic phospholipase A(2)alpha-dependent and -independent release of arachidonic acid.
Is selenium a potential treatment for cancer metastasis?
Filariasis
A review on the druggability of a thiol-based enzymatic antioxidant thioredoxin reductase for treating filariasis and other parasitic infections.
Friedreich Ataxia
Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function.
Fuchs' Endothelial Dystrophy
[Oxidative stress in the pathogenesis of Fuchs endothelial corneal dystrophy].
Glaucoma
Association analysis of variants rs35934224 in TXNRD2 and rs6478746 in LMX1B in primary angle-closure and pseudoexfoliation glaucoma.
Mitochondrial function is impaired in the primary visual cortex in an experimental glaucoma model.
Glaucoma, Open-Angle
Association analysis of variants rs35934224 in TXNRD2 and rs6478746 in LMX1B in primary angle-closure and pseudoexfoliation glaucoma.
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.
Lack of Association Between Polymorphisms in TXNRD2 and LMX1B and Primary Open-Angle Glaucoma in a Saudi Cohort.
TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population.
Glioblastoma
Antiglioma activity of 2,2':6',2"-terpyridineplatinum(II) complexes in a rat model-Effects on cellular redox metabolism.
Human thioredoxin reductase is efficiently inhibited by (2,2':6',2' '-terpyridine)platinum(II) complexes. Possible implications for a novel antitumor strategy.
Inhibition of reductase systems by 2-AAPA modulates peroxiredoxin oxidation and mitochondrial function in A172 glioblastoma cells.
Intratumoral hemorrhage-related differences in the expression of vascular endothelial growth factor, basic fibroblast growth factor and thioredoxin reductase 1 in human glioblastoma.
New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Thioredoxin System Protein Expression Is Associated with Poor Clinical Outcome in Adult and Paediatric Gliomas and Medulloblastomas.
Tissue and Plasma Thioredoxin Reductase Expressions in Patients with Glioblastoma Multiforme.
Tissue thioredoxin reductase-1 expression in astrocytomas of different grades.
Glioma
(1-4)-Thiodisaccharides as anticancer agents. Part 5. Evaluation of anticancer activity and investigation of mechanism of action.
Efficient identification of novel anti-glioma lead compounds by machine learning models.
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin ?-2 Expression, and Induce Antitumor Effects against Human Glioma.
Is selenium a potential treatment for cancer metastasis?
Novel TrxR1 Inhibitors Show Potential for Glioma Treatment by Suppressing the Invasion and Sensitizing Glioma Cells to Chemotherapy.
TGF-?-induced hCG-? regulates redox homeostasis in glioma cells.
Thioredoxin System Protein Expression Is Associated with Poor Clinical Outcome in Adult and Paediatric Gliomas and Medulloblastomas.
TIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport.
Heart Failure
Cyclophosphamide-evoked heart failure involves pronounced co-suppression of cytoplasmic thioredoxin reductase activity and non-protein free thiol level.
Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium.
Thioredoxin Reductase 2 (Txnrd2) Regulates Mitochondrial Integrity in the Progression of Age-Related Heart Failure.
Hermanski-Pudlak Syndrome
Regulation of thioredoxin reductase by calcium in Hermansky-Pudlak syndrome.
Thioredoxin reductase activity in Hermansky-Pudlak syndrome: a method for identification of putative heterozygotes.
[Hermansky-Pudlak syndrome]
HIV Infections
Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120.
Hyperglycemia
Hyperglycemia in a type 1 Diabetes Mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain.
Hypersensitivity
A novel NADPH thioredoxin reductase, localized in the chloroplast, which deficiency causes hypersensitivity to abiotic stress in Arabidopsis thaliana.
Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions.
Hypertension
Augmented S-nitrosylation contributes to impaired relaxation in angiotensin II hypertensive mouse aorta: role of thioredoxin reductase.
THIOREDOXIN REDUCTASE INHIBITION REDUCES RELAXATION BY INCREASING OXIDATIVE STRESS AND S-NITROSYLATION IN MOUSE AORTA.
Hypopigmentation
Thioredoxin reductase. Role in free radical reduction in different hypopigmentation disorders.
Hypothyroidism
Diphenyl Diselenide Modulates Gene Expression of Antioxidant Enzymes in the Cerebral Cortex, Hippocampus and Striatum of Female Hypothyroid Rats.
Infections
A review on the druggability of a thiol-based enzymatic antioxidant thioredoxin reductase for treating filariasis and other parasitic infections.
Auranofin inactivates Trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo.
Biochemical mechanisms and therapeutic potential of pseudohalide thiocyanate in human health.
Biogenesis of Selenium Nanoparticles Using Green Chemistry.
Decreased selenoprotein expression alters the immune response during influenza virus infection in mice.
Differential expression profiles in the midgut of Triatoma infestans infected with Trypanosoma cruzi.
Histone Methyltransferase SET8 Epigenetically Reprograms Host Immune Responses to Assist Mycobacterial Survival.
Identification of a thioredoxin reductase from Babesia microti during mammalian infection.
Insights into the fish thioredoxin system: expression profile of thioredoxin and thioredoxin reductase in rainbow trout (Oncorhynchus mykiss) during infection and in vitro stimulation.
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.
The Essential Thioredoxin Reductase of the Human Pathogenic Mold Aspergillus fumigatus Is a Promising Antifungal Target.
The Redox Systems of Plasmodium falciparum and Plasmodium vivax: Comparison, In silico Analyses and Inhibitor Studies.
Thioredoxin reductase gene expression and activity among human T-cell lymphotropic virus type 1-infected patients.
Thioredoxin reductase inhibitors: updated patent review (2017-present).
Thioredoxin Reductase Is a Valid Target for Antimicrobial Therapeutic Development Against Gram-Positive Bacteria.
TrxR, a new CovR-repressed response regulator that activates the Mga virulence regulon in group A Streptococcus.
Insulin Resistance
GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity.
High-fat diet-induced changes in liver thioredoxin and thioredoxin reductase as a novel feature of insulin resistance.
miR?875?5p regulates IR and inflammation via targeting TXNRD1 in gestational diabetes rats.
Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness.
Insulinoma
Thioredoxin-mimetic peptides (TXM) reverse auranofin induced apoptosis and restore insulin secretion in insulinoma cells.
Iron Overload
Thalassemia major patients using iron chelators showed a reduced plasma thioredoxin level and reduced thioredoxin reductase activity, despite elevated oxidative stress.
Ischemic Attack, Transient
Comparison of the Immunoreactivity of Trx2/Prx3 Redox System in the Hippocampal CA1 Region Between the Young and Adult Gerbil Induced by Transient Cerebral Ischemia.
Kashin-Beck Disease
Patients with Osteoarthritis and Kashin-Beck Disease Display Distinct CpG Methylation Profiles in the DIO2, GPX3, and TXRND1 Promoter Regions.
The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease.
[TrxR2 gene polymorphisms may not be associated with the susceptibility to Kashin-Beck disease.]
Kidney Failure, Chronic
Differential expression of MAP3K7 and TROPONIN C proteins and related perturbations in renal amyloidosis.
Latent Infection
Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity.
Leprosy
Thioredoxin reductase as a pathophysiological factor and drug target.
Leukemia
A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells.
Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.
Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells.
Targeting thioredoxin reductase by plumbagin contributes to inducing apoptosis of HL-60 cells.
The selenoprotein thioredoxin reductase is expressed in peripheral blood monocytes and THP1 human myeloid leukemia cells--regulation by 1,25-dihydroxyvitamin D3 and selenite.
Thioredoxin reductase is a major regulator of metabolism in leukemia cells.
Thioredoxin reductase, a redox-active selenoprotein, is secreted by normal and neoplastic cells: presence in human plasma.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Inhibition of thioredoxin reductase by auranofin induces apoptosis in adriamycin-resistant human K562 chronic myeloid leukemia cells.
[Effect of Nrf2 and TrxR on proliferation of chronic myeloid leukemia cell and its mechanism].
Leukemia, Myeloid
The selenoprotein thioredoxin reductase is expressed in peripheral blood monocytes and THP1 human myeloid leukemia cells--regulation by 1,25-dihydroxyvitamin D3 and selenite.
Leukemia, Myeloid, Acute
Peperomin E and its orally bioavailable analog induce oxidative stress-mediated apoptosis of acute myeloid leukemia progenitor cells by targeting thioredoxin reductase.
The novel thioredoxin reductase inhibitor A-Z2 triggers intrinsic apoptosis and shows efficacy in the treatment of acute myeloid leukemia.
Leukemia, T-Cell
The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation.
Liver Cirrhosis
Therapeutic Effects of an Inhibitor of Thioredoxin Reductase on Liver Fibrosis by Inhibiting the Transforming Growth Factor-?1/Smads Pathway.
Liver Neoplasms
10H-3,6-Diazaphenothiazine-Induced, Caspases-Mediated Mitochondrial-Dependent Apoptosis on HepG2 Hepatocellular Carcinoma Cells and Suppressed Cancer Cells Invasion via Inhibiting Mitochondrial Thioredoxin Reductase Enzymatic Activities.
Clinical application of thioredoxin reductase as a novel biomarker in liver cancer.
Inhibiting TrxR suppresses liver cancer by inducing apoptosis and eliciting potent antitumor immunity.
TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.
Lung Diseases
Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition.
Lung Injury
Alleviation of lung injury by glycyrrhizic acid in benzo(a)pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase.
Effects of hyperoxia on cytoplasmic thioredoxin system in alveolar type epithelial cells of premature rats.
Pulmonary injury and antioxidant response in mice exposed to arsenate and hexavalent chromium and their combination.
Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition.
The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms.
The Thioredoxin Reductase-1 Inhibitor Aurothioglucose Attenuates Lung Injury and Improves Survival in a Murine Model of Acute Respiratory Distress Syndrome.
Thioredoxin Reductase Inhibition Attenuates Neonatal Hyperoxic Lung Injury and Enhances Nuclear Factor E2-Related Factor 2 Activation.
Thioredoxin reductase inhibition elicits nrf2-mediated responses in clara cells: implications for oxidant-induced lung injury.
Thioredoxin-related mechanisms in hyperoxic lung injury in mice.
Lung Neoplasms
Auranofin inhibits the proliferation of lung cancer cells via necrosis and caspase?dependent apoptosis.
Discovery of New Monocarbonyl Ligustrazine-Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer.
Dose-biomarker-response modeling of the anticancer effect of ethaselen in a human non-small cell lung cancer xenograft mouse model.
Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity. Effects on thioredoxin reductase and glutathione reductase.
Effects of redox modulation by inhibition of Thioredoxin reductase on radiosensitivity and gene expression.
Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo.
Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent.
Expression profiles of thioredoxin family proteins in human lung cancer tissue: correlation with proliferation and differentiation.
Inhibition of TrxR2 suppressed NSCLC cell proliferation, metabolism and induced cell apoptosis through decreasing antioxidant activity.
KEAP1-Dependent Synthetic Lethality Induced by AKT and TXNRD1 Inhibitors in Lung Cancer.
Long-term study of ovine pulmonary adenocarcinogenesis in sheep with marginal vs. sufficient nutritional selenium supply: Results from computed tomography, pathology, immunohistochemistry, JSRV-PCR and lung biochemistry.
Mammalian thioredoxin reductase alters cytolytic activity of an antibacterial peptide.
Menin?MLL inhibitors induce ferroptosis and enhance the anti?proliferative activity of auranofin in several types of cancer cells.
MicroRNA-124 regulates the radiosensitivity of non-small cell lung cancer cells by targeting TXNRD1.
microRNA-130b-3p Contained in MSC-Derived EVs Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis.
miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2.
Potential Anticancer Activity of Auranofin.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Selenium-containing thioredoxin reductase inhibitor ethaselen sensitizes non-small cell lung cancer to radiotherapy.
Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway.
Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells.
The serum activity of thioredoxin reductases 1 (TrxR1) is correlated with the poor prognosis in EGFR wild-type and ALK negative non-small cell lung cancer.
Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction.
Thioredoxin Reductase as a Novel and Efficient Plasma Biomarker for the Detection of Non-Small Cell Lung Cancer: a Large-scale, Multicenter study.
Treatment of lung cancer cells with cytotoxic levels of sodium selenite: effects on the thioredoxin system.
Lymphatic Metastasis
Is selenium a potential treatment for cancer metastasis?
Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.
[Expression of thioredoxin reductase 1 (TrxR1) in gastric cancer and its effect on the growth of gastric cancer cells].
Lymphoma
Investigating the Thioredoxin and Glutathione Systems' Response in Lymphoma Cells after Treatment with [Au(d2pype)2]CL.
Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates.
Lymphoma, B-Cell
Nitro aspirin (NCX4040) induces apoptosis in PC3 metastatic prostate cancer cells via hydrogen peroxide (H2O2)-mediated oxidative stress.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Malaria
Acid-base catalysis in the mechanism of thioredoxin reductase from Drosophila melanogaster.
Discovery and biochemical characterization of Plasmodium thioredoxin reductase inhibitors from an antimalarial set.
Identification of acid-base catalytic residues of high-Mr thioredoxin reductase from Plasmodium falciparum.
Identification of Oleamide in Guatteria recurvisepala by LC/MS-Based Plasmodium falciparum Thioredoxin Reductase Ligand Binding Method.
Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity.
Plasmodium falciparum Thioredoxin Reductase (PfTrxR) and Its Role as a Target for New Antimalarial Discovery.
Preliminary LC-MS Based Screening for Inhibitors of Plasmodium falciparum Thioredoxin Reductase (PfTrxR) among a Set of Antimalarials from the Malaria Box.
Synthesis of 5,5'-dithiobis(2-nitrobenzamides) as alternative substrates for trypanothione reductase and thioredoxin reductase: a microtiter colorimetric assay for inhibitor screening.
The 58 kDa mouse selenoprotein is a BCNU-sensitive thioredoxin reductase.
The malaria parasite Plasmodium falciparum possesses a functional thioredoxin system.
Thioredoxin reductase as a pathophysiological factor and drug target.
Thioredoxin reductase from the malaria mosquito Anopheles gambiae.
Thioredoxin, thioredoxin reductase, and thioredoxin peroxidase of malaria parasite Plasmodium falciparum.
Medulloblastoma
Thioredoxin System Protein Expression Is Associated with Poor Clinical Outcome in Adult and Paediatric Gliomas and Medulloblastomas.
Melanoma
A Diselenide Turn-On Fluorescent Probe for the Detection of Thioredoxin Reductase.
Accessing the transcriptional status of selenoproteins in skin cancer-derived cell lines.
Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells.
Calcium regulates thioredoxin reductase in human metastatic melanoma.
Calcium transport and regulation in human primary and metastatic melanoma.
Evaluation of N-acetyl-S-(p-chlorophenylcarbamoyl)cysteine as an irreversible inhibitor of mammalian thioredoxin reductase1.
Is selenium a potential treatment for cancer metastasis?
New aspects in the pathophysiology of cutaneous melanoma: a review of the role of thioproteins and the effect of nitrosoureas.
Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.
Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase.
Sensitivity and resistance in human metastatic melanoma to the new chloroethylnitrosourea anti-tumor drug Fotemustine.
The activity and purification of membrane-associated thioredoxin reductase from human metastatic melanotic melanoma.
The role of thioredoxin reductase 1 in melanoma metabolism and metastasis.
The stereospecific suicide inhibition of human melanoma thioredoxin reductase by 13-cis-retinoic acid.
Thioredoxin reductase activity at the surface of human primary cutaneous melanomas and their surrounding skin.
Thioredoxin reductase induction coincides with melanin biosynthesis in brown and black guinea pigs and in murine melanoma cells.
Thioredoxin reductase, a redox-active selenoprotein, is secreted by normal and neoplastic cells: presence in human plasma.
Thioredoxin, thioredoxin reductase and tumour necrosis factor-alpha expression in melanoma cells: correlation to resistance against cytotoxic attack.
Triphenylphosphonium derivatives disrupt metabolism and inhibit melanoma growth in vivo when delivered via a thermosensitive hydrogel.
Melanoma, Amelanotic
Calcium regulates thioredoxin reductase in human metastatic melanoma.
The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase.
Meningioma
High thioredoxin reductase 1 expression in meningiomas undergoing malignant progression.
Mercury Poisoning
Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning.
Mesothelioma
Auranofin induces mesothelioma cell death through oxidative stress and GSH depletion.
Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma.
Mesothelioma, Malignant
Quantification of alternative mRNA species and identification of thioredoxin reductase 1 isoforms in human tumor cells.
Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma.
Multiple Myeloma
Anticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma.
Cross-talk between two antioxidants, thioredoxin reductase and heme oxygenase-1, and therapeutic implications for multiple myeloma.
Mitochondrial thioredoxin reductase regulates major cytotoxicity pathways of proteasome inhibitors in multiple myeloma cells.
TrxR1 inhibition overcomes both hypoxia-induced and acquired bortezomib resistance in multiple myeloma through NF-?? inhibition.
Muscular Diseases
Why 21? The significance of selenoproteins for human health revealed by inborn errors of metabolism.
Myocardial Infarction
Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus.
Nasal Polyps
Expression and distribution of thioredoxin and thioredoxin reductase in human nasal mucosa and nasal polyp.
Nasopharyngeal Carcinoma
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Neoplasm Metastasis
Anti-recurrence/metastasis and chemosensitization therapy with thioredoxin reductase-interfering drug delivery system.
Auranofin improves overall survival when combined with standard of care in a pilot study involving dogs with osteosarcoma.
Auranofin is a potent suppressor of osteosarcoma metastasis.
Clinical application of thioredoxin reductase as a novel biomarker in liver cancer.
Efficacy of novel methylenecyclohexenone derivatives as TrxR inhibitors in suppressing the proliferation and metastasis of human cancer cells.
Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy.
Is selenium a potential treatment for cancer metastasis?
Mutational landscape and potential therapeutic targets for sporadic pancreatic neuroendocrine tumors based on target next-generation sequencing.
New aspects in the pathophysiology of cutaneous melanoma: a review of the role of thioproteins and the effect of nitrosoureas.
Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation.
The activity and purification of membrane-associated thioredoxin reductase from human metastatic melanotic melanoma.
The role of thioredoxin reductase 1 in melanoma metabolism and metastasis.
The thioredoxin system in breast cancer cell invasion and migration.
Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.
[Expression of thioredoxin reductase 1 (TrxR1) in gastric cancer and its effect on the growth of gastric cancer cells].
Neoplasms
10H-3,6-Diazaphenothiazine-Induced, Caspases-Mediated Mitochondrial-Dependent Apoptosis on HepG2 Hepatocellular Carcinoma Cells and Suppressed Cancer Cells Invasion via Inhibiting Mitochondrial Thioredoxin Reductase Enzymatic Activities.
2a, a novel curcumin analog, sensitizes cisplatin-resistant A549 cells to cisplatin by inhibiting thioredoxin reductase concomitant oxidative stress damage.
3-Nitro-2H-chromenes as a New Class of Inhibitors against Thioredoxin Reductase and Proliferation of Cancer Cells.
3D QSAR and pharmacophore study of curcuminoids and curcumin analogs: interaction with thioredoxin reductase.
A Comparison of the Inhibitory Effects of Anti-Cancer Drugs on Thioredoxin Reductase and Glutathione S-Transferase in Rat Liver.
A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis.
A Gold(I) Complex Containing an Oleanolic Acid Derivative as a Potential Anti-ovarian Cancer Agent via Inhibiting TrxR and Activating ROS-mediated ERS.
A new mechanism of action for the anticancer drug mitomycin C: mechanism-based inhibition of thioredoxin reductase.
A new rhodium(I) NHC complex inhibits TrxR: In vitro cytotoxicity and in vivo hepatocellular carcinoma suppression.
A novel organoselenium compound induces cell cycle arrest and apoptosis in prostate cancer cell lines.
A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells.
A pan-cancer study of selenoprotein genes as promising targets for cancer therapy.
A thioredoxin reductase inhibitor induces growth inhibition and apoptosis in five cultured human carcinoma cell lines.
Acetylation Regulates Thioredoxin Reductase Oligomerization and Activity.
Activation of TAp73 and inhibition of TrxR by Verteporfin for improved cancer therapy in TP53 mutant pancreatic tumors.
Adipocytokines, inflammatory, epigenetic instability & angiogenesis biomarkers in type 2 diabetic Egyptian women with breast cancer.
Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities.
Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a.
Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology.
Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase.
Annatto Constituent Cis-Bixin has Selective Anticancer Effects Mediated by Oxidative Stress and Associated with Inhibition of Thioredoxin and Thioredoxin Reductase.
Anti-recurrence/metastasis and chemosensitization therapy with thioredoxin reductase-interfering drug delivery system.
Anticancer and Antiangiogenic Iron(II) Complexes That Target Thioredoxin Reductase to Trigger Cancer Cell Apoptosis.
Antiglioma activity of 2,2':6',2"-terpyridineplatinum(II) complexes in a rat model-Effects on cellular redox metabolism.
Antioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell lines.
Antioxidant enzymes in oligodendroglial brain tumors: association with proliferation, apoptotic activity and survival.
Applying the designed multiple ligands approach to inhibit dihydrofolate reductase and thioredoxin reductase for anti-proliferative activity.
APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase.
Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase.
Augmented antitumor effects of combination therapy of cisplatin with ethaselen as a novel thioredoxin reductase inhibitor on human A549 cell in vivo.
Auranofin inhibits the proliferation of lung cancer cells via necrosis and caspase?dependent apoptosis.
Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species.
Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep3B cells by generation of reactive oxygen species.
Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties.
Bimetallic titanocene-gold phosphane complexes inhibit invasion, metastasis, and angiogenesis-associated signaling molecules in renal cancer.
Bioorthogonal Activation of Dual Catalytic and Anti-Cancer Activities of Organogold(I) Complexes in Living Systems.
Bis-anthracycline WP760 abrogates melanoma cell growth by transcription inhibition, p53 activation and IGF1R downregulation.
Butyltin(IV) benzoates: inhibition of thioredoxin reductase, tumor cell growth inhibition, and interactions with proteins.
Calcium transport and regulation in human primary and metastatic melanoma.
Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase.
Carbon Dot Based, Naphthalimide Coupled FRET Pair for Highly Selective Ratiometric Detection of Thioredoxin Reductase and Cancer Screening.
Carbon dots as analytical tools for sensing of thioredoxin reductase and screening of cancer cells.
Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells.
Cell line-directed screening assay for inhibitors of thioredoxin reductase signaling as potential anti-cancer drugs.
Certain (-)-epigallocatechin-3-gallate (EGCG) auto-oxidation products (EAOPs) retain the cytotoxic activities of EGCG.
Characterization of Hydrophilic Gold(I) N-Heterocyclic Carbene (NHC) Complexes as Potent TrxR Inhibitors Using Biochemical and Mass Spectrometric Approaches.
Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells.
Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention.
Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures.
Clinical application of thioredoxin reductase as a novel biomarker in liver cancer.
Clinical utility of antioxidant gene expression levels in circulating cancer cell clusters for the detection of prostate cancer in patients with prostate-specific antigen levels of 4-10 ng/mL and disease prognostication after radical prostatectomy.
Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer.
Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity.
Compensatory combination of mTOR and TrxR inhibitors to cause oxidative stress and regression of tumors.
Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells.
Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer.
Cross-talk between Bcr-abl and the Thioredoxin System in Chronic Myeloid Leukaemia: Implications for CML Treatment.
Crossroads of Cancer and HIV-1: Pathways to a Cure for HIV.
Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism.
Curcuminoid WZ35 synergize with cisplatin by inducing ROS production and inhibiting TrxR1 activity in gastric cancer cells.
Current Progresses in Metal-based Anticancer Complexes as Mammalian TrxR Inhibitors.
CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide.
Cyclodextrin-derived diorganyl tellurides as glutathione peroxidase mimics and inhibitors of thioredoxin reductase and cancer cell growth.
Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo.
Cyclophosphamide-evoked heart failure involves pronounced co-suppression of cytoplasmic thioredoxin reductase activity and non-protein free thiol level.
D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H2O2-mediated oxidative stress.
Decreased expression of antioxidant enzymes is associated with aggressive features in ependymomas.
Design and SAR of Withangulatin A Analogues that Act as Covalent TrxR Inhibitors through the Michael Addition Reaction Showing Potential in Cancer Treatment.
Design, synthesis and bioactivity evaluation of coumarin-chalcone hybrids as potential anticancer agents.
Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor.
Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents.
Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase.
Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols.
DIAPH3 promotes pancreatic cancer progression by activating selenoprotein TrxR1-mediated antioxidant effects.
Diasteltoxins A-C, Asteltoxin-Based Dimers from a Mutant of the Sponge-Associated Emericella variecolor Fungus.
Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy.
Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: Possible involvement of ROS and thioredoxin reductase.
Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma.
Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition.
Discovery of New Monocarbonyl Ligustrazine-Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer.
Disruption of redox homeostasis in the transforming growth factor-alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.
Diterpenoids with thioredoxin reductase inhibitory activities from Jatropha multifida.
Dose-biomarker-response modeling of the anticancer effect of ethaselen in a human non-small cell lung cancer xenograft mouse model.
Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells.
Dual targeting of the cancer antioxidant network with 1,4-naphthoquinone fused Gold(i) N-heterocyclic carbene complexes.
Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: A novel synergistic therapeutic approach.
EF24 induces ROS-mediated apoptosis via targeting thioredoxin reductase 1 in gastric cancer cells.
Effect of selenium on expression of selenoproteins in mouse fibrosarcoma cells.
Effects of Mammalian Thioredoxin Reductase Inhibitors.
Effects of the antioxidant Pycnogenol on cellular redox systems in U1285 human lung carcinoma cells.
Efficacy of novel methylenecyclohexenone derivatives as TrxR inhibitors in suppressing the proliferation and metastasis of human cancer cells.
Enhanced targeting of mitochondrial peroxide defense by the combined use of thiosemicarbazones and inhibitors of thioredoxin reductase.
Enhancement of auranofin-induced apoptosis in MCF-7 human breast cells by selenocystine, a synergistic inhibitor of thioredoxin reductase.
Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo.
Enzyme-mediated depletion of l-cyst(e)ine synergizes with thioredoxin reductase inhibition for suppression of pancreatic tumor growth.
Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention.
Ethaselen synergizes with oxaliplatin in tumor growth inhibition by inducing ROS production and inhibiting TrxR1 activity in gastric cancer.
Ethaselen: a novel organoselenium anticancer agent targeting thioredoxin reductase 1 reverses cisplatin resistance in drug-resistant K562 cells by inducing apoptosis.
Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent.
Expression of antioxidant enzymes in astrocytic brain tumors.
Expression of Antioxidant Molecules and Heat Shock Protein 27 in Thyroid Tumors.
Expression of reactive oxygen species-related proteins according to androgen and HER-2 status in estrogen receptor-negative breast cancer.
Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer.
Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer.
From Catalysis to Cancer: Toward Structure-Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents.
Further exploration of DVD-445 as a lead thioredoxin reductase (TrxR) inhibitor for cancer therapy: Optimization of potency and evaluation of anticancer potential.
Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase.
Gene expression analysis on the dicyclanil-induced hepatocellular tumors in mice.
Glutathione reductase (GSR) gene deletion and chromosome 8 aneuploidy in primary lung cancers detected by fluorescence in situ hybridization.
Gold(I) carbene complexes causing thioredoxin 1 and thioredoxin 2 oxidation as potential anticancer agents.
Gold(I) complex of N,N'-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties-potent tight-binding inhibition of thioredoxin reductase.
Gold(I) complexes with thiosemicarbazones: cytotoxicity against human tumor cell lines and inhibition of thioredoxin reductase activity.
High Density of NRF2 Expression in Malignant Cells Is Associated with Increased Risk of CNS Metastasis in Early-Stage NSCLC.
High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs.
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin ?-2 Expression, and Induce Antitumor Effects against Human Glioma.
Hypoxia-Sensitive Metal ?-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis.
Identification and targeting of selective vulnerability rendered by tamoxifen resistance.
Identification of phenazine analogue as a novel scaffold for thioredoxin reductase I inhibitors against Hep G2 cancer cell lines.
Impact of trivalent arsenicals on selenoprotein synthesis.
In vitro antineoplastic effects of auranofin in canine lymphoma cells.
Increased levels of cytosolic thioredoxin reductase activity and mRNA in rat liver nodules.
Induction of Oxidative Stress via Inhibition of Thioredoxin Reductase 1 is an Effective Therapeutic Approach for Hepatocellular Carcinoma.
Induction of thioredoxin, thioredoxin reductase and glutaredoxin activity in mouse skin by TPA, a calcium ionophore and other tumor promoters.
Inhibition of Both Thioredoxin Reductase and Glutathione Reductase may Contribute to the Anticancer Mechanism of TH-302.
Inhibition of glutathione synthesis eliminates the adaptive response of ascitic hepatoma 22 cells to nedaplatin that targets thioredoxin reductase.
Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity.
Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy.
Inhibition of thioredoxin reductase by alantolactone prompts oxidative stress-mediated apoptosis of HeLa cells.
Inhibition of thioredoxin reductase by auranofin induces apoptosis in adriamycin-resistant human K562 chronic myeloid leukemia cells.
Inhibition of thioredoxin reductase by mansonone F analogues: Implications for anticancer activity.
Inhibition of Thioredoxin Reductase by Santamarine Conferring Anticancer Effect in HeLa Cells.
Inhibition of Thioredoxin Reductase by Targeted Selenopolymeric Nanocarriers Synergizes the Therapeutic Efficacy of Doxorubicin in MCF7 Human Breast Cancer Cells.
Inhibition of Thioredoxin Reductase by Triosmium Carbonyl Clusters.
Inhibition of TrxR2 suppressed NSCLC cell proliferation, metabolism and induced cell apoptosis through decreasing antioxidant activity.
Inhibitory effect of green tea extract and (-)-epigallocatechin-3-gallate on mammalian thioredoxin reductase and HeLa cell viability.
Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance.
Interactions of nitroaromatic compounds with the Mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells.
Investigating the Thioredoxin and Glutathione Systems' Response in Lymphoma Cells after Treatment with [Au(d2pype)2]CL.
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.
Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death.
Is selenium a potential treatment for cancer metastasis?
Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells.
Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis.
Lichen acids may be used as a potential drug for cancer therapy; by inhibiting mitochondrial thioredoxin reductase purified from rat lung.
Lichen Acids May Be Used as A Potential Drug For Cancer Therapy; by Inhibiting Mitochondrial Thioredoxin Reductase Purified From Rat Lung.
LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer.
Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation.
Luteolin and 5-flurouracil act synergistically to induce cellular weapons in experimentally induced Solid Ehrlich Carcinoma: Realistic role of P53; a guardian fights in a cellular battle.
Maintenance of S-nitrosothiol homeostasis plays an important role in growth suppression of estrogen receptor-positive breast tumors.
Making Aggregation-Induced Emission Luminogen More Valuable by Gold: Enhancing Anticancer Efficacy by Suppressing Thioredoxin Reductase Activity.
Mammalian thioredoxin reductase alters cytolytic activity of an antibacterial peptide.
MDA-7/IL-24 induces Bcl-2 denitrosylation and ubiquitin-degradation involved in cancer cell apoptosis.
Mechanisms of the regulation of thioredoxin reductase activity in cancer cells by the chemopreventive agent selenium.
Menin?MLL inhibitors induce ferroptosis and enhance the anti?proliferative activity of auranofin in several types of cancer cells.
Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase.
miR-125a-5p Functions as Tumor Suppressor microRNA And Is a Marker of Locoregional Recurrence And Poor prognosis in Head And Neck Cancer.
miR-125b-5p inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma via targeting TXNRD1.
Mitochondria-Targeted Approach: Remarkably Enhanced Cellular Bioactivities of TPP2a as Selective Inhibitor and Probe toward TrxR.
Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols.
Mitochondrial targeted curcumin exhibits anticancer effects through disruption of mitochondrial redox and modulation of TrxR2 activity.
Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State.
Mitochondrial TXNRD3 confers drug resistance via redox-mediated mechanism and is a potential therapeutic target in vivo.
Molecular bases of thioredoxin and thioredoxin reductase-mediated prooxidant actions of (-)-epigallocatechin-3-gallate.
Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase.
Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase.
Motexafin gadolinium: a novel redox active drug for cancer therapy.
Multifunctional AuI -based AIEgens: Manipulating Molecular Structures and Boosting Specific Cancer Cell Imaging and Theranostics.
Natural-Like Spirocyclic ??,? -Butenolides Obtained from Diazo Homophthalimides.
New lanostane-type triterpenoids from the fruiting body of Ganoderma hainanense.
Noble metal targeting of thioredoxin reductase - covalent complexes with thioredoxin and thioredoxin-related protein of 14kDa triggered by cisplatin.
Noncovalent Self-Assembled Smart Gold(III) Porphyrin Nanodrug for Synergistic Chemo-Photothermal Therapy.
Novel antitumor adamantane-azole gold(I) complexes as potential inhibitors of thioredoxin reductase.
Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy.
Novel mechanism of ethaselen in poorly differentiated colorectal RKO cell growth inhibition: Simultaneous regulation of TrxR transcription, expression and enzyme activity.
Novel thioredoxin reductase inhibitor butaselen inhibits tumorigenesis by down-regulating programmed death-ligand 1 expression.
Novel TrxR1 Inhibitors Show Potential for Glioma Treatment by Suppressing the Invasion and Sensitizing Glioma Cells to Chemotherapy.
On the biological properties of alkynyl phosphine gold(i) complexes.
On the potential of thioredoxin reductase inhibitors for cancer therapy.
Onopordopicrin from the new genus Shangwua as a novel thioredoxin reductase inhibitor to induce oxidative stress-mediated tumor cell apoptosis.
Organotin complexes containing carboxylate ligands with maleimide and naphthalimide derived partial structures: TrxR inhibition, cytotoxicity and activity in resistant cancer cells.
Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells.
Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma.
Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas.
Overexpression of thioredoxin reductase 1 regulates NF-kappa B activation.
Oxidation of structural cysteine residues in thioredoxin 1 by aromatic arsenicals enhances cancer cell cytotoxicity caused by the inhibition of thioredoxin reductase 1.
Oxidation of thioredoxin reductase in HeLa cells stimulated with tumor necrosis factor-alpha.
Oxidative damage and antioxidants in cervical cancer.
Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches.
p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA.
Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer.
Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice.
Piperlongumine Analogs Promote A549 Cell Apoptosis through Enhancing ROS Generation.
Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer.
Piperlongumine potentiates the antitumor efficacy of oxaliplatin through ROS induction in gastric cancer cells.
Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress.
Plasma activity of Thioredoxin Reductase as a Novel Biomarker in Gastric Cancer.
Potent Activity of Indolequinones against Human Pancreatic Cancer: Identification of Thioredoxin Reductase as a Potential Target.
Potent inhibition of gastric cancer cells by a natural compound via inhibiting TrxR1 activity and activating ROS-mediated p38 MAPK pathway.
Potential Anticancer Activity of Auranofin.
Protective effects of selenium nanoparticle-enriched Lactococcus lactis NZ9000 against enterotoxigenic Escherichia coli K88-induced intestinal barrier damage in mice.
Proteomic analysis identifies protein targets responsible for depsipeptide sensitivity in tumor cells.
Purification of thioredoxin reductase from the Novikoff rat tumor.
Quantification of alternative mRNA species and identification of thioredoxin reductase 1 isoforms in human tumor cells.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Recent advances in the development of thioredoxin reductase inhibitors as anticancer agents.
Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1.
Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping.
Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.
Redox regulation of protein kinase C by selenometabolites and selenoprotein thioredoxin reductase limits cancer prevention by selenium.
Refeeding with glucose rather than fructose elicits greater hepatic inflammatory gene expression in mice.
Restraining Cancer Cells by Dual-Metabolic Inhibitions with a Mitochondrion-Targeted Platinum(II) Complex.
Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer.
Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress.
Rollover Cyclometalation vs Nitrogen Coordination in Tetrapyridyl Anticancer Gold(III) Complexes: Effect on Protein Interaction and Toxicity.
ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.
ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin.
Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase.
Ruthenium(II) salicylate complexes inducing ROS-mediated apoptosis by targeting thioredoxin reductase.
Sanguinarine as a new chemical entity of thioredoxin reductase inhibitor to elicit oxidative stress and promote tumor cell apoptosis.
Selective activation of a prodrug by thioredoxin reductase providing a novel strategy to target cancer cells.
Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation.
Selenadiazole derivatives as potent thioredoxin reductase inhibitors that enhance the radiosensitivity of cancer cells.
Selenadiazole derivatives as theranostic agents for simultaneous cancer chemo-/radiotherapy by targeting thioredoxin reductase.
Selenium and selenoproteins in the treatment and diagnostics of cancer.
Selenium compounds and selenoproteins in cancer.
Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase.
Selenoproteins and human health: Insights from epidemiological data.
Selenoproteins in bladder cancer.
Selenoproteins that function in cancer prevention and promotion.
Self-delivery nanomedicine for chemotherapy sensitized photodynamic therapy.
Sensitivity and resistance in human metastatic melanoma to the new chloroethylnitrosourea anti-tumor drug Fotemustine.
Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.
Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells.
SIGNIFICANCE OF THE MITOCHONDRIAL THIOREDOXIN REDUCTASE IN CANCER CELLS: AN UPDATE ON ROLE, TARGETS AND INHIBITORS.
SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC.
Small molecules targeting the selenoprotein thioredoxin reductase.
Smart mitochondrial-targeted cancer therapy: Subcellular distribution, selective TrxR2 inhibition accompany with declined antioxidant capacity.
Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents.
Spectroscopic and electrochemical characterization of gold(I) and gold(III) complexes with glyoxaldehyde bis(thiosemicarbazones): cytotoxicity against human tumor cell lines and inhibition of thioredoxin reductase activity.
Statins inhibit expression of thioredoxin reductase 1 in rat and human liver and reduce tumour development.
Sublethal concentrations of diverse gold compounds inhibit mammalian cytosolic thioredoxin reductase (TrxR1).
Susceptibility of the antioxidant selenoenzymes thioredoxin reductase and glutathione peroxidase to alkylation-mediated inhibition by anticancer acylfulvenes.
Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells.
Synergy between sulforaphane and selenium in protection against oxidative damage in colonic CCD841 cells.
Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors.
Synthesis and molecular recognition studies on small-molecule inhibitors for thioredoxin reductase.
Synthesis of 5,5'-dithiobis(2-nitrobenzamides) as alternative substrates for trypanothione reductase and thioredoxin reductase: a microtiter colorimetric assay for inhibitor screening.
Synthesis of 5-nitro-2-furancarbohydrazides and their cis-diamminedichloroplatinum complexes as bitopic and irreversible human thioredoxin reductase inhibitors.
Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent.
Synthesis, SAR and biological evaluation of a novel series of 1-(2-chloroethyl)-1-nitroso-3-(2-(3-oxobenzoelenazol-2(3H)-yl)ethyl) urea: Organoselenium compounds for cancer therapy.
Targeting selenium metabolism and selenoproteins: novel avenues for drug discovery.
Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy.
Targeting the Thioredoxin System as a Strategy for Cancer Therapy.
Targeting the Thioredoxin System for Cancer Therapy.
Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication.
Targeting thioredoxin reductase by deoxyelephantopin from Elephantopus scaber triggers cancer cell apoptosis.
Targeting thioredoxin reductase by plumbagin contributes to inducing apoptosis of HL-60 cells.
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide.
Targeting Thioredoxin Reductase: Anticancer Agents and Chemopreventive Compounds.
The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways.
The 58 kDa mouse selenoprotein is a BCNU-sensitive thioredoxin reductase.
The Antagonistic Effect of Selenium on Cadmium-Induced Damage and mRNA Levels of Selenoprotein Genes and Inflammatory Factors in Chicken Kidney Tissue.
The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation.
The antimetastatic effect and underlying mechanisms of thioredoxin reductase inhibitor ethaselen.
The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity.
The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth.
The effect of sodium selenite on liver growth and thioredoxin reductase expression in regenerative and neoplastic liver cell proliferation.
The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage.
The mechanism of apoptosis induced by a novel thioredoxin reductase inhibitor in A549 cells: possible involvement of nuclear factor-kappaB-dependent pathway.
The novel SOD mimetic GC4419 increases cancer cell killing with sensitization to ionizing radiation while protecting normal cells.
The role of thioredoxin reductase and glutathione reductase in plumbagin-induced, reactive oxygen species-mediated apoptosis in cancer cell lines.
The role of thioredoxin system in cancer: strategy for cancer therapy.
The serum activity of thioredoxin reductases 1 (TrxR1) is correlated with the poor prognosis in EGFR wild-type and ALK negative non-small cell lung cancer.
The thioredoxin system and cancer therapy: a review.
The thioredoxin system in cancer.
The yin and yang of nrf2-regulated selenoproteins in carcinogenesis.
Thiol antioxidant thioredoxin reductase: A prospective biochemical crossroads between anticancer and antiparasitic treatments of the modern era.
Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy.
Thioredoxin and thioredoxin reductase expression in thyroid cancer depends on tumour aggressiveness.
Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.
Thioredoxin and thioredoxin reductase: current research with special reference to human disease.
Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation.
Thioredoxin is associated with proliferation, p53 expression and negative estrogen and progesterone receptor status in breast carcinoma.
Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism.
Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells.
Thioredoxin reductase 1 is upregulated in atherosclerotic plaques: specific induction of the promoter in human macrophages by oxidized low-density lipoproteins.
Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis.
Thioredoxin Reductase Activity Predicts Gold Nanoparticle Radiosensitization Effect.
Thioredoxin reductase and cancer cell growth inhibition by organogold(III) compounds.
Thioredoxin reductase and cancer cell growth inhibition by organotellurium antioxidants.
Thioredoxin reductase and cancer cell growth inhibition by organotellurium compounds that could be selectively incorporated into tumor cells.
Thioredoxin Reductase as a Novel and Efficient Plasma Biomarker for the Detection of Non-Small Cell Lung Cancer: a Large-scale, Multicenter study.
Thioredoxin reductase as a novel molecular target for cancer therapy.
Thioredoxin reductase as a pathophysiological factor and drug target.
Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy.
Thioredoxin reductase inhibition by antitumor quinols: a quinol pharmacophore effect correlating to antiproliferative activity.
Thioredoxin Reductase Inhibition for Cancer Therapy.
Thioredoxin reductase inhibitors: a patent review.
Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity.
Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles.
Thioredoxin reductase regulates angiogenesis by increasing endothelial cell-derived vascular endothelial growth factor.
Thioredoxin reductase, a redox-active selenoprotein, is secreted by normal and neoplastic cells: presence in human plasma.
Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells.
Thioredoxin reductase.
Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy.
Thioredoxin, glutathione and related molecules in tumors of the nervous system.
Thioredoxin, thioredoxin reductase and tumour necrosis factor-alpha expression in melanoma cells: correlation to resistance against cytotoxic attack.
Thioredoxin-dependent system. Application of inhibitors.
TIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport.
Tissue and Plasma Thioredoxin Reductase Expressions in Patients with Glioblastoma Multiforme.
Tissue thioredoxin reductase-1 expression in astrocytomas of different grades.
Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2.
Transcriptomic analysis of the effect of ifosfamide on MDCK cells cultivated in microfluidic biochips.
Treatment of lung cancer cells with cytotoxic levels of sodium selenite: effects on the thioredoxin system.
TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.
TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin.
TXNRD1 Is an Unfavorable Prognostic Factor for Patients with Hepatocellular Carcinoma.
Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma.
Upregulation of the thioredoxin-dependent redox system during differentiation of 3T3-L1 cells to adipocytes.
Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.
Virtual screening-guided discovery of thioredoxin reductase inhibitors.
Water-soluble organotellurium compounds inhibit thioredoxin reductase and the growth of human cancer cells.
Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma.
Xanthatin Promotes Apoptosis via Inhibiting Thioredoxin Reductase and Eliciting Oxidative Stress.
[Correlation of plasma thioredoxin reductase activity to growth of H22 hepatocellular carcinoma xenografts in Kunming mice.]
[Potential Anticancer Activity of Auranofin].
[Selenoprotein thioredoxin reductase mediated menadione reduction: catalytic properties & inhibition effects].
[Thioredoxin reductase--a new target for molecular medical investigations]
Nervous System Diseases
Protection against reactive oxygen species by selenoproteins.
Thioredoxin reductase 1 haplotypes modify familial amyotrophic lateral sclerosis onset.
Neuroblastoma
Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols.
Diphenyl diselenide protects against methylmercury-induced inhibition of thioredoxin reductase and glutathione peroxidase in human neuroblastoma cells: a comparison with ebselen.
Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury.
Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway.
Thioredoxin alters the matrix metalloproteinase/tissue inhibitors of metalloproteinase balance and stimulates human SK-N-SH neuroblastoma cell invasion.
Toxicological effects of thiomersal and ethylmercury: Inhibition of the thioredoxin system and NADP(+)-dependent dehydrogenases of the pentose phosphate pathway.
Neurocysticercosis
Purification and kinetic analysis of cytosolic and mitochondrial thioredoxin glutathione reductase extracted from Taenia solium cysticerci.
Neurodegenerative Diseases
The role of thioredoxin reductases in brain development.
Neuroectodermal Tumors, Primitive
Mutational landscape and potential therapeutic targets for sporadic pancreatic neuroendocrine tumors based on target next-generation sequencing.
Neuroinflammatory Diseases
Altered Expression of Peroxiredoxins in Mouse Model of Progressive Myoclonus Epilepsy upon LPS-Induced Neuroinflammation.
Selol, an organic selenium donor, prevents lipopolysaccharide-induced oxidative stress and inflammatory reaction in the rat brain.
Nevi and Melanomas
The role of thioredoxin reductase 1 in melanoma metabolism and metastasis.
Nevus
A Phase II Randomized Placebo-Controlled Trial of Oral N-acetylcysteine for Protection of Melanocytic Nevi against UV-Induced Oxidative Stress In Vivo.
The role of thioredoxin reductase 1 in melanoma metabolism and metastasis.
Obesity
GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity.
Sexual dimorphism in the effect of maternal obesity on antioxidant defense mechanisms in the human placenta.
Osteoarthritis
Patients with Osteoarthritis and Kashin-Beck Disease Display Distinct CpG Methylation Profiles in the DIO2, GPX3, and TXRND1 Promoter Regions.
Osteoporosis
A microarray based identification of osteoporosis-related genes in primary culture of human osteoblasts.
Osteosarcoma
Auranofin improves overall survival when combined with standard of care in a pilot study involving dogs with osteosarcoma.
Ototoxicity
Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures.
Ovarian Neoplasms
A panel of three oxidative stress-related genes predicts overall survival in ovarian cancer patients received platinum-based chemotherapy.
Antiproliferative Homoleptic and Heteroleptic Phosphino Silver(I) Complexes: Effect of Ligand Combination on Their Biological Mechanism of Action.
Autoantibody to thioredoxin reductase in an ovarian cancer patient.
Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase.
Induction of apoptosis on ovarian adenocarcinoma cells, A2780 by tricyclohexylphosphanegold (I) mercaptobenzoate derivatives via intrinsic and extrinsic pathways.
Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells.
Novel insights into the synergistic interaction of a thioredoxin reductase inhibitor and TRAIL: the activation of the ASK1-ERK-Sp1 pathway.
Restraining Cancer Cells by Dual-Metabolic Inhibitions with a Mitochondrion-Targeted Platinum(II) Complex.
Pancreatic Neoplasms
A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells.
Antitumor Indolequinones Induced Apoptosis in Human Pancreatic Cancer Cells via Inhibition of Thioredoxin Reductase and Activation of Redox Signaling.
Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity.
Cytotoxic and radiosensitising effects of a novel thioredoxin reductase inhibitor in breast cancer.
Potent Activity of Indolequinones against Human Pancreatic Cancer: Identification of Thioredoxin Reductase as a Potential Target.
[Drug resistance and activity changes of thioredoxin reductase in pancreatic cancer cells strain SW1990 induced by gemcitabine]
Paralysis
Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins.
Parasitic Diseases
A review on the druggability of a thiol-based enzymatic antioxidant thioredoxin reductase for treating filariasis and other parasitic infections.
Purification and kinetic analysis of cytosolic and mitochondrial thioredoxin glutathione reductase extracted from Taenia solium cysticerci.
The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation.
Thioredoxin reductase as a pathophysiological factor and drug target.
Parkinson Disease
A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model.
Downregulation of thioredoxin reductase 1 expression in the substantia nigra pars compacta of Parkinson's disease mice.
Overexpression of thioredoxin reductase 1 can reduce DNA damage, mitochondrial autophagy and endoplasmic reticulum stress in Parkinson's disease.
Protective effect of thioredoxin reductase 1 in Parkinson's disease.
Perinatal Death
Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium.
Pigmentation Disorders
Free radical reduction in the human epidermis.
Pneumocystis Infections
Characterization of thioredoxin reductase genes (trr1) from Pneumocystis carinii and Pneumocystis jiroveci.
Pre-Eclampsia
Correlation of thioredoxin reductase (TrxR) and nitric oxide synthase (NOS) activities with serum trace elements in preeclampsia.
Placental oxidative stress, selenium and preeclampsia.
Selenoproteins and human health: Insights from epidemiological data.
Prostatic Hyperplasia
Stromal response to prostate cancer: nanotechnology-based detection of thioredoxin-interacting protein partners distinguishes prostate cancer associated stroma from that of benign prostatic hyperplasia.
Prostatic Neoplasms
A novel organoselenium compound induces cell cycle arrest and apoptosis in prostate cancer cell lines.
Antitumor activity of gold(III)-dithiocarbamato derivatives on prostate cancer cells and xenografts.
Expression of redox pathway enzymes in human prostatic tissue.
Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells.
Hemolysate thioredoxin reductase and glutathione peroxidase activities correlate with serum selenium in a group of New Zealand men at high prostate cancer risk.
In-vitro and in-vivo investigations into the carbene-gold anticancer drug candidates NHC*-Au-SCSNMe2 and NHC*-Au-S-GLUC against advanced prostate cancer PC3.
Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells.
Oxidative stress measured by thioredoxin reductase level as potential biomarker for prostate cancer.
Polymorphisms in thioredoxin reductase and selenoprotein K genes and selenium status modulate risk of prostate cancer.
Potent In Vitro and In Vivo Anticancer Activity of New Bipyridine and Bipyrimidine Gold (III) Dithiocarbamate Derivatives.
Preparation of Titanocene-Gold Compounds Based on Highly Active Gold(I)-N-Heterocyclic Carbene Anticancer Agents: Preliminary in?vitro Studies in Renal and Prostate Cancer Cell Lines.
Selenium- or Vitamin E-Related Gene Variants, Interaction with Supplementation, and Risk of High-Grade Prostate Cancer in SELECT.
Selenoprotein and antioxidant genes and the risk of high-grade prostate cancer and prostate cancer recurrence.
Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.
Stromal response to prostate cancer: nanotechnology-based detection of thioredoxin-interacting protein partners distinguishes prostate cancer associated stroma from that of benign prostatic hyperplasia.
Thioredoxin Reductase 1 Expression and Castration-recurrent Growth of Prostate Cancer.
Titanocene-Gold Complexes Containing N-Heterocyclic Carbene Ligands Inhibit Growth of Prostate, Renal, and Colon Cancers in Vitro.
Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer.
Protoporphyria, Erythropoietic
Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay.
Psoriasis
Anthralin inhibits elevated levels of thioredoxin reductase in psoriasis. A new mode of action for this drug.
Synthesis of 5,5'-dithiobis(2-nitrobenzamides) as alternative substrates for trypanothione reductase and thioredoxin reductase: a microtiter colorimetric assay for inhibitor screening.
The Relationship between Tissue Thioredoxin Reductase Activity and the Psoriasis Area and Severity Index.
Pulmonary Disease, Chronic Obstructive
Associations of the NRF2/KEAP1 pathway and antioxidant defense gene polymorphisms with chronic obstructive pulmonary disease.
Pulmonary Fibrosis
Inhibitory effects of thalidomide on bleomycin-induced pulmonary fibrosis in rats via regulation of thioredoxin reductase and inflammations.
Radiation Fibrosis Syndrome
SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling.
Renal Insufficiency, Chronic
Differential expression of MAP3K7 and TROPONIN C proteins and related perturbations in renal amyloidosis.
Reperfusion Injury
Effects of intermittent hypoxia on oxidative stress-induced myocardial damage in mice.
Myocardial ischemia-reperfusion injury, antioxidant enzyme systems, and selenium: a review.
Respiratory Distress Syndrome
The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms.
The Thioredoxin Reductase-1 Inhibitor Aurothioglucose Attenuates Lung Injury and Improves Survival in a Murine Model of Acute Respiratory Distress Syndrome.
Respiratory Insufficiency
Why 21? The significance of selenoproteins for human health revealed by inborn errors of metabolism.
Retinal Degeneration
Delay of photoreceptor degeneration in tubby mouse by sulforaphane.
Rhabdomyosarcoma, Alveolar
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Sarcoma
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Seizures
Up-regulation of antioxidative proteins TRX1, TXNL1 and TXNRD1 in the cortex of PTZ kindling seizure model mice.
Sepsis
Oxidant and antioxidant status in neonatal proven and clinical sepsis according to selenium status.
Small Cell Lung Carcinoma
Mammalian thioredoxin reductase alters cytolytic activity of an antibacterial peptide.
Squamous Cell Carcinoma of Head and Neck
Is selenium a potential treatment for cancer metastasis?
Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma.
PARP-1 inhibitors sensitize HNSCC cells to APR-246 by inactivation of thioredoxin reductase 1 (TrxR1) and promotion of ROS accumulation.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
The chemopreventive and clinically used agent curcumin sensitizes HPV (-) but not HPV (+) HNSCC to ionizing radiation, in vitro and in a mouse orthotopic model.
The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo.
Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.
Starvation
Immunohistochemical localization of thioredoxin and thioredoxin reductase in mouse exocrine and endocrine pancreas.
Upregulation of stress response genes and ABC transporters in anaerobic stationary-phase Mycobacterium smegmatis.
Stomach Neoplasms
A thioredoxin reductase inhibitor ethaselen induces growth inhibition and apoptosis in gastric cancer.
Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a.
Author Correction: Plasma activity of Thioredoxin Reductase as a Novel Biomarker in Gastric Cancer.
Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells.
Curcuminoid WZ35 synergize with cisplatin by inducing ROS production and inhibiting TrxR1 activity in gastric cancer cells.
EF24 induces ROS-mediated apoptosis via targeting thioredoxin reductase 1 in gastric cancer cells.
Ethaselen synergizes with oxaliplatin in tumor growth inhibition by inducing ROS production and inhibiting TrxR1 activity in gastric cancer.
Novel curcumin analogue hybrids: Synthesis and anticancer activity.
Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer.
Piperlongumine potentiates the antitumor efficacy of oxaliplatin through ROS induction in gastric cancer cells.
Plasma activity of Thioredoxin Reductase as a Novel Biomarker in Gastric Cancer.
Potent inhibition of gastric cancer cells by a natural compound via inhibiting TrxR1 activity and activating ROS-mediated p38 MAPK pathway.
Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation.
[Association of genetic polymorphisms in selenoprotein GPX1 and TXNRD2 with genetic susceptibility of gastric cancer]
[Expression of thioredoxin reductase 1 (TrxR1) in gastric cancer and its effect on the growth of gastric cancer cells].
Stroke
Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe.
thioredoxin-disulfide reductase deficiency
Enhancement of the efficacy of mitomycin C-mediated apoptosis in human colon cancer cells with RNAi-based thioredoxin reductase 1 deficiency.
Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1.
Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation.
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.
Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells.
Roles of thioredoxin reductase during the aerobic life of Lactococcus lactis.
Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism.
Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells.
Thioredoxin reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD).
Thioredoxin reductase deficiency potentiates oxidative stress, mitochondrial dysfunction and cell death in dopaminergic cells.
TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species.
Thyroid Neoplasms
A possible role for selenoprotein glutathione peroxidase (GPx1) and thioredoxin reductases (TrxR1) in thyroid cancer: our experience in thyroid surgery.
Thioredoxin and thioredoxin reductase expression in thyroid cancer depends on tumour aggressiveness.
Tongue Neoplasms
The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo.
Tremor
The role of thioredoxin reductases in brain development.
Triple Negative Breast Neoplasms
Alantolactone promotes ER stress-mediated apoptosis by inhibition of TrxR1 in triple-negative breast cancer cell lines and in a mouse model.
Cytotoxic and radiosensitising effects of a novel thioredoxin reductase inhibitor in breast cancer.
Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancer.
Tuberculosis
Cloning, expression and significance of MPT53 for identification of secreted proteins of Mycobacterium tuberculosis.
Conformational flexibility of Mycobacterium tuberculosis thioredoxin reductase: crystal structure and normal-mode analysis.
Docking into Mycobacterium tuberculosis Thioredoxin Reductase Protein Yields Pyrazolone Lead Molecules for Methicillin-Resistant Staphylococcus aureus.
Ebselen and analogs as inhibitors of Bacillus anthracis thioredoxin reductase and bactericidal antibacterials targeting Bacillus species, Staphylococcus aureus and Mycobacterium tuberculosis.
Expression, purification, crystallization and preliminary X-ray crystallographic studies of Mycobacterium tuberculosis thioredoxin reductase.
Glutathione disulfide and S-nitrosoglutathione detoxification by Mycobacterium tuberculosis thioredoxin system.
Histone Methyltransferase SET8 Epigenetically Reprograms Host Immune Responses to Assist Mycobacterial Survival.
Identification of M. tuberculosis thioredoxin reductase inhibitors based on high-throughput docking using constraints.
Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis.
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.
NrdH-redoxin of Mycobacterium tuberculosis and Corynebacterium glutamicum Dimerizes at High Protein Concentration and Exclusively Receives Electrons from Thioredoxin Reductase.
Reduction of peroxides and dinitrobenzenes by Mycobacterium tuberculosis thioredoxin and thioredoxin reductase.
Solution structures of Mycobacterium tuberculosis thioredoxin C and models of intact thioredoxin system suggest new approaches to inhibitor and drug design.
Structure-based identification of natural compound inhibitor against M. tuberculosis thioredoxin reductase: insight from molecular docking and dynamics simulation.
The crystal structure of Mycobacterium tuberculosis NrdH at 0.87 Å suggests a possible mode of its activity.
Upregulation of stress response genes and ABC transporters in anaerobic stationary-phase Mycobacterium smegmatis.
Tuberous Sclerosis
Activated p53 in the anti-apoptotic milieu of tuberous sclerosis gene mutation induced diseases leads to cell death if thioredoxin reductase is inhibited.
Urinary Bladder Neoplasms
p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells.
Selenoproteins in bladder cancer.
Uterine Cervical Neoplasms
B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy.
EM23, a natural sesquiterpene lactone, targets thioredoxin reductase to activate JNK and cell death pathways in human cervical cancer cells.
Novel triazolium based 11(th) group NHCs: synthesis, characterization and cellular response mechanisms.
Potent and selective cytotoxic and anti-inflammatory gold(III) compounds containing cyclometallated phosphine sulfide ligands.
Varicocele
Is thioredoxin reductase involved in the defense against DNA fragmentation in varicocele?
Vascular Diseases
Induction of Thioredoxin Reductase 1 by Korean Red Ginseng Water Extract Regulates Cytoprotective Effects on Human Endothelial Cells.
Vitiligo
Defective calcium uptake in keratinocyte cell cultures from vitiliginous skin.
In vivo and in vitro evidence for epidermal HO-mediated oxidative stress in piebaldism.
Increased epidermal functioning wild-type p53 expression in vitiligo.
Vitiligo at the site of radiotherapy for nasopharyngeal carcinoma.
Xeroderma Pigmentosum
Defects in antioxidant defense and calcium transport in the epidermis of xeroderma pigmentosum patients.