Any feedback?
Information on EC 1.8.1.9 - thioredoxin-disulfide reductase
for references in articles please use BRENDA:EC1.8.1.9Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.8.1.9 thioredoxin-disulfide reductaseIUBMB Comments
A flavoprotein (FAD).
Specify your search results
Word Map
- 1.8.1.9
- selenium
-
selenoproteins
- selenocysteine
- gsh
- peroxiredoxins
- dismutase
- catalase
- auranofin
- glutaredoxins
- trx1
-
selenoenzyme
- hydroperoxide
- peroxidases
- fad
- ribonucleotide
-
redox-active
- cisplatin
- dithiols
-
goldi
-
se-deficient
- dtnb
-
iodothyronine
-
flavoenzyme
- ebselen
-
redox-sensitive
-
selenium-containing
-
selenols
-
deiodinases
-
thiol-dependent
-
organoselenium
-
thioredoxin-like
-
selenium-deficient
-
se-dependent
-
n-heterocyclic
-
thioredoxin-dependent
- diselenide
-
redox-regulated
-
selenium-dependent
-
thiol-disulfide
-
thiol-based
- thioredoxin-1
- ask1
-
carbene
- 1-chloro-2,4-dinitrobenzene
- sulforaphane
-
secis
-
txnip
- trypanothione
- medicine
- analysis
- na2seo3
- agriculture
-
thioredoxin-interacting
The enzyme appears in viruses and cellular organisms
Synonyms
thioredoxin reductase, trxr, trxr1, txnrd1, thioredoxin reductase 1, trxr2, txnrd2, thioredoxin reductase-1, thioredoxin reductase 2, nadph-dependent thioredoxin reductase, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
general stress protein 35
-
-
-
-
GSP35
-
-
-
-
NADP-thioredoxin reductase
-
-
-
-
NADPH-thioredoxin reductase
-
-
-
-
NADPH2:oxidized thioredoxin oxidoreductase
-
-
-
-
reductase, thioredoxin
-
-
-
-
thioredoxin reductase (NADPH)
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
thioredoxin:NADP+ oxidoreductase
A flavoprotein (FAD).
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9074-14-0
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
C-terminal tetrapeptide sequences is Gly-Cys-Sec-Gly. Changing the C-terminal carboxylate of mTR3 to a carboxamide increases the activity of the enzyme. If the selenium content is normalized for both samples, the carboxamide mutant has nearly twice the activity as the semisynthetic wild-type carboxylate enzyme
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
C-terminal tetrapeptide sequences is Gly-Cys-Sec-Gly. Changing the C-terminal carboxylate of mTR3 to a carboxamide increases the activity of the enzyme. If the selenium content is normalized for both samples, the carboxamide mutant has nearly twice the activity as the semisynthetic wild-type carboxylate enzyme
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
DmTR shows high catalytic activity without the presence of a selenocysteine
additional information
-
DmTR shows high catalytic activity without the presence of a selenocysteine
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Thioredoxin reductase as a pathophysiological factor and drug target.
Acute Kidney Injury
Ifosfamide induces acute renal failure via inhibition of the thioredoxin reductase activity.
Acute Lung Injury
Club Cell Heme Oxygenase-1 Deletion: Effects in Hyperoxia-Exposed Adult Mice.
Adenocarcinoma
Antineoplastic effects of auranofin in human pancreatic adenocarcinoma preclinical models.
Adenocarcinoma
Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades.
Adenocarcinoma
Expression profiles of thioredoxin family proteins in human lung cancer tissue: correlation with proliferation and differentiation.
Adenocarcinoma of Lung
A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity.
Adenocarcinoma of Lung
Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo.
Adenocarcinoma of Lung
Heparin-binding properties of selenium-containing thioredoxin reductase from HeLa cells and human lung adenocarcinoma cells.
Adenocarcinoma of Lung
High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy.
Adenocarcinoma of Lung
Production of functional human selenocysteine-containing KDRF/thioredoxin reductase in E. coli.
Adenoma
Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer.
Adenoma
Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma.
Alzheimer Disease
Decreased thioredoxin and increased thioredoxin reductase levels in Alzheimer's disease brain.
Amebiasis
Entamoeba histolytica: identification of thioredoxin-targeted proteins and analysis of serine acetyltransferase-1 as a prototype example.
Amebiasis
Formation of oxidised (OX) proteins in Entamoeba histolytica exposed to auranofin and consequences on the parasite virulence.
Amebiasis
In vitro antiamoebic activity evaluation and docking studies of metronidazole-triazole hybrids.
Amyloidosis
Differential expression of MAP3K7 and TROPONIN C proteins and related perturbations in renal amyloidosis.
Amyotrophic Lateral Sclerosis
Thioredoxin reductase 1 haplotypes modify familial amyotrophic lateral sclerosis onset.
Aortic Aneurysm, Abdominal
Associations and interactions between variants in selenoprotein genes, selenoprotein levels and the development of abdominal aortic aneurysm, peripheral arterial disease, and heart failure.
Arthritis
Auranofin, a thioredoxin reductase inhibitor, causes platelet death through calcium overload.
Arthritis, Rheumatoid
Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells.
Arthritis, Rheumatoid
Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer.
Arthritis, Rheumatoid
High redox thioredoxin but low thioredoxin reductase activities in the serum of patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Plasma and Synovial Fluid TrxR Levels are Correlated With Disease Risk and Severity in Patients With Rheumatoid Arthritis.
Arthritis, Rheumatoid
Thioredoxin reductase as a pathophysiological factor and drug target.
Aspergillosis
Antibody specific to thioredoxin reductase as a new biomarker for serodiagnosis of invasive aspergillosis in non-neutropenic patients.
Aspergillosis
Immunoproteomics based identification of thioredoxin reductase GliT and novel Aspergillus fumigatus antigens for serologic diagnosis of invasive aspergillosis.
Aspergillosis
The Essential Thioredoxin Reductase of the Human Pathogenic Mold Aspergillus fumigatus Is a Promising Antifungal Target.
Asthma
Increased anti-oxidant enzyme activity and biological oxidation in placentae of pregnancies complicated by maternal asthma.
Atherosclerosis
Selenium in the prevention of atherosclerosis and its underlying mechanisms.
Atherosclerosis
Thioredoxin reductase 1 upregulates MCP-1 release in human endothelial cells.
Autoimmune Diseases
Synthesis of 5,5'-dithiobis(2-nitrobenzamides) as alternative substrates for trypanothione reductase and thioredoxin reductase: a microtiter colorimetric assay for inhibitor screening.
beta-Thalassemia
Thalassemia major patients using iron chelators showed a reduced plasma thioredoxin level and reduced thioredoxin reductase activity, despite elevated oxidative stress.
Blister
Defects in antioxidant defense and calcium transport in the epidermis of xeroderma pigmentosum patients.
Brain Neoplasms
Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections.
Brain Neoplasms
Thioredoxin System Protein Expression Is Associated with Poor Clinical Outcome in Adult and Paediatric Gliomas and Medulloblastomas.
Brain Neoplasms
Thioredoxin, glutathione and related molecules in tumors of the nervous system.
Breast Neoplasms
2-Tellurium-bridged ?-cyclodextrin, a thioredoxin reductase inhibitor, sensitizes human breast cancer cells to TRAIL-induced apoptosis through DR5 induction and NF-?B suppression.
Breast Neoplasms
A gold(I) phosphine complex selectively induces apoptosis in breast cancer cells: implications for anticancer therapeutics targeted to mitochondria.
Breast Neoplasms
Adipocytokines, inflammatory, epigenetic instability & angiogenesis biomarkers in type 2 diabetic Egyptian women with breast cancer.
Breast Neoplasms
Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer.
Breast Neoplasms
Cytotoxic and radiosensitising effects of a novel thioredoxin reductase inhibitor in breast cancer.
Breast Neoplasms
Cytotoxic, chemosensitizing and radiosensitizing effects of curcumin based on thioredoxin system inhibition in breast cancer cells: 2D vs. 3D cell culture system.
Breast Neoplasms
Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy.
Breast Neoplasms
Efficacy of novel methylenecyclohexenone derivatives as TrxR inhibitors in suppressing the proliferation and metastasis of human cancer cells.
Breast Neoplasms
Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer.
Breast Neoplasms
Gold(III) bis(thiosemicarbazonate) compounds in breast cancer cells: Cytotoxicity and thioredoxin reductase targeting.
Breast Neoplasms
Inhibition of Thioredoxin Reductase by Targeted Selenopolymeric Nanocarriers Synergizes the Therapeutic Efficacy of Doxorubicin in MCF7 Human Breast Cancer Cells.
Breast Neoplasms
Maintenance of S-nitrosothiol homeostasis plays an important role in growth suppression of estrogen receptor-positive breast tumors.
Breast Neoplasms
Methylseleninic acid (MSA) inhibits 17?-estradiol-induced cell growth in breast cancer T47D cells via enhancement of the antioxidative thioredoxin/ thioredoxin reductase system.
Breast Neoplasms
Multi-Targeted Anticancer Activity of Imidazolate Phosphane Gold(I) Compounds by Inhibition of DHFR and TrxR in Breast Cancer Cells.
Breast Neoplasms
Organotin complexes containing carboxylate ligands with maleimide and naphthalimide derived partial structures: TrxR inhibition, cytotoxicity and activity in resistant cancer cells.
Breast Neoplasms
Oxidative Stress Mediates through Apoptosis the Anticancer Effect of Phospho-Nonsteroidal Anti-Inflammatory Drugs: Implications for the Role of Oxidative Stress in the Action of Anticancer Agents.
Breast Neoplasms
pH-Sensitive Polymeric Nanoparticles with Gold(I) Compound Payloads Synergistically Induce Cancer Cell Death through Modulation of Autophagy.
Breast Neoplasms
Profilin-1 overexpression in MDA-MB-231 breast cancer cells is associated with alterations in proteomics biomarkers of cell proliferation, survival, and motility as revealed by global proteomics analyses.
Breast Neoplasms
Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer.
Breast Neoplasms
Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress.
Breast Neoplasms
Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy.
Breast Neoplasms
SEPP1 influences breast cancer risk among women with greater native american ancestry: the breast cancer health disparities study.
Breast Neoplasms
Sulforaphane, erucin, and iberin up-regulate thioredoxin reductase 1 expression in human MCF-7 cells.
Breast Neoplasms
Synergistic induction of apoptosis by combination treatment with mesupron and auranofin in human breast cancer cells.
Breast Neoplasms
Synthesis of mitochondria-targeted coumarin-3-carboxamide fluorescent derivatives: Inhibiting mitochondrial TrxR2 and cell proliferation on breast cancer cells.
Breast Neoplasms
Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer.
Breast Neoplasms
Targeting disseminated estrogen-receptor-positive breast cancer cells in bone marrow.
Breast Neoplasms
The role of functional polymorphisms in oxidative stress-related genes on early-stage breast cancer survival.
Breast Neoplasms
Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.
Breast Neoplasms
Thioredoxin and thioredoxin reductase influence estrogen receptor {alpha} mediated gene expression in human breast cancer cells.
Breast Neoplasms
Thioredoxin reductase and cancer cell growth inhibition by organotellurium antioxidants.
Breast Neoplasms
Thioredoxin system: a model for determining novel lead molecules for breast cancer chemotherapy.
Breast Neoplasms
Wogonin induces cellular senescence in breast cancer via suppressing TXNRD2 expression.
Bronchopulmonary Dysplasia
Hyperoxia induces thioredoxin and thioredoxin reductase gene expression in lungs of premature baboons with respiratory distress and bronchopulmonary dysplasia.
Bronchopulmonary Dysplasia
The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms.
Bronchopulmonary Dysplasia
Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia.
Candidiasis
Microbicidal activity of neutrophils is inhibited by isolates from recurrent vaginal candidiasis (RVVC) caused by Candida albicans through fungal thioredoxin reductase.
Carcinogenesis
Conditional expression of 15-lipoxygenase-1 inhibits the selenoenzyme thioredoxin reductase: modulation of selenoproteins by lipoxygenase enzymes.
Carcinogenesis
Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo.
Carcinogenesis
Differential epigenetic and transcriptional profile in MCF-7 breast cancer cells exposed to cadmium.
Carcinogenesis
Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent.
Carcinogenesis
Identification of Michael Acceptor-Centric Pharmacophores with Substituents That Yield Strong Thioredoxin Reductase Inhibitory Character Correlated to Antiproliferative Activity.
Carcinogenesis
Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation.
Carcinogenesis
Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium.
Carcinogenesis
Novel thioredoxin reductase inhibitor butaselen inhibits tumorigenesis by down-regulating programmed death-ligand 1 expression.
Carcinogenesis
Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer.
Carcinogenesis
Review: Exploring anticarcinogenic agents in a rat hepatocarcinogenesis model--focus on selenium and statins.
Carcinogenesis
Simvastatin inhibits the core promoter of the TXNRD1 gene and lowers cellular TrxR activity in HepG2 cells.
Carcinogenesis
Synthesis, SAR and biological evaluation of a novel series of 1-(2-chloroethyl)-1-nitroso-3-(2-(3-oxobenzoelenazol-2(3H)-yl)ethyl) urea: Organoselenium compounds for cancer therapy.
Carcinogenesis
Targeting thioredoxin reductase by deoxyelephantopin from Elephantopus scaber triggers cancer cell apoptosis.
Carcinogenesis
Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy.
Carcinoma
A thioredoxin reductase inhibitor induces growth inhibition and apoptosis in five cultured human carcinoma cell lines.
Carcinoma
Applying the designed multiple ligands approach to inhibit dihydrofolate reductase and thioredoxin reductase for anti-proliferative activity.
Carcinoma
Circ0120816 acts as an oncogene of esophageal squamous cell carcinoma by inhibiting miR-1305 and releasing TXNRD1.
Carcinoma
Differential expression of MAP3K7 and TROPONIN C proteins and related perturbations in renal amyloidosis.
Carcinoma
Dose-biomarker-response modeling of the anticancer effect of ethaselen in a human non-small cell lung cancer xenograft mouse model.
Carcinoma
Motexafin Gadolinium for the Treatment of Metastatic Renal Cell Carcinoma: Phase II Study Results.
Carcinoma
Organotin complexes containing carboxylate ligands with maleimide and naphthalimide derived partial structures: TrxR inhibition, cytotoxicity and activity in resistant cancer cells.
Carcinoma
Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma.
Carcinoma
Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II).
Carcinoma
Redox protein expression predicts progression-free and overall survival in ovarian cancer patients treated with platinum-based chemotherapy.
Carcinoma
The activity and tissue distribution of thioredoxin reductase in basal cell carcinoma.
Carcinoma
The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo.
Carcinoma
The Value of Thioredoxin Family Proteins and Proliferation Markers in Dysplastic and Malignant Gallbladders in Patients with Primary Sclerosing Cholangitis.
Carcinoma
Thioredoxin is associated with proliferation, p53 expression and negative estrogen and progesterone receptor status in breast carcinoma.
Carcinoma
Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells.
Carcinoma
Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma.
Carcinoma, Basal Cell
The activity and tissue distribution of thioredoxin reductase in basal cell carcinoma.
Carcinoma, Ehrlich Tumor
The 58 kDa mouse selenoprotein is a BCNU-sensitive thioredoxin reductase.
Carcinoma, Hepatocellular
10H-3,6-Diazaphenothiazine-Induced, Caspases-Mediated Mitochondrial-Dependent Apoptosis on HepG2 Hepatocellular Carcinoma Cells and Suppressed Cancer Cells Invasion via Inhibiting Mitochondrial Thioredoxin Reductase Enzymatic Activities.
Carcinoma, Hepatocellular
A new rhodium(I) NHC complex inhibits TrxR: In vitro cytotoxicity and in vivo hepatocellular carcinoma suppression.
Carcinoma, Hepatocellular
Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase.
Carcinoma, Hepatocellular
Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep3B cells by generation of reactive oxygen species.
Carcinoma, Hepatocellular
Comparison of thioredoxin reductases from Novikoff ascites hepatoma cells and normal liver of rats.
Carcinoma, Hepatocellular
Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo.
Carcinoma, Hepatocellular
Differential thioredoxin reductase activity from human normal hepatic and hepatoma cell lines.
Carcinoma, Hepatocellular
Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells.
Carcinoma, Hepatocellular
Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase.
Carcinoma, Hepatocellular
Induction of Oxidative Stress via Inhibition of Thioredoxin Reductase 1 is an Effective Therapeutic Approach for Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Inhibition of Both Thioredoxin Reductase and Glutathione Reductase may Contribute to the Anticancer Mechanism of TH-302.
Carcinoma, Hepatocellular
Inhibition of glutathione synthesis eliminates the adaptive response of ascitic hepatoma 22 cells to nedaplatin that targets thioredoxin reductase.
Carcinoma, Hepatocellular
Inhibitory effects of thioredoxin reductase antisense RNA on the growth of human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Loss of activity of the selenoenzyme thioredoxin reductase causes induction of hepatic heme oxygenase-1.
Carcinoma, Hepatocellular
miR-125b-5p inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma via targeting TXNRD1.
Carcinoma, Hepatocellular
Nano red elemental selenium has no size effect in the induction of seleno-enzymes in both cultured cells and mice.
Carcinoma, Hepatocellular
Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas.
Carcinoma, Hepatocellular
PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway.
Carcinoma, Hepatocellular
Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress.
Carcinoma, Hepatocellular
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Hepatocellular
Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.
Carcinoma, Hepatocellular
SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC.
Carcinoma, Hepatocellular
Synergy between sulforaphane and selenium in the up-regulation of thioredoxin reductase and protection against hydrogen peroxide-induced cell death in human hepatocytes
Carcinoma, Hepatocellular
Synergy between sulforaphane and selenium in the up-regulation of thioredoxin reductase and protection against hydrogen peroxide-induced cell death in human hepatocytes.
Carcinoma, Hepatocellular
Synthesis and biological evaluation of gold(III) Schiff base complexes for the treatment of hepatocellular carcinoma through attenuating TrxR activity.
Carcinoma, Hepatocellular
Thioredoxin alters the matrix metalloproteinase/tissue inhibitors of metalloproteinase balance and stimulates human SK-N-SH neuroblastoma cell invasion.
Carcinoma, Hepatocellular
Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element.
Carcinoma, Hepatocellular
Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy.
Carcinoma, Hepatocellular
Thioredoxin reductase: a novel, independent prognostic marker in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Toxicological effects of thiomersal and ethylmercury: Inhibition of the thioredoxin system and NADP(+)-dependent dehydrogenases of the pentose phosphate pathway.
Carcinoma, Hepatocellular
TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.
Carcinoma, Hepatocellular
TXNRD1 Is an Unfavorable Prognostic Factor for Patients with Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
[Correlation of plasma thioredoxin reductase activity to growth of H22 hepatocellular carcinoma xenografts in Kunming mice.]
Carcinoma, Hepatocellular
[Preliminary study on cellular status of selenium and oxidative stress in human hepatocellular carcinoma and normal liver]
Carcinoma, Lewis Lung
Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo.
Carcinoma, Non-Small-Cell Lung
Dose-biomarker-response modeling of the anticancer effect of ethaselen in a human non-small cell lung cancer xenograft mouse model.
Carcinoma, Non-Small-Cell Lung
Expression profiles of thioredoxin family proteins in human lung cancer tissue: correlation with proliferation and differentiation.
Carcinoma, Non-Small-Cell Lung
MicroRNA-124 regulates the radiosensitivity of non-small cell lung cancer cells by targeting TXNRD1.
Carcinoma, Non-Small-Cell Lung
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Non-Small-Cell Lung
Selenium-containing thioredoxin reductase inhibitor ethaselen sensitizes non-small cell lung cancer to radiotherapy.
Carcinoma, Non-Small-Cell Lung
Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway.
Carcinoma, Non-Small-Cell Lung
Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
The serum activity of thioredoxin reductases 1 (TrxR1) is correlated with the poor prognosis in EGFR wild-type and ALK negative non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Thioredoxin Reductase as a Novel and Efficient Plasma Biomarker for the Detection of Non-Small Cell Lung Cancer: a Large-scale, Multicenter study.
Carcinoma, Non-Small-Cell Lung
Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma.
Carcinoma, Ovarian Epithelial
BRCA1 deficiency increases the sensitivity of ovarian cancer cells to auranofin.
Carcinoma, Renal Cell
Motexafin Gadolinium for the Treatment of Metastatic Renal Cell Carcinoma: Phase II Study Results.
Carcinoma, Squamous Cell
Differential expression of MAP3K7 and TROPONIN C proteins and related perturbations in renal amyloidosis.
Carcinoma, Squamous Cell
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Squamous Cell
Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells.
Cardiomyopathy, Dilated
Consequences of mutations and inborn errors of selenoprotein biosynthesis and functions.
Cardiomyopathy, Dilated
Did a shared thioredoxin-reductase gene mutation lead to maternal peripartum cardiomyopathy and fatal dilated cardiomyopathy in her son? A case report.
Cardiomyopathy, Dilated
Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function.
Cardiomyopathy, Dilated
Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium.
Cardiomyopathy, Dilated
Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protection.
Cardiomyopathy, Dilated
Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy.
Cardiotoxicity
Cyclophosphamide-evoked heart failure involves pronounced co-suppression of cytoplasmic thioredoxin reductase activity and non-protein free thiol level.
Cardiovascular Diseases
Astaxanthin prevents changes in the activities of thioredoxin reductase and paraoxonase in hypercholesterolemic rabbits.
Cardiovascular Diseases
Distinctive Under-Expression Profile of Inflammatory and Redox Genes in the Blood of Elderly Patients with Cardiovascular Disease.
Cardiovascular Diseases
Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase.
Cardiovascular Diseases
Selenium supplementation does not improve vascular responsiveness in healthy North American men.
Cardiovascular Diseases
Selenoproteins and human health: Insights from epidemiological data.
Cataract
DNA hypermethylation-mediated downregulation of antioxidant genes contributes to the early onset of cataracts in highly myopic eyes.
Cataract
Effects of Sodium Selenite on Oxidative Damage in the Liver, Kidney and Brain in a Selenite Cataract Rat Model.
Cataract
Oral consumption of ?-glucosyl-hesperidin could prevent lens hardening, which causes presbyopia.
Cataract
Sulforaphane-induced transcription of thioredoxin reductase in lens: possible significance against cataract formation.
Cataract
Thioredoxin, thioredoxin reductase, and alpha-crystallin revive inactivated glyceraldehyde 3-phosphate dehydrogenase in human aged and cataract lens extracts.
Cerebrovascular Disorders
DNA Hypomethylation of the MPO Gene in Peripheral Blood Leukocytes Is Associated with Cerebral Stroke in the Acute Phase.
Chemical and Drug Induced Liver Injury
Genetic Variations in TXNRD1 as Potential Predictors of Drug-Induced Liver Injury.
Cholangiocarcinoma
Altered expression of thioredoxin reductase-1 in dysplastic bile ducts and cholangiocarcinoma in a hamster model.
Colonic Neoplasms
Bile acids mimic oxidative stress induced upregulation of thioredoxin reductase in colon cancer cell lines.
Colonic Neoplasms
Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer.
Colonic Neoplasms
Curcuminoid WZ26, a TrxR1 inhibitor, effectively inhibits colon cancer cell growth and enhances cisplatin-induced cell death through the induction of ROS.
Colonic Neoplasms
Enhancement of the efficacy of mitomycin C-mediated apoptosis in human colon cancer cells with RNAi-based thioredoxin reductase 1 deficiency.
Colonic Neoplasms
Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators.
Colonic Neoplasms
Isodeoxyelephantopin Inactivates Thioredoxin Reductase 1 and Activates ROS-Mediated JNK Signaling Pathway to Exacerbate Cisplatin Effectiveness in Human Colon Cancer Cells.
Colonic Neoplasms
JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1.
Colonic Neoplasms
Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells.
Colonic Neoplasms
The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways.
Colonic Neoplasms
Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.
Colonic Neoplasms
Thioredoxin reductase 1 ablation sensitizes colon cancer cells to methylseleninate-mediated cytotoxicity.
Colonic Neoplasms
Thioredoxin reductase 1 expression in colon cancer: discrepancy between in vitro and in vivo findings.
Colonic Neoplasms
Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles.
Colonic Neoplasms
Thioredxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest.
Colorectal Neoplasms
Aberrant expression of selenoproteins in the progression of colorectal cancer.
Colorectal Neoplasms
Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation.
Colorectal Neoplasms
Licochalcone a Induces ROS-Mediated Apoptosis through TrxR1 Inactivation in Colorectal Cancer Cells.
Colorectal Neoplasms
Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells.
Colorectal Neoplasms
Selenite induces apoptosis in colorectal cancer cells through interaction with thioredoxin reductase.
Colorectal Neoplasms
Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.
Congenital Abnormalities
Characterizing the effects of titanium dioxide and silver nanoparticles released from painted surfaces due to weathering on zebrafish (Danio rerio).
Corneal Dystrophies, Hereditary
[Oxidative stress in the pathogenesis of Fuchs endothelial corneal dystrophy].
Cystitis
Cyclophosphamide suppresses thioredoxin reductase in bladder tissue and its adaptive response via inductions of thioredoxin reductase and glutathione peroxidase.
Diabetes Mellitus
Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus.
Diabetes Mellitus
Single nucleotide polymorphisms in the Trx2/TXNIP and TrxR2 genes of the mitochondrial thioredoxin antioxidant system and the risk of diabetic retinopathy in patients with Type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Single nucleotide polymorphisms in the Trx2/TXNIP and TrxR2 genes of the mitochondrial thioredoxin antioxidant system and the risk of diabetic retinopathy in patients with Type 2 diabetes mellitus.
Diabetes, Gestational
miR?875?5p regulates IR and inflammation via targeting TXNRD1 in gestational diabetes rats.
Diabetic Retinopathy
Single nucleotide polymorphisms in the Trx2/TXNIP and TrxR2 genes of the mitochondrial thioredoxin antioxidant system and the risk of diabetic retinopathy in patients with Type 2 diabetes mellitus.
DiGeorge Syndrome
Haplotypic association spanning the 22q11.21 genes COMT and ARVCF with schizophrenia.
Diphtheria
Thioredoxin reductase inhibitor auranofin prevents membrane transport of diphtheria toxin into the cytosol and protects human cells from intoxication.
Drug Hypersensitivity
Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions.
Duodenal Ulcer
Deep-sea water containing selenium provides intestinal protection against duodenal ulcers through the upregulation of Bcl-2 and thioredoxin reductase 1.
Encephalomyelitis
Compensatory Neuroprotective Response of Thioredoxin Reductase against Oxidative-Nitrosative Stress Induced by Experimental Autoimmune Encephalomyelitis in Rats: Modulation by Theta Burst Stimulation.
Encephalomyelitis, Autoimmune, Experimental
Compensatory Neuroprotective Response of Thioredoxin Reductase against Oxidative-Nitrosative Stress Induced by Experimental Autoimmune Encephalomyelitis in Rats: Modulation by Theta Burst Stimulation.
Endometriosis
Association between the Genetic Variants of Glutathione Peroxidase 4 and Severity of Endometriosis.
Epilepsy
Changes in the Expression of Selenoproteins in Mesial Temporal Lobe Epilepsy Patients.
Epilepsy, Generalized
Consequences of mutations and inborn errors of selenoprotein biosynthesis and functions.
Epilepsy, Generalized
Homozygous mutation in TXNRD1 is associated with genetic generalized epilepsy.
Epilepsy, Temporal Lobe
Changes in the Expression of Selenoproteins in Mesial Temporal Lobe Epilepsy Patients.
Esophageal Squamous Cell Carcinoma
Circ0120816 acts as an oncogene of esophageal squamous cell carcinoma by inhibiting miR-1305 and releasing TXNRD1.
Fibrosarcoma
Cytotoxicity induced by inhibition of thioredoxin reductases via multiple signaling pathways: role of cytosolic phospholipase A(2)alpha-dependent and -independent release of arachidonic acid.
Filariasis
A review on the druggability of a thiol-based enzymatic antioxidant thioredoxin reductase for treating filariasis and other parasitic infections.
Friedreich Ataxia
Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function.
Fuchs' Endothelial Dystrophy
[Oxidative stress in the pathogenesis of Fuchs endothelial corneal dystrophy].
Glaucoma
Association analysis of variants rs35934224 in TXNRD2 and rs6478746 in LMX1B in primary angle-closure and pseudoexfoliation glaucoma.
Glaucoma
Mitochondrial function is impaired in the primary visual cortex in an experimental glaucoma model.
Glaucoma, Open-Angle
Association analysis of variants rs35934224 in TXNRD2 and rs6478746 in LMX1B in primary angle-closure and pseudoexfoliation glaucoma.
Glaucoma, Open-Angle
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.
Glaucoma, Open-Angle
Lack of Association Between Polymorphisms in TXNRD2 and LMX1B and Primary Open-Angle Glaucoma in a Saudi Cohort.
Glaucoma, Open-Angle
TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population.
Glioblastoma
Antiglioma activity of 2,2':6',2"-terpyridineplatinum(II) complexes in a rat model-Effects on cellular redox metabolism.
Glioblastoma
Human thioredoxin reductase is efficiently inhibited by (2,2':6',2' '-terpyridine)platinum(II) complexes. Possible implications for a novel antitumor strategy.
Glioblastoma
Inhibition of reductase systems by 2-AAPA modulates peroxiredoxin oxidation and mitochondrial function in A172 glioblastoma cells.
Glioblastoma
Intratumoral hemorrhage-related differences in the expression of vascular endothelial growth factor, basic fibroblast growth factor and thioredoxin reductase 1 in human glioblastoma.
Glioblastoma
New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?
Glioblastoma
Thioredoxin System Protein Expression Is Associated with Poor Clinical Outcome in Adult and Paediatric Gliomas and Medulloblastomas.
Glioblastoma
Tissue and Plasma Thioredoxin Reductase Expressions in Patients with Glioblastoma Multiforme.
Glioblastoma
Tissue thioredoxin reductase-1 expression in astrocytomas of different grades.
Glioma
(1-4)-Thiodisaccharides as anticancer agents. Part 5. Evaluation of anticancer activity and investigation of mechanism of action.
Glioma
Efficient identification of novel anti-glioma lead compounds by machine learning models.
Glioma
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin ?-2 Expression, and Induce Antitumor Effects against Human Glioma.
Glioma
Novel TrxR1 Inhibitors Show Potential for Glioma Treatment by Suppressing the Invasion and Sensitizing Glioma Cells to Chemotherapy.
Glioma
Thioredoxin System Protein Expression Is Associated with Poor Clinical Outcome in Adult and Paediatric Gliomas and Medulloblastomas.
Glioma
TIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport.
Heart Failure
Cyclophosphamide-evoked heart failure involves pronounced co-suppression of cytoplasmic thioredoxin reductase activity and non-protein free thiol level.
Heart Failure
Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium.
Heart Failure
Thioredoxin Reductase 2 (Txnrd2) Regulates Mitochondrial Integrity in the Progression of Age-Related Heart Failure.
Hermanski-Pudlak Syndrome
Regulation of thioredoxin reductase by calcium in Hermansky-Pudlak syndrome.
Hermanski-Pudlak Syndrome
Thioredoxin reductase activity in Hermansky-Pudlak syndrome: a method for identification of putative heterozygotes.
HIV Infections
Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120.
Hyperglycemia
Hyperglycemia in a type 1 Diabetes Mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain.
Hypersensitivity
A novel NADPH thioredoxin reductase, localized in the chloroplast, which deficiency causes hypersensitivity to abiotic stress in Arabidopsis thaliana.
Hypersensitivity
Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions.
Hypertension
Augmented S-nitrosylation contributes to impaired relaxation in angiotensin II hypertensive mouse aorta: role of thioredoxin reductase.
Hypertension
THIOREDOXIN REDUCTASE INHIBITION REDUCES RELAXATION BY INCREASING OXIDATIVE STRESS AND S-NITROSYLATION IN MOUSE AORTA.
Hypopigmentation
Thioredoxin reductase. Role in free radical reduction in different hypopigmentation disorders.
Hypothyroidism
Diphenyl Diselenide Modulates Gene Expression of Antioxidant Enzymes in the Cerebral Cortex, Hippocampus and Striatum of Female Hypothyroid Rats.
Infections
A review on the druggability of a thiol-based enzymatic antioxidant thioredoxin reductase for treating filariasis and other parasitic infections.
Infections
Auranofin inactivates Trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo.
Infections
Biochemical mechanisms and therapeutic potential of pseudohalide thiocyanate in human health.
Infections
Decreased selenoprotein expression alters the immune response during influenza virus infection in mice.
Infections
Differential expression profiles in the midgut of Triatoma infestans infected with Trypanosoma cruzi.
Infections
Histone Methyltransferase SET8 Epigenetically Reprograms Host Immune Responses to Assist Mycobacterial Survival.
Infections
Identification of a thioredoxin reductase from Babesia microti during mammalian infection.
Infections
Insights into the fish thioredoxin system: expression profile of thioredoxin and thioredoxin reductase in rainbow trout (Oncorhynchus mykiss) during infection and in vitro stimulation.
Infections
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.
Infections
The Essential Thioredoxin Reductase of the Human Pathogenic Mold Aspergillus fumigatus Is a Promising Antifungal Target.
Infections
The Redox Systems of Plasmodium falciparum and Plasmodium vivax: Comparison, In silico Analyses and Inhibitor Studies.
Infections
Thioredoxin reductase gene expression and activity among human T-cell lymphotropic virus type 1-infected patients.
Infections
Thioredoxin Reductase Is a Valid Target for Antimicrobial Therapeutic Development Against Gram-Positive Bacteria.
Infections
TrxR, a new CovR-repressed response regulator that activates the Mga virulence regulon in group A Streptococcus.
Insulin Resistance
GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity.
Insulin Resistance
High-fat diet-induced changes in liver thioredoxin and thioredoxin reductase as a novel feature of insulin resistance.
Insulin Resistance
miR?875?5p regulates IR and inflammation via targeting TXNRD1 in gestational diabetes rats.
Insulin Resistance
Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness.
Insulinoma
Thioredoxin-mimetic peptides (TXM) reverse auranofin induced apoptosis and restore insulin secretion in insulinoma cells.
Iron Overload
Thalassemia major patients using iron chelators showed a reduced plasma thioredoxin level and reduced thioredoxin reductase activity, despite elevated oxidative stress.
Ischemic Attack, Transient
Comparison of the Immunoreactivity of Trx2/Prx3 Redox System in the Hippocampal CA1 Region Between the Young and Adult Gerbil Induced by Transient Cerebral Ischemia.
Kashin-Beck Disease
Patients with Osteoarthritis and Kashin-Beck Disease Display Distinct CpG Methylation Profiles in the DIO2, GPX3, and TXRND1 Promoter Regions.
Kashin-Beck Disease
The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease.
Kashin-Beck Disease
[TrxR2 gene polymorphisms may not be associated with the susceptibility to Kashin-Beck disease.]
Kidney Failure, Chronic
Differential expression of MAP3K7 and TROPONIN C proteins and related perturbations in renal amyloidosis.
Latent Infection
Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity.
Leukemia
A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells.
Leukemia
Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.
Leukemia
Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells.
Leukemia
Targeting thioredoxin reductase by plumbagin contributes to inducing apoptosis of HL-60 cells.
Leukemia
The selenoprotein thioredoxin reductase is expressed in peripheral blood monocytes and THP1 human myeloid leukemia cells--regulation by 1,25-dihydroxyvitamin D3 and selenite.
Leukemia
Thioredoxin reductase, a redox-active selenoprotein, is secreted by normal and neoplastic cells: presence in human plasma.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Inhibition of thioredoxin reductase by auranofin induces apoptosis in adriamycin-resistant human K562 chronic myeloid leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Effect of Nrf2 and TrxR on proliferation of chronic myeloid leukemia cell and its mechanism].
Leukemia, Myeloid
The selenoprotein thioredoxin reductase is expressed in peripheral blood monocytes and THP1 human myeloid leukemia cells--regulation by 1,25-dihydroxyvitamin D3 and selenite.
Leukemia, Myeloid, Acute
Peperomin E and its orally bioavailable analog induce oxidative stress-mediated apoptosis of acute myeloid leukemia progenitor cells by targeting thioredoxin reductase.
Leukemia, Myeloid, Acute
The novel thioredoxin reductase inhibitor A-Z2 triggers intrinsic apoptosis and shows efficacy in the treatment of acute myeloid leukemia.
Leukemia, T-Cell
The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation.
Liver Cirrhosis
Therapeutic Effects of an Inhibitor of Thioredoxin Reductase on Liver Fibrosis by Inhibiting the Transforming Growth Factor-?1/Smads Pathway.
Liver Neoplasms
10H-3,6-Diazaphenothiazine-Induced, Caspases-Mediated Mitochondrial-Dependent Apoptosis on HepG2 Hepatocellular Carcinoma Cells and Suppressed Cancer Cells Invasion via Inhibiting Mitochondrial Thioredoxin Reductase Enzymatic Activities.
Liver Neoplasms
Clinical application of thioredoxin reductase as a novel biomarker in liver cancer.
Liver Neoplasms
Inhibiting TrxR suppresses liver cancer by inducing apoptosis and eliciting potent antitumor immunity.
Liver Neoplasms
TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.
Lung Diseases
Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition.
Lung Injury
Alleviation of lung injury by glycyrrhizic acid in benzo(a)pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase.
Lung Injury
Effects of hyperoxia on cytoplasmic thioredoxin system in alveolar type epithelial cells of premature rats.
Lung Injury
Pulmonary injury and antioxidant response in mice exposed to arsenate and hexavalent chromium and their combination.
Lung Injury
Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition.
Lung Injury
The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms.
Lung Injury
The Thioredoxin Reductase-1 Inhibitor Aurothioglucose Attenuates Lung Injury and Improves Survival in a Murine Model of Acute Respiratory Distress Syndrome.
Lung Injury
Thioredoxin Reductase Inhibition Attenuates Neonatal Hyperoxic Lung Injury and Enhances Nuclear Factor E2-Related Factor 2 Activation.
Lung Injury
Thioredoxin reductase inhibition elicits nrf2-mediated responses in clara cells: implications for oxidant-induced lung injury.
Lung Neoplasms
Auranofin inhibits the proliferation of lung cancer cells via necrosis and caspase?dependent apoptosis.
Lung Neoplasms
Discovery of New Monocarbonyl Ligustrazine-Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer.
Lung Neoplasms
Dose-biomarker-response modeling of the anticancer effect of ethaselen in a human non-small cell lung cancer xenograft mouse model.
Lung Neoplasms
Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity. Effects on thioredoxin reductase and glutathione reductase.
Lung Neoplasms
Effects of redox modulation by inhibition of Thioredoxin reductase on radiosensitivity and gene expression.
Lung Neoplasms
Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo.
Lung Neoplasms
Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent.
Lung Neoplasms
Expression profiles of thioredoxin family proteins in human lung cancer tissue: correlation with proliferation and differentiation.
Lung Neoplasms
Inhibition of TrxR2 suppressed NSCLC cell proliferation, metabolism and induced cell apoptosis through decreasing antioxidant activity.
Lung Neoplasms
KEAP1-Dependent Synthetic Lethality Induced by AKT and TXNRD1 Inhibitors in Lung Cancer.
Lung Neoplasms
Long-term study of ovine pulmonary adenocarcinogenesis in sheep with marginal vs. sufficient nutritional selenium supply: Results from computed tomography, pathology, immunohistochemistry, JSRV-PCR and lung biochemistry.
Lung Neoplasms
Mammalian thioredoxin reductase alters cytolytic activity of an antibacterial peptide.
Lung Neoplasms
Menin?MLL inhibitors induce ferroptosis and enhance the anti?proliferative activity of auranofin in several types of cancer cells.
Lung Neoplasms
MicroRNA-124 regulates the radiosensitivity of non-small cell lung cancer cells by targeting TXNRD1.
Lung Neoplasms
microRNA-130b-3p Contained in MSC-Derived EVs Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis.
Lung Neoplasms
miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2.
Lung Neoplasms
Selenium-containing thioredoxin reductase inhibitor ethaselen sensitizes non-small cell lung cancer to radiotherapy.
Lung Neoplasms
Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway.
Lung Neoplasms
Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells.
Lung Neoplasms
The serum activity of thioredoxin reductases 1 (TrxR1) is correlated with the poor prognosis in EGFR wild-type and ALK negative non-small cell lung cancer.
Lung Neoplasms
Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction.
Lung Neoplasms
Thioredoxin Reductase as a Novel and Efficient Plasma Biomarker for the Detection of Non-Small Cell Lung Cancer: a Large-scale, Multicenter study.
Lung Neoplasms
Treatment of lung cancer cells with cytotoxic levels of sodium selenite: effects on the thioredoxin system.
Lymphatic Metastasis
Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.
Lymphatic Metastasis
[Expression of thioredoxin reductase 1 (TrxR1) in gastric cancer and its effect on the growth of gastric cancer cells].
Lymphoma
Investigating the Thioredoxin and Glutathione Systems' Response in Lymphoma Cells after Treatment with [Au(d2pype)2]CL.
Lymphoma
Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates.
Lymphoma, B-Cell
Nitro aspirin (NCX4040) induces apoptosis in PC3 metastatic prostate cancer cells via hydrogen peroxide (H2O2)-mediated oxidative stress.
Malaria
Acid-base catalysis in the mechanism of thioredoxin reductase from Drosophila melanogaster.
Malaria
Discovery and biochemical characterization of Plasmodium thioredoxin reductase inhibitors from an antimalarial set.
Malaria
Identification of acid-base catalytic residues of high-Mr thioredoxin reductase from Plasmodium falciparum.
Malaria
Identification of Oleamide in Guatteria recurvisepala by LC/MS-Based Plasmodium falciparum Thioredoxin Reductase Ligand Binding Method.
Malaria
Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity.
Malaria
Plasmodium falciparum Thioredoxin Reductase (PfTrxR) and Its Role as a Target for New Antimalarial Discovery.
Malaria
Preliminary LC-MS Based Screening for Inhibitors of Plasmodium falciparum Thioredoxin Reductase (PfTrxR) among a Set of Antimalarials from the Malaria Box.
Malaria
Synthesis of 5,5'-dithiobis(2-nitrobenzamides) as alternative substrates for trypanothione reductase and thioredoxin reductase: a microtiter colorimetric assay for inhibitor screening.
Malaria
The malaria parasite Plasmodium falciparum possesses a functional thioredoxin system.
Malaria
Thioredoxin, thioredoxin reductase, and thioredoxin peroxidase of malaria parasite Plasmodium falciparum.
Medulloblastoma
Thioredoxin System Protein Expression Is Associated with Poor Clinical Outcome in Adult and Paediatric Gliomas and Medulloblastomas.
Melanoma
A Diselenide Turn-On Fluorescent Probe for the Detection of Thioredoxin Reductase.
Melanoma
Accessing the transcriptional status of selenoproteins in skin cancer-derived cell lines.
Melanoma
Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells.
Melanoma
Evaluation of N-acetyl-S-(p-chlorophenylcarbamoyl)cysteine as an irreversible inhibitor of mammalian thioredoxin reductase1.
Melanoma
New aspects in the pathophysiology of cutaneous melanoma: a review of the role of thioproteins and the effect of nitrosoureas.
Melanoma
Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.
Melanoma
Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase.
Melanoma
Sensitivity and resistance in human metastatic melanoma to the new chloroethylnitrosourea anti-tumor drug Fotemustine.
Melanoma
The activity and purification of membrane-associated thioredoxin reductase from human metastatic melanotic melanoma.
Melanoma
The stereospecific suicide inhibition of human melanoma thioredoxin reductase by 13-cis-retinoic acid.
Melanoma
Thioredoxin reductase activity at the surface of human primary cutaneous melanomas and their surrounding skin.
Melanoma
Thioredoxin reductase induction coincides with melanin biosynthesis in brown and black guinea pigs and in murine melanoma cells.
Melanoma
Thioredoxin reductase, a redox-active selenoprotein, is secreted by normal and neoplastic cells: presence in human plasma.
Melanoma
Thioredoxin, thioredoxin reductase and tumour necrosis factor-alpha expression in melanoma cells: correlation to resistance against cytotoxic attack.
Melanoma
Triphenylphosphonium derivatives disrupt metabolism and inhibit melanoma growth in vivo when delivered via a thermosensitive hydrogel.
Melanoma, Amelanotic
The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase.
Meningioma
High thioredoxin reductase 1 expression in meningiomas undergoing malignant progression.
Mercury Poisoning
Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning.
Mesothelioma
Auranofin induces mesothelioma cell death through oxidative stress and GSH depletion.
Mesothelioma
Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma.
Mesothelioma, Malignant
Quantification of alternative mRNA species and identification of thioredoxin reductase 1 isoforms in human tumor cells.
Mesothelioma, Malignant
Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma.
Multiple Myeloma
Anticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma.
Multiple Myeloma
Cross-talk between two antioxidants, thioredoxin reductase and heme oxygenase-1, and therapeutic implications for multiple myeloma.
Multiple Myeloma
Mitochondrial thioredoxin reductase regulates major cytotoxicity pathways of proteasome inhibitors in multiple myeloma cells.
Multiple Myeloma
TrxR1 inhibition overcomes both hypoxia-induced and acquired bortezomib resistance in multiple myeloma through NF-?? inhibition.
Muscular Diseases
Why 21? The significance of selenoproteins for human health revealed by inborn errors of metabolism.
Myocardial Infarction
Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus.
Nasal Polyps
Expression and distribution of thioredoxin and thioredoxin reductase in human nasal mucosa and nasal polyp.
Nasopharyngeal Carcinoma
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Neoplasm Metastasis
Anti-recurrence/metastasis and chemosensitization therapy with thioredoxin reductase-interfering drug delivery system.
Neoplasm Metastasis
Auranofin improves overall survival when combined with standard of care in a pilot study involving dogs with osteosarcoma.
Neoplasm Metastasis
Clinical application of thioredoxin reductase as a novel biomarker in liver cancer.
Neoplasm Metastasis
Efficacy of novel methylenecyclohexenone derivatives as TrxR inhibitors in suppressing the proliferation and metastasis of human cancer cells.
Neoplasm Metastasis
Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy.
Neoplasm Metastasis
Mutational landscape and potential therapeutic targets for sporadic pancreatic neuroendocrine tumors based on target next-generation sequencing.
Neoplasm Metastasis
New aspects in the pathophysiology of cutaneous melanoma: a review of the role of thioproteins and the effect of nitrosoureas.
Neoplasm Metastasis
Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation.
Neoplasm Metastasis
The activity and purification of membrane-associated thioredoxin reductase from human metastatic melanotic melanoma.
Neoplasm Metastasis
The role of thioredoxin reductase 1 in melanoma metabolism and metastasis.
Neoplasm Metastasis
Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.
Neoplasm Metastasis
[Expression of thioredoxin reductase 1 (TrxR1) in gastric cancer and its effect on the growth of gastric cancer cells].
Neoplasms
10H-3,6-Diazaphenothiazine-Induced, Caspases-Mediated Mitochondrial-Dependent Apoptosis on HepG2 Hepatocellular Carcinoma Cells and Suppressed Cancer Cells Invasion via Inhibiting Mitochondrial Thioredoxin Reductase Enzymatic Activities.
Neoplasms
2a, a novel curcumin analog, sensitizes cisplatin-resistant A549 cells to cisplatin by inhibiting thioredoxin reductase concomitant oxidative stress damage.
Neoplasms
3-Nitro-2H-chromenes as a New Class of Inhibitors against Thioredoxin Reductase and Proliferation of Cancer Cells.
Neoplasms
3D QSAR and pharmacophore study of curcuminoids and curcumin analogs: interaction with thioredoxin reductase.
Neoplasms
A Comparison of the Inhibitory Effects of Anti-Cancer Drugs on Thioredoxin Reductase and Glutathione S-Transferase in Rat Liver.
Neoplasms
A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis.
Neoplasms
A Gold(I) Complex Containing an Oleanolic Acid Derivative as a Potential Anti-ovarian Cancer Agent via Inhibiting TrxR and Activating ROS-mediated ERS.
Neoplasms
A new mechanism of action for the anticancer drug mitomycin C: mechanism-based inhibition of thioredoxin reductase.
Neoplasms
A new rhodium(I) NHC complex inhibits TrxR: In vitro cytotoxicity and in vivo hepatocellular carcinoma suppression.
Neoplasms
A novel organoselenium compound induces cell cycle arrest and apoptosis in prostate cancer cell lines.
Neoplasms
A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells.
Neoplasms
A pan-cancer study of selenoprotein genes as promising targets for cancer therapy.
Neoplasms
A thioredoxin reductase inhibitor induces growth inhibition and apoptosis in five cultured human carcinoma cell lines.
Neoplasms
Activation of TAp73 and inhibition of TrxR by Verteporfin for improved cancer therapy in TP53 mutant pancreatic tumors.
Neoplasms
Adipocytokines, inflammatory, epigenetic instability & angiogenesis biomarkers in type 2 diabetic Egyptian women with breast cancer.
Neoplasms
Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities.
Neoplasms
Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a.
Neoplasms
Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase.
Neoplasms
Annatto Constituent Cis-Bixin has Selective Anticancer Effects Mediated by Oxidative Stress and Associated with Inhibition of Thioredoxin and Thioredoxin Reductase.
Neoplasms
Anti-recurrence/metastasis and chemosensitization therapy with thioredoxin reductase-interfering drug delivery system.
Neoplasms
Anticancer and Antiangiogenic Iron(II) Complexes That Target Thioredoxin Reductase to Trigger Cancer Cell Apoptosis.
Neoplasms
Antiglioma activity of 2,2':6',2"-terpyridineplatinum(II) complexes in a rat model-Effects on cellular redox metabolism.
Neoplasms
Antioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell lines.
Neoplasms
Antioxidant enzymes in oligodendroglial brain tumors: association with proliferation, apoptotic activity and survival.
Neoplasms
Applying the designed multiple ligands approach to inhibit dihydrofolate reductase and thioredoxin reductase for anti-proliferative activity.
Neoplasms
APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase.
Neoplasms
Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase.
Neoplasms
Augmented antitumor effects of combination therapy of cisplatin with ethaselen as a novel thioredoxin reductase inhibitor on human A549 cell in vivo.
Neoplasms
Auranofin inhibits the proliferation of lung cancer cells via necrosis and caspase?dependent apoptosis.
Neoplasms
Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species.
Neoplasms
Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep3B cells by generation of reactive oxygen species.
Neoplasms
Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties.
Neoplasms
Bimetallic titanocene-gold phosphane complexes inhibit invasion, metastasis, and angiogenesis-associated signaling molecules in renal cancer.
Neoplasms
Bioorthogonal Activation of Dual Catalytic and Anti-Cancer Activities of Organogold(I) Complexes in Living Systems.
Neoplasms
Bis-anthracycline WP760 abrogates melanoma cell growth by transcription inhibition, p53 activation and IGF1R downregulation.
Neoplasms
Butyltin(IV) benzoates: inhibition of thioredoxin reductase, tumor cell growth inhibition, and interactions with proteins.
Neoplasms
Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase.
Neoplasms
Carbon Dot Based, Naphthalimide Coupled FRET Pair for Highly Selective Ratiometric Detection of Thioredoxin Reductase and Cancer Screening.
Neoplasms
Carbon dots as analytical tools for sensing of thioredoxin reductase and screening of cancer cells.
Neoplasms
Cell line-directed screening assay for inhibitors of thioredoxin reductase signaling as potential anti-cancer drugs.
Neoplasms
Certain (-)-epigallocatechin-3-gallate (EGCG) auto-oxidation products (EAOPs) retain the cytotoxic activities of EGCG.
Neoplasms
Characterization of Hydrophilic Gold(I) N-Heterocyclic Carbene (NHC) Complexes as Potent TrxR Inhibitors Using Biochemical and Mass Spectrometric Approaches.
Neoplasms
Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells.
Neoplasms
Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention.
Neoplasms
Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures.
Neoplasms
Clinical application of thioredoxin reductase as a novel biomarker in liver cancer.
Neoplasms
Clinical utility of antioxidant gene expression levels in circulating cancer cell clusters for the detection of prostate cancer in patients with prostate-specific antigen levels of 4-10 ng/mL and disease prognostication after radical prostatectomy.
Neoplasms
Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer.
Neoplasms
Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity.
Neoplasms
Compensatory combination of mTOR and TrxR inhibitors to cause oxidative stress and regression of tumors.
Neoplasms
Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells.
Neoplasms
Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer.
Neoplasms
Cross-talk between Bcr-abl and the Thioredoxin System in Chronic Myeloid Leukaemia: Implications for CML Treatment.
Neoplasms
Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism.
Neoplasms
Curcuminoid WZ35 synergize with cisplatin by inducing ROS production and inhibiting TrxR1 activity in gastric cancer cells.
Neoplasms
Current Progresses in Metal-based Anticancer Complexes as Mammalian TrxR Inhibitors.
Neoplasms
CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide.
Neoplasms
Cyclodextrin-derived diorganyl tellurides as glutathione peroxidase mimics and inhibitors of thioredoxin reductase and cancer cell growth.
Neoplasms
Cyclophosphamide-evoked heart failure involves pronounced co-suppression of cytoplasmic thioredoxin reductase activity and non-protein free thiol level.
Neoplasms
D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H2O2-mediated oxidative stress.
Neoplasms
Decreased expression of antioxidant enzymes is associated with aggressive features in ependymomas.
Neoplasms
Design and SAR of Withangulatin A Analogues that Act as Covalent TrxR Inhibitors through the Michael Addition Reaction Showing Potential in Cancer Treatment.
Neoplasms
Design, synthesis and bioactivity evaluation of coumarin-chalcone hybrids as potential anticancer agents.
Neoplasms
Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor.
Neoplasms
Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents.
Neoplasms
Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase.
Neoplasms
Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols.
Neoplasms
DIAPH3 promotes pancreatic cancer progression by activating selenoprotein TrxR1-mediated antioxidant effects.
Neoplasms
Diasteltoxins A-C, Asteltoxin-Based Dimers from a Mutant of the Sponge-Associated Emericella variecolor Fungus.
Neoplasms
Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy.
Neoplasms
Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: Possible involvement of ROS and thioredoxin reductase.
Neoplasms
Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma.
Neoplasms
Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition.
Neoplasms
Discovery of New Monocarbonyl Ligustrazine-Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer.
Neoplasms
Disruption of redox homeostasis in the transforming growth factor-alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.
Neoplasms
Diterpenoids with thioredoxin reductase inhibitory activities from Jatropha multifida.
Neoplasms
Dose-biomarker-response modeling of the anticancer effect of ethaselen in a human non-small cell lung cancer xenograft mouse model.
Neoplasms
Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells.
Neoplasms
Dual targeting of the cancer antioxidant network with 1,4-naphthoquinone fused Gold(i) N-heterocyclic carbene complexes.
Neoplasms
Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: A novel synergistic therapeutic approach.
Neoplasms
EF24 induces ROS-mediated apoptosis via targeting thioredoxin reductase 1 in gastric cancer cells.
Neoplasms
Effects of the antioxidant Pycnogenol on cellular redox systems in U1285 human lung carcinoma cells.
Neoplasms
Efficacy of novel methylenecyclohexenone derivatives as TrxR inhibitors in suppressing the proliferation and metastasis of human cancer cells.
Neoplasms
Enhanced targeting of mitochondrial peroxide defense by the combined use of thiosemicarbazones and inhibitors of thioredoxin reductase.
Neoplasms
Enhancement of auranofin-induced apoptosis in MCF-7 human breast cells by selenocystine, a synergistic inhibitor of thioredoxin reductase.
Neoplasms
Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo.
Neoplasms
Enzyme-mediated depletion of l-cyst(e)ine synergizes with thioredoxin reductase inhibition for suppression of pancreatic tumor growth.
Neoplasms
Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention.
Neoplasms
Ethaselen synergizes with oxaliplatin in tumor growth inhibition by inducing ROS production and inhibiting TrxR1 activity in gastric cancer.
Neoplasms
Ethaselen: a novel organoselenium anticancer agent targeting thioredoxin reductase 1 reverses cisplatin resistance in drug-resistant K562 cells by inducing apoptosis.
Neoplasms
Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent.
Neoplasms
Expression of reactive oxygen species-related proteins according to androgen and HER-2 status in estrogen receptor-negative breast cancer.
Neoplasms
Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer.
Neoplasms
Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer.
Neoplasms
From Catalysis to Cancer: Toward Structure-Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents.
Neoplasms
Further exploration of DVD-445 as a lead thioredoxin reductase (TrxR) inhibitor for cancer therapy: Optimization of potency and evaluation of anticancer potential.
Neoplasms
Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase.
Neoplasms
Gene expression analysis on the dicyclanil-induced hepatocellular tumors in mice.
Neoplasms
Glutathione reductase (GSR) gene deletion and chromosome 8 aneuploidy in primary lung cancers detected by fluorescence in situ hybridization.
Neoplasms
Gold(I) carbene complexes causing thioredoxin 1 and thioredoxin 2 oxidation as potential anticancer agents.
Neoplasms
Gold(I) complex of N,N'-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties-potent tight-binding inhibition of thioredoxin reductase.
Neoplasms
Gold(I) complexes with thiosemicarbazones: cytotoxicity against human tumor cell lines and inhibition of thioredoxin reductase activity.
Neoplasms
High Density of NRF2 Expression in Malignant Cells Is Associated with Increased Risk of CNS Metastasis in Early-Stage NSCLC.
Neoplasms
High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs.
Neoplasms
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin ?-2 Expression, and Induce Antitumor Effects against Human Glioma.
Neoplasms
Hypoxia-Sensitive Metal ?-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis.
Neoplasms
Identification and targeting of selective vulnerability rendered by tamoxifen resistance.
Neoplasms
Identification of phenazine analogue as a novel scaffold for thioredoxin reductase I inhibitors against Hep G2 cancer cell lines.
Neoplasms
Increased levels of cytosolic thioredoxin reductase activity and mRNA in rat liver nodules.
Neoplasms
Induction of Oxidative Stress via Inhibition of Thioredoxin Reductase 1 is an Effective Therapeutic Approach for Hepatocellular Carcinoma.
Neoplasms
Induction of thioredoxin, thioredoxin reductase and glutaredoxin activity in mouse skin by TPA, a calcium ionophore and other tumor promoters.
Neoplasms
Inhibition of Both Thioredoxin Reductase and Glutathione Reductase may Contribute to the Anticancer Mechanism of TH-302.
Neoplasms
Inhibition of glutathione synthesis eliminates the adaptive response of ascitic hepatoma 22 cells to nedaplatin that targets thioredoxin reductase.
Neoplasms
Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity.
Neoplasms
Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy.
Neoplasms
Inhibition of thioredoxin reductase by alantolactone prompts oxidative stress-mediated apoptosis of HeLa cells.
Neoplasms
Inhibition of thioredoxin reductase by auranofin induces apoptosis in adriamycin-resistant human K562 chronic myeloid leukemia cells.
Neoplasms
Inhibition of thioredoxin reductase by mansonone F analogues: Implications for anticancer activity.
Neoplasms
Inhibition of Thioredoxin Reductase by Santamarine Conferring Anticancer Effect in HeLa Cells.
Neoplasms
Inhibition of Thioredoxin Reductase by Targeted Selenopolymeric Nanocarriers Synergizes the Therapeutic Efficacy of Doxorubicin in MCF7 Human Breast Cancer Cells.
Neoplasms
Inhibition of TrxR2 suppressed NSCLC cell proliferation, metabolism and induced cell apoptosis through decreasing antioxidant activity.
Neoplasms
Inhibitory effect of green tea extract and (-)-epigallocatechin-3-gallate on mammalian thioredoxin reductase and HeLa cell viability.
Neoplasms
Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance.
Neoplasms
Interactions of nitroaromatic compounds with the Mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells.
Neoplasms
Investigating the Thioredoxin and Glutathione Systems' Response in Lymphoma Cells after Treatment with [Au(d2pype)2]CL.
Neoplasms
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.
Neoplasms
Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells.
Neoplasms
Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis.
Neoplasms
Lichen acids may be used as a potential drug for cancer therapy; by inhibiting mitochondrial thioredoxin reductase purified from rat lung.
Neoplasms
Lichen Acids May Be Used as A Potential Drug For Cancer Therapy; by Inhibiting Mitochondrial Thioredoxin Reductase Purified From Rat Lung.
Neoplasms
LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer.
Neoplasms
Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation.
Neoplasms
Luteolin and 5-flurouracil act synergistically to induce cellular weapons in experimentally induced Solid Ehrlich Carcinoma: Realistic role of P53; a guardian fights in a cellular battle.
Neoplasms
Maintenance of S-nitrosothiol homeostasis plays an important role in growth suppression of estrogen receptor-positive breast tumors.
Neoplasms
Making Aggregation-Induced Emission Luminogen More Valuable by Gold: Enhancing Anticancer Efficacy by Suppressing Thioredoxin Reductase Activity.
Neoplasms
Mammalian thioredoxin reductase alters cytolytic activity of an antibacterial peptide.
Neoplasms
MDA-7/IL-24 induces Bcl-2 denitrosylation and ubiquitin-degradation involved in cancer cell apoptosis.
Neoplasms
Mechanisms of the regulation of thioredoxin reductase activity in cancer cells by the chemopreventive agent selenium.
Neoplasms
Menin?MLL inhibitors induce ferroptosis and enhance the anti?proliferative activity of auranofin in several types of cancer cells.
Neoplasms
Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase.
Neoplasms
miR-125a-5p Functions as Tumor Suppressor microRNA And Is a Marker of Locoregional Recurrence And Poor prognosis in Head And Neck Cancer.
Neoplasms
miR-125b-5p inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma via targeting TXNRD1.
Neoplasms
Mitochondria-Targeted Approach: Remarkably Enhanced Cellular Bioactivities of TPP2a as Selective Inhibitor and Probe toward TrxR.
Neoplasms
Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols.
Neoplasms
Mitochondrial targeted curcumin exhibits anticancer effects through disruption of mitochondrial redox and modulation of TrxR2 activity.
Neoplasms
Mitochondrial TXNRD3 confers drug resistance via redox-mediated mechanism and is a potential therapeutic target in vivo.
Neoplasms
Molecular bases of thioredoxin and thioredoxin reductase-mediated prooxidant actions of (-)-epigallocatechin-3-gallate.
Neoplasms
Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase.
Neoplasms
Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase.
Neoplasms
Multifunctional AuI -based AIEgens: Manipulating Molecular Structures and Boosting Specific Cancer Cell Imaging and Theranostics.
Neoplasms
Noble metal targeting of thioredoxin reductase - covalent complexes with thioredoxin and thioredoxin-related protein of 14kDa triggered by cisplatin.
Neoplasms
Noncovalent Self-Assembled Smart Gold(III) Porphyrin Nanodrug for Synergistic Chemo-Photothermal Therapy.
Neoplasms
Novel antitumor adamantane-azole gold(I) complexes as potential inhibitors of thioredoxin reductase.
Neoplasms
Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy.
Neoplasms
Novel mechanism of ethaselen in poorly differentiated colorectal RKO cell growth inhibition: Simultaneous regulation of TrxR transcription, expression and enzyme activity.
Neoplasms
Novel thioredoxin reductase inhibitor butaselen inhibits tumorigenesis by down-regulating programmed death-ligand 1 expression.
Neoplasms
Novel TrxR1 Inhibitors Show Potential for Glioma Treatment by Suppressing the Invasion and Sensitizing Glioma Cells to Chemotherapy.
Neoplasms
Onopordopicrin from the new genus Shangwua as a novel thioredoxin reductase inhibitor to induce oxidative stress-mediated tumor cell apoptosis.
Neoplasms
Organotin complexes containing carboxylate ligands with maleimide and naphthalimide derived partial structures: TrxR inhibition, cytotoxicity and activity in resistant cancer cells.
Neoplasms
Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells.
Neoplasms
Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma.
Neoplasms
Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas.
Neoplasms
Oxidation of structural cysteine residues in thioredoxin 1 by aromatic arsenicals enhances cancer cell cytotoxicity caused by the inhibition of thioredoxin reductase 1.
Neoplasms
Oxidation of thioredoxin reductase in HeLa cells stimulated with tumor necrosis factor-alpha.
Neoplasms
Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches.
Neoplasms
p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA.
Neoplasms
Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer.
Neoplasms
Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice.
Neoplasms
Piperlongumine Analogs Promote A549 Cell Apoptosis through Enhancing ROS Generation.
Neoplasms
Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer.
Neoplasms
Piperlongumine potentiates the antitumor efficacy of oxaliplatin through ROS induction in gastric cancer cells.
Neoplasms
Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress.
Neoplasms
Potent Activity of Indolequinones against Human Pancreatic Cancer: Identification of Thioredoxin Reductase as a Potential Target.
Neoplasms
Potent inhibition of gastric cancer cells by a natural compound via inhibiting TrxR1 activity and activating ROS-mediated p38 MAPK pathway.
Neoplasms
Protective effects of selenium nanoparticle-enriched Lactococcus lactis NZ9000 against enterotoxigenic Escherichia coli K88-induced intestinal barrier damage in mice.
Neoplasms
Proteomic analysis identifies protein targets responsible for depsipeptide sensitivity in tumor cells.
Neoplasms
Quantification of alternative mRNA species and identification of thioredoxin reductase 1 isoforms in human tumor cells.
Neoplasms
Recent advances in the development of thioredoxin reductase inhibitors as anticancer agents.
Neoplasms
Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1.
Neoplasms
Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping.
Neoplasms
Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.
Neoplasms
Redox regulation of protein kinase C by selenometabolites and selenoprotein thioredoxin reductase limits cancer prevention by selenium.
Neoplasms
Refeeding with glucose rather than fructose elicits greater hepatic inflammatory gene expression in mice.
Neoplasms
Restraining Cancer Cells by Dual-Metabolic Inhibitions with a Mitochondrion-Targeted Platinum(II) Complex.
Neoplasms
Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer.
Neoplasms
Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress.
Neoplasms
Rollover Cyclometalation vs Nitrogen Coordination in Tetrapyridyl Anticancer Gold(III) Complexes: Effect on Protein Interaction and Toxicity.
Neoplasms
ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.
Neoplasms
ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin.
Neoplasms
Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase.
Neoplasms
Ruthenium(II) salicylate complexes inducing ROS-mediated apoptosis by targeting thioredoxin reductase.
Neoplasms
Sanguinarine as a new chemical entity of thioredoxin reductase inhibitor to elicit oxidative stress and promote tumor cell apoptosis.
Neoplasms
Selective activation of a prodrug by thioredoxin reductase providing a novel strategy to target cancer cells.
Neoplasms
Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation.
Neoplasms
Selenadiazole derivatives as potent thioredoxin reductase inhibitors that enhance the radiosensitivity of cancer cells.
Neoplasms
Selenadiazole derivatives as theranostic agents for simultaneous cancer chemo-/radiotherapy by targeting thioredoxin reductase.
Neoplasms
Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase.
Neoplasms
Sensitivity and resistance in human metastatic melanoma to the new chloroethylnitrosourea anti-tumor drug Fotemustine.
Neoplasms
Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.
Neoplasms
Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells.
Neoplasms
SIGNIFICANCE OF THE MITOCHONDRIAL THIOREDOXIN REDUCTASE IN CANCER CELLS: AN UPDATE ON ROLE, TARGETS AND INHIBITORS.
Neoplasms
SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC.
Neoplasms
Smart mitochondrial-targeted cancer therapy: Subcellular distribution, selective TrxR2 inhibition accompany with declined antioxidant capacity.
Neoplasms
Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents.
Neoplasms
Spectroscopic and electrochemical characterization of gold(I) and gold(III) complexes with glyoxaldehyde bis(thiosemicarbazones): cytotoxicity against human tumor cell lines and inhibition of thioredoxin reductase activity.
Neoplasms
Statins inhibit expression of thioredoxin reductase 1 in rat and human liver and reduce tumour development.
Neoplasms
Sublethal concentrations of diverse gold compounds inhibit mammalian cytosolic thioredoxin reductase (TrxR1).
Neoplasms
Susceptibility of the antioxidant selenoenzymes thioredoxin reductase and glutathione peroxidase to alkylation-mediated inhibition by anticancer acylfulvenes.
Neoplasms
Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells.
Neoplasms
Synergy between sulforaphane and selenium in protection against oxidative damage in colonic CCD841 cells.
Neoplasms
Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors.
Neoplasms
Synthesis and molecular recognition studies on small-molecule inhibitors for thioredoxin reductase.
Neoplasms
Synthesis of 5,5'-dithiobis(2-nitrobenzamides) as alternative substrates for trypanothione reductase and thioredoxin reductase: a microtiter colorimetric assay for inhibitor screening.
Neoplasms
Synthesis of 5-nitro-2-furancarbohydrazides and their cis-diamminedichloroplatinum complexes as bitopic and irreversible human thioredoxin reductase inhibitors.
Neoplasms
Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent.
Neoplasms
Synthesis, SAR and biological evaluation of a novel series of 1-(2-chloroethyl)-1-nitroso-3-(2-(3-oxobenzoelenazol-2(3H)-yl)ethyl) urea: Organoselenium compounds for cancer therapy.
Neoplasms
Targeting selenium metabolism and selenoproteins: novel avenues for drug discovery.
Neoplasms
Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication.
Neoplasms
Targeting thioredoxin reductase by deoxyelephantopin from Elephantopus scaber triggers cancer cell apoptosis.
Neoplasms
Targeting thioredoxin reductase by plumbagin contributes to inducing apoptosis of HL-60 cells.
Neoplasms
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide.
Neoplasms
Targeting Thioredoxin Reductase: Anticancer Agents and Chemopreventive Compounds.
Neoplasms
The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways.
Neoplasms
The Antagonistic Effect of Selenium on Cadmium-Induced Damage and mRNA Levels of Selenoprotein Genes and Inflammatory Factors in Chicken Kidney Tissue.
Neoplasms
The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation.
Neoplasms
The antimetastatic effect and underlying mechanisms of thioredoxin reductase inhibitor ethaselen.
Neoplasms
The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity.
Neoplasms
The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth.
Neoplasms
The effect of sodium selenite on liver growth and thioredoxin reductase expression in regenerative and neoplastic liver cell proliferation.
Neoplasms
The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage.
Neoplasms
The mechanism of apoptosis induced by a novel thioredoxin reductase inhibitor in A549 cells: possible involvement of nuclear factor-kappaB-dependent pathway.
Neoplasms
The novel SOD mimetic GC4419 increases cancer cell killing with sensitization to ionizing radiation while protecting normal cells.
Neoplasms
The role of thioredoxin reductase and glutathione reductase in plumbagin-induced, reactive oxygen species-mediated apoptosis in cancer cell lines.
Neoplasms
The serum activity of thioredoxin reductases 1 (TrxR1) is correlated with the poor prognosis in EGFR wild-type and ALK negative non-small cell lung cancer.
Neoplasms
Thiol antioxidant thioredoxin reductase: A prospective biochemical crossroads between anticancer and antiparasitic treatments of the modern era.
Neoplasms
Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy.
Neoplasms
Thioredoxin and thioredoxin reductase expression in thyroid cancer depends on tumour aggressiveness.
Neoplasms
Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.
Neoplasms
Thioredoxin and thioredoxin reductase: current research with special reference to human disease.
Neoplasms
Thioredoxin is associated with proliferation, p53 expression and negative estrogen and progesterone receptor status in breast carcinoma.
Neoplasms
Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism.
Neoplasms
Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells.
Neoplasms
Thioredoxin reductase 1 is upregulated in atherosclerotic plaques: specific induction of the promoter in human macrophages by oxidized low-density lipoproteins.
Neoplasms
Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis.
Neoplasms
Thioredoxin Reductase Activity Predicts Gold Nanoparticle Radiosensitization Effect.
Neoplasms
Thioredoxin reductase and cancer cell growth inhibition by organogold(III) compounds.
Neoplasms
Thioredoxin reductase and cancer cell growth inhibition by organotellurium antioxidants.
Neoplasms
Thioredoxin reductase and cancer cell growth inhibition by organotellurium compounds that could be selectively incorporated into tumor cells.
Neoplasms
Thioredoxin Reductase as a Novel and Efficient Plasma Biomarker for the Detection of Non-Small Cell Lung Cancer: a Large-scale, Multicenter study.
Neoplasms
Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy.
Neoplasms
Thioredoxin reductase inhibition by antitumor quinols: a quinol pharmacophore effect correlating to antiproliferative activity.
Neoplasms
Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity.
Neoplasms
Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles.
Neoplasms
Thioredoxin reductase regulates angiogenesis by increasing endothelial cell-derived vascular endothelial growth factor.
Neoplasms
Thioredoxin reductase, a redox-active selenoprotein, is secreted by normal and neoplastic cells: presence in human plasma.
Neoplasms
Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells.
Neoplasms
Thioredoxin, thioredoxin reductase and tumour necrosis factor-alpha expression in melanoma cells: correlation to resistance against cytotoxic attack.
Neoplasms
TIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport.
Neoplasms
Tissue and Plasma Thioredoxin Reductase Expressions in Patients with Glioblastoma Multiforme.
Neoplasms
Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2.
Neoplasms
Transcriptomic analysis of the effect of ifosfamide on MDCK cells cultivated in microfluidic biochips.
Neoplasms
Treatment of lung cancer cells with cytotoxic levels of sodium selenite: effects on the thioredoxin system.
Neoplasms
TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin.
Neoplasms
TXNRD1 Is an Unfavorable Prognostic Factor for Patients with Hepatocellular Carcinoma.
Neoplasms
Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma.
Neoplasms
Upregulation of the thioredoxin-dependent redox system during differentiation of 3T3-L1 cells to adipocytes.
Neoplasms
Water-soluble organotellurium compounds inhibit thioredoxin reductase and the growth of human cancer cells.
Neoplasms
Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma.
Neoplasms
Xanthatin Promotes Apoptosis via Inhibiting Thioredoxin Reductase and Eliciting Oxidative Stress.
Neoplasms
[Correlation of plasma thioredoxin reductase activity to growth of H22 hepatocellular carcinoma xenografts in Kunming mice.]
Neoplasms
[Selenoprotein thioredoxin reductase mediated menadione reduction: catalytic properties & inhibition effects].
Nervous System Diseases
Thioredoxin reductase 1 haplotypes modify familial amyotrophic lateral sclerosis onset.
Neuroblastoma
Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols.
Neuroblastoma
Diphenyl diselenide protects against methylmercury-induced inhibition of thioredoxin reductase and glutathione peroxidase in human neuroblastoma cells: a comparison with ebselen.
Neuroblastoma
Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury.
Neuroblastoma
Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy.
Neuroblastoma
Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway.
Neuroblastoma
Thioredoxin alters the matrix metalloproteinase/tissue inhibitors of metalloproteinase balance and stimulates human SK-N-SH neuroblastoma cell invasion.
Neuroblastoma
Toxicological effects of thiomersal and ethylmercury: Inhibition of the thioredoxin system and NADP(+)-dependent dehydrogenases of the pentose phosphate pathway.
Neurocysticercosis
Purification and kinetic analysis of cytosolic and mitochondrial thioredoxin glutathione reductase extracted from Taenia solium cysticerci.
Neuroectodermal Tumors, Primitive
Mutational landscape and potential therapeutic targets for sporadic pancreatic neuroendocrine tumors based on target next-generation sequencing.
Neuroinflammatory Diseases
Altered Expression of Peroxiredoxins in Mouse Model of Progressive Myoclonus Epilepsy upon LPS-Induced Neuroinflammation.
Neuroinflammatory Diseases
Selol, an organic selenium donor, prevents lipopolysaccharide-induced oxidative stress and inflammatory reaction in the rat brain.
Nevi and Melanomas
The role of thioredoxin reductase 1 in melanoma metabolism and metastasis.
Nevus
A Phase II Randomized Placebo-Controlled Trial of Oral N-acetylcysteine for Protection of Melanocytic Nevi against UV-Induced Oxidative Stress In Vivo.
Obesity
GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity.
Obesity
Sexual dimorphism in the effect of maternal obesity on antioxidant defense mechanisms in the human placenta.
Osteoarthritis
Patients with Osteoarthritis and Kashin-Beck Disease Display Distinct CpG Methylation Profiles in the DIO2, GPX3, and TXRND1 Promoter Regions.
Osteoporosis
A microarray based identification of osteoporosis-related genes in primary culture of human osteoblasts.
Osteosarcoma
Auranofin improves overall survival when combined with standard of care in a pilot study involving dogs with osteosarcoma.
Ototoxicity
Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures.
Ovarian Neoplasms
A panel of three oxidative stress-related genes predicts overall survival in ovarian cancer patients received platinum-based chemotherapy.
Ovarian Neoplasms
Antiproliferative Homoleptic and Heteroleptic Phosphino Silver(I) Complexes: Effect of Ligand Combination on Their Biological Mechanism of Action.
Ovarian Neoplasms
Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase.
Ovarian Neoplasms
Induction of apoptosis on ovarian adenocarcinoma cells, A2780 by tricyclohexylphosphanegold (I) mercaptobenzoate derivatives via intrinsic and extrinsic pathways.
Ovarian Neoplasms
Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells.
Ovarian Neoplasms
Novel insights into the synergistic interaction of a thioredoxin reductase inhibitor and TRAIL: the activation of the ASK1-ERK-Sp1 pathway.
Ovarian Neoplasms
Restraining Cancer Cells by Dual-Metabolic Inhibitions with a Mitochondrion-Targeted Platinum(II) Complex.
Pancreatic Neoplasms
A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells.
Pancreatic Neoplasms
Antitumor Indolequinones Induced Apoptosis in Human Pancreatic Cancer Cells via Inhibition of Thioredoxin Reductase and Activation of Redox Signaling.
Pancreatic Neoplasms
Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity.
Pancreatic Neoplasms
Cytotoxic and radiosensitising effects of a novel thioredoxin reductase inhibitor in breast cancer.
Pancreatic Neoplasms
Potent Activity of Indolequinones against Human Pancreatic Cancer: Identification of Thioredoxin Reductase as a Potential Target.
Pancreatic Neoplasms
[Drug resistance and activity changes of thioredoxin reductase in pancreatic cancer cells strain SW1990 induced by gemcitabine]
Paralysis
Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins.
Parasitic Diseases
A review on the druggability of a thiol-based enzymatic antioxidant thioredoxin reductase for treating filariasis and other parasitic infections.
Parasitic Diseases
Purification and kinetic analysis of cytosolic and mitochondrial thioredoxin glutathione reductase extracted from Taenia solium cysticerci.
Parasitic Diseases
The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation.
Parkinson Disease
A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model.
Parkinson Disease
Downregulation of thioredoxin reductase 1 expression in the substantia nigra pars compacta of Parkinson's disease mice.
Parkinson Disease
Overexpression of thioredoxin reductase 1 can reduce DNA damage, mitochondrial autophagy and endoplasmic reticulum stress in Parkinson's disease.
Perinatal Death
Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium.
Pneumocystis Infections
Characterization of thioredoxin reductase genes (trr1) from Pneumocystis carinii and Pneumocystis jiroveci.
Pre-Eclampsia
Correlation of thioredoxin reductase (TrxR) and nitric oxide synthase (NOS) activities with serum trace elements in preeclampsia.
Prostatic Hyperplasia
Stromal response to prostate cancer: nanotechnology-based detection of thioredoxin-interacting protein partners distinguishes prostate cancer associated stroma from that of benign prostatic hyperplasia.
Prostatic Neoplasms
A novel organoselenium compound induces cell cycle arrest and apoptosis in prostate cancer cell lines.
Prostatic Neoplasms
Antitumor activity of gold(III)-dithiocarbamato derivatives on prostate cancer cells and xenografts.
Prostatic Neoplasms
Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells.
Prostatic Neoplasms
Hemolysate thioredoxin reductase and glutathione peroxidase activities correlate with serum selenium in a group of New Zealand men at high prostate cancer risk.
Prostatic Neoplasms
In-vitro and in-vivo investigations into the carbene-gold anticancer drug candidates NHC*-Au-SCSNMe2 and NHC*-Au-S-GLUC against advanced prostate cancer PC3.
Prostatic Neoplasms
Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells.
Prostatic Neoplasms
Oxidative stress measured by thioredoxin reductase level as potential biomarker for prostate cancer.
Prostatic Neoplasms
Polymorphisms in thioredoxin reductase and selenoprotein K genes and selenium status modulate risk of prostate cancer.
Prostatic Neoplasms
Potent In Vitro and In Vivo Anticancer Activity of New Bipyridine and Bipyrimidine Gold (III) Dithiocarbamate Derivatives.
Prostatic Neoplasms
Preparation of Titanocene-Gold Compounds Based on Highly Active Gold(I)-N-Heterocyclic Carbene Anticancer Agents: Preliminary in?vitro Studies in Renal and Prostate Cancer Cell Lines.
Prostatic Neoplasms
Selenium- or Vitamin E-Related Gene Variants, Interaction with Supplementation, and Risk of High-Grade Prostate Cancer in SELECT.
Prostatic Neoplasms
Selenoprotein and antioxidant genes and the risk of high-grade prostate cancer and prostate cancer recurrence.
Prostatic Neoplasms
Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.
Prostatic Neoplasms
Stromal response to prostate cancer: nanotechnology-based detection of thioredoxin-interacting protein partners distinguishes prostate cancer associated stroma from that of benign prostatic hyperplasia.
Prostatic Neoplasms
Thioredoxin Reductase 1 Expression and Castration-recurrent Growth of Prostate Cancer.
Prostatic Neoplasms
Titanocene-Gold Complexes Containing N-Heterocyclic Carbene Ligands Inhibit Growth of Prostate, Renal, and Colon Cancers in Vitro.
Prostatic Neoplasms
Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer.
Protoporphyria, Erythropoietic
Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay.
Psoriasis
Anthralin inhibits elevated levels of thioredoxin reductase in psoriasis. A new mode of action for this drug.
Psoriasis
Synthesis of 5,5'-dithiobis(2-nitrobenzamides) as alternative substrates for trypanothione reductase and thioredoxin reductase: a microtiter colorimetric assay for inhibitor screening.
Psoriasis
The Relationship between Tissue Thioredoxin Reductase Activity and the Psoriasis Area and Severity Index.
Pulmonary Disease, Chronic Obstructive
Associations of the NRF2/KEAP1 pathway and antioxidant defense gene polymorphisms with chronic obstructive pulmonary disease.
Pulmonary Fibrosis
Inhibitory effects of thalidomide on bleomycin-induced pulmonary fibrosis in rats via regulation of thioredoxin reductase and inflammations.
Radiation Fibrosis Syndrome
SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling.
Renal Insufficiency, Chronic
Differential expression of MAP3K7 and TROPONIN C proteins and related perturbations in renal amyloidosis.
Reperfusion Injury
Effects of intermittent hypoxia on oxidative stress-induced myocardial damage in mice.
Reperfusion Injury
Myocardial ischemia-reperfusion injury, antioxidant enzyme systems, and selenium: a review.
Respiratory Distress Syndrome
The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms.
Respiratory Distress Syndrome
The Thioredoxin Reductase-1 Inhibitor Aurothioglucose Attenuates Lung Injury and Improves Survival in a Murine Model of Acute Respiratory Distress Syndrome.
Respiratory Insufficiency
Why 21? The significance of selenoproteins for human health revealed by inborn errors of metabolism.
Rhabdomyosarcoma, Alveolar
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Seizures
Up-regulation of antioxidative proteins TRX1, TXNL1 and TXNRD1 in the cortex of PTZ kindling seizure model mice.
Sepsis
Oxidant and antioxidant status in neonatal proven and clinical sepsis according to selenium status.
Small Cell Lung Carcinoma
Mammalian thioredoxin reductase alters cytolytic activity of an antibacterial peptide.
Squamous Cell Carcinoma of Head and Neck
Is selenium a potential treatment for cancer metastasis?
Squamous Cell Carcinoma of Head and Neck
Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
PARP-1 inhibitors sensitize HNSCC cells to APR-246 by inactivation of thioredoxin reductase 1 (TrxR1) and promotion of ROS accumulation.
Squamous Cell Carcinoma of Head and Neck
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Squamous Cell Carcinoma of Head and Neck
The chemopreventive and clinically used agent curcumin sensitizes HPV (-) but not HPV (+) HNSCC to ionizing radiation, in vitro and in a mouse orthotopic model.
Squamous Cell Carcinoma of Head and Neck
The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo.
Squamous Cell Carcinoma of Head and Neck
Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.
Starvation
Immunohistochemical localization of thioredoxin and thioredoxin reductase in mouse exocrine and endocrine pancreas.
Starvation
Upregulation of stress response genes and ABC transporters in anaerobic stationary-phase Mycobacterium smegmatis.
Stomach Neoplasms
A thioredoxin reductase inhibitor ethaselen induces growth inhibition and apoptosis in gastric cancer.
Stomach Neoplasms
Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a.
Stomach Neoplasms
Author Correction: Plasma activity of Thioredoxin Reductase as a Novel Biomarker in Gastric Cancer.
Stomach Neoplasms
Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells.
Stomach Neoplasms
Curcuminoid WZ35 synergize with cisplatin by inducing ROS production and inhibiting TrxR1 activity in gastric cancer cells.
Stomach Neoplasms
EF24 induces ROS-mediated apoptosis via targeting thioredoxin reductase 1 in gastric cancer cells.
Stomach Neoplasms
Ethaselen synergizes with oxaliplatin in tumor growth inhibition by inducing ROS production and inhibiting TrxR1 activity in gastric cancer.
Stomach Neoplasms
Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer.
Stomach Neoplasms
Piperlongumine potentiates the antitumor efficacy of oxaliplatin through ROS induction in gastric cancer cells.
Stomach Neoplasms
Plasma activity of Thioredoxin Reductase as a Novel Biomarker in Gastric Cancer.
Stomach Neoplasms
Potent inhibition of gastric cancer cells by a natural compound via inhibiting TrxR1 activity and activating ROS-mediated p38 MAPK pathway.
Stomach Neoplasms
Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation.
Stomach Neoplasms
[Association of genetic polymorphisms in selenoprotein GPX1 and TXNRD2 with genetic susceptibility of gastric cancer]
Stomach Neoplasms
[Expression of thioredoxin reductase 1 (TrxR1) in gastric cancer and its effect on the growth of gastric cancer cells].
Stroke
Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe.
thioredoxin-disulfide reductase deficiency
Enhancement of the efficacy of mitomycin C-mediated apoptosis in human colon cancer cells with RNAi-based thioredoxin reductase 1 deficiency.
thioredoxin-disulfide reductase deficiency
Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1.
thioredoxin-disulfide reductase deficiency
Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation.
thioredoxin-disulfide reductase deficiency
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.
thioredoxin-disulfide reductase deficiency
Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells.
thioredoxin-disulfide reductase deficiency
Roles of thioredoxin reductase during the aerobic life of Lactococcus lactis.
thioredoxin-disulfide reductase deficiency
Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism.
thioredoxin-disulfide reductase deficiency
Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells.
thioredoxin-disulfide reductase deficiency
Thioredoxin reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD).
thioredoxin-disulfide reductase deficiency
Thioredoxin reductase deficiency potentiates oxidative stress, mitochondrial dysfunction and cell death in dopaminergic cells.
thioredoxin-disulfide reductase deficiency
TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species.
Thyroid Neoplasms
A possible role for selenoprotein glutathione peroxidase (GPx1) and thioredoxin reductases (TrxR1) in thyroid cancer: our experience in thyroid surgery.
Thyroid Neoplasms
Thioredoxin and thioredoxin reductase expression in thyroid cancer depends on tumour aggressiveness.
Tongue Neoplasms
The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo.
Triple Negative Breast Neoplasms
Alantolactone promotes ER stress-mediated apoptosis by inhibition of TrxR1 in triple-negative breast cancer cell lines and in a mouse model.
Triple Negative Breast Neoplasms
Cytotoxic and radiosensitising effects of a novel thioredoxin reductase inhibitor in breast cancer.
Triple Negative Breast Neoplasms
Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancer.
Tuberculosis
Cloning, expression and significance of MPT53 for identification of secreted proteins of Mycobacterium tuberculosis.
Tuberculosis
Conformational flexibility of Mycobacterium tuberculosis thioredoxin reductase: crystal structure and normal-mode analysis.
Tuberculosis
Docking into Mycobacterium tuberculosis Thioredoxin Reductase Protein Yields Pyrazolone Lead Molecules for Methicillin-Resistant Staphylococcus aureus.
Tuberculosis
Ebselen and analogs as inhibitors of Bacillus anthracis thioredoxin reductase and bactericidal antibacterials targeting Bacillus species, Staphylococcus aureus and Mycobacterium tuberculosis.
Tuberculosis
Expression, purification, crystallization and preliminary X-ray crystallographic studies of Mycobacterium tuberculosis thioredoxin reductase.
Tuberculosis
Glutathione disulfide and S-nitrosoglutathione detoxification by Mycobacterium tuberculosis thioredoxin system.
Tuberculosis
Histone Methyltransferase SET8 Epigenetically Reprograms Host Immune Responses to Assist Mycobacterial Survival.
Tuberculosis
Identification of M. tuberculosis thioredoxin reductase inhibitors based on high-throughput docking using constraints.
Tuberculosis
Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis.
Tuberculosis
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.
Tuberculosis
NrdH-redoxin of Mycobacterium tuberculosis and Corynebacterium glutamicum Dimerizes at High Protein Concentration and Exclusively Receives Electrons from Thioredoxin Reductase.
Tuberculosis
Reduction of peroxides and dinitrobenzenes by Mycobacterium tuberculosis thioredoxin and thioredoxin reductase.
Tuberculosis
Solution structures of Mycobacterium tuberculosis thioredoxin C and models of intact thioredoxin system suggest new approaches to inhibitor and drug design.
Tuberculosis
Structure-based identification of natural compound inhibitor against M. tuberculosis thioredoxin reductase: insight from molecular docking and dynamics simulation.
Tuberculosis
The crystal structure of Mycobacterium tuberculosis NrdH at 0.87 Å suggests a possible mode of its activity.
Tuberculosis
Upregulation of stress response genes and ABC transporters in anaerobic stationary-phase Mycobacterium smegmatis.
Tuberous Sclerosis
Activated p53 in the anti-apoptotic milieu of tuberous sclerosis gene mutation induced diseases leads to cell death if thioredoxin reductase is inhibited.
Urinary Bladder Neoplasms
p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells.
Uterine Cervical Neoplasms
B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy.
Uterine Cervical Neoplasms
EM23, a natural sesquiterpene lactone, targets thioredoxin reductase to activate JNK and cell death pathways in human cervical cancer cells.
Uterine Cervical Neoplasms
Novel triazolium based 11(th) group NHCs: synthesis, characterization and cellular response mechanisms.
Uterine Cervical Neoplasms
Potent and selective cytotoxic and anti-inflammatory gold(III) compounds containing cyclometallated phosphine sulfide ligands.
Varicocele
Is thioredoxin reductase involved in the defense against DNA fragmentation in varicocele?
Vascular Diseases
Induction of Thioredoxin Reductase 1 by Korean Red Ginseng Water Extract Regulates Cytoprotective Effects on Human Endothelial Cells.
Vitiligo
In vivo and in vitro evidence for epidermal HO-mediated oxidative stress in piebaldism.
Xeroderma Pigmentosum
Defects in antioxidant defense and calcium transport in the epidermis of xeroderma pigmentosum patients.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.47
5,5'-dithiobis(2-nitrobenzoic acid)
full-length mouse enzyme with C-terminal sequence GCUG
2.72
5,5'-dithiobis(2-nitrobenzoic acid)
truncated mutant enzyme (missing residues CUG from the C-terminus) so that Gly521 is the C-terminal amino acid
0.032
thioredoxin disulfide
full-length mouse enzyme with C-terminal sequence SCCS
0.0676
thioredoxin disulfide
full-length mouse enzyme with C-terminal sequence GCUG
0.123
thioredoxin disulfide
full-length mouse enzyme with C-terminal sequence GCCG
additional information
additional information
KM-values of semisynthetic truncated mTR3 enzymes
-
additional information
additional information
-
KM-values of semisynthetic truncated mTR3 enzymes
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
15.6
5,5'-dithiobis(2-nitrobenzoic acid)
truncated mutant enzyme (missing residues CUG from the C-terminus) so that Gly521 is the C-terminal amino acid
20.83
5,5'-dithiobis(2-nitrobenzoic acid)
full-length mouse enzyme with C-terminal sequence GCUG
0.083
thioredoxin disulfide
full-length mouse enzyme with C-terminal sequence SCCS
0.13
thioredoxin disulfide
full-length mouse enzyme with C-terminal sequence GCCG
37
thioredoxin disulfide
full-length mouse enzyme with C-terminal sequence GCUG
additional information
additional information
turnover number of semisynthetic truncated mTR3 enzymes
-
additional information
additional information
-
turnover number of semisynthetic truncated mTR3 enzymes
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.5 - 9
pH 6.5: about 40% of maximal activity, pH 9.0: about 50% of maximal activity, wild-type enzyme
6.5 - 9.5
pH 6.5: 45% of maximal activity, pH 9.5: about 50% of maximal activity, mutant enzyme Sec489C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
the mutant in the which Sec and Cys residues are switched (TR-GUCG), shows activity similar to that of the Sec489Cys mutant (TR-GCCG). Replacement of the Cys-Sec dyad with a Sec-Sec dyad (TR-GUUG) results in a mutant enzyme with very low catalytic activity. Even if the kcat values are normalized for selenium content, the TR-GUCG and TR-GUUG mutants have catalytic activity 90fold and 185fold lower, respectively, than that of the wild-type enzyme. The mutants in which alanine residues are inserted to increase the ring size (TR-GCAUG and TR-GCAAUG) show only a modest decrease in catalytic activity, 6fold and 4fold, respectively
additional information
-
the mutant in the which Sec and Cys residues are switched (TR-GUCG), shows activity similar to that of the Sec489Cys mutant (TR-GCCG). Replacement of the Cys-Sec dyad with a Sec-Sec dyad (TR-GUUG) results in a mutant enzyme with very low catalytic activity. Even if the kcat values are normalized for selenium content, the TR-GUCG and TR-GUUG mutants have catalytic activity 90fold and 185fold lower, respectively, than that of the wild-type enzyme. The mutants in which alanine residues are inserted to increase the ring size (TR-GCAUG and TR-GCAAUG) show only a modest decrease in catalytic activity, 6fold and 4fold, respectively
additional information
the truncated mutant enzyme (missing residues CUG from the C-terminus) so that Gly521 is the C-terminal amino acid shows no activity with thioredoxin disulfide + NADPH
additional information
-
the truncated mutant enzyme (missing residues CUG from the C-terminus) so that Gly521 is the C-terminal amino acid shows no activity with thioredoxin disulfide + NADPH
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
the full-length Sec489Cys mutant as well as the truncated mTR3 missing the C-terminal CUG tripeptide sequence is expressed as a TR-intein-chitin binding domain fusion protein in Escherichia coli
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Eckenroth, B.E.; Rould, M.A.; Hondal, R.J.; Everse, S.J.
Structural and biochemical studies reveal differences in the catalytic mechanisms of mammalian and Drosophila melanogaster thioredoxin reductases
Biochemistry
46
4694-4705
2007
Drosophila melanogaster (P91938), Drosophila melanogaster, Mus musculus (Q8BTW3), Mus musculus
brenda
Eckenroth, B.E.; Lacey, B.M.; Lothrop, A.P.; Harris, K.M.; Hondal, R.J.
Investigation of the C-terminal redox center of high-Mr thioredoxin reductase by protein engineering and semisynthesis
Biochemistry
46
9472-9483
2007
Caenorhabditis elegans, Drosophila melanogaster, Mus musculus (Q8BTW3), Mus musculus
brenda
EXTERNAL LINKS (specific for EC-Number 1.8.1.9)
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
About BRENDA
Social media
Help
Survey
Download
Contribution
Legal
Curated at
Member of
