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EC Tree
IUBMB Comments A dimeric flavoprotein (FAD); activity is dependent on a redox-active disulfide in each of the active centres.
The taxonomic range for the selected organisms is: Oryza sativa The enzyme appears in selected viruses and cellular organisms
Synonyms
glutathione reductase, gsh reductase, gssg reductase, glutathione disulfide reductase, ptgr2, gsr-1, glutathione-disulfide reductase, glutathione s-reductase, thioredoxin/glutathione reductase, nadph-glutathione reductase,
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glutathione reductase (NADPH)
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glutathione reductase 3
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glutathione S-reductase
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GR1
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chloroplastic isoform
NADPH-glutathione reductase
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NADPH-GSSG reductase
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NADPH:oxidized-glutathione oxidoreductase
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reductase, glutathione
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glutathione reductase
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glutathione reductase
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Gr3
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chloroplastic isoform
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glutathione:NADP+ oxidoreductase
A dimeric flavoprotein (FAD); activity is dependent on a redox-active disulfide in each of the active centres.
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glutathione disulfide + NADPH
glutathione + NADP+
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glutathione disulfide + NADPH + H+
glutathione + NADP+
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glutathione disulfide + NADPH + H+
glutathione + NADP+
GSSG + NADPH
glutathione + NADP+
glutathione disulfide + NADPH + H+
glutathione + NADP+
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glutathione disulfide + NADPH + H+
glutathione + NADP+
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GSSG + NADPH
glutathione + NADP+
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GSSG + NADPH
glutathione + NADP+
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r
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glutathione disulfide + NADPH
glutathione + NADP+
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glutathione disulfide + NADPH + H+
glutathione + NADP+
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glutathione disulfide + NADPH + H+
glutathione + NADP+
glutathione disulfide + NADPH + H+
glutathione + NADP+
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glutathione disulfide + NADPH + H+
glutathione + NADP+
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NADPH
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FAD
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FAD
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2 mol of FAD per mol of enzyme
FAD
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the enzyme contains one FAD per monomer
NADPH
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NADPH
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absolute specificity for NADPH
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H2O2
increases enzyme activity
NaCl
increases enzyme activity involving plasma membrane NADPH-oxidase
additional information
NaCl and H2O2 induce enzyme expression in roots
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additional information
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NaCl and H2O2 induce enzyme expression in roots
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6.3 - 9.6
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at pH 6.3-9.6 about 50% of activity maximum
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SwissProt
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cv. Taichung Native 1
SwissProt
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seedling
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glutathione reductase increases in response to Fe-deficiency
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glutathione reductase increases in response to Fe-deficiency
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main localization
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isoforms GR1 and GR3
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isoform GR2
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physiological function
rice enzyme expression in yeast increases the ability of the cells to adapt and recover from H2O2-induced oxidative stress and various stimuli including heat shock and exposure to menadione, heavy metals (iron, zinc, copper, and cadmium), SDS, ethanol, and sulfuric acid
physiological function
the enzyme is involved in salt stress response and biotic stress tolerance
physiological function
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the enzyme plays an essential central role in cell defense against reactive oxygen metabolites. The enzyme plays an important role in plant protection against various forms of stress
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55000
2 * 55000, SDS-PAGE
106000
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calculation from sedimentation and diffusion coefficients
52000
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2 * 52000, SDS-PAGE
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homodimer
2 * 55000, SDS-PAGE
dimer
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2 * 52000, SDS-PAGE
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nickel affinity column chromatography
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expressed in Saccharomyces cerevisiae BY4741 cells
expressed in Escherichia coli BL21(DE3) cells
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expression of isoform GR3 is induced by salt stress (35fold in shoots at 200 mM NaCl, 6fold in roots by 100 mM NaCl). In addition, the transcript level of isoform GR3 is greatly increased with salicylic acid treatment (0.1-0.2 mM)
the expression of isoforms GR2 and GR3 but not GR1 is increased in rice roots treated with NaCl, Na+ but not Cl- or osmotic stress is involved in NaCl-induced expression of glutathione reductase in roots of rice seedlings, after 8 h treatment with NaCl (150, 200, and 300 mM), isoform GR3 expression is specifically increased, the expression of isofomr GR2 is also increased by 150 and 200 mM NaCl but not 300 mM NaCl, no significant increase due to NaCl (150, 200, and 300 mM) can be detected in the expression of isoform GR1
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the transcript level of isoform GR3 is not significantly affected by methyl jasmonate, dehydration or heat shock stress
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Ida, S.; Morita, Y.
Studies on respiratory enzymes in rice kernel. Part VII. Purification of an acidic flavoprotein, glutathione reductase, from rice embryos
Agric. Biol. Chem.
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1542-1549
1971
Oryza sativa
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Ida, S.; Morita, Y.
Studies on respiratory enzymes in rice kernel. Part VIII. Enzymatic properties and physical and chemical characterization of glutathione reductase from rice embryos
Agric. Biol. Chem.
35
1550-1557
1971
Oryza sativa
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Tsai, Y.C.; Hong, C.Y.; Liu, L.F.; Kao, C.H.
Expression of ascorbate peroxidase and glutathione reductase in roots of rice seedlings in response to NaCl and H2O2
J. Plant Physiol.
162
291-299
2005
Oryza sativa (P48642), Oryza sativa
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Bashir, K.; Nagasaka, S.; Itai, R.N.; Kobayashi, T.; Takahashi, M.; Nakanishi, H.; Mori, S.; Nishizawa, N.K.
Expression and enzyme activity of glutathione reductase is upregulated by Fe-deficiency in graminaceous plants
Plant Mol. Biol.
65
277-284
2007
Oryza sativa, Triticum aestivum, Zea mays, Hordeum vulgare (A8CCK2), Hordeum vulgare (A8CCK8), Hordeum vulgare
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Hong, C.Y.; Chao, Y.Y.; Yang, M.Y.; Cho, S.C.; Huei Kao, C.
Na+ but not Cl- or osmotic stress is involved in NaCl-induced expression of glutathione reductase in roots of rice seedlings
J. Plant Physiol.
166
1598-1606
2009
Oryza sativa
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Kim, I.S.; Kim, Y.S.; Yoon, H.S.
Glutathione reductase from Oryza sativa increases acquired tolerance to abiotic stresses in a genetically modified Saccharomyces cerevisiae strain
J. Microbiol. Biotechnol.
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1557-1567
2012
Oryza sativa (P48642), Oryza sativa
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Wu, T.M.; Lin, W.R.; Kao, Y.T.; Hsu, Y.T.; Yeh, C.H.; Hong, C.Y.; Kao, C.H.
Identification and characterization of a novel chloroplast/mitochondria co-localized glutathione reductase 3 involved in salt stress response in rice
Plant Mol. Biol.
83
379-390
2013
Oryza sativa (Q7XEM9), Oryza sativa
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Gill, S.S.; Anjum, N.A.; Hasanuzzaman, M.; Gill, R.; Trivedi, D.K.; Ahmad, I.; Pereira, E.; Tuteja, N.
Glutathione and glutathione reductase: a boon in disguise for plant abiotic stress defense operations
Plant Physiol. Biochem.
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204-212
2013
Arachis hypogaea, Beta vulgaris, Cajanus cajan, Citrullus lanatus, Cucumis sativus, Cucumis melo, Glycine max, Nicotiana tabacum, no activity in Drosophila melanogaster, Oryza sativa, Vigna radiata var. radiata, Pisum sativum, Spinacia oleracea, Triticum aestivum, Zea mays, Acorus calamus, Citrus trifoliata, no activity in Trypanosoma sp.
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